TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 394.507 | Formula: C24H30N2O3
H donors: 2 H acceptors: 3 LogP: 3.94 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: O=C[C@@H](NC(=O)C(NC(=O)CCc1ccccc1)(CC)CC)Cc1ccccc1
InChi: 1S/C24H30N2O3/c1-3-24(4-2,26-22(28)16-15-19-11-7-5-8-12-19)23(29)25-21(18-27)17-20-13-9-6-10-14-20/h5-14,18,21H,3-4,15-17H2,1-2H3,(H,25,29)(H,26,28)/t21-/m0/s1
InChiKey: DPQKVMMXFBIGGX-NRFANRHFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Calpain 1	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	hypothetical protein	Calpain 1	714 aa	716 aa	33.1 %
Schistosoma mansoni	calpain C (C02 family)	Calpain 1	714 aa	715 aa	33.4 %
Echinococcus granulosus	calpain	Calpain 1	714 aa	695 aa	38.6 %
Echinococcus multilocularis	calpain	Calpain 1	714 aa	695 aa	38.6 %
Echinococcus granulosus	calpain A	Calpain 1	714 aa	753 aa	31.5 %
Schistosoma japonicum	Calpain-9, putative	Calpain 1	714 aa	671 aa	33.8 %
Schistosoma mansoni	calpain (C02 family)	Calpain 1	714 aa	684 aa	31.0 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0043	0.0036	0.005
Toxoplasma gondii	cathepsin CPL	0.0057	0.0057	0.2548
Trypanosoma cruzi	cruzipain precursor, putative	0.0204	0.0265	1
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0057	0.0275
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0043	0.0036	0.0031
Schistosoma mansoni	hypothetical protein	0.0052	0.0049	0.0049
Onchocerca volvulus		0.0057	0.0057	0.0915
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0043	0.0036	0.0017
Mycobacterium ulcerans	TetR family transcriptional regulator	0.2833	0.3995	1
Loa Loa (eye worm)	ctsf protein	0.0057	0.0057	0.0275
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0057	0.0057	0.3724
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0043	0.0036	0.1239
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0043	0.0036	0.0032
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0057	0.0057	0.0053
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0054	0.0054
Echinococcus granulosus	cathepsin b	0.0175	0.0224	0.0221
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0146	0.0183	0.0183
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0029	0.0326
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0013	0.0376
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0004	0.0137
Loa Loa (eye worm)	cathepsin B	0.0064	0.0067	0.0323
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0045	0.0045
Trichomonas vaginalis	antibiotic synthetase, putative	0.0043	0.0036	0.0941
Onchocerca volvulus	Cathepsin L homolog	0.0057	0.0057	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0183	0.0887
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0055	0.0054	0.005
Loa Loa (eye worm)	hypothetical protein	0.004	0.0032	0.0156
Onchocerca volvulus		0.0057	0.0057	0.0915
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0043	0.0036	0.1359
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0013	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0036	0.0175
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0064	0.0067	0.2518
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0183	0.0887
Leishmania major	acetyl-CoA synthetase, putative	0.0043	0.0036	0.1239
Brugia malayi	CHE-14 protein	0.0041	0.0033	0.0162
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0036	0.0017
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0021	0.0782
Brugia malayi	cathepsin L-like precursor	0.004	0.0032	0.0156
Brugia malayi	hypothetical protein	0.0027	0.0013	0.0065
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0013	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0224	0.1087
Mycobacterium ulcerans	lipase LipD	0.0146	0.0183	0.0388
Mycobacterium leprae	conserved hypothetical protein	0.0146	0.0183	0.042
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0183	0.0887
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.0157	0.0762
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0145	0.0182	0.0384
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0017	0.000000098396	0.00000047636
Onchocerca volvulus	Cathepsin F homolog	0.0057	0.0057	0.0915
Brugia malayi	Cathepsin L-like precursor	0.0017	0.000000098396	0.00000047636
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0175	0.0224	0.0224
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0036	0.0017
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0029	0.0987
Brugia malayi	AMP-binding enzyme family protein	0.0043	0.0036	0.0175
Trypanosoma cruzi	cysteine peptidase, putative	0.0204	0.0265	1
Entamoeba histolytica	hypothetical protein	0.0221	0.0289	1
Echinococcus granulosus	survival motor neuron protein 1	0.1473	0.2066	0.2063
Schistosoma mansoni	hypothetical protein	0.0039	0.0031	0.0031
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0043	0.0036	0.1359
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.2833	0.3995	1
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0043	0.0036	0.0175
Loa Loa (eye worm)	calpain family protein 1	0.0039	0.003	0.0147
Schistosoma mansoni	hypothetical protein	0.0039	0.0031	0.0031
Loa Loa (eye worm)	cysteine protease	0.0057	0.0057	0.0275
Echinococcus granulosus	beta LACTamase domain containing family member	0.0146	0.0183	0.018
Loa Loa (eye worm)	hypothetical protein	0.0053	0.005	0.0243
Echinococcus multilocularis	calpain family protein 1, d	0.0039	0.003	0.0027
Echinococcus multilocularis	tumor protein p63	0.1395	0.1955	0.1952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Echinococcus granulosus	peptidase Clp S14 family	0.0054	0.0053	0.0049
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0113	0.0113
Echinococcus granulosus	expressed conserved protein	0.0089	0.0102	0.0099
Onchocerca volvulus		0.0043	0.0036	0.0371
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0057	0.1343
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0054	0.0053	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Trypanosoma cruzi	major cysteine proteinase, putative	0.0162	0.0205	0.7719
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0057	0.0275
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0029	0.0537
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0004	0.0137
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0064	0.0067	0.2414
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0083	0.0093	0.4705
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0146	0.0183	0.0402
Schistosoma mansoni	microtubule-associated protein tau	0.7066	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0043	0.0036	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0182	0.088
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0145	0.0182	0.6013
Leishmania major	hypothetical protein, conserved	0.0146	0.0183	0.6866
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0029	0.1111
Echinococcus granulosus	cathepsin b	0.0175	0.0224	0.0221
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0042	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0109	0.013	0.0628
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0054	0.0053	0.0073
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0043	0.0036	0.0031
Brugia malayi	AMP-binding enzyme family protein	0.0043	0.0036	0.0175
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0146	0.0183	0.0402
Echinococcus multilocularis	geminin	0.0378	0.0512	0.0509
Trichomonas vaginalis	esterase, putative	0.0146	0.0183	1
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0083	0.0093	0.009
Brugia malayi	cathepsin B-like cysteine proteinase	0.0175	0.0224	0.1087
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0187	0.0241	0.9075
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0004	0.0137
Schistosoma mansoni	cathepsin F (C01 family)	0.0057	0.0057	0.0057
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0043	0.0036	0.0031
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0145	0.0182	0.0398
Trypanosoma cruzi	cysteine protease, putative	0.0032	0.0021	0.0782
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0936	0.1303	0.3222
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0052	0.0049	0.0046
Trichomonas vaginalis	D-aminoacylase, putative	0.0146	0.0183	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0057	0.0057	0.2214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Mycobacterium leprae	Probable lipase LipE	0.0146	0.0183	0.042
Schistosoma mansoni	calpain-7 (C02 family)	0.0023	0.0008	0.0008
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0145	0.0182	0.0417
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0209	0.1012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0093	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0022	0.0106
Loa Loa (eye worm)	fibroinase	0.0057	0.0057	0.0275
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0175	0.0224	0.0224
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0103	0.0121	0.0245
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.002	0.0004	0.0137
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0043	0.0036	0.0571
Onchocerca volvulus		0.0301	0.0402	1
Schistosoma mansoni	hypothetical protein	0.0052	0.0049	0.0049
Mycobacterium tuberculosis	Probable lipase LipE	0.0146	0.0183	0.0402
Schistosoma mansoni	hypothetical protein	0.0127	0.0155	0.0155
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0057	0.0057	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0043	0.0036	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0013	0.0065
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.0111	0.3355
Leishmania major	acetyl-CoA synthetase, putative	0.0043	0.0036	0.1239
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Loa Loa (eye worm)	hypothetical protein	0.0109	0.013	0.0628
Schistosoma mansoni	Mername-AA248 (C02 family)	0.002	0.0004	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0057	0.0057	0.2214
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0004	0.0137
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0013	0.0735
Brugia malayi	Cathepsin L-like cysteine proteinase	0.004	0.0032	0.0156
Echinococcus multilocularis	expressed conserved protein	0.0089	0.0102	0.0099
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0183	0.6909
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0054	0.0053	0.0073
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0093	0.6876
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0036	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0053	0.005	0.005
Echinococcus multilocularis	cathepsin L cysteine protease	0.0057	0.0057	0.0053
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Brugia malayi	Probable ClpP-like protease	0.0083	0.0093	0.0452
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0093	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0182	0.088
Brugia malayi	AMP-binding enzyme family protein	0.0043	0.0036	0.0175
Brugia malayi	Cathepsin L-like precursor	0.004	0.0032	0.0156
Mycobacterium ulcerans	acyl-CoA synthetase	0.0145	0.0182	0.0384
Brugia malayi	AMP-binding enzyme family protein	0.0043	0.0036	0.0175
Onchocerca volvulus		0.0043	0.0036	0.0371
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0043	0.0036	0.133
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0146	0.0183	0.0887
Schistosoma mansoni	hypothetical protein	0.0301	0.0402	0.0402
Leishmania major	cathepsin L-like protease	0.0204	0.0265	1
Plasmodium vivax	vivapain-1	0.0032	0.0021	0.1132
Echinococcus multilocularis	survival motor neuron protein 1	0.1473	0.2066	0.2063
Echinococcus granulosus	geminin	0.0378	0.0512	0.0509
Brugia malayi	beta-lactamase	0.0146	0.0183	0.0887
Mycobacterium ulcerans	beta-lactamase	0.0146	0.0183	0.0388
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0064	0.0067	0.2414
Echinococcus granulosus	cysteine protease	0.0032	0.0021	0.0017
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0021	0.0782
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.0111	0.0107
Trichomonas vaginalis	D-aminoacylase, putative	0.0146	0.0183	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0103	0.0121	0.0245
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0033	0.003
Loa Loa (eye worm)	oxidoreductase	0.0043	0.0036	0.0175
Trichomonas vaginalis	penicillin-binding protein, putative	0.0146	0.0183	1
Schistosoma mansoni	calpain C (C02 family)	0.002	0.0004	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0145	0.0182	0.0384
Brugia malayi	hypothetical protein	0.0221	0.0289	0.1397
Leishmania major	cysteine peptidase A (CPA)	0.0057	0.0057	0.2029
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0146	0.0183	0.018
Leishmania major	cathepsin L-like protease	0.0057	0.0057	0.2029
Mycobacterium tuberculosis	Conserved protein	0.0146	0.0183	0.0402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Toxoplasma gondii	cathepsin B	0.0064	0.0067	0.3141
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0045	0.0218
Brugia malayi	cathepsin F-like cysteine proteinase	0.0017	0.000000098396	0.00000047636
Mycobacterium ulcerans	acyl-CoA synthetase	0.0145	0.0182	0.0384
Trichomonas vaginalis	antibiotic synthetase, putative	0.0043	0.0036	0.0941
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0057	0.0057	0.0275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0043	0.0036	0.005
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0137	0.017	0.0166
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0033	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0093	0.0452
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0083	0.0093	0.0194
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0145	0.0182	0.6013
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.0032	0.0427
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0145	0.0182	0.0384
Loa Loa (eye worm)	beta-lactamase	0.0146	0.0183	0.0887
Loa Loa (eye worm)	calpain	0.002	0.0004	0.0018
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.0057	0.1343
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0109	0.013	1
Echinococcus multilocularis	microtubule associated protein 2	0.7066	1	1
Echinococcus multilocularis	protein patched	0.0041	0.0033	0.003
Trypanosoma cruzi	cysteine peptidase, putative	0.0204	0.0265	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0057	0.0057	0.0053
Echinococcus granulosus	cathepsin l1	0.004	0.0032	0.0029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Onchocerca volvulus		0.0043	0.0036	0.0371
Leishmania major	cathepsin L-like protease	0.0057	0.0057	0.2029
Leishmania major	cathepsin L-like protease	0.0057	0.0057	0.2029
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0021	0.0021
Onchocerca volvulus		0.0057	0.0057	0.0915
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0043	0.0036	0.0017
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0146	0.0183	0.0183
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1646	0.2311	0.2308
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0045	0.0041
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0145	0.0182	0.0384
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0052	0.0049	0.0046
Entamoeba histolytica	hypothetical protein	0.0221	0.0289	1
Onchocerca volvulus		0.0057	0.0057	0.0915
Plasmodium vivax	calpain, putative	0.002	0.0004	0.0199
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0043	0.0036	0.0017
Entamoeba histolytica	acyl-coA synthetase, putative	0.0145	0.0182	0.6013
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0032	0.0021	0.0782
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0083	0.0093	0.4705
Mycobacterium tuberculosis	Probable hydrolase	0.0146	0.0183	0.0402
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0054	0.0054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0064	0.0067	0.2833
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0045	0.0045
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.0057	0.0275
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.0057	0.1343
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0029	0.0943
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0043	0.0036	0.0175
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0052	0.0049	0.0046
Echinococcus granulosus	tumor protein p63	0.1395	0.1955	0.1952
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0145	0.0182	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0109	0.013	0.0628
Plasmodium falciparum	acyl-CoA synthetase	0.0109	0.013	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0004	0.0137
Schistosoma mansoni	patched 1	0.0041	0.0033	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0221	0.0289	0.0285
Echinococcus granulosus	cathepsin L	0.0032	0.0021	0.0017
Loa Loa (eye worm)	inositol-1	0.0038	0.0029	0.0143
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0043	0.0036	0.1967
Plasmodium vivax	vivapain-2	0.0057	0.0057	0.3096
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0057	0.0057	0.3724
Trypanosoma brucei	hypothetical protein, conserved	0.0146	0.0183	0.6866
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0032	0.0704
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.0111	0.0107
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0043	0.0036	0.0017
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0037	0.0028	0.001
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0036	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0183	0.0887
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	0.2833	0.3995	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0083	0.0093	0.009
Schistosoma mansoni	calpain-7 (C02 family)	0.0023	0.0008	0.0008
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0036	0.0017
Brugia malayi	Inositol-1	0.0038	0.0029	0.0143
Schistosoma mansoni	hypothetical protein	0.0113	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0182	0.088
Loa Loa (eye worm)	hypothetical protein	0.004	0.0032	0.0156
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0045	0.0041
Giardia lamblia	Cathepsin B precursor	0.0064	0.0067	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0146	0.0183	1
Entamoeba histolytica	hypothetical protein	0.0221	0.0289	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0032	0.0704
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0043	0.0036	0.0032
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0127	0.0155	0.0152
Toxoplasma gondii	propionate-CoA ligase	0.0043	0.0036	0.133
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0021	0.0021
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0054	0.0053	0.0092
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0103	0.0121	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0109	0.013	0.0628
Schistosoma mansoni	acetyl-CoA synthetase	0.0043	0.0036	0.0036
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0045	0.0041
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0043	0.0036	0.1359
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0033	0.003
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0021	0.0021
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0033	0.003
Loa Loa (eye worm)	hypothetical protein	0.0109	0.013	0.0628
Echinococcus multilocularis	cathepsin b	0.0175	0.0224	0.0221
Mycobacterium tuberculosis	Probable esterase LipL	0.0146	0.0183	0.0402
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0029	0.1111
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0175	0.0224	0.0224
Schistosoma mansoni	thyroid hormone receptor	0.0137	0.017	0.017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Brugia malayi	calpain family protein 1	0.0053	0.005	0.0243
Brugia malayi	calpain family protein 1	0.0053	0.005	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0183	0.0887
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0004	0.0137
Echinococcus multilocularis	GPCR, family 2	0.0052	0.0049	0.0046
Mycobacterium ulcerans	esterase/lipase LipP	0.0146	0.0183	0.0388
Trypanosoma cruzi	cysteine peptidase, putative	0.0204	0.0265	1
Giardia lamblia	Cathepsin B precursor	0.0064	0.0067	0.5
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0043	0.0036	0.1944
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0043	0.0036	0.0031
Brugia malayi	Cathepsin L-like precursor	0.004	0.0032	0.0156
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0045	0.0041
Brugia malayi	AMP-binding enzyme family protein	0.0145	0.0182	0.088
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0049	0.0239
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0013	0.0376
Brugia malayi	AMP-binding enzyme family protein	0.0145	0.0182	0.088
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0042	0.0202
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.0111	0.0536
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0029	0.0537
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0057	0.0057	0.0275
Brugia malayi	beta-lactamase family protein	0.0146	0.0183	0.0887
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.0169	0.0165
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0043	0.0036	0.0017
Schistosoma mansoni	cellular tumor antigen P53	0.0204	0.0265	0.0265
Onchocerca volvulus		0.0204	0.0265	0.6403
Loa Loa (eye worm)	hypothetical protein	0.1473	0.2066	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0145	0.0182	0.0417
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0057	0.0057	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0033	0.0162
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0004	0.0137
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0057	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0183	0.0887
Onchocerca volvulus		0.0043	0.0036	0.0371
Brugia malayi	beta-lactamase family protein	0.0146	0.0183	0.0887
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0052	0.0049	0.0239
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0183	0.6909
Onchocerca volvulus		0.0057	0.0057	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0204	0.0265	0.1284
Toxoplasma gondii	ABC1 family protein	0.0146	0.0183	1
Mycobacterium tuberculosis	Conserved protein	0.0146	0.0183	0.0402
Onchocerca volvulus		0.0146	0.0183	0.4247
Leishmania major	4-coumarate:coa ligase-like protein	0.0145	0.0182	0.681
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0301	0.0402	0.1945
Leishmania major	4-coumarate:coa ligase-like protein	0.0145	0.0182	0.681
Loa Loa (eye worm)	hypothetical protein	0.005	0.0047	0.0225
Schistosoma mansoni	hypothetical protein	0.0039	0.0031	0.0031
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0045	0.0218
Plasmodium vivax	hypothetical protein, conserved	0.0146	0.0183	1
Plasmodium vivax	vivapain-2	0.0057	0.0057	0.3096
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0004	0.0137
Onchocerca volvulus		0.004	0.0032	0.0269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0036	0.0017
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0021	0.01
Onchocerca volvulus		0.0146	0.0183	0.4247
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0103	0.0121	0.0245
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0029	0.0026
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0093	0.0161
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0016	0.0225
Trichomonas vaginalis	D-aminoacylase, putative	0.0146	0.0183	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0043	0.0036	0.0175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.0057	0.2139
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0109	0.013	0.0267
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0064	0.0067	0.0067
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0029	0.0987
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0052	0.0049	0.0239
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0083	0.0093	0.5094
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0093	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0109	0.013	0.0253
Schistosoma mansoni	hypothetical protein	0.0052	0.0049	0.0049
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0043	0.0036	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Echinococcus granulosus	calpain A	0.0055	0.0054	0.005
Schistosoma mansoni	transcription factor LCR-F1	0.0221	0.0289	0.0289
Echinococcus multilocularis	calpain A	0.0055	0.0054	0.005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Echinococcus granulosus	cathepsin l1	0.0057	0.0057	0.0053
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0221	0.0289	0.0285
Onchocerca volvulus		0.0146	0.0183	0.4247
Echinococcus granulosus	cathepsin L cysteine protease	0.0032	0.0021	0.0017
Schistosoma mansoni	cathepsin F (C01 family)	0.004	0.0032	0.0032
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.0157	0.0762
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0145	0.0182	0.0384
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0021	0.01
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0165	0.0209	0.1012
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0146	0.0183	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0135	0.0654
Schistosoma mansoni	hypothetical protein	0.0378	0.0512	0.0512
Echinococcus multilocularis	cysteine protease	0.0057	0.0057	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0057	0.2214
Onchocerca volvulus		0.0057	0.0057	0.0915
Schistosoma mansoni	cathepsin F (C01 family)	0.0057	0.0057	0.0057
Schistosoma mansoni	thyroid hormone receptor	0.0137	0.017	0.017
Leishmania major	cathepsin L-like protease	0.0057	0.0057	0.2029
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0004	0.0137
Giardia lamblia	Cathepsin B precursor	0.0064	0.0067	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0057	0.0057	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0036	0.0175
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0165	0.0209	0.1012
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0043	0.0036	0.0031
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0032	0.0021	0.0627
Echinococcus multilocularis	cysteine protease	0.0057	0.0057	0.0053
Plasmodium vivax	acyl-CoA synthetase, putative	0.0109	0.013	0.7074
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0043	0.0036	0.133
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0146	0.0183	0.0887
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.0169	0.0165
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0029	0.0016	0.0878
Loa Loa (eye worm)	hypothetical protein	0.0039	0.003	0.0147
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0043	0.0036	0.0031
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0175	0.0224	0.846
Brugia malayi	MH2 domain containing protein	0.0128	0.0157	0.0762
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0057	0.0275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Entamoeba histolytica	hypothetical protein	0.0221	0.0289	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0145	0.0182	0.681
Plasmodium vivax	vivapain-3	0.0032	0.0021	0.1132
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0057	0.0275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.0265	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0045	0.0045
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0029	0.0537
Brugia malayi	calpain 7	0.002	0.0004	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0033	0.0782
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0021	0.0782
Schistosoma mansoni	hypothetical protein	0.0039	0.0031	0.0031
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0029	0.0026
Leishmania major	cathepsin L-like protease	0.0204	0.0265	1
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0057	0.0275
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0127	0.0155	0.0152
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0029	0.0029
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0043	0.0036	0.0175
Mycobacterium tuberculosis	Conserved protein	0.0146	0.0183	0.0402
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0043	0.0036	0.0031
Echinococcus multilocularis	cathepsin b	0.0175	0.0224	0.0221
Echinococcus multilocularis	cathepsin L	0.0032	0.0021	0.0017
Brugia malayi	hypothetical protein	0.1473	0.2066	1
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0043	0.0036	0.0017
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0043	0.0036	0.0017
Mycobacterium ulcerans	acyl-CoA synthetase	0.0145	0.0182	0.0384
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0021	0.0654
Brugia malayi	AMP-binding enzyme family protein	0.0145	0.0182	0.088
Loa Loa (eye worm)	hypothetical protein	0.004	0.0032	0.0156
Schistosoma mansoni	calpain (C02 family)	0.002	0.0004	0.0004
Onchocerca volvulus	Cathepsin L homolog	0.0057	0.0057	0.0915
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.2833	0.3995	1
Plasmodium vivax	unspecified product	0.0032	0.0021	0.1132
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0029	0.0029
Mycobacterium ulcerans	transcriptional regulator	0.2833	0.3995	1
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0043	0.0036	0.0031
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0043	0.0036	0.005
Onchocerca volvulus		0.0057	0.0057	0.0915
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0052	0.0049	0.0046
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0043	0.0036	0.0017
Schistosoma mansoni	hypothetical protein	0.0052	0.0049	0.0049
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0043	0.0036	0.1239
Leishmania major	cathepsin L-like protease	0.0057	0.0057	0.2029
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0043	0.0036	0.0031
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0036	0.0017
Brugia malayi	latrophilin 2 splice variant baaae	0.0113	0.0135	0.0654
Schistosoma mansoni	peptidase Clp (S14 family)	0.0083	0.0093	0.0093
Brugia malayi	Latrophilin receptor protein 2	0.0052	0.0049	0.0239
Echinococcus granulosus	GPCR family 2	0.0052	0.0049	0.0046
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0036	0.0017
Leishmania major	cathepsin L-like protease	0.0204	0.0265	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0024	0.0019
Schistosoma mansoni	hypothetical protein	0.0378	0.0512	0.0512
Mycobacterium tuberculosis	Probable lipase LipD	0.0146	0.0183	0.0402
Loa Loa (eye worm)	calpain family protein 1	0.0053	0.005	0.0243
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0175	0.0224	0.0224
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0043	0.0036	0.1239
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0043	0.0036	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0057	0.2214
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0111	0.0536
Onchocerca volvulus		0.0145	0.0182	0.4209
Schistosoma mansoni	hypothetical protein	0.0221	0.0289	0.0289
Toxoplasma gondii	hypothetical protein	0.0029	0.0016	0.0154
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0057	0.0057	0.0053
Schistosoma mansoni	survival motor neuron protein	0.0301	0.0402	0.0402
Mycobacterium ulcerans	hypothetical protein	0.0146	0.0183	0.0388
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0055	0.0054	0.005
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0146	0.0183	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0057	0.0275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0021	0.0654
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0165	0.0209	0.1012

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.08 uM	Inhibition of pig erythrocyte mu-calpain	ChEMBL.	18694642
Ki (binding)	= 2.91 uM	Inhibition of human liver cathepsin B	ChEMBL.	18694642

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL513049

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1010307