Detailed information for compound 1230797

Basic information

Technical information
  • TDR Targets ID: 1230797
  • Name: N-[(2-chloro-6-fluorophenyl)methyl]-1,1-di(ph enyl)methanamine hydrochloride
  • MW: 362.268 | Formula: C20H18Cl2FN
  • H donors: 1 H acceptors: 0 LogP: 6.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1CNC(c1ccccc1)c1ccccc1)Cl.Cl
  • InChi: 1S/C20H17ClFN.ClH/c21-18-12-7-13-19(22)17(18)14-23-20(15-8-3-1-4-9-15)16-10-5-2-6-11-16;/h1-13,20,23H,14H2;1H
  • InChiKey: GDDXOVDCNNYUFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2-chloro-6-fluoro-phenyl)methyl]-1,1-di(phenyl)methanamine hydrochloride
  • (2-chloro-6-fluoro-benzyl)-[di(phenyl)methyl]amine hydrochloride
  • MLS000544834
  • N-benzhydryl-N-(2-chloro-6-fluorobenzyl)amine
  • SMR000160706

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.0187 0.2375
Schistosoma mansoni gabp alpha 0.0072 0.0031 0.0358
Leishmania major hypothetical protein, conserved 0.4264 0.3627 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0021 0.0231
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.034 0.0261 0.0743
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0038 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.073 0.9622
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.0187 0.2468
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0899 0.074 0.2034
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0241 0.0176 0.0173
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0176 0.05
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0005 0.0002
Leishmania major phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.0343
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0008 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0005 0.0032
Loa Loa (eye worm) inositol-1 0.0045 0.0008 0.0101
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0313 0.0238 0.3062
Leishmania major phosphatidylinositol 3-kinase, putative 0.0887 0.073 0.2005
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.012 0.1556
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0009 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0943 0.0778 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0005 0.0086
Entamoeba histolytica hypothetical protein 0.0524 0.0419 0.5473
Mycobacterium tuberculosis Conserved protein 0.0041 0.0005 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0021 0.0231
Entamoeba histolytica hypothetical protein 0.0184 0.0127 0.1594
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0005 0.0086
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.0127 0.1679
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.0358
Mycobacterium ulcerans hypothetical protein 0.0041 0.0005 0.0994
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0519 0.0415 0.5424
Echinococcus multilocularis 0.0184 0.0127 0.0124
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.002 0.0048
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0005 0.002
Brugia malayi beta-lactamase family protein 0.0041 0.0005 0.0021
Echinococcus granulosus serine protein kinase ATM 0.0524 0.0419 0.0416
Loa Loa (eye worm) hypothetical protein 0.006 0.0021 0.0277
Trypanosoma brucei cytochrome P450, putative 0.0059 0.002 0.0221
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0176 0.2293
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0943 0.0778 0.2236
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0184 0.0127 0.1653
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0622 0.0503 0.6621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.0136 0.1769
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0176 0.0173
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0887 0.073 0.9622
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0008 0.007
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0943 0.0778 0.0775
Loa Loa (eye worm) CYP4Cod1 0.0059 0.002 0.0262
Loa Loa (eye worm) hypothetical protein 0.0379 0.0295 0.3886
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0241 0.0176 0.0173
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0438 0.0345 0.4493
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0005 0.0005
Brugia malayi Cytochrome P450 family protein 0.0124 0.0076 0.0939
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0176 0.0478
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0008 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0005 0.0021
Trichomonas vaginalis esterase, putative 0.0041 0.0005 0.0032
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0184 0.0127 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0005 0.0032
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0943 0.0778 0.0775
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0038 0.0458
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0005 0.0061
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0038 0.0447
Entamoeba histolytica hypothetical protein 0.0551 0.0442 0.5782
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.02 0.0141 0.0399
Entamoeba histolytica hypothetical protein 0.0184 0.0127 0.1594
Loa Loa (eye worm) phosphatidylinositol 3 0.092 0.0759 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0184 0.0127 0.1603
Mycobacterium ulcerans beta-lactamase 0.0041 0.0005 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.092 0.0759 1
Onchocerca volvulus 0.0535 0.0428 1
Trichomonas vaginalis conserved hypothetical protein 0.0323 0.0247 0.3231
Loa Loa (eye worm) phosphatidylinositol 3 0.0899 0.074 0.9759
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0313 0.0238 0.0676
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.092 0.0759 0.2179
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0241 0.0176 0.2236
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0008 0.007
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0005 0.0086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0005 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.09 0.0741 0.9768
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0241 0.0176 0.2327
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.092 0.0759 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0005 0.0021
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0184 0.0127 0.1594
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0176 0.0173
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0524 0.0419 0.5362
Brugia malayi beta-lactamase 0.0041 0.0005 0.0021
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0622 0.0503 0.6621
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0093 0.1227
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0622 0.0503 0.1442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.073 0.9622
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0184 0.0127 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0899 0.074 0.9758
Schistosoma mansoni hypothetical protein 0.0873 0.0718 0.9231
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0038 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0005 0.0032
Toxoplasma gondii ABC1 family protein 0.0041 0.0005 0.0022
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0422 0.0331 0.0328
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.0127 0.1679
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0241 0.0176 0.2247
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0184 0.0127 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Brugia malayi Ets-domain containing protein 0.0072 0.0031 0.0358
Schistosoma mansoni inositol monophosphatase 0.0045 0.0008 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0528 0.0422 0.5552
Brugia malayi Cytochrome P450 family protein 0.0059 0.002 0.0216
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.024 0.0176 0.2315
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0005 0.0086
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0574 0.0461 0.6068
Schistosoma mansoni ets-related 0.0218 0.0156 0.1973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9739
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0184 0.0127 0.1645
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0622 0.0503 0.6597
Echinococcus granulosus neuropeptide s receptor 0.0973 0.0804 0.0801
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0184 0.0127 0.1603
Leishmania major phosphatidylinositol kinase, putative 0.0184 0.0127 0.0343
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0008 0.007
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.092 0.0759 0.0756
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.092 0.0759 0.2084
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0524 0.0419 0.5362
Trichomonas vaginalis conserved hypothetical protein 0.0563 0.0453 0.5956
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0038 0.01
Plasmodium vivax hypothetical protein, conserved 0.0184 0.0127 0.7143
Onchocerca volvulus 0.0184 0.0127 0.2895
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0379 0.0295 0.0292
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0513 0.0409 0.538
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0176 0.2226
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0507 0.0405 0.5181
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0008 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0528 0.0422 0.5552
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0241 0.0176 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.053 0.0424 0.5581
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0524 0.0419 0.55
Trichomonas vaginalis PIKK family atypical protein kinase 0.0507 0.0405 0.532
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0184 0.0127 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0184 0.0127 0.1653
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0241 0.0176 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.0127 0.6454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Loa Loa (eye worm) hypothetical protein 0.034 0.0261 0.3436
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0241 0.0176 0.2236
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0005 0.0086
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0507 0.0405 0.1158
Echinococcus multilocularis Zinc finger, PHD finger 0.0241 0.0176 0.0173
Mycobacterium ulcerans lipase LipD 0.0041 0.0005 0.0994
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0184 0.0127 0.0124
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0205 0.0145 0.1877
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0241 0.0176 0.2247
Trichomonas vaginalis PIKK family atypical protein kinase 0.092 0.0759 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9739
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0313 0.0238 0.3025
Echinococcus granulosus neuropeptide receptor A26 0.0973 0.0804 0.0801
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0313 0.0238 0.3111
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.092 0.0759 0.9748
Brugia malayi hypothetical protein 0.0535 0.0428 0.5485
Loa Loa (eye worm) hypothetical protein 0.0184 0.0127 0.1679
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Brugia malayi beta-lactamase family protein 0.0041 0.0005 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Echinococcus multilocularis serine protein kinase ATM 0.0524 0.0419 0.0416
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.092 0.0759 0.0756
Loa Loa (eye worm) phosphatidylinositol 3 0.0743 0.0607 0.7999
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0008 0.0005
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0507 0.0405 0.0402
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0184 0.0127 0.0358
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.002 0.0262
Toxoplasma gondii FATC domain-containing protein 0.0524 0.0419 0.5582
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0112 0.2539
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0524 0.0419 0.1199
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0814 0.0668 0.8579
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0127 0.1669
Loa Loa (eye worm) hypothetical protein 0.0061 0.0022 0.0289
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0005 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Echinococcus multilocularis geminin 0.0873 0.0718 0.0716
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.002 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.0247 0.3231
Schistosoma mansoni inositol monophosphatase 0.0045 0.0008 0.0058
Mycobacterium leprae Probable lipase LipE 0.0041 0.0005 0.0134
Loa Loa (eye worm) cytochrome P450 0.0039 0.0003 0.0041
Leishmania major cytochrome p450-like protein 0.0059 0.002 0.0046
Brugia malayi Cytochrome P450 family protein 0.0059 0.002 0.0216
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0622 0.0503 0.1442
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0005 0.0086
Brugia malayi MH2 domain containing protein 0.0144 0.0093 0.116
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0008 0.0013
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0241 0.0176 0.2302
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0005 0.0002
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0814 0.0668 0.0665
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0004 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0528 0.0422 0.5552
Entamoeba histolytica protein kinase rad3, putative 0.0507 0.0405 0.5287
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0004 0.0041
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0184 0.0127 0.1603
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.002 0.0048
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0184 0.0127 0.0124
Schistosoma mansoni lozenge 0.0067 0.0027 0.0307
Leishmania major phosphatidylinositol 3-kinase, putative 0.0241 0.0176 0.0478
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0313 0.0238 0.3062
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0524 0.0419 0.5505
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.092 0.0759 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0541 0.0433 0.5698
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0331 0.4236
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Loa Loa (eye worm) hypothetical protein 0.0422 0.0331 0.4369
Entamoeba histolytica hypothetical protein 0.0184 0.0127 0.1594
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0622 0.0503 0.645
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.1645
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0008 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.092 0.0759 0.9748
Toxoplasma gondii target of rapamycin (TOR), putative 0.0907 0.0748 1
Brugia malayi Fli-1 protein 0.0218 0.0156 0.1973
Loa Loa (eye worm) fli-1 protein 0.0218 0.0156 0.2056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.024 0.0176 0.2226
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0008 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Loa Loa (eye worm) hypothetical protein 0.0563 0.0453 0.5968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9739
Schistosoma mansoni hypothetical protein 0.0041 0.0005 0.002
Mycobacterium tuberculosis Conserved protein 0.0041 0.0005 0.0086
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0005 0.0134
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0943 0.0778 0.2236
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0184 0.0127 0.0124
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0005 0.0994
Loa Loa (eye worm) beta-lactamase 0.0041 0.0005 0.0063
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0814 0.0668 0.0665
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0513 0.0409 0.538
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0176 0.05
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0176 0.2226
Leishmania major phosphatidylinositol kinase related protein, putative 0.02 0.0141 0.0381
Loa Loa (eye worm) hypothetical protein 0.0535 0.0428 0.5645
Schistosoma mansoni hypothetical protein 0.0873 0.0718 0.9231
Brugia malayi Inositol-1 0.0045 0.0008 0.0058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0021 0.0277
Onchocerca volvulus 0.0184 0.0127 0.2895
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0005 0.0994
Leishmania major hypothetical protein, unknown function 0.0184 0.0127 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Trypanosoma brucei target of rapamycin kinase 3, putative 0.091 0.075 0.9884
Loa Loa (eye worm) hypothetical protein 0.0535 0.0428 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.0127 0.1653
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.092 0.0759 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0241 0.0176 0.2302
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0313 0.0238 0.3111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.02 0.0141 0.1858
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0176 0.0173
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0038 0.0447
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0184 0.0127 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.075 0.9884
Echinococcus granulosus geminin 0.0873 0.0718 0.0716
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0943 0.0778 1
Schistosoma mansoni hypothetical protein 0.0184 0.0127 0.1603
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.0127 0.1679
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.7143
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0507 0.0405 0.0402
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0093 0.1227
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0005 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.0415 0.5456
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0038 0.0035
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.0358
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0005 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.0295 0.3867
Trichomonas vaginalis PIKK family atypical protein kinase 0.092 0.0759 1
Schistosoma mansoni hypothetical protein 0.0379 0.0295 0.3763
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.091 0.075 0.206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9738
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.0127 0.1653
Plasmodium vivax hypothetical protein 0.0184 0.0127 0.7143
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0008 0.0013
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.1694 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0184 0.0127 0.1679
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0038 0.0035
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0008 0.006
Loa Loa (eye worm) hypothetical protein 0.0507 0.0405 0.5334
Loa Loa (eye worm) runx1 0.0067 0.0027 0.0355
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0899 0.074 0.9758
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.0196 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0124 0.0076 0.1001
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0184 0.0127 0.7143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9738
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0422 0.0331 0.0328
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0241 0.0176 0.2325
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.092 0.0759 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.073 0.9622
Mycobacterium leprae conserved hypothetical protein 0.0184 0.0127 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0507 0.0405 0.5181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0313 0.0238 0.3025
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0184 0.0127 0.0358
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0038 0.0401
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.092 0.0759 0.2084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0176 0.0173
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0551 0.0442 0.5782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0176 0.2226
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0563 0.0453 0.6039
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0005 0.0032
Giardia lamblia GTOR 0.092 0.0759 1
Leishmania major hypothetical protein, conserved 0.0041 0.0005 0.0005
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0038 0.0498
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0256 0.0189 0.097
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0008 0.2702
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0127 0.1669
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0192 0.0134 0.1693
Echinococcus multilocularis Protein lozenge 0.0067 0.0027 0.0024
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0128 0.008 0.0221
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0441 0.0348 0.3495
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.092 0.0759 0.2179
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0313 0.0238 0.3104
Trichomonas vaginalis PIKK family atypical protein kinase 0.09 0.0741 0.9768
Brugia malayi Ets-domain containing protein 0.0072 0.0031 0.0358
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0005 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0907 0.0748 0.9854
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.027 0.3497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.0472 0.6217
Loa Loa (eye worm) phosphatidylinositol kinase 0.0184 0.0127 0.1679
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.002 0.0262
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0031 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9738
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0313 0.0238 0.3111
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0241 0.0176 0.2236
Echinococcus multilocularis neuropeptide s receptor 0.0973 0.0804 0.0801
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0379 0.0295 0.0292
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0005 0.002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0241 0.0176 0.2302
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0622 0.0503 0.6621
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0241 0.0176 0.2327
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0031 0.0407
Mycobacterium tuberculosis Conserved protein 0.0041 0.0005 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0887 0.073 0.9622
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.012 0.1556
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0184 0.0127 0.7143
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0241 0.0176 0.0173
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0008 0.0061
Trypanosoma cruzi target of rapamycin kinase 3 0.091 0.075 0.2154
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0127 0.1669
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0187 0.2444
Loa Loa (eye worm) phosphatidylinositol 3 0.0128 0.008 0.105
Trypanosoma cruzi hypothetical protein, conserved 0.408 0.3469 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0005 0.0021
Echinococcus multilocularis neuropeptide receptor A26 0.0973 0.0804 0.0801
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0031 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0112 0.1454
Brugia malayi FAT domain containing protein 0.0379 0.0295 0.3763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.0739 0.9739

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.