Detailed information for compound 100277

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 363.16 | Formula: C16H11BrO5
  • H donors: 2 H acceptors: 4 LogP: 3.45 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrC1=C[C@H]([C@@H](C1=O)O)OC(=O)c1c(O)ccc2c1cccc2
  • InChi: 1S/C16H11BrO5/c17-10-7-12(15(20)14(10)19)22-16(21)13-9-4-2-1-3-8(9)5-6-11(13)18/h1-7,12,15,18,20H/t12-,15+/m1/s1
  • InChiKey: OGXYWSCTPIKDKD-DOMZBBRYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0069 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.1652 0.4086
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0147 0.1624
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0037 0.0045
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0022 0.0221
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0168 0.1022
Echinococcus granulosus smad 0.0034 0.0048 0.0059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0147 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Loa Loa (eye worm) hypothetical protein 0.0495 0.2716 0.6719
Loa Loa (eye worm) hypothetical protein 0.0724 0.404 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.077 0.19
Loa Loa (eye worm) inositol-1 0.0115 0.052 0.1281
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0051 0.0147 0.1626
Mycobacterium tuberculosis Probable dehydrogenase 0.0334 0.1783 0.3228
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0066 0.0066
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0962 0.5417 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0283 0.0342
Mycobacterium tuberculosis Conserved protein 0.0113 0.0505 0.0846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0279 0.051
Plasmodium vivax SET domain protein, putative 0.0032 0.0037 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0232 0.028
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0019 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0978 0.1183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0118 0.0212
Trichomonas vaginalis mercuric reductase, putative 0.0051 0.0147 0.0266
Plasmodium falciparum glutathione reductase 0.0051 0.0147 0.184
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0168 0.1022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0641 0.1178
Schistosoma mansoni fkbp-rapamycin associated protein 0.0026 0.0003 0.0003
Trichomonas vaginalis glutathione reductase, putative 0.0051 0.0147 0.0266
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0022 0.0122
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0962 0.5417 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.008 0.0314 0.038
Schistosoma mansoni ferritin 0.0034 0.005 0.0061
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0081 0.0081
Trichomonas vaginalis inositol monophosphatase, putative 0.0115 0.052 0.0955
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0689 0.3954
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0724 0.404 1
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0137 0.0645 0.1108
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0041 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0113 0.0505 0.1243
Echinococcus multilocularis Smad4 0.0034 0.0048 0.0048
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0505 0.0505
Onchocerca volvulus 0.0113 0.0505 0.3932
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.008 0.0314 0.0314
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0081 0.0194
Mycobacterium tuberculosis Probable aminotransferase 0.0962 0.5417 1
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0505 0.0846
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0115 0.052 0.7902
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0505 0.0846
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0026 0.0003 0.0003
Mycobacterium ulcerans acetylornithine aminotransferase 0.0137 0.0645 0.1108
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0051 0.0147 0.0147
Schistosoma mansoni apoferritin-2 0.0034 0.005 0.0061
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0022 0.0122
Brugia malayi Bromodomain containing protein 0.0082 0.0327 0.0804
Schistosoma mansoni smad 0.0034 0.0048 0.0059
Onchocerca volvulus 0.0158 0.077 0.6163
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0046 0.0118 0.0142
Schistosoma mansoni survival motor neuron protein 0.0047 0.0125 0.0152
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0371 0.1998 0.3629
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.1618 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.008 0.0314 0.1927
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0048 0.0059
Loa Loa (eye worm) transcription factor SMAD2 0.0494 0.2709 0.6704
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0978 0.0978
Schistosoma mansoni inositol monophosphatase 0.0115 0.052 0.0629
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0051 0.0147 0.0893
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0051 0.0147 0.0428
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1185 0.1433
Brugia malayi MH1 domain containing protein 0.0034 0.0048 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0147 0.0893
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0229 0.1178 0.1425
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0505 0.0927
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0689 0.4247
Brugia malayi MH2 domain containing protein 0.0034 0.0048 0.0113
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0618 0.3429 0.4147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0118 0.0212
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0049
Brugia malayi MH2 domain containing protein 0.0034 0.0048 0.0113
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0962 0.5417 1
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0137 0.0645 0.1108
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0046 0.0118 0.0118
Echinococcus granulosus snurportin 1 0.0311 0.1652 0.1998
Echinococcus multilocularis GPCR, family 2 0.0229 0.1178 0.1178
Brugia malayi hypothetical protein 0.0074 0.0283 0.0694
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0618 0.3429 0.3429
Trichomonas vaginalis esterase, putative 0.0113 0.0505 0.0927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0978 0.1183
Schistosoma mansoni hypothetical protein 0.0874 0.4909 0.5937
Loa Loa (eye worm) hypothetical protein 0.0229 0.1178 0.2912
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0066 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0439 0.0806
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0147 0.0893
Onchocerca volvulus 0.0113 0.0505 0.3932
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0229 0.1178 0.1178
Loa Loa (eye worm) Smad1 0.0034 0.0048 0.0113
Leishmania major hypothetical protein, conserved 0.0054 0.0168 0.0565
Entamoeba histolytica hypothetical protein 0.0074 0.0283 0.4393
Toxoplasma gondii histone lysine methyltransferase SET1 0.0179 0.089 1
Onchocerca volvulus 0.0113 0.0505 0.3932
Brugia malayi MH1 domain containing protein 0.0034 0.0048 0.0113
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0432 0.0522
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0046 0.0118 0.0239
Loa Loa (eye worm) hypothetical protein 0.0054 0.0168 0.0409
Echinococcus granulosus ferritin 0.0034 0.005 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0439 0.0806
Brugia malayi Latrophilin receptor protein 2 0.0229 0.1178 0.2912
Trichomonas vaginalis ferritin, putative 0.0034 0.005 0.0088
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0505 0.0846
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.008 0.0314 0.0491
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0051 0.0147 0.184
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0136 0.0641 0.3949
Onchocerca volvulus 0.0093 0.039 0.2968
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1061 0.2621
Schistosoma mansoni hypothetical protein 0.0495 0.2716 0.3284
Toxoplasma gondii exonuclease III APE 0.008 0.0314 0.351
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0371 0.1998 0.3629
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0147 0.0893
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0505 0.0846
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0719 0.4011 0.738
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0081 0.1228
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0505 0.0846
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0081 0.0081
Echinococcus granulosus expressed protein 0.0034 0.005 0.0061
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0048 0.0113
Loa Loa (eye worm) thioredoxin reductase 0.0146 0.07 0.1726
Brugia malayi Ets-domain containing protein 0.0073 0.0274 0.0673
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0505 0.0846
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0147 0.0893
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.0118 0.0712
Echinococcus granulosus dnaJ subfamily B 0.0874 0.4909 0.5937
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0505 0.1243
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0232 0.028
Schistosoma mansoni smad1 5 8 and 0.0034 0.0048 0.0059
Toxoplasma gondii thioredoxin reductase 0.0146 0.07 0.7857
Schistosoma mansoni DNA polymerase eta 0.0039 0.0081 0.0098
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0147 0.0893
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0168 0.2149
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0137 0.0645 1
Trypanosoma brucei unspecified product 0.0027 0.0011 0.0049
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0048 0.0059
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0334 0.1783 0.3228
Echinococcus multilocularis ferritin 0.0034 0.005 0.005
Schistosoma mansoni smad1 5 8 and 0.0034 0.0048 0.0059
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0147 0.0428
Treponema pallidum NADH oxidase 0.0051 0.0147 0.3663
Mycobacterium tuberculosis Conserved protein 0.0113 0.0505 0.0846
Toxoplasma gondii ABC1 family protein 0.0113 0.0505 0.5658
Schistosoma mansoni ferritin light chain 0.0034 0.005 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0081 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0279 0.051
Plasmodium vivax glutathione reductase, putative 0.0146 0.07 1
Loa Loa (eye worm) beta-lactamase 0.0113 0.0505 0.1243
Schistosoma mansoni apoferritin-2 0.0034 0.005 0.0061
Loa Loa (eye worm) hypothetical protein 0.0113 0.0505 0.1243
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0505 0.061
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0232 0.0568
Mycobacterium tuberculosis Probable reductase 0.0334 0.1783 0.3228
Loa Loa (eye worm) hypothetical protein 0.0039 0.008 0.0193
Loa Loa (eye worm) hypothetical protein 0.0113 0.0505 0.1243
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0103 0.045 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.002 0.0031
Toxoplasma gondii hypothetical protein 0.0049 0.0138 0.1531
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0147 0.1624
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.008 0.0314 0.4161
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0081 0.0145
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0147 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Loa Loa (eye worm) fli-1 protein 0.0221 0.113 0.2793
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0051 0.0147 0.184
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.052 0.0955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0382 0.07
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0108 0.048 0.2598
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1226 0.2259
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0041 0.009 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0278 0.0509
Mycobacterium ulcerans hypothetical protein 0.0113 0.0505 0.0846
Echinococcus granulosus dna polymerase kappa 0.0039 0.0081 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Echinococcus granulosus microtubule associated protein 2 0.1455 0.8269 1
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0041 0.009 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0065 0.0115
Brugia malayi exodeoxyribonuclease III family protein 0.008 0.0314 0.0771
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.008 0.0314 0.4435
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0041 0.009 0.0217
Loa Loa (eye worm) hypothetical protein 0.0028 0.0014 0.0029
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0136 0.0641 0.3949
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0035 0.008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0051 0.0147 0.0178
Brugia malayi TAR-binding protein 0.0065 0.0232 0.0568
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0137 0.0645 0.159
Schistosoma mansoni hypothetical protein 0.0074 0.0283 0.0342
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0048 0.0048
Brugia malayi Pre-SET motif family protein 0.0032 0.0037 0.0085
Brugia malayi RNA, U transporter 1 0.0083 0.0333 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0278 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.048 0.0881
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0505 0.0927
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.009 0.0162
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0978 0.0978
Mycobacterium ulcerans lipase LipD 0.0113 0.0505 0.0846
Echinococcus multilocularis cpg binding protein 0.01 0.0432 0.0432
Mycobacterium ulcerans beta-lactamase 0.0113 0.0505 0.0846
Brugia malayi Importin beta-1 subunit 0.0029 0.0022 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.048 0.0881
Brugia malayi beta-lactamase 0.0113 0.0505 0.1243
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0125 0.0304
Giardia lamblia GTOR 0.0136 0.0641 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0046 0.0118 0.0142
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0168 0.2149
Plasmodium falciparum ornithine aminotransferase 0.0137 0.0645 0.9192
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0137 0.0645 0.1108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0147 0.0893
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0051 0.0147 0.184
Loa Loa (eye worm) MH2 domain-containing protein 0.0494 0.2709 0.6704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0279 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0324 0.0594
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0227
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.052 0.3202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0138 0.0167
Onchocerca volvulus 0.0047 0.0125 0.0744
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0229 0.1178 0.1178
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0137 0.0645 0.724
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0051 0.0147 0.018
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0505 0.3106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0118 0.0212
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0147 0.0428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0037 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0505 0.0927
Schistosoma mansoni inositol monophosphatase 0.0115 0.052 0.0629
Echinococcus granulosus tar DNA binding protein 0.0065 0.0232 0.028
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0137 0.0645 0.1108
Brugia malayi hypothetical protein 0.0054 0.0168 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0324 0.0594
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0334 0.1783 0.3228
Loa Loa (eye worm) hypothetical protein 0.0062 0.0213 0.0522
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0724 0.404 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.0978 0.2416
Echinococcus multilocularis snurportin 1 0.0311 0.1652 0.1652
Echinococcus granulosus cpg binding protein 0.01 0.0432 0.0522
Brugia malayi hypothetical protein 0.023 0.1185 0.2929
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0102 0.0614
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0237 0.0237
Loa Loa (eye worm) latrophilin receptor protein 2 0.0229 0.1178 0.2912
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0147 0.0893
Schistosoma mansoni importin beta-1 0.0029 0.0022 0.0027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.008 0.0314 0.1515
Schistosoma mansoni ferritin 0.0034 0.005 0.0061
Echinococcus granulosus Aminotransferase class III 0.0137 0.0645 0.078
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0081 0.0057
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0168 0.1022
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0136 0.0641 1
Schistosoma mansoni bromodomain containing protein 0.007 0.0258 0.0312
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0081 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0324 0.0594
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0081 0.0145
Echinococcus granulosus GPCR family 2 0.0229 0.1178 0.1425
Schistosoma mansoni cpg binding protein 0.01 0.0432 0.0522
Mycobacterium ulcerans hypothetical protein 0.0161 0.0783 0.1366
Echinococcus granulosus inositol monophosphatase 1 0.0115 0.052 0.0629
Brugia malayi PHD-finger family protein 0.0031 0.0031 0.0071
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0334 0.1783 0.3228
Loa Loa (eye worm) hypothetical protein 0.023 0.1185 0.2929
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0505 0.3106
Plasmodium falciparum thioredoxin reductase 0.0146 0.07 1
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0505 0.0927
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Echinococcus granulosus dna polymerase eta 0.0039 0.0081 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0279 0.051
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0051 0.0147 0.0428
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.039 0.0959
Echinococcus multilocularis smad 0.0034 0.0048 0.0048
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.009 0.0162
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0018 0.0018
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0051 0.0147 0.184
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0232 0.0568
Schistosoma mansoni smad1 5 8 and 0.0034 0.0048 0.0059
Onchocerca volvulus 0.01 0.0432 0.3318
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0057 0.0181 0.1102
Mycobacterium tuberculosis Probable oxidoreductase 0.0371 0.1998 0.3629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0978 0.1183
Schistosoma mansoni hypothetical protein 0.0229 0.1178 0.1425
Brugia malayi Inositol-1 0.0115 0.052 0.1281
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0081 0.0098
Mycobacterium leprae Probable lipase LipE 0.0113 0.0505 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0011 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0138 0.0167
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0108 0.048 0.2957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0319 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0526 0.0966
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0137 0.0645 0.1108
Schistosoma mansoni ap endonuclease 0.008 0.0314 0.038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0138 0.0138
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.0978 0.2416
Leishmania major trypanothione reductase 0.0146 0.07 0.4023
Brugia malayi hypothetical protein 0.0158 0.077 0.19
Echinococcus multilocularis microtubule associated protein 2 0.1455 0.8269 0.8269
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0041 0.009 0.0109
Schistosoma mansoni hypothetical protein 0.0229 0.1178 0.1425
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.008 0.0314 0.0771
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0168 0.1862
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0137 0.0645 0.1108
Trypanosoma brucei trypanothione reductase 0.0146 0.07 0.4313
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0136 0.0641 0.0775
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0048 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0439 0.0806
Toxoplasma gondii NADPH-glutathione reductase 0.0051 0.0147 0.1626
Onchocerca volvulus 0.0237 0.1226 1
Schistosoma mansoni hypothetical protein 0.0229 0.1178 0.1425
Plasmodium falciparum thioredoxin reductase 0.0051 0.0147 0.184
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0198 0.0997 0.1206
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1185 0.1185
Echinococcus multilocularis ornithine aminotransferase 0.0137 0.0645 0.0645
Brugia malayi hypothetical protein 0.0035 0.0057 0.0133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Brugia malayi MH2 domain containing protein 0.0494 0.2709 0.6704
Echinococcus multilocularis dna polymerase eta 0.0039 0.0081 0.0081
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.0314 0.4307
Entamoeba histolytica exodeoxyribonuclease III, putative 0.008 0.0314 0.4879
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0051 0.0147 0.0893
Echinococcus granulosus Smad4 0.0034 0.0048 0.0059
Schistosoma mansoni gabp alpha 0.0073 0.0274 0.0332
Leishmania major hypothetical protein, conserved 0.0113 0.0505 0.2755
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0011 0.0049
Loa Loa (eye worm) glutathione reductase 0.0146 0.07 0.1726
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0274 0.0332
Brugia malayi beta-lactamase family protein 0.0113 0.0505 0.1243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0439 0.0806
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0102 0.0614
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Brugia malayi beta-lactamase family protein 0.0113 0.0505 0.1243
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0371 0.1998 0.3629
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0081 0.0485
Schistosoma mansoni cpg binding protein 0.01 0.0432 0.0522
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0232 0.028
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0051 0.0147 0.0357
Echinococcus multilocularis Aminotransferase class III 0.0137 0.0645 0.0645
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0102 0.0614
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0137 0.0645 0.1108
Loa Loa (eye worm) hypothetical protein 0.01 0.0432 0.1062
Brugia malayi glutathione reductase 0.0146 0.07 0.1726
Entamoeba histolytica hypothetical protein 0.0074 0.0283 0.4393
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0136 0.0641 0.3641
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0003 0.0003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0048 0.0048
Schistosoma mansoni ferritin 0.0034 0.005 0.0061
Brugia malayi Calcitonin receptor-like protein seb-1 0.0724 0.404 1
Schistosoma mansoni hypothetical protein 0.0047 0.0125 0.0152
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0283 0.0283
Mycobacterium ulcerans hypothetical protein 0.0962 0.5417 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0108 0.048 0.2957
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0334 0.1783 0.3228
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0505 0.1243
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0115 0.052 0.0875
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0505 0.061
Giardia lamblia NADH oxidase lateral transfer candidate 0.0051 0.0147 0.1177
Loa Loa (eye worm) hypothetical protein 0.0113 0.0505 0.1243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0439 0.0806
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0051 0.0147 0.018
Toxoplasma gondii target of rapamycin (TOR), putative 0.0101 0.0439 0.4921
Schistosoma mansoni ets-related 0.0221 0.113 0.1367
Brugia malayi latrophilin 2 splice variant baaae 0.0495 0.2716 0.6719
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0003 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0147 0.0893
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0041 0.009 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0439 0.0806
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0147 0.0893
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0081 0.0057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0081 0.0057
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.0334
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0051 0.0147 0.018
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0118 0.0285
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0641 0.158
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0064 0.0226 0.1382
Echinococcus multilocularis tumor protein p63 0.0683 0.3801 0.3801
Mycobacterium tuberculosis Conserved protein 0.0113 0.0505 0.0846
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0018 0.0021
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0041 0.009 0.1003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0102 0.0614
Echinococcus granulosus thioredoxin glutathione reductase 0.0146 0.07 0.0846
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0237 0.0287
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0232 0.0568
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0137 0.0645 1
Mycobacterium ulcerans L-lysine aminotransferase 0.0137 0.0645 0.1108
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0081 0.0098
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0137 0.0645 0.1108
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0136 0.0641 0.0775
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0041 0.009 0.0217
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0137 0.0645 0.1108
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0505 0.061
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0505 0.0846
Leishmania major phosphatidylinositol 3-kinase, putative 0.0046 0.0118 0.0239
Plasmodium vivax ornithine aminotransferase, putative 0.0137 0.0645 0.9192
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0037 0.0387
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0274 0.0673
Loa Loa (eye worm) hypothetical protein 0.0113 0.0505 0.1243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0118 0.0212
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0505 0.0846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.048 0.0881
Trichomonas vaginalis ap endonuclease, putative 0.008 0.0314 0.0575
Schistosoma mansoni ferritin 0.0034 0.005 0.0061
Trichomonas vaginalis ap endonuclease, putative 0.008 0.0314 0.0575
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0146 0.07 0.121
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.1618 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.008 0.0314 1
Trypanosoma brucei unspecified product 0.0039 0.0081 0.0485
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.052 0.3202
Brugia malayi Smad1 0.0034 0.0048 0.0113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0505 0.0846
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0505 0.0927
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0136 0.0641 0.3641
Brugia malayi RNA binding protein 0.0065 0.0232 0.0568
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0051 0.0147 0.0178
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0138 0.0167
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0041 0.009 0.0109
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0115 0.052 0.8108
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.1618 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0641 0.158
Schistosoma mansoni Smad4 0.0034 0.0048 0.0059
Brugia malayi Fli-1 protein 0.0221 0.113 0.2793
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0046 0.0118 0.0712
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0137 0.0645 0.1108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0439 0.0806
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0229 0.1178 0.1425
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.052 0.3202
Schistosoma mansoni microtubule-associated protein tau 0.1455 0.8269 1
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0962 0.5417 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0136 0.0331
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0103 0.045 0.0745
Brugia malayi Bromodomain containing protein 0.0039 0.008 0.0191
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0136 0.0641 0.3949
Trypanosoma cruzi trypanothione reductase, putative 0.0146 0.07 0.4313
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0081 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0278 0.0509
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0334 0.1783 0.3228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0319 0.0585
Brugia malayi Pre-SET motif family protein 0.0209 0.1061 0.2621
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0232 0.028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0978 0.1183
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0118 0.0285
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0026 0.0003 0.0003
Loa Loa (eye worm) RNA binding protein 0.0065 0.0232 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0081 0.0485
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.0118 0.0712
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0978 0.1183
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0081 0.0485
Trypanosoma brucei unspecified product 0.0027 0.0011 0.0049
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0115 0.052 0.5833
Echinococcus granulosus ornithine aminotransferase 0.0137 0.0645 0.078
Echinococcus multilocularis ornithine aminotransferase 0.0137 0.0645 0.0645
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.052 0.0955
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0283 0.0342
Echinococcus multilocularis dnaJ subfamily B 0.0874 0.4909 0.4909
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0505 0.3106
Echinococcus granulosus importin subunit beta 1 0.0029 0.0022 0.0027
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0046 0.0118 0.0712
Loa Loa (eye worm) hypothetical protein 0.0039 0.0081 0.0194
Schistosoma mansoni cpg binding protein 0.0093 0.039 0.0471
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0232 0.0232
Echinococcus multilocularis inositol monophosphatase 1 0.0115 0.052 0.052
Entamoeba histolytica hypothetical protein 0.0074 0.0283 0.4393
Echinococcus multilocularis expressed protein 0.0034 0.005 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0011 0.0049
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.052 0.2856
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0081 0.0194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.008 0.0314 0.1927
Schistosoma mansoni hypothetical protein 0.0311 0.1652 0.1998
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0689 0.4247
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0081 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0641 0.1178
Schistosoma mansoni ap endonuclease 0.008 0.0314 0.038
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.0314 0.4307
Echinococcus granulosus tumor protein p63 0.0683 0.3801 0.4596
Schistosoma mansoni hypothetical protein 0.0229 0.1178 0.1425
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0041 0.009 0.0217
Loa Loa (eye worm) hypothetical protein 0.0113 0.0505 0.1243
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0229 0.1178 0.2912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.048 0.0881
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0041 0.009 0.006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0037 0.0037
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0018 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0026 0.0031
Loa Loa (eye worm) histone methyltransferase 0.003 0.0026 0.0058
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0081 0.0098
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0051 0.0147 0.018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0136 0.0641 0.3949
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0274 0.0274
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0041 0.009 0.1003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.1618 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.008 0.0314 0.1927
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0041 0.009 0.0542
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0029 0.002 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.048 0.0881
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0168 0.2149
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0048 0.0113
Schistosoma mansoni ferritin light chain 0.0034 0.005 0.0061
Entamoeba histolytica hypothetical protein 0.0074 0.0283 0.4393
Plasmodium vivax thioredoxin reductase, putative 0.0146 0.07 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0137 0.0645 0.078
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0041 0.009 0.0542
Brugia malayi Thioredoxin reductase 0.0146 0.07 0.1726
Echinococcus multilocularis thioredoxin glutathione reductase 0.0146 0.07 0.07
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0505 0.0846
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0505 0.7121
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0783 0.1366
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.008 0.0314 0.0491
Loa Loa (eye worm) hypothetical protein 0.0072 0.0271 0.0666
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0026 0.0026
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0081 0.0485
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0136 0.0641 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0069 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0641 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0118 0.0212
Plasmodium falciparum glutathione reductase 0.0146 0.07 1
Brugia malayi CXXC zinc finger family protein 0.0093 0.039 0.0959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0365 0.0669
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0232 0.028
Brugia malayi Ets-domain containing protein 0.0073 0.0274 0.0673
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0156 0.095
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0041 0.009 0.1373
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0137 0.0645 0.1108
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0136 0.0641 0.0641

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.5 uM In vitro cytotoxic activity of the compound against human leukemic cell line K562 after incubation for 1 hour ChEMBL. 12781188
IC50 (functional) = 3.5 uM In vitro cytotoxic activity of the compound against human leukemic cell line K562 after incubation for 1 hour ChEMBL. 12781188
IC50 (functional) = 10 uM In vitro cytotoxic activity of the compound against human tumor cell line A2780 after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) = 10 uM In vitro cytotoxic activity of the compound against human tumor cell line A2780 after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) = 11 uM In vitro cytotoxic activity of the compound against human tumor cell line CH1 after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) = 11 uM In vitro cytotoxic activity of the compound against human tumor cell line SKOV-3 after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) = 11 uM In vitro cytotoxic activity of the compound against human tumor cell line CH1 after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) = 11 uM In vitro cytotoxic activity of the compound against human tumor cell line SKOV-3 after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) = 17.5 uM In vitro cytotoxic activity of the compound against human tumor cell line A2780CisR after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) = 17.5 uM In vitro cytotoxic activity of the compound against human tumor cell line A2780CisR after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) > 25 uM In vitro cytotoxic activity of the compound against human tumor cell line HT-29 after incubation for 96 hours ChEMBL. 12781188
IC50 (functional) > 25 uM In vitro cytotoxic activity of the compound against human tumor cell line HT-29 after incubation for 96 hours ChEMBL. 12781188

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12781188

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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