Detailed information for compound 1108801

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 558.887 | Formula: C27H26Cl3N5O2
  • H donors: 3 H acceptors: 2 LogP: 6.63 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: ClCCN(c1ccc(cc1)NNC(=O)Nc1cc(nc2c1cc(Cl)cc2)c1cccc(c1)OC)CCCl
  • InChi: 1S/C27H26Cl3N5O2/c1-37-22-4-2-3-18(15-22)25-17-26(23-16-19(30)5-10-24(23)31-25)32-27(36)34-33-20-6-8-21(9-7-20)35(13-11-28)14-12-29/h2-10,15-17,33H,11-14H2,1H3,(H2,31,32,34,36)
  • InChiKey: SRPARZDQJKCUKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0097 0.9524
Brugia malayi AF-10 protein 0.0019 0.0012 0.0016
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0012 0.0057
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0011 0.0011
Brugia malayi hypothetical protein 0.0037 0.0052 0.0071
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0013 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0049 0.0487
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0009
Brugia malayi PHD-finger family protein 0.002 0.0015 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0611 0.6123
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0049 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0052 0.0509
Plasmodium falciparum replication factor C subunit 1, putative 0.0037 0.0052 0.5003
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0013 0.0045
Brugia malayi hypothetical protein 0.0037 0.0052 0.0071
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0011 0.0038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.0611 0.7753
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0011 0.0038
Trypanosoma cruzi sterol C-24 reductase, putative 0.0046 0.0073 0.0085
Brugia malayi beta-lactamase 0.0036 0.0049 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0013 0.0018
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0367 0.0783 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0013 0.0018
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Trypanosoma cruzi DNA repair protein, putative 0.0031 0.0038 0.0038
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0049 0.0487
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.2868 0.6317 0.9174
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0162
Schistosoma mansoni hypothetical protein 0.0152 0.0306 0.1037
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0373 0.0795 0.2692
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0319 0.3193
Brugia malayi ecdysteroid receptor 0.0028 0.0033 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0162
Trichomonas vaginalis replication factor C large subunit, putative 0.0037 0.0052 0.0509
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0013 0.0013
Onchocerca volvulus 0.0036 0.0049 0.0167
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0033 0.0112
Brugia malayi beta-lactamase family protein 0.0036 0.0049 0.0068
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0013 0.0018
Schistosoma mansoni microtubule-associated protein tau 0.065 0.141 0.4773
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0013 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0073 0.0101
Echinococcus granulosus Niemann Pick C1 protein 0.0524 0.1131 0.3829
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0611 0.6123
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0049 0.0068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0092 0.0175 0.0242
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0002 0.001
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0013 0.0013
Onchocerca volvulus 0.0019 0.0013 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0091 0.0309
Brugia malayi Patched related family protein 4 0.0022 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Brugia malayi beta-lactamase family protein 0.0036 0.0049 0.0068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0408 0.0873 0.121
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0013 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0019 0.001
Onchocerca volvulus 0.0022 0.002 0.0067
Plasmodium falciparum phd finger protein, putative 0.0057 0.0097 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0097 0.0327
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0049 0.0065
Leishmania major C-14 sterol reductase, putative 0.0089 0.0167 0.0217
Schistosoma mansoni tar DNA-binding protein 0.012 0.0236 0.0799
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0035 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0046
Mycobacterium leprae Conserved hypothetical protein 0.105 0.2295 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0008 0.007
Toxoplasma gondii ABC1 family protein 0.0036 0.0049 0.4252
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.0384 0.1299
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0029 0.0035 0.0119
Schistosoma mansoni coup transcription factor 0.0028 0.0033 0.0112
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Schistosoma mansoni chromobox protein 0.0067 0.0119 0.0404
Schistosoma mansoni hypothetical protein 0.0165 0.0336 0.1138
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0052 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0052 0.0509
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0008 0.007
Plasmodium vivax hypothetical protein, conserved 0.002 0.0015 0.0924
Schistosoma mansoni tar DNA-binding protein 0.012 0.0236 0.0799
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0097 0.0327
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Onchocerca volvulus 0.0022 0.002 0.0067
Brugia malayi CXXC zinc finger family protein 0.0026 0.0028 0.0038
Brugia malayi nuclear receptor NHR-88 0.0028 0.0033 0.0046
Schistosoma mansoni nAChR subunit 0.0019 0.0013 0.0045
Echinococcus multilocularis chromobox protein 1 0.0067 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0037 0.0052 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0033 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0101 0.0342
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0049 0.0053
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0049 0.0068
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0033 0.0112
Onchocerca volvulus Putative nachr subunit 0.0019 0.0013 0.0045
Echinococcus multilocularis lamin b receptor 0.0089 0.0167 0.0167
Chlamydia trachomatis replicative DNA helicase 0.0356 0.0759 1
Brugia malayi topoisomerase 0.0037 0.0052 0.0071
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0011 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0033 0.0033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0013 0.0018
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0037 0.0052 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0035 0.0049
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0046
Echinococcus granulosus lamin b receptor 0.0089 0.0167 0.0566
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0049 0.0065
Toxoplasma gondii patched family protein 0.0022 0.002 0.0948
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0019 0.0162
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Onchocerca volvulus 0.0037 0.0052 0.0174
Onchocerca volvulus 0.0268 0.0564 0.191
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0054 0.0533
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0119 0.119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0098 0.0187 0.0259
Onchocerca volvulus 0.0019 0.0013 0.0045
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0146 0.0495
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0054 0.0182
Onchocerca volvulus 0.0022 0.002 0.0067
Brugia malayi Patched related family protein 10 0.0022 0.002 0.0027
Echinococcus granulosus nibrin 0.0037 0.0052 0.0174
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0033 0.0112
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0013 0.0018
Brugia malayi TAR-binding protein 0.012 0.0236 0.0327
Plasmodium vivax patched family protein, putative 0.0022 0.002 0.1401
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0033 0.0046
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0033 0.0112
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0091 0.1128
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.0264 0.0892
Echinococcus multilocularis chromobox protein 1 0.0067 0.0119 0.0119
Brugia malayi jmjC domain containing protein 0.0018 0.0011 0.0015
Schistosoma mansoni tar DNA-binding protein 0.012 0.0236 0.0799
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0033 0.0046
Trichomonas vaginalis esterase, putative 0.0036 0.0049 0.0487
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0008 0.007
Echinococcus granulosus geminin 0.0165 0.0336 0.1138
Schistosoma mansoni cpg binding protein 0.0027 0.0031 0.0104
Loa Loa (eye worm) hypothetical protein 0.3271 0.7211 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0013 0.0045
Loa Loa (eye worm) hypothetical protein 0.0057 0.0097 0.0134
Loa Loa (eye worm) RNA binding protein 0.012 0.0236 0.0327
Loa Loa (eye worm) patched family protein 0.0022 0.002 0.0027
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0013 0.0018
Brugia malayi hypothetical protein 0.0015 0.0004 0.0005
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0052 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0052 0.0509
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Brugia malayi Niemann-Pick C1 protein precursor 0.0367 0.0783 0.1085
Brugia malayi Patched protein homolog 1 0.0022 0.002 0.0027
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Schistosoma mansoni topbp1 0.0037 0.0052 0.0174
Echinococcus multilocularis Niemann Pick C1 protein 0.0367 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0005
Trypanosoma cruzi sterol C-24 reductase, putative 0.0046 0.0073 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0033 0.0046
Schistosoma mansoni nAChR subunit 0.0019 0.0013 0.0045
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0014 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0033 0.0033
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0033 0.0112
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0013 0.0045
Mycobacterium ulcerans hypothetical protein 0.0036 0.0049 0.057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.012 0.0236 0.0327
Schistosoma mansoni jumonji domain containing protein 0.0148 0.0299 0.1012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0181 0.037 0.0514
Loa Loa (eye worm) hypothetical protein 0.0157 0.0319 0.0442
Echinococcus granulosus microtubule associated protein 2 0.065 0.141 0.4773
Toxoplasma gondii patched family protein 0.0022 0.002 0.0948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0157 0.0531
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0019 0.0162
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0019 0.0162
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0013 0.0018
Schistosoma mansoni Lamin B receptor (ERG24) 0.0089 0.0167 0.0566
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0013 0.0013
Trypanosoma cruzi C-14 sterol reductase, putative 0.0089 0.0167 0.0217
Schistosoma mansoni hypothetical protein 0.0152 0.0306 0.1037
Brugia malayi hypothetical protein 0.0066 0.0116 0.0161
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.0611 0.7908
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Echinococcus granulosus vesicular acetylcholine transporter 0.1348 0.2954 1
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0097 0.0134
Schistosoma mansoni nAChR subunit 0.0019 0.0013 0.0045
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0049 0.0167
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0013 0.0013
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0013 0.0013
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0037 0.0052 0.0145
Brugia malayi jmjC domain containing protein 0.0187 0.0384 0.0532
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0084 0.0157 0.0531
Onchocerca volvulus 0.0022 0.002 0.0067
Loa Loa (eye worm) beta-lactamase 0.0036 0.0049 0.0068
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0049 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0157 0.0531
Plasmodium vivax SET domain protein, putative 0.0059 0.0101 1
Loa Loa (eye worm) patched family protein 0.0022 0.002 0.0027
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0013 0.0045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0033 0.0112
Treponema pallidum recombinase A 0.0099 0.0191 0.1966
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.0214 0.0297
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0084 0.0157 0.0157
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0033 0.0112
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0015 0.0968
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0013 0.0018
Echinococcus multilocularis peregrin 0.0057 0.0097 0.0097
Schistosoma mansoni tar DNA-binding protein 0.012 0.0236 0.0799
Echinococcus granulosus expressed conserved protein 0.0345 0.0733 0.2483
Echinococcus multilocularis dnaJ subfamily B 0.0368 0.0785 0.0785
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0013 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0031 0.0104
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0019 0.0026
Echinococcus granulosus dnaJ subfamily B 0.0368 0.0785 0.2657
Brugia malayi Calcitonin receptor-like protein seb-1 0.0092 0.0175 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0033 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0033 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0033 0.0112
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0033 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0091 0.1128
Schistosoma mansoni chromobox protein 0.0067 0.0119 0.0404
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0013 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0049 0.0167
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0011 0.0011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0066 0.0116 0.0394
Brugia malayi hypothetical protein 0.0022 0.002 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0101 0.0101
Mycobacterium ulcerans recombinase A 0.0099 0.0191 0.2447
Loa Loa (eye worm) hypothetical protein 0.0886 0.1932 0.2679
Brugia malayi Bromodomain containing protein 0.0057 0.0097 0.0134
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0049 0.0065
Echinococcus granulosus tumor protein p63 0.0625 0.1355 0.4587
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0033 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0152 0.0306 0.1037
Mycobacterium ulcerans lipase LipD 0.0036 0.0049 0.057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0611 0.6123
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0016 0.0006 0.0003
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0011 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0101 0.0342
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.0063 0.011 0.0153
Leishmania major C-8 sterol isomerase-like protein 0.3271 0.7211 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0013 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0033 0.0046
Trypanosoma cruzi DNA repair protein, putative 0.0031 0.0038 0.0038
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0126 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0033 0.0046
Mycobacterium tuberculosis Conserved protein 0.0036 0.0049 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0046
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0049 0.0065
Schistosoma mansoni tar DNA-binding protein 0.012 0.0236 0.0799
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Echinococcus multilocularis synaptic vesicular amine transporter 0.038 0.0811 0.0811
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0268 0.0564 0.0768
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0013 0.0018
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0011 0.0038
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0091 0.0309
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0033 0.0033
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0162 0.033 0.1117
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0011 0.0015
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0013 0.0018
Onchocerca volvulus 0.0028 0.0033 0.0112
Mycobacterium leprae Probable lipase LipE 0.0036 0.0049 0.0135
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0046
Onchocerca volvulus 0.0019 0.0013 0.0045
Onchocerca volvulus 0.0019 0.0013 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0084 0.0157 0.0217
Leishmania major hypothetical protein, conserved 0.0268 0.0564 0.0768
Onchocerca volvulus Protein patched homolog 0.0022 0.002 0.0067
Brugia malayi CHE-14 protein 0.0157 0.0319 0.0442
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0028 0.0038
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0068
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0012 0.0001
Trypanosoma brucei C-14 sterol reductase, putative 0.0089 0.0167 0.0217
Echinococcus multilocularis serotonin receptor 0.0132 0.0264 0.0264
Echinococcus granulosus chromobox protein 1 0.0067 0.0119 0.0404
Brugia malayi MH2 domain containing protein 0.011 0.0214 0.0297
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0193 0.0397 0.0551
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0126 0.0428
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0083 0.806
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Onchocerca volvulus 0.0036 0.0049 0.0167
Echinococcus multilocularis survival motor neuron protein 1 0.0886 0.1932 0.1932
Loa Loa (eye worm) hypothetical protein 0.0063 0.011 0.0153
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0013 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Plasmodium vivax replication factor C subunit 1, putative 0.0037 0.0052 0.4777
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Schistosoma mansoni Replicative DNA helicase 0.0356 0.0759 0.2569
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0611 0.6123
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0037 0.0052 0.0056
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0431
Brugia malayi ERG2 and Sigma1 receptor like protein 0.3271 0.7211 1
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0033 0.0046
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0011 0.0038
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0097 0.9524
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0049 0.0487
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0091 0.0126
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0356 0.0759 1
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0031 0.0038 0.0038
Echinococcus multilocularis tumor protein p63 0.0625 0.1355 0.1355
Loa Loa (eye worm) hypothetical protein 0.0367 0.0783 0.1085
Schistosoma mansoni nAChR subunit 0.0019 0.0013 0.0045
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0013 0.0018
Entamoeba histolytica hypothetical protein 0.0066 0.0116 0.1279
Echinococcus multilocularis Niemann Pick C1 protein 0.0524 0.1131 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.003 0.0288
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0091 0.0309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0052 0.0071
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0037 0.0052 0.4501
Schistosoma mansoni nAChR subunit 0.0019 0.0013 0.0045
Trypanosoma cruzi C-14 sterol reductase, putative 0.0089 0.0167 0.0217
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0049
Schistosoma mansoni hypothetical protein 0.0029 0.0035 0.0119
Brugia malayi protein C24B5.3 0.0022 0.002 0.0027
Echinococcus granulosus phd:f box containing protein 0.0018 0.0011 0.0038
Schistosoma mansoni survival motor neuron protein 0.0181 0.037 0.1254
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0049 0.454
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0041 0.006 0.0597
Brugia malayi steroid hormone receptor 0.0028 0.0033 0.0046
Schistosoma mansoni hypothetical protein 0.0181 0.037 0.1254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0021
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.006 0.0204
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0049 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0049 0.0487
Brugia malayi hypothetical protein 0.0022 0.002 0.0027
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3124 0.6886 1
Brugia malayi Pre-SET motif family protein 0.0059 0.0101 0.014
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0034 0.0047
Echinococcus multilocularis replication factor c subunit 1 0.0037 0.0052 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0019 0.0021
Brugia malayi hypothetical protein 0.0022 0.002 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0049 0.0135
Onchocerca volvulus 0.0464 0.0997 0.3376
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0035 0.0119
Loa Loa (eye worm) hypothetical protein 0.0037 0.0052 0.0071
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1348 0.2954 1
Brugia malayi nuclear hormone receptor 0.0028 0.0033 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0096 0.0326
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0084 0.0157 0.0157
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0019 0.0026
Schistosoma mansoni topbp1 0.0037 0.0052 0.0174
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0033 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.005
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.038 0.0811 0.1125
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0013 0.0013
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0356 0.0759 1
Schistosoma mansoni hypothetical protein 0.0029 0.0035 0.0119
Schistosoma mansoni vesicular acetylcholine transporter 0.1348 0.2954 1
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0004 0.0012
Brugia malayi Cation transporter family protein 0.0019 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0157 0.0319 0.0442
Trichomonas vaginalis chromobox protein, putative 0.0041 0.006 0.0597
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Echinococcus multilocularis microtubule associated protein 2 0.065 0.141 0.141
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Schistosoma mansoni cpg binding protein 0.0026 0.0028 0.0093
Brugia malayi nuclear receptor RXR 0.0015 0.0004 0.0005
Echinococcus granulosus GPCR family 2 0.0029 0.0035 0.0119
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0033 0.0046
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0033 0.0112
Onchocerca volvulus 0.0019 0.0013 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Echinococcus multilocularis nAChR subunit 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0075
Giardia lamblia PHD finger protein 15 0.0057 0.0097 0.0806
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.003 0.0288
Loa Loa (eye worm) hypothetical protein 0.0037 0.0052 0.0071
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0119 0.119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0092 0.0175 0.0242
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0008 0.007
Schistosoma mansoni hypothetical protein 0.0057 0.0097 0.0327
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0066 0.0116 0.0116
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0013 0.0013
Schistosoma mansoni chromosome transmission fidelity factor 0.0037 0.0052 0.0175
Entamoeba histolytica hypothetical protein 0.0066 0.0116 0.1279
Schistosoma mansoni hypothetical protein 0.0019 0.0012 0.0039
Trypanosoma brucei Emopamil binding protein, putative 0.0268 0.0564 0.0768
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0013 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0008 0.007
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0033 0.0046
Mycobacterium tuberculosis Conserved protein 0.0036 0.0049 0.0065
Onchocerca volvulus 0.0036 0.0049 0.0167
Schistosoma mansoni nAChR subunit 0.0019 0.0013 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0019 0.001
Onchocerca volvulus 0.0022 0.002 0.0067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0009
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0013 0.0018
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0037 0.0052 0.0509
Echinococcus granulosus cpg binding protein 0.0027 0.0031 0.0104
Leishmania major sterol C-24 reductase, putative 0.0046 0.0073 0.0085
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0011 0.0038
Loa Loa (eye worm) patched family protein 0.0022 0.002 0.0027
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.0384 0.0384
Trypanosoma cruzi C-8 sterol isomerase, putative 0.3271 0.7211 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0037 0.0052 0.0509
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0033 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0052 0.0056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0019 0.0021
Echinococcus granulosus nAChR subunit 0.0019 0.0013 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0097 0.9548
Brugia malayi jmjC domain containing protein 0.0018 0.0011 0.0015
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0119 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0231 0.032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0091 0.1128
Echinococcus granulosus tm gpcr rhodopsin 0.0514 0.1108 0.3752
Brugia malayi Cation transporter family protein 0.0019 0.0013 0.0018
Mycobacterium ulcerans hypothetical protein 0.0022 0.0019 0.0162
Brugia malayi protein C24B5.3 0.0022 0.002 0.0027
Echinococcus multilocularis expressed conserved protein 0.0345 0.0733 0.0733
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0033 0.0046
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0046
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0013 0.0013
Echinococcus multilocularis vesicular acetylcholine transporter 0.1348 0.2954 0.2954
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Brugia malayi RNA binding protein 0.012 0.0236 0.0327
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0084 0.0157 0.0217
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0004 0.0005
Onchocerca volvulus 0.0022 0.002 0.0067
Onchocerca volvulus Alhambra homolog 0.0057 0.0097 0.0327
Brugia malayi Patched related family protein 12 0.0022 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Schistosoma mansoni vesicular amine transporter 0.038 0.0811 0.2747
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0035 0.0035
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0012 0.0057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0033 0.0112
Echinococcus multilocularis protein dispatched 1 0.018 0.0368 0.0368
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0037 0.0052 0.0056
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0283 0.368
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0049 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0008 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0033 0.0112
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0009
Chlamydia trachomatis DNA ligase 0.0037 0.0052 0.06
Echinococcus granulosus tar DNA binding protein 0.012 0.0236 0.0799
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0033 0.0112
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0049 0.0487
Onchocerca volvulus 0.0022 0.0019 0.0063
Loa Loa (eye worm) hypothetical protein 0.0162 0.033 0.0457
Schistosoma mansoni cellular tumor antigen P53 0.0092 0.0173 0.0586
Brugia malayi Heterochromatin protein 1 0.0067 0.0119 0.0166
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0033 0.0046
Echinococcus multilocularis sterol regulatory element binding protein 0.0157 0.0319 0.0319
Schistosoma mansoni cpg binding protein 0.0027 0.0031 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0009
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0011 0.0524
Echinococcus multilocularis cpg binding protein 0.0027 0.0031 0.0031
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0013 0.0045
Toxoplasma gondii hypothetical protein 0.0022 0.002 0.0948
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0011 0.0038
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0013 0.0018
Echinococcus granulosus peregrin 0.0057 0.0097 0.0327
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1348 0.2954 0.4096
Toxoplasma gondii patched family protein 0.0022 0.002 0.0948
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0283 0.0405
Brugia malayi Cation transporter family protein 0.0019 0.0013 0.0018
Chlamydia trachomatis recombinase RecA 0.0099 0.0191 0.2447
Echinococcus granulosus synaptic vesicular amine transporter 0.038 0.0811 0.2747
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0033 0.0046
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0146 0.0146
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.0611 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0011 0.0015
Brugia malayi hypothetical protein 0.0015 0.0004 0.0005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0126 0.0428
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0013 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0033 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0611 0.6123
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0037 0.0052 0.0509
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0037 0.0052 0.06
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0033 0.0046
Onchocerca volvulus 0.0092 0.0173 0.0586
Schistosoma mansoni nAChR subunit 0.0019 0.0013 0.0045
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0004 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0091 0.893
Brugia malayi Abnormal catecholamine distribution protein 1 0.038 0.0811 0.1125
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0011 0.0011
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0013 0.0045
Brugia malayi DKFZp564C0469 protein 0.0037 0.0052 0.0071
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0268 0.0564 0.0768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0059 0.0101 0.014
Loa Loa (eye worm) hypothetical protein 0.1672 0.3671 0.5091
Loa Loa (eye worm) hypothetical protein 0.0092 0.0173 0.024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0005
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0013 0.0045
Brugia malayi Pax transcription activation domain interacting protein 0.0037 0.0052 0.0071
Echinococcus granulosus Protein patched homolog 1 0.0157 0.0319 0.108
Treponema pallidum replicative DNA helicase (dnaB) 0.0356 0.0759 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0049 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0052 0.0056
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0049 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Schistosoma mansoni hypothetical protein 0.0066 0.0116 0.0394
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0611 0.6123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0008 0.007
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0013 0.0018
Echinococcus multilocularis geminin 0.0165 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Entamoeba histolytica hypothetical protein 0.0066 0.0116 0.1279
Echinococcus granulosus replication factor c subunit 1 0.0037 0.0052 0.0175
Schistosoma mansoni hypothetical protein 0.0029 0.0035 0.0119
Loa Loa (eye worm) hypothetical protein 0.0092 0.0175 0.0242
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0035 0.0035
Brugia malayi jmjC domain containing protein 0.0018 0.0011 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.0125 0.0424
Toxoplasma gondii ATPase, AAA family protein 0.0037 0.0052 0.4502
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0611 0.6123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0008 0.007
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0013 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0033 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0033 0.0033
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0099 0.0191 0.1966
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0019 0.0162
Echinococcus granulosus survival motor neuron protein 1 0.0886 0.1932 0.6541
Brugia malayi hypothetical protein 0.0886 0.1932 0.2679
Brugia malayi SET domain containing protein 0.0014 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0101 0.0342
Echinococcus granulosus sterol regulatory element binding protein 0.0157 0.0319 0.108
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0101 0.0342
Echinococcus granulosus chromobox protein 1 0.0067 0.0119 0.0404
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0033 0.0046
Plasmodium falciparum lipid/sterol:H+ symporter 0.0022 0.002 0.1467
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0475 0.0683
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Loa Loa (eye worm) patched family protein 0.0022 0.002 0.0027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0101 1
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0033 0.0112
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Brugia malayi jmjC domain containing protein 0.0071 0.0126 0.0175
Echinococcus multilocularis tar DNA binding protein 0.012 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0368 0.0785 0.2657
Brugia malayi vesicular acetylcholine transporter unc-17 0.1348 0.2954 0.4096
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0013 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0033 0.0046
Loa Loa (eye worm) patched family protein 0.0022 0.002 0.0027
Onchocerca volvulus 0.0022 0.002 0.0067
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0013 0.0045
Schistosoma mansoni hypothetical protein 0.0165 0.0336 0.1138
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0514 0.1108 0.1108
Toxoplasma gondii patched family protein 0.0022 0.002 0.0948
Brugia malayi jmjC domain containing protein 0.0018 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0052 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0002 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0033 0.0112
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Mycobacterium ulcerans beta-lactamase 0.0036 0.0049 0.057
Trypanosoma cruzi FHA domain containing protein, putative 0.0037 0.0052 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0157 0.0531
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0356 0.0759 0.3252
Loa Loa (eye worm) transcription factor SMAD2 0.011 0.0214 0.0297
Brugia malayi Pre-SET motif family protein 0.0408 0.0873 0.121
Loa Loa (eye worm) hypothetical protein 0.0132 0.0264 0.0366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Echinococcus multilocularis nibrin 0.0037 0.0052 0.0052
Schistosoma mansoni patched 1 0.0157 0.0319 0.108
Trichomonas vaginalis set domain proteins, putative 0.0464 0.0997 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0084 0.0157 0.0531
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0033 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0611 0.6123
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0152 0.0306 0.1037
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0049 0.0053
Echinococcus granulosus Niemann Pick C1 protein 0.0367 0.0783 0.2649
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0052 0.0509
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0013 0.0018
Brugia malayi Myosin head containing protein 0.0022 0.002 0.0027
Echinococcus multilocularis serotonin receptor 0.0132 0.0264 0.0264
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0013 0.0045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0033 0.0112
Plasmodium vivax JmjC domain containing protein 0.0018 0.0011 0.0501
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0013 0.0045
Onchocerca volvulus 0.0181 0.037 0.1254
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0013 0.0018
Mycobacterium tuberculosis Conserved protein 0.0036 0.0049 0.0065
Trypanosoma cruzi Emopamil binding protein, putative 0.0268 0.0564 0.0768
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0014 0.0014
Brugia malayi hypothetical protein 0.0022 0.002 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0033 0.0112
Brugia malayi PHD-finger family protein 0.0057 0.0097 0.0134
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0033 0.0046
Echinococcus multilocularis GPCR, family 2 0.0029 0.0035 0.0035
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0099 0.0191 0.0755
Onchocerca volvulus 0.007 0.0125 0.0424
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0012 0.0001
Loa Loa (eye worm) hypothetical protein 0.0132 0.0264 0.0366
Trypanosoma cruzi Emopamil binding protein, putative 0.0268 0.0564 0.0768
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0013 0.0018
Schistosoma mansoni transcription factor LCR-F1 0.0066 0.0116 0.0394
Brugia malayi RNA recognition motif domain containing protein 0.012 0.0236 0.0327
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Brugia malayi N-terminal motif family protein 0.0162 0.033 0.0457
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.0264 0.0892
Schistosoma mansoni DNA ligase IV 0.0037 0.0052 0.0174
Onchocerca volvulus 0.0026 0.0028 0.0093
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.0611 0.7753
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0049 0.0049
Brugia malayi chromobox protein homolog 3 0.0038 0.0054 0.0075
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0013 0.0018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0018
Entamoeba histolytica hypothetical protein 0.0066 0.0116 0.1279
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0091 0.0111
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0013 0.0045
Schistosoma mansoni hypothetical protein 0.0063 0.011 0.0372
Leishmania major hypothetical protein, conserved 0.0036 0.0049 0.0053
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0126 0.0175
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0013 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0033 0.0112
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0033 0.0112
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0013 0.0013
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0283 0.1163
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0033 0.0112
Echinococcus multilocularis protein patched 0.0157 0.0319 0.0319
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0037 0.0052 0.0431
Onchocerca volvulus 0.0019 0.0013 0.0045
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0049 0.0065
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0268 0.0564 0.0768
Brugia malayi Patched family protein 0.0022 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0033 0.0033
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0013 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0054 0.0533
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0037 0.0052 0.0509
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Trypanosoma brucei C-8 sterol isomerase, putative 0.3271 0.7211 1
Onchocerca volvulus Protein patched homolog 0.0022 0.002 0.0067
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0035 0.0049
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0033 0.0112
Onchocerca volvulus 0.003 0.0036 0.0121
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0095 0.0321
Loa Loa (eye worm) TAR-binding protein 0.012 0.0236 0.0327
Loa Loa (eye worm) twinkle helicase 0.0102 0.0196 0.0271
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0035 0.0119

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.732 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 20181487
IC50 (functional) = 2.133 uM Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 20181487
IC50 (functional) = 2.253 uM Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 20181487
IC50 (functional) = 13.888 uM Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay ChEMBL. 20181487
IC50 (functional) = 14.587 uM Cytotoxicity against human MX1 cells after 72 hrs by SRB assay ChEMBL. 20181487

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20181487

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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