Detailed information for compound 1274033

Basic information

Technical information
  • TDR Targets ID: 1274033
  • Name: 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N- (2-phenylethyl)triazole-4-carboxamide
  • MW: 418.263 | Formula: C18H17BrFN5O
  • H donors: 2 H acceptors: 3 LogP: 3.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(c(c1)F)Cn1nnc(c1N)C(=O)NCCc1ccccc1
  • InChi: 1S/C18H17BrFN5O/c19-14-7-6-13(15(20)10-14)11-25-17(21)16(23-24-25)18(26)22-9-8-12-4-2-1-3-5-12/h1-7,10H,8-9,11,21H2,(H,22,26)
  • InChiKey: XZXBWQMGGVLSDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-amino-1-[(4-bromo-2-fluoro-phenyl)methyl]-N-(2-phenylethyl)triazole-4-carboxamide
  • 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2-phenylethyl)-4-triazolecarboxamide
  • 5-amino-1-(4-bromo-2-fluoro-benzyl)-N-(2-phenylethyl)triazole-4-carboxamide
  • 5-amino-1-[(4-bromo-2-fluoro-phenyl)methyl]-N-(2-phenylethyl)-1,2,3-triazole-4-carboxamide
  • 5-amino-1-(4-bromo-2-fluorobenzyl)-N-(2-phenylethyl)-1H-1,2,3-triazole-4-carboxamide
  • MLS000731074
  • SMR000309449

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0035 0.0131 0.012
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0107 0.0672 0.0621
Giardia lamblia Prenyltransferase 0.0107 0.0672 0.4659
Echinococcus granulosus neuroligin 0.0035 0.0131 0.0181
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0133
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0054 0.0296
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0031 0.0105 0.0139
Loa Loa (eye worm) hexokinase 0.004 0.0173 0.0185
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0031 0.0105 0.0068
Echinococcus multilocularis chromobox protein 2 0.0024 0.0054 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0041
Mycobacterium ulcerans acetolactate synthase 0.0048 0.0227 0.0289
Onchocerca volvulus 0.0025 0.0061 0.004
Onchocerca volvulus 0.0024 0.0054 0.0034
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0131 0.017
Schistosoma mansoni CD36-like class B scavenger receptor 0.0057 0.0295 0.0484
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0051 0.0256 0.0327
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0035 0.0131 0.0743
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0013
Trypanosoma cruzi hexokinase, putative 0.004 0.0173 0.0208
Loa Loa (eye worm) helicase 0.0024 0.0054 0.0041
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0046 0.0213 0.1224
Echinococcus multilocularis carboxylesterase 5A 0.0205 0.1406 0.2278
Schistosoma mansoni disulfide oxidoreductase 0.0051 0.0256 0.042
Echinococcus granulosus carboxylesterase 5A 0.0205 0.1406 0.2278
Brugia malayi Carboxylesterase family protein 0.0205 0.1406 0.17
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0231 0.1599 0.2595
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0069
Brugia malayi hypothetical protein 0.0036 0.0141 0.017
Schistosoma mansoni rab6-interacting 0.002 0.0021 0.0034
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0035 0.0131 0.1094
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0107 0.0672 0.3905
Onchocerca volvulus 0.0035 0.0131 0.011
Leishmania major hypothetical protein, conserved 0.0051 0.0256 0.0513
Entamoeba histolytica hypothetical protein 0.0036 0.0141 0.1182
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0046 0.0213 0.1224
Brugia malayi Doublecortin family protein 0.002 0.0021 0.0025
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0051 0.0256 0.0387
Plasmodium vivax acyl-CoA synthetase, putative 0.0048 0.0227 0.1306
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0173 0.1167 0.1884
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0031 0.0105 0.0127
Schistosoma mansoni glutamate synthase 0.0051 0.0256 0.042
Onchocerca volvulus 0.005 0.0246 0.0226
Plasmodium vivax SET domain protein, putative 0.024 0.1669 0.9731
Plasmodium falciparum glutathione reductase 0.0247 0.1715 1
Echinococcus granulosus lamin 0.0027 0.0075 0.009
Echinococcus multilocularis acetylcholinesterase 0.0205 0.1406 0.2278
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0051 0.0256 0.1918
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0194 0.1321 0.2569
Loa Loa (eye worm) hypothetical protein 0.0286 0.2011 0.2412
Toxoplasma gondii selenide, water dikinase 0.0051 0.0256 0.1476
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0051 0.0256 0.2173
Schistosoma mansoni lipoxygenase 0.0119 0.0765 0.1253
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0031 0.0105 0.0068
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0131 0.0214
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0031 0.0105 0.0139
Treponema pallidum thioredoxin reductase (trxB) 0.0051 0.0256 0.1918
Schistosoma mansoni hypothetical protein 0.0052 0.0263 0.0431
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0141 0.0231
Echinococcus multilocularis hexokinase type 2 0.004 0.0173 0.0251
Loa Loa (eye worm) hypothetical protein 0.005 0.0246 0.0273
Loa Loa (eye worm) carboxylesterase 0.0205 0.1406 0.1679
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0051 0.0256 0.0387
Brugia malayi hypothetical protein 0.0024 0.0054 0.0065
Loa Loa (eye worm) hexokinase 0.0025 0.0061 0.0049
Trypanosoma brucei lanosterol synthase 0.0046 0.0213 0.0425
Echinococcus granulosus CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Loa Loa (eye worm) hypothetical protein 0.0038 0.0159 0.0168
Schistosoma mansoni BC026374 protein (S09 family) 0.0035 0.0131 0.0214
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0173 0.1167 0.1884
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0571 0.4139 0.8365
Echinococcus multilocularis tar DNA binding protein 0.0032 0.0111 0.0149
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0051 0.0256 0.0203
Plasmodium vivax thioredoxin reductase, putative 0.0247 0.1715 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0213 0.0233
Loa Loa (eye worm) programmed cell death 8 0.0051 0.0256 0.0285
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0051 0.0256 0.0203
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0051 0.0256 0.0327
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0051 0.0256 0.1476
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0021 0.01
Brugia malayi hypothetical protein 0.002 0.0021 0.0025
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0107 0.0672 0.0621
Brugia malayi hypoxia-induced factor 1 0.0053 0.027 0.0326
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0141 0.0198
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0051 0.0256 0.1241
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0051 0.0256 0.0513
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0111 0.0183
Schistosoma mansoni acetolactate synthase 0.0071 0.0403 0.0659
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0131 0.017
Schistosoma mansoni glutamate synthase 0.0051 0.0256 0.042
Leishmania major hexokinase, putative 0.004 0.0173 0.0344
Trypanosoma cruzi lanosterol synthase, putative 0.0046 0.0213 0.0289
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0051 0.0256 0.0203
Plasmodium falciparum thioredoxin reductase 0.0247 0.1715 1
Onchocerca volvulus 0.004 0.0173 0.0153
Onchocerca volvulus 0.0024 0.0054 0.0034
Brugia malayi Hexokinase family protein 0.004 0.0173 0.0209
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0133
Trichomonas vaginalis mercuric reductase, putative 0.0194 0.1321 0.1274
Loa Loa (eye worm) hypothetical protein 0.0082 0.0483 0.0561
Echinococcus multilocularis L aminoadipate semialdehyde 0.0063 0.0341 0.0527
Entamoeba histolytica hypothetical protein 0.0036 0.0141 0.1182
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0031 0.0105 0.0052
Echinococcus granulosus acetylcholinesterase 0.0205 0.1406 0.2278
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) 0.0036 0.0137 0.0179
Echinococcus multilocularis CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0054 0.0088
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0107 0.0672 0.5746
Onchocerca volvulus 0.0027 0.0075 0.0055
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0054 0.0435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0571 0.4139 0.8365
Loa Loa (eye worm) heterochromatin protein 1 0.0054 0.0275 0.0308
Mycobacterium tuberculosis Carboxylesterase LipT 0.0035 0.0131 0.017
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0343
Schistosoma mansoni intermediate filament proteins 0.0027 0.0075 0.0124
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0051 0.0256 0.0513
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0107 0.0672 0.3905
Echinococcus multilocularis Chromo domain 0.0024 0.0054 0.0055
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0194 0.1321 0.7699
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0173 0.1167 0.1911
Echinococcus granulosus glutamate synthase 0.0051 0.0256 0.0387
Echinococcus granulosus CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Echinococcus multilocularis CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Mycobacterium ulcerans monoxygenase 0.0051 0.0256 0.0327
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0051 0.0256 0.0338
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0194 0.1321 0.1705
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0333
Entamoeba histolytica hypothetical protein 0.0036 0.0141 0.1182
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.024 0.1669 0.271
Schistosoma mansoni hexokinase 0.004 0.0173 0.0284
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0121 0.0774 0.4501
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0131 0.017
Toxoplasma gondii thioredoxin reductase 0.0247 0.1715 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0051 0.0256 0.0203
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0127 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0256 0.0378
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0107 0.0672 0.107
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0035 0.0131 0.0158
Loa Loa (eye worm) thioredoxin reductase 0.0247 0.1715 0.2054
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0035 0.0131 0.0258
Schistosoma mansoni chromobox protein 0.0054 0.0275 0.045
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0035 0.0131 0.0214
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0057 0.0295 0.0484
Trypanosoma cruzi protein farnesyltransferase, putative 0.0107 0.0672 0.1233
Loa Loa (eye worm) MH2 domain-containing protein 0.0061 0.0324 0.0368
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.024 0.1669 0.9731
Echinococcus granulosus L aminoadipate semialdehyde 0.0063 0.0341 0.0527
Echinococcus granulosus lamin dm0 0.0027 0.0075 0.009
Trypanosoma cruzi hexokinase, putative 0.004 0.0173 0.0208
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0054 0.0296
Plasmodium vivax geranylgeranyltransferase, putative 0.0046 0.0213 0.1224
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0111 0.0183
Brugia malayi RNA binding protein 0.0032 0.0111 0.0135
Onchocerca volvulus 0.0031 0.0105 0.0085
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0194 0.1321 0.2138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0677 0.4934 1
Onchocerca volvulus 0.0066 0.0365 0.0346
Brugia malayi Carboxylesterase family protein 0.0035 0.0131 0.0158
Brugia malayi hypothetical protein 0.0021 0.0031 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0105 0.0068
Leishmania major trypanothione reductase 0.0247 0.1715 0.3472
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0063 0.0341 0.0412
Echinococcus multilocularis thioredoxin glutathione reductase 0.0247 0.1717 0.2788
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0051 0.0256 0.0387
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0054 0.0296
Giardia lamblia Rab geranylgeranyltransferase 0.0046 0.0213 0.0885
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0051 0.0256 0.0338
Echinococcus granulosus para nitrobenzyl esterase 0.0035 0.0131 0.0181
Trichomonas vaginalis set domain proteins, putative 0.1354 1 1
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0035 0.0131 0.0209
Onchocerca volvulus 0.0153 0.1017 0.0999
Echinococcus multilocularis neuroligin 0.0035 0.0131 0.0181
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0031 0.0105 0.0595
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0035 0.0131 0.0133
Brugia malayi Carboxylesterase family protein 0.0035 0.0131 0.0158
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0054 0.0296
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0051 0.0256 0.0338
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0048 0.0227 0.0289
Trypanosoma cruzi trypanothione reductase, putative 0.0247 0.1715 0.338
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0121 0.0774 0.0724
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0051 0.0256 0.0203
Toxoplasma gondii hypothetical protein 0.0031 0.0105 0.0595
Mycobacterium ulcerans carboxylesterase, LipT 0.0035 0.0131 0.0165
Brugia malayi Thiamine pyrophosphate enzyme, central domain containing protein 0.0083 0.0493 0.0596
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0025 0.0061 0.0067
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0032 0.0111 0.011
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0083 0.0493 0.0655
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0083 0.0493 0.0655
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0107 0.0672 0.3905
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0051 0.0256 0.0327
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0051 0.0256 0.0327
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0054 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.024 0.1669 0.2734
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0051 0.0256 0.0338
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0051 0.0256 0.0338
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.024 0.1669 0.2734
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0046 0.0213 0.0257
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0131 0.0214
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0194 0.1321 0.1764
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0159 0.0105
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0027 0.0072 0.0139
Echinococcus granulosus intermediate filament protein 0.0027 0.0075 0.009
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0088
Brugia malayi hypothetical protein 0.0021 0.0031 0.0038
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0063 0.0341 0.0559
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.024 0.1669 0.271
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0051 0.0256 0.0513
Giardia lamblia Glutamate synthase 0.0051 0.0256 0.1241
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0051 0.0256 0.0378
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0194 0.1321 0.2673
Echinococcus granulosus chromobox protein 1 0.0054 0.0275 0.0418
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0051 0.0256 0.0378
Schistosoma mansoni acetylcholinesterase 0.0035 0.0131 0.0214
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0083 0.0493 0.0633
Schistosoma mansoni polycystin 1-related 0.002 0.0021 0.0034
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0051 0.0256 0.1476
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0051 0.0256 0.0327
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0035 0.0131 0.0181
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0051 0.0256 0.031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0501 0.0789
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0133
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0035 0.0131 0.0077
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0194 0.1321 0.7699
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0054 0.0065
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0051 0.0256 0.0327
Mycobacterium ulcerans NADH dehydrogenase 0.0051 0.0256 0.0327
Echinococcus multilocularis lamin 0.0027 0.0075 0.009
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0075 0.0067
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0035 0.0131 0.0181
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0041
Echinococcus multilocularis jun protein 0.0084 0.0501 0.0789
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0046 0.0213 0.0316
Echinococcus granulosus Chromo domain 0.0024 0.0054 0.0055
Brugia malayi TAR-binding protein 0.0032 0.0111 0.0135
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0194 0.1321 0.2569
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0051 0.0256 0.0378
Echinococcus multilocularis CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0131 0.0214
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0035 0.0131 0.017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0041
Schistosoma mansoni acetolactate synthase 0.0071 0.0403 0.0659
Onchocerca volvulus 0.004 0.0173 0.0153
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0075 0.0091
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.017 0.015
Echinococcus granulosus microtubule associated protein 2 0.0833 0.6104 1
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0083 0.0493 0.0633
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0677 0.4934 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0194 0.1321 0.1764
Trypanosoma cruzi trypanothione reductase, putative 0.0194 0.1321 0.2569
Brugia malayi Pre-SET motif family protein 0.1123 0.8272 1
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0121 0.0774 0.4501
Echinococcus granulosus hexokinase 0.004 0.0173 0.0251
Loa Loa (eye worm) hexokinase 0.004 0.0173 0.0185
Brugia malayi hypothetical protein 0.0058 0.0303 0.0367
Echinococcus multilocularis lysosome membrane protein 2 0.0057 0.0295 0.0452
Schistosoma mansoni gliotactin 0.0035 0.0131 0.0214
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0194 0.1321 0.7699
Brugia malayi Carboxylesterase family protein 0.0035 0.0131 0.0158
Plasmodium falciparum glutathione reductase 0.0194 0.1321 0.7699
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0765 0.1223
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0107 0.0672 0.0621
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0051 0.0256 0.0327
Schistosoma mansoni chromobox protein 0.0024 0.0054 0.0088
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0107 0.0672 0.0621
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0173 0.1167 0.1389
Toxoplasma gondii hypothetical protein 0.0089 0.054 0.3134
Brugia malayi follicle stimulating hormone receptor 0.0235 0.1626 0.1965
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0051 0.0256 0.0387
Loa Loa (eye worm) TAR-binding protein 0.0032 0.0111 0.011
Leishmania major acetoin dehydrogenase e3 component-like protein 0.05 0.3607 0.731
Brugia malayi bZIP transcription factor family protein 0.0084 0.0501 0.0605
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0054 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0159 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0256 0.0513
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0013
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0051 0.0256 0.0338
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0121 0.0774 0.1238
Trypanosoma cruzi lanosterol synthase, putative 0.0046 0.0213 0.0289
Loa Loa (eye worm) hypoxia-induced factor 1 0.0053 0.027 0.0302
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1123 0.8272 1
Echinococcus granulosus Chromobox protein 3 0.0024 0.0054 0.0055
Loa Loa (eye worm) transcription factor SMAD2 0.0061 0.0324 0.0368
Brugia malayi hypothetical protein 0.0066 0.0365 0.0442
Trypanosoma cruzi NADH dehydrogenase, putative 0.0051 0.0256 0.0378
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0121 0.0774 0.0724
Entamoeba histolytica hexokinase 2 0.004 0.0173 0.146
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0035 0.0131 0.012
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0031 0.0105 0.0207
Echinococcus granulosus histone lysine methyltransferase setb 0.024 0.1669 0.271
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0173 0.1167 0.141
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0051 0.0256 0.0203
Schistosoma mansoni glutamate synthase 0.0051 0.0256 0.042
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0057 0.0295 0.0275
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0677 0.4934 1
Echinococcus granulosus jun protein 0.0084 0.0501 0.0789
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0051 0.0256 0.0338
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0051 0.0256 0.1476
Schistosoma mansoni neuroligin 3 (S09 family) 0.0035 0.0131 0.0214
Leishmania major NADH dehydrogenase, putative 0.0051 0.0256 0.0513
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0046 0.0213 0.0349
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0173 0.1167 1
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0046 0.0213 0.1801
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0083 0.0493 0.0633
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0031 0.0105 0.0595
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0571 0.4139 0.8388
Schistosoma mansoni sulfide quinone reductase 0.0051 0.0256 0.042
Entamoeba histolytica hypothetical protein 0.0024 0.0054 0.0435
Schistosoma mansoni lipoxygenase 0.0084 0.0496 0.0812
Leishmania major hypothetical protein, conserved 0.0051 0.0256 0.0513
Entamoeba histolytica disulphide oxidoreductase, putative 0.0051 0.0256 0.2173
Mycobacterium ulcerans hypothetical protein 0.0083 0.0493 0.0633
Brugia malayi SET domain containing protein 0.0295 0.2081 0.2515
Schistosoma mansoni hypothetical protein 0.0036 0.0141 0.0231
Plasmodium vivax glutathione reductase, putative 0.0247 0.1715 1
Trichomonas vaginalis glutathione reductase, putative 0.0194 0.1321 0.1274
Schistosoma mansoni jun-related protein 0.0068 0.0383 0.0627
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0213 0.0289
Brugia malayi CD36 family protein 0.0057 0.0295 0.0357
Entamoeba histolytica hypothetical protein 0.0024 0.0054 0.0435
Schistosoma mansoni hypothetical protein 0.0068 0.0383 0.0627
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0051 0.0256 0.0203
Plasmodium vivax ferrodoxin reductase, putative 0.0051 0.0256 0.1476
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.1626 0.1945
Schistosoma mansoni chromobox protein 0.0054 0.0275 0.045
Trichomonas vaginalis spcc417.12 protein, putative 0.0035 0.0131 0.0077
Onchocerca volvulus Hexokinase homolog 0.0025 0.0061 0.004
Loa Loa (eye worm) hypothetical protein 0.024 0.1669 0.1998
Loa Loa (eye worm) glutathione reductase 0.0247 0.1715 0.2054
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0054 0.0088
Leishmania major phosphonopyruvate decarboxylase-like protein 0.0027 0.0072 0.0139
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0051 0.0256 0.1476
Brugia malayi hexokinase 0.004 0.0173 0.0209
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0051 0.0256 0.0327
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.024 0.1669 0.2734
Brugia malayi Carboxylesterase family protein 0.0205 0.1406 0.17
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0051 0.0256 0.2173
Loa Loa (eye worm) carboxylesterase 0.0035 0.0131 0.0133
Brugia malayi hypothetical protein 0.002 0.0021 0.0025
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0194 0.1321 0.2165
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0107 0.0672 0.107
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0035 0.0131 0.0165
Treponema pallidum NADH oxidase 0.0194 0.1321 1
Echinococcus multilocularis chromobox protein 1 0.0054 0.0275 0.0418
Echinococcus granulosus geminin 0.0341 0.2425 0.3952
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0141 0.0198
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0031 0.0105 0.0139
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0051 0.0256 0.0387
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0041
Echinococcus granulosus tumor protein p63 0.0342 0.2431 0.3962
Treponema pallidum hexokinase (hxk) 0.004 0.0173 0.1289
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0765 0.1223
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0041
Onchocerca volvulus 0.0027 0.0075 0.0055
Echinococcus multilocularis hexokinase 0.004 0.0173 0.0251
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.1051 0.7733 1
Onchocerca volvulus 0.0526 0.3809 0.3796
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1016 0.7474 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0121 0.0774 0.0724
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0121 0.0774 0.1238
Loa Loa (eye worm) RNA binding protein 0.0032 0.0111 0.011
Echinococcus multilocularis chromobox protein 1 0.0054 0.0275 0.0418
Onchocerca volvulus 0.004 0.0173 0.0153
Schistosoma mansoni rab6-interacting 0.002 0.0021 0.0034
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0051 0.0256 0.0203
Entamoeba histolytica hexokinase 1 0.004 0.0173 0.146
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0051 0.0256 0.031
Brugia malayi CHD4 protein 0.0024 0.0054 0.0065
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0121 0.0774 0.1268
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0121 0.0774 0.0913
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0107 0.0672 0.0621
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0246 0.0403
Schistosoma mansoni chromobox protein 0.0024 0.0054 0.0088
Onchocerca volvulus 0.0051 0.0256 0.0236
Loa Loa (eye worm) hypothetical protein 0.0121 0.0774 0.0913
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0013
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0051 0.0256 0.0327
Onchocerca volvulus 0.0035 0.0131 0.011
Brugia malayi hypothetical protein 0.0035 0.0131 0.0158
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0194 0.1321 0.1705
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0035 0.0131 0.0181
Echinococcus granulosus chromobox protein 1 0.0054 0.0275 0.0418
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0051 0.0256 0.0327
Schistosoma mansoni sulfide quinone reductase 0.0051 0.0256 0.042
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0051 0.0256 0.0285
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0111 0.0183
Plasmodium falciparum thioredoxin reductase 0.0194 0.1321 0.7699
Schistosoma mansoni hypothetical protein 0.002 0.0021 0.0034
Echinococcus granulosus CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0194 0.1321 1
Trichomonas vaginalis chromobox protein, putative 0.0054 0.0275 0.0222
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0571 0.4139 0.8388
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0035 0.0131 0.0165
Entamoeba histolytica hypothetical protein 0.0036 0.0141 0.1182
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0051 0.0256 0.1476
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0054 0.0065
Echinococcus multilocularis CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0054 0.0055
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0031 0.0105 0.0207
Leishmania major geranylgeranyltransferase, putative 0.0046 0.0213 0.0425
Echinococcus granulosus lysosome membrane protein 2 0.0057 0.0295 0.0452
Leishmania major hypothetical protein, conserved 0.0051 0.0256 0.0513
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0054 0.0296
Entamoeba histolytica thioredoxin reductase, putative 0.0051 0.0256 0.2173
Echinococcus granulosus hexokinase type 2 0.004 0.0173 0.0251
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0107 0.0672 0.0621
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0035 0.0131 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0213 0.0289
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0054 0.0065
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0035 0.0131 0.0258
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0107 0.0672 0.1356
Brugia malayi Heterochromatin protein 1 0.0054 0.0275 0.0332
Trichomonas vaginalis apoptosis inducing factor, putative 0.0051 0.0256 0.0203
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0333
Trypanosoma brucei NADH dehydrogenase 0.0051 0.0256 0.0513
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0035 0.0131 0.0743
Plasmodium falciparum hexokinase 0.004 0.0173 0.0992
Onchocerca volvulus 0.0035 0.0131 0.011
Mycobacterium tuberculosis Probable reductase 0.0051 0.0256 0.0338
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0245 0.0272
Mycobacterium tuberculosis Probable dehydrogenase 0.0051 0.0256 0.0338
Giardia lamblia NADH oxidase lateral transfer candidate 0.0194 0.1321 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0142 0.0936 0.1132
Trypanosoma brucei hexokinase, putative 0.004 0.0173 0.0344
Echinococcus multilocularis geminin 0.0341 0.2425 0.3952
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.05 0.3607 0.7271
Schistosoma mansoni SET domain protein 0.0025 0.0061 0.0101
Echinococcus granulosus CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0046 0.0213 0.0425
Plasmodium falciparum ferrodoxin reductase-like protein 0.0051 0.0256 0.1476
Loa Loa (eye worm) hexokinase type II 0.004 0.0173 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0111 0.0183
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0205 0.1406 0.2304
Giardia lamblia Thioredoxin reductase 0.0051 0.0256 0.1241
Mycobacterium ulcerans dehydrogenase 0.0051 0.0256 0.0327
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0048 0.0227 0.0454
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0054 0.0088
Echinococcus granulosus chromobox protein 2 0.0024 0.0054 0.0055
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0194 0.1321 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0142 0.0936 0.1132
Plasmodium vivax hexokinase, putative 0.004 0.0173 0.0992
Loa Loa (eye worm) hypothetical protein 0.0034 0.0127 0.0129
Brugia malayi Carboxylesterase family protein 0.0035 0.0131 0.0158
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0051 0.0256 0.0338
Mycobacterium tuberculosis Probable oxidoreductase 0.0194 0.1321 0.1764
Loa Loa (eye worm) hypothetical protein 0.0153 0.1017 0.1208
Trichomonas vaginalis chromobox protein, putative 0.004 0.017 0.0117
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0194 0.1321 0.1705
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0051 0.0256 0.0387
Loa Loa (eye worm) hypothetical protein 0.0051 0.0256 0.0285
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.05 0.3607 0.7271
Schistosoma mansoni tar DNA-binding protein 0.0032 0.0111 0.0183
Plasmodium falciparum geranylgeranyltransferase, putative 0.0046 0.0213 0.1224
Trypanosoma brucei trypanothione reductase 0.0247 0.1715 0.3472
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0051 0.0256 0.1476
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1051 0.7733 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0035 0.0131 0.0181
Schistosoma mansoni loxhd1 0.002 0.0021 0.0034
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0046 0.0213 0.1224
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0054 0.0296
Echinococcus multilocularis tumor protein p63 0.0342 0.2431 0.3962
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0173 0.1167 0.1911
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0107 0.0672 0.0812
Trypanosoma cruzi NADH dehydrogenase, putative 0.0051 0.0256 0.0378
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0051 0.0256 0.0513
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0046 0.0213 0.1224
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0035 0.0131 0.0181
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0133
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0031 0.0105 0.0139
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0075 0.0067
Brugia malayi Thioredoxin reductase 0.0247 0.1715 0.2073
Schistosoma mansoni lamin 0.0027 0.0075 0.0124
Trichomonas vaginalis glutamate synthase, putative 0.0051 0.0256 0.0203
Echinococcus granulosus hexokinase 0.004 0.0173 0.0251
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0051 0.0256 0.1918
Leishmania major farnesyltransferase beta subunit 0.0107 0.0672 0.1356
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0159 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0133
Loa Loa (eye worm) hypothetical protein 0.0271 0.1898 0.2275
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0054 0.0088
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.6104 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0205 0.1406 0.1679
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0051 0.0256 0.0513
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0051 0.0256 0.0338
Echinococcus granulosus BC026374 protein S09 family 0.0035 0.0131 0.0181
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0194 0.1321 0.2673
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0051 0.0256 0.0387
Echinococcus granulosus acetylcholinesterase 0.0205 0.1406 0.2278
Mycobacterium ulcerans ferredoxin reductase 0.0051 0.0256 0.0327
Mycobacterium ulcerans hypothetical protein 0.0027 0.0072 0.0089
Brugia malayi RNA recognition motif domain containing protein 0.0032 0.0111 0.0135
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0247 0.1715 0.2292
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0051 0.0256 0.1918
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0194 0.1321 0.1705
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0054 0.0435
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0031 0.0105 0.0068
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0121 0.0774 0.0936
Echinococcus multilocularis glutamate synthase 0.0051 0.0256 0.0387
Echinococcus multilocularis acetylcholinesterase 0.0205 0.1406 0.2278
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0051 0.0256 0.0203
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0031 0.0105 0.0103
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0051 0.0256 0.0378
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0054 0.0055
Plasmodium falciparum acyl-CoA synthetase 0.0048 0.0227 0.1306
Schistosoma mansoni hypothetical protein 0.0341 0.2425 0.3972
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0051 0.0256 0.2173
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0051 0.0256 0.0387
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0051 0.0256 0.0387
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0061 0.033 0.1909
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0051 0.0256 0.0387
Onchocerca volvulus 0.0035 0.0131 0.011
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0051 0.0256 0.0387
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0194 0.1321 0.1764
Echinococcus multilocularis hexokinase 0.004 0.0173 0.0251
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0194 0.1321 0.2138
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0051 0.0256 0.031
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0054 0.0435
Entamoeba histolytica hypothetical protein 0.0024 0.0054 0.0435
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0089 0.054 0.0489
Trypanosoma brucei hexokinase 0.004 0.0173 0.0344
Loa Loa (eye worm) hypothetical protein 0.005 0.0245 0.0272
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0051 0.0256 0.0338
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0121 0.0774 0.6624
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0046 0.0213 0.016
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0051 0.0256 0.0378
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0054 0.0296
Trichomonas vaginalis chromobox protein, putative 0.0054 0.0275 0.0222
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0046 0.0213 0.016
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0035 0.0131 0.1094
Brugia malayi Hexokinase family protein 0.0025 0.0061 0.0073
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0051 0.0256 0.1476
Brugia malayi Pre-SET motif family protein 0.024 0.1669 0.2018
Brugia malayi Protein cec-1. 0.0024 0.0054 0.0065
Loa Loa (eye worm) ILVBL protein 0.005 0.0248 0.0275
Brugia malayi glutamate synthase 0.0051 0.0256 0.031
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0526 0.3809 0.624
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0256 0.0378
Echinococcus granulosus thioredoxin glutathione reductase 0.0247 0.1717 0.2788
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0046 0.0213 0.028
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0245 0.0296
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0051 0.0256 0.0513
Loa Loa (eye worm) hypothetical protein 0.0046 0.0213 0.0233
Toxoplasma gondii NADPH-glutathione reductase 0.0194 0.1321 0.7699
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0105 0.0068
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0035 0.0131 0.0743
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0051 0.0256 0.0203
Treponema pallidum oxidoreductase 0.0051 0.0256 0.1918
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0054 0.0055
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0051 0.0256 0.2173
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0107 0.0672 0.0789
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0173 0.1167 0.1119
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0051 0.0256 0.0327
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0027 0.0072 0.0139
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0501 0.0789
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0194 0.1321 0.7699
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0194 0.1321 0.7699
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0025 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0062
Trypanosoma brucei hexokinase 0.004 0.0173 0.0344
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0031 0.0105 0.0207
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.6104 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.0107 0.0672 0.1233
Mycobacterium ulcerans glutamate synthase subunit beta 0.0051 0.0256 0.0327
Echinococcus multilocularis musashi 0.0027 0.0075 0.009
Mycobacterium ulcerans hypothetical protein 0.0051 0.0256 0.0327
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0021 0.01
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0054 0.0055
Echinococcus granulosus hexokinase 0.004 0.0173 0.0251
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0031 0.0105 0.0876
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0051 0.0256 0.0387
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0083 0.0493 0.0633
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0105 0.0207
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0051 0.0256 0.1476
Brugia malayi intermediate filament protein 0.0027 0.0075 0.0091
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0051 0.0256 0.2173
Schistosoma mansoni hypothetical protein 0.0034 0.0127 0.0207
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0245 0.0296
Onchocerca volvulus 0.0035 0.0131 0.011
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0054 0.0296
Schistosoma mansoni hypothetical protein 0.0341 0.2425 0.3972
Echinococcus granulosus CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Giardia lamblia Rab geranylgeranyltransferase 0.0121 0.0774 0.5499
Leishmania major hexokinase, putative 0.004 0.0173 0.0344
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0048 0.0227 0.0289
Chlamydia trachomatis thioredoxin reductase 0.0051 0.0256 0.1918
Schistosoma mansoni CD36-like class B scavenger receptor 0.0057 0.0295 0.0484
Trichomonas vaginalis glutamate synthase, putative 0.0051 0.0256 0.0203
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0031 0.0105 0.0207
Toxoplasma gondii hexokinase 0.004 0.0173 0.0992
Brugia malayi MH2 domain containing protein 0.0061 0.0324 0.0392
Loa Loa (eye worm) hypothetical protein 0.0063 0.0341 0.0389
Loa Loa (eye worm) hypothetical protein 0.0205 0.1406 0.1679
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0051 0.0256 0.1476
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0048 0.0228 0.0251
Echinococcus granulosus tar DNA binding protein 0.0032 0.0111 0.0149
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0031 0.0105 0.0172
Onchocerca volvulus 0.0063 0.0341 0.0321
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0046 0.0213 0.0289
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0194 0.1321 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0333
Echinococcus multilocularis lamin dm0 0.0027 0.0075 0.009
Schistosoma mansoni lamin 0.0027 0.0075 0.0124
Trichomonas vaginalis chromobox protein, putative 0.004 0.017 0.0117
Schistosoma mansoni cd36 antigen 0.0021 0.0031 0.0052
Echinococcus multilocularis BC026374 protein (S09 family) 0.0035 0.0131 0.0181
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0051 0.0256 0.0327
Loa Loa (eye worm) hypothetical protein 0.0205 0.1406 0.1679
Brugia malayi hypothetical protein 0.0153 0.1017 0.123
Schistosoma mansoni hypothetical protein 0.0051 0.0256 0.042
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0054 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0054 0.0296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0677 0.4934 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.0057 0.0295 0.0452
Loa Loa (eye worm) hypothetical protein 0.0027 0.0075 0.0067
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0194 0.1321 0.1597
Brugia malayi glutathione reductase 0.0247 0.1715 0.2073
Echinococcus multilocularis hexokinase 0.004 0.0173 0.0251
Loa Loa (eye worm) carboxylesterase 0.0035 0.0131 0.0133
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.05 0.3607 0.731
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0107 0.0672 0.1101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0041
Brugia malayi chromobox protein homolog 3 0.0038 0.0159 0.0192

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1158 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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