Detailed information for compound 1030692

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.265 | Formula: C16H23Cl2NO2
  • H donors: 1 H acceptors: 1 LogP: 3.81 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1[C@H](N2CCCCC2)c2cc(Cl)ccc2OC1(C)C.Cl
  • InChi: 1S/C16H22ClNO2.ClH/c1-16(2)15(19)14(18-8-4-3-5-9-18)12-10-11(17)6-7-13(12)20-16;/h6-7,10,14-15,19H,3-5,8-9H2,1-2H3;1H/t14-,15+;/m1./s1
  • InChiKey: RTLYFCZTVGCBLG-LIOBNPLQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0236 0.1975 0.3668
Onchocerca volvulus 0.0165 0.1355 0.1952
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.035 0.2981 0.4686
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Brugia malayi nuclear hormone receptor 0.0165 0.1355 0.2517
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0913 0.1447
Loa Loa (eye worm) hypothetical protein 0.0093 0.0723 0.1342
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0078 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2166 0.3496
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0623 0.5385 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0033 0.0194 0.0488
Brugia malayi nuclear receptor NHR-88 0.0165 0.1355 0.2517
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0428 0.1191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0707 0.1064
Entamoeba histolytica Ran family GTPase 0.0023 0.0104 0.0224
Brugia malayi orphan nuclear receptor NR2E1 0.0165 0.1355 0.2517
Brugia malayi photoreceptor-specific nuclear receptor 0.035 0.2981 0.5536
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0033 0.0194 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.2644 0.7711
Brugia malayi Nuclear hormone receptor-like 1 0.0185 0.1529 0.284
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0707 0.1312
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0125 0.0999 0.287
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0194 0.0271
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0125 0.0999 0.0999
Entamoeba histolytica hypothetical protein 0.0019 0.0069 0.0121
Schistosoma mansoni kinase 0.0203 0.1691 0.1691
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1388 0.2223
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0165 0.1355 0.1355
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0125 0.0999 0.286
Brugia malayi Nuclear hormone receptor family member nhr-25 0.035 0.2981 0.5536
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0104 0.0157
Mycobacterium tuberculosis Conserved protein 0.0115 0.0913 0.1064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.035 0.2981 0.5536
Loa Loa (eye worm) nuclear receptor NHR-67 0.0165 0.1355 0.2517
Brugia malayi serine/threonine-protein kinase plk-2 0.04 0.3421 0.6352
Brugia malayi PXA domain containing protein 0.0019 0.0069 0.0129
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0033 0.0194 0.0488
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0069 0.0069
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0091 0.0708 0.1315
Trypanosoma brucei polo-like protein kinase 0.04 0.3421 1
Brugia malayi glutaminase DH11.1 0.0558 0.4815 0.8941
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0125 0.0999 0.3259
Echinococcus multilocularis glutamate synthase 0.0033 0.0194 0.0256
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0326 0.0605
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0081 0.0081
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0125 0.0999 0.1855
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0078 0.0078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.0913 0.1696
Echinococcus multilocularis cysteine protease atg4b 0.006 0.0428 0.0565
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.082 0.7115 0.8974
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0125 0.0158
Leishmania major hypothetical protein, conserved 0.0115 0.0913 0.2608
Brugia malayi beta-lactamase family protein 0.0115 0.0913 0.1696
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0125 0.0999 0.1174
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0913 0.2608
Brugia malayi Phospholipase A2 family protein 0.0093 0.0723 0.1342
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0138 0.0256
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0033 0.0194 0.0292
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0165 0.1355 0.1786
Loa Loa (eye worm) glutaminase 2 0.0558 0.4815 0.8941
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0913 0.1447
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0033 0.0194 0.0292
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0033 0.0194 0.0147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0999 0.286
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.035 0.2981 0.5536
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0125 0.0999 0.287
Schistosoma mansoni zinc finger protein 0.0165 0.1355 0.1355
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.035 0.2981 0.4489
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0471 0.0874
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0033 0.0194 0.0256
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0125 0.0284
Echinococcus multilocularis FTZ F1 alpha 0.035 0.2981 0.3929
Mycobacterium ulcerans glutaminase 0.0558 0.4815 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0033 0.0194 0.0633
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0069 0.0069
Schistosoma mansoni sulfide quinone reductase 0.0033 0.0194 0.0194
Echinococcus granulosus thyroid hormone receptor alpha 0.0165 0.1355 0.204
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.006 0.0428 0.0428
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0185 0.1529 0.284
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0078 0.0082
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.0913 0.1375
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1388 0.2223
Trichomonas vaginalis mercuric reductase, putative 0.0125 0.0999 0.1587
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0078 0.0147
Loa Loa (eye worm) glutathione reductase 0.0359 0.3065 0.5692
Entamoeba histolytica peptidase, C54 family 0.0023 0.0108 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.035 0.2981 0.5536
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0078 0.0118
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0033 0.0194 0.036
Loa Loa (eye worm) beta-lactamase 0.0115 0.0913 0.1696
Schistosoma mansoni sulfide quinone reductase 0.0033 0.0194 0.0194
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.2821 0.5238
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0028 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0069 0.0067
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0033 0.0194 0.0147
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0069 0.0092
Loa Loa (eye worm) inositol-1 0.0037 0.0227 0.0421
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0911 0.792 1
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2166 0.3496
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1388 0.2223
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0069 0.0092
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0033 0.0194 0.0488
Giardia lamblia NADH oxidase lateral transfer candidate 0.0125 0.0999 0.292
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0125 0.0999 0.1943
Loa Loa (eye worm) hypothetical protein 0.035 0.2981 0.5536
Loa Loa (eye worm) hypothetical protein 0.0089 0.0689 0.128
Toxoplasma gondii selenide, water dikinase 0.0033 0.0194 0.0633
Entamoeba histolytica serine/threonine protein kinase, putative 0.04 0.3421 1
Schistosoma mansoni microtubule-associated protein tau 0.0766 0.6642 0.6642
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1388 0.2223
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0125 0.0999 0.1943
Onchocerca volvulus Serine\/threonine kinase homolog 0.04 0.3421 0.5425
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0081 0.015
Plasmodium falciparum glutathione reductase 0.0359 0.3065 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.035 0.2981 0.5536
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0185 0.1529 0.2303
Echinococcus granulosus nuclear receptor nhr 48 0.0165 0.1355 0.204
Echinococcus multilocularis dna polymerase eta 0.002 0.0078 0.0103
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0033 0.0194 0.0633
Echinococcus granulosus glutamate synthase 0.0033 0.0194 0.0292
Schistosoma mansoni hypothetical protein 0.0354 0.3016 0.3016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0165 0.1355 0.1786
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0033 0.0194 0.0633
Trypanosoma brucei trypanothione reductase 0.0359 0.3065 0.8952
Schistosoma mansoni nuclear receptor nhr-48 0.0165 0.1355 0.1355
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0089 0.0689 0.0689
Schistosoma mansoni nuclear hormone receptor 0.0165 0.1355 0.1355
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0069 0.0105
Leishmania major importin beta-1 subunit, putative 0.0025 0.0125 0.0284
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.035 0.2981 0.5536
Brugia malayi hypothetical protein 0.0019 0.0069 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0078 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Leishmania major hypothetical protein, conserved 0.0033 0.0194 0.0488
Toxoplasma gondii thioredoxin reductase 0.0359 0.3065 1
Schistosoma mansoni hypothetical protein 0.0048 0.0326 0.0326
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0033 0.0194 0.0244
Brugia malayi nuclear receptor RXR 0.0185 0.1529 0.284
Brugia malayi nuclear receptor NHR-67 0.0165 0.1355 0.2517
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0033 0.0194 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0069 0.0067
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0125 0.0999 0.287
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.0913 0.2617
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1201 0.3455
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1201 0.3455
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0033 0.0194 0.0194
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0033 0.0194 0.0244
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0185 0.1529 0.2015
Onchocerca volvulus 0.0048 0.0324 0.0218
Echinococcus granulosus retinoic acid receptor rxr beta a 0.035 0.2981 0.4489
Schistosoma mansoni coup transcription factor 0.035 0.2981 0.2981
Trichomonas vaginalis CAMK family protein kinase 0.04 0.3421 0.5549
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0033 0.0194 0.0244
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.1932 0.3589
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0108 0.0247
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0081 0.015
Leishmania major hypothetical protein, conserved 0.0033 0.0194 0.0488
Loa Loa (eye worm) hypothetical protein 0.0185 0.1529 0.284
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0033 0.0194 0.0001
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0165 0.1355 0.1355
Loa Loa (eye worm) programmed cell death 8 0.0033 0.0194 0.036
Schistosoma mansoni retinoic acid receptor RXR 0.035 0.2981 0.2981
Echinococcus multilocularis dna polymerase kappa 0.002 0.0078 0.0103
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0125 0.0999 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0324 0.0324
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0689 0.225
Onchocerca volvulus Huntingtin homolog 0.0122 0.0977 0.1316
Trichomonas vaginalis CAMK family protein kinase 0.04 0.3421 0.5549
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0397 0.0738
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0033 0.0194 0.0147
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0104 0.0138
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.035 0.2981 0.3929
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0129
Leishmania major hypothetical protein, conserved 0.0033 0.0194 0.0488
Brugia malayi Thioredoxin reductase 0.0359 0.3065 0.5692
Loa Loa (eye worm) hypothetical protein 0.0115 0.0913 0.1696
Schistosoma mansoni glutamate synthase 0.0033 0.0194 0.0194
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0069 0.0092
Mycobacterium tuberculosis Probable dehydrogenase 0.082 0.7115 0.8974
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0069 0.0069
Schistosoma mansoni ran 0.0023 0.0104 0.0104
Schistosoma mansoni thyroid hormone receptor 0.035 0.2981 0.2981
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2166 0.3496
Brugia malayi hypothetical protein 0.0165 0.1355 0.2517
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0069 0.0069
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.035 0.2981 0.3929
Echinococcus granulosus dna polymerase kappa 0.002 0.0078 0.0118
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0091 0.0708 0.1315
Schistosoma mansoni glutaminase 0.0558 0.4815 0.4815
Entamoeba histolytica hypothetical protein 0.0025 0.0125 0.0284
Entamoeba histolytica peptidase, C54 family 0.0023 0.0108 0.0235
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0108 0.0235
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0125 0.0999 0.286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0707 0.0707
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.2644 0.7711
Schistosoma mansoni ran 0.0023 0.0104 0.0104
Giardia lamblia Glutamate synthase 0.0033 0.0194 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0069 0.0069
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0471 0.1304
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0033 0.0194 0.0292
Brugia malayi follicle stimulating hormone receptor 0.0231 0.1932 0.3589
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.0913 0.1762
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0108 0.0235
Schistosoma mansoni nuclear receptor 0.0165 0.1355 0.1355
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0078 0.0147
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0104 0.0224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.035 0.2981 0.3929
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0138 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0069 0.0067
Brugia malayi steroid hormone receptor 0.035 0.2981 0.5536
Loa Loa (eye worm) hypothetical protein 0.0115 0.0913 0.1696
Brugia malayi conserved hypotetical protein 0.0165 0.1355 0.2517
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0033 0.0194 0.0256
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0177 0.0449
Leishmania major mitochondrial DNA polymerase beta 0.0312 0.2644 0.7711
Brugia malayi Pre-SET motif family protein 0.0623 0.5385 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0125 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1388 0.2223
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0078 0.0082
Loa Loa (eye worm) hypothetical protein 0.0442 0.3795 0.7048
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0033 0.0194 0.0488
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0165 0.1355 0.1952
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1347 0.1618
Loa Loa (eye worm) hypothetical protein 0.035 0.2981 0.5536
Loa Loa (eye worm) RecQ helicase 0.0027 0.0138 0.0256
Mycobacterium ulcerans hypothetical protein 0.0164 0.1347 0.2679
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.006 0.0428 0.0428
Leishmania major trypanothione reductase 0.0359 0.3065 0.8951
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0069 0.0105
Loa Loa (eye worm) hypothetical protein 0.0122 0.0977 0.1814
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0033 0.0194 0.0001
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0033 0.0194 0.0488
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0104 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.1645 0.2643
Loa Loa (eye worm) glutaminase 0.0558 0.4815 0.8941
Onchocerca volvulus Bile acid receptor homolog 0.035 0.2981 0.4686
Mycobacterium tuberculosis Conserved protein 0.0115 0.0913 0.1064
Schistosoma mansoni steroid hormone receptor ad4bp 0.035 0.2981 0.2981
Echinococcus multilocularis expressed protein 0.0368 0.314 0.4138
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0033 0.0194 0.0147
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0227 0.0407
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0999 0.286
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0125 0.0158
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0125 0.0999 0.1943
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0078 0.016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0999 0.286
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0033 0.0194 0.0488
Onchocerca volvulus 0.0115 0.0913 0.1209
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0069 0.0105
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.0913 0.1064
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.2166 0.4022
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.0913 0.1064
Schistosoma mansoni glutamate synthase 0.0033 0.0194 0.0194
Mycobacterium ulcerans beta-lactamase 0.0115 0.0913 0.1762
Brugia malayi Importin beta-1 subunit 0.0031 0.0177 0.0328
Trypanosoma cruzi trypanothione reductase, putative 0.0359 0.3065 0.8951
Echinococcus granulosus thioredoxin glutathione reductase 0.0361 0.3079 0.4635
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0033 0.0194 0.036
Leishmania major GTP-binding protein, putative 0.0023 0.0104 0.0224
Schistosoma mansoni importin beta-1 0.0031 0.0177 0.0177
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.035 0.2981 0.4489
Echinococcus granulosus FTZ F1 alpha 0.035 0.2981 0.4489
Loa Loa (eye worm) hypothetical protein 0.035 0.2981 0.5536
Leishmania major DNA polymerase kappa, putative 0.002 0.0078 0.0147
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0471 0.0501
Toxoplasma gondii hypothetical protein 0.005 0.0345 0.1127
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0999 0.286
Loa Loa (eye worm) hypothetical protein 0.0048 0.0324 0.0601
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0033 0.0194 0.0441
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Onchocerca volvulus Huntingtin homolog 0.0122 0.0977 0.1316
Onchocerca volvulus Phospholipase A2 homolog 0.0442 0.3795 0.6055
Loa Loa (eye worm) hypothetical protein 0.0115 0.0913 0.1696
Echinococcus multilocularis Peptidase C54 0.006 0.0428 0.0565
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0428 0.0654
Trichomonas vaginalis CAMK family protein kinase 0.04 0.3421 0.5549
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0913 0.1447
Echinococcus multilocularis tumor protein p63 0.0326 0.2775 0.3657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0689 0.0689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.035 0.2981 0.5536
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0193 0.0146
Brugia malayi nuclear hormone receptor family member odr-7 0.0165 0.1355 0.2517
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.04 0.3421 1
Onchocerca volvulus 0.035 0.2981 0.4686
Plasmodium vivax thioredoxin reductase, putative 0.0359 0.3065 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0227 0.0342
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0125 0.0999 0.286
Treponema pallidum NADH oxidase 0.0125 0.0999 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0428 0.0654
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.035 0.2981 0.5536
Brugia malayi Nuclear hormone receptor-like 1 0.035 0.2981 0.5536
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0033 0.0194 0.0441
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0165 0.1355 0.2517
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0069 0.0092
Onchocerca volvulus 0.0709 0.6142 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.035 0.2981 0.5536
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.035 0.2981 0.3929
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0289 0.0767
Loa Loa (eye worm) hypothetical protein 0.0115 0.0913 0.1696
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Brugia malayi beta-lactamase 0.0115 0.0913 0.1696
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1201 0.3464
Entamoeba histolytica hypothetical protein 0.0019 0.0069 0.0121
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0033 0.0194 0.0244
Schistosoma mansoni nuclear hormone receptor 0.0165 0.1355 0.1355
Schistosoma mansoni glutamate synthase 0.0033 0.0194 0.0194
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.0913 0.1064
Brugia malayi glutathione reductase 0.0359 0.3065 0.5692
Loa Loa (eye worm) hypothetical protein 0.035 0.2981 0.5536
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0078 0.016
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.0913 0.1064
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Schistosoma mansoni thyroid hormone receptor 0.035 0.2981 0.2981
Leishmania major DNA polymerase eta, putative 0.002 0.0078 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0078 0.016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0227 0.0585
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0078 0.0103
Mycobacterium tuberculosis Probable oxidoreductase 0.0911 0.792 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0194 0.0271
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0033 0.0194 0.0256
Brugia malayi hypothetical protein 0.0019 0.0069 0.0129
Plasmodium falciparum glutathione reductase 0.0125 0.0999 0.3259
Schistosoma mansoni survival motor neuron protein 0.0048 0.0326 0.0326
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0069 0.0105
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0033 0.0194 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-25 0.035 0.2981 0.5536
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0194 0.0488
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0165 0.1355 0.204
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0125 0.0999 0.3259
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1468 0.2354
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0078 0.0147
Loa Loa (eye worm) hypothetical protein 0.006 0.0428 0.0796
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0733 0.6355 0.8004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.0913 0.1696
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0033 0.0194 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1468 0.2354
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0428 0.0654
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0069 0.0105
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0081 0.015
Trichomonas vaginalis esterase, putative 0.0115 0.0913 0.1447
Brugia malayi Inositol-1 0.0037 0.0227 0.0421
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0033 0.0194 0.0633
Onchocerca volvulus Phospholipase A2 homolog 0.0093 0.0723 0.0889
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0078 0.0146
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0177 0.0449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0707 0.0707
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0078 0.0147
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0033 0.0194 0.0567
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0125 0.0999 0.286
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0471 0.0621
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0661 0.0995
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0227 0.0597
Trypanosoma cruzi polo-like protein kinase, putative 0.04 0.3421 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0069 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0289 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-31 0.035 0.2981 0.5536
Mycobacterium ulcerans lipase LipD 0.0115 0.0913 0.1762
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0033 0.0194 0.0147
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.04 0.3421 0.4508
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.082 0.7115 0.8974
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0104 0.0194
Onchocerca volvulus 0.0115 0.0913 0.1209
Echinococcus granulosus nuclear receptor 2DBD gamma 0.035 0.2981 0.4489
Plasmodium vivax SET domain protein, putative 0.0089 0.0689 0.209
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0033 0.0194 0.0501
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0125 0.0999 0.3259
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1975 0.2973
Mycobacterium tuberculosis Probable reductase 0.082 0.7115 0.8974
Loa Loa (eye worm) hypothetical protein 0.0134 0.1083 0.2012
Brugia malayi nuclear receptor NHR-88 0.035 0.2981 0.5536
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0194 0.0271
Echinococcus granulosus Peptidase C54 0.006 0.0428 0.0645
Loa Loa (eye worm) DR-78 0.0165 0.1355 0.2517
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0312 0.2644 0.7714
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0373 0.1016
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.082 0.7115 0.8958
Trypanosoma brucei unspecified product 0.002 0.0078 0.016
Trypanosoma cruzi NADH dehydrogenase, putative 0.0033 0.0194 0.0488
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0069 0.0092
Plasmodium vivax ferrodoxin reductase, putative 0.0033 0.0194 0.0441
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.082 0.7115 0.8974
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.035 0.2981 0.5536
Loa Loa (eye worm) hypothetical protein 0.0033 0.0194 0.036
Trichomonas vaginalis CAMK family protein kinase 0.04 0.3421 0.5549
Echinococcus multilocularis thyroid hormone receptor alpha 0.035 0.2981 0.3929
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0428 0.0654
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.0913 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0069 0.0067
Mycobacterium ulcerans hypothetical protein 0.0115 0.0913 0.1762
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1975 0.2603
Brugia malayi Peptidase family C54 containing protein 0.006 0.0428 0.0796
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0069 0.0129
Schistosoma mansoni hypothetical protein 0.0332 0.2821 0.2821
Schistosoma mansoni RAR-like nuclear receptor 0.035 0.2981 0.2981
Echinococcus multilocularis ecdysone induced protein 78C 0.035 0.2981 0.3929
Mycobacterium ulcerans NADH dehydrogenase 0.0033 0.0194 0.0244
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0185 0.1529 0.1529
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0911 0.792 1
Toxoplasma gondii ABC1 family protein 0.0115 0.0913 0.2979
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0874 0.7589 1
Schistosoma mansoni disulfide oxidoreductase 0.0033 0.0194 0.0194
Brugia malayi beta-lactamase family protein 0.0115 0.0913 0.1696
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0227 0.0299
Loa Loa (eye worm) hypothetical protein 0.0185 0.1529 0.284
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0125 0.0999 0.286
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0227 0.0585
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0129
Echinococcus multilocularis thioredoxin glutathione reductase 0.0361 0.3079 0.4057
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0104 0.0237
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0033 0.0194 0.0256
Trypanosoma cruzi trypanothione reductase, putative 0.0125 0.0999 0.286
Brugia malayi nuclear receptor RXR 0.0165 0.1355 0.2517
Echinococcus granulosus Nuclear hormone receptor HR96 0.0165 0.1355 0.204
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0194 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0689 0.0689
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0109 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.04 0.3421 0.5549
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0033 0.0194 0.0633
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0125 0.0999 0.1316
Schistosoma mansoni serine/threonine protein kinase 0.04 0.3421 0.3421
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0913 0.1447
Leishmania major NADH dehydrogenase, putative 0.0033 0.0194 0.0488
Brugia malayi Steroid receptor seven-up type 2 0.035 0.2981 0.5536
Toxoplasma gondii NADPH-glutathione reductase 0.0125 0.0999 0.3259
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0227 0.0324
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0129
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0428 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0081 0.0081
Entamoeba histolytica disulphide oxidoreductase, putative 0.0033 0.0194 0.0488
Trichomonas vaginalis apoptosis inducing factor, putative 0.0033 0.0194 0.0271
Entamoeba histolytica thioredoxin reductase, putative 0.0033 0.0194 0.0488
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0033 0.0194 0.0001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0125 0.0999 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0227 0.0227
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0033 0.0194 0.0501
Brugia malayi tailless protein 0.0165 0.1355 0.2517
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0104 0.0305
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0707 0.1312
Loa Loa (eye worm) hypothetical protein 0.0185 0.1529 0.284
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0033 0.0194 0.0244
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0069 0.0105
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0033 0.0194 0.0488
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0033 0.0194 0.0501
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.035 0.2981 0.5536
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.035 0.2981 0.2981
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0088 0.0088
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.2166 0.4022
Echinococcus granulosus bloom syndrome protein 0.0027 0.0138 0.0207
Echinococcus multilocularis microtubule associated protein 2 0.0766 0.6642 0.8753
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0033 0.0194 0.0488
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0125 0.0999 0.312
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0069 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-40 0.035 0.2981 0.5536
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0165 0.1355 0.204
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0913 0.1447
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.035 0.2981 0.3929
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0069 0.0092
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.0913 0.1064
Trichomonas vaginalis glutathione reductase, putative 0.0125 0.0999 0.1587
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0081 0.0122
Echinococcus granulosus Nuclear hormone receptor HR96 0.0165 0.1355 0.204
Plasmodium falciparum importin beta, putative 0.0031 0.0177 0.0576
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0104 0.0142
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0033 0.0194 0.036
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0033 0.0194 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0194 0.0488
Echinococcus multilocularis geminin 0.0354 0.3016 0.3975
Mycobacterium ulcerans glutamate synthase subunit beta 0.0033 0.0194 0.0244
Brugia malayi PXA domain containing protein 0.0019 0.0069 0.0129
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0227 0.074
Onchocerca volvulus 0.0089 0.0689 0.0833
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0033 0.0194 0.0244
Echinococcus granulosus importin subunit beta 1 0.0031 0.0177 0.0266
Plasmodium vivax glutathione reductase, putative 0.0359 0.3065 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0033 0.0194 0.0271
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0165 0.1355 0.1786
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0359 0.3065 0.3808
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0033 0.0194 0.0244
Brugia malayi Nuclear hormone receptor-like 1 0.0185 0.1529 0.284
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0471 0.0829
Loa Loa (eye worm) hypothetical protein 0.035 0.2981 0.5536
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0129
Echinococcus granulosus microtubule associated protein 2 0.0766 0.6642 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.035 0.2981 0.5536
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0471 0.0471
Mycobacterium ulcerans hypothetical protein 0.0033 0.0194 0.0244
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0129
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0194 0.0271
Brugia malayi hypothetical protein 0.0185 0.1529 0.284
Onchocerca volvulus 0.0115 0.0913 0.1209
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0033 0.0194 0.0271
Brugia malayi ecdysteroid receptor 0.035 0.2981 0.5536
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0069 0.0105
Schistosoma mansoni inositol monophosphatase 0.0037 0.0227 0.0227
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.035 0.2981 0.2981
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2166 0.3496
Loa Loa (eye worm) hypothetical protein 0.0185 0.1529 0.284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0129
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0125 0.0999 0.286
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0328
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0125 0.0999 0.287
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0104 0.0341
Trichomonas vaginalis glutaminase, putative 0.0558 0.4815 0.7829
Brugia malayi hypothetical protein 0.0185 0.1529 0.284
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0165 0.1355 0.1786
Brugia malayi hypothetical protein 0.0165 0.1355 0.2517
Entamoeba histolytica peptidase, C54 family 0.006 0.0428 0.1179
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0033 0.0194 0.0292
Loa Loa (eye worm) hypothetical protein 0.0115 0.0913 0.1696
Schistosoma mansoni Tr4/Tr2 (homologue) 0.035 0.2981 0.2981
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0177 0.0233
Echinococcus granulosus snurportin 1 0.0332 0.2821 0.4247
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0033 0.0194 0.0488
Echinococcus granulosus histone lysine methyltransferase setb 0.0089 0.0689 0.1038
Trypanosoma cruzi polo-like protein kinase, putative 0.04 0.3421 1
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0023 0.0108 0.0353
Loa Loa (eye worm) hypothetical protein 0.0185 0.1529 0.284
Echinococcus granulosus ecdysone induced protein 78C 0.035 0.2981 0.4489
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0177 0.0576
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0069 0.0092
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0033 0.0194 0.0256
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0089 0.0689 0.0909
Brugia malayi RNA, U transporter 1 0.0088 0.068 0.1263
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0033 0.0194 0.0147
Echinococcus granulosus dna polymerase eta 0.002 0.0078 0.0118
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0069 0.0129
Giardia lamblia Thioredoxin reductase 0.0033 0.0194 0.0567
Brugia malayi Pre-SET motif family protein 0.0089 0.0689 0.128
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1388 0.2223
Loa Loa (eye worm) hypothetical protein 0.0115 0.0913 0.1696
Echinococcus granulosus cysteine protease atg4b 0.006 0.0428 0.0645
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0033 0.0194 0.0292
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0194 0.0501
Plasmodium falciparum ferrodoxin reductase-like protein 0.0033 0.0194 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0913 0.2608
Onchocerca volvulus Protein ultraspiracle homolog 0.035 0.2981 0.4686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.035 0.2981 0.5536
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0069 0.0129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0707 0.0931
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0104 0.0224
Echinococcus granulosus tumor protein p63 0.0326 0.2775 0.4178
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0081 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0069 0.0067
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.0913 0.1762
Trichomonas vaginalis glutamate synthase, putative 0.0033 0.0194 0.0271
Plasmodium vivax importin-beta 2, putative 0.0031 0.0177 0.0382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0707 0.1064
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.035 0.2981 0.4489
Entamoeba histolytica peptidase, C54 family 0.0023 0.0108 0.0235
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0227 0.0585
Schistosoma mansoni hypothetical protein 0.0354 0.3016 0.3016
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2166 0.3496
Loa Loa (eye worm) hypothetical protein 0.0122 0.0977 0.1814
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0227 0.0324
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0033 0.0194 0.0488
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0125 0.0999 0.1504
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0033 0.0194 0.0256
Brugia malayi nuclear hormone receptor 0.035 0.2981 0.5536
Brugia malayi hypothetical protein 0.0236 0.1975 0.3668
Echinococcus granulosus nuclear receptor 2DBD gamma 0.035 0.2981 0.4489
Trypanosoma brucei NADH dehydrogenase 0.0033 0.0194 0.0501
Schistosoma mansoni nuclear hormone receptor 0.035 0.2981 0.2981
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.035 0.2981 0.2981
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0289 0.0779
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0707 0.0707
Schistosoma mansoni retinoid-x-receptor (RXR) 0.035 0.2981 0.2981
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0185 0.1529 0.1529
Brugia malayi hypothetical protein 0.0122 0.0977 0.1814
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0081 0.0081
Loa Loa (eye worm) steroid hormone receptor 0.035 0.2981 0.5536
Echinococcus granulosus expressed protein 0.0368 0.314 0.4728
Schistosoma mansoni autophagin-1 (C54 family) 0.006 0.0428 0.0428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0707 0.0931
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0428 0.1179
Loa Loa (eye worm) hypothetical protein 0.035 0.2981 0.5536
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0428 0.1179
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0069 0.0092
Echinococcus multilocularis nuclear receptor nhr 48 0.0165 0.1355 0.1786
Echinococcus multilocularis snurportin 1 0.0332 0.2821 0.3717
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0913 0.0913
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.035 0.2981 0.5536
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0078 0.016
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0069 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.016
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.035 0.2981 0.2981
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0033 0.0194 0.0633
Giardia lamblia Kinase, PLK 0.04 0.3421 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.1645 0.2643
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0138 0.0179
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0069 0.0105
Mycobacterium leprae conserved hypothetical protein 0.0115 0.0913 0.0932
Trichomonas vaginalis CAMK family protein kinase 0.04 0.3421 0.5549
Plasmodium falciparum thioredoxin reductase 0.0359 0.3065 1
Loa Loa (eye worm) nuclear hormone receptor 0.0165 0.1355 0.2517
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0069 0.0129
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0165 0.1355 0.1786
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0033 0.0194 0.0271
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0911 0.792 1
Mycobacterium leprae Probable lipase LipE 0.0115 0.0913 0.0932
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0069 0.0129
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0227 0.0585
Mycobacterium ulcerans monoxygenase 0.0033 0.0194 0.0244
Mycobacterium ulcerans ferredoxin reductase 0.0033 0.0194 0.0244
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0165 0.1355 0.1952
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0078 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1388 0.2223
Plasmodium falciparum thioredoxin reductase 0.0125 0.0999 0.3259
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0078 0.0146
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0227 0.0324
Plasmodium falciparum cysteine protease ATG4, putative 0.0023 0.0108 0.0353
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.035 0.2981 0.4489
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0069 0.0129
Loa Loa (eye worm) hypothetical protein 0.035 0.2981 0.5536
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0471 0.0709
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0078 0.0147
Mycobacterium tuberculosis Putative ferredoxin reductase 0.082 0.7115 0.8974
Brugia malayi Nuclear hormone receptor E75 0.0165 0.1355 0.2517
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0689 0.0909
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0069 0.0067
Mycobacterium tuberculosis Conserved protein 0.0115 0.0913 0.1064
Trichomonas vaginalis CAMK family protein kinase 0.04 0.3421 0.5549
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0069 0.0092
Echinococcus granulosus serine:threonine protein kinase PLK1 0.04 0.3421 0.515
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0913 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-1 0.035 0.2981 0.5536
Loa Loa (eye worm) hypothetical protein 0.035 0.2981 0.5536
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0033 0.0194 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2166 0.3496
Trichomonas vaginalis glutamate synthase, putative 0.0033 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Entamoeba histolytica hypothetical protein 0.0019 0.0069 0.0121
Onchocerca volvulus 0.0165 0.1355 0.1952
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.0913 0.1203
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0289 0.0767
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0033 0.0194 0.0271
Trichomonas vaginalis set domain proteins, putative 0.0709 0.6142 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0033 0.0194 0.0488
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0146
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0227 0.0313
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0078 0.0147
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.0913 0.1064
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0108 0.0235
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0125 0.0999 0.312
Brugia malayi Nuclear hormone receptor E75 0.0165 0.1355 0.2517
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.1388 0.2007
Loa Loa (eye worm) hypothetical protein 0.0165 0.1355 0.2517
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0069 0.0129
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0138 0.0181
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.006 0.0195
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.04 0.3421 0.6352
Brugia malayi nuclear hormone receptor family member nhr-6 0.0165 0.1355 0.2517
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0104 0.0341
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0033 0.0194 0.0488
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0471 0.0829
Trichomonas vaginalis ran, putative 0.0023 0.0104 0.0124
Entamoeba histolytica peptidase, C54 family 0.0023 0.0108 0.0235
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0913 0.2835
Brugia malayi glutamate synthase 0.0033 0.0194 0.036
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0165 0.1355 0.2517
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0125 0.0999 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0999 0.286
Onchocerca volvulus 0.0048 0.0326 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0689 0.0689
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.035 0.2981 0.3929
Loa Loa (eye worm) thioredoxin reductase 0.0359 0.3065 0.5692
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0194 0.0271
Giardia lamblia DINP protein human, muc B family 0.002 0.0078 0.0229
Echinococcus granulosus geminin 0.0354 0.3016 0.4541
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0999 0.286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.035 0.2981 0.5536
Mycobacterium ulcerans dehydrogenase 0.0033 0.0194 0.0244
Schistosoma mansoni DNA polymerase eta 0.002 0.0078 0.0078
Brugia malayi ecdysone receptor 0.0165 0.1355 0.2517
Schistosoma mansoni nuclear receptor 0.0165 0.1355 0.1355
Brugia malayi Nuclear hormone receptor family member nhr-19 0.035 0.2981 0.5536

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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