Detailed information for compound 1071827

Basic information

Technical information
  • TDR Targets ID: 1071827
  • Name: N-(2-methylpropyl)-N-[(3S)-pyrrolidin-3-yl]na phthalene-2-carboxamide
  • MW: 296.407 | Formula: C19H24N2O
  • H donors: 1 H acceptors: 1 LogP: 3.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CN(C(=O)c1ccc2c(c1)cccc2)[C@@H]1CNCC1)C
  • InChi: 1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m0/s1
  • InChiKey: CEUJKSVEPJAVKD-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-isobutyl-N-[(3S)-pyrrolidin-3-yl]naphthalene-2-carboxamide
  • N-isobutyl-N-[(3S)-3-pyrrolidinyl]-2-naphthalenecarboxamide
  • N-isobutyl-N-[(3S)-pyrrolidin-3-yl]-2-naphthamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.038 0.1408
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0186 0.0688
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0951 0.2663 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0009
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0023 0.0096
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.014 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Brugia malayi ecdysteroid receptor 0.0021 0.0025 0.0092
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.002 0.002
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.042 0.1157 0.4315
Brugia malayi intermediate filament protein 0.0029 0.0047 0.0176
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0063 0.0302
Loa Loa (eye worm) hypothetical protein 0.01 0.0248 0.093
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Entamoeba histolytica hypothetical protein 0.0109 0.0276 0.5655
Loa Loa (eye worm) hypothetical protein 0.0238 0.0639 0.2399
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0951 0.2663 1
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0045 0.0093 0.0237
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0012 0.0012
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0315 0.0858 0.0858
Loa Loa (eye worm) hypothetical protein 0.0034 0.0062 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0145
Schistosoma mansoni DNA polymerase eta 0.002 0.0023 0.0023
Schistosoma mansoni smad 0.0019 0.002 0.002
Brugia malayi PAS domain containing protein 0.0051 0.0109 0.0411
Brugia malayi Phosphoglycerate kinase 0.0066 0.0152 0.0569
Echinococcus granulosus pyruvate kinase 0.0034 0.0063 0.0063
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0056 0.02
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0113 0.0113
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0398
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0003 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0067 0.024
Plasmodium falciparum glutathione reductase 0.005 0.0107 0.035
Mycobacterium leprae conserved hypothetical protein 0.0185 0.0489 0.1829
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0025 0.0092
Trypanosoma brucei trypanothione reductase 0.005 0.0107 0.0383
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0248 0.0248
Mycobacterium ulcerans hypothetical protein 0.0163 0.0426 0.1555
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0107 0.0107
Echinococcus granulosus geminin 0.0179 0.0474 0.0474
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0016
Brugia malayi Inositol-1 0.0036 0.0067 0.025
Brugia malayi Thioredoxin reductase 0.005 0.0107 0.0403
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0106 0.0106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0025 0.0092
Schistosoma mansoni Smad4 0.0043 0.0087 0.0087
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0064 0.0228
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0481 0.0481
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0186 0.0688
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0185 0.0489 0.144
Loa Loa (eye worm) hypothetical protein 0.0179 0.0473 0.1773
Echinococcus multilocularis Aminotransferase class III 0.0045 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Brugia malayi RNA binding protein 0.0126 0.0324 0.1217
Trypanosoma brucei hypothetical protein, conserved 0.0185 0.0489 0.1821
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0025 0.0092
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0025 0.0025
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0186 0.0186
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0068
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0089 0.0313
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0045 0.0093 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Echinococcus multilocularis Smad4 0.0043 0.0087 0.0087
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0107 0.035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0212 0.0212
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0044 0.011
Brugia malayi GMP reductase 0.042 0.1157 0.4346
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.0228 0.1126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0007 0.0015
Echinococcus granulosus transient receptor potential gamma protein 0.0103 0.0257 0.0257
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0025 0.0091
Echinococcus multilocularis dna polymerase kappa 0.002 0.0023 0.0023
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0063 0.0217
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0308
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0016
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.002 0.0074
Onchocerca volvulus 0.0028 0.0044 0.0205
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0019
Onchocerca volvulus 0.0185 0.0489 0.2434
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0106 0.0106
Brugia malayi hypothetical protein 0.0109 0.0276 0.1034
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0045 0.0093 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0181
Echinococcus granulosus peptidase Clp S14 family 0.0156 0.0407 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0025 0.0092
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0398
Loa Loa (eye worm) hypothetical protein 0.0078 0.0186 0.0697
Schistosoma mansoni hypothetical protein 0.01 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.0248 0.0248
Loa Loa (eye worm) nuclear factor I 0.0024 0.0033 0.0122
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0007 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0025 0.0025
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0025 0.0092
Brugia malayi MH2 domain containing protein 0.063 0.1752 0.6578
Echinococcus granulosus ornithine aminotransferase 0.0045 0.0093 0.0093
Onchocerca volvulus 0.0029 0.0048 0.0225
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0051 0.0139
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0316
Brugia malayi Transient-receptor-potential like protein 0.004 0.0079 0.0297
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0063 0.0184
Schistosoma mansoni pyruvate kinase 0.0018 0.0016 0.0016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.014 0.014
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0152 0.0559
Echinococcus granulosus dna polymerase kappa 0.002 0.0023 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0044 0.0546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0481 0.0481
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0015 0.0044
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0345
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0345
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.014 0.014
Schistosoma mansoni lamin 0.0029 0.0047 0.0047
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0015 0.0059
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0067 0.0319
Leishmania major DNA polymerase eta, putative 0.002 0.0023 0.0077
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0044 0.0154
Echinococcus granulosus cpg binding protein 0.0031 0.0053 0.0053
Brugia malayi hypothetical protein 0.017 0.0449 0.1684
Echinococcus granulosus phosphoglycerate kinase 1 0.0179 0.0473 0.0473
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis importin subunit beta 1 0.003 0.0051 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.0481 0.1808
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0063 0.0302
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0063 0.0237
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0951 0.2663 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0186 0.0186
Leishmania major hypothetical protein, conserved 0.0027 0.0042 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0048 0.0226
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0025 0.0092
Brugia malayi MH1 domain containing protein 0.0024 0.0033 0.0123
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0125 0.0334
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0016 0.0004
Schistosoma mansoni pyruvate kinase 0.0034 0.0063 0.0063
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0051
Brugia malayi nuclear hormone receptor 0.0021 0.0025 0.0092
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.0097
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0324 0.1216
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0029 0.0029
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0179 0.0473 0.235
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0067 0.024
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0089 0.0322
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0007 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Schistosoma mansoni hypothetical protein 0.01 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Schistosoma mansoni transient receptor potential channel 0.0069 0.0161 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Brugia malayi Pre-SET motif family protein 0.0091 0.0224 0.084
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0125 0.0416
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0056 0.0126
Mycobacterium tuberculosis Probable reductase 0.0114 0.0289 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0025 0.0025
Trypanosoma brucei phosphoglycerate kinase, putative 0.0066 0.0152 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0089 0.0322
Brugia malayi MH1 domain containing protein 0.0043 0.0087 0.0327
Schistosoma mansoni importin beta-1 0.003 0.0051 0.0051
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0078 0.0186 0.3739
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.014 0.0472
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0186 0.0186
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0045 0.0093 0.0237
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0017 0.0042
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Schistosoma mansoni smad1 5 8 and 0.0043 0.0087 0.0087
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0025 0.0108
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0087 0.0087
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0106 0.0106
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0063 0.0302
Mycobacterium ulcerans L-lysine aminotransferase 0.0045 0.0093 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0025 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0044 0.0154
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0042 0.0148
Mycobacterium tuberculosis Probable lipase LipD 0.0185 0.0489 0.144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.0481 0.1807
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0025 0.0092
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0089 0.0089
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0179 0.0473 0.1766
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0025 0.0025
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0089 0.0332
Loa Loa (eye worm) GMP reductase 0.042 0.1157 0.4345
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0067 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0089 0.0429
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0161 0.0161
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.024 0.024
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.2358
Plasmodium vivax phosphoglycerate kinase, putative 0.0179 0.0473 0.1729
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0025 0.0025
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0125 0.0125
Schistosoma mansoni cpg binding protein 0.0031 0.0053 0.0053
Echinococcus granulosus importin subunit beta 1 0.003 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0015 0.0059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0089 0.0333
Echinococcus granulosus Aminotransferase class III 0.0045 0.0093 0.0093
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0206 0.4181
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0035 0.0161
Trichomonas vaginalis esterase, putative 0.0185 0.0489 0.2434
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0029 0.0053
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0087 0.0087
Echinococcus granulosus pyruvate kinase 0.0034 0.0063 0.0063
Schistosoma mansoni cpg binding protein 0.0029 0.0048 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0224 0.0224
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0185 0.0489 0.144
Echinococcus multilocularis phosphoglycerate kinase 1 0.0179 0.0473 0.0473
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0048 0.0178
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0042 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0125 0.0469
Plasmodium falciparum ornithine aminotransferase 0.0045 0.0093 0.0295
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0044 0.011
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0016 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0021 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0042 0.0105
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0088
Brugia malayi latrophilin 2 splice variant baaae 0.0215 0.0576 0.2163
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0107 0.0281
Toxoplasma gondii hypothetical protein 0.0082 0.0198 0.0691
Giardia lamblia Pyruvate kinase 0.0034 0.0063 0.1061
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.042 0.1157 0.4346
Brugia malayi follicle stimulating hormone receptor 0.0723 0.2015 0.7565
Brugia malayi Probable ClpP-like protease 0.0238 0.0639 0.24
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0025 0.0092
Echinococcus multilocularis dna polymerase eta 0.002 0.0023 0.0023
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0019
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0025 0.0092
Echinococcus granulosus tumor protein p63 0.1032 0.2893 0.2893
Trypanosoma brucei unspecified product 0.002 0.0023 0.0068
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0045 0.0093 0.0337
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0023 0.0068
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0087 0.0087
Mycobacterium tuberculosis Conserved protein 0.0185 0.0489 0.144
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0063 0.0227
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0276 0.0276
Plasmodium vivax SET domain protein, putative 0.0091 0.0224 0.0789
Brugia malayi beta-lactamase family protein 0.0185 0.0489 0.1837
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0034 0.0125
Schistosoma mansoni ran 0.0022 0.0029 0.0029
Echinococcus granulosus smad 0.0043 0.0087 0.0087
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0003 0.0009
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0087 0.0087
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0025 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0023 0.0086
Chlamydia trachomatis pyruvate kinase 0.0034 0.0063 0.0948
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.014 0.0472
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0324 0.0324
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0248 0.0248
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0067 0.0319
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0024 0.0069
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0531 0.1471 0.552
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0224 0.0224
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0007 0.0007
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0045 0.0093 0.0295
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0007 0.0025
Trypanosoma brucei GMP reductase 0.0951 0.2663 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.002 0.0085
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0009 0.0033
Schistosoma mansoni phosphoglycerate kinase 0.0179 0.0473 0.0473
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0103 0.0257 0.0965
Trypanosoma brucei phosphoglycerate kinase 0.0179 0.0473 0.1758
Onchocerca volvulus 0.0038 0.0072 0.0346
Brugia malayi RNA, U transporter 1 0.0086 0.021 0.0788
Schistosoma mansoni cellular tumor antigen P53 0.0151 0.0394 0.0394
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0048 0.0101 0.0379
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0106 0.1621
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.0228 0.0806
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0489 0.2434
Leishmania major protein kinase, putative 0.0019 0.002 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0489 0.1829
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0107 0.0107
Plasmodium falciparum phosphoglycerate kinase 0.0179 0.0473 0.1729
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0017
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Schistosoma mansoni hypothetical protein 0.0414 0.1138 0.1138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0045 0.0093 0.0295
Plasmodium falciparum transporter, putative 0.005 0.0106 0.0345
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0108
Giardia lamblia Pyruvate kinase 0.0018 0.0016 0.0022
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0109 0.0276 0.5655
Plasmodium vivax amine transporter, putative 0.005 0.0106 0.0345
Echinococcus multilocularis musashi 0.0029 0.0047 0.0047
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0023 0.0077
Brugia malayi acetyltransferase, GNAT family protein 0.0315 0.0858 0.3222
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0089 0.0323
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0106 0.0106
Brugia malayi TAR-binding protein 0.0126 0.0324 0.1217
Echinococcus multilocularis transient receptor potential gamma protein 0.0103 0.0257 0.0257
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0186 0.0186
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0044 0.0154
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0175
Loa Loa (eye worm) hypothetical protein 0.0292 0.0794 0.2979
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0106 0.0106
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0951 0.2663 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0125 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0224 0.0224
Brugia malayi CXXC zinc finger family protein 0.0029 0.0048 0.0179
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0045 0.0093 0.0237
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0161 0.0161
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0063 0.0227
Echinococcus granulosus lamin dm0 0.0029 0.0047 0.0047
Leishmania major pyruvate kinase 0.0034 0.0063 0.0227
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0107 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0025 0.0092
Trichomonas vaginalis set domain proteins, putative 0.0718 0.2002 1
Mycobacterium tuberculosis Probable lipase LipE 0.0185 0.0489 0.144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0044 0.011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0324 0.1216
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0951 0.2663 0.2663
Echinococcus granulosus dna polymerase eta 0.002 0.0023 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0489 0.2434
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0021 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0042 0.0105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0315 0.0859 0.3225
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0106 0.0106
Leishmania major hypothetical protein, conserved 0.0185 0.0489 0.1829
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0153 0.0522
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0044 0.0154
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.0489 0.0489
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.0033
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0206 0.4124
Echinococcus multilocularis lamin dm0 0.0029 0.0047 0.0047
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0016 0.0004
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0161 0.0161
Entamoeba histolytica phosphoglycerate kinase, putative 0.0179 0.0473 1
Schistosoma mansoni phosphoglycerate kinase 0.0179 0.0473 0.0473
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0025 0.0091
Schistosoma mansoni hypothetical protein 0.0179 0.0474 0.0474
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0289 0.0832
Schistosoma mansoni lamin 0.0029 0.0047 0.0047
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.014 0.0379
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0161 0.0161
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0079 0.0189 0.07
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0012 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0481 0.0481
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0047 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0025 0.0091
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0106 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0951 0.2663 1
Schistosoma mansoni cpg binding protein 0.0031 0.0053 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0169
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0012 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0481 0.0481
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0238 0.0639 0.2358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0063 0.0237
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.0248 0.0248
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0325 0.1211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0178
Loa Loa (eye worm) RNA binding protein 0.0126 0.0324 0.1216
Brugia malayi beta-lactamase 0.0185 0.0489 0.1837
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.0097
Echinococcus multilocularis beta LACTamase domain containing family member 0.0185 0.0489 0.0489
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0035 0.0161
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.0088
Plasmodium falciparum thioredoxin reductase 0.005 0.0107 0.035
Schistosoma mansoni hypothetical protein 0.01 0.0248 0.0248
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0051 0.0173
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0296
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0045 0.0093 0.0295
Loa Loa (eye worm) MH2 domain-containing protein 0.063 0.1752 0.6577
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0951 0.2663 1
Loa Loa (eye worm) Smad1 0.0043 0.0087 0.0326
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0063 0.0147
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0185 0.0489 0.1793
Giardia lamblia DINP protein human, muc B family 0.002 0.0023 0.0192
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0021 0.0019
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0106 0.0106
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0015
Brugia malayi Smad1 0.0043 0.0087 0.0327
Echinococcus granulosus single minded 2 0.0042 0.0084 0.0084
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0315 0.086 0.2564
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0198 0.0691
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.014 0.0472
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.0228 0.0806
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0343 0.0343
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0125 0.0458
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0063 0.0236
Echinococcus granulosus GPCR family 2 0.01 0.0248 0.0248
Echinococcus multilocularis pyruvate kinase 0.0034 0.0063 0.0063
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0024 0.0035
Schistosoma mansoni ran 0.0022 0.0029 0.0029
Leishmania major DNA polymerase kappa, putative 0.002 0.0023 0.0077
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0248 0.093
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0179 0.0473 0.1389
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.1264 0.1264
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.002 0.0073
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.042 0.1157 0.434
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0044 0.011
Brugia malayi MH1 domain containing protein 0.0024 0.0033 0.0123
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0238 0.0639 0.2391
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0841 0.3149
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0025 0.0025
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.2358
Mycobacterium ulcerans hypothetical protein 0.0315 0.086 0.3192
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0034 0.0322
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0044 0.011
Trypanosoma cruzi GMP reductase 0.0951 0.2663 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.0489 0.2434
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0084 0.0403
Onchocerca volvulus 0.0185 0.0489 0.2434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0181
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0023 0.0027
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0029 0.0053
Plasmodium vivax importin-beta 2, putative 0.003 0.0051 0.0139
Loa Loa (eye worm) hypothetical protein 0.0063 0.0144 0.0538
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0089 0.0313
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0081
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0718 0.2002 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0325 0.0941
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0007 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0023 0.0077
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0224 0.0789
Echinococcus multilocularis cpg binding protein 0.0031 0.0053 0.0053
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0066 0.0152 0.0559
Echinococcus multilocularis tumor protein p63 0.1032 0.2893 0.2893
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0079 0.0079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.118 0.3313 1
Echinococcus granulosus lamin 0.0029 0.0047 0.0047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0325 0.0941
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0009 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0146
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0035 0.0161
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Brugia malayi Phosphoglycerate kinase 0.0179 0.0473 0.1774
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0035
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0063 0.0302
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0289 0.1075
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0044 0.0154
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0109 0.0276 0.5655
Brugia malayi MH2 domain containing protein 0.0043 0.0087 0.0327
Loa Loa (eye worm) glutathione reductase 0.005 0.0107 0.0401
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0042 0.0148
Schistosoma mansoni hypothetical protein 0.01 0.0248 0.0248
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.002 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.015 0.015
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0045 0.0093 0.0337
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0061
Brugia malayi Latrophilin receptor protein 2 0.01 0.0248 0.0931
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0125 0.0125
Mycobacterium tuberculosis Conserved protein 0.0185 0.0489 0.144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0125
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0198 0.0691
Onchocerca volvulus 0.005 0.0106 0.0516
Plasmodium vivax hypothetical protein, conserved 0.005 0.0106 0.0345
Schistosoma mansoni single-minded 0.0051 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.0323 0.0883 0.0883
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0057 0.0161
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0025 0.0091
Loa Loa (eye worm) IMP dehydrogenase 1 0.0951 0.2663 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0106 0.0106
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0106 0.0398
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0403 0.0403
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0012 0.0012
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0106 0.0106
Plasmodium falciparum pyruvate kinase 0.0034 0.0063 0.0184
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0025 0.0025
Schistosoma mansoni Smad4 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0292 0.0794 0.2979
Brugia malayi beta-lactamase family protein 0.0185 0.0489 0.1837
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0178
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0106 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0051 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0007 0.0015
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0179 0.0473 0.1766
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0089 0.0323
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0163
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0185 0.0489 0.1793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0025 0.0091
Loa Loa (eye worm) hypothetical protein 0.0091 0.0224 0.0839
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0292 0.0794 0.2979
Schistosoma mansoni coup transcription factor 0.0021 0.0025 0.0025
Mycobacterium ulcerans hypothetical protein 0.0185 0.0489 0.1793
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0023 0.0027
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0025 0.0025
Leishmania major guanosine monophosphate reductase 0.0951 0.2663 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.014 0.0514
Chlamydia trachomatis phosphoglycerate kinase 0.0179 0.0473 0.7383
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0025 0.0025
Onchocerca volvulus 0.005 0.0106 0.0516
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0063 0.0302
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0087 0.0087
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0397
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.0411 0.1542
Echinococcus multilocularis smad 0.0043 0.0087 0.0087
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.0228 0.0228
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0063 0.0184
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0198 0.2349
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Echinococcus granulosus beta LACTamase domain containing family member 0.0185 0.0489 0.0489
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0044 0.0088
Onchocerca volvulus Putative GMP reductase 0.042 0.1157 0.5775
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0186 0.0915
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Mycobacterium tuberculosis Probable esterase LipL 0.0185 0.0489 0.144
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0106 0.0106
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0079 0.0189 0.07
Brugia malayi hypoxia-induced factor 1 0.0157 0.0411 0.1544
Toxoplasma gondii thioredoxin reductase 0.005 0.0107 0.035
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0035 0.0121
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0841 0.3149
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0089 0.1536
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0015 0.0035
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0007 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0044 0.011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0426 0.1249
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0015 0.0044
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0067 0.023
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0106 0.0106
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0019 0.0017
Brugia malayi nuclear receptor NHR-88 0.0021 0.0025 0.0092
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0067 0.105
Entamoeba histolytica hypothetical protein 0.0109 0.0276 0.5655
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0067 0.0196
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0186 0.0698
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0238 0.0639 0.0639
Brugia malayi glutathione reductase 0.005 0.0107 0.0403
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0044 0.0164
Trypanosoma brucei phosphoglycerate kinase 0.0066 0.0152 0.055
Loa Loa (eye worm) inositol-1 0.0036 0.0067 0.0249
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0025 0.0091
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0113 0.0113
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0025 0.0092
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0951 0.2663 1
Mycobacterium ulcerans hypothetical protein 0.0028 0.0044 0.011
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0087 0.0326
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0003 0.0003
Schistosoma mansoni intermediate filament proteins 0.0029 0.0047 0.0047
Schistosoma mansoni smad 0.0043 0.0087 0.0087
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0106 0.0106
Schistosoma mansoni smad1 5 8 and 0.0043 0.0087 0.0087
Plasmodium falciparum amino acid transporter, putative 0.005 0.0106 0.0345
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.014 0.0472
Schistosoma mansoni hypothetical protein 0.0109 0.0276 0.0276
Echinococcus multilocularis snurportin 1 0.0323 0.0883 0.0883
Treponema pallidum phosphoglycerate kinase 0.0179 0.0473 0.588
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0325 0.0941
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0044 0.0546
Mycobacterium tuberculosis Probable hydrolase 0.0185 0.0489 0.144
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0025 0.0092
Leishmania major GTP-binding protein, putative 0.0022 0.0029 0.0097
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0047 0.0175
Plasmodium vivax glutathione reductase, putative 0.005 0.0107 0.035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0045 0.0093 0.1411
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0023
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0315 0.0858 0.0858
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0042
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0206 0.0723
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.0841 0.3149
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.002 0.002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0023 0.0103
Brugia malayi Pre-SET motif family protein 0.0631 0.1755 0.659
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0053
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0106 0.0106
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0238 0.0639 0.2358
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0042 0.0105
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0289 0.0832
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0016
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0397
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0007 0.0005
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0106 0.0106
Loa Loa (eye worm) transcription factor SMAD2 0.063 0.1752 0.6577
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.0489 0.0489
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0723 0.2015 0.7565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0156 0.0407 0.1519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0089 0.0429
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0015 0.0055
Entamoeba histolytica Ran family GTPase 0.0022 0.0029 0.0213
Leishmania major trypanothione reductase 0.005 0.0107 0.0392
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0007 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0481 0.0481
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0024 0.0028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0185 0.0489 0.144
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0019
Toxoplasma gondii exonuclease III APE 0.0019 0.0019 0.0017
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0156 0.0407 0.119
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0186 0.0186
Brugia malayi MH1 domain containing protein 0.0043 0.0087 0.0327
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0163
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0186 0.0186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0019 0.0097
Entamoeba histolytica hypothetical protein 0.0025 0.0035 0.0355
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.2358
Mycobacterium tuberculosis Probable aminotransferase 0.0315 0.086 0.2564
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0045 0.0093 0.0295
Leishmania major phosphoglycerate kinase C, glycosomal 0.0179 0.0473 0.1766
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0089 0.0089
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0186 0.0186
Echinococcus granulosus neuropeptide s receptor 0.0458 0.1264 0.1264
Leishmania major pyruvate kinase 0.0034 0.0063 0.0227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0248 0.0931
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0179 0.0473 0.1729
Schistosoma mansoni inositol monophosphatase 0.0036 0.0067 0.0067
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.0101 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0481 0.0481
Onchocerca volvulus 0.0021 0.0025 0.0108
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0025 0.0025
Schistosoma mansoni transient receptor potential channel 0.0103 0.0257 0.0257
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.0794 0.0794
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0015 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0025 0.0025
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0045 0.0093 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0044 0.011
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0122
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0045 0.0093 0.0237
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0403 0.0403
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0951 0.2663 1
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0489 0.1829
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.038 0.1416
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0951 0.2663 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0025 0.0025
Brugia malayi hypothetical protein 0.0018 0.0015 0.0057
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0186 0.0679
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.0093 0.0093
Trypanosoma cruzi GMP reductase 0.0951 0.2663 1
Giardia lamblia Phosphoglycerate kinase 0.0179 0.0473 1
Mycobacterium ulcerans beta-lactamase 0.0185 0.0489 0.1793
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.024 0.024
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.1264 0.1264
Brugia malayi hypothetical protein 0.0027 0.0042 0.0159
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0951 0.2663 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0063 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0019 0.0057
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0029 0.0029
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0186 0.3678
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0019 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0146
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0185 0.0489 0.1836
Schistosoma mansoni transient receptor potential channel 4 0.0103 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Onchocerca volvulus 0.0151 0.0395 0.196
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0035
Loa Loa (eye worm) acetyltransferase 0.0315 0.0858 0.3221
Onchocerca volvulus 0.0185 0.0489 0.2434
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0107 0.0392
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0025 0.0108
Toxoplasma gondii IMP dehydrogenas 0.0951 0.2663 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0079 0.0079
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0019 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0481 0.0481
Brugia malayi steroid hormone receptor 0.0021 0.0025 0.0092
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0072 0.027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0019 0.0061
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0215 0.0576 0.2162
Brugia malayi MH2 domain containing protein 0.0043 0.0087 0.0327
Onchocerca volvulus 0.0151 0.0394 0.1956
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.0101 0.0101
Echinococcus granulosus dnaJ subfamily B 0.0414 0.1138 0.1138
Echinococcus multilocularis GPCR, family 2 0.01 0.0248 0.0248
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.2358
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0315 0.086 0.3192
Echinococcus multilocularis geminin 0.0179 0.0474 0.0474
Loa Loa (eye worm) serotonin transporter b 0.0292 0.0794 0.2979
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0398
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0072 0.0217
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0048 0.0101 0.038
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0951 0.2663 0.8031
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0224 0.0224
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0531 0.1471 0.4417
Brugia malayi hypothetical protein 0.0151 0.0395 0.1482
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.0794 0.2979
Schistosoma mansoni peptidase Clp (S14 family) 0.0238 0.0639 0.0639
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0951 0.2663 0.2663
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0044 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.1138 0.1138
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Echinococcus multilocularis serotonin transporter 0.0292 0.0794 0.0794
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0025 0.0108
Onchocerca volvulus 0.0029 0.0047 0.0221
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0025 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.002 0.0073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0084 0.0403
Mycobacterium leprae Probable lipase LipE 0.0185 0.0489 0.1829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0146
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0106 0.0106
Trichomonas vaginalis ran, putative 0.0022 0.0029 0.0129
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0045 0.0093 0.0093
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0289 0.0832
Leishmania major importin beta-1 subunit, putative 0.0025 0.0035 0.0121
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0082 0.0198 0.0732
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0186 0.0915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0046 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.0841 0.3142
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0064 0.0228
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0044 0.0164
Loa Loa (eye worm) hypothetical protein 0.0034 0.0063 0.0236
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0179 0.0473 0.1729
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0024 0.0332
Echinococcus granulosus histone acetyltransferase KAT2B 0.0306 0.0833 0.0833
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0025 0.0025
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.0794 1
Toxoplasma gondii hypothetical protein 0.005 0.0106 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0025 0.0092
Trypanosoma brucei phosphoglycerate kinase 0.0179 0.0473 0.1758
Echinococcus granulosus tar DNA binding protein 0.0126 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0151 0.0395 0.1481
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0003 0.0003
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0951 0.2663 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0158
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0079 0.0189 0.07
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0025 0.0025
Mycobacterium ulcerans esterase/lipase LipP 0.0185 0.0489 0.1793
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0045 0.0093 0.0337
Plasmodium vivax ornithine aminotransferase, putative 0.0045 0.0093 0.0295
Schistosoma mansoni hypothetical protein 0.0215 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0089 0.0323
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0015 0.0044
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0315 0.086 0.4288
Schistosoma mansoni transient receptor potential channel 0.0069 0.0161 0.0161
Schistosoma mansoni pyruvate kinase 0.0034 0.0063 0.0063
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.014 0.014
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.8018
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.038 0.1416
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0063 0.0217
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0063 0.0236
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0042 0.0105
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0067 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0025 0.0091
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0047 0.0176
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0179 0.0473 0.1766
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0044 0.0546
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0072 0.0072
Mycobacterium ulcerans lipase LipD 0.0185 0.0489 0.1793
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0315 0.0859 0.3224
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0951 0.2663 0.2663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0071 0.0339
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0276 0.0276
Echinococcus multilocularis lamin 0.0029 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0025 0.0092
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0324 0.1217
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0289 0.0832
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0067 0.0067
Onchocerca volvulus 0.005 0.0106 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0089 0.0429
Leishmania major inosine-5-monophosphate dehydrogenase 0.0951 0.2663 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0019 0.0017
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0315 0.086 0.3222
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.0071
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0063 0.0184
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.002 0.002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0224 0.0224
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0238 0.0639 0.2358
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0185 0.0489 0.1837
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Mycobacterium ulcerans phosphoglycerate kinase 0.0179 0.0473 0.1729
Giardia lamblia GTOR 0.0043 0.0089 0.1618
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0152 0.0559
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0086
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0115 0.0423
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.0192
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0089 0.0089
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0224 0.0224
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0067 0.0319
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0089 0.0323
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0015 0.0035
Schistosoma mansoni hypothetical protein 0.0179 0.0474 0.0474
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0025 0.0092
Mycobacterium tuberculosis Conserved protein 0.0185 0.0489 0.144
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.042 0.1157 0.4346
Brugia malayi hypothetical protein 0.005 0.0106 0.0398
Echinococcus multilocularis peptidase Clp (S14 family) 0.0156 0.0407 0.0407
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0089 0.1536
Loa Loa (eye worm) hypothetical protein 0.0315 0.0859 0.3224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0021 0.0019
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0015 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.0883 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0145
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0089 0.0313
Schistosoma mansoni hypothetical protein 0.0133 0.0343 0.0343
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0114 0.0427
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Loa Loa (eye worm) beta-lactamase 0.0185 0.0489 0.1836
Onchocerca volvulus 0.0091 0.0224 0.1104
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0063 0.0236
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0023 0.0023
Toxoplasma gondii hypothetical protein 0.005 0.0107 0.0347
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.0794 0.0794
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0289 0.0832
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0125 0.0125
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0276 0.0276
Echinococcus multilocularis pyruvate kinase 0.0027 0.0043 0.0043
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0067 0.0196
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0002 0.0006
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0186 0.0688
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0631 0.1755 0.6589
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0179 0.0473 0.235
Brugia malayi MH2 domain containing protein 0.0019 0.002 0.0074
Mycobacterium ulcerans acetylornithine aminotransferase 0.0045 0.0093 0.0295
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0238 0.0639 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0025 0.0092
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0156 0.0407 0.119
Echinococcus granulosus snurportin 1 0.0323 0.0883 0.0883
Plasmodium falciparum importin beta, putative 0.003 0.0051 0.0139
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.1264 0.1264
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0064 0.0219
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0025 0.0025
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0145
Echinococcus granulosus serotonin transporter 0.0292 0.0794 0.0794
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.0228 0.0806
Loa Loa (eye worm) hypothetical protein 0.0151 0.0394 0.1478
Onchocerca volvulus 0.0029 0.0047 0.0221
Loa Loa (eye worm) hypothetical protein 0.017 0.0449 0.1683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Toxoplasma gondii ABC1 family protein 0.0185 0.0489 0.1793
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0087 0.0326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0345
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.0403 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0186 0.0915
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0015
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0106 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Schistosoma mansoni inositol monophosphatase 0.0036 0.0067 0.0067
Toxoplasma gondii hypothetical protein 0.005 0.0106 0.0345
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0315 0.0859 0.3225
Onchocerca volvulus 0.0292 0.0794 0.3955
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0106 0.0106
Echinococcus granulosus intermediate filament protein 0.0029 0.0047 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0044 0.0088
Schistosoma mansoni Smad4 0.0019 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.0794 0.2979
Brugia malayi Importin beta-1 subunit 0.003 0.0051 0.0193
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.0794 0.2979
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0016
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0023
Leishmania major phosphoglycerate kinase B, cytosolic 0.0179 0.0473 0.1766
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0181
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0016
Echinococcus granulosus Smad4 0.0043 0.0087 0.0087
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0023 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0068
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0017
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0179 0.0473 0.1729
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Schistosoma mansoni smad1 5 8 and 0.0043 0.0087 0.0087
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.0228 0.1126
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0106 0.0106
Echinococcus multilocularis pyruvate kinase 0.0034 0.0063 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0224 0.0224
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.0489 0.2434
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0024 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0489 0.2434
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0015 0.0044
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0089 0.0322
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.0093 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0088
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0077

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 nM Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting ChEMBL. 19740658
IC50 (binding) = 24 nM Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting ChEMBL. 19740658
IC50 (binding) = 744 uM Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting ChEMBL. 19740658
Ki (binding) Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells ChEMBL. 19740658

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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