Detailed information for compound 1305278

Basic information

Technical information
  • TDR Targets ID: 1305278
  • Name: ethyl 1,5-diethyl-3-furan-2-yl-4,6-dioxo-2,3, 3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1-carbo xylate
  • MW: 334.367 | Formula: C17H22N2O5
  • H donors: 1 H acceptors: 3 LogP: 0.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1(CC)NC(C2C1C(=O)N(C2=O)CC)c1ccco1
  • InChi: 1S/C17H22N2O5/c1-4-17(16(22)23-6-3)12-11(14(20)19(5-2)15(12)21)13(18-17)10-8-7-9-24-10/h7-9,11-13,18H,4-6H2,1-3H3
  • InChiKey: WHQLYJSNDOIVHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 1,5-diethyl-3-(2-furyl)-4,6-dioxo-2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1-carboxylate
  • 1,5-diethyl-3-(2-furyl)-4,6-dioxo-2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester
  • 1,5-diethyl-3-(2-furyl)-4,6-diketo-2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester
  • 1,5-Diethyl-3-furan-2-yl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic
  • ASN 06210151
  • 1,5-Diethyl-3-furan-2-yl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester
  • MLS000122446
  • SMR000119868

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Onchocerca volvulus 0.0019 0.0033 0.0371
Onchocerca volvulus 0.0027 0.0082 0.0911
Brugia malayi MH1 domain containing protein 0.0017 0.0019 0.0068
Schistosoma mansoni DNA polymerase eta 0.0023 0.0057 0.0059
Loa Loa (eye worm) DR-78 0.0019 0.0033 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0546
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0033 0.0371
Entamoeba histolytica hypothetical protein 0.011 0.0594 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.021 0.0679
Trypanosoma brucei trypanothione reductase 0.005 0.022 0.9674
Brugia malayi nuclear hormone receptor 0.0041 0.0168 0.0589
Echinococcus granulosus mucolipin 3 0.0076 0.0385 0.0395
Onchocerca volvulus 0.0048 0.021 0.2339
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0019 0.085
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0174 0.0609
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1132 0.1164
Brugia malayi nuclear hormone receptor 0.0019 0.0033 0.0116
Echinococcus multilocularis protein dispatched 1 0.0048 0.0211 0.0211
Plasmodium falciparum glutathione reductase 0.005 0.022 0.6044
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0183 0.0594
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.002
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0033 0.0034
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0057 0.0185
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0033 0.0371
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0168 0.0173
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0012 0.0323
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0019 0.085
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1132 0.3966
Schistosoma mansoni smad 0.0017 0.0019 0.002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0082 0.0286
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0183 0.0594
Schistosoma mansoni Smad4 0.0017 0.0019 0.002
Brugia malayi Smad1 0.0017 0.0019 0.0068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0168 0.0168
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0168 0.0168
Echinococcus granulosus intermediate filament protein 0.0027 0.0082 0.0084
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0155 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0255 0.0262
Plasmodium falciparum glutathione reductase 0.0017 0.0019 0.0531
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0073 0.0364 0.1276
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0168 0.0173
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0012 0.0516
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0019
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0033 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0692 0.2241
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0048 0.0048
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0228 0.0737
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0168 0.0173
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0014 0.0597
Schistosoma mansoni hypothetical protein 0.1584 0.9727 1
Brugia malayi hypothetical protein 0.0022 0.0048 0.0167
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0168 0.0589
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.021 0.9214
Brugia malayi nuclear receptor NHR-88 0.0019 0.0033 0.0116
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0033 0.0034
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0183 0.0642
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0014 0.0597
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0057 0.0185
Plasmodium falciparum thioredoxin reductase 0.005 0.022 0.6044
Brugia malayi MAP kinase sur-1 0.0051 0.0228 0.0797
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0073 0.0364 1
Echinococcus multilocularis expressed protein 0.0039 0.0155 0.0155
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0057 0.0185
Echinococcus multilocularis lamin dm0 0.0027 0.0082 0.0082
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.002
Brugia malayi glutaminase DH11.1 0.0287 0.169 0.592
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0168 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0255 0.0262
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0073 0.0364 0.118
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0057 0.0185
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0057 0.0057
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0614 0.1988
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0057 0.0059
Mycobacterium ulcerans L-lysine aminotransferase 0.0073 0.0364 0.118
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0228 0.0234
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0168 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0048 0.0167
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0057 0.0963
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.021 0.3529
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0183 0.5033
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.0735
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0019 0.0531
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0057 0.2515
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0149 0.6537
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0228 0.0234
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.021 0.0679
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0048 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0048 0.021 0.0735
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.0323
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0168 0.0589
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.0534 0.0549
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0534 0.0549
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0228 0.0737
Plasmodium falciparum thioredoxin reductase 0.0017 0.0019 0.0531
Brugia malayi latrophilin 2 splice variant baaae 0.0217 0.1256 0.4399
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0614 0.1988
Onchocerca volvulus 0.0041 0.0168 0.1874
Onchocerca volvulus Huntingtin homolog 0.0123 0.0677 0.7549
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0014 0.0044
Brugia malayi Coelomocyte uptake defective protein 5 0.0076 0.0385 0.1348
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.021 0.0679
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0048 0.021 0.0735
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0033 0.0033
Trypanosoma brucei unspecified product 0.0016 0.0012 0.0546
Schistosoma mansoni nuclear receptor 0.0019 0.0033 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0168 0.0589
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0228 1
Brugia malayi nuclear receptor RXR 0.0019 0.0033 0.0116
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0135 0.3343
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0168 0.0173
Schistosoma mansoni hypothetical protein 0.01 0.0534 0.0549
Brugia malayi hypothetical protein 0.0159 0.0897 0.3141
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0168 0.0173
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1132 0.1132
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0168 0.0173
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0149 0.6537
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.2854 0.2935
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0019 0.0068
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0255 0.0894
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0692 0.2241
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0057 0.0059
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0168 0.0168
Brugia malayi hypothetical protein 0.0123 0.0677 0.2371
Echinococcus multilocularis lamin 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0168 0.0168
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0513 0.3089 1
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0033 0.0116
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0149 0.4084
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0033 0.0116
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0228 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0014 0.0152
Loa Loa (eye worm) Smad1 0.0017 0.0019 0.0068
Brugia malayi hypothetical protein 0.0475 0.2854 1
Schistosoma mansoni mucolipin 0.007 0.0345 0.0355
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.021 0.0679
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0048 0.0167
Schistosoma mansoni nuclear receptor 0.0019 0.0033 0.0034
Plasmodium vivax glutathione reductase, putative 0.005 0.022 0.6044
Echinococcus multilocularis Aminotransferase class III 0.0073 0.0364 0.0364
Schistosoma mansoni rotamase 0.0039 0.0155 0.0159
Echinococcus granulosus Smad4 0.0017 0.0019 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.022 0.0713
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0168 0.0589
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Echinococcus multilocularis musashi 0.0027 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0082 0.0286
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0019 0.002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0516
Schistosoma mansoni hypothetical protein 0.01 0.0534 0.0549
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0534 0.1872
Loa Loa (eye worm) glutaminase 0.0287 0.169 0.592
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0012 0.0012
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0513 0.3089 1
Schistosoma mansoni coup transcription factor 0.0041 0.0168 0.0173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0217 0.1256 0.4399
Brugia malayi intermediate filament protein 0.0027 0.0082 0.0286
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Schistosoma mansoni microtubule-associated protein tau 0.0759 0.4613 0.4743
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0019 0.0063
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0019 0.0531
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0033 0.0034
Schistosoma mansoni alpha-glucosidase 0.0169 0.0962 0.0989
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0033 0.0034
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0019 0.085
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0135 0.3696
Schistosoma mansoni lamin 0.0027 0.0082 0.0084
Brugia malayi Calcitonin receptor-like protein seb-1 0.0317 0.1877 0.6577
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Brugia malayi glutathione reductase 0.005 0.022 0.0771
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0073 0.0364 0.118
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0019 0.0531
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0019 0.085
Mycobacterium ulcerans hypothetical protein 0.0513 0.3089 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0019 0.0063
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0003 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0534 0.1872
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0228 0.6247
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0168 0.0589
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0019 0.002
Mycobacterium ulcerans glutaminase 0.0287 0.169 0.5471
Onchocerca volvulus Huntingtin homolog 0.0123 0.0677 0.7549
Echinococcus multilocularis smad 0.0017 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0286
Mycobacterium tuberculosis Probable reductase 0.0113 0.0614 0.1988
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0201
Onchocerca volvulus 0.0027 0.0082 0.0911
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0019 0.0531
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0275
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.1477 0.5176
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0692 0.2241
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Echinococcus granulosus dna polymerase kappa 0.0023 0.0057 0.0059
Schistosoma mansoni hypothetical protein 0.01 0.0534 0.0549
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0033 0.0033
Echinococcus multilocularis microtubule associated protein 2 0.0759 0.4613 0.4613
Brugia malayi AMP-binding enzyme family protein 0.0048 0.021 0.0735
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.021 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0168 0.0589
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.021 0.0679
Echinococcus granulosus Aminotransferase class III 0.0073 0.0364 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0546
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0228 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0183 0.8056
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0019 0.0063
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.01 0.0534 0.1872
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0174 0.0563
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0168 0.0589
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0149 0.6537
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.021 0.3529
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0614 0.1988
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0174 0.0174
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0033 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Trichomonas vaginalis rotamase, putative 0.0038 0.0149 0.0482
Echinococcus granulosus GPCR family 2 0.01 0.0534 0.0549
Mycobacterium tuberculosis Probable aminotransferase 0.0513 0.3089 1
Onchocerca volvulus 0.0114 0.0618 0.6892
Plasmodium vivax ornithine aminotransferase, putative 0.0073 0.0364 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0048
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0317 0.1877 0.6577
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0168 0.0589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.021 0.0679
Giardia lamblia DINP protein human, muc B family 0.0023 0.0057 0.182
Schistosoma mansoni alpha-glucosidase 0.0169 0.0962 0.0989
Entamoeba histolytica hypothetical protein 0.011 0.0594 1
Brugia malayi nuclear receptor NHR-67 0.0019 0.0033 0.0116
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0057 0.0185
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0135 0.0436
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0019 0.085
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0155 0.05
Schistosoma mansoni survival motor neuron protein 0.0097 0.0513 0.0527
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0073 0.0364 1
Schistosoma mansoni zinc finger protein 0.0019 0.0033 0.0034
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0014 0.0044
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0168 0.0589
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Onchocerca volvulus 0.0097 0.0513 0.572
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0513 0.3089 1
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0183 0.8056
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0183 0.0594
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0057 0.2515
Echinococcus granulosus dna polymerase eta 0.0023 0.0057 0.0059
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0169
Brugia malayi MH2 domain containing protein 0.0252 0.1477 0.5176
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0594 0.0611
Loa Loa (eye worm) glutaminase 2 0.0287 0.169 0.592
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0033 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0019 0.085
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0183 0.0642
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.2854 0.2854
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0033 0.0033
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0183 0.0189
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0183 0.3086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Brugia malayi hypothetical protein 0.011 0.0594 0.2082
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0135 0.0436
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Schistosoma mansoni hypothetical protein 0.1584 0.9727 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0057 0.2515
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0073 0.0364 0.118
Loa Loa (eye worm) hypothetical protein 0.0123 0.0677 0.2371
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0174 0.0179
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.022 0.022
Echinococcus granulosus geminin 0.1584 0.9727 1
Trypanosoma brucei protein kinase, putative 0.0051 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0174 0.0179
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0048 0.0049
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0228 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Echinococcus multilocularis dna polymerase eta 0.0023 0.0057 0.0057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.011 0.0594 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0012 0.0516
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0516
Onchocerca volvulus 0.0159 0.0897 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0019 0.0068
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0255 0.0894
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.021 0.0679
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0168 0.0173
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0014 0.0597
Brugia malayi Thioredoxin reductase 0.005 0.022 0.0771
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0228 0.0228
Schistosoma mansoni mucolipin 0.0076 0.0385 0.0395
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0782 0.0804
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0168 0.1874
Brugia malayi ecdysteroid receptor 0.0041 0.0168 0.0589
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0168 0.0589
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.022 0.0226
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0019 0.0019
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0012 0.0041
Brugia malayi hypothetical protein 0.0019 0.0033 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0168 0.0589
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0169
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.022 0.9674
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0073 0.0364 0.0375
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0228 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0228 1
Echinococcus granulosus ornithine aminotransferase 0.0073 0.0364 0.0375
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.021 0.9214
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0019 0.0063
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0168 0.0173
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0513 0.3089 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0012 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0168 0.0589
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0033 0.0034
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0057 0.0059
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.0534 0.0534
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0033 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Echinococcus multilocularis mucolipin 3 0.0076 0.0385 0.0385
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0594 0.0611
Echinococcus granulosus expressed protein 0.0039 0.0155 0.0159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0168 0.0173
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1132 0.1132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0168 0.0173
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0019 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0019 0.0531
Treponema pallidum NADH oxidase 0.0017 0.0019 0.5
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0782 0.0782
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0255 0.0262
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.0323
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0168 0.0589
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0317 0.1877 0.6577
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0594 0.0594
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0033 0.0034
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.021 0.0679
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0019 0.0531
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0183 0.0594
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0614 0.1988
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0033 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0073 0.0364 0.118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0255 0.0262
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0168 0.1874
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0168 0.0589
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0228 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0168 0.0589
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0019 0.085
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0014 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0168 0.0589
Loa Loa (eye worm) hypothetical protein 0.0159 0.0897 0.3141
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0168 0.0173
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0228 0.0737
Brugia malayi hypothetical protein 0.0022 0.0048 0.0167
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0073 0.0364 0.118
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0019 0.002
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0168 0.0173
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0168 0.0173
Echinococcus multilocularis expressed conserved protein 0.0092 0.0484 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0168 0.0589
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0168 0.0168
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0168 0.0173
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0033 0.0116
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0228 1
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0033 0.0116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0255 0.0255
Leishmania major DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0073 0.0364 0.118
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0521 0.0536
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0048 0.0167
Loa Loa (eye worm) mucolipin 1 0.0076 0.0385 0.1348
Schistosoma mansoni hypothetical protein 0.0097 0.0513 0.0527
Brugia malayi Latrophilin receptor protein 2 0.01 0.0534 0.1872
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0003 0.0012
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.021 0.0679
Loa Loa (eye worm) glutathione reductase 0.005 0.022 0.0771
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0033 0.0116
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0183 0.3086
Brugia malayi MH2 domain containing protein 0.0017 0.0019 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0168 0.0589
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0019 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0168 0.0168
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0135 0.3696
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Schistosoma mansoni hypothetical protein 0.011 0.0594 0.0611
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0149 0.6537
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0073 0.0364 0.118
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0521 0.1826
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0168 0.0589
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0012 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0168 0.0589
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0057 0.0201
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0228 0.0234
Plasmodium falciparum ornithine aminotransferase 0.0073 0.0364 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0098 0.0521 0.1826
Brugia malayi conserved hypotetical protein 0.0019 0.0033 0.0116
Echinococcus multilocularis geminin 0.1584 0.9727 0.9727
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.053 0.0545
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0033 0.0116
Toxoplasma gondii thioredoxin reductase 0.005 0.022 0.6044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0019 0.085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0168 0.0589
Schistosoma mansoni hypothetical protein 0.01 0.0534 0.0549
Schistosoma mansoni hypothetical protein 0.0217 0.1256 0.1291
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0614 0.1988
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0149 0.2504
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0168 0.0589
Trypanosoma brucei glucosidase, putative 0.0044 0.0183 0.8056
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Brugia malayi tailless protein 0.0019 0.0033 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0168 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0397
Brugia malayi nuclear receptor NHR-88 0.0041 0.0168 0.0589
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0168 0.0173
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0019 0.0019
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0063
Echinococcus granulosus lamin dm0 0.0027 0.0082 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0183 0.8056
Brugia malayi hypothetical protein 0.0019 0.0033 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.1477 0.5176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0168 0.0589
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0155 0.0541
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0168 0.0173
Loa Loa (eye worm) hypothetical protein 0.0042 0.0174 0.0609
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.021 0.9214
Trypanosoma brucei unspecified product 0.0016 0.0012 0.0546
Echinococcus granulosus expressed conserved protein 0.0092 0.0484 0.0498
Echinococcus granulosus smad 0.0017 0.0019 0.002
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0012 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Schistosoma mansoni glutaminase 0.0287 0.169 0.1737
Onchocerca volvulus 0.0019 0.0033 0.0371
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Brugia malayi steroid hormone receptor 0.0041 0.0168 0.0589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0397
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0073 0.0364 0.118
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0033 0.0034
Brugia malayi ecdysone receptor 0.0019 0.0033 0.0116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Brugia malayi MH1 domain containing protein 0.0017 0.0019 0.0068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.021 0.0679
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0255 0.0255
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0019 0.0063
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0168 0.0168
Trypanosoma brucei unspecified product 0.0023 0.0057 0.2515
Echinococcus multilocularis GPCR, family 2 0.01 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0123 0.0677 0.2371
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0692 0.2241
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0397
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0614 0.1988
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0546
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0057 0.0057
Trichomonas vaginalis glutaminase, putative 0.0287 0.169 0.5471
Schistosoma mansoni patched 1 0.0042 0.0174 0.0179
Schistosoma mansoni lamin 0.0027 0.0082 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Mycobacterium ulcerans hypothetical protein 0.0048 0.021 0.0679
Plasmodium vivax thioredoxin reductase, putative 0.005 0.022 0.6044
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1132 0.3966
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.021 0.3529
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0082 0.0286
Echinococcus multilocularis protein patched 0.0042 0.0174 0.0174
Brugia malayi CHE-14 protein 0.0042 0.0174 0.0609
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0057 0.0201
Entamoeba histolytica hypothetical protein 0.011 0.0594 1
Loa Loa (eye worm) thioredoxin reductase 0.005 0.022 0.0771
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0521 0.8769
Loa Loa (eye worm) hypothetical protein 0.0052 0.0233 0.0815
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0168 0.0173
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0014 0.0044
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0168 0.1874
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0014 0.0597
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0057 0.0201
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0168 0.0173
Echinococcus granulosus microtubule associated protein 2 0.0759 0.4613 0.4743
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Echinococcus multilocularis Smad4 0.0017 0.0019 0.0019
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0019 0.085
Loa Loa (eye worm) hypothetical protein 0.0475 0.2854 1
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0073 0.0364 0.118
Echinococcus granulosus lamin 0.0027 0.0082 0.0084
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0073 0.0364 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0168 0.0173
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.0735
Schistosoma mansoni alpha glucosidase 0.0044 0.0183 0.0189
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0057 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0033 0.0034
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0073 0.0364 0.118
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0228 0.0797
Echinococcus multilocularis ornithine aminotransferase 0.0073 0.0364 0.0364
Echinococcus multilocularis ornithine aminotransferase 0.0073 0.0364 0.0364
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0057 0.2515
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0073 0.0364 0.118
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0019 0.002
Leishmania major trypanothione reductase 0.005 0.022 0.9674
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0168 0.0589
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0048 0.0049
Brugia malayi nuclear receptor RXR 0.0022 0.0048 0.0167
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0513 0.1797
Mycobacterium ulcerans acetylornithine aminotransferase 0.0073 0.0364 0.118
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0169
Schistosoma mansoni intermediate filament proteins 0.0027 0.0082 0.0084
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0057 0.2515
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0033 0.0116
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0033 0.0116
Leishmania major DNA polymerase eta, putative 0.0023 0.0057 0.2515
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0183 0.0183
Brugia malayi MH2 domain containing protein 0.0017 0.0019 0.0068
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0012 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0255 0.0262
Trichomonas vaginalis rotamase, putative 0.0039 0.0155 0.05
Loa Loa (eye worm) hypothetical protein 0.0317 0.1877 0.6577

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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