Detailed information for compound 1099513

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 280.361 | Formula: C19H20O2
  • H donors: 1 H acceptors: 1 LogP: 5.31 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCc1ccc(c(c1)c1cc(CC=C)ccc1O)OC
  • InChi: 1S/C19H20O2/c1-4-6-14-8-10-18(20)16(12-14)17-13-15(7-5-2)9-11-19(17)21-3/h4-5,8-13,20H,1-2,6-7H2,3H3
  • InChiKey: XVFDXLSYSCRNLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0084 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0072 0.0108
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0044 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0072 0.0066
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0044 0.0038
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0059 0.0079
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0076 0.0194 0.0303
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0072 0.0108
Onchocerca volvulus 0.0037 0.0059 0.0225
Loa Loa (eye worm) hypothetical protein 0.012 0.0347 0.0562
Plasmodium falciparum glutathione reductase 0.0032 0.0042 0.0052
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.0496 0.049
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0059 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.0326 0.032
Brugia malayi MH1 domain containing protein 0.0041 0.0075 0.0114
Plasmodium falciparum glutamine synthetase, putative 0.0076 0.0194 0.0303
Mycobacterium tuberculosis Conserved protein 0.0037 0.0059 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.025 0.0402
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.0656 0.1066
Leishmania major squalene synthase, putative 0.0556 0.1843 0.3027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.0739 0.1203
Loa Loa (eye worm) hexokinase 0.0183 0.0561 0.0916
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.045 0.148 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0609 0.2024 0.3331
Trypanosoma brucei hexokinase, putative 0.0183 0.0561 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0072 0.0108
Loa Loa (eye worm) hypothetical protein 0.0063 0.0149 0.0236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0044 0.0038
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.045 0.148 0.2427
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.045 0.148 0.2427
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0044 0.0055
Schistosoma mansoni Smad4 0.0041 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0008
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0076 0.0194 0.061
Loa Loa (eye worm) hypothetical protein 0.0044 0.0084 0.0129
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0084 0.0121
Brugia malayi glutathione reductase 0.0092 0.025 0.0402
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.045 0.148 0.2427
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0044 0.0055
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0084 0.0084
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0072 0.0066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0072 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0247 0.0783 0.1283
Mycobacterium ulcerans beta-lactamase 0.0037 0.0059 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0072 0.0108
Schistosoma mansoni smad 0.0041 0.0075 0.0075
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0072 0.0066
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0072 0.0072
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0072 0.0108
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0899 0.3021 0.4972
Echinococcus multilocularis lamin 0.0027 0.0024 0.0018
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0084 0.0078
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Leishmania major hypothetical protein, conserved 0.0173 0.0528 0.0854
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0427 0.0421
Brugia malayi nuclear receptor NHR-88 0.004 0.0072 0.0108
Mycobacterium tuberculosis Conserved protein 0.0037 0.0059 0.0079
Treponema pallidum hexokinase (hxk) 0.0183 0.0561 0.1827
Brugia malayi beta-lactamase family protein 0.0037 0.0059 0.0087
Leishmania major glutamine synthetase, putative 0.0118 0.034 0.0543
Schistosoma mansoni mixed-lineage leukemia protein mll 0.026 0.0825 0.0825
Mycobacterium tuberculosis Probable reductase 0.021 0.0656 0.1066
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0059 0.0159
Brugia malayi Pre-SET motif family protein 0.0063 0.0149 0.0236
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0072 0.0108
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0123 0.0357 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0072 0.0108
Trypanosoma cruzi glutamine synthetase, putative 0.0118 0.034 0.0543
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0427 0.0421
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0496 0.0496
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0059 0.0079
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0084 0.0121
Loa Loa (eye worm) Gln-2 protein 0.0076 0.0194 0.0311
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0059 0.0079
Brugia malayi Latrophilin receptor protein 2 0.0115 0.0326 0.0529
Brugia malayi Smad1 0.0041 0.0075 0.0114
Echinococcus multilocularis hexokinase 0.0183 0.0561 0.0555
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0044 0.0038
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.0326 0.0529
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0732 0.0726
Schistosoma mansoni hypothetical protein 0.0115 0.0326 0.0326
Schistosoma mansoni glutamine synthetase bacteria 0.003 0.0035 0.0035
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1784 0.6065 0.6063
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Brugia malayi intermediate filament protein 0.0027 0.0024 0.0029
Brugia malayi glutamine synthetase 0.0042 0.0078 0.0118
Brugia malayi nuclear hormone receptor 0.004 0.0072 0.0108
Trypanosoma brucei squalene synthase, putative 0.0556 0.1843 0.3027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0072 0.0066
Echinococcus multilocularis smad 0.0041 0.0075 0.0069
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0159 0.0253
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.0173 0.0528 0.0862
Schistosoma mansoni cpg binding protein 0.0121 0.035 0.035
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0059 0.0079
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0044 0.0055
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0072 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0261 0.0255
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0084 0.0078
Brugia malayi steroid hormone receptor 0.004 0.0072 0.0108
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1784 0.6065 1
Toxoplasma gondii hexokinase 0.0183 0.0561 0.0909
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0072 0.0072
Loa Loa (eye worm) beta-lactamase 0.0037 0.0059 0.0087
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0027 0.0027
Brugia malayi beta-lactamase family protein 0.0037 0.0059 0.0087
Loa Loa (eye worm) hypothetical protein 0.0058 0.0132 0.0208
Schistosoma mansoni hypothetical protein 0.0173 0.0528 0.0528
Toxoplasma gondii ABC1 family protein 0.0037 0.0059 0.0079
Brugia malayi MH1 domain containing protein 0.0023 0.0011 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0072 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.045 0.148 0.1475
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0173 0.0528 0.3225
Plasmodium vivax SET domain protein, putative 0.0063 0.0149 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Echinococcus multilocularis hexokinase type 2 0.0183 0.0561 0.0555
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0042 0.0052
Echinococcus multilocularis neuropeptide receptor A26 0.0519 0.1716 0.1711
Echinococcus multilocularis Smad4 0.0041 0.0075 0.0069
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0059 0.0079
Echinococcus multilocularis hexokinase 0.0183 0.0561 0.0555
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0149
Loa Loa (eye worm) hexokinase 0.0115 0.0327 0.0529
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.045 0.148 0.2427
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Mycobacterium ulcerans phytoene synthase, CrtB 0.0173 0.0528 0.0854
Brugia malayi isocitrate dehydrogenase 0.0032 0.0044 0.0063
Echinococcus granulosus tar DNA binding protein 0.0066 0.0159 0.0153
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.045 0.148 0.148
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0059 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0006 0.0006
Onchocerca volvulus 0.0183 0.0561 0.3435
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Brugia malayi Polyprenyl synthetase family protein 0.045 0.148 0.2433
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 0.4972
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0076 0.0194 0.0303
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0149 0.0143
Leishmania major hexokinase, putative 0.0183 0.0561 0.0909
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0044 0.0055
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0075 0.0114
Mycobacterium tuberculosis Probable oxidoreductase 0.0234 0.0737 0.1199
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.0656 0.1066
Trypanosoma brucei glutamine synthetase, putative 0.0118 0.034 0.0543
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.045 0.148 0.2427
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.045 0.148 0.4838
Schistosoma mansoni nuclear hormone receptor 0.004 0.0072 0.0072
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.045 0.148 0.1475
Brugia malayi hypothetical protein 0.0144 0.0427 0.0695
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0042 0.0052
Echinococcus granulosus hexokinase 0.0183 0.0561 0.0555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Mycobacterium tuberculosis Conserved protein 0.0037 0.0059 0.0079
Onchocerca volvulus 0.0115 0.0327 0.1938
Brugia malayi hypothetical protein 0.0119 0.0343 0.0555
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0052
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0084 0.0121
Treponema pallidum octaprenyl-diphosphate synthase 0.045 0.148 0.488
Echinococcus granulosus lamin 0.0027 0.0024 0.0018
Schistosoma mansoni hypothetical protein 0.0047 0.0096 0.0096
Schistosoma mansoni cpg binding protein 0.0128 0.0373 0.0373
Schistosoma mansoni smad1 5 8 and 0.0041 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1784 0.6065 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Onchocerca volvulus 0.0037 0.0059 0.0225
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0024 0.0029
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.025 0.0395
Brugia malayi Calcitonin receptor-like protein seb-1 0.0362 0.1177 0.1933
Echinococcus multilocularis musashi 0.0027 0.0024 0.0018
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.045 0.148 0.1475
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0059 0.0079
Echinococcus granulosus smad 0.0041 0.0075 0.0069
Leishmania major farnesyl pyrophosphate synthase 0.1784 0.6065 1
Trypanosoma cruzi hexokinase, putative 0.0183 0.0561 0.0909
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0042 0.0052
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0044 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0072 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0044 0.0038
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0059 0.0087
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0042 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0072 0.0066
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0042 0.0052
Schistosoma mansoni hypothetical protein 0.0115 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0311 0.1001 0.1642
Brugia malayi MH1 domain containing protein 0.0041 0.0075 0.0114
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0072 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0261 0.0255
Loa Loa (eye worm) hypothetical protein 0.0362 0.1177 0.1933
Onchocerca volvulus 0.0037 0.0059 0.0225
Echinococcus multilocularis lamin dm0 0.0027 0.0024 0.0018
Echinococcus multilocularis tumor protein p63 0.0328 0.1061 0.1056
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0059 0.0079
Echinococcus granulosus pyrroline 5 carboxylate reductase 0.0023 0.0011 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0042 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Treponema pallidum NADH oxidase 0.0032 0.0042 0.0105
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.2685 0.2681
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.0326 0.032
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1784 0.6065 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0132 0.0126
Loa Loa (eye worm) polyprenyl synthetase 0.045 0.148 0.2433
Trichomonas vaginalis set domain proteins, putative 0.0481 0.1588 0.2604
Brugia malayi Hexokinase family protein 0.0057 0.0127 0.02
Loa Loa (eye worm) transcription factor SMAD2 0.0609 0.2024 0.3331
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0149 0.0149
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0084 0.0121
Trypanosoma brucei trypanothione reductase 0.0092 0.025 0.0395
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0096 0.0148
Brugia malayi hypothetical protein 0.0233 0.0732 0.1198
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0118 0.034 0.034
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0075 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0072 0.0108
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0042 0.0052
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0044 0.0055
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0044 0.0044
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0084 0.0129
Onchocerca volvulus 0.0183 0.0561 0.3435
Onchocerca volvulus 0.0063 0.0149 0.0802
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0059 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Schistosoma mansoni glutathione synthetase 0.045 0.148 0.148
Echinococcus multilocularis geminin 0.0531 0.1757 0.1752
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.0326 0.032
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0068 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0072 0.0108
Schistosoma mansoni hexokinase 0.0183 0.0561 0.0561
Echinococcus multilocularis glutamine synthetase 0.0118 0.034 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Entamoeba histolytica hexokinase 2 0.0183 0.0561 0.3638
Echinococcus multilocularis Squalene phytoene synthase 0.0173 0.0528 0.0522
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0261 0.0261
Echinococcus granulosus neuropeptide receptor A26 0.0519 0.1716 0.1711
Schistosoma mansoni hypothetical protein 0.0115 0.0326 0.0326
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0044 0.0055
Trypanosoma cruzi hexokinase, putative 0.0183 0.0561 0.0909
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0159 0.0253
Plasmodium vivax glutathione reductase, putative 0.0092 0.025 0.0395
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0044 0.0063
Loa Loa (eye worm) hexokinase type II 0.0183 0.0561 0.0916
Loa Loa (eye worm) RNA binding protein 0.0066 0.0159 0.0253
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0234 0.0737 0.1199
Brugia malayi ecdysteroid receptor 0.004 0.0072 0.0108
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0072 0.0306
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0036
Echinococcus granulosus GPCR family 2 0.0115 0.0326 0.032
Loa Loa (eye worm) hypothetical protein 0.0125 0.0361 0.0586
Schistosoma mansoni hypothetical protein 0.0247 0.0783 0.0783
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0059 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0072 0.0108
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0072 0.0066
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0042 0.0052
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1784 0.6065 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0044 0.0038
Echinococcus granulosus Smad4 0.0041 0.0075 0.0069
Onchocerca volvulus Huntingtin homolog 0.012 0.0347 0.2065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0121 0.035 0.0567
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0036
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Plasmodium falciparum thioredoxin reductase 0.0092 0.025 0.0395
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0042
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0059 0.0079
Echinococcus multilocularis cpg binding protein 0.0128 0.0373 0.0368
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.003 0.0035 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.012 0.0347 0.0562
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1784 0.6065 1
Plasmodium falciparum thioredoxin reductase 0.0032 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Entamoeba histolytica hypothetical protein 0.0144 0.0427 0.2711
Echinococcus granulosus tumor protein p63 0.0328 0.1061 0.1056
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.025 0.0395
Brugia malayi Hexokinase family protein 0.0115 0.0327 0.0529
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.0069 0.0063
Mycobacterium ulcerans glutamine synthetase 0.0076 0.0194 0.0303
Plasmodium vivax glutamine synthetase, putative 0.0076 0.0194 0.0303
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0042 0.0052
Brugia malayi hexokinase 0.0183 0.0561 0.0916
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.045 0.148 0.2427
Loa Loa (eye worm) glutathione reductase 0.0092 0.025 0.0402
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.025 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0084 0.0121
Brugia malayi CXXC zinc finger family protein 0.0121 0.035 0.0567
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Onchocerca volvulus Huntingtin homolog 0.012 0.0347 0.2065
Trypanosoma cruzi phytoene synthase, putative 0.0173 0.0528 0.0854
Schistosoma mansoni hypothetical protein 0.0144 0.0427 0.0427
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.045 0.148 0.1475
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0234 0.0737 0.1199
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0149 0.0143
Echinococcus granulosus intermediate filament protein 0.0027 0.0024 0.0018
Echinococcus granulosus hexokinase 0.0183 0.0561 0.0555
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0075 0.0069
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.0656 0.1066
Brugia malayi MH2 domain containing protein 0.0041 0.0075 0.0114
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0084 0.0078
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.045 0.148 0.2427
Leishmania major solanesyl-diphosphate synthase, putative 0.045 0.148 0.2427
Echinococcus multilocularis dnaJ subfamily B 0.1728 0.5873 0.587
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0072 0.0072
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1784 0.6065 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0149
Trypanosoma cruzi polyprenyl synthase, putative 0.045 0.148 0.2427
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0084 0.0338
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.0656 0.1066
Brugia malayi RNA binding protein 0.0066 0.0159 0.0253
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Echinococcus granulosus cpg binding protein 0.0128 0.0373 0.0368
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.045 0.148 1
Plasmodium falciparum hexokinase 0.0183 0.0561 0.0909
Schistosoma mansoni hypothetical protein 0.0531 0.1757 0.1757
Schistosoma mansoni trans-prenyltransferase 0.045 0.148 0.148
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0072 0.0108
Echinococcus granulosus glutamine synthetase 0.0118 0.034 0.0334
Schistosoma mansoni smad1 5 8 and 0.0041 0.0075 0.0075
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.021 0.0656 0.2143
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.045 0.148 0.4838
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.045 0.148 0.2427
Trypanosoma brucei hexokinase 0.0183 0.0561 0.0909
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Entamoeba histolytica hypothetical protein 0.0144 0.0427 0.2711
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Brugia malayi beta-lactamase 0.0037 0.0059 0.0087
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0072 0.0072
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0044 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0072 0.0066
Entamoeba histolytica hypothetical protein 0.0144 0.0427 0.2711
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0027 0.0027
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0173 0.0528 0.0854
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0042 0.0052
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0075 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Leishmania major polyprenyl synthase, putative 0.045 0.148 0.2427
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0059 0.0079
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1784 0.6065 0.6063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Mycobacterium ulcerans hypothetical protein 0.003 0.0035 0.004
Toxoplasma gondii thioredoxin reductase 0.0092 0.025 0.0395
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0072 0.0072
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0059 0.0079
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0072 0.0306
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0042 0.0052
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1784 0.6065 1
Leishmania major hexokinase, putative 0.0183 0.0561 0.0909
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0128 0.0373 0.0373
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 0.4972
Onchocerca volvulus 0.0048 0.0098 0.0473
Brugia malayi follicle stimulating hormone receptor 0.0232 0.073 0.1194
Echinococcus granulosus dnaJ subfamily B 0.1728 0.5873 0.587
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0059 0.0079
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.045 0.148 0.488
Loa Loa (eye worm) hypothetical protein 0.0247 0.0783 0.1283
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0084 0.0121
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.045 0.148 0.1475
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0072 0.0108
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0044 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0072 0.0066
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0075 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Trichomonas vaginalis esterase, putative 0.0037 0.0059 0.0079
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0072 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0072 0.0108
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0042 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0261 0.0261
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1784 0.6065 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0059 0.0079
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1784 0.6065 1
Echinococcus granulosus hexokinase type 2 0.0183 0.0561 0.0555
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0059 0.0079
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.0656 0.1066
Brugia malayi MH2 domain containing protein 0.0041 0.0075 0.0114
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0072 0.0108
Trypanosoma cruzi polyprenyl synthase, putative 0.045 0.148 0.2427
Mycobacterium ulcerans lipase LipD 0.0037 0.0059 0.0079
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0044 0.0038
Brugia malayi MH2 domain containing protein 0.0609 0.2024 0.3331
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0059 0.0053
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0006 0.0006
Mycobacterium leprae Probable lipase LipE 0.0037 0.0059 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0072 0.0108
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.045 0.148 0.2433
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0159 0.0153
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.0326 0.0529
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.0069 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0496 0.0496
Brugia malayi Pre-SET motif family protein 0.0423 0.1388 0.2281
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0042 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0059 0.0079
Brugia malayi Thioredoxin reductase 0.0092 0.025 0.0402
Brugia malayi Hexokinase family protein 0.0183 0.0561 0.0916
Schistosoma mansoni hypothetical protein 0.0115 0.0326 0.0326
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0042 0.0052
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1784 0.6065 1
Echinococcus granulosus lamin dm0 0.0027 0.0024 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0044 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.0326 0.032
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0042 0.0052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0042 0.0052
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0072 0.0066
Echinococcus multilocularis hexokinase 0.0183 0.0561 0.0555
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0024 0.0029
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0098 0.0098
Schistosoma mansoni survival motor neuron protein 0.0047 0.0096 0.0096
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0899 0.3021 1
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.045 0.148 0.2427
Giardia lamblia Farnesyl diphosphate synthase 0.1784 0.6065 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0087
Echinococcus granulosus neuropeptide s receptor 0.0519 0.1716 0.1711
Brugia malayi TAR-binding protein 0.0066 0.0159 0.0253
Loa Loa (eye worm) hypothetical protein 0.0233 0.0732 0.1198
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1784 0.6065 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0044 0.0055
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0149 0.0228
Schistosoma mansoni smad1 5 8 and 0.0041 0.0075 0.0075
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0084 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0072 0.0108
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0072 0.0072
Entamoeba histolytica hexokinase 1 0.0183 0.0561 0.3638
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0234 0.0737 0.2411
Brugia malayi MH1 domain containing protein 0.0023 0.0011 0.0009
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0042 0.0052
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0059 0.0079
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.045 0.148 0.2427
Schistosoma mansoni microtubule-associated protein tau 0.2929 1 1
Onchocerca volvulus 0.0481 0.1588 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0072 0.0108
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0159 0.0253
Brugia malayi hexokinase type II 0.0058 0.0132 0.0208
Schistosoma mansoni intermediate filament proteins 0.0027 0.0024 0.0024
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0084 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0059 0.0079
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1784 0.6065 0.6065
Leishmania major trypanothione reductase 0.0092 0.025 0.0395
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0357 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0072 0.0108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0261 0.0255
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0059 0.0087
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0032 0.0044 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0261 0.0261
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0042 0.0052
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0075 0.0069
Loa Loa (eye worm) nuclear factor I 0.0023 0.0011 0.0009
Echinococcus granulosus geminin 0.0531 0.1757 0.1752
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0899 0.3021 1
Leishmania major hypothetical protein, conserved 0.0037 0.0059 0.0079
Toxoplasma gondii histone lysine methyltransferase SET1 0.0232 0.073 0.1188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0362 0.1177 0.1933
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.1388 0.2281
Plasmodium vivax hexokinase, putative 0.0183 0.0561 0.0909
Schistosoma mansoni glutamine synthetase bacteria 0.003 0.0035 0.0035
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0072 0.0072
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.045 0.148 0.1475
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Onchocerca volvulus Hexokinase homolog 0.0115 0.0327 0.1938
Onchocerca volvulus 0.0047 0.0096 0.046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0261 0.042
Trichomonas vaginalis glutamine synthetase, putative 0.003 0.0035 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0026
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.003 0.0035 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0027 0.0027
Trichomonas vaginalis helicase, putative 0.0027 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0072 0.0108
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0108
Echinococcus granulosus FTZ F1 alpha 0.004 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0098 0.0151
Loa Loa (eye worm) hypothetical protein 0.0058 0.0132 0.0208
Schistosoma mansoni coup transcription factor 0.004 0.0072 0.0072
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0072 0.0306
Trypanosoma cruzi glutamine synthetase, putative 0.0118 0.034 0.0543
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0052
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.025 0.0395
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0149 0.0143
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0013 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0261 0.042
Loa Loa (eye worm) hexokinase 0.0183 0.0561 0.0916
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0044 0.0055
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0042 0.0052
Loa Loa (eye worm) Smad1 0.0041 0.0075 0.0114
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0899 0.3021 0.4972
Schistosoma mansoni lamin 0.0027 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0149 0.0149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0261 0.0255
Loa Loa (eye worm) polyprenyl synthetase 0.1784 0.6065 1
Schistosoma mansoni lamin 0.0027 0.0024 0.0024
Loa Loa (eye worm) histone methyltransferase 0.004 0.0069 0.0104
Echinococcus multilocularis neuropeptide s receptor 0.0519 0.1716 0.1711
Brugia malayi hypothetical protein 0.012 0.0347 0.0562
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0059 0.0079
Trypanosoma cruzi solanesyl-diphosphate synthase 0.045 0.148 0.2427
Echinococcus granulosus mixed lineage leukemia protein mll 0.0032 0.0044 0.0038
Brugia malayi pyrroline-5-carboxylate reductase family protein 0.0023 0.0011 0.0008
Echinococcus multilocularis microtubule associated protein 2 0.2929 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0072 0.0108
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0075 0.0114
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0072 0.0072
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.025 0.0244
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0072 0.0066
Onchocerca volvulus 0.0183 0.0561 0.3435
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0042 0.0052
Schistosoma mansoni hypothetical protein 0.1728 0.5873 0.5873
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.073 0.1194
Loa Loa (eye worm) hexokinase 0.0057 0.0127 0.02
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0159 0.0159
Entamoeba histolytica hypothetical protein 0.0144 0.0427 0.2711
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.045 0.148 1
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1784 0.6065 1
Brugia malayi Polyprenyl synthetase family protein 0.1784 0.6065 1
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.045 0.148 0.4826
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0362 0.1177 0.1933
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0042 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0072 0.0108
Trypanosoma brucei hexokinase 0.0183 0.0561 0.0909
Onchocerca volvulus 0.004 0.0072 0.0306
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0732 0.0726
Trypanosoma cruzi squalene synthase, putative 0.0556 0.1843 0.3027
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0042 0.0024
Onchocerca volvulus 0.0121 0.035 0.2084
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0084 0.0078
Plasmodium falciparum glutathione reductase 0.0092 0.025 0.0395
Loa Loa (eye worm) hypothetical protein 0.0115 0.0326 0.0529
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0084 0.0084
Trypanosoma cruzi squalene synthase, putative 0.0556 0.1843 0.3027
Echinococcus multilocularis pyrroline 5 carboxylate reductase 0.0023 0.0011 0.0005
Echinococcus granulosus hexokinase 0.0183 0.0561 0.0555
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0357 0.0351
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0024 0.0029
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0216 0.0675 0.1098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0042 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0072 0.0108
Onchocerca volvulus Glutamine synthetase homolog 0.0076 0.0194 0.1091
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0427 0.0427
Toxoplasma gondii glutamine synthetase, type I, putative 0.0076 0.0194 0.0303
Echinococcus multilocularis GPCR, family 2 0.0115 0.0326 0.032
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.045 0.148 0.2433
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0084 0.0078
Echinococcus granulosus Squalene phytoene synthase 0.0173 0.0528 0.0522
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.045 0.148 0.2427
Schistosoma mansoni hypothetical protein 0.0531 0.1757 0.1757

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 687 % Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV at 30 uM by two-microelectrode voltage clamp technique relative to GABA ChEMBL. 21699169
EC50 (binding) = 54.3 uM Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique ChEMBL. 21699169
Smax (binding) = 2800 % Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique relative to GABA ChEMBL. 21699169

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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