Detailed information for compound 1192083

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1894.24 | Formula: C85H144N20O26S
  • H donors: 24 H acceptors: 27 LogP: -1.83 Rotable bonds: 84
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CC(=O)N)CCC(=O)O)[C@@H](O)C)Cc1[nH]cnc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCCCCCCCCCCCCCC)C)CCC(=O)O)CCC(=O)O)CO)CS)CC(C)C)C
  • InChi: 1S/C85H144N20O26S/c1-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-30-64(110)91-48(6)72(118)93-55(33-36-67(115)116)76(122)103-70(51(9)108)84(130)102-68(47(4)5)82(128)94-54(32-35-66(113)114)75(121)100-60(43-106)79(125)101-61(44-132)80(126)98-58(39-46(2)3)77(123)92-49(7)73(119)96-56(28-25-26-37-86)85(131)105-38-27-29-62(105)81(127)99-59(40-52-42-89-45-90-52)78(124)104-69(50(8)107)83(129)95-53(31-34-65(111)112)74(120)97-57(71(88)117)41-63(87)109/h42,45-51,53-62,68-70,106-108,132H,10-41,43-44,86H2,1-9H3,(H2,87,109)(H2,88,117)(H,89,90)(H,91,110)(H,92,123)(H,93,118)(H,94,128)(H,95,129)(H,96,119)(H,97,120)(H,98,126)(H,99,127)(H,100,121)(H,101,125)(H,102,130)(H,103,122)(H,104,124)(H,111,112)(H,113,114)(H,115,116)/t48-,49-,50-,51+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,68-,69-,70-/m0/s1
  • InChiKey: GSBGOYBOHYJVHV-QWWMRAHESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0003 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Echinococcus multilocularis protein patched 0.0127 0.0109 0.0107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.029
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0019 0.0434
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0071 0.0321
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0071 0.0251
Mycobacterium ulcerans acyl-CoA synthetase 0.0296 0.0275 0.0999
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0425 0.0401 0.04
Schistosoma mansoni cellular tumor antigen P53 0.0511 0.0485 0.0483
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0008 0.0129
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0095 0.0093
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0016
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0002 0.0009
Loa Loa (eye worm) beta-lactamase 0.0112 0.0095 0.0433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0106 0.0374
Onchocerca volvulus 0.0034 0.0019 0.0331
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0018 0.0082
Echinococcus multilocularis peptidase Clp (S14 family) 0.0273 0.0253 0.0251
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0113 1
Schistosoma mansoni ferritin light chain 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0105 0.0088 0.0403
Onchocerca volvulus 0.0028 0.0013 0.0199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0095 0.0433
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0034 0.293
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0014 1
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0019 0.0331
Echinococcus multilocularis ferritin 0.0018 0.0003 0.0002
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0417 0.0393 0.0391
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.002 0.0685
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0087 0.0071 0.1754
Brugia malayi hypothetical protein 0.0425 0.0401 0.1827
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Onchocerca volvulus 0.0034 0.0019 0.0331
Schistosoma mansoni apoferritin-2 0.0018 0.0003 0.0002
Plasmodium vivax patched family protein, putative 0.0018 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0296 0.0275 0.1253
Plasmodium falciparum glutathione reductase 0.0049 0.0033 0.0793
Echinococcus multilocularis muscleblind protein 0.0145 0.0128 0.0126
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.002 0.0431
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0019 0.0331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0073
Schistosoma mansoni hypothetical protein 0.0425 0.0401 0.04
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0055
Echinococcus multilocularis tumor protein p63 0.3491 0.3399 0.3398
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0094 0.0336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Echinococcus multilocularis lamin 0.0028 0.0013 0.0011
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2815 0.2738 1
Echinococcus granulosus cathepsin L 0.0018 0.0003 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0047 0.0045
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0034 0.0816
Loa Loa (eye worm) patched family protein 0.0018 0.0003 0.0014
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.002 0.0378
Brugia malayi hypothetical protein 0.0018 0.0003 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0095 0.0341
Brugia malayi Pre-SET motif family protein 0.0441 0.0417 0.1899
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Leishmania major 4-coumarate:coa ligase-like protein 0.0296 0.0275 1
Onchocerca volvulus 0.0461 0.0436 0.8991
Onchocerca volvulus 0.0087 0.0071 0.1401
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0141 0.064
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0071 0.0251
Plasmodium vivax acyl-CoA synthetase, putative 0.0221 0.0202 0.5115
Echinococcus multilocularis cysteine protease 0.0034 0.0019 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.002 0.1681
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0296 0.0275 0.0999
Brugia malayi cathepsin L-like precursor 0.0023 0.0008 0.0036
Echinococcus granulosus cathepsin l1 0.0023 0.0008 0.0006
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0003 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Echinococcus multilocularis survival motor neuron protein 1 0.2261 0.2196 0.2195
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0002
Echinococcus multilocularis expressed protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0295 0.0274 0.1247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3231 0.3144 0.3143
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0071 0.0251
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0014 0.1059
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.0051
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.003
Leishmania major cathepsin L-like protease 0.0034 0.0019 0.0649
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0087 0.0071 0.0251
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.002 0.0091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0019 0.0358
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.002 0.0378
Leishmania major cathepsin L-like protease 0.0034 0.0019 0.0649
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Loa Loa (eye worm) hypothetical protein 0.0112 0.0095 0.0433
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0106 0.0104
Echinococcus granulosus tar DNA binding protein 0.0062 0.0046 0.0044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0004 0.0002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0296 0.0275 0.6834
Brugia malayi AMP-binding enzyme family protein 0.0296 0.0275 0.1253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0019 0.0086
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0004 0.0062
Schistosoma mansoni hypothetical protein 0.0122 0.0105 0.0103
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Echinococcus multilocularis protein dispatched 1 0.0144 0.0127 0.0125
Loa Loa (eye worm) hypothetical protein 0.0087 0.0071 0.0321
Onchocerca volvulus 0.0063 0.0047 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0109 0.226
Echinococcus granulosus expressed conserved protein 0.0277 0.0256 0.0254
Loa Loa (eye worm) hypothetical protein 0.0112 0.0095 0.0433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0295 0.0274 0.68
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0417 0.0393 0.1429
Toxoplasma gondii hypothetical protein 0.0144 0.0126 0.317
Mycobacterium tuberculosis Conserved protein 0.0112 0.0095 0.0341
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.002 0.0378
Brugia malayi RNA binding protein 0.0062 0.0046 0.0208
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0296 0.0275 0.0999
Brugia malayi Pre-SET motif family protein 0.0063 0.0047 0.0216
Brugia malayi Niemann-Pick C1 protein precursor 0.0295 0.0274 0.1247
Schistosoma mansoni hypothetical protein 0.0461 0.0436 0.0435
Trypanosoma brucei trypanothione reductase 0.0049 0.0033 0.2796
Brugia malayi hypothetical protein 0.2261 0.2196 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0087 0.0071 0.0251
Brugia malayi hypothetical protein 0.0049 0.0034 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0296 0.0275 0.0999
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0095 0.8416
Echinococcus multilocularis Niemann Pick C1 protein 0.0295 0.0274 0.0272
Loa Loa (eye worm) patched family protein 0.0018 0.0003 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0209 0.019 0.0688
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0071 0.0251
Plasmodium vivax vivapain-1 0.0018 0.0003 0.002
Toxoplasma gondii patched family protein 0.0018 0.0003 0.0027
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0046 0.0208
Loa Loa (eye worm) hypothetical protein 0.0145 0.0128 0.0581
Schistosoma mansoni thyroid hormone receptor 0.0133 0.0116 0.0114
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0003 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0047 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0071 0.0251
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0087 0.0071 0.0251
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Toxoplasma gondii hypothetical protein 0.0018 0.0003 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0095 0.0341
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0106 0.038
Loa Loa (eye worm) hypothetical protein 0.0072 0.0056 0.0254
Mycobacterium ulcerans lipase LipD 0.0112 0.0095 0.0341
Loa Loa (eye worm) hypothetical protein 0.0296 0.0275 0.1253
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0087 0.0071 0.0321
Onchocerca volvulus 0.0112 0.0095 0.1912
Plasmodium vivax SET domain protein, putative 0.0063 0.0047 0.1163
Schistosoma mansoni patched 1 0.0127 0.0109 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0296 0.0275 0.0999
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0417 0.0393 1
Echinococcus granulosus muscleblind protein 0.0145 0.0128 0.0126
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0004 0.002
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0095 0.0341
Trypanosoma brucei glucosidase, putative 0.0035 0.002 0.162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.0122 0.0105 0.0103
Loa Loa (eye worm) oxidoreductase 0.0087 0.0071 0.0321
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0034 0.0816
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0141 0.0139
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0417 0.0393 1
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0113 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0095 0.8416
Onchocerca volvulus 0.0087 0.0071 0.1401
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0417 0.0393 0.1424
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0087 0.0071 0.1701
Onchocerca volvulus 0.0087 0.0071 0.1401
Leishmania major hypothetical protein, conserved 0.0112 0.0095 0.3431
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0013 0.0057
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0144 0.0126 0.0448
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0112 0.0095 0.0433
Leishmania major 4-coumarate:coa ligase-like protein 0.0296 0.0275 1
Brugia malayi protein C24B5.3 0.0018 0.0003 0.0014
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0221 0.0202 0.0731
Loa Loa (eye worm) patched family protein 0.0018 0.0003 0.0014
Onchocerca volvulus 0.0511 0.0485 1
Mycobacterium ulcerans transcriptional regulator 0.2815 0.2738 1
Echinococcus multilocularis expressed conserved protein 0.0277 0.0256 0.0254
Echinococcus granulosus GPCR family 2 0.0033 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0063 0.0047 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0019 0.0358
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.0086 0.756
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Schistosoma mansoni lamin 0.0028 0.0013 0.0011
Schistosoma mansoni survival motor neuron protein 0.0461 0.0436 0.0435
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0128 0.0126
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0087 0.0071 0.0321
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0071 0.0251
Echinococcus multilocularis cathepsin L 0.0018 0.0003 0.0001
Echinococcus granulosus cysteine protease 0.0018 0.0003 0.0001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.002 0.0378
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0417 0.0393 1
Echinococcus multilocularis lamin dm0 0.0028 0.0013 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0296 0.0275 0.0999
Brugia malayi beta-lactamase family protein 0.0112 0.0095 0.0433
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0002 0.003
Brugia malayi Cathepsin L-like precursor 0.0034 0.0019 0.0086
Brugia malayi Cathepsin L-like precursor 0.0034 0.0019 0.0086
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0003 0.0027
Echinococcus multilocularis microtubule associated protein 2 1.0242 1 1
Onchocerca volvulus 0.0023 0.0008 0.0101
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0425 0.0401 0.04
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0003 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0071 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0003 0.007
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2815 0.2738 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0094 0.0336
Echinococcus granulosus lamin dm0 0.0028 0.0013 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0095 0.0341
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0087 0.0071 0.0245
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0071 0.0321
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0003 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0095 0.1963
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.002 0.0378
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0002 0.0073
Leishmania major trypanothione reductase 0.0049 0.0033 0.1161
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0087 0.0071 0.0251
Onchocerca volvulus 0.0087 0.0071 0.1401
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0019 0.0017
Echinococcus granulosus cathepsin l1 0.0034 0.0019 0.0017
Brugia malayi protein C24B5.3 0.0018 0.0003 0.0014
Echinococcus multilocularis cysteine protease 0.0034 0.0019 0.0017
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0095 0.0341
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0004 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0094 0.0336
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0004 0.207
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0087 0.0071 0.0251
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0004 0.0062
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0003 0.004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0004 0.0042
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0003 0.007
Schistosoma mansoni ferritin light chain 0.0018 0.0003 0.0002
Schistosoma mansoni apoferritin-2 0.0018 0.0003 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0004 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0296 0.0275 0.0993
Brugia malayi Cathepsin L-like precursor 0.0034 0.0019 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Brugia malayi hypothetical protein 0.0018 0.0003 0.0014
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.002 0.0018
Toxoplasma gondii patched family protein 0.0018 0.0003 0.0027
Mycobacterium tuberculosis Probable reductase 0.0111 0.0094 0.0336
Schistosoma mansoni intermediate filament proteins 0.0028 0.0013 0.0011
Schistosoma mansoni lamin 0.0028 0.0013 0.0011
Entamoeba histolytica hypothetical protein 0.0425 0.0401 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0019 0.0086
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0045 0.0043
Brugia malayi Probable ClpP-like protease 0.0417 0.0393 0.1789
Brugia malayi hypothetical protein 0.0018 0.0003 0.0014
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0273 0.0253 0.0916
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0273 0.0253 0.0916
Loa Loa (eye worm) hypothetical protein 0.0155 0.0137 0.0624
Schistosoma mansoni alpha-glucosidase 0.0136 0.0119 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0019 0.1593
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.0051
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0087 0.0071 0.6186
Brugia malayi beta-lactamase family protein 0.0112 0.0095 0.0433
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0094 0.0336
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.002 0.0378
Echinococcus granulosus survival motor neuron protein 1 0.2261 0.2196 0.2195
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0087 0.0071 0.0251
Onchocerca volvulus 0.0034 0.0019 0.0331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0296 0.0275 0.1253
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0013 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.002 0.0459
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0417 0.0393 0.0391
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Schistosoma mansoni microtubule-associated protein tau 1.0242 1 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0087 0.0071 0.0251
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0087 0.0071 0.0251
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0046 0.0044
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0087 0.0071 0.0251
Schistosoma mansoni ferritin 0.0018 0.0003 0.0002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0033 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.002 0.1681
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0144 0.0126 0.317
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0003 0.0142
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0209 0.019 0.0688
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0004 0.0002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0716 0.0686 0.25
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0417 0.0393 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0071 0.0251
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0141 0.064
Loa Loa (eye worm) hypothetical protein 0.0511 0.0485 0.2209
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0071 0.0251
Echinococcus multilocularis musashi 0.0028 0.0013 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0003 0.0012
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0019 0.0017
Entamoeba histolytica acyl-coA synthetase, putative 0.0296 0.0275 0.6834
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.0417 0.1899
Leishmania major acetyl-CoA synthetase, putative 0.0087 0.0071 0.2533
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0087 0.0071 0.0245
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0106 0.0104
Schistosoma mansoni flap endonuclease-1 0.0026 0.0011 0.0009
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0087 0.0071 0.0321
Onchocerca volvulus 0.0296 0.0275 0.5645
Brugia malayi Myosin head containing protein 0.0018 0.0003 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Loa Loa (eye worm) hypothetical protein 0.0127 0.0109 0.0497
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0087 0.0071 0.0251
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0095 0.1963
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0073
Schistosoma mansoni alpha glucosidase 0.0035 0.002 0.0018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0296 0.0275 0.0999
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0087 0.0071 0.0245
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0018 0.0082
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0019 0.0649
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0127 0.0109 0.0497
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0071 0.0251
Brugia malayi AMP-binding enzyme family protein 0.0296 0.0275 0.1253
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0044
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0417 0.0393 0.1429
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0018 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0004 0.0118
Echinococcus multilocularis sterol regulatory element binding protein 0.0127 0.0109 0.0107
Schistosoma mansoni ferritin 0.0018 0.0003 0.0002
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0087 0.0071 0.1754
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0016
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0003 0.002
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0019 0.0406
Schistosoma mansoni hypothetical protein 0.0022 0.0007 0.0005
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0003 0.0006
Toxoplasma gondii cathepsin CPL 0.0034 0.0019 0.0434
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0088 0.0403
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0056 0.0254
Plasmodium vivax glutathione reductase, putative 0.0049 0.0033 0.0793
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Mycobacterium ulcerans TetR family transcriptional regulator 0.2815 0.2738 1
Schistosoma mansoni ferritin 0.0018 0.0003 0.0002
Brugia malayi Thioredoxin reductase 0.0049 0.0033 0.015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0033 0.015
Brugia malayi Cathepsin L-like precursor 0.0034 0.0019 0.0086
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0003 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0047 0.0045
Toxoplasma gondii patched family protein 0.0018 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0417 0.0393 0.1789
Toxoplasma gondii thioredoxin reductase 0.0049 0.0033 0.0793
Plasmodium vivax unspecified product 0.0018 0.0003 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0047 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Echinococcus granulosus sterol regulatory element binding protein 0.0127 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0112 0.0095 0.0433
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0087 0.0071 0.0251
Plasmodium falciparum thioredoxin reductase 0.0049 0.0033 0.0793
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0018 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0095 0.1963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Schistosoma mansoni ferritin 0.0018 0.0003 0.0002
Toxoplasma gondii exonuclease III APE 0.0019 0.0004 0.0062
Brugia malayi Patched related family protein 10 0.0018 0.0003 0.0014
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0141 0.0139
Onchocerca volvulus 0.0112 0.0095 0.1912
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Onchocerca volvulus 0.0502 0.0477 0.9827
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Trichomonas vaginalis antibiotic synthetase, putative 0.0087 0.0071 0.1445
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0047 0.1163
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0087 0.0071 0.6214
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0034 0.2878
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0095 0.1963
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Loa Loa (eye worm) patched family protein 0.0018 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0049 0.0034 0.0154
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0144 0.0126 0.317
Toxoplasma gondii propionate-CoA ligase 0.0087 0.0071 0.1754
Plasmodium vivax vivapain-2 0.0034 0.0019 0.0434
Brugia malayi Patched protein homolog 1 0.0018 0.0003 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0095 0.0341
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0033 0.2849
Mycobacterium tuberculosis Conserved protein 0.0112 0.0095 0.0341
Brugia malayi Flap endonuclease-1 0.0029 0.0014 0.0062
Schistosoma mansoni hypothetical protein 0.0122 0.0105 0.0103
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0106 0.038
Entamoeba histolytica hypothetical protein 0.0425 0.0401 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Schistosoma mansoni transcription factor LCR-F1 0.0425 0.0401 0.04
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0071 0.0251
Echinococcus granulosus Protein patched homolog 1 0.0127 0.0109 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0019 0.0358
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.0102 0.9011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0133 0.0116 0.0114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0019 0.0406
Loa Loa (eye worm) glutathione reductase 0.0049 0.0033 0.015
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0019 0.0434
Brugia malayi beta-lactamase 0.0112 0.0095 0.0433
Loa Loa (eye worm) hypothetical protein 0.0221 0.0202 0.0919
Loa Loa (eye worm) hypothetical protein 0.0221 0.0202 0.0919
Onchocerca volvulus 0.0034 0.0019 0.0331
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0003 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0044
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0019 0.0086
Loa Loa (eye worm) cysteine protease 0.0034 0.0019 0.0086
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.002 0.0018
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0086
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0018 0.0016
Brugia malayi TAR-binding protein 0.0062 0.0046 0.0208
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0417 0.0393 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0071 0.0321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Echinococcus granulosus Niemann Pick C1 protein 0.0295 0.0274 0.0272
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0047 0.0045
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0014 0.0062
Plasmodium vivax acetyl-CoA synthetase, putative 0.0087 0.0071 0.1754
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0087 0.0071 0.6214
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0087 0.0071 0.0251
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0019 0.0017
Leishmania major cathepsin L-like protease 0.0034 0.0019 0.0649
Echinococcus multilocularis Niemann Pick C1 protein 0.0421 0.0398 0.0396
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0221 0.0202 0.0919
Loa Loa (eye worm) hypothetical protein 0.0145 0.0128 0.0581
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0088 0.0403
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.0116 0.0114
Loa Loa (eye worm) patched family protein 0.0018 0.0003 0.0014
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0087 0.0071 0.0251
Echinococcus granulosus flap endonuclease 1 0.0029 0.0014 0.0012
Entamoeba histolytica hypothetical protein 0.0425 0.0401 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0417 0.0393 1
Leishmania major cathepsin L-like protease 0.0034 0.0019 0.0649
Schistosoma mansoni alpha-glucosidase 0.0136 0.0119 0.0117
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0296 0.0275 0.0999
Trichomonas vaginalis antibiotic synthetase, putative 0.0087 0.0071 0.1445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0033 0.0793
Onchocerca volvulus 0.0034 0.0019 0.0331
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0014 0.0458
Loa Loa (eye worm) fibroinase 0.0034 0.0019 0.0086
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0046 0.0208
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0019 0.0331
Leishmania major acetyl-CoA synthetase, putative 0.0087 0.0071 0.2533
Schistosoma mansoni hypothetical protein 0.0123 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.0112 0.0095 0.0433
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0095 0.0341
Echinococcus multilocularis GPCR, family 2 0.0033 0.0018 0.0016
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0087 0.0071 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0059 0.0208
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.002 0.0378
Brugia malayi hypothetical protein 0.0018 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0461 0.0436 0.1987
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0095 0.0093
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0014 0.03
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.002 0.0431
Mycobacterium ulcerans beta-lactamase 0.0112 0.0095 0.0341
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0019 0.0017
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0087 0.0071 0.2533
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Leishmania major hypothetical protein, conserved 0.0049 0.0034 0.1194
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0095 0.0093
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0087 0.0071 0.6186
Plasmodium falciparum acyl-CoA synthetase 0.0221 0.0202 0.5115
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0087 0.0071 0.0069
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0113 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0296 0.0275 0.0999
Plasmodium falciparum flap endonuclease 1 0.0029 0.0014 0.03
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0019 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0014 0.0012
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0087 0.0071 0.6214
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0013 0.0057
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0014 0.03
Echinococcus granulosus expressed protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0112 0.0095 0.0433
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0004 0.002
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0019 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0008 0.0125
Trichomonas vaginalis set domain proteins, putative 0.0502 0.0477 1
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0016
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.002 0.0091
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.002 0.0378
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0046 0.0208
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0095 0.0433
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0095 0.2384
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0019 0.0017
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0002 0.0073
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0019 0.0017
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.003
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0019 0.0086
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0095 0.0341
Brugia malayi Cathepsin L-like precursor 0.0023 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0221 0.0202 0.0919
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0095 0.0335
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0003 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0095 0.1963
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0087 0.0071 0.6214
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0002 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0057
Schistosoma mansoni acetyl-CoA synthetase 0.0087 0.0071 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0209 0.019 0.0688
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0036
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0087 0.0071 0.1754
Leishmania major cathepsin L-like protease 0.013 0.0113 0.4077
Onchocerca volvulus 0.0112 0.0095 0.1912
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Brugia malayi Patched family protein 0.0018 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Plasmodium vivax vivapain-2 0.0034 0.0019 0.0434
Mycobacterium ulcerans hypothetical protein 0.0112 0.0095 0.0341
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0144 0.0126 0.317
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0019 0.0017
Trichomonas vaginalis ferritin, putative 0.0018 0.0003 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0113 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0417 0.0393 0.0391
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0106 0.038
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0094 0.033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0072 0.0056 0.0054
Leishmania major cathepsin L-like protease 0.013 0.0113 0.4077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0087 0.0071 0.0251
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0417 0.0393 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0033 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0016
Echinococcus granulosus peptidase Clp S14 family 0.0273 0.0253 0.0251
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0002 0.003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0141 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0071 0.0251
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Toxoplasma gondii ABC1 family protein 0.0112 0.0095 0.2384
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0044
Onchocerca volvulus 0.0028 0.0013 0.0199
Brugia malayi glutathione reductase 0.0049 0.0033 0.015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0007 0.0005
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0087 0.0071 0.0321
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0003 0.0142
Entamoeba histolytica hypothetical protein 0.0425 0.0401 1
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0095 0.0341
Echinococcus granulosus tumor protein p63 0.3491 0.3399 0.3398
Loa Loa (eye worm) hypothetical protein 0.0296 0.0275 0.1253
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0071 0.0321
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0417 0.0393 1
Echinococcus granulosus Niemann Pick C1 protein 0.0421 0.0398 0.0396
Mycobacterium ulcerans acetyl-CoA synthetase 0.0087 0.0071 0.0251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0088 0.0403
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0047 0.0045
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0034 0.0816
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0094 0.0336
Loa Loa (eye worm) RNA binding protein 0.0062 0.0046 0.0208
Leishmania major cathepsin L-like protease 0.0034 0.0019 0.0649
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0273 0.0253 0.0911
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0221 0.0202 0.5115
Entamoeba histolytica cysteine protease, putative 0.0034 0.0019 0.0406
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0003 0.0001
Toxoplasma gondii patched family protein 0.0018 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0036
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0014 0.0275
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0014 0.1124
Brugia malayi Patched related family protein 4 0.0018 0.0003 0.0014
Brugia malayi hypothetical protein 0.0032 0.0017 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0034 0.293
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0016
Loa Loa (eye worm) ctsf protein 0.0034 0.0019 0.0086
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0018 0.0016
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0014 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Trichomonas vaginalis esterase, putative 0.0112 0.0095 0.1963
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0221 0.0202 0.0731
Entamoeba histolytica acyl-CoA synthetase, putative 0.0296 0.0275 0.6834
Loa Loa (eye worm) hypothetical protein 0.2261 0.2196 1
Onchocerca volvulus 0.0034 0.0019 0.0331
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0034 0.0816
Brugia malayi CHE-14 protein 0.0127 0.0109 0.0497
Echinococcus granulosus lamin 0.0028 0.0013 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0008 0.0125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0062
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0087 0.0071 0.0251
Mycobacterium leprae Probable lipase LipE 0.0112 0.0095 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0033 0.0031
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2815 0.2738 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0044
Brugia malayi Patched related family protein 12 0.0018 0.0003 0.0014
Onchocerca volvulus 0.0092 0.0075 0.1497
Loa Loa (eye worm) hypothetical protein 0.0221 0.0202 0.0919
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0003 0.004
Onchocerca volvulus 0.0034 0.0019 0.0331
Mycobacterium tuberculosis Conserved protein 0.0112 0.0095 0.0341
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0095 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0087 0.0071 0.0251
Brugia malayi Cathepsin L-like precursor 0.0023 0.0008 0.0036
Mycobacterium ulcerans hypothetical protein 0.0296 0.0275 0.0999
Schistosoma mansoni hypothetical protein 0.0122 0.0105 0.0103
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0296 0.0275 0.0993
Brugia malayi intermediate filament protein 0.0028 0.0013 0.0057
Echinococcus granulosus ferritin 0.0018 0.0003 0.0002
Leishmania major cathepsin L-like protease 0.013 0.0113 0.4077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0019 0.0358
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0004 0.029
Echinococcus granulosus intermediate filament protein 0.0028 0.0013 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0047 0.0045
Plasmodium vivax vivapain-3 0.0018 0.0003 0.002
Trypanosoma cruzi cruzipain precursor, putative 0.013 0.0113 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0209 0.019 0.0688
Brugia malayi Muscleblind-like protein 0.0145 0.0128 0.0581
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0003 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.002 0.0378
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0095 0.8405
Leishmania major 4-coumarate:coa ligase-like protein 0.0296 0.0275 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0299 0.0278 0.0276

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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