Detailed information for compound 1272775

Basic information

Technical information
  • TDR Targets ID: 1272775
  • Name: methyl (Z,5R,6S,7Z)-7-[2-[(2S,5S,6R)-5-acetyl oxy-6-(acetyloxymethyl)-5,6-dihydro-2H-pyran- 2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl )sulfonylamino]hept-3-enoate
  • MW: 594.674 | Formula: C28H38N2O10S
  • H donors: 1 H acceptors: 5 LogP: 2.85 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)C/C=C\[C@H]([C@H](NS(=O)(=O)c1ccc(cc1)C)/C=N\OCC[C@H]1C=C[C@@H]([C@H](O1)COC(=O)C)OC(=O)C)C
  • InChi: 1S/C28H38N2O10S/c1-19-9-12-24(13-10-19)41(34,35)30-25(20(2)7-6-8-28(33)36-5)17-29-38-16-15-23-11-14-26(39-22(4)32)27(40-23)18-37-21(3)31/h6-7,9-14,17,20,23,25-27,30H,8,15-16,18H2,1-5H3/b7-6-,29-17-/t20-,23-,25-,26+,27-/m1/s1
  • InChiKey: WTZHDRHPQXYAKQ-RBXALEHYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (Z,5R,6S,7Z)-7-[2-[(2S,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoate
  • (Z,5R,6S,7Z)-7-[2-[(2S,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi putative serine/threonine kinase SADA gamma 0.0037 0.0089 0.0089
Toxoplasma gondii preprocathepsin c precursor, putative 0.0657 0.3596 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0036 0.0084 0.0263
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0027 0.0034 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0205 0.0915
Onchocerca volvulus Tyrosine kinase homolog 0.0421 0.226 0.7089
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0883 0.4024
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.1308
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0194 0.0978 0.7566
Giardia lamblia Kinase, CMGC GSK 0.0249 0.129 0.3578
Brugia malayi cyclin-dependent kinase 9 0.006 0.0218 0.0218
Plasmodium vivax serine/threonine kinase-1, putative 0.0136 0.0648 0.1789
Schistosoma mansoni cell adhesion molecule 0.0036 0.0084 0.0233
Echinococcus granulosus protein kinase shaggy 0.0249 0.129 0.4048
Entamoeba histolytica protein kinase, putative 0.0194 0.0978 0.7566
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0693 0.1927
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0027 0.0034 0.0073
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0095 0.0417 0.3199
Loa Loa (eye worm) hypothetical protein 0.0043 0.0123 0.0123
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0249 0.129 1
Trypanosoma brucei aurora B kinase 0.0177 0.0883 0.6829
Entamoeba histolytica protein kinase, putative 0.0029 0.0044 0.0293
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0546 0.2968 0.2968
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0089 0.0383 0.0383
Plasmodium falciparum protein kinase 5 0.0057 0.0205 0.0555
Echinococcus multilocularis casein kinase I delta 0.0052 0.0176 0.0383
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0009 0.0009
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0247 0.1278 0.2776
Loa Loa (eye worm) AGC/PKA protein kinase 0.0095 0.0417 0.0417
Echinococcus granulosus epidermal growth factor receptor 0.0243 0.1253 0.3929
Brugia malayi hypothetical protein 0.0026 0.0028 0.0028
Echinococcus multilocularis sodium and chloride dependent glycine 0.0163 0.0805 0.1747
Onchocerca volvulus 0.0032 0.006 0.0189
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Entamoeba histolytica protein kinase domain containing protein 0.0249 0.129 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Toxoplasma gondii AGC kinase 0.0095 0.0417 0.1138
Brugia malayi Protein kinase domain containing protein 0.0194 0.0978 0.0978
Echinococcus multilocularis rho associated protein kinase 0.0585 0.3188 0.6922
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0194 0.0978 0.7566
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0009 0.0008
Schistosoma mansoni protein kinase 0.0182 0.0912 0.2535
Echinococcus granulosus casein kinase I alpha 0.0052 0.0176 0.0553
Onchocerca volvulus 0.0026 0.0028 0.0089
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0095 0.0417 0.3199
Brugia malayi Protein kinase domain containing protein 0.0022 0.0006 0.0006
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0177 0.0883 0.277
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0032 0.006 0.0131
Schistosoma mansoni protein kinase 0.0052 0.0176 0.0491
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0249 0.129 0.3573
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0092 0.0399 0.0399
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0036 0.0086 0.0086
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0131 0.062 0.062
Brugia malayi serine/threonine-protein kinase PAK 7 0.0546 0.2968 0.2968
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0095 0.0417 0.3199
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0205 0.0571
Brugia malayi Cell division protein kinase 2 0.0022 0.0006 0.0006
Loa Loa (eye worm) TK/INSR protein kinase 0.0148 0.0717 0.0717
Plasmodium falciparum protein serine/threonine kinase-1 0.0136 0.0648 0.1789
Trypanosoma brucei protein kinase, putative 0.0026 0.0026 0.0157
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0009 0.0022
Onchocerca volvulus 0.0026 0.0028 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0247 0.1278 0.3555
Schistosoma mansoni tyrosine kinase 0.0231 0.1187 0.3302
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0205 0.0915
Echinococcus multilocularis sodium and chloride dependent glycine 0.0163 0.0805 0.1747
Loa Loa (eye worm) hypothetical protein 0.018 0.0897 0.0897
Trypanosoma cruzi cdc2-related kinase 1 0.0057 0.0205 0.1552
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0034 0.0095
Brugia malayi P21-Rho-binding domain containing protein 0.0045 0.0137 0.0137
Schistosoma mansoni protein kinase 0.0089 0.0383 0.1066
Leishmania major protein kinase, putative 0.0026 0.0026 0.0157
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0657 0.3596 1
Onchocerca volvulus 0.0032 0.0059 0.0185
Plasmodium vivax glycogen synthase kinase 3, putative 0.0249 0.129 0.3578
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0026 0.0157
Schistosoma mansoni serine/threonine protein kinase 0.0478 0.2581 0.7177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0073 0.0293 0.0637
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0089 0.0383 0.2939
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0034 0.0095
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0648 0.2946
Echinococcus multilocularis cyclin dependent kinase 19 0.0146 0.0708 0.1537
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0249 0.129 0.3577
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0249 0.129 0.3577
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0032 0.006 0.5
Onchocerca volvulus 0.0249 0.129 0.4048
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0026 0.0026 0.0048
Echinococcus granulosus Immunoglobulin 0.0027 0.0034 0.0106
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0205 0.0915
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0032 0.006 0.0189
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0134 0.0638 0.0638
Toxoplasma gondii aurora kinase 0.0177 0.0883 0.2438
Trichomonas vaginalis CMGC family protein kinase 0.0249 0.129 0.5892
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.0417 0.3199
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus granulosus tyrosine protein kinase Blk 0.0026 0.0028 0.0089
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0136 0.0648 0.5
Brugia malayi casein kinase I 0.0052 0.0176 0.0176
Plasmodium vivax amine transporter, putative 0.0032 0.006 0.0151
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0045 0.0134 0.0358
Echinococcus multilocularis epidermal growth factor receptor 0.0243 0.1253 0.272
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0417 0.1885
Entamoeba histolytica p21-activated kinase 0.006 0.0218 0.1651
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.0905
Echinococcus granulosus dual specificity 0.0194 0.0978 0.3068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0028 0.0089
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0249 0.129 0.129
Loa Loa (eye worm) hypothetical protein 0.028 0.1461 0.1461
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0028 0.0062
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0073 0.0293 0.0293
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0638 0.1776
Echinococcus granulosus epidermal growth factor receptor 0.0444 0.239 0.7498
Trypanosoma cruzi cdc2-related kinase 3 0.0057 0.0205 0.1552
Loa Loa (eye worm) solute carrier family 6 member 4 0.0032 0.006 0.006
Echinococcus granulosus PAK box P21 Rho binding 0.0045 0.0137 0.0431
Leishmania major protein kinase A catalytic subunit 0.0095 0.0417 0.3199
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0086 0.037
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0057 0.0205 0.0205
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0177 0.0883 0.6829
Trichomonas vaginalis STE family protein kinase 0.0089 0.0383 0.1731
Schistosoma mansoni tyrosine kinase 0.0243 0.1253 0.3483
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0089 0.0383 0.0383
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0045 0.0137 0.0382
Loa Loa (eye worm) hypothetical protein 0.018 0.0897 0.0897
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0249 0.129 0.4048
Giardia lamblia Macrophage migration inhibitory factor 0.0036 0.0086 0.0224
Schistosoma mansoni vesicular amine transporter 0.0027 0.0034 0.0094
Echinococcus multilocularis tyrosine protein kinase Srms 0.0026 0.0028 0.0062
Schistosoma mansoni tyrosine kinase 0.0231 0.1187 0.3302
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0095 0.0417 0.3199
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0203 0.0564
Plasmodium falciparum serine/threonine protein kinase KIN 0.0037 0.0089 0.0233
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.006 0.0167
Brugia malayi SH2 domain containing protein 0.0026 0.0028 0.0028
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.1308
Schistosoma mansoni tyrosine kinase 0.0148 0.0717 0.1995
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.0143
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.006 0.0167
Echinococcus granulosus dual specificity protein kinase clk2 0.0136 0.0648 0.2033
Schistosoma mansoni protein kinase 0.006 0.0218 0.0606
Echinococcus multilocularis cyclin dependent kinase 5 0.0057 0.0205 0.0446
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0089 0.0249
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0177 0.0883 0.1918
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0148 0.0717 0.1557
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0134 0.0638 0.0638
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0032 0.006 0.0189
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0037 0.0089 0.0089
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0028 0.0062
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0194 0.0978 0.7566
Echinococcus granulosus activin receptor type 0.0026 0.0026 0.0082
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0028 0.0089
Schistosoma mansoni tyrosine kinase 0.0243 0.1253 0.3483
Brugia malayi Protein kinase domain containing protein 0.0146 0.0708 0.0708
Onchocerca volvulus 0.0038 0.0096 0.0301
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0026 0.0028 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0089 0.0249
Leishmania major protein kinase A catalytic subunit isoform 2 0.0095 0.0417 0.3199
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0194 0.0978 0.0978
Brugia malayi intracellular kinase 0.0249 0.129 0.129
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0478 0.2581 0.2581
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0045 0.0137 0.0137
Echinococcus multilocularis neuroglian 0.0034 0.0073 0.0158
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0146 0.0708 0.0708
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0137 0.0604
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0037 0.0089 0.065
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0057 0.0205 0.1552
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Brugia malayi WH1 domain containing protein 0.0045 0.0137 0.0137
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0134 0.0638 0.2003
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Onchocerca volvulus 0.0026 0.0028 0.0089
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0036 0.0086 0.0224
Onchocerca volvulus 0.0032 0.006 0.0189
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0036 0.0086 0.0086
Schistosoma mansoni tyrosine kinase 0.0231 0.1187 0.3302
Entamoeba histolytica protein kinase, putative 0.0177 0.0883 0.6829
Onchocerca volvulus 0.0585 0.3188 1
Echinococcus granulosus casein kinase I alpha 0.0052 0.0176 0.0553
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0883 0.2456
Giardia lamblia Kinase, CMGC CDK 0.0057 0.0205 0.0555
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0131 0.062 0.062
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.006 0.0167
Schistosoma mansoni serine/threonine kinase 0.0022 0.0006 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0009 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0417 0.1159
Echinococcus granulosus defective proboscis extension response 0.0027 0.0034 0.0106
Echinococcus granulosus serotonin transporter 0.0032 0.006 0.0189
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0249 0.129 0.129
Loa Loa (eye worm) haspin protein kinase 0.0022 0.0006 0.0006
Echinococcus granulosus sodium and chloride dependent glycine 0.0163 0.0805 0.2524
Brugia malayi casein kinase 1, delta 0.0052 0.0176 0.0176
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0109 0.0341
Echinococcus granulosus cyclin dependent kinase 0.0057 0.0205 0.0644
Entamoeba histolytica protein kinase , putative 0.0177 0.0883 0.6829
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0247 0.1278 0.1278
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0037 0.0089 0.0194
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0037 0.0089 0.065
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0095 0.0417 0.3199
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.0905
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.006 0.0218 0.0473
Treponema pallidum sodium- and chloride- dependent transporter 0.0032 0.006 1
Brugia malayi Protein kinase domain containing protein 0.0057 0.0205 0.0205
Echinococcus multilocularis tyrosine protein kinase Blk 0.0026 0.0028 0.0062
Echinococcus multilocularis casein kinase i 0.0052 0.0176 0.0383
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0009 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0045 0.0137 0.1024
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0009 0.0013
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0657 0.3596 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0178 0.0885 0.2461
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Brugia malayi hypothetical protein 0.0027 0.0034 0.0034
Entamoeba histolytica cell division protein kinase 2, putative 0.0065 0.025 0.1903
Echinococcus granulosus beta-adrenergic receptor kinase 0.0027 0.0034 0.0107
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0038 0.0096 0.0701
Echinococcus granulosus c-Jun N-terminal kinases 0.0247 0.1278 0.401
Schistosoma mansoni tyrosine kinase 0.0444 0.239 0.6647
Leishmania major macrophage migration inhibitory factor-like protein 0.0036 0.0086 0.0627
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0194 0.0978 0.7566
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0059 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0009 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Toxoplasma gondii cathepsin CPC2 0.0249 0.129 0.3572
Trypanosoma brucei cdc2-related kinase 1 0.0057 0.0205 0.1552
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0095 0.0417 0.0417
Plasmodium falciparum glycogen synthase kinase 3 0.0249 0.129 0.3578
Leishmania major protein kinase A catalytic subunit isoform 1 0.0095 0.0417 0.3199
Brugia malayi hypothetical protein 0.0023 0.0009 0.0009
Giardia lamblia Aurora kinase 0.0177 0.0883 0.2444
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0028
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.006 0.0167
Brugia malayi secreted modular calcium-binding protein 1 0.0032 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0382
Plasmodium vivax hypothetical protein, conserved 0.0032 0.006 0.0151
Echinococcus granulosus cyclin dependent kinase 9 0.0068 0.0263 0.0825
Entamoeba histolytica casein kinase 1, putative 0.0052 0.0176 0.1327
Echinococcus multilocularis roundabout 2 0.0043 0.0123 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0648 0.1803
Loa Loa (eye worm) AUR protein kinase 0.0177 0.0883 0.0883
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0095 0.0417 0.1145
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0478 0.2581 0.8095
Echinococcus multilocularis aurora kinase A 0.0177 0.0883 0.1918
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.0905
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0089 0.0383 0.2939
Echinococcus granulosus serine:threonine protein kinase NLK 0.0022 0.0006 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus multilocularis epidermal growth factor receptor 0.0444 0.239 0.519
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0978 0.272
Entamoeba histolytica protein kinase, putative 0.006 0.0218 0.1651
Schistosoma mansoni nephrin 0.0034 0.0073 0.0203
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0024
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0057 0.0205 0.1552
Onchocerca volvulus 0.0032 0.0059 0.0185
Giardia lamblia Kinase, STE STE20 0.006 0.0218 0.0591
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0026 0.0028 0.0062
Onchocerca volvulus 0.0402 0.2155 0.6762
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0136 0.0648 0.5
Plasmodium falciparum macrophage migration inhibitory factor 0.0036 0.0086 0.0224
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0136 0.0648 0.5
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0131 0.062 0.1944
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Entamoeba histolytica protein kinase, putative 0.0249 0.129 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0009 0.0019
Trypanosoma cruzi cdc2-related kinase 3 0.0057 0.0205 0.1552
Toxoplasma gondii hypothetical protein 0.0032 0.006 0.0143
Echinococcus granulosus casein kinase I delta 0.0052 0.0176 0.0553
Entamoeba histolytica protein kinase, putative 0.0194 0.0978 0.7566
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0657 0.3596 1
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0026 0.0028 0.0062
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0089 0.0249
Schistosoma mansoni sodium/chloride dependent transporter 0.0163 0.0805 0.2238
Echinococcus multilocularis cyclin dependent kinase 9 0.006 0.0218 0.0473
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0052 0.0176 0.0176
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.006
Brugia malayi Protein kinase domain containing protein 0.0478 0.2581 0.2581
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0131 0.062 0.062
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0177 0.0883 0.2444
Loa Loa (eye worm) TK/ALK protein kinase 0.0291 0.1527 0.1527
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0022 0.0006 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0218 0.0606
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.0417 0.3199
Brugia malayi serine/threonine kinase 12 0.0177 0.0883 0.0883
Onchocerca volvulus 0.0571 0.3107 0.9748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0095 0.0417 0.3199
Echinococcus multilocularis serotonin transporter 0.0032 0.006 0.0131
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0478 0.2581 0.2581
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.006 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0408 0.2186 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0032 0.006 0.0189
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0089 0.0383 0.2939
Echinococcus multilocularis casein kinase I alpha 0.0052 0.0176 0.0383
Entamoeba histolytica protein kinase domain containing protein 0.0026 0.0026 0.0157
Brugia malayi Protein kinase domain 0.006 0.0218 0.0218
Echinococcus multilocularis cyclin dependent kinase 1 0.0057 0.0205 0.0446
Echinococcus granulosus aurora kinase A 0.0177 0.0883 0.277
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0032 0.006 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Echinococcus multilocularis activin receptor type 0.0026 0.0026 0.0057
Echinococcus granulosus cyclin dependent kinase 19 0.0146 0.0708 0.222
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0136 0.0648 0.1783
Entamoeba histolytica hypothetical protein 0.0045 0.0137 0.1024
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0883 0.4024
Trichomonas vaginalis STE family protein kinase 0.0089 0.0383 0.1731
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0084
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.1308
Schistosoma mansoni tyrosine kinase 0.0057 0.0203 0.0564
Brugia malayi Fibronectin type III domain containing protein 0.0027 0.0034 0.0034
Schistosoma mansoni protein kinase 0.0045 0.0137 0.0382
Entamoeba histolytica protein kinase, putative 0.006 0.0218 0.1651
Schistosoma mansoni protein kinase 0.0177 0.0883 0.2456
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.006 0.0218 0.0684
Echinococcus multilocularis 0.0135 0.0641 0.1393
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Echinococcus multilocularis cyclin dependent kinase 1 0.0057 0.0205 0.0446
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0028 0.0062
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0478 0.2581 0.5603
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0136 0.0648 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0028 0.0062
Entamoeba histolytica casein kinase, putative 0.0052 0.0176 0.1327
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.006
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0026 0.0028 0.0062
Echinococcus multilocularis tyrosine protein kinase shark 0.0026 0.0028 0.0062
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0037 0.0089 0.065
Schistosoma mansoni tyrosine kinase 0.0148 0.0717 0.1995
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0009 0.0022
Loa Loa (eye worm) TK/KIN16 protein kinase 0.045 0.2424 0.2424
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0243 0.1253 0.3929
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Brugia malayi protein-tyrosine kinase 0.0026 0.0028 0.0028
Plasmodium falciparum casein kinase 1 0.0052 0.0176 0.0475
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0009 0.5
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0657 0.3596 1
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0045 0.0137 0.0431
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0057 0.0205 0.0205
Brugia malayi Tyrosine-protein kinase abl-1 0.0026 0.0028 0.0028
Echinococcus multilocularis c src tyrosine kinase 0.0026 0.0028 0.0062
Echinococcus multilocularis protein kinase shaggy 0.0249 0.129 0.2802
Echinococcus granulosus dual specificity mitogen activated protein 0.0089 0.0383 0.1203
Loa Loa (eye worm) hypothetical protein 0.0045 0.0137 0.0137
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.006 0.0218 0.0473
Plasmodium falciparum transporter, putative 0.0032 0.006 0.0151
Brugia malayi hypothetical protein 0.0032 0.006 0.006
Echinococcus granulosus roundabout 2 0.0043 0.0123 0.0386
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0249 0.129 0.3577
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0081 0.0336 0.0731
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Giardia lamblia Kinase, CK1 Casein kinase 0.0052 0.0176 0.0475
Brugia malayi cell division control protein 2 homolog 0.0057 0.0205 0.0205
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Giardia lamblia Kinase, CMGC CLK 0.0136 0.0648 0.1789
Toxoplasma gondii cathepsin CPC1 0.0657 0.3596 1
Onchocerca volvulus 0.0026 0.0028 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0022 0.0006 0.0013
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0026 0.0028 0.0089
Echinococcus multilocularis 0.0122 0.0568 0.1233
Leishmania major protein kinase, putative 0.0136 0.0648 0.5
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0052 0.0176 0.0176
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0134 0.0638 0.1386
Echinococcus granulosus cyclin dependent kinase 7 0.0092 0.0399 0.1253
Trichomonas vaginalis STE family protein kinase 0.0089 0.0383 0.1731
Brugia malayi SRC-1 0.0026 0.0028 0.0028
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0052 0.0176 0.0176
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0022 0.0006 0.0006
Echinococcus multilocularis insulin receptor 0.0148 0.0717 0.1557
Loa Loa (eye worm) hypothetical protein 0.0043 0.0125 0.0125
Trichomonas vaginalis CMGC family protein kinase 0.0249 0.129 0.5892
Echinococcus granulosus cyclin dependent kinase 1 0.0057 0.0205 0.0644
Entamoeba histolytica protein kinase, putative 0.0177 0.0883 0.6829
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0024
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0026 0.0028 0.0062
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0657 0.3596 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0399 0.111
Echinococcus granulosus sodium and chloride dependent glycine 0.0163 0.0805 0.2524
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0032 0.006 0.006
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0177 0.0883 0.6829
Echinococcus multilocularis Immunoglobulin 0.0027 0.0034 0.0073
Echinococcus granulosus rho-associated protein kinase 1 0.0585 0.3188 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0444 0.239 0.239
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.006 0.0167
Loa Loa (eye worm) hypothetical protein 0.0163 0.0805 0.0805
Trypanosoma cruzi aurora B kinase, putative 0.0177 0.0883 0.6829
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0089 0.0249
Toxoplasma gondii AGC kinase 0.0095 0.0417 0.1138
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0382
Schistosoma mansoni protein kinase 0.006 0.0218 0.0606
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0417 0.1159
Loa Loa (eye worm) hypothetical protein 0.0095 0.0417 0.0417
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0648 0.1803
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0194 0.0978 0.7566
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0182 0.0912 0.198
Brugia malayi Stress-activated protein kinase jnk-1 0.0247 0.1278 0.1278
Giardia lamblia Encystation-specific protease 0.0249 0.129 0.3577
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0009 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0883 0.4024
Entamoeba histolytica protein kinase domain containing protein 0.0249 0.129 1
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Brugia malayi Protein kinase domain containing protein 0.0291 0.1527 0.1527
Echinococcus granulosus hypothetical protein 0.0122 0.0568 0.1781
Plasmodium vivax protein kinase Crk2 0.0057 0.0205 0.0555
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.003 0.005 0.005
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0249 0.129 1
Echinococcus multilocularis casein kinase I delta 0.0052 0.0176 0.0383
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.006 0.0218 0.0684
Echinococcus multilocularis tyrosine protein kinase Abl 0.0026 0.0028 0.0062
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0026 0.0157
Giardia lamblia Kinase, CAMK CAMKL 0.0045 0.0134 0.0358
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0095 0.0417 0.3199
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0026 0.0028 0.0079
Trypanosoma brucei SNF1-related protein kinases, putative 0.0037 0.0089 0.065
Loa Loa (eye worm) AUR protein kinase 0.0177 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0095 0.0417 0.1138
Echinococcus granulosus casein kinase i 0.0052 0.0176 0.0553
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.006 0.0167
Brugia malayi Immunoglobulin I-set domain containing protein 0.045 0.2424 0.2424
Leishmania major protein kinase, putative 0.0177 0.0883 0.6829
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0006 0.0016
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0501 0.2711 0.8504
Loa Loa (eye worm) TK protein kinase 0.0026 0.0028 0.0028
Brugia malayi Protein kinase domain containing protein 0.0148 0.0717 0.0717
Echinococcus granulosus cyclin dependent kinase 9 0.006 0.0218 0.0683
Loa Loa (eye worm) hypothetical protein 0.0163 0.0805 0.0805
Leishmania major casein kinase, putative 0.0052 0.0176 0.1327
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0148 0.0717 0.225
Brugia malayi Protein kinase domain containing protein 0.0073 0.0293 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.006 0.0167
Schistosoma mansoni protein kinase 0.0022 0.0006 0.0016
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0136 0.0648 0.5
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0036 0.0086 0.0086
Giardia lamblia Kinase, STE STE20 0.0089 0.0383 0.1052
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0009 0.0022
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0026 0.0028 0.0062
Echinococcus multilocularis death associated protein kinase 1 0.0836 0.4605 1
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0052 0.0176 0.1327
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0057 0.0205 0.0205
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0026 0.0028 0.0089
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0029 0.0044 0.0293
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.179 1 1
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0095 0.0417 0.1145
Loa Loa (eye worm) TK/ABL protein kinase 0.0026 0.0028 0.0028
Echinococcus multilocularis beta adrenergic receptor kinase 0.0027 0.0034 0.0074
Loa Loa (eye worm) hypothetical protein 0.0043 0.0123 0.0123
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0163 0.0805 0.0805
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0249 0.129 0.2802
Schistosoma mansoni protein kinase 0.0026 0.0026 0.0072
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0045 0.0137 0.0431
Trypanosoma brucei casein kinase I, isoform 2 0.0052 0.0176 0.1327
Echinococcus granulosus serine:threonine kinase SAD 1 0.0037 0.0089 0.0281
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0382
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0026 0.0157
Echinococcus granulosus tyrosine protein kinase Srms 0.0026 0.0028 0.0089
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0177 0.0883 0.6829
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Trypanosoma brucei protein kinase, putative 0.0249 0.129 1
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0073 0.0296 0.0927
Loa Loa (eye worm) AUR protein kinase 0.0177 0.0883 0.0883
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.006 0.0218 0.0473
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0978 0.7566
Schistosoma mansoni serine/threonine protein kinase 0.0585 0.3188 0.8865
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.0905
Echinococcus multilocularis casein kinase I alpha 0.0052 0.0176 0.0383
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0478 0.2581 0.2581
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0205 0.0571
Toxoplasma gondii hypothetical protein 0.0032 0.006 0.0143
Loa Loa (eye worm) serotonin transporter b 0.0032 0.006 0.006
Brugia malayi serine/threonine protein kinase 6 0.0177 0.0883 0.0883
Echinococcus multilocularis cyclin dependent kinase 7 0.0092 0.0399 0.0867
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0163 0.0805 0.0805
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0026 0.0028 0.0062
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0136 0.0648 0.5
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.0176 0.0782
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0708 0.1968
Brugia malayi Protein kinase domain containing protein 0.0136 0.0648 0.0648
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0417 0.1159
Schistosoma mansoni protein kinase 0.006 0.0218 0.0606
Leishmania major macrophage migration inhibitory factor-like protein 0.0036 0.0086 0.0627
Schistosoma mansoni tyrosine kinase 0.0027 0.0035 0.0097
Loa Loa (eye worm) gastrulation defective protein 1 0.0132 0.0627 0.0627
Onchocerca volvulus 0.0032 0.0059 0.0185
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0037 0.0089 0.065
Brugia malayi P21-Rho-binding domain containing protein 0.0045 0.0137 0.0137
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0057 0.0205 0.0644
Entamoeba histolytica protein kinase, putative 0.006 0.0218 0.1651
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.006 0.0218 0.0684
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Echinococcus multilocularis cyclin dependent kinase 9 0.0068 0.0263 0.0571
Echinococcus multilocularis PAK box P21 Rho binding 0.0045 0.0137 0.0299
Loa Loa (eye worm) AGC/PKA protein kinase 0.0095 0.0417 0.0417
Entamoeba histolytica serine/threonine protein kinase, putative 0.0037 0.0089 0.065
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0026 0.0028 0.0062
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0009 0.0013
Brugia malayi serine/threonine-protein kinase 6 0.0177 0.0883 0.0883
Onchocerca volvulus 0.0032 0.0059 0.0185
Schistosoma mansoni kinase 0.006 0.0218 0.0606
Echinococcus granulosus mitogen activated protein kinase 15 0.0022 0.0006 0.0018
Giardia lamblia Kinase, CMGC GSK 0.0249 0.129 0.3578
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0037 0.0089 0.065
Echinococcus multilocularis cyclin dependent kinase 0.0057 0.0205 0.0446
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Loa Loa (eye worm) SRC-1 0.0026 0.0028 0.0028
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0036 0.0086 0.0217
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0027 0.0034 0.0094
Echinococcus granulosus tyrosine protein kinase Src42A 0.0026 0.0028 0.0089
Onchocerca volvulus 0.0052 0.0176 0.0553
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.0176 0.0782
Brugia malayi Bm-MIF-1, identical 0.0036 0.0086 0.0086
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.0008
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0144 0.0693 0.0693
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.0143
Brugia malayi Furin-like cysteine rich region family protein 0.0444 0.239 0.239
Brugia malayi SH2 domain containing protein 0.0026 0.0028 0.0028
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0032 0.006 0.0189
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0027 0.0034 0.0094
Echinococcus granulosus tyrosine kinase 0.0026 0.0028 0.0089
Onchocerca volvulus 0.0026 0.0028 0.0089
Schistosoma mansoni sodium/chloride dependent transporter 0.0032 0.006 0.0167
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0026 0.0028 0.0089
Entamoeba histolytica protein kinase, putative 0.006 0.0218 0.1651
Plasmodium vivax casein kinase 1, putative 0.0052 0.0176 0.0475
Toxoplasma gondii casein kinase I 0.0052 0.0176 0.0467
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0026 0.0028 0.0062
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0136 0.0648 0.0648
Echinococcus multilocularis dual specificity mitogen activated protein 0.0089 0.0383 0.0832
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0501 0.2711 0.5887
Echinococcus multilocularis tyrosine kinase 0.0026 0.0028 0.0062
Trypanosoma cruzi cdc2-related kinase 1 0.0057 0.0205 0.1552
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0022 0.0006 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0122 0.0568 0.0568
Giardia lamblia Kinase, AGC PKA 0.0095 0.0417 0.1145
Echinococcus granulosus tyrosine protein kinase Src64B 0.0026 0.0028 0.0089
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.0008
Echinococcus granulosus c src tyrosine kinase 0.0026 0.0028 0.0089
Echinococcus multilocularis dual specificity protein kinase clk2 0.0136 0.0648 0.1408
Plasmodium falciparum protein kinase, putative 0.0026 0.0026 0.0056
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0045 0.0137 0.0299
Schistosoma mansoni protein kinase 0.0182 0.0912 0.2535
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0026 0.0028 0.0062
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0009 0.0022
Echinococcus granulosus casein kinase I alpha 0.0052 0.0176 0.0553
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Trypanosoma brucei cdc2-related kinase 3 0.0057 0.0205 0.1552
Loa Loa (eye worm) norepinephrine transporter 0.0032 0.006 0.006
Onchocerca volvulus 0.0032 0.006 0.0189
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0036 0.0086 0.037
Onchocerca volvulus 0.0032 0.006 0.0189
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.006 0.0167
Giardia lamblia Kinase, CAMK CAMKL 0.0045 0.0134 0.0358
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0026 0.0028 0.0089
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0028 0.0089
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0057 0.0205 0.0548
Loa Loa (eye worm) hypothetical protein 0.0037 0.0089 0.0089
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0026 0.0028 0.0175
Echinococcus multilocularis casein kinase I alpha 0.0052 0.0176 0.0383
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Entamoeba histolytica cell division protein kinase 2, putative 0.0057 0.0205 0.1552
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0081 0.0336 0.1055
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.0176 0.0782
Echinococcus granulosus tyrosine protein kinase shark 0.0026 0.0028 0.0089
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.0143
Giardia lamblia Kinase, CMGC CDK 0.0057 0.0205 0.0555
Plasmodium falciparum serine/threonine protein kinase, putative 0.0177 0.0883 0.2444
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.006 0.0167
Leishmania major protein kinase, putative 0.0136 0.0648 0.5
Echinococcus granulosus twitchin 0.0048 0.0153 0.0481
Echinococcus granulosus tyrosine kinase 0.0026 0.0028 0.0089
Echinococcus granulosus tyrosine protein kinase ABL1 0.0026 0.0028 0.0089
Schistosoma mansoni sodium-dependent amino acid transporter 0.0032 0.006 0.0167
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0131 0.062 0.1345
Plasmodium falciparum amino acid transporter, putative 0.0032 0.006 0.0151
Echinococcus multilocularis Immunoglobulin 0.0027 0.0034 0.0073
Brugia malayi Cytochrome P450 family protein 0.0032 0.0059 0.0059
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0249 0.129 0.3589
Echinococcus multilocularis dual specificity 0.0194 0.0978 0.2123
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0218 0.165
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0176 0.0491
Entamoeba histolytica protein kinase domain containing protein 0.0177 0.0883 0.6829
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0144 0.0693 0.0693
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0036 0.0086 0.0627
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0657 0.3596 1
Echinococcus granulosus neuroglian 0.0034 0.0073 0.0229
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0022 0.0006 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0883 0.4024
Toxoplasma gondii histone kinase SNF1, putative 0.0037 0.0089 0.0225
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Echinococcus granulosus cyclin dependent kinase 5 0.0057 0.0205 0.0644
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0182 0.0912 0.286
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0249 0.129 0.3577
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0478 0.2581 0.8095
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0009 0.0009
Echinococcus granulosus casein kinase I delta 0.0052 0.0176 0.0553
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0032 0.006 0.0131
Onchocerca volvulus 0.0026 0.0028 0.0089
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Echinococcus multilocularis PAK box P21 Rho binding 0.006 0.0218 0.0473
Echinococcus granulosus insulin receptor 0.0148 0.0717 0.225
Brugia malayi cyclin-dependent kinase 7 homolog 0.01 0.0444 0.0444
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0399 0.111

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.981071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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