Detailed information for compound 1080150

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 594.564 | Formula: C28H21F3N6O4S
  • H donors: 2 H acceptors: 5 LogP: 3.99 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1N(CCc2c1n(nc2C(F)(F)F)c1cccc(c1)c1n[nH]c(=O)[nH]1)c1ccc(cc1)c1ccccc1S(=O)(=O)C
  • InChi: 1S/C28H21F3N6O4S/c1-42(40,41)22-8-3-2-7-20(22)16-9-11-18(12-10-16)36-14-13-21-23(26(36)38)37(35-24(21)28(29,30)31)19-6-4-5-17(15-19)25-32-27(39)34-33-25/h2-12,15H,13-14H2,1H3,(H2,32,33,34,39)
  • InChiKey: LOIQROHBNJYIKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protease, serine, 1 (trypsin 1) References
Homo sapiens protease, serine, 3 Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens protease, serine, 2 (trypsin 2) References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni cercarial elastase (S01 family) protease, serine, 2 (trypsin 2) 247 aa 240 aa 25.8 %
Schistosoma mansoni cercarial elastase (S01 family) protease, serine, 3 261 aa 234 aa 25.2 %
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0029
Schistosoma mansoni lamin 0.0027 0.0188 0.0187
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0092 0.0241
Schistosoma mansoni P2X receptor subunit 0.0066 0.0671 0.067
Schistosoma mansoni smad 0.0024 0.0151 0.015
Brugia malayi Thioredoxin reductase 0.0063 0.0634 0.1023
Brugia malayi nuclear hormone receptor 0.002 0.0099 0.0158
Onchocerca volvulus 0.0057 0.0563 0.1341
Loa Loa (eye worm) hypothetical protein 0.0057 0.0563 0.0909
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0096 0.001
Brugia malayi MH2 domain containing protein 0.0354 0.4273 0.6913
Loa Loa (eye worm) animal heme peroxidase 0.024 0.2851 0.4611
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0933 1
Echinococcus granulosus importin subunit beta 1 0.003 0.022 0.0219
Brugia malayi steroid hormone receptor 0.002 0.0099 0.0158
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0367 0.4436 0.4435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0295 0.0769
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.3839 1
Brugia malayi Probable ClpP-like protease 0.0087 0.0933 0.1509
Giardia lamblia Thymus-specific serine protease precursor 0.002 0.0096 0.001
Echinococcus granulosus FTZ F1 alpha 0.002 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0629
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.023
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0121 0.0077
Loa Loa (eye worm) prolyl oligopeptidase 0.0041 0.0362 0.0583
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.0197
Schistosoma mansoni hypothetical protein 0.0028 0.0202 0.0201
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.067 0.1713
Onchocerca volvulus 0.0057 0.0563 0.1341
Loa Loa (eye worm) hypothetical protein 0.0118 0.1325 0.2143
Onchocerca volvulus 0.0118 0.1325 0.3162
Mycobacterium ulcerans hypothetical protein 0.0118 0.1325 0.684
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0367 0.4436 0.4435
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0933 0.2245
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0084 0.0902 0.2666
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0277 0.3308 0.3308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0152 0.0396
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0362 0.2565
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.022 0.0495
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.3839 1
Loa Loa (eye worm) carboxylesterase 0.0057 0.0563 0.0909
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0121 0.0227
Schistosoma mansoni hypothetical protein 0.0813 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.056 0.0509
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0152 0.0395
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0562 0.0908
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0116 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0152 0.0395
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Echinococcus granulosus transmembrane protease serine 3 0.0028 0.0202 0.0201
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0151 0.015
Brugia malayi hypothetical protein 0.0298 0.3567 0.577
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.041 0.1007
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Echinococcus multilocularis peroxidasin 0.024 0.2851 0.285
Schistosoma mansoni peroxidasin 0.024 0.2851 0.285
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Onchocerca volvulus Chorion peroxidase homolog 0.024 0.2851 0.6805
Plasmodium vivax importin-beta 2, putative 0.003 0.022 0.1476
Mycobacterium tuberculosis Conserved protein 0.0118 0.1325 0.1342
Brugia malayi Smad1 0.0024 0.0151 0.0243
Plasmodium falciparum importin beta, putative 0.003 0.022 0.1618
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0362 0.0719
Echinococcus granulosus acetylcholinesterase 0.0338 0.4069 0.4068
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.3839 1
Echinococcus multilocularis musashi 0.0027 0.0188 0.0187
Brugia malayi glutathione reductase 0.0063 0.0634 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Brugia malayi Carboxylesterase family protein 0.0057 0.0563 0.0909
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0175 0.1084
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0029
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0096 0.001
Echinococcus multilocularis BC026374 protein (S09 family) 0.0057 0.0563 0.0562
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0123 0.0721
Onchocerca volvulus 0.0057 0.0563 0.1341
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.002 0.0096 0.0095
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0057 0.0563 0.1466
Brugia malayi prolyl oligopeptidase family protein 0.0084 0.0902 0.1458
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0705 0.0704
Brugia malayi ecdysteroid receptor 0.002 0.0099 0.0158
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.056 0.0509
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0028 0.0202 0.0201
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0099 0.0098
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0099 0.0098
Schistosoma mansoni lamin 0.0027 0.0188 0.0187
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.0197
Brugia malayi hypothetical protein 0.0028 0.0202 0.0325
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.004 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0184 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0184 0.048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0081
Schistosoma mansoni ferritin 0.0026 0.017 0.0169
Mycobacterium leprae conserved hypothetical protein 0.0118 0.1325 0.7179
Onchocerca volvulus 0.0118 0.1325 0.3162
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0028 0.0202 0.0201
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0051 0.0081
Brugia malayi RNA binding protein 0.0068 0.0705 0.114
Loa Loa (eye worm) hypothetical protein 0.002 0.0096 0.0154
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0933 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0099 0.0158
Schistosoma mansoni intermediate filament proteins 0.0027 0.0188 0.0187
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0507 0.6181 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0099 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0099 0.0158
Trypanosoma brucei oligopeptidase b 0.0118 0.1325 0.3486
Echinococcus granulosus enteropeptidase 0.0028 0.0202 0.0201
Plasmodium falciparum glutathione reductase 0.0022 0.0121 0.0453
Brugia malayi Carboxylesterase family protein 0.0338 0.4069 0.6582
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0121 0.0316
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0096 0.001
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0671 0.067
Mycobacterium tuberculosis Conserved protein 0.0118 0.1325 0.1342
Brugia malayi hypothetical protein 0.0026 0.0175 0.0281
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0038 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0266 0.0694
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0092 0.0241
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0121 0.0227
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2773 0.7224
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0325
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0118 0.1325 0.2143
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.002 0.0096 0.0159
Brugia malayi RNA, U transporter 1 0.0084 0.0904 0.1461
Mycobacterium tuberculosis Probable lipase LipE 0.0118 0.1325 0.1342
Echinococcus multilocularis ferritin 0.0026 0.017 0.0169
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0347 0.4189 0.4188
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0223 0.1496
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.0933 0.0932
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0705 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0158
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0099 0.0158
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0669 0.0668
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1895 0.1963
Brugia malayi Carboxylesterase family protein 0.0057 0.0563 0.0909
Mycobacterium tuberculosis Probable esterase LipL 0.0118 0.1325 0.1342
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0099 0.0098
Schistosoma mansoni neuroligin 3 (S09 family) 0.0057 0.0563 0.0562
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0223 0.0607
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0277 0.3308 0.8852
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0099 0.0158
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0396 0.0969
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0121 0.0712
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0118 0.1325 0.684
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.041 0.0409
Brugia malayi Serine carboxypeptidase S28 family protein 0.002 0.0096 0.0154
Echinococcus multilocularis dnaJ subfamily B 0.0813 1 1
Onchocerca volvulus 0.0027 0.0188 0.0446
Echinococcus multilocularis lamin dm0 0.0027 0.0188 0.0187
Echinococcus multilocularis smad 0.0024 0.0151 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.3839 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0563 0.0909
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0081
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0118 0.1325 0.1342
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0118 0.1325 0.3486
Schistosoma mansoni P2X receptor subunit 0.0066 0.0671 0.067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.3839 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0118 0.1325 0.2143
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0325
Echinococcus granulosus tar DNA binding protein 0.0068 0.0705 0.0704
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Schistosoma mansoni ferritin 0.0026 0.017 0.0169
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0123 0.0122
Leishmania major trypanothione reductase 0.0063 0.0634 0.1613
Brugia malayi Carboxylesterase family protein 0.0338 0.4069 0.6582
Brugia malayi Peroxidasin 0.024 0.2851 0.4611
Schistosoma mansoni gliotactin 0.0057 0.0563 0.0562
Brugia malayi prolyl oligopeptidase family protein 0.0196 0.2297 0.3716
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0121 0.0227
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0248 0.295 0.295
Brugia malayi follicle stimulating hormone receptor 0.0507 0.6181 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0051 0.0081
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.4273 0.6913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0295 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0098
Echinococcus multilocularis GPCR, family 2 0.0125 0.1408 0.1407
Onchocerca volvulus Prolyl endopeptidase homolog 0.0277 0.3308 0.7898
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0281
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Brugia malayi prolyl oligopeptidase family protein 0.0277 0.3308 0.5351
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.3839 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0099 0.0098
Echinococcus multilocularis protein cereblon 0.0298 0.3567 0.3566
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0121 0.0227
Mycobacterium tuberculosis Probable peptidase 0.0118 0.1325 0.1342
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1023 0.1654
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0158
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.1749 0.1748
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.067 0.1713
Echinococcus granulosus neuroligin 0.0057 0.0563 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0232 0.0231
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0125 0.1408 0.1407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.1213 0.3616
Onchocerca volvulus Peroxidasin homolog 0.024 0.2851 0.6805
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.1325 0.3453
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0203 0.0202
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0202 0.0201
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0115 0.03
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0634 0.1613
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0151 0.015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0669 0.3199
Schistosoma mansoni hypothetical protein 0.0021 0.0116 0.0114
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0099 0.0098
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0236 0.2796 0.2944
Schistosoma mansoni nuclear hormone receptor 0.002 0.0099 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.027 0.3217 0.5203
Loa Loa (eye worm) hypothetical protein 0.0125 0.1408 0.2277
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0099 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0099 0.0158
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.015 0.0392
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0933 0.2762
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Schistosoma mansoni ferritin 0.0026 0.017 0.0169
Brugia malayi hypothetical protein 0.0152 0.1749 0.2828
Mycobacterium ulcerans beta-lactamase 0.0118 0.1325 0.684
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0099 0.0158
Brugia malayi intermediate filament protein 0.0027 0.0188 0.0302
Echinococcus granulosus beta LACTamase domain containing family member 0.0118 0.1325 0.1324
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0671 0.067
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.1325 0.3485
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0121 0.0161
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0118 0.1325 0.1342
Schistosoma mansoni thyroid hormone receptor 0.0268 0.3199 0.3199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.3839 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0099 0.0098
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0099 0.0158
Onchocerca volvulus 0.024 0.2851 0.6805
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.0634 0.0589
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.1325 0.3453
Echinococcus multilocularis para nitrobenzyl esterase 0.0057 0.0563 0.0562
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0099 0.0098
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.0933 0.0932
Schistosoma mansoni peroxidasin 0.024 0.2851 0.285
Schistosoma mansoni P2X receptor subunit 0.0066 0.0671 0.067
Schistosoma mansoni hypothetical protein 0.0248 0.295 0.295
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.1798 0.1857
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0121 0.012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0125 0.1408 0.1407
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0041 0.0362 0.0877
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0084 0.0902 0.0901
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0394 0.4775 0.7725
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0563 0.0562
Onchocerca volvulus Arrow homolog 0.0016 0.0051 0.012
Echinococcus granulosus para nitrobenzyl esterase 0.0057 0.0563 0.0562
Echinococcus multilocularis prolyl endopeptidase 0.0277 0.3308 0.3308
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Loa Loa (eye worm) hypothetical protein 0.0277 0.3308 0.5351
Trichomonas vaginalis helicase, putative 0.0013 0.0011 0.0029
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.067 0.1083
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0084 0.0083
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0347 0.4189 0.4188
Echinococcus multilocularis thyroid hormone receptor alpha 0.0268 0.3199 0.3199
Entamoeba histolytica hypothetical protein 0.0152 0.1749 0.4422
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0092 0.0149
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.067 0.0669
Schistosoma mansoni hypothetical protein 0.0028 0.0202 0.0201
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0092 0.0148
Mycobacterium ulcerans carboxylesterase, LipT 0.0057 0.0563 0.2609
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0121 0.0032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0396 0.0969
Brugia malayi Trypsin family protein 0.0028 0.0202 0.0325
Schistosoma mansoni hypothetical protein 0.0125 0.1408 0.1407
Schistosoma mansoni BC026374 protein (S09 family) 0.0057 0.0563 0.0562
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0202 0.0201
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0125 0.1408 0.2277
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0296 0.0698
Schistosoma mansoni ferritin 0.0026 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.0298 0.3567 0.577
Echinococcus granulosus laminin 0.0016 0.0051 0.005
Brugia malayi Muscleblind-like protein 0.0176 0.2049 0.3314
Loa Loa (eye worm) hypothetical protein 0.0316 0.3794 0.6137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0121 0.0227
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Echinococcus granulosus Mastin 0.0028 0.0202 0.0201
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Brugia malayi Fibulin-1 precursor 0.0016 0.0051 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0099 0.0158
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0188 0.0302
Brugia malayi MH1 domain containing protein 0.0013 0.0016 0.0025
Onchocerca volvulus 0.0028 0.0202 0.048
Toxoplasma gondii serine carboxypeptidase s28 protein 0.002 0.0096 0.0211
Loa Loa (eye worm) hypothetical protein 0.0176 0.2049 0.3314
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0121 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0013 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0394 0.4775 0.7725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.041 0.1067
Mycobacterium tuberculosis Conserved protein 0.0118 0.1325 0.1342
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0121 0.0316
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0096 0.0154
Brugia malayi hypothetical protein 0.0017 0.006 0.0095
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.017 0.0288
Brugia malayi Carboxylesterase family protein 0.0057 0.0563 0.0909
Toxoplasma gondii hypothetical protein 0.0041 0.0362 0.102
Echinococcus granulosus geminin 0.0532 0.65 0.65
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0362 0.0583
Schistosoma mansoni hypothetical protein 0.027 0.3217 0.3216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0098
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0933 0.2762
Brugia malayi Trypsin family protein 0.0028 0.0202 0.0325
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0232 0.0231
Brugia malayi Kringle domain containing protein 0.0021 0.0116 0.0185
Onchocerca volvulus 0.0057 0.0562 0.1341
Schistosoma mansoni smad1 5 8 and 0.0024 0.0151 0.015
Loa Loa (eye worm) carboxylesterase 0.0057 0.0563 0.0909
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.017 0.0429
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0031 0.0048
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0041 0.0362 0.0583
Brugia malayi Trypsin family protein 0.0028 0.0202 0.0325
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0671 0.067
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0671 0.067
Brugia malayi hypothetical protein 0.024 0.2851 0.4611
Loa Loa (eye worm) hypothetical protein 0.0057 0.0563 0.0909
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0057 0.0563 0.0562
Echinococcus multilocularis enteropeptidase 0.0028 0.0202 0.0201
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.3733 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0175 0.1084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0121 0.0227
Onchocerca volvulus 0.0347 0.4189 1
Schistosoma mansoni hypothetical protein 0.0125 0.1408 0.1407
Entamoeba histolytica hypothetical protein, conserved 0.0298 0.3567 0.9275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0295 0.0769
Onchocerca volvulus Dual oxidase homolog 0.024 0.2851 0.6805
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0705 0.114
Brugia malayi Trypsin family protein 0.0347 0.4189 0.6776
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0029
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0051 0.0081
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0362 0.0719
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0121 0.0032
Echinococcus granulosus acylamino acid releasing enzyme 0.0041 0.0362 0.0361
Echinococcus multilocularis acetylcholinesterase 0.0338 0.4069 0.4068
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.0467
Loa Loa (eye worm) trypsin family protein 0.0028 0.0202 0.0325
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0099 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0152 0.0396
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0099 0.0158
Giardia lamblia Alanyl dipeptidyl peptidase 0.0041 0.0362 0.0719
Schistosoma mansoni smad1 5 8 and 0.0024 0.0151 0.015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3733 1
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.056 0.0559
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.0634 0.0633
Onchocerca volvulus 0.0234 0.2773 0.6619
Loa Loa (eye worm) RecQ helicase 0.0021 0.0115 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0295 0.0769
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0049 0.0078
Trypanosoma brucei prolyl oligopeptidase, putative 0.0118 0.1325 0.3486
Schistosoma mansoni hypothetical protein 0.0532 0.65 0.65
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.022 0.0495
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0092 0.0149
Schistosoma mansoni apoferritin-2 0.0026 0.017 0.0169
Schistosoma mansoni hypothetical protein 0.0532 0.65 0.65
Schistosoma mansoni ap endonuclease 0.0019 0.0092 0.0091
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0151 0.015
Leishmania major hypothetical protein, conserved 0.0118 0.1325 0.3485
Mycobacterium ulcerans hypothetical protein 0.0164 0.1895 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0099 0.0158
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0096 0.0251
Loa Loa (eye worm) glutathione reductase 0.0063 0.0634 0.1023
Toxoplasma gondii ABC1 family protein 0.0118 0.1325 0.3957
Echinococcus multilocularis importin subunit beta 1 0.003 0.022 0.0219
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0057 0.0563 0.0562
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1687 0.4465
Echinococcus multilocularis beta LACTamase domain containing family member 0.0118 0.1325 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0266 0.0694
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0362 0.0583
Onchocerca volvulus 0.024 0.2851 0.6805
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.3839 1
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.002 0.0096 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0099 0.0098
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0096 0.0154
Mycobacterium tuberculosis Carboxylesterase LipT 0.0057 0.0563 0.0512
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0933 0.4665
Schistosoma mansoni ferritin light chain 0.0026 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.0338 0.4069 0.6582
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0232 0.0231
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0115 0.03
Loa Loa (eye worm) hypothetical protein 0.0041 0.0362 0.0583
Schistosoma mansoni ferritin light chain 0.0026 0.017 0.0169
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0121 0.0288
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0099 0.0098
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0705 0.0704
Brugia malayi MH2 domain containing protein 0.0024 0.0151 0.0243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0705 0.114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0099 0.0158
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0084 0.0083
Trypanosoma cruzi prolyl endopeptidase 0.0277 0.3308 0.8852
Loa Loa (eye worm) acetylcholinesterase 1 0.0338 0.4069 0.6582
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Schistosoma mansoni Smad4 0.0024 0.0151 0.015
Entamoeba histolytica hypothetical protein 0.0024 0.015 0.0155
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.1749 0.1748
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.041 0.1007
Echinococcus multilocularis transmembrane protease serine 3 0.0028 0.0202 0.0201
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0051 0.0081
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0099 0.0158
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.008
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0367 0.4436 0.4435
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0123 0.0122
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0118 0.1325 0.1342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0099 0.0158
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0202 0.0201
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Brugia malayi MH1 domain containing protein 0.0013 0.0016 0.0025
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0196 0.2297 0.5484
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0116 0.0385
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0362 0.0719
Echinococcus granulosus glycoprotein Antigen 5 0.0028 0.0202 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0116 0.0211
Brugia malayi Latrophilin receptor protein 2 0.0125 0.1408 0.2277
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0081 0.0129
Schistosoma mansoni hypothetical protein 0.0298 0.3567 0.3566
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0325
Leishmania major GTP-binding protein, putative 0.0022 0.0123 0.023
Echinococcus multilocularis expressed protein 0.0026 0.017 0.0169
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0121 0.0227
Loa Loa (eye worm) blistered cuticle protein 3 0.024 0.2851 0.4611
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0116 0.0185
Trichomonas vaginalis importin beta-1, putative 0.0024 0.015 0.0392
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0096 0.0251
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.056 0.2616
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0121 0.0344
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3733 1
Echinococcus granulosus snurportin 1 0.0317 0.3807 0.3807
Trichomonas vaginalis esterase, putative 0.0118 0.1325 0.3453
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0671 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0213 0.0556
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0196 0.2297 0.2297
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.015 0.0392
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0099 0.0233
Echinococcus granulosus peroxidasin 0.024 0.2851 0.285
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0057 0.0563 0.0512
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0121 0.0227
Echinococcus multilocularis geminin 0.0532 0.65 0.65
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0181 0.0472
Plasmodium falciparum glutathione reductase 0.0063 0.0634 0.6475
Onchocerca volvulus 0.0118 0.1325 0.3162
Brugia malayi Animal haem peroxidase family protein 0.024 0.2851 0.4611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0181 0.0472
Brugia malayi Trypsin-like protease protein 5 0.0028 0.0202 0.0325
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0081
Brugia malayi hypothetical protein 0.0043 0.039 0.0629
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Schistosoma mansoni hypothetical protein 0.0125 0.1408 0.1407
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0705 0.0704
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0151 0.0243
Brugia malayi MH1 domain containing protein 0.0024 0.0151 0.0243
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0116 0.0114
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0099 0.0098
Echinococcus multilocularis glycoprotein Antigen 5 0.0028 0.0202 0.0201
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0705 0.0704
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0277 0.3308 0.3308
Brugia malayi beta-lactamase family protein 0.0118 0.1325 0.2143
Mycobacterium leprae Probable lipase LipE 0.0118 0.1325 0.7179
Loa Loa (eye worm) Smad1 0.0024 0.0151 0.0243
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0121 0.0227
Echinococcus multilocularis fibrillin 1 0.0016 0.0051 0.005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0121 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0232 0.0231
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0029
Brugia malayi Carboxylesterase family protein 0.0057 0.0563 0.0909
Brugia malayi Blistered cuticle protein 3 0.024 0.2851 0.4611
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0118 0.1325 0.6841
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0115 0.0184
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.002 0.0096 0.0095
Brugia malayi Pre-SET motif family protein 0.0031 0.0232 0.0373
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0266 0.0729
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.041 0.0847
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0232 0.0231
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.0634 0.1023
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.1798 0.9464
Onchocerca volvulus 0.0028 0.0202 0.048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0099 0.0158
Echinococcus multilocularis Mastin 0.0028 0.0202 0.0201
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0151 0.015
Onchocerca volvulus 0.002 0.0096 0.0227
Echinococcus granulosus protein cereblon 0.0298 0.3567 0.3566
Brugia malayi Calcitonin receptor-like protein seb-1 0.0394 0.4775 0.7725
Giardia lamblia Serine peptidase, putative 0.002 0.0096 0.001
Giardia lamblia Alanyl dipeptidyl peptidase 0.0041 0.0362 0.0719
Plasmodium vivax glutathione reductase, putative 0.0063 0.0634 0.4663
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0084 0.0902 0.2339
Brugia malayi TAR-binding protein 0.0068 0.0705 0.114
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0338 0.4069 0.4068
Onchocerca volvulus 0.0319 0.3836 0.9159
Mycobacterium tuberculosis Probable lipase LipD 0.0118 0.1325 0.1342
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0671 0.067
Echinococcus granulosus smad 0.0024 0.0151 0.015
Echinococcus granulosus Dipeptidyl peptidase 9 0.0084 0.0902 0.0901
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0099 0.0158
Loa Loa (eye worm) hypothetical protein 0.0118 0.1325 0.2143
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0755 0.9277 1
Echinococcus granulosus acetylcholinesterase 0.0338 0.4069 0.4068
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.3733 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0092 0.0149
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.0362 0.0942
Onchocerca volvulus Peroxidasin homolog 0.024 0.2851 0.6805
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0202 0.0201
Schistosoma mansoni importin beta-1 0.003 0.022 0.0219
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0292
Mycobacterium ulcerans hypothetical protein 0.0028 0.0202 0.0607
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0232 0.0231
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Onchocerca volvulus 0.0027 0.0188 0.0446
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0118 0.1325 0.3486
Loa Loa (eye worm) hypothetical protein 0.0057 0.0563 0.0909
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0099 0.0098
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0669 0.3199
Leishmania major importin beta-1 subunit, putative 0.0024 0.015 0.0305
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.004 0.0039
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.041 0.0847
Brugia malayi Animal haem peroxidase family protein 0.024 0.2851 0.4611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0295 0.0769
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0092 0.0488
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0084 0.0902 0.0901
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0121 0.0288
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0099 0.0233
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0092 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.3839 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0121 0.0032
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0028 0.0202 0.0201
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0248 0.295 0.295
Schistosoma mansoni cpg binding protein 0.006 0.0603 0.0602
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0028 0.0202 0.0201
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0669 0.0668
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0196 0.2297 0.2297
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Onchocerca volvulus 0.0057 0.0563 0.1341
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0355
Brugia malayi MH2 domain containing protein 0.0024 0.0151 0.0243
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0202 0.0201
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0098
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.004 0.0039
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.004 0.0039
Loa Loa (eye worm) RNA binding protein 0.0068 0.0705 0.114
Onchocerca volvulus 0.024 0.2851 0.6805
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0121 0.0453
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.067 0.1083
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0121 0.0161
Loa Loa (eye worm) beta-lactamase 0.0118 0.1325 0.2143
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.0933 0.4842
Brugia malayi Pre-SET motif family protein 0.0206 0.242 0.3914
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0158
Echinococcus granulosus Smad4 0.0024 0.0151 0.015
Loa Loa (eye worm) hypothetical protein 0.0118 0.1325 0.2143
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0118 0.1325 0.2143
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.0933 0.0932
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0196 0.2297 0.2297
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0121 0.0227
Brugia malayi nuclear receptor NHR-88 0.002 0.0099 0.0158
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0223 0.0349
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.242 0.3914
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.041 0.1007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0038 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.1325 0.3453
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.3839 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0175 0.0451
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1687 0.4465
Brugia malayi beta-lactamase family protein 0.0118 0.1325 0.2143
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0118 0.1325 0.1342
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0188 0.0302
Echinococcus granulosus expressed protein 0.0026 0.017 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0152 0.0395
Onchocerca volvulus 0.002 0.0099 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.041 0.1067
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0038 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0175 0.0372
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0121 0.0453
Plasmodium falciparum thioredoxin reductase 0.0063 0.0634 0.6475
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0051 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.1325 0.1324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.1325 0.1324
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0396 0.0969
Schistosoma mansoni ap endonuclease 0.0019 0.0092 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0266 0.0694
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0325
Loa Loa (eye worm) hypothetical protein 0.0347 0.4189 0.6776
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0563 0.0562
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.056 0.0559
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.023
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0099 0.0098
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Brugia malayi Animal haem peroxidase family protein 0.024 0.2851 0.4611
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1375 0.1374
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.1325 0.3453
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0325 0.0324
Onchocerca volvulus 0.0028 0.0202 0.048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0302
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.041 0.1007
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0121 0.0227
Schistosoma mansoni acetylcholinesterase 0.0057 0.0563 0.0562
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0121 0.0227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1023 0.1022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.0373
Echinococcus granulosus prolyl endopeptidase 0.0277 0.3308 0.3308
Loa Loa (eye worm) hypothetical protein 0.0176 0.2049 0.3314
Loa Loa (eye worm) hypothetical protein 0.0347 0.4189 0.6776
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0232 0.0231
Brugia malayi hypothetical protein 0.0057 0.0563 0.0909
Toxoplasma gondii exonuclease III APE 0.0019 0.0092 0.0199
Echinococcus granulosus GPCR family 2 0.0125 0.1408 0.1407
Loa Loa (eye worm) hypothetical protein 0.0118 0.1325 0.2143
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0041 0.0362 0.0361
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0151 0.015
Treponema pallidum NADH oxidase 0.0022 0.0121 0.0077
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.0634 0.4663
Trypanosoma cruzi oligopeptidase b 0.0118 0.1325 0.3486
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1023 0.1022
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0118 0.1325 0.3486
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0099 0.0098
Brugia malayi Animal haem peroxidase family protein 0.024 0.2851 0.4611
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0158
Echinococcus granulosus lamin 0.0027 0.0188 0.0187
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0125 0.1408 0.1407
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0038 0.0036
Onchocerca volvulus 0.0028 0.0202 0.048
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.041 0.1007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0152 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0099 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0099 0.0158
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0038 0.0059
Loa Loa (eye worm) nuclear factor I 0.0013 0.0016 0.0025
Plasmodium vivax SET domain protein, putative 0.0031 0.0232 0.1563
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Mycobacterium tuberculosis Probable hydrolase 0.0118 0.1325 0.1342
Brugia malayi Importin beta-1 subunit 0.003 0.022 0.0355
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.022 0.059
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.002 0.0096 0.0095
Loa Loa (eye worm) hypothetical protein 0.0087 0.0933 0.1509
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0041 0.0362 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0362 0.0942
Echinococcus granulosus ferritin 0.0026 0.017 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0328 0.0854
Trichomonas vaginalis spcc417.12 protein, putative 0.0057 0.0563 0.1466
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1023 0.1022
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.041 0.0661
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0225 0.0587
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1023 0.1654
Plasmodium falciparum peptidase, putative 0.0041 0.0362 0.3278
Loa Loa (eye worm) hypothetical protein 0.002 0.0096 0.0154
Toxoplasma gondii thioredoxin reductase 0.0063 0.0634 0.1849
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1687 0.4465
Plasmodium vivax hypothetical protein, conserved 0.0118 0.1325 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0266 0.0694
Loa Loa (eye worm) hypothetical protein 0.0118 0.1325 0.2143
Onchocerca volvulus 0.0028 0.0202 0.048
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0096 0.0159
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0082 0.0121
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0049 0.0078
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.067 0.1713
Schistosoma mansoni cpg binding protein 0.0057 0.0562 0.0561
Entamoeba histolytica Ran family GTPase 0.0022 0.0123 0.008
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0059 0.0058
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.017 0.0429
Schistosoma mansoni thyroid hormone receptor 0.0268 0.3199 0.3199
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.067 0.0669
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0223 0.1649
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0092 0.0148
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0669 0.1709
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.1325 0.3485
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.067 0.1713
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0115 0.0114
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.041 0.1007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0515 0.1293
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.0634 0.0633
Onchocerca volvulus 0.0031 0.0232 0.0551
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.3807 0.6159
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0031 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1023 0.1022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0184 0.048
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0084 0.0902 0.2339
Toxoplasma gondii hypothetical protein 0.003 0.0223 0.0598
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0096 0.0251
Schistosoma mansoni ran 0.0022 0.0123 0.0122
Loa Loa (eye worm) animal heme peroxidase 0.024 0.2851 0.4611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.041 0.1067
Echinococcus multilocularis carboxylesterase 5A 0.0338 0.4069 0.4068
Schistosoma mansoni hypothetical protein 0.0317 0.3807 0.3807
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0121 0.0344
Trypanosoma brucei prolyl endopeptidase 0.0277 0.3308 0.8852
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0121 0.0227
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.017 0.0206
Echinococcus multilocularis acetylcholinesterase 0.0338 0.4069 0.4068
Loa Loa (eye worm) animal heme peroxidase 0.024 0.2851 0.4611
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0118 0.1325 0.3486
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0099 0.0098
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0396 0.0969
Onchocerca volvulus Peroxidase homolog 0.024 0.2851 0.6805
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0121 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0099 0.0158
Schistosoma mansoni ran 0.0022 0.0123 0.0122
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0041 0.0362 0.102
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0099 0.0158
Schistosoma mansoni cpg binding protein 0.006 0.0603 0.0602
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0118 0.1325 0.718
Onchocerca volvulus Peroxidase homolog 0.024 0.2851 0.6805
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0013 0.0012
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0051 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0096 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0096 0.0251
Loa Loa (eye worm) hypothetical protein 0.0338 0.4069 0.6582
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0116 0.0114
Schistosoma mansoni smad1 5 8 and 0.0024 0.0151 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0175 0.0372
Schistosoma mansoni hypothetical protein 0.0125 0.1408 0.1407
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.1749 0.1748
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0362 0.0877
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0705 0.0704
Echinococcus multilocularis lamin 0.0027 0.0188 0.0187
Schistosoma mansoni P2X receptor subunit 0.0066 0.0671 0.067
Toxoplasma gondii hypothetical protein 0.005 0.0476 0.1368
Brugia malayi CXXC zinc finger family protein 0.0057 0.0562 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0099 0.0158
Loa Loa (eye worm) hypothetical protein 0.0057 0.0563 0.0909
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0121 0.0227
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0121 0.0161
Loa Loa (eye worm) hypothetical protein 0.002 0.0096 0.0154
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.041 0.0409
Schistosoma mansoni coup transcription factor 0.002 0.0099 0.0098
Plasmodium falciparum thioredoxin reductase 0.0022 0.0121 0.0453
Brugia malayi Animal haem peroxidase family protein 0.024 0.2851 0.4611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0098
Onchocerca volvulus 0.0021 0.0116 0.0273
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.015 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0041 0.0362 0.0942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1023 0.1022
Trypanosoma brucei trypanothione reductase 0.0063 0.0634 0.1613
Trypanosoma cruzi oligopeptidase b 0.0118 0.1325 0.3486
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0362 0.0719
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0121 0.0227
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.017 0.0084
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.067 0.0669
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0232 0.0624
Brugia malayi Protein kinase domain containing protein 0.0021 0.0116 0.0185
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0125 0.1408 0.1407
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0099 0.0158
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0096 0.0159
Loa Loa (eye worm) latrophilin receptor protein 2 0.0125 0.1408 0.2277
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0362 0.0719
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0029
Echinococcus granulosus carboxylesterase 5A 0.0338 0.4069 0.4068
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0175 0.1125
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.017 0.0084
Echinococcus granulosus cpg binding protein 0.006 0.0603 0.0602
Echinococcus granulosus intermediate filament protein 0.0027 0.0188 0.0187
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.057 0.0921
Brugia malayi hypothetical protein 0.0121 0.1363 0.2204
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0933 0.4665
Loa Loa (eye worm) animal heme peroxidase 0.024 0.2851 0.4611
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.041 0.0409
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.1325 0.3453
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0121 0.0227
Loa Loa (eye worm) hypothetical protein 0.0057 0.0563 0.0909
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.067 0.1543
Mycobacterium ulcerans esterase/lipase LipP 0.0118 0.1325 0.684
Entamoeba histolytica hypothetical protein 0.0152 0.1749 0.4422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0099 0.0098
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0057 0.0563 0.0562
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0933 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0669 0.1081
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0188 0.0302
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0115 0.0208
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0151 0.0243
Treponema pallidum fructose-bisphosphate aldolase 0.0319 0.3839 1
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0096 0.0251
Echinococcus granulosus BC026374 protein S09 family 0.0057 0.0563 0.0562
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0158
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.4273 0.6913
Leishmania major hypothetical protein, conserved 0.0026 0.0175 0.0372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1023 0.1022
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0029
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.023
Brugia malayi beta-lactamase 0.0118 0.1325 0.2143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0266 0.0694
Brugia malayi MH1 domain containing protein 0.0024 0.0151 0.0243
Echinococcus multilocularis laminin 0.0016 0.0051 0.005
Echinococcus granulosus muscleblind protein 0.0176 0.2049 0.2048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0092 0.0149
Trichomonas vaginalis ferritin, putative 0.0026 0.017 0.0442
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0051 0.005
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0028 0.0202 0.0325
Echinococcus multilocularis Smad4 0.0024 0.0151 0.015
Mycobacterium ulcerans lipase LipD 0.0118 0.1325 0.684
Loa Loa (eye worm) hypothetical protein 0.024 0.2851 0.4611
Echinococcus granulosus lamin dm0 0.0027 0.0188 0.0187
Entamoeba histolytica hypothetical protein 0.0152 0.1749 0.4422
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0705 0.114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0121 0.0227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0099 0.0098
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0099 0.0098
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0296 0.0698
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.004 0.0039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0092 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0362 0.0877
Loa Loa (eye worm) prolyl oligopeptidase 0.0196 0.2297 0.3716
Echinococcus multilocularis cpg binding protein 0.006 0.0603 0.0602
Loa Loa (eye worm) hypothetical protein 0.0057 0.0563 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0099 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0152 0.0396
Loa Loa (eye worm) hypothetical protein 0.0394 0.4775 0.7725
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.041 0.0661
Echinococcus granulosus Tolloid protein 1 0.0016 0.0051 0.005
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0362 0.0719
Schistosoma mansoni cercarial elastase (S01 family) 0.0028 0.0202 0.0201
Schistosoma mansoni apoferritin-2 0.0026 0.017 0.0169
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0099 0.0098
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0669 0.0628
Echinococcus multilocularis neuroligin 0.0057 0.0563 0.0562
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.1325 0.3485
Onchocerca volvulus 0.0057 0.0563 0.1341
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0116 0.027
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.0933 1
Leishmania major hypothetical protein, conserved 0.0021 0.0116 0.0211
Trichomonas vaginalis ran, putative 0.0022 0.0123 0.0319
Toxoplasma gondii prolyl endopeptidase 0.0277 0.3308 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0057 0.0563 0.0512
Leishmania major oligopeptidase b 0.0118 0.1325 0.3486
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0029
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0084 0.0902 0.2339
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0121 0.0195
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0092 0.0091
Echinococcus multilocularis acylamino acid releasing enzyme 0.0041 0.0362 0.0361
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.1798 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.017 0.0919
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0099 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0099 0.0158
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0084 0.0902 0.2339
Schistosoma mansoni hypothetical protein 0.0152 0.1749 0.1748
Echinococcus multilocularis snurportin 1 0.0317 0.3807 0.3807
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0669 0.0668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0266 0.0694
Giardia lamblia Fructose-bisphosphate aldolase 0.0319 0.3839 1
Echinococcus multilocularis muscleblind protein 1 0.0176 0.2049 0.2048
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0202 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0266 0.0694
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0051 0.0074
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0121 0.0712
Giardia lamblia GTOR 0.0045 0.041 0.0847
Loa Loa (eye worm) carboxylesterase 0.0338 0.4069 0.6582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0099 0.0158
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.0116 0.0185
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0084 0.0134
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0084 0.0902 0.2339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1023 0.1022
Echinococcus multilocularis muscleblind protein 0.0176 0.2049 0.2048
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0175 0.0372
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0325 0.0324
Onchocerca volvulus Protein cereblon homolog 0.0298 0.3567 0.8516
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0296 0.0698
Schistosoma mansoni egf-like domain protein 0.0016 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0081
Loa Loa (eye worm) hypothetical protein 0.027 0.3217 0.5203
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0123 0.0291
Echinococcus granulosus bloom syndrome protein 0.0021 0.0115 0.0114
Entamoeba histolytica hypothetical protein 0.0152 0.1749 0.4422
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0325
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0933 0.6976

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.2 nM Inhibition of human factor 10a ChEMBL. 20100660
Ki (binding) > 4200 nM Inhibition of human trypsin ChEMBL. 20100660
Ki (binding) > 6000 nM Inhibition of human factor 2a ChEMBL. 20100660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.