Detailed information for compound 1140946

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 593.619 | Formula: C29H39NO12
  • H donors: 7 H acceptors: 9 LogP: -0.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(O[C@@H]1C(C)CCC2(C31OC1(C4(C3(O)C([C@]2(C1)C)(O)[C@@H](C4(O)C(C)C)OC(=O)c1[nH]ccc1)C)O)O)CCC(=O)O
  • InChi: 1S/C29H39NO12/c1-14(2)26(37)21(41-20(34)16-7-6-12-30-16)27(38)22(4)13-25(36)23(26,5)29(27,39)28(42-25)19(15(3)10-11-24(22,28)35)40-18(33)9-8-17(31)32/h6-7,12,14-15,19,21,30,35-39H,8-11,13H2,1-5H3,(H,31,32)/t15?,19-,21-,22+,23?,24?,25?,26?,27?,28?,29?/m1/s1
  • InChiKey: CHFBHBONOVYZBO-JFHFAMTHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Ryanodine receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Ryanodine Receptor TM 4-6 family protein Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma japonicum ko:K04963 ryanodine receptor 3 (brain), putative Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) ryanodine receptor Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) ryanodine receptor Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus granulosus ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma japonicum ko:K05327 ryanodine receptor, invertebrate, putative Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus multilocularis ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma japonicum Ryanodine receptor 3, putative Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus multilocularis ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus granulosus ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma mansoni ryanodine receptor related Get druggable targets OG5_129275 All targets in OG5_129275
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0053 0.0171 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0259 0.0344
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0171 0.0171
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0082 0.0069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0171 0.0171
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0171 0.0171
Echinococcus granulosus zinc finger protein 0.004 0.0091 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0404 0.055
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.017 0.0262
Plasmodium falciparum importin beta, putative 0.0057 0.02 0.6107
Echinococcus granulosus importin subunit beta 1 0.0057 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0086 0.0376 0.0582
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0404 0.0625
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0171 0.0171
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus granulosus gamma secretase subunit aph 1 0.0251 0.1381 0.1381
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0067 0.0259 0.0344
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0171 0.0232
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.02 0.0252
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0053 0.0171 0.0264
Schistosoma mansoni immunophilin 0.0045 0.0125 0.0171
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0516 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.017 0.0262
Echinococcus granulosus dro:myosuppressin receptor 0.0053 0.0171 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0059 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0516 1
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0133 0.1182
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0259 0.4078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Schistosoma mansoni hypothetical protein 0.0238 0.1306 0.1778
Schistosoma mansoni hypothetical protein 0.011 0.0523 0.0712
Schistosoma mansoni opsin-like receptor 0.0053 0.0171 0.0232
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0056 0.0193 0.0262
Onchocerca volvulus 0.0053 0.0171 0.0014
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0053 0.0171 0.0232
Schistosoma mansoni adenoreceptor 0.0053 0.0171 0.0232
Echinococcus granulosus orexin receptor type 2 0.0053 0.0171 0.0171
Brugia malayi RNA, U transporter 1 0.0164 0.0848 0.1311
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.007 0.007
Echinococcus granulosus ryanodine receptor 44f 0.0116 0.056 0.056
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0349 0.1981 0.3062
Loa Loa (eye worm) MBCTL1 0.011 0.0521 0.0805
Onchocerca volvulus 0.0109 0.0516 0.1205
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0053 0.0171 0.0171
Brugia malayi G-protein coupled receptor 0.0053 0.0171 0.0264
Plasmodium falciparum cysteine repeat modular protein 1 0.0052 0.0167 0.3926
Loa Loa (eye worm) hypothetical protein 0.011 0.0523 0.0808
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0059 0.0059
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0516 0.0516
Schistosoma mansoni zinc finger protein 0.004 0.0091 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0059 0.0081
Schistosoma mansoni amine GPCR 0.0053 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0052 0.0167 0.0258
Plasmodium vivax importin-beta 2, putative 0.0057 0.02 0.2269
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0082 0.0635
Echinococcus multilocularis G protein coupled receptor 139 0.0053 0.0171 0.0171
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0171 0.0264
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0053 0.0171 0.0232
Leishmania major GTP-binding protein, putative 0.0042 0.0107 0.0108
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0239 0.0239
Brugia malayi Kringle domain containing protein 0.0052 0.0167 0.0258
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus granulosus snurportin 1 0.0614 0.3602 0.3602
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0239 0.0326
Mycobacterium tuberculosis Conserved protein 0.0109 0.0516 0.113
Loa Loa (eye worm) hypothetical protein 0.0109 0.0516 0.0798
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi hypothetical protein 0.009 0.0396 0.0611
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0217 0.1177 0.7405
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.011 0.0523 0.0523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Echinococcus multilocularis serotonin receptor 0.0172 0.0903 0.0903
Echinococcus multilocularis zinc finger protein 0.004 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0192 0.1021 0.1578
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.017 0.0205
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0067 0.0259 0.0593
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.017 0.0205
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0066 0.0255 0.0337
Echinococcus multilocularis somatostatin receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni neuropeptide receptor 0.0053 0.0171 0.0232
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0217 0.1177 0.1771
Onchocerca volvulus 0.0053 0.0171 0.0014
Schistosoma mansoni myelin transcription factor 1 myt1 0.011 0.0521 0.0709
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0111 0.0525 0.0758
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0111 0.0525 0.0714
Schistosoma mansoni ryanodine receptor related 0.0184 0.0975 0.1327
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.017 0.0205
Schistosoma mansoni chromatin regulatory protein sir2 0.0052 0.0163 0.0222
Brugia malayi RE15519p 0.0053 0.0171 0.0264
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0171 0.0232
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0171 0.0232
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0614 0.3602 0.5567
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0244 0.0332
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0053 0.0171 0.0264
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0217 0.1177 0.1771
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1083 0.647 1
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0171 0.0171
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0167 0.0201
Mycobacterium ulcerans NAD-dependent deacetylase 0.0052 0.0163 0.0549
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) ryanodine receptor 0.0069 0.0269 0.0416
Loa Loa (eye worm) hypothetical protein 0.1083 0.647 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.0588 0.0588
Brugia malayi prolyl oligopeptidase family protein 0.0067 0.0259 0.04
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Echinococcus granulosus histone acetyltransferase MYST2 0.011 0.0521 0.0521
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.017 0.017
Brugia malayi Serotonin receptor 0.0053 0.0171 0.0264
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.011 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0067 0.0259 0.04
Echinococcus granulosus 7TM GPCR rhodopsin 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0109 0.0516 0.0798
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0097 0.0439 0.0939
Loa Loa (eye worm) hypothetical protein 0.0043 0.0114 0.0176
Trypanosoma cruzi oligopeptidase b 0.0217 0.1177 0.1771
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni zinc finger protein 0.0031 0.0038 0.0051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0244 0.1095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0349 0.1981 0.3062
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0053 0.0171 0.0264
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0516 0.113
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0171 0.0264
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.017 0.0205
Schistosoma mansoni ran 0.0042 0.0107 0.0146
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Loa Loa (eye worm) beta-lactamase 0.0109 0.0516 0.0798
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0053 0.0171 0.0232
Trichomonas vaginalis immunophilin, putative 0.0053 0.017 0.2021
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0111 0.0525 0.0758
Schistosoma mansoni eyes absent homolog 0.009 0.0396 0.0538
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0516 0.113
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0165 0.3811
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0052 0.0163 0.0195
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0526 0.3065 0.4172
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0171 0.0171
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.017 0.0205
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0165 0.0198
Mycobacterium tuberculosis Conserved protein 0.0109 0.0516 0.113
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1083 0.647 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0174 0.0269
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0516 0.2936
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Schistosoma mansoni ran 0.0042 0.0107 0.0146
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.0439 0.0597
Leishmania major fk506-binding protein 1-like protein 0.0053 0.017 0.0205
Loa Loa (eye worm) hypothetical protein 0.0143 0.0724 0.1119
Onchocerca volvulus 0.0097 0.0439 0.0939
Brugia malayi prolyl oligopeptidase family protein 0.0111 0.0525 0.0811
Trichomonas vaginalis ran, putative 0.0042 0.0107 0.0576
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0276 0.1538 0.2377
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0459 0.2654 0.64
Brugia malayi ORL1-like opioid receptor 0.0053 0.0171 0.0264
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0217 0.1177 0.1771
Echinococcus multilocularis GPCR, family 2 0.011 0.0523 0.0523
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0516 0.0702
Brugia malayi mbt repeat family protein 0.0097 0.0439 0.0678
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0526 0.3065 0.4172
Schistosoma mansoni hypothetical protein 0.0587 0.3439 0.4681
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0165 0.0198
Loa Loa (eye worm) hypothetical protein 0.0052 0.0165 0.0255
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0244 0.1095
Onchocerca volvulus 0.0053 0.0171 0.0014
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni immunophilin 0.0053 0.017 0.0231
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.017 0.2021
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0053 0.0171 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0239 0.0326
Echinococcus granulosus Dipeptidyl peptidase 9 0.0111 0.0525 0.0525
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0293 0.0293
Brugia malayi Trypsin family protein 0.0192 0.1021 0.1578
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0107 0.0107
Echinococcus granulosus sex peptide receptor 0.0053 0.0171 0.0171
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0223 0.1212 0.1649
Echinococcus multilocularis neuropeptide s receptor 0.0053 0.0171 0.0171
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Loa Loa (eye worm) hypothetical protein 0.011 0.0521 0.0805
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.011 0.0521 0.0521
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0082 0.0069
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0052 0.0163 0.0195
Echinococcus multilocularis gamma secretase subunit aph 1 0.0251 0.1381 0.1381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0053 0.0171 0.0264
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0516 0.2936
Schistosoma mansoni hypothetical protein 0.011 0.0523 0.0712
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Echinococcus granulosus tar DNA binding protein 0.0064 0.0239 0.0239
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0111 0.0525 0.1485
Trypanosoma cruzi prolyl endopeptidase 0.0526 0.3065 0.4706
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.017 0.017
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0107 0.0108
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.007 0.0095
Brugia malayi cation channel family protein 0.0079 0.033 0.051
Brugia malayi Serotonin receptor 0.0053 0.0171 0.0264
Loa Loa (eye worm) hypothetical protein 0.0082 0.0353 0.0545
Mycobacterium leprae Probable lipase LipE 0.0109 0.0516 0.4097
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0082 0.0082
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0133 0.1182
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0125 0.0125
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0127 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0516 1
Loa Loa (eye worm) transcription factor SMAD2 0.0364 0.2077 0.3209
Toxoplasma gondii ABC1 family protein 0.0109 0.0516 0.1455
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0217 0.1177 0.2759
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni amine GPCR 0.0053 0.0171 0.0232
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.017 0.2021
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus granulosus tachykinin peptides receptor 99D 0.0053 0.0171 0.0171
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0053 0.0171 0.0232
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0111 0.0525 0.0758
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0111 0.0525 0.0758
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni growth hormone secretagogue receptor 0.0053 0.0171 0.0232
Schistosoma mansoni biogenic amine (5HT) receptor 0.0172 0.0903 0.1229
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0111 0.0525 0.0525
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0217 0.1177 0.1771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0404 0.055
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0259 0.0344
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0171 0.0171
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0244 0.0244
Schistosoma mansoni gamma-secretase subunit aph-1 0.0251 0.1381 0.1879
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0184 0.0975 0.1507
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.011 0.0521 0.0805
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0053 0.0171 0.0264
Echinococcus granulosus g protein coupled receptor 0.0053 0.0171 0.0171
Brugia malayi follicle stimulating hormone receptor 0.0276 0.1538 0.2377
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Onchocerca volvulus 0.0053 0.0171 0.0014
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.0167 0.0258
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0053 0.0171 0.0014
Echinococcus multilocularis SAM and MBT domain containing protein 0.0097 0.0439 0.0439
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.017 0.4125
Loa Loa (eye worm) prolyl oligopeptidase 0.0223 0.1212 0.1873
Brugia malayi Protein kinase domain containing protein 0.0052 0.0167 0.0258
Leishmania major hypothetical protein, conserved 0.0109 0.0516 0.0744
Onchocerca volvulus 0.0053 0.0171 0.0014
Schistosoma mansoni neuropeptide receptor 0.0053 0.0171 0.0232
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0516 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0107 0.0165
Plasmodium vivax NAD-dependent deacetylase, putative 0.0052 0.0163 0.1375
Schistosoma mansoni biogenic amine receptor 0.0053 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0097
Schistosoma mansoni opsin-like receptor 0.0053 0.0171 0.0232
Entamoeba histolytica hypothetical protein 0.0047 0.0133 0.335
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0516 0.113
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.017 0.4125
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0217 0.1177 1
Mycobacterium ulcerans hypothetical protein 0.0109 0.0516 0.2936
Echinococcus granulosus g protein coupled receptor 0.0053 0.0171 0.0171
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0052 0.0163 0.37
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0516 0.113
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0516 0.4097
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0239 0.0326
Brugia malayi hypothetical protein 0.0052 0.0165 0.0255
Loa Loa (eye worm) hypothetical protein 0.0109 0.0516 0.0798
Schistosoma mansoni hypothetical protein 0.0614 0.3602 0.4902
Schistosoma mansoni hypothetical protein 0.0517 0.3011 0.4098
Brugia malayi beta-lactamase family protein 0.0109 0.0516 0.0798
Brugia malayi Inositol-1 0.0038 0.0082 0.0127
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.007 0.007
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0053 0.0171 0.0171
Echinococcus multilocularis g-protein coupled receptor 0.0053 0.0171 0.0171
Schistosoma mansoni immunophilin 0.0053 0.017 0.0231
Echinococcus granulosus fmrfamide receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0107 0.0165
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Echinococcus multilocularis prolyl endopeptidase 0.0526 0.3065 0.3065
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0052 0.0163 0.0261
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0171 0.0171
Brugia malayi Latrophilin receptor protein 2 0.011 0.0523 0.0808
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0067 0.0259 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0053 0.0171 0.0014
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0053 0.0171 0.0232
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0516 0.0744
Brugia malayi sulfakinin receptor protein 0.0053 0.0171 0.0264
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0259 0.3716
Brugia malayi Dopamine receptor 0.0053 0.0171 0.0264
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0082 0.0069
Loa Loa (eye worm) prolyl oligopeptidase 0.0067 0.0259 0.04
Brugia malayi Dopamine receptor protein 1 0.0053 0.0171 0.0264
Brugia malayi prolyl oligopeptidase family protein 0.0223 0.1212 0.1873
Onchocerca volvulus 0.0053 0.0171 0.0014
Trichomonas vaginalis esterase, putative 0.0109 0.0516 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0223 0.1212 0.1212
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0516 0.0798
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.0171 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0404 0.0404
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0239 0.037
Echinococcus granulosus neuropeptide FF receptor 2 0.0053 0.0171 0.0171
Entamoeba histolytica Ran family GTPase 0.0042 0.0107 0.1957
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0404 0.055
Echinococcus granulosus SAM and MBT domain containing protein 0.0097 0.0439 0.0439
Echinococcus granulosus g-protein coupled receptor 0.0053 0.0171 0.0171
Echinococcus multilocularis neuropeptide receptor A26 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0097 0.0439 0.0678
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0171 0.0171
Mycobacterium ulcerans lipase LipD 0.0109 0.0516 0.2936
Echinococcus granulosus hypothetical protein 0.0053 0.0171 0.0171
Echinococcus granulosus peptide allatostatin:somatostatin 0.0053 0.0171 0.0171
Entamoeba histolytica prolyl oligopeptidase family protein 0.0067 0.0259 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0171 0.0171
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0067 0.0259 0.0353
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0192 0.1021 0.1389
Trypanosoma brucei prolyl oligopeptidase, putative 0.0217 0.1177 0.1771
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.011 0.0523 0.0808
Echinococcus granulosus 7tm_1 domain containing protein 0.0053 0.0171 0.0171
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.166 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0107 0.0108
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0165 0.3811
Schistosoma mansoni inositol monophosphatase 0.0038 0.0082 0.0112
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0107 0.0084
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Plasmodium falciparum peptidase, putative 0.0067 0.0259 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0381 0.2176 0.2176
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0109 0.0516 0.0798
Trypanosoma brucei prolyl endopeptidase 0.0526 0.3065 0.4706
Schistosoma mansoni neuropeptide f receptor 76f 0.0053 0.0171 0.0232
Schistosoma mansoni myosin xvIII 0.0053 0.0171 0.0232
Brugia malayi Tachykinin-like peptides receptor 99D 0.0053 0.0171 0.0264
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0104 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.017 0.4125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0404 0.0404
Echinococcus multilocularis histone acetyltransferase MYST2 0.011 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0526 0.3065 0.4737
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0053 0.0171 0.0171
Onchocerca volvulus 0.0053 0.0171 0.0014
Onchocerca volvulus 0.0053 0.0171 0.0014
Onchocerca volvulus 0.0053 0.0171 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0238 0.1306 0.2019
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0165 0.1416
Leishmania major hypothetical protein, conserved 0.0052 0.0165 0.0198
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0244 0.0244
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.017 0.1533
Leishmania major oligopeptidase b 0.0217 0.1177 0.1771
Loa Loa (eye worm) hypothetical protein 0.0078 0.0323 0.05
Onchocerca volvulus 0.0172 0.0903 0.254
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0516 0.0744
Onchocerca volvulus 0.0109 0.0516 0.1205
Schistosoma mansoni amine GPCR 0.0378 0.2163 0.2943
Giardia lamblia Transcriptional regulator, Sir2 family 0.0052 0.0163 0.37
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0053 0.0171 0.0171
Echinococcus granulosus serotonin receptor 0.0053 0.0171 0.0171
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0133 0.1182
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0053 0.0171 0.0264
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0223 0.1212 0.3606
Brugia malayi TAR-binding protein 0.0064 0.0239 0.037
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0516 0.113
Loa Loa (eye worm) FKBP5 protein 0.0053 0.017 0.0262
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0404 0.0625
Leishmania major importin beta-1 subunit, putative 0.0047 0.0133 0.0149
Brugia malayi hypothetical protein 0.0033 0.0053 0.0081
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Mycobacterium ulcerans beta-lactamase 0.0109 0.0516 0.2936
Brugia malayi AKH receptor 0.0053 0.0171 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0404 0.0404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0404 0.0404
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0163 0.1872
Schistosoma mansoni alpha-1 adrenergic receptor 0.0053 0.0171 0.0232
Entamoeba histolytica hypothetical protein, conserved 0.0067 0.0259 1
Echinococcus multilocularis geminin 0.0517 0.3011 0.3011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0239 0.037
Loa Loa (eye worm) hypothetical protein 0.0172 0.0903 0.1396
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0171 0.0264
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.017 0.0205
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0171 0.0232
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0516 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0059 0.0081
Schistosoma mansoni hypothetical protein 0.0053 0.0171 0.0232
Entamoeba histolytica prolyl oligopeptidase family protein 0.0067 0.0259 1
Trypanosoma cruzi oligopeptidase b 0.0217 0.1177 0.1771
Loa Loa (eye worm) melatonin receptor type 1A 0.0053 0.0171 0.0264
Schistosoma mansoni biogenic amine receptor 0.0053 0.0171 0.0232
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) TYRA-2 protein 0.0053 0.0171 0.0264
Echinococcus granulosus alpha 1A adrenergic receptor 0.0053 0.0171 0.0171
Brugia malayi beta-lactamase family protein 0.0109 0.0516 0.0798
Schistosoma mansoni histamine h1 receptor 0.0053 0.0171 0.0232
Brugia malayi MH2 domain containing protein 0.0364 0.2077 0.3209
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0381 0.2176 0.2176
Echinococcus granulosus allatostatin A receptor 0.0053 0.0171 0.0171
Echinococcus multilocularis tissue type plasminogen activator 0.0052 0.0167 0.0167
Echinococcus granulosus acylamino acid releasing enzyme 0.0067 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0053 0.0171 0.0232
Toxoplasma gondii hypothetical protein 0.0067 0.0259 0.0593
Echinococcus multilocularis sex peptide receptor 0.0053 0.0171 0.0171
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0192 0.1021 0.1389
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Brugia malayi prolyl oligopeptidase family protein 0.0526 0.3065 0.4737
Onchocerca volvulus 0.0053 0.0171 0.0014
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0053 0.0171 0.0232
Brugia malayi neuropeptide F receptor 0.0053 0.0171 0.0264
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0059 0.0059
Loa Loa (eye worm) RNA binding protein 0.0064 0.0239 0.037
Schistosoma mansoni biogenic amine receptor 0.0053 0.0171 0.0232
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0171 0.0171
Trypanosoma brucei Aph-1 protein, putative 0.0098 0.0445 0.0634
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0133 0.0149
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0067 0.0259 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.0903 0.1396
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0223 0.1212 0.1212
Brugia malayi G protein-coupled receptor F59B2.13 0.0053 0.0171 0.0264
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0059 0.0081
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.011 0.0521 0.0521
Schistosoma mansoni amine GPCR 0.0053 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0516 0.113
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.0259 0.4078
Brugia malayi G protein-coupled receptor 0.0053 0.0171 0.0264
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0238 0.1306 0.2019
Echinococcus multilocularis ryanodine receptor 44f 0.0116 0.056 0.056
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.0588 0.0588
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0526 0.3065 0.4706
Brugia malayi gamma-secretase subunit aph-1 0.0251 0.1381 0.2134
Brugia malayi Bromodomain containing protein 0.0078 0.0322 0.0498
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0244 0.0459
Echinococcus granulosus prolyl endopeptidase 0.0526 0.3065 0.3065
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi larval opioid receptor 0.0053 0.0171 0.0264
Trypanosoma brucei oligopeptidase b 0.0217 0.1177 0.1771
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus multilocularis G-protein coupled receptor, putative 0.0053 0.0171 0.0171
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0165 0.0278
Loa Loa (eye worm) mbt repeat family protein 0.0097 0.0439 0.0678
Entamoeba histolytica prolyl oligopeptidase family protein 0.0067 0.0259 1
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0516 0.113
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0239 0.0326
Mycobacterium tuberculosis Probable peptidase 0.0217 0.1177 0.2759
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0067 0.0259 0.4078
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0171 0.0171
Echinococcus granulosus geminin 0.0517 0.3011 0.3011
Loa Loa (eye worm) hypothetical protein 0.0045 0.0125 0.0194
Echinococcus granulosus ryanodine receptor 44f 0.0149 0.0761 0.0761
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0059 0.0059
Brugia malayi Importin beta-1 subunit 0.0057 0.02 0.0309
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0244 0.0321
Echinococcus granulosus biogenic amine 5HT receptor 0.0172 0.0903 0.0903
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.0309
Echinococcus multilocularis ryanodine receptor 44f 0.0149 0.0761 0.0761
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0171 0.0171
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Onchocerca volvulus 0.0192 0.1021 0.2947
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.02 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.017 0.5
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0163 0.1872
Loa Loa (eye worm) hypothetical protein 0.009 0.0396 0.0611
Echinococcus multilocularis allatostatin A receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0067 0.0259 0.04
Onchocerca volvulus 0.0053 0.0171 0.0014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0053 0.0171 0.0264
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi Melatonin receptor type 1A 0.0053 0.0171 0.0264
Echinococcus granulosus neuropeptide receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0109 0.0516 0.0798
Toxoplasma gondii prolyl endopeptidase 0.0526 0.3065 1
Brugia malayi hypothetical protein 0.0036 0.007 0.0108
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0052 0.0167 0.1459
Schistosoma mansoni amine GPCR 0.0053 0.0171 0.0232
Schistosoma mansoni hypothetical protein 0.0036 0.007 0.0095
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0553 0.3233 0.4996
Onchocerca volvulus 0.0053 0.0171 0.0014
Schistosoma mansoni inositol monophosphatase 0.0038 0.0082 0.0112
Leishmania major hypothetical protein, conserved 0.0052 0.0167 0.0201
Echinococcus granulosus G protein coupled receptor 139 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0053 0.0171 0.0171
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0516 0.0702
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0052 0.0163 0.0195
Echinococcus multilocularis neuropeptide FF receptor 2 0.0053 0.0171 0.0171
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0244 0.0377
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0516 0.0798
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0349 0.1981 0.3062
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.017 0.0593
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0125 0.0125
Echinococcus multilocularis serotonin receptor 0.0172 0.0903 0.0903
Brugia malayi Bromodomain containing protein 0.0152 0.0777 0.1201
Brugia malayi putative neuropeptide receptor 0.0053 0.0171 0.0264
Trypanosoma cruzi Aph-1 protein, putative 0.0098 0.0445 0.0634
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) ryanodine receptor 0.0043 0.0114 0.0176
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Onchocerca volvulus 0.0053 0.0171 0.0014
Schistosoma mansoni hypothetical protein 0.0517 0.3011 0.4098
Brugia malayi GnHR receptor homolog 0.0053 0.0171 0.0264
Toxoplasma gondii kringle domain-containing protein 0.0052 0.0167 0.0284
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0163 0.1872
Echinococcus granulosus neuropeptide receptor 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0192 0.1021 0.1578
Echinococcus multilocularis orexin receptor type 2 0.0053 0.0171 0.0171
Schistosoma mansoni neuropeptide receptor 0.0053 0.0171 0.0232
Echinococcus multilocularis fk506 binding protein 0.0053 0.017 0.017
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0059 0.0059
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0052 0.0163 0.0195
Brugia malayi putative neuropeptide receptor NPR1 0.0053 0.0171 0.0264
Leishmania major hypothetical protein, conserved 0.0045 0.0124 0.0135
Schistosoma mansoni sex comb on midleg homolog 0.0097 0.0439 0.0597
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0171 0.0171
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0067 0.0259 0.0353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0516 0.0744
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0053 0.0171 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Brugia malayi Dopamine receptor protein 2 0.0053 0.0171 0.0264
Echinococcus multilocularis polycomb protein SCMH1 0.0097 0.0439 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0251 0.1381 0.2134
Brugia malayi PHD-finger family protein 0.005 0.0157 0.0242
Echinococcus multilocularis acylamino acid releasing enzyme 0.0067 0.0259 0.0259
Loa Loa (eye worm) inositol-1 0.0038 0.0082 0.0127
Schistosoma mansoni bromodomain containing protein 0.0128 0.0632 0.086
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0052 0.0163 0.4933
Brugia malayi RNA binding protein 0.0064 0.0239 0.037
Loa Loa (eye worm) latrophilin receptor protein 2 0.011 0.0523 0.0808
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0053 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0107 0.0108
Loa Loa (eye worm) hypothetical protein 0.0116 0.056 0.0866
Leishmania major C-8 sterol isomerase-like protein 0.1083 0.647 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0082 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0349 0.1981 0.3062
Echinococcus granulosus tissue type plasminogen activator 0.0052 0.0167 0.0167
Trypanosoma brucei C-8 sterol isomerase, putative 0.1083 0.647 1
Echinococcus granulosus GPCR family 2 0.011 0.0523 0.0523
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0171 0.0171
Schistosoma mansoni importin beta-1 0.0057 0.02 0.0272
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0035 0.0063 0.0047
Schistosoma mansoni hypothetical protein 0.011 0.0523 0.0712
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0082 0.0069
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0067 0.0103
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.0171 0.0171
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0171 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0239 0.0326
Mycobacterium tuberculosis Probable oxidoreductase 0.028 0.1561 0.3704
Onchocerca volvulus Prolyl endopeptidase homolog 0.0526 0.3065 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0111 0.0525 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0109 0.0516 0.0798
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0698 0.4115 1
Brugia malayi G-protein coupled receptor 0.0053 0.0171 0.0264
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.017 0.0262
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0171 0.0171
Echinococcus granulosus neuropeptide s receptor 0.0053 0.0171 0.0171
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0127 0.0127
Echinococcus granulosus polycomb protein SCMH1 0.0097 0.0439 0.0439
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0223 0.1212 0.1649
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.017 0.017
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0171 0.0171
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0165 0.0198
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0053 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.011 0.0523 0.0712
Brugia malayi beta-lactamase 0.0109 0.0516 0.0798
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0097 0.0439 0.0597
Onchocerca volvulus 0.0109 0.0516 0.1205
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0053 0.0171 0.0232
Echinococcus multilocularis snurportin 1 0.0614 0.3602 0.3602
Giardia lamblia Alanyl dipeptidyl peptidase 0.0067 0.0259 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Echinococcus multilocularis dro:myosuppressin receptor 0.0053 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Onchocerca volvulus 0.0053 0.0171 0.0014
Giardia lamblia Alanyl dipeptidyl peptidase 0.0067 0.0259 1
Mycobacterium tuberculosis Conserved protein 0.0109 0.0516 0.113
Mycobacterium ulcerans short chain dehydrogenase 0.028 0.1561 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0293 0.0293
Schistosoma mansoni hypothetical protein 0.0045 0.0126 0.0172
Onchocerca volvulus 0.0053 0.0171 0.0014
Echinococcus granulosus g protein coupled receptor 0.0053 0.0171 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0516 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Brugia malayi prolyl oligopeptidase family protein 0.0067 0.0259 0.04
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0171 0.0232
Brugia malayi mbt repeat family protein 0.0097 0.0439 0.0678
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.011 0.0523 0.0523
Echinococcus granulosus neuropeptide receptor A26 0.0053 0.0171 0.0171
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0171 0.0171
Echinococcus multilocularis importin subunit beta 1 0.0057 0.02 0.02
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.02 0.0395
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1226 0.7347 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.017 0.0231
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0171 0.0264
Toxoplasma gondii histone deacetylase SIR2 0.0052 0.0163 0.0272
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.017 0.5275
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0059 0.0092
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.017 0.2021
Schistosoma mansoni hypothetical protein 0.0042 0.0104 0.0141
Schistosoma mansoni opsin-like receptor 0.0053 0.0171 0.0232
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0053 0.0171 0.0171
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.011 0.0523 0.0523
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0171 0.0171
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.017 0.5275
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0264
Schistosoma mansoni hypothetical protein 0.0053 0.0171 0.0232
Brugia malayi neuropeptide F receptor 0.0053 0.0171 0.0264
Onchocerca volvulus 0.0053 0.0171 0.0014
Trypanosoma cruzi Aph-1 protein, putative 0.0098 0.0445 0.0634
Schistosoma mansoni hypothetical protein 0.0053 0.0171 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.0364 0.2077 0.3209
Brugia malayi hypothetical protein 0.0043 0.0114 0.0176
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0171 0.0232
Brugia malayi hypothetical protein 0.0053 0.0171 0.0264
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.017 0.0205
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0053 0.0171 0.0264
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0127 0.0173
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0239 0.037
Schistosoma mansoni neuropeptide receptor 0.0053 0.0171 0.0232
Schistosoma mansoni hypothetical protein 0.0052 0.0167 0.0227
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0066 0.0255 0.0337
Loa Loa (eye worm) hypothetical protein 0.009 0.0396 0.0611
Echinococcus granulosus somatostatin receptor 0.0053 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.0031 0.0038 0.0051

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1000 nM Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesicles ChEMBL. 8388466

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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