Detailed information for compound 1155582

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 638.696 | Formula: C23H26N8O8S3
  • H donors: 5 H acceptors: 8 LogP: 1.01 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(N)nc([n+]1C)SCC1=C(C(=O)[O-])N2C(SC1)C(C2=O)NC(=O)/C(=N\OC(C(=O)O)(C)C)/c1cnc(s1)N
  • InChi: 1S/C23H26N8O8S3/c1-23(2,20(36)37)39-29-13(10-6-26-21(25)42-10)16(32)28-14-17(33)31-15(19(34)35)9(7-40-18(14)31)8-41-22-27-11(24)5-12(38-4)30(22)3/h5-6,14,18,24H,7-8H2,1-4H3,(H5,25,26,28,29,32,34,35,36,37)
  • InChiKey: KAJFLQMNLKTMMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Metacaspase-4 0.0027 0.0078 0.0056
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0398 0.049
Plasmodium vivax SET domain protein, putative 0.0029 0.0096 0.1216
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.0182 0.0208
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0087 0.0084
Plasmodium vivax sulfate transporter, putative 0.0033 0.0121 0.162
Echinococcus multilocularis neurogenic locus notch protein 4 0.0151 0.096 0.1224
Echinococcus granulosus delta-like protein 1 0.0151 0.096 0.1224
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0045 0.021 0.0516
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0087 0.0087
Onchocerca volvulus Chorion peroxidase homolog 0.0978 0.6847 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0087 0.0103
Schistosoma mansoni ap endonuclease 0.0021 0.0035 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0099
Schistosoma mansoni carbonic anhydrase-related 0.053 0.3658 0.4246
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0078 0.0056
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0122
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.004 0.0176 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.0182 0.0208
Schistosoma mansoni coup transcription factor 0.0028 0.0087 0.0087
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0045 0.021 0.0275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0096 0.0098
Loa Loa (eye worm) hypothetical protein 0.0089 0.0519 0.0658
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0231
Echinococcus granulosus neurogenic locus notch protein 0.0151 0.096 0.1224
Echinococcus granulosus voltage dependent calcium channel 0.004 0.0176 0.02
Onchocerca volvulus Peroxidase homolog 0.0978 0.6847 1
Brugia malayi Calcium binding EGF domain containing protein 0.0151 0.096 0.124
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0087 0.0103
Schistosoma mansoni cell polarity protein 0.0151 0.096 0.1104
Brugia malayi Cathepsin L-like precursor 0.0019 0.0022 0.0019
Brugia malayi Cathepsin L-like precursor 0.0019 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0243 0.1615 0.2049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Schistosoma mansoni slit 0.0151 0.096 0.1104
Brugia malayi Cadherin domain containing protein 0.0151 0.096 0.124
Loa Loa (eye worm) voltage-dependent calcium channel 0.004 0.0176 0.0223
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0096 0.0096
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0087 0.0084
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Trichomonas vaginalis protein phosphatase PP2A regulatory subunit B, putative 0.0085 0.0496 0.0474
Brugia malayi endoprotease bli-4 precursor 0.004 0.0173 0.0215
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0121 0.0086
Schistosoma mansoni laminin gamma-3 chain 0.0151 0.096 0.1104
Trichomonas vaginalis serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative 0.0085 0.0496 0.0474
Mycobacterium ulcerans hypothetical protein 0.004 0.0177 0.0142
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0096 0.0096
Brugia malayi neuroendocrine convertase 1 precursor 0.0025 0.0067 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.1422 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0035 0.0015
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0787 0.0998
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0329 0.0369
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0414 0.0511
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0223
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Brugia malayi EGF-like domain containing protein 0.0151 0.096 0.124
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0398 0.049
Schistosoma mansoni cytochrome c oxidase subunit II 0.0122 0.0759 0.087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0087 0.0103
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0087 0.0087
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0151 0.096 0.124
Schistosoma mansoni ap endonuclease 0.0021 0.0035 0.0027
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0029 0.0115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0024 0.0061 0.0039
Echinococcus multilocularis protein phosphatase pp2a regulatory subunit b 0.0085 0.0496 0.0617
Brugia malayi proprotein convertase 2 0.0025 0.0067 0.0077
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0194 0.1271 0.1613
Trypanosoma brucei metacaspase MCA3 0.0027 0.0078 0.0056
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0029 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0087 0.0087
Brugia malayi Cathepsin L-like precursor 0.0019 0.0022 0.0019
Schistosoma mansoni notch 0.0151 0.096 0.1104
Entamoeba histolytica ankyrin, putative 0.0071 0.0391 0.043
Onchocerca volvulus 0.0045 0.021 0.0275
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Brugia malayi hypothetical protein 0.0041 0.0182 0.0227
Echinococcus granulosus tar DNA binding protein 0.0062 0.0329 0.04
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0035 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0089 0.0086
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0182 0.0197
Echinococcus multilocularis notch 0.0151 0.096 0.1224
Schistosoma mansoni notch 0.0151 0.096 0.1104
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0035 0.0016
Schistosoma mansoni carbonic anhydrase 0.053 0.3658 0.4246
Loa Loa (eye worm) fibroinase 0.0019 0.0022 0.0028
Echinococcus granulosus mitogen activated protein kinase 11 0.0128 0.0801 0.1015
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0027 0.0082 0.0103
Brugia malayi EGF-like domain containing protein 0.0151 0.096 0.124
Loa Loa (eye worm) calcium channel 0.004 0.0176 0.0223
Echinococcus granulosus neurogenic locus notch protein 0.0151 0.096 0.1224
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0087 0.0087
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0045 0.021 0.0176
Plasmodium falciparum transporter, putative 0.0041 0.0182 0.0438
Mycobacterium leprae PROBABLE TRANSFERASE 0.0068 0.0372 0.0341
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0164 0.1055 0.1501
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0035 0.0208
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Schistosoma mansoni notch 0.0151 0.0961 0.1106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0231
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Onchocerca volvulus Neurogenic locus notch homolog 0.0151 0.0961 0.1376
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0022 0.0012
Plasmodium falciparum amino acid transporter, putative 0.0041 0.0182 0.0438
Loa Loa (eye worm) endoprotease bli-4 0.004 0.0173 0.0219
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0731 0.0924
Schistosoma mansoni notch 0.0151 0.096 0.1104
Trichomonas vaginalis AGC family protein kinase 0.0194 0.1271 0.1252
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0182 0.0197
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0231
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0052 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0231
Brugia malayi phosphoinositide-dependent protein kinase I 0.0194 0.1271 0.1645
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0986 0.1134
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0398 0.049
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0078 0.0077
Schistosoma mansoni polycystin 1-related 0.002 0.0029 0.002
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0029 0.0019
Leishmania major cathepsin L-like protease 0.0072 0.0398 0.0438
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0329 0.0369
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.004 0.0176 0.0184
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0028
Schistosoma mansoni cytochrome-c oxidase 0.0045 0.021 0.0231
Schistosoma mansoni peroxidasin 0.0978 0.6847 0.7962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Plasmodium vivax amine transporter, putative 0.0041 0.0182 0.262
Onchocerca volvulus Peroxidasin homolog 0.0978 0.6847 1
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0986 0.1134
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0087 0.011
Giardia lamblia Protein phosphatase PP2A regulatory subunit B 0.0085 0.0496 0.4978
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0087 0.0087
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0354 0.0433
Leishmania major carbonic anhydrase-like protein 0.1097 0.7688 0.894
Schistosoma mansoni microsomal glutathione s-transferase 0.0112 0.0687 0.0787
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Onchocerca volvulus 0.0062 0.0329 0.045
Brugia malayi P38 map kinase family protein 2 0.0128 0.0801 0.1033
Schistosoma mansoni hypothetical protein 0.053 0.3658 0.4246
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0121 0.0129
Echinococcus multilocularis protein jagged 1 0.0151 0.096 0.1224
Loa Loa (eye worm) hypothetical protein 0.0243 0.1615 0.2049
Echinococcus multilocularis neurogenic locus notch protein 0.0151 0.096 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0078 0.0056
Echinococcus granulosus peroxidasin 0.0978 0.6847 0.8903
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0128 0.0801 0.1015
Loa Loa (eye worm) animal heme peroxidase 0.0978 0.6847 0.869
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0087 0.0084
Echinococcus granulosus slit 2 protein 0.0151 0.096 0.1224
Plasmodium falciparum carbonic anhydrase 0.053 0.3658 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0035 0.0013
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0731 0.0924
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.004 0.0177 0.018
Trypanosoma brucei metacaspase MCA2 0.0027 0.0078 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0177 0.0201
Schistosoma mansoni carbonic anhydrase 0.1224 0.8597 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0087 0.011
Onchocerca volvulus Dual oxidase homolog 0.0978 0.6847 1
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0045 0.021 0.0257
Schistosoma mansoni notch 0.0151 0.096 0.1104
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0078 0.0056
Brugia malayi hypothetical protein 0.002 0.0029 0.0028
Leishmania major protein phosphatase 2A regulatory subunit, putative 0.0085 0.0496 0.0552
Echinococcus multilocularis carbonic anhydrase II 0.1097 0.7688 1
Brugia malayi Animal haem peroxidase family protein 0.0978 0.6847 0.8906
Trypanosoma cruzi metacaspase, putative 0.0027 0.0078 0.0073
Echinococcus granulosus carbonic anhydrase 0.053 0.3658 0.4742
Schistosoma mansoni sodium/chloride dependent transporter 0.0043 0.0198 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0087 0.0103
Echinococcus multilocularis apoptotic protease activating factor 1 0.0062 0.0329 0.0401
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0096 0.0203
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0087 0.0084
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.011
Brugia malayi RNA binding protein 0.0062 0.0329 0.0419
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0237 0.1573 0.2262
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.011
Echinococcus granulosus voltage dependent calcium channel 0.004 0.0176 0.02
Mycobacterium ulcerans epoxide hydrolase EphA 0.0164 0.1055 0.1024
Echinococcus multilocularis fat cadherin tumor suppressor 0.0151 0.096 0.1224
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1097 0.7688 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0024 0.0061 0.0051
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0087 0.0087
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.0182 0.0231
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0177 0.0201
Echinococcus granulosus apoptotic protease activating factor 1 0.0062 0.0329 0.0401
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0087 0.0095
Loa Loa (eye worm) hypothetical protein 0.1124 0.788 1
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0104 0.063 1
Toxoplasma gondii hypothetical protein 0.0036 0.0141 0.0327
Schistosoma mansoni hypothetical protein 0.002 0.0029 0.002
Echinococcus multilocularis neuroendocrine convertase 2 0.0025 0.0067 0.0058
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.053 0.3658 0.4752
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0087 0.0087
Schistosoma mansoni caspase-3 (C14 family) 0.0027 0.0078 0.0077
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0041 0.0182 0.0208
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.0182 0.0197
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0045 0.021 0.0516
Plasmodium vivax metacaspase 1, putative 0.0027 0.0078 0.0915
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0414 0.0511
Leishmania major metacaspase, putative 0.0027 0.0078 0.0065
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0035 0.0044
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0087 0.0084
Onchocerca volvulus 0.0068 0.0372 0.0512
Loa Loa (eye worm) hypothetical protein 0.053 0.3658 0.4642
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0041 0.0182 0.0227
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0182 0.0227
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0087 0.0084
Schistosoma mansoni lipoxygenase 0.0118 0.0731 0.0837
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0035 0.0016
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Echinococcus multilocularis peroxidasin 0.0978 0.6847 0.8903
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0045 0.021 0.0275
Loa Loa (eye worm) doublecortin family protein 0.002 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.011
Onchocerca volvulus 0.0028 0.0087 0.0095
Echinococcus granulosus protein jagged 2 0.0151 0.096 0.1224
Onchocerca volvulus Slit protein homolog 0.0151 0.096 0.1374
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0194 0.1271 0.1629
Plasmodium falciparum metacaspase 1 0.0027 0.0078 0.0153
Brugia malayi Calcium binding EGF domain containing protein 0.0151 0.096 0.124
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.0496 0.0617
Brugia malayi GCC2 and GCC3 family protein 0.0151 0.096 0.124
Brugia malayi EGF-like domain containing protein 0.0151 0.096 0.124
Toxoplasma gondii exonuclease III APE 0.0021 0.0035 0.0035
Echinococcus granulosus neuroendocrine convertase 2 0.0025 0.0067 0.0058
Leishmania major carbonic anhydrase family protein, putative 0.1224 0.8597 1
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0029 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0179
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0027 0.0078 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0087 0.011
Schistosoma mansoni loxhd1 0.002 0.0029 0.002
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1097 0.7688 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0087 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0087 0.0103
Mycobacterium leprae Probable transmembrane transport protein 0.0237 0.1573 0.1751
Schistosoma mansoni notch 0.0151 0.096 0.1104
Trypanosoma brucei carbonic anhydrase-like protein 0.1097 0.7688 1
Toxoplasma gondii hypothetical protein 0.0041 0.0182 0.0438
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0024 0.0061 0.0051
Leishmania major cytochrome p450-like protein 0.0023 0.0052 0.0034
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0022 0.0012
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0045 0.021 0.3087
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0231
Brugia malayi Cytochrome P450 family protein 0.0052 0.0259 0.0327
Brugia malayi Peroxidasin 0.0978 0.6847 0.8906
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0087 0.0103
Loa Loa (eye worm) animal heme peroxidase 0.0978 0.6847 0.869
Onchocerca volvulus Peroxidasin homolog 0.0978 0.6847 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0085 0.0497 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0087 0.0103
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Echinococcus granulosus carbonic anhydrase 0.053 0.3658 0.4742
Onchocerca volvulus 0.0978 0.6847 1
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0052 0.0066
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1097 0.7688 0.8941
Schistosoma mansoni carbonic anhydrase-related 0.053 0.3658 0.4246
Brugia malayi Cytochrome P450 family protein 0.0023 0.0052 0.0057
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Echinococcus multilocularis carbonic anhydrase 0.053 0.3658 0.4742
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0182 0.0438
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0029 0.0009
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Brugia malayi hypothetical protein 0.002 0.0029 0.0028
Brugia malayi Cathepsin L-like precursor 0.0019 0.0022 0.0019
Brugia malayi Blistered cuticle protein 3 0.0978 0.6847 0.8906
Trichomonas vaginalis protein phosphatase pp2a regulatory subunit B, putative 0.0085 0.0496 0.0474
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0029 0.0009
Trypanosoma cruzi metacaspase, putative 0.0027 0.0078 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0078 0.0915
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0078 0.0153
Entamoeba histolytica protein kinase, putative 0.0194 0.1271 0.1456
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0087 0.0103
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0329 0.0418
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0182 0.262
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0128 0.0801 0.1015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0016
Toxoplasma gondii EGF family domain-containing protein 0.0151 0.096 0.258
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.053 0.3658 0.4752
Schistosoma mansoni lipoxygenase 0.0083 0.0477 0.0542
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0087 0.0084
Onchocerca volvulus 0.0151 0.096 0.1374
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0035 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0329 0.0369
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0087 0.0103
Loa Loa (eye worm) hypothetical protein 0.0062 0.0329 0.0418
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0149 0.0952 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.011
Schistosoma mansoni hypothetical protein 0.0151 0.096 0.1104
Brugia malayi Animal haem peroxidase family protein 0.0978 0.6847 0.8906
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.004 0.0176 0.02
Onchocerca volvulus 0.0151 0.096 0.1374
Onchocerca volvulus 0.0151 0.096 0.1374
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1097 0.7688 0.9756
Brugia malayi ecdysteroid receptor 0.0028 0.0087 0.0103
Brugia malayi Pre-SET motif family protein 0.0029 0.0096 0.0115
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0087 0.0103
Brugia malayi Animal haem peroxidase family protein 0.0978 0.6847 0.8906
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.053 0.3658 0.4752
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0329 0.04
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Echinococcus granulosus protein phosphatase pp2a regulatory subunit b 0.0085 0.0496 0.0617
Echinococcus multilocularis caspase 2 0.0089 0.0519 0.0648
Giardia lamblia High cysteine protein 0.0151 0.096 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0128 0.0801 0.1015
Schistosoma mansoni hypothetical protein 0.0062 0.0329 0.037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0022 0.0028
Loa Loa (eye worm) ctsf protein 0.0019 0.0022 0.0028
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0682 0.474 0.692
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0151 0.096 0.1374
Brugia malayi steroid hormone receptor 0.0028 0.0087 0.0103
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0087 0.0084
Brugia malayi Pre-SET motif family protein 0.0204 0.1336 0.173
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0078 0.0077
Onchocerca volvulus 0.0243 0.1615 0.2333
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0068 0.0372 0.035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0087 0.0084
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0329 0.0418
Onchocerca volvulus 0.0041 0.0182 0.0233
Mycobacterium tuberculosis Possible siderophore-binding protein 0.004 0.0177 0.0208
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0052 0.0066
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0041 0.0182 0.0208
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.0182 0.0208
Echinococcus multilocularis neurogenic locus notch protein 0.0151 0.096 0.1224
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0037
Echinococcus multilocularis neurogenic locus protein delta 0.0151 0.096 0.1224
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1097 0.7688 1
Loa Loa (eye worm) serotonin transporter b 0.0243 0.1615 0.2049
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0052 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0096 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Schistosoma mansoni hypothetical protein 0.0151 0.096 0.1104
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0151 0.096 0.1104
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0078 0.0153
Entamoeba histolytica acetyltransferase, putative 0.0071 0.0391 0.0429
Brugia malayi EGF-like domain containing protein 0.0151 0.096 0.124
Echinococcus multilocularis RUN 0.002 0.0029 0.0009
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0121 0.0086
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0078 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0087 0.0084
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Schistosoma mansoni caspase-7 (C14 family) 0.0089 0.0519 0.059
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0087 0.0095
Brugia malayi Cell death protein 3 precursor 0.0089 0.0519 0.0666
Echinococcus granulosus caspase 2 0.0089 0.0519 0.0648
Onchocerca volvulus 0.0978 0.6847 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0243 0.1615 0.1867
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0096 0.0098
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Loa Loa (eye worm) notch protein 0.0151 0.096 0.1219
Entamoeba histolytica carbonic anhydrase, putative 0.1224 0.8597 1
Schistosoma mansoni hypothetical protein 0.0151 0.096 0.1104
Brugia malayi Cadherin domain containing protein 0.0151 0.096 0.124
Loa Loa (eye worm) animal heme peroxidase 0.0978 0.6847 0.869
Onchocerca volvulus 0.0232 0.1537 0.222
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0182 0.0197
Mycobacterium ulcerans carbonic anhydrase 0.1224 0.8597 0.8592
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0087 0.0084
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0078 0.0153
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Echinococcus granulosus caspase 8 0.0027 0.0078 0.0073
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0041 0.0182 0.0208
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.053 0.3658 0.4752
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0029 0.0009
Loa Loa (eye worm) cysteine protease 0.0019 0.0022 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0052 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0078 0.0056
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0041 0.0182 0.0208
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.0182 0.0208
Schistosoma mansoni septate junction protein 0.0151 0.096 0.1104
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.004 0.0176 0.02
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0041 0.0182 1
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0033 0.0121 0.0271
Echinococcus multilocularis caspase 0.0027 0.0078 0.0073
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.053 0.3658 0.4642
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0182 0.0227
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0033 0.0121 0.0271
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0071 0.0391 0.3879
Echinococcus multilocularis caspase 8 0.0027 0.0078 0.0073
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0112 0.0687 0.0868
Onchocerca volvulus 0.0978 0.6847 1
Brugia malayi Doublecortin family protein 0.002 0.0029 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Onchocerca volvulus 0.0029 0.0096 0.0108
Echinococcus granulosus carbonic anhydrase 0.053 0.3658 0.4742
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0372 0.035
Schistosoma mansoni carbonic anhydrase-related 0.053 0.3658 0.4246
Loa Loa (eye worm) norepinephrine transporter 0.0243 0.1615 0.2049
Schistosoma mansoni hypothetical protein 0.0151 0.096 0.1104
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.004 0.0176 0.02
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0182 0.0438
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0071 0.0391 0.0523
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0128 0.0801 0.1016
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1097 0.7688 1
Leishmania major hypothetical protein, conserved 0.0085 0.0496 0.0552
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0087 0.011
Onchocerca volvulus Putative cubilin 0.0151 0.096 0.1374
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Schistosoma mansoni hypothetical protein 0.017 0.1098 0.1265
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Trichomonas vaginalis AGC family protein kinase 0.0194 0.1271 0.1252
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.0496 0.0617
Schistosoma mansoni memapsin-2 (A01 family) 0.0096 0.0575 0.0655
Loa Loa (eye worm) cytochrome c oxidase subunit II 0.0018 0.0017 0.0022
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0029 0.0009
Echinococcus granulosus neural cadherin 0.0151 0.096 0.1224
Treponema pallidum sodium- and chloride- dependent transporter 0.0243 0.1615 1
Brugia malayi celfurPC protein 0.0032 0.0118 0.0143
Mycobacterium ulcerans integral membrane transporter 0.0033 0.0121 0.0086
Brugia malayi Animal haem peroxidase family protein 0.0978 0.6847 0.8906
Onchocerca volvulus Protein phosphatase PP2A 55 kDa regulatory subunit homolog 0.0085 0.0496 0.0693
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0027 0.0078 0.0073
Brugia malayi nuclear hormone receptor 0.0028 0.0087 0.0103
Trypanosoma cruzi protein phosphatase 2A regulatory subunit, putative 0.0085 0.0496 0.0617
Echinococcus granulosus protein jagged 1 0.0151 0.096 0.1224
Leishmania major cathepsin L-like protease 0.0072 0.0398 0.0438
Trypanosoma cruzi metacaspase, putative 0.0027 0.0078 0.0073
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.0986 0.1257
Onchocerca volvulus Peroxidase homolog 0.0978 0.6847 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0078 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0078 0.0056
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0087 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0087 0.011
Echinococcus multilocularis voltage dependent calcium channel 0.004 0.0176 0.02
Onchocerca volvulus 0.0041 0.0182 0.0233
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0087 0.0087
Wolbachia endosymbiont of Brugia malayi carbonic anhydrase 0.004 0.0177 0.1544
Brugia malayi EGF-like domain containing protein 0.0151 0.096 0.124
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0976 0.6833 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0087 0.0084
Brugia malayi Cathepsin L-like precursor 0.0019 0.0022 0.0019
Echinococcus multilocularis fibropellin Ia 0.0151 0.096 0.1224
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.004 0.0176 0.0191
Echinococcus granulosus carbonic anhydrase II 0.1097 0.7688 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0561 0.3876 0.4918
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0017 0.0013 0.0007
Echinococcus granulosus neurogenic locus protein delta 0.0151 0.096 0.1224
Brugia malayi Calcium binding EGF domain containing protein 0.0151 0.096 0.124
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Loa Loa (eye worm) hypothetical protein 0.053 0.3658 0.4642
Schistosoma mansoni sodium/chloride dependent transporter 0.0243 0.1615 0.1867
Echinococcus granulosus serotonin transporter 0.0243 0.1615 0.2077
Brugia malayi follicle stimulating hormone receptor 0.0244 0.1627 0.2109
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.004 0.0176 0.02
Echinococcus granulosus geminin 0.017 0.1098 0.1404
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0329 0.0369
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0024 0.0061 0.0039
Brugia malayi serine/threonine protein phosphatase 2A 0.0085 0.0496 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0087 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0087 0.0103
Trypanosoma cruzi protein phosphatase 2A regulatory subunit, putative 0.0085 0.0496 0.0617
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.011
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.004 0.0176 0.0219
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0194 0.1271 0.1613
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.004 0.0176 0.0191
Echinococcus granulosus fibropellin Ia 0.0151 0.096 0.1224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Loa Loa (eye worm) RNA binding protein 0.0062 0.0329 0.0418
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0035 0.0016
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0182 0.0197
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0087 0.0084
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.004 0.0176 0.02
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0787 0.0998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Schistosoma mansoni hypothetical protein 0.0126 0.0787 0.0903
Echinococcus multilocularis serotonin transporter 0.0243 0.1615 0.2077
Onchocerca volvulus 0.002 0.0029 0.001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0035 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0085 0.0496 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0087 0.011
Brugia malayi cytochrome c oxidase subunit II 0.0018 0.0017 0.0012
Trypanosoma brucei metacaspase 0.0027 0.0078 0.0056
Onchocerca volvulus 0.0151 0.096 0.1374
Echinococcus multilocularis neurogenic locus protein delta 0.0151 0.096 0.1224
Echinococcus granulosus microsomal glutathione S transferase 3 0.0112 0.0687 0.0868
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.0182 0.0208
Echinococcus multilocularis carbonic anhydrase 0.053 0.3658 0.4742
Brugia malayi Animal haem peroxidase family protein 0.0978 0.6847 0.8906
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0329 0.0369
Schistosoma mansoni peroxidasin 0.0978 0.6847 0.7962
Echinococcus multilocularis mitogen activated protein kinase 14 0.0128 0.0801 0.1015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0087 0.0103
Schistosoma mansoni hypothetical protein 0.0151 0.096 0.1104
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.004 0.0176 0.02
Loa Loa (eye worm) hypothetical protein 0.004 0.0176 0.0223
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0045 0.021 0.0275
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0087 0.0087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0087 0.0103
Echinococcus multilocularis mitogen activated protein kinase 11 0.0128 0.0801 0.1015
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0071 0.0391 0.3879
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0078 0.0092
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0329 0.0419
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Schistosoma mansoni rab6-interacting 0.002 0.0029 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0078 0.0056
Toxoplasma gondii MAPEG family protein 0.0112 0.0687 0.183
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.1627 0.2065
Brugia malayi Protein kinase domain containing protein 0.0194 0.1271 0.1645
Brugia malayi TAR-binding protein 0.0062 0.0329 0.0419
Echinococcus granulosus caspase 0.0027 0.0078 0.0073
Brugia malayi Angiotensin-converting enzyme family protein 0.0561 0.3876 0.5036
Schistosoma mansoni voltage-gated cation channel 0.004 0.0176 0.0191
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.053 0.3658 0.4752
Echinococcus multilocularis voltage dependent calcium channel 0.004 0.0176 0.02
Trichomonas vaginalis conserved hypothetical protein 0.1422 1 1
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.049 0.3374 0.3916
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0052 0.0017
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0243 0.1615 0.2092
Onchocerca volvulus Putative sulfate transporter 0.0205 0.1347 0.194
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.0182 0.0197
Entamoeba histolytica protein phosphatase regulatory subunit, putative 0.0085 0.0496 0.0552
Brugia malayi nuclear receptor NHR-88 0.0028 0.0087 0.0103
Brugia malayi Cathepsin L-like precursor 0.0019 0.0022 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0087 0.0084
Echinococcus multilocularis neural cadherin 0.0151 0.096 0.1224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Leishmania major hypothetical protein, conserved 0.004 0.0177 0.018
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0087 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0194 0.1271 0.1252
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0289 0.0348
Onchocerca volvulus Cell death protein 3 homolog 0.0089 0.0519 0.0727
Trypanosoma brucei protein phosphatase 2A regulatory subunit, putative 0.0085 0.0496 0.0602
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0121 0.0112
Brugia malayi hypothetical protein 0.0978 0.6847 0.8906
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0779 0.5431 0.7937
Brugia malayi hypothetical protein 0.0062 0.0329 0.0419
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0041 0.0182 0.0208
Toxoplasma gondii hypothetical protein 0.053 0.3658 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0128 0.0801 0.1015
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0087 0.0084
Echinococcus granulosus neurogenic locus notch protein 4 0.0151 0.096 0.1224
Echinococcus granulosus dynactin 5 p25 0.0071 0.0391 0.048
Echinococcus granulosus mitogen activated protein kinase 14 0.0128 0.0801 0.1015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0096 0.0098
Loa Loa (eye worm) blistered cuticle protein 3 0.0978 0.6847 0.869
Onchocerca volvulus 0.0151 0.096 0.1374
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0121 0.0129
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.0182 0.0197
Trypanosoma cruzi metacaspase, putative 0.0027 0.0078 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0087 0.0087
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.011
Loa Loa (eye worm) hypothetical protein 0.0243 0.1615 0.2049
Echinococcus granulosus protein jagged 1 0.0151 0.096 0.1224
Echinococcus multilocularis protein jagged 2 0.0151 0.096 0.1224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Loa Loa (eye worm) carbonic anhydrase 3 0.1097 0.7688 0.9756
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0087 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0087 0.0103
Echinococcus multilocularis protein jagged 1 0.0151 0.096 0.1224
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1224 0.8597 1
Loa Loa (eye worm) serine/threonine protein phosphatase 2A 0.0085 0.0496 0.0629
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0182 0.0197
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0128 0.0801 0.1
Plasmodium falciparum metacaspase-like protein 0.0027 0.0078 0.0153
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0022 0.0028
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Echinococcus granulosus protein jagged 2 0.0151 0.096 0.1224
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.047 0.3232 0.3751
Schistosoma mansoni protein phosphatase pp2a regulatory subunit B 0.0085 0.0496 0.0563
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0182 0.0227
Schistosoma mansoni hypothetical protein 0.017 0.1098 0.1265
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0045 0.021 0.0275
Echinococcus multilocularis geminin 0.017 0.1098 0.1404
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.004 0.0176 0.02
Onchocerca volvulus 0.0041 0.0182 0.0233
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0128 0.0801 0.0908
Loa Loa (eye worm) animal heme peroxidase 0.0978 0.6847 0.869
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0231
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0078 0.0056
Schistosoma mansoni hypothetical protein 0.0151 0.096 0.1104
Echinococcus granulosus cytochrome c oxidase subunit II 0.0149 0.0952 0.1212
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.0182 0.0231
Echinococcus multilocularis carbonic anhydrase 0.053 0.3658 0.4742
Brugia malayi EGF-like domain containing protein 0.0151 0.096 0.124
Echinococcus granulosus notch 0.0151 0.096 0.1224
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0231
Loa Loa (eye worm) hypothetical protein 0.0978 0.6847 0.869
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0035 0.0013
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0052 0.0022
Brugia malayi notch-like transmembrane receptor 0.0151 0.096 0.124
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0398 0.049
Onchocerca volvulus 0.0205 0.1347 0.194
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0182 0.0197
Loa Loa (eye worm) solute carrier family 6 member 4 0.0243 0.1615 0.2049
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.004 0.0173 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0398 0.0475
Mycobacterium ulcerans transferase 0.0068 0.0372 0.0338
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1097 0.7688 0.8941
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0078 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0087 0.011
Echinococcus granulosus RUN 0.002 0.0029 0.0009
Brugia malayi EGF-like domain containing protein 0.0151 0.096 0.124
Schistosoma mansoni sodium-dependent amino acid transporter 0.0041 0.0182 0.0197
Echinococcus granulosus furin 0.004 0.0173 0.0196
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0177 0.0185
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.0182 0.0208
Schistosoma mansoni rab6-interacting 0.002 0.0029 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0259 0.0329
Echinococcus multilocularis slit 2 protein 0.0151 0.096 0.1224
Brugia malayi Cytochrome P450 family protein 0.0023 0.0052 0.0057
Toxoplasma gondii hypothetical protein 0.0041 0.0182 0.0438
Brugia malayi Muscle positioning protein 4 0.0151 0.096 0.124
Leishmania major cathepsin L-like protease 0.0072 0.0398 0.0438
Schistosoma mansoni hypothetical protein 0.0151 0.096 0.1104
Onchocerca volvulus 0.002 0.0029 0.001
Brugia malayi Delta serrate ligand family protein 0.0151 0.096 0.124
Loa Loa (eye worm) Notch2 0.0151 0.096 0.1219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0087 0.011
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0194 0.1271 0.1629
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0035 0.0016
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0182 0.0438
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.1271 0.1467
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1336 0.1696
Loa Loa (eye worm) hypothetical protein 0.0151 0.096 0.1219
Toxoplasma gondii transporter, cation channel family protein 0.004 0.0176 0.0422
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1537 0.1518
Echinococcus multilocularis 0.0032 0.0118 0.0124

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.06 ug ml-1 In vitro minimum inhibitory concentration for Escherichia coli (ATCC-10536) by agar dilution method ChEMBL. 7966140

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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