Detailed information for compound 1098422

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.321 | Formula: C17H18O6
  • H donors: 3 H acceptors: 4 LogP: 1.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](C(=O)c1ccc(c(c1)OC)O)c1ccc(c(c1)OC)O
  • InChi: 1S/C17H18O6/c1-22-15-7-10(3-5-13(15)19)12(9-18)17(21)11-4-6-14(20)16(8-11)23-2/h3-8,12,18-20H,9H2,1-2H3/t12-/m1/s1
  • InChiKey: QMYGRGKKZBRZKH-GFCCVEGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.003 0.0045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.0053
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.001 0.0011
Schistosoma mansoni ferritin 0.0026 0.0041 0.0074
Schistosoma mansoni apoferritin-2 0.0026 0.0041 0.0074
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0048 0.2141
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0215 0.2273
Echinococcus multilocularis nibrin 0.001 0.0003 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0215 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0183 0.8489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0314 0.0578
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0003 0.0003
Onchocerca volvulus 0.0021 0.003 0.0051
Loa Loa (eye worm) RNA binding protein 0.0127 0.0289 0.0453
Onchocerca volvulus 0.0495 0.1185 0.2185
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0003 0.0022
Entamoeba histolytica Ran family GTPase 0.0021 0.0029 0.0282
Leishmania major importin beta-1 subunit, putative 0.0023 0.0034 0.0038
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0001 0.0000055386
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0202 0.1702
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0202 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.003 0.0045
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.0207 0.0484 0.0892
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0097 0.0215 0.0336
Plasmodium vivax glutathione reductase, putative 0.0037 0.0068 0.3296
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0843 0.2034 0.3757
Brugia malayi hypothetical protein 0.0011 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0037 0.0066
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0000029975
Trypanosoma brucei C-8 sterol isomerase, putative 0.2619 0.6362 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0048 0.0071
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0314 0.0578
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0069 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Brugia malayi ecdysteroid receptor 0.0021 0.003 0.0045
Brugia malayi hypothetical protein 0.001 0.0003 0.0003
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0048 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0021 0.003 0.0053
Onchocerca volvulus 0.0097 0.0215 0.0392
Brugia malayi steroid hormone receptor 0.0021 0.003 0.0045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0303 0.0718 0.1126
Schistosoma mansoni nuclear hormone receptor 0.0021 0.003 0.0053
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0064 0.1054
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0048 0.2519
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0005 0.0006
Schistosoma mansoni smad1 5 8 and 0.0024 0.0037 0.0066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0303 0.0718 0.1126
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0064 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Brugia malayi nuclear receptor NHR-88 0.0021 0.003 0.0045
Schistosoma mansoni hypothetical protein 0.0096 0.0213 0.0391
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0064 0.0537
Toxoplasma gondii patched family protein 0.0024 0.0037 0.1719
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0215 0.0336
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Onchocerca volvulus 0.0024 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Toxoplasma gondii hypothetical protein 0.0024 0.0037 0.1719
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.003 0.0029
Brugia malayi Patched related family protein 12 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0097 0.0215 0.0336
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0132 0.0242
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0005 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0215 0.4011
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0023 0.532
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.007 0.0126
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0048 0.0087
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0048 0.2284
Echinococcus granulosus expressed protein 0.0026 0.0041 0.0074
Mycobacterium leprae Probable lipase LipE 0.0035 0.0064 0.2875
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0003 0.0003
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.0183 1
Schistosoma mansoni hypothetical protein 0.0299 0.0707 0.1304
Onchocerca volvulus 0.001 0.0003 0.0001
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0003 0.0002
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0048 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.003 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Schistosoma mansoni ferritin 0.0026 0.0041 0.0074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0047 0.0072
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0202 0.037
Onchocerca volvulus Protein patched homolog 0.0024 0.0037 0.0063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.0045
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.2141
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0034 0.0287
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0005 0.0007
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Brugia malayi beta-lactamase family protein 0.0035 0.0064 0.0098
Brugia malayi Smad1 0.0024 0.0037 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0064 0.0537
Echinococcus multilocularis protein patched 0.0169 0.039 0.0389
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0132 0.0242
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.003 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.0196
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0048 0.075
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0314 0.0578
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0146 0.2656
Toxoplasma gondii ABC1 family protein 0.0035 0.0064 0.3066
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Mycobacterium ulcerans hypothetical protein 0.0035 0.0064 0.2875
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0023 0.0032
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.001 0.0011
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0068 0.3296
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.0041
Loa Loa (eye worm) hypothetical protein 0.0097 0.0215 0.0336
Schistosoma mansoni smad1 5 8 and 0.0024 0.0037 0.0066
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.001 0.0016
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0029 0.1322
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0037 0.0056
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0009
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0002 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0132 0.6488
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0037 0.0066
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.001 0.0358
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0006 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0064 0.1054
Schistosoma mansoni apoferritin-2 0.0026 0.0041 0.0074
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0003 0.0000036781
Schistosoma mansoni nuclear receptor 0.001 0.0003 0.0003
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.1458
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.003 0.0053
Schistosoma mansoni ap endonuclease 0.0018 0.0023 0.0041
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0003 0.0002
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0003
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0005 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.003 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Brugia malayi MH2 domain containing protein 0.0351 0.0835 0.1311
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.001 0.0335
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni inositol transporter 0.0037 0.007 0.0126
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0069 0.0068
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0041 0.1824
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0097 0.0215 0.4011
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0202 0.1702
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Echinococcus multilocularis geminin 0.0843 0.2034 0.2033
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0003 0.0003
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.001 0.0467
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0163 0.0375 0.0691
Loa Loa (eye worm) hypothetical protein 0.0303 0.0718 0.1126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.003 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.003 0.0045
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0048 0.2141
Onchocerca volvulus 0.0028 0.0048 0.0084
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.001 0.0394
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2229 0.5413 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0097 0.0215 1
Brugia malayi MH1 domain containing protein 0.0024 0.0037 0.0056
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.0045
Echinococcus granulosus high affinity choline transporter 1 0.0338 0.0802 0.148
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0034 0.0287
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0064 0.0098
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0041 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Onchocerca volvulus 0.0028 0.0047 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.003 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0048 0.0071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.1038 0.1631
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0064 0.1054
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0002 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.0484 0.0759
Echinococcus granulosus Niemann Pick C1 protein 0.0393 0.0937 0.1729
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0048 0.0406
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0206 0.9562
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.0053
Brugia malayi hypothetical protein 0.0011 0.0006 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.0029
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.001 0.0082
Trypanosoma brucei trypanothione reductase 0.0037 0.0068 0.0103
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0003
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0048 0.006
Brugia malayi tailless protein 0.001 0.0003 0.0003
Mycobacterium ulcerans beta-lactamase 0.0035 0.0064 0.2875
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0023 0.1035
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.003 0.0051
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0048 0.0071
Schistosoma mansoni transcription factor LCR-F1 0.0255 0.06 0.1107
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0048 0.075
Loa Loa (eye worm) oxidoreductase 0.0028 0.0048 0.0074
Schistosoma mansoni smad 0.0011 0.0005 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0006 0.0009
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Entamoeba histolytica hypothetical protein 0.0255 0.06 0.6397
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0048 0.075
Onchocerca volvulus 0.0028 0.0048 0.0084
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0183 0.3384
Schistosoma mansoni importin beta-1 0.0028 0.0047 0.0085
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0048 0.0087
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0005 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0314 0.0313
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0029 0.1322
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0048 0.2284
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0003 0.0022
Echinococcus multilocularis expressed protein 0.0026 0.0041 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0064 0.0115
Brugia malayi Patched related family protein 10 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.0041
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0314 0.0492
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0048 0.0071
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0064 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.075
Schistosoma mansoni cpg binding protein 0.0029 0.0051 0.0091
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0064 0.1054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Leishmania major C-8 sterol isomerase-like protein 0.2619 0.6362 1
Echinococcus multilocularis protein dispatched 1 0.0192 0.0448 0.0447
Schistosoma mansoni sodium/solute symporter 0.0037 0.007 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0001 0.0000055386
Loa Loa (eye worm) hypothetical protein 0.0028 0.0048 0.0074
Echinococcus granulosus histone acetyltransferase KAT2B 0.0302 0.0715 0.132
Loa Loa (eye worm) beta-lactamase 0.0035 0.0064 0.0098
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0399 0.0952 0.1756
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0311 0.0737 0.1359
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0003 0.0003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0023 0.0022
Echinococcus granulosus Smad4 0.0024 0.0037 0.0066
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0393 0.0937 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0132 0.0242
Schistosoma mansoni Smad4 0.0011 0.0005 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.001 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.003 0.0029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0213 0.0391
Mycobacterium tuberculosis Conserved protein 0.0035 0.0064 0.1054
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0048 0.2141
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni hypothetical protein 0.0163 0.0375 0.0691
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.007 0.0068
Brugia malayi Nuclear hormone receptor E75 0.001 0.0003 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0495 0.1185 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0003 0.0003
Brugia malayi topoisomerase 0.001 0.0003 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Echinococcus multilocularis cpg binding protein 0.0029 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Echinococcus granulosus snurportin 1 0.0299 0.0707 0.1304
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.0041
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.003 0.0053
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0023 0.1141
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0023 0.0221
Onchocerca volvulus 0.0024 0.0037 0.0063
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.0196
Brugia malayi RNA, U transporter 1 0.008 0.0173 0.027
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Brugia malayi hypothetical protein 0.0024 0.0037 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Echinococcus granulosus Protein patched homolog 1 0.0169 0.039 0.0718
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0202 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0048 0.075
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.001 0.0011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0097 0.0215 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0146 0.2656
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.007 0.0068
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni ran 0.0021 0.0029 0.0051
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.001 0.0082
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0041 1
Loa Loa (eye worm) hypothetical protein 0.2619 0.6362 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.001 0.0016
Schistosoma mansoni cpg binding protein 0.0028 0.0047 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.0044
Brugia malayi GH02984p 0.0338 0.0802 0.1259
Schistosoma mansoni patched 1 0.0169 0.039 0.0718
Onchocerca volvulus 0.0024 0.0037 0.0063
Schistosoma mansoni ferritin 0.0026 0.0041 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0215 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0048 0.2284
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.003 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.003 0.0045
Brugia malayi MH2 domain containing protein 0.0011 0.0005 0.0006
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0064 0.0115
Schistosoma mansoni topbp1 0.001 0.0003 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Echinococcus granulosus nibrin 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0289 0.0453
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0048 0.2141
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0006 0.0009
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0129 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.0045
Schistosoma mansoni hypothetical protein 0.0843 0.2034 0.3757
Schistosoma mansoni hypothetical protein 0.0096 0.0213 0.0391
Plasmodium falciparum glutathione reductase 0.0037 0.0068 0.3635
Onchocerca volvulus 0.0037 0.007 0.0124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi glutathione reductase 0.0037 0.0068 0.0105
Brugia malayi Niemann-Pick C1 protein precursor 0.0393 0.0937 0.1471
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0048 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Entamoeba histolytica hypothetical protein 0.0255 0.06 0.6397
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.001 0.0358
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.007 0.0068
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0003 0.0001
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0311 0.0737 0.0736
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.001 0.0011
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.003 0.0051
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0206 0.383
Loa Loa (eye worm) acetyltransferase 0.0311 0.0737 0.1156
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0132 0.65
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0048 0.006
Onchocerca volvulus 0.0035 0.0064 0.0113
Brugia malayi Myosin head containing protein 0.0024 0.0037 0.0056
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0034 0.0049
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0003 0.0002
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0048 0.0047
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0183 0.3384
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0163 0.0375 0.0691
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.0053
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.075
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0003 0.0002
Schistosoma mansoni smad1 5 8 and 0.0024 0.0037 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.007 0.3363
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0000055386
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0183 0.3384
Mycobacterium tuberculosis Probable reductase 0.0084 0.0183 0.3384
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0096 0.0213 0.0332
Plasmodium falciparum lipid/sterol:H+ symporter 0.0024 0.0037 0.1895
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0213 0.0211
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.003 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0255 0.06 0.0599
Toxoplasma gondii thioredoxin reductase 0.0037 0.0068 0.3296
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0215 0.2273
Treponema pallidum NADH oxidase 0.0013 0.001 0.1839
Brugia malayi nuclear receptor RXR 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Mycobacterium ulcerans lipase LipD 0.0035 0.0064 0.2875
Trichomonas vaginalis esterase, putative 0.0035 0.0064 0.0537
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0064 0.3066
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.0351 0.0835 0.1311
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0206 0.383
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.003 0.0045
Brugia malayi MH1 domain containing protein 0.0013 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0064 0.1054
Mycobacterium tuberculosis Conserved protein 0.0035 0.0064 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.039 0.3291
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.007 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.001 0.0011
Echinococcus granulosus vesicular acetylcholine transporter 0.2229 0.5413 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0213 0.0391
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0005 0.0004
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0005 0.0006
Brugia malayi hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) DR-78 0.001 0.0003 0.0003
Toxoplasma gondii patched family protein 0.0024 0.0037 0.1719
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.0053
Plasmodium falciparum glutathione reductase 0.0013 0.001 0.0394
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0215 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.003 0.0053
Plasmodium falciparum thioredoxin reductase 0.0037 0.0068 0.3635
Loa Loa (eye worm) hypothetical protein 0.1338 0.3241 0.5094
Schistosoma mansoni high-affinity choline transporter 0.0338 0.0802 0.148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0155 0.8456
Entamoeba histolytica hypothetical protein 0.0255 0.06 0.6397
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.001 0.0394
Echinococcus multilocularis GPCR, family 2 0.0096 0.0213 0.0211
Brugia malayi hypothetical protein 0.001 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0155 0.7667
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0023 0.1141
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.001 0.0335
Loa Loa (eye worm) nuclear factor I 0.0013 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0207 0.0482 0.0756
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0003 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0215 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0048 0.0071
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0048 0.2141
Echinococcus granulosus replication factor c subunit 1 0.001 0.0003 0.0003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0064 0.1054
Loa Loa (eye worm) Smad1 0.0024 0.0037 0.0056
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Brugia malayi RNA binding protein 0.0127 0.0289 0.0453
Schistosoma mansoni hypothetical protein 0.0096 0.0213 0.0391
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Brugia malayi nuclear hormone receptor 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0048 0.0074
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0206 0.383
Loa Loa (eye worm) hypothetical protein 0.0063 0.0132 0.0206
Onchocerca volvulus 0.0024 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Plasmodium vivax patched family protein, putative 0.0024 0.0037 0.1718
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni ran 0.0021 0.0029 0.0051
Schistosoma mansoni hypothetical protein 0.0255 0.06 0.1107
Loa Loa (eye worm) hypothetical protein 0.0393 0.0937 0.1471
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.007 0.0107
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni vesicular acetylcholine transporter 0.2229 0.5413 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.0029
Schistosoma mansoni ferritin 0.0026 0.0041 0.0074
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.0183 0.1932
Brugia malayi Thioredoxin reductase 0.0037 0.0068 0.0105
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0029 0.0028
Brugia malayi DKFZp564C0469 protein 0.001 0.0003 0.0002
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.003 0.0045
Entamoeba histolytica acyl-coA synthetase, putative 0.0097 0.0215 0.2273
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0048 0.075
Loa Loa (eye worm) hypothetical protein 0.0338 0.0802 0.1259
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.003 0.0045
Schistosoma mansoni zinc finger protein 0.001 0.0003 0.0003
Schistosoma mansoni smad 0.0024 0.0037 0.0066
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0037 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.003 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0314 0.0492
Brugia malayi Nuclear hormone receptor E75 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0048 0.0074
Plasmodium vivax importin-beta 2, putative 0.0028 0.0047 0.2227
Brugia malayi MH1 domain containing protein 0.0013 0.0011 0.0015
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.0022
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Plasmodium falciparum thioredoxin reductase 0.0013 0.001 0.0394
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0064 0.0096
Brugia malayi Patched related family protein 4 0.0024 0.0037 0.0056
Leishmania major hypothetical protein, conserved 0.0035 0.0064 0.0085
Schistosoma mansoni hypothetical protein 0.0163 0.0375 0.0691
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.0045
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2619 0.6362 1
Brugia malayi nuclear receptor RXR 0.0011 0.0006 0.0007
Plasmodium falciparum importin beta, putative 0.0028 0.0047 0.2456
Echinococcus granulosus FTZ F1 alpha 0.0021 0.003 0.0053
Brugia malayi beta-lactamase family protein 0.0035 0.0064 0.0098
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) glutathione reductase 0.0037 0.0068 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0146 0.2656
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0003 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0213 0.0211
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0064 0.2875
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0041 0.0618
Schistosoma mansoni ferritin light chain 0.0026 0.0041 0.0074
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0023 0.0032
Brugia malayi CXXC zinc finger family protein 0.0028 0.0047 0.0072
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.001 0.0335
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0064 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Schistosoma mansoni ap endonuclease 0.0018 0.0023 0.0041
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0068 0.1143
Brugia malayi protein C24B5.3 0.0024 0.0037 0.0056
Brugia malayi hypothetical protein 0.001 0.0003 0.0002
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0048 0.0406
Schistosoma mansoni hypothetical protein 0.0096 0.0213 0.0391
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0132 0.0242
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0125 0.0229
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0064 0.0096
Brugia malayi Pre-SET motif family protein 0.0063 0.0132 0.0206
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0068 0.0103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.003 0.0053
Trichomonas vaginalis ran, putative 0.0021 0.0029 0.0244
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0169 0.039 0.0611
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0023 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0289 0.0453
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.003 0.0045
Echinococcus multilocularis ferritin 0.0026 0.0041 0.004
Brugia malayi Pre-SET motif family protein 0.0435 0.1038 0.1631
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.001 0.0358
Brugia malayi beta-lactamase 0.0035 0.0064 0.0098
Echinococcus granulosus smad 0.0024 0.0037 0.0066
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0003 0.0022
Echinococcus multilocularis vesicular acetylcholine transporter 0.2229 0.5413 0.5412
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.003 0.0053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Echinococcus granulosus solute carrier family 5 0.0037 0.007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Schistosoma mansoni cpg binding protein 0.0029 0.0051 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Brugia malayi Importin beta-1 subunit 0.0028 0.0047 0.0072
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0064 0.0537
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Echinococcus granulosus expressed conserved protein 0.0369 0.0879 0.1621
Leishmania major trypanothione reductase 0.0037 0.0068 0.0092
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2229 0.5413 0.8507
Brugia malayi MH2 domain containing protein 0.0024 0.0037 0.0056
Echinococcus multilocularis Smad4 0.0024 0.0037 0.0036
Echinococcus granulosus cpg binding protein 0.0029 0.0051 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.003 0.0045
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0183 0.3384
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0003 0.0001
Brugia malayi hypothetical protein 0.0255 0.06 0.0942
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0048 0.2141
Echinococcus multilocularis high affinity choline transporter 1 0.0338 0.0802 0.0801
Schistosoma mansoni coup transcription factor 0.0021 0.003 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.0029
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0048 0.2141
Brugia malayi vesicular acetylcholine transporter unc-17 0.2229 0.5413 0.8507
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.003 0.0053
Echinococcus granulosus importin subunit beta 1 0.0028 0.0047 0.0085
Echinococcus granulosus tar DNA binding protein 0.0127 0.0289 0.0532
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0064 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0169 0.039 0.0611
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.001 0.0394
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0005 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0064 0.0537
Onchocerca volvulus 0.0035 0.0064 0.0113
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0155 1
Toxoplasma gondii patched family protein 0.0024 0.0037 0.1719
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0037 0.0036
Brugia malayi ERG2 and Sigma1 receptor like protein 0.2619 0.6362 1
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0041 0.1824
Leishmania major GTP-binding protein, putative 0.0021 0.0029 0.003
Schistosoma mansoni topbp1 0.001 0.0003 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0215 0.0323
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.007 0.0126
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0048 0.2141
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0034 0.0287
Trichomonas vaginalis ferritin, putative 0.0026 0.0041 0.0349
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0213 0.0332
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0015
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0336
Echinococcus multilocularis smad 0.0024 0.0037 0.0036
Plasmodium vivax SET domain protein, putative 0.0063 0.0132 0.65
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0064 0.1054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.001 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0047 0.007
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.007 0.0126
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Onchocerca volvulus Protein patched homolog 0.0024 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.003 0.0053
Mycobacterium ulcerans hypothetical protein 0.0097 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.003 0.0053
Brugia malayi CHE-14 protein 0.0169 0.039 0.0611
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0003 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.003 0.0053
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.1458
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0047 0.2227
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0213 0.0332
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0072
Echinococcus multilocularis solute carrier family 5 0.0037 0.007 0.0068
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.001 0.1839
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0215 0.0336
Echinococcus granulosus sterol regulatory element binding protein 0.0169 0.039 0.0718
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0023 0.532
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0132 0.0242
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0215 0.0323
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.001 0.0358
Brugia malayi Patched protein homolog 1 0.0024 0.0037 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0064 0.2875
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0048 0.2141
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0521 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0023 0.0032
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.001 0.0013
Onchocerca volvulus 0.0028 0.0048 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0215 0.0336
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0183 0.3384
Onchocerca volvulus 0.0024 0.0037 0.0063
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0289 0.0453
Echinococcus multilocularis expressed conserved protein 0.0369 0.0879 0.0878
Onchocerca volvulus 0.001 0.0003 0.0001
Brugia malayi protein C24B5.3 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0207 0.0484 0.0759
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0097 0.0215 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0048 0.2141
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0064 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.0045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0023 0.0264
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0097 0.0215 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0303 0.0718 0.1126
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.001 0.1839
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0041 0.1824
Schistosoma mansoni Smad4 0.0011 0.0005 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0314 0.0578
Brugia malayi nuclear receptor NHR-67 0.001 0.0003 0.0003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0005
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0003 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.003 0.0045
Brugia malayi conserved hypotetical protein 0.001 0.0003 0.0003
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0038 0.0561
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0001 0.0000029975
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0003 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.003 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.0393 0.0937 0.0936
Onchocerca volvulus 0.0035 0.0064 0.0113
Plasmodium vivax SET domain containing protein 0.0011 0.0004 0.0088
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0003 0.0003
Brugia malayi ecdysone receptor 0.001 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0048 0.075
Giardia lamblia Histone acetyltransferase GCN5 0.0084 0.0183 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0047 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0213 0.0332
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0707 0.1109
Brugia malayi nuclear receptor NHR-88 0.001 0.0003 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0351 0.0835 0.1311
Schistosoma mansoni inositol transporter 0.0037 0.007 0.0126
Schistosoma mansoni DNA ligase IV 0.001 0.0003 0.0003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0029 0.0051
Onchocerca volvulus 0.0024 0.0037 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0146 0.2656
Echinococcus multilocularis sterol regulatory element binding protein 0.0169 0.039 0.0389
Brugia malayi hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi MH1 domain containing protein 0.0024 0.0037 0.0056
Brugia malayi Sodium:solute symporter family protein 0.0037 0.007 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0215 0.0323
Onchocerca volvulus 0.0024 0.0037 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0002
Brugia malayi acetyltransferase, GNAT family protein 0.0311 0.0737 0.1156
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0023 0.097
Echinococcus granulosus geminin 0.0843 0.2034 0.3757
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0155 0.2844
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.0029
Brugia malayi MH2 domain containing protein 0.0024 0.0037 0.0056
Brugia malayi nuclear hormone receptor 0.0021 0.003 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0314 0.0313
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0005 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0132 0.0131
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0064 0.2875
Echinococcus granulosus ferritin 0.0026 0.0041 0.0074
Brugia malayi hypothetical protein 0.0024 0.0037 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0202 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.003 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0255 0.06 0.1107
Onchocerca volvulus 0.0028 0.0048 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0155 0.7188
Schistosoma mansoni nuclear receptor 0.001 0.0003 0.0003
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0041 0.0618
Schistosoma mansoni ferritin light chain 0.0026 0.0041 0.0074
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0003 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Toxoplasma gondii patched family protein 0.0024 0.0037 0.1719
Echinococcus granulosus GPCR family 2 0.0096 0.0213 0.0391
Echinococcus granulosus Niemann Pick C1 protein 0.0562 0.1348 0.2488
Echinococcus multilocularis Niemann Pick C1 protein 0.0562 0.1348 0.1347
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0068 0.0105
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0289 0.0288
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Brugia malayi TAR-binding protein 0.0127 0.0289 0.0453
Echinococcus multilocularis snurportin 1 0.0299 0.0707 0.0706
Mycobacterium tuberculosis Conserved protein 0.0035 0.0064 0.1054
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0048 0.2141
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.003 0.0053
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.075
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0048 0.2284
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0048 0.075
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0037 0.0056
Onchocerca volvulus 0.0063 0.0132 0.0239
Entamoeba histolytica hypothetical protein 0.0255 0.06 0.6397
Schistosoma mansoni Smad4 0.0024 0.0037 0.0066
Brugia malayi hypothetical protein 0.001 0.0003 0.0003
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0037 0.0066
Toxoplasma gondii exonuclease III APE 0.0018 0.0023 0.1035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0314 0.0578

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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