Detailed information for compound 1251106

Basic information

Technical information
  • TDR Targets ID: 1251106
  • Name: 1-(4-methoxyphenyl)-N-[2-(methylcarbamoyl)phe nyl]-5-oxopyrrolidine-3-carboxamide
  • MW: 367.398 | Formula: C20H21N3O4
  • H donors: 2 H acceptors: 3 LogP: 1.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1ccccc1NC(=O)C1CC(=O)N(C1)c1ccc(cc1)OC
  • InChi: 1S/C20H21N3O4/c1-21-20(26)16-5-3-4-6-17(16)22-19(25)13-11-18(24)23(12-13)14-7-9-15(27-2)10-8-14/h3-10,13H,11-12H2,1-2H3,(H,21,26)(H,22,25)
  • InChiKey: XJZLDGUWXZTMFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-methoxyphenyl)-N-[2-(methylcarbamoyl)phenyl]-5-oxo-pyrrolidine-3-carboxamide
  • 1-(4-methoxyphenyl)-N-[2-(methylcarbamoyl)phenyl]-5-oxo-3-pyrrolidinecarboxamide
  • 5-keto-1-(4-methoxyphenyl)-N-[2-(methylcarbamoyl)phenyl]pyrrolidine-3-carboxamide
  • MLS000708497
  • SMR000287964
  • BAS 07549300

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0045 0.0549 0.1085
Loa Loa (eye worm) hypothetical protein 0.0032 0.0343 0.0478
Schistosoma mansoni importin beta-1 0.0032 0.0343 0.0468
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0343 0.2408
Echinococcus granulosus dna polymerase kappa 0.0019 0.0122 0.0119
Onchocerca volvulus 0.0045 0.0549 0.1085
Echinococcus granulosus dnaJ subfamily B 0.0457 0.7341 0.734
Echinococcus multilocularis myotubularin protein 13 0.0016 0.0069 0.009
Echinococcus multilocularis 0.0045 0.0549 0.0744
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1246 0.1223
Brugia malayi Protein-tyrosine phosphatase 0.0045 0.0549 0.076
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Schistosoma mansoni protein kinase 0.0162 0.2479 0.3377
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0066 0.0903 0.1226
Schistosoma mansoni hypothetical protein 0.0015 0.0063 0.0086
Echinococcus multilocularis protein kinase c epsilon type 0.0048 0.0602 0.0816
Trichomonas vaginalis AGC family protein kinase 0.0107 0.1573 0.1579
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0045 0.0549 0.0744
Trypanosoma brucei unspecified product 0.0013 0.0026 0.0018
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0043 0.0521 0.0705
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1246 0.1223
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0744
Onchocerca volvulus 0.0045 0.0549 0.1085
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.004 0.0465 0.0629
Brugia malayi hypothetical protein 0.0045 0.0549 0.076
Giardia lamblia Kinase, CMGC CDK 0.0048 0.061 0.3359
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0243 0.0131
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0343 0.2166
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0602 0.0821
Echinococcus multilocularis serine:threonine protein kinase N2 0.0036 0.0412 0.0556
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.1252 0.7955
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.061 0.0848
Brugia malayi Protein kinase domain containing protein 0.0036 0.0412 0.0568
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0015 0.0063 0.006
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0053 0.0692 0.3824
Entamoeba histolytica protein kinase, putative 0.0036 0.0412 0.0439
Entamoeba histolytica protein kinase, putative 0.0043 0.0521 0.0556
Schistosoma mansoni protein kinase 0.0043 0.0521 0.0709
Schistosoma mansoni ran 0.0024 0.0203 0.0277
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0045 0.0549 0.0748
Entamoeba histolytica protein kinase, putative 0.0087 0.1246 0.1335
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.1351 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0045 0.0549 0.0546
Schistosoma mansoni hypothetical protein 0.0344 0.5478 0.7463
Trichomonas vaginalis STE family protein kinase 0.0022 0.0174 0.0056
Echinococcus granulosus rho-associated protein kinase 1 0.0148 0.2259 0.2256
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0546
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0208 0.3249 0.4519
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0045 0.0549 0.0744
Schistosoma mansoni protein tyrosine phosphatase 0.0045 0.0549 0.0748
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0059 0.0792 0.5454
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0465 0.0633
Brugia malayi Protein-tyrosine phosphatase 0.0045 0.0549 0.076
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0045 0.0549 0.0744
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Onchocerca volvulus 0.0045 0.0549 0.1085
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0019 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0045 0.0549 0.0546
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0147 0.0144
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0059 0.0792 0.0789
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0243 0.0131
Echinococcus granulosus cyclin dependent kinase 5 0.0048 0.061 0.0606
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0549 0.0748
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0093 0.1351 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.1252 1
Trypanosoma brucei cdc2-related kinase 3 0.0048 0.061 0.4415
Echinococcus granulosus snurportin 1 0.0344 0.5478 0.5476
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0317 0.5032 0.6854
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0003 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.061 0.0848
Schistosoma mansoni rac gtpase activating protein 0.0012 0.0003 0.0005
Onchocerca volvulus 0.0045 0.0549 0.1085
Trichomonas vaginalis ran, putative 0.0024 0.0203 0.0088
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.7341 1
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0028 0.027 0.0161
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0066 0.0903 0.09
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0043 0.0521 0.0705
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.5032 0.6855
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Onchocerca volvulus 0.0045 0.0549 0.1085
Onchocerca volvulus 0.0045 0.0549 0.1085
Echinococcus granulosus PAK box P21 Rho binding 0.0015 0.0063 0.006
Brugia malayi Protein kinase domain containing protein 0.0174 0.2678 0.3722
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0053 0.0692 0.0689
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.1252 0.1702
Brugia malayi probable protein kinase 0.0124 0.1864 0.2589
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0053 0.0692 0.464
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.007 0.0096
Echinococcus multilocularis serine threonine protein kinase 0.0036 0.0412 0.0556
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Entamoeba histolytica protein kinase, putative 0.0093 0.1351 0.1447
Echinococcus granulosus serine:threonine kinase SAD 1 0.004 0.0465 0.0461
Echinococcus multilocularis hypothetical protein 0.0045 0.0549 0.0744
Brugia malayi Protein kinase domain containing protein 0.0093 0.1351 0.1875
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0122 0.0162
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0203 0.02
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0174 0.2678 0.2675
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Trypanosoma cruzi SNF1-related protein kinases, putative 0.004 0.0465 0.2788
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Giardia lamblia Kinase, STE STE20 0.0043 0.0521 0.2747
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0059 0.0792 0.1079
Schistosoma mansoni serine/threonine-protein kinase 0.0057 0.0758 0.1033
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0343 0.0463
Brugia malayi p70 ribosomal S6 kinase beta 0.0083 0.118 0.1638
Schistosoma mansoni serine/threonine protein kinase 0.019 0.2949 0.4017
Echinococcus granulosus cyclin dependent kinase 0.0048 0.061 0.0606
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Brugia malayi P21-Rho-binding domain containing protein 0.0015 0.0063 0.0083
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0047 0.0582 0.0578
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0182 0.2811 0.2808
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0744
Schistosoma mansoni hypothetical protein 0.0059 0.0792 0.1079
Echinococcus granulosus Protein kinase C brain isozyme 0.0048 0.0602 0.0599
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0078 0.1093 0.1516
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0549 0.0748
Trypanosoma brucei cdc2-related kinase 1 0.0048 0.061 0.4415
Loa Loa (eye worm) hypothetical protein 0.0087 0.1252 0.1742
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Onchocerca volvulus 0.0148 0.2259 0.4484
Echinococcus multilocularis cyclin dependent kinase 5 0.0048 0.061 0.0826
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0122 0.017
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0119
Echinococcus granulosus serine:threonine protein kinase N2 0.0036 0.0412 0.0408
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0549 0.0748
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0045 0.0549 0.3476
Loa Loa (eye worm) hypothetical protein 0.0036 0.041 0.057
Echinococcus granulosus serine:threonine protein kinase TAO1 0.019 0.2949 0.2946
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0003 0.0005
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0107 0.1573 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0092 0.1333 0.1428
Trichomonas vaginalis STE family protein kinase 0.0043 0.0521 0.0434
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0122 0.0128
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0045 0.0549 0.0744
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Onchocerca volvulus 0.0045 0.0549 0.1085
Brugia malayi Temporarily assigned gene name protein 59 0.0125 0.1875 0.2604
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.0165
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0317 0.5032 0.6999
Brugia malayi hypothetical protein 0.0033 0.0354 0.0488
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0047 0.0582 0.0809
Entamoeba histolytica PH domain containing protein kinase, putative 0.0057 0.0758 0.0811
Loa Loa (eye worm) hypothetical protein 0.0033 0.0354 0.0492
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0122 0.0742
Schistosoma mansoni cpg binding protein 0.0032 0.0341 0.0465
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0147 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.1869 0.2546
Schistosoma mansoni rap gtpase-activating protein 0.0059 0.0792 0.1079
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Loa Loa (eye worm) hypothetical protein 0.0087 0.124 0.1725
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0934 0.1272
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0036 0.0412 0.0556
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0028 0.027 0.0376
Loa Loa (eye worm) hypothetical protein 0.0448 0.7188 1
Echinococcus multilocularis nervana 2 0.0047 0.0581 0.0788
Brugia malayi CXXC zinc finger family protein 0.0032 0.0341 0.047
Brugia malayi hypothetical protein 0.0045 0.0549 0.076
Leishmania major GTP-binding protein, putative 0.0024 0.0203 0.0659
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0125 0.1869 0.2542
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.061 0.083
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0317 0.5032 1
Trichomonas vaginalis STE family protein kinase 0.0043 0.0521 0.0434
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.061 0.0651
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0048 0.061 0.3967
Echinococcus multilocularis 0.0065 0.0884 0.12
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Brugia malayi P21-Rho-binding domain containing protein 0.0015 0.0063 0.0083
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0203 0.0394
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0028 0.027 0.0376
Echinococcus granulosus myotubularin protein 13 0.0016 0.0069 0.0066
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0756 0.0753
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0093 0.1351 0.1879
Giardia lamblia Kinase, NEK 0.0107 0.1573 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.061 0.0826
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0203 0.0278
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0203 0.0283
Loa Loa (eye worm) protein tyrosine phosphatase 0.0045 0.0549 0.0764
Loa Loa (eye worm) hypothetical protein 0.0087 0.124 0.1725
Entamoeba histolytica hypothetical protein 0.0015 0.0063 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.004 0.0465 0.2788
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0465 0.0633
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1246 0.1223
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0125 0.1869 0.1866
Schistosoma mansoni protein kinase 0.0022 0.0174 0.0237
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Echinococcus granulosus importin subunit beta 1 0.0032 0.0343 0.034
Echinococcus multilocularis rho associated protein kinase 0.0148 0.2259 0.3074
Entamoeba histolytica protein kinase, putative 0.0093 0.1351 0.1447
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0048 0.0602 0.0838
Schistosoma mansoni vav2 0.0016 0.0069 0.0095
Brugia malayi RNA, U transporter 1 0.0092 0.1322 0.1835
Brugia malayi Protein kinase domain containing protein 0.041 0.6566 0.9134
Onchocerca volvulus 0.0045 0.0549 0.1085
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0047 0.0581 0.0578
Schistosoma mansoni unc-13 (munc13) 0.0012 0.0003 0.0005
Brugia malayi cell division control protein 2 homolog 0.0048 0.061 0.0844
Giardia lamblia Kinase, NEK 0.0107 0.1573 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0122 0.0162
Onchocerca volvulus 0.0045 0.0549 0.1085
Trypanosoma brucei unspecified product 0.0019 0.0122 0.0742
Plasmodium falciparum NIMA related kinase 1 0.0107 0.1573 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0045 0.0549 0.0744
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0412 0.0315
Onchocerca volvulus 0.0071 0.0982 0.1946
Schistosoma mansoni cpg binding protein 0.0034 0.0371 0.0506
Echinococcus granulosus Vam6:Vps39 protein 0.0059 0.0792 0.0789
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.061 0.053
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0344 0.5478 0.7621
Brugia malayi Protein kinase domain containing protein 0.0036 0.0412 0.0568
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0078 0.1093 0.152
Brugia malayi Doublecortin family protein 0.0121 0.1807 0.2511
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0744
Loa Loa (eye worm) hypothetical protein 0.0033 0.0354 0.0492
Giardia lamblia Kinase, CAMK CAMKL 0.004 0.0465 0.2361
Brugia malayi Protein kinase domain containing protein 0.0448 0.7188 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0549 0.0748
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0182 0.2811 0.3826
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Echinococcus multilocularis cyclin dependent kinase 0.0048 0.061 0.0826
Schistosoma mansoni serine/threonine kinase 0.0036 0.0412 0.0561
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.1252 0.7749
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1351 0.184
Loa Loa (eye worm) hypothetical protein 0.0042 0.0499 0.0694
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0162 0.2476 0.2473
Onchocerca volvulus 0.0045 0.0549 0.1085
Schistosoma mansoni protein kinase 0.0124 0.1864 0.2539
Echinococcus multilocularis rac serine:threonine kinase 0.0057 0.0758 0.1029
Brugia malayi Probable ClpP-like protease 0.0087 0.1252 0.1738
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Echinococcus granulosus serine threonine protein kinase nrc 0.0053 0.0692 0.0689
Trypanosoma brucei unspecified product 0.0013 0.0026 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0742
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0742
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0546
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0147 0.0929
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0093 0.1351 1
Echinococcus multilocularis dual specificity 0.0093 0.1351 0.1836
Schistosoma mansoni plexin 0.002 0.0134 0.0183
Trypanosoma brucei SNF1-related protein kinases, putative 0.004 0.0465 0.3324
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0412 0.0315
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0756 0.4744
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0412 0.0561
Onchocerca volvulus 0.0045 0.0549 0.1085
Brugia malayi Temporarily assigned gene name protein 59 0.0059 0.0792 0.1098
Brugia malayi C1-like domain containing protein 0.0078 0.1093 0.1516
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0203 0.0272
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0045 0.0549 0.0744
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0045 0.0549 0.076
Toxoplasma gondii histone kinase SNF1, putative 0.004 0.0465 0.2939
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0122 0.0167
Schistosoma mansoni vam6/vps39 related 0.0059 0.0792 0.1079
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.061 0.053
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0546
Entamoeba histolytica hypothetical protein 0.0093 0.1351 0.1447
Plasmodium vivax importin-beta 2, putative 0.0032 0.0343 0.1377
Trypanosoma cruzi p21-activated kinase 3, putative 0.0028 0.027 0.1203
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0043 0.0521 0.0517
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.1869 0.2546
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0602 0.0821
Onchocerca volvulus 0.0045 0.0549 0.1085
Entamoeba histolytica hypothetical protein 0.0015 0.0063 0.0064
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0341 0.0475
Onchocerca volvulus 0.0045 0.0549 0.1085
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.004 0.0465 0.2788
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Entamoeba histolytica protein kinase 2, putative 0.0053 0.0692 0.074
Brugia malayi hypothetical protein 0.019 0.2949 0.4099
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.1252 0.1705
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0045 0.0549 0.0764
Echinococcus multilocularis plexin a4 0.0023 0.0193 0.0259
Schistosoma mansoni protein kinase 0.0043 0.0521 0.0709
Schistosoma mansoni atypical protein kinase C 0.0048 0.0602 0.0821
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0045 0.0549 0.0748
Schistosoma mansoni protein tyrosine phosphatase 0.0045 0.0549 0.0748
Echinococcus multilocularis nervana 2 0.0047 0.0581 0.0788
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1246 0.1223
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.1351 0.1447
Echinococcus granulosus Glutaredoxin protein 5 0.0047 0.0581 0.0578
Brugia malayi hypothetical protein 0.0045 0.0549 0.076
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.061 0.053
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0003 0.0005
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0107 0.1573 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0092 0.1333 0.1428
Echinococcus granulosus protein kinase c epsilon type 0.0048 0.0602 0.0599
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.027 0.0368
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0174 0.2678 0.3645
Onchocerca volvulus 0.0142 0.2148 0.4264
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0147 0.0027
Plasmodium falciparum serine/threonine protein kinase KIN 0.004 0.0465 0.2229
Schistosoma mansoni ap endonuclease 0.002 0.0147 0.02
Echinococcus multilocularis serine:threonine protein kinase 38 0.0036 0.0412 0.0556
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Schistosoma mansoni serine/threonine-protein kinase 0.0057 0.0758 0.1033
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0546
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1698 0.2313
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Brugia malayi Protein kinase domain containing protein 0.0134 0.2016 0.2801
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0012 0.0003 0.0005
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0022 0.0174 0.0242
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0036 0.0412 0.0408
Brugia malayi Hr1 repeat family protein 0.0036 0.0412 0.0568
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0053 0.0692 0.3824
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Plasmodium falciparum importin beta, putative 0.0032 0.0343 0.1377
Onchocerca volvulus 0.0045 0.0549 0.1085
Echinococcus granulosus cyclin dependent kinase 1 0.0048 0.061 0.0606
Schistosoma mansoni protein kinase 0.0174 0.2678 0.3648
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.1252 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0182 0.2811 0.391
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.004 0.0465 0.0647
Schistosoma mansoni ap endonuclease 0.002 0.0147 0.02
Echinococcus multilocularis cpg binding protein 0.0034 0.0371 0.0501
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0036 0.0412 0.0573
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0043 0.0521 0.0705
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0744
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0162
Brugia malayi Importin beta-1 subunit 0.0032 0.0343 0.0473
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0203 0.0558
Onchocerca volvulus 0.0059 0.0791 0.1566
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Trichomonas vaginalis STE family protein kinase 0.0043 0.0521 0.0434
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0045 0.0549 0.3476
Schistosoma mansoni ran 0.0024 0.0203 0.0277
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.1252 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.0097
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.004 0.0465 0.2229
Onchocerca volvulus 4.1 G protein, putative homolog 0.0045 0.0549 0.1085
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0546
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0162 0.2479 0.3448
Brugia malayi WH1 domain containing protein 0.0015 0.0063 0.0083
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0045 0.0549 0.0744
Giardia lamblia Kinase, CAMK CAMKL 0.004 0.0465 0.2361
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0045 0.0549 0.0546
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0045 0.0549 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0018
Plasmodium falciparum protein kinase 5 0.0048 0.061 0.3244
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0059 0.0792 0.5791
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0309 0.1133
Onchocerca volvulus 0.0059 0.0792 0.1568
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0756 0.1026
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0043 0.0521 0.0517
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0744
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.061 0.083
Echinococcus granulosus protein tyrosine phosphatase n9 0.0045 0.0549 0.0546
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0045 0.0549 0.0748
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0036 0.0412 0.0556
Giardia lamblia Kinase, AGC PKA 0.0053 0.0692 0.3929
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0343 0.2408
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0465 0.0633
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0048 0.061 0.3967
Onchocerca volvulus 0.0075 0.1048 0.2077
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0066 0.0902 0.1255
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0162 0.2476 0.3369
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Entamoeba histolytica protein kinase, putative 0.0022 0.0174 0.0183
Trypanosoma brucei rac serine-threonine kinase, putative 0.0087 0.1246 0.9214
Echinococcus granulosus dual specificity 0.0093 0.1351 0.1348
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.041 0.6566 0.9135
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.004 0.0465 0.0647
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0045 0.0549 0.0744
Entamoeba histolytica protein kinase, putative 0.0083 0.118 0.1265
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Brugia malayi protein kinase C II. 0.0048 0.0602 0.0834
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0317 0.5032 0.5031
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0045 0.0549 0.0764
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Echinococcus granulosus protein kinase 0.0065 0.0884 0.0881
Toxoplasma gondii hypothetical protein 0.003 0.0309 0.1944
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0744
Echinococcus granulosus plexin a4 0.0023 0.0193 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0115 0.1714 0.2385
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0045 0.0549 0.0748
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0147 0.02
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0243 0.0131
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0045 0.0549 0.0744
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0549 0.0748
Onchocerca volvulus 0.0045 0.0549 0.1085
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0465 0.0633
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0744
Echinococcus multilocularis PAK box P21 Rho binding 0.0015 0.0063 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0028 0.027 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.061 0.3967
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0048 0.0602 0.0816
Giardia lamblia Protein tyrosine phosphatase 0.0045 0.0549 0.2944
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0814 0.5165
Brugia malayi Protein kinase domain 0.0043 0.0521 0.072
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.004 0.0465 0.3324
Schistosoma mansoni hypothetical protein 0.0457 0.7341 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.1252 0.5
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0015 0.0063 0.0086
Brugia malayi Serine/threonine-protein kinase SULU 0.019 0.2949 0.4099
Schistosoma mansoni protein kinase 0.0162 0.2476 0.3372
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.1252 0.7749
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Brugia malayi plexin A 0.0023 0.0193 0.0264
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0048 0.061 0.0848
Loa Loa (eye worm) AGC/PKN protein kinase 0.0036 0.0412 0.0573
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Loa Loa (eye worm) hypothetical protein 0.0092 0.1333 0.1854
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0045 0.0549 0.0586
Schistosoma mansoni protein kinase 0.0162 0.2476 0.3372
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0412 0.0315
Loa Loa (eye worm) AGC/NDR protein kinase 0.0036 0.0412 0.0573
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0309 0.1133
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1246 0.1223
Schistosoma mansoni protein kinase 0.0015 0.0063 0.0086
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0059 0.0792 0.5454
Onchocerca volvulus 0.0045 0.0549 0.1085
Loa Loa (eye worm) hypothetical protein 0.0036 0.0412 0.0573
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.004 0.0465 0.2788
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.041 0.0313
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.1252 0.7955
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0744
Loa Loa (eye worm) hypothetical protein 0.0059 0.0792 0.1102
Toxoplasma gondii exonuclease III APE 0.002 0.0147 0.0915
Onchocerca volvulus 0.002 0.0134 0.026
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0412 0.0561
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0147 0.039
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0546
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0147 0.0196
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0744
Echinococcus multilocularis PAK box P21 Rho binding 0.0022 0.0174 0.0233
Schistosoma mansoni pcd6 interacting protein-related 0.0045 0.0549 0.0748
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0021 0.0159 0.0156
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0147 0.0201
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0045 0.0549 0.0764
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0047 0.0581 0.0788
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0203 0.1352
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0546
Brugia malayi Protein kinase domain containing protein 0.0087 0.1246 0.173
Brugia malayi protein kinase C3,putative 0.0018 0.0114 0.0154
Trichomonas vaginalis AGC family protein kinase 0.004 0.0478 0.0387
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Trichomonas vaginalis STE family protein kinase 0.0043 0.0521 0.0434
Loa Loa (eye worm) hypothetical protein 0.004 0.0465 0.0647
Echinococcus multilocularis serine:threonine protein kinase N2 0.0036 0.0412 0.0556
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Trypanosoma brucei protein tyrosine phosphatase 1 0.0045 0.0549 0.3961
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0028 0.027 0.1203
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0317 0.5032 0.7001
Schistosoma mansoni hypothetical protein 0.0015 0.0063 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.061 0.0826
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0147 0.0201
Brugia malayi Protein kinase c protein 2 0.0018 0.0114 0.0154
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0048 0.061 0.0606
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0203 0.1273
Brugia malayi hypothetical protein 0.0059 0.0792 0.1098
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0147 0.0027
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0309 0.1461
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0147 0.0154
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Leishmania major importin beta-1 subunit, putative 0.0026 0.0243 0.0982
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0045 0.0549 0.0748
Echinococcus granulosus nervana 2 0.0047 0.0581 0.0578
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Echinococcus granulosus serine/threonine protein kinase 0.0057 0.0758 0.0755
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0121 0.1807 0.2514
Schistosoma mansoni protein kinase 0.0065 0.0884 0.1204
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0015 0.0063 0.0082
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0122 0.017
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0018 0.0114 0.0159
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.1252 0.1249
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0602 0.0821
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0454 0.7299 0.7298
Loa Loa (eye worm) hypothetical protein 0.0071 0.0982 0.1366
Loa Loa (eye worm) hypothetical protein 0.0059 0.0791 0.1101
Schistosoma mansoni tyrosine kinase 0.0019 0.013 0.0177
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0147 0.0201
Echinococcus multilocularis raf serine:threonine protein kinase 0.0016 0.007 0.0091
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0045 0.0549 0.0748
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.003 0.0301 0.0194
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0448 0.7188 1
Plasmodium vivax protein kinase Crk2 0.0048 0.061 0.3244
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0053 0.0692 0.0939
Echinococcus granulosus protein kinase c iota type 0.0048 0.0602 0.0599
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0057 0.0758 0.5177
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Leishmania major tyrosine specific protein phosphatase, putative 0.0045 0.0549 0.3476
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.013 0.0177
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0047 0.0582 0.0788
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0412 0.0561
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0045 0.0549 0.3476
Echinococcus multilocularis Glutaredoxin protein 5 0.0047 0.0581 0.0788
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0546
Loa Loa (eye worm) hypothetical protein 0.0118 0.1753 0.2438
Schistosoma mansoni protein kinase C 0.0012 0.0003 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.2259 0.3077
Schistosoma mansoni protein tyrosine phosphatase 0.0045 0.0549 0.0748
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.004 0.0465 0.0461
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0742
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.004 0.0465 0.0642
Entamoeba histolytica Ran family GTPase 0.0024 0.0203 0.0215
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.019 0.2949 0.4014
Echinococcus granulosus dna polymerase eta 0.0019 0.0122 0.0119
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0059 0.0792 0.1075
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0546
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0203 0.0394
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0454 0.7299 0.9943
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0045 0.0549 0.0748
Onchocerca volvulus 0.0045 0.0549 0.1085
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0122 0.0167
Brugia malayi Pleckstrin Homology Domain 0.0016 0.0069 0.0092
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.1351 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0546
Schistosoma mansoni DNA polymerase eta 0.0019 0.0122 0.0167
Trypanosoma cruzi Protein kinase B 0.0057 0.0758 0.5177
Onchocerca volvulus 0.0045 0.0549 0.1085
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.027 0.0368
Brugia malayi Protein kinase domain containing protein 0.0317 0.5032 0.6999
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0045 0.0549 0.0586
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0756 1
Entamoeba histolytica p21-activated kinase 0.0047 0.0587 0.0627
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1246 0.1223
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0549 0.0546
Entamoeba histolytica PH domain containing protein kinase, putative 0.0057 0.0758 0.0811
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0744
Echinococcus granulosus cpg binding protein 0.0034 0.0371 0.0368
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Giardia lamblia Kinase, CMGC CDK 0.0048 0.061 0.3359
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0465 0.0373
Trichomonas vaginalis AGC family protein kinase 0.0087 0.1246 0.1223
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Onchocerca volvulus 0.0045 0.0549 0.1085
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Schistosoma mansoni protein kinase C mu 0.0012 0.0003 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0412 0.0561
Entamoeba histolytica protein kinase, putative 0.0087 0.1246 0.1335
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0036 0.0412 0.0573
Loa Loa (eye worm) hypothetical protein 0.0059 0.0792 0.1102
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0243 0.0982
Onchocerca volvulus 0.0032 0.0341 0.0672
Onchocerca volvulus 0.0045 0.0549 0.1085
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.2811 0.3829
Entamoeba histolytica serine/threonine protein kinase, putative 0.004 0.0465 0.0496
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0203 0.0659
Brugia malayi Protein-tyrosine phosphatase 1 0.0047 0.0582 0.0805
Onchocerca volvulus 0.0045 0.0549 0.1085
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0043 0.0521 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0018
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0756 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Entamoeba histolytica protein kinase, putative 0.0026 0.024 0.0254
Echinococcus granulosus nervana 2 0.0047 0.0581 0.0578
Echinococcus granulosus raf serine:threonine protein kinase 0.0016 0.007 0.0067
Echinococcus granulosus protein kinase C gamma type 0.0036 0.0412 0.0408
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Brugia malayi Plexin repeat family protein 0.002 0.0134 0.0182
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0576 0.931 1
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0045 0.0549 0.3476
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0048 0.061 0.3862
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0187
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0576 0.931 1
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0065 0.0884 0.123
Trichomonas vaginalis pten, drome, putative 0.0045 0.0549 0.0465
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Loa Loa (eye worm) hypothetical protein 0.0045 0.0549 0.0764
Loa Loa (eye worm) hypothetical protein 0.0059 0.0792 0.1102
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0015 0.0063 0.006
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0045 0.0549 0.0748
Echinococcus granulosus NDR protein kinase 0.0036 0.0412 0.0408
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0015 0.0063 0.0088
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0036 0.0412 0.0556
Schistosoma mansoni protein kinase C mu 0.0078 0.1093 0.1489
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0147 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0005
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0317 0.5032 0.7001
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0015 0.0063 0.0086
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0059 0.0792 0.1079
Brugia malayi serine/threonine-protein kinase PAK 7 0.0022 0.0174 0.0238
Brugia malayi Protein kinase domain containing protein 0.0048 0.061 0.0844
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0036 0.0412 0.0408
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.019 0.2949 0.4102
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0045 0.0549 0.0744
Giardia lamblia Kinase, NEK 0.0107 0.1573 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0036 0.0412 0.0408
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0549 0.0764
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0549 0.076
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.061 0.3967
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0045 0.0549 0.0748
Entamoeba histolytica hypothetical protein 0.0026 0.0243 0.0257
Entamoeba histolytica protein kinase, putative 0.0026 0.024 0.0254
Brugia malayi hypothetical protein 0.0045 0.0549 0.076
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0045 0.0549 0.0744
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0083 0.118 0.1642
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0203 0.0659
Brugia malayi putative serine/threonine kinase SADA gamma 0.004 0.0465 0.0642
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.1252 1
Trichomonas vaginalis STE family protein kinase 0.0107 0.1573 0.1579
Brugia malayi Protein kinase domain containing protein 0.0162 0.2479 0.3445
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0742
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0003 0.0005
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0118 0.1753 0.175
Loa Loa (eye worm) AGC/AKT protein kinase 0.0087 0.1246 0.1734
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0174 0.2678 0.3725
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0045 0.0549 0.0586
Entamoeba histolytica cell division protein kinase 2, putative 0.0048 0.061 0.0651
Loa Loa (eye worm) plexin A 0.0023 0.0193 0.0269
Onchocerca volvulus 0.0045 0.0549 0.1085
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0018
Trypanosoma cruzi cdc2-related kinase 1 0.0048 0.061 0.3967
Echinococcus multilocularis protein kinase c iota type 0.0048 0.0602 0.0816
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.1252 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0791 0.1101
Schistosoma mansoni cpg binding protein 0.0034 0.0371 0.0506
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.1252 1
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0465 0.0633
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0147 0.0219
Echinococcus multilocularis serine:threonine kinase SAD 1 0.004 0.0465 0.0629
Brugia malayi map kinase activated protein kinase protein 2 0.0182 0.2811 0.3907
Echinococcus multilocularis snurportin 1 0.0344 0.5478 0.7461
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0045 0.0549 0.076
Loa Loa (eye worm) raf kinase 0.0012 0.0003 0.0005
Trypanosoma cruzi cdc2-related kinase 3 0.0048 0.061 0.3967
Toxoplasma gondii AGC kinase 0.0083 0.118 0.7499
Schistosoma mansoni unc-13 (munc13) 0.0012 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0075 0.1048 0.1458
Brugia malayi hypothetical protein 0.0045 0.0549 0.076
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0549 0.0546

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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