Detailed information for compound 131634

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 511.552 | Formula: C18H17N5O7S3
  • H donors: 3 H acceptors: 7 LogP: 1.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO/N=C(\c1csc(n1)N)/C(=O)N[C@@H]1C(=O)N2[C@@H]1CCC(=C2C(=O)O)S(=O)(=O)c1cccs1
  • InChi: 1S/C18H17N5O7S3/c1-30-22-12(8-7-32-18(19)20-8)15(24)21-13-9-4-5-10(14(17(26)27)23(9)16(13)25)33(28,29)11-3-2-6-31-11/h2-3,6-7,9,13H,4-5H2,1H3,(H2,19,20)(H,21,24)(H,26,27)/b22-12+/t9-,13+/m1/s1
  • InChiKey: GGCLVWLROZLNEA-JSPBKEIKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0006 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0017 0.0052
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0016 0.0145
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0094 0.0289
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0091 0.0091
Schistosoma mansoni polycystin 1-related 0.0021 0.0029 0.0062
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0288
Loa Loa (eye worm) aldehyde dehydrogenase 0.0014 0.0002 0.0004
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0048 0.0132 0.0406
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.112 0.4332 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0374 0.1003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0091 0.2411
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0171
Echinococcus granulosus cpg binding protein 0.0033 0.0073 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0056 0.1313
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0006 0.0044
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0016 0.0033
Schistosoma mansoni nAChR subunit 0.0018 0.0017 0.0035
Brugia malayi Cation transporter family protein 0.0018 0.0017 0.0052
Leishmania major hypothetical protein, conserved 0.0024 0.0039 0.0386
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0063 0.3386
Loa Loa (eye worm) hypothetical protein 0.066 0.2529 0.7765
Mycobacterium tuberculosis Probable sulfatase 0.0018 0.0016 0.0145
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0068 0.0211 0.0484
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0005
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0014 0.0002 0.0005
Brugia malayi Doublecortin family protein 0.0021 0.0029 0.0088
Brugia malayi Kringle domain containing protein 0.0024 0.0039 0.0119
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0197 0.0605
Trichomonas vaginalis rotamase, putative 0.0036 0.0086 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0423 0.0973
Echinococcus multilocularis nervana 2 0.0068 0.0211 0.0211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.0423 0.4385
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0006 0.0016
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0197 0.5258
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0016
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0029 0.0058 0.1527
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0102 0.0101
Onchocerca volvulus 0.0018 0.0017 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0094 0.0289
Onchocerca volvulus 0.0015 0.0006 0.0011
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0094 0.0094
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0182 0.0181
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0056 0.1461
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0094 0.0289
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0161
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0107 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0102 0.0231
Echinococcus granulosus expressed protein 0.0776 0.2985 0.2985
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0374 0.086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0016
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.004 0.0101 0.0307
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0014 0.0002 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0374 0.1003
Echinococcus granulosus tumor protein p63 0.0378 0.1425 0.1425
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0374 0.3876
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0109 0.0373 0.1145
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0249 0.0921 0.2826
Brugia malayi tailless protein 0.0018 0.0016 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0102 0.027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0288
Schistosoma mansoni survival motor neuron protein 0.0049 0.0136 0.031
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0238 1
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0102 0.0101
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0132 0.0406
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Chlamydia trachomatis endonuclease IV 0.0075 0.0238 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0091 0.0281
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0182 0.0558
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0068 0.0211 0.0211
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0374 0.1147
Schistosoma mansoni nAChR subunit 0.0018 0.0017 0.0035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0182 0.4254
Echinococcus granulosus axis inhibition protein axin 0.004 0.0102 0.0101
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0197 0.0197
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0017 0.0052
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0182 0.0485
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0039 0.0038
Onchocerca volvulus 0.0018 0.0017 0.0041
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0048 0.0132 0.0405
Brugia malayi hypothetical protein 0.0048 0.0132 0.0406
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.004 0.0122
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0311
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0017 0.0017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Echinococcus granulosus metabotropic glutamate receptor 2 0.0074 0.0237 0.0236
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0017 0.0017
Schistosoma mansoni intermediate filament proteins 0.0085 0.0279 0.0641
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0102 0.0312
Brugia malayi Sulfatase family protein 0.0018 0.0016 0.0048
Brugia malayi conserved hypotetical protein 0.0018 0.0016 0.0048
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0374 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0182 0.1874
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0017 0.0017
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.0115 0.0262
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0029 0.0028
Echinococcus granulosus lamin dm0 0.0085 0.0279 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Mycobacterium tuberculosis Possible hydrolase 0.0018 0.0016 0.0145
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0016 0.0015
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0565 0.2157 0.4977
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0017 0.0017
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.004 0.0122
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0002 0.0001
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0048 0.0132 0.3082
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0063 0.0062
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0061 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0102 0.0312
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0102 0.0312
Mycobacterium ulcerans sulfatase 0.0018 0.0016 0.0145
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0276 0.1026 0.1026
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0016 0.0145
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0374 0.1003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0094 0.0094
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0063 0.0062
Toxoplasma gondii microneme protein MIC4 0.0015 0.0006 0.0044
Schistosoma mansoni hypothetical protein 0.0024 0.0039 0.0086
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0068 0.0211 0.0211
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0017 0.0017
Mycobacterium ulcerans arylsulfatase, AslA 0.0018 0.0016 0.0145
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0006 0.0044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0094 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Schistosoma mansoni hypothetical protein 0.0182 0.0658 0.1516
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0016 0.0048
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0962 0.2219
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0086
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0048 0.0132 0.4959
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0091 0.0207
Onchocerca volvulus 0.0021 0.0029 0.0073
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0072 0.0191
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Mycobacterium ulcerans hydrolase 0.0018 0.0016 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Onchocerca volvulus 0.0015 0.0006 0.0011
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0068 0.0211 0.0211
Onchocerca volvulus 0.0048 0.0132 0.0352
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0024 0.0052
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0017 0.0052
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0102 0.0101
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0061 0.1568
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0136 0.0417
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0197 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0094 0.0288
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0374 0.3876
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0035 0.0082 0.0251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0094 0.0289
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0219 0.0502
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0017 0.0017
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0061 0.0622
Schistosoma mansoni rotamase 0.0036 0.0086 0.0195
Echinococcus granulosus voltage dependent calcium channel subunit 0.1168 0.4519 0.4518
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0006 0.0044
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0132 0.0406
Onchocerca volvulus 0.0015 0.0006 0.0011
Onchocerca volvulus 0.0962 0.3714 1
Schistosoma mansoni hypothetical protein 0.0021 0.0029 0.0062
Schistosoma mansoni coup transcription factor 0.0038 0.0094 0.0214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Onchocerca volvulus Poor gastrulation protein homolog 0.0014 0.0002 0.0001
Toxoplasma gondii subtilisin SUB12 0.0015 0.0006 0.0044
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0063 0.0192
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0016 0.0048
Toxoplasma gondii aldehyde dehydrogenase 0.026 0.0962 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0091 0.2411
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0046
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0016 0.0145
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0091 0.0242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0094 0.0289
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.008 0.026 0.08
Entamoeba histolytica hypothetical protein 0.004 0.0102 0.269
Brugia malayi Pre-SET motif family protein 0.0122 0.0423 0.1298
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0103 0.0103
Schistosoma mansoni lamin 0.0085 0.0279 0.0641
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0061 0.0161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0094 0.0289
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.0423 0.0422
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0288
Echinococcus multilocularis thyroid hormone receptor alpha 0.0314 0.1175 0.1174
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0182 0.0344
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0029 0.0028
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0017 0.0035
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0102 0.0101
Echinococcus multilocularis tumor protein p63 0.0378 0.1425 0.1425
Echinococcus multilocularis lamin 0.0085 0.0279 0.0279
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0403 0.0402
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0083 0.2179
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0103 0.0235
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0023 0.0218
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0094 0.0214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Schistosoma mansoni lipoxygenase 0.0021 0.0029 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0016
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0102 0.0101
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0091 0.0207
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0056 0.1313
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0039 0.0995
Brugia malayi nuclear receptor NHR-67 0.0018 0.0016 0.0048
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0056 0.1461
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0017 0.0052
Brugia malayi Aldehyde dehydrogenase protein 4 0.0014 0.0002 0.0005
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0039 0.085
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0121
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.004 0.0088
Schistosoma mansoni loxhd1 0.0021 0.0029 0.0062
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0048 0.0132 0.3082
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0006 0.0016
Toxoplasma gondii microneme protein, putative 0.0015 0.0006 0.0044
Brugia malayi PXA domain containing protein 0.004 0.0102 0.0312
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0018 0.0016 0.0038
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0132 0.3512
Echinococcus granulosus pikachurin 0.0024 0.004 0.0039
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0056 0.1263
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0094 0.0094
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0002 0.0001
Onchocerca volvulus 0.0015 0.0006 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0094 0.0214
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0014 0.0002 0.0001
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0029 0.0028
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0102 0.027
Onchocerca volvulus 0.0018 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0094 0.0094
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0017 0.0052
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0094 0.0094
Brugia malayi hypothetical protein 0.004 0.0102 0.0312
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0102 0.0312
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0109 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0085 0.0279 0.0856
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0374 1
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0238 0.246
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0061 0.1568
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0063 0.0634
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0017 0.0017
Plasmodium vivax thrombospondin-related anonymous protein 0.0048 0.0132 0.3082
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0039 0.0117
Echinococcus granulosus leukotriene A 4 hydrolase 0.0249 0.0921 0.092
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0102 0.027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0094 0.0289
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0962 0.2219
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0014 0.0002 0.0001
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0017 0.0017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0094 0.0214
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0094 0.025
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0016 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Brugia malayi hypothetical protein 0.0028 0.0056 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0073
Mycobacterium leprae conserved hypothetical protein 0.002 0.0023 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0094 0.0289
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.0423 0.0973
Entamoeba histolytica elongation factor-2 kinase, putative 0.0048 0.0132 0.3512
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0103 0.0103
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0091 0.2411
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0061 0.1391
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0016 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0374 0.1003
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1351 0.5237 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.0877 0.2693
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0288
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0016 0.0038
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0017 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Onchocerca volvulus 0.0038 0.0094 0.025
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0017 0.0035
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0043 0.0957
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0102 0.0101
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0094 0.0288
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0132 0.3512
Schistosoma mansoni hypothetical protein 0.0603 0.2307 0.5325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0094 0.0288
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0182 1
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0048 0.0132 0.0132
Brugia malayi Cache domain containing protein 0.0517 0.197 0.6049
Echinococcus granulosus intermediate filament protein 0.0085 0.0279 0.0279
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0018 0.0016 0.0038
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.003 0.0063 0.0194
Brugia malayi metabotropic glutamate receptor type 2 0.0043 0.0115 0.0353
Brugia malayi Cation transporter family protein 0.0018 0.0017 0.0052
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0016 0.0048
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0056 0.1461
Schistosoma mansoni serine-rich repeat protein 0.0603 0.2307 0.5325
Brugia malayi Na,K-ATPase alpha subunit 0.0035 0.0082 0.0252
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.0878 0.2694
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0238 0.6347
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0279 0.0856
Onchocerca volvulus 0.0015 0.0006 0.0011
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.004 0.0088
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0016 0.0145
Brugia malayi hypothetical protein 0.002 0.0024 0.0074
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0102 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0102 0.027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0094 0.0094
Entamoeba histolytica hypothetical protein 0.004 0.0103 0.2728
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0083 0.2179
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0094 0.025
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0014 0.0002 0.0001
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Loa Loa (eye worm) CUTiclin family member 0.0048 0.0132 0.0405
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0197 0.0197
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0182 0.0556
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0157
Onchocerca volvulus 0.0085 0.0279 0.0748
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0374 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0249 0.0921 0.2122
Schistosoma mansoni nuclear receptor 0.0018 0.0016 0.0033
Schistosoma mansoni hypothetical protein 0.0048 0.0132 0.0302
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0017 0.0051
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0048 0.0132 0.0352
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0017 0.0051
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.0423 0.0422
Echinococcus multilocularis nervana 2 0.0068 0.0211 0.0211
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0102 0.0312
Echinococcus granulosus metabotropic glutamate receptor 5 0.0109 0.0373 0.0373
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0006 0.0044
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0846 0.3257 1
Loa Loa (eye worm) hypothetical protein 0.0517 0.197 0.6048
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0374 0.0374
Onchocerca volvulus Putative nachr subunit 0.0018 0.0017 0.0041
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0005 0.0008
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0035 0.0082 0.0186
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0182 0.4834
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0016
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0029 0.0609
Brugia malayi 6-phosphofructokinase 0.0109 0.0374 0.1148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0046
Entamoeba histolytica hypothetical protein 0.004 0.0103 0.2728
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0182 0.731
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0061 0.0161
Schistosoma mansoni regulator of G protein signaling 0.004 0.0102 0.0231
Brugia malayi hypothetical protein 0.0253 0.0937 0.2877
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Schistosoma mansoni nAChR subunit 0.0018 0.0017 0.0035
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0035 0.0107
Toxoplasma gondii endonuclease IV APN 0.0075 0.0238 0.246
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0102 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0094 0.0094
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0068 0.0211 0.0484
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.026 0.0962 1
Echinococcus granulosus lamin 0.0085 0.0279 0.0279
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0017 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0094 0.0094
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0182 0.0485
Schistosoma mansoni cpg binding protein 0.0031 0.0066 0.015
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2568 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0094 0.0288
Brugia malayi nuclear receptor RXR 0.0018 0.0016 0.0048
Loa Loa (eye worm) DR-78 0.0018 0.0016 0.0047
Echinococcus multilocularis pikachurin 0.0024 0.004 0.0039
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0006 0.0044
Brugia malayi hypothetical protein 0.0238 0.0877 0.2694
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0094 0.0094
Schistosoma mansoni thyroid hormone receptor 0.0314 0.1175 0.2709
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0063 0.0191
Echinococcus multilocularis RUN 0.0021 0.0029 0.0028
Onchocerca volvulus 0.0048 0.0132 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Brugia malayi hypothetical protein 0.004 0.0102 0.0312
Echinococcus granulosus GPCR family 3 C terminal 0.0014 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0279 0.0856
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0102 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0017 0.0052
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0132 0.0406
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0094 0.0094
Echinococcus multilocularis nervana 2 0.0068 0.0211 0.0211
Brugia malayi nuclear hormone receptor 0.0038 0.0094 0.0289
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0132 0.0406
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0035 0.0105
Brugia malayi Cytochrome P450 family protein 0.007 0.0219 0.0674
Schistosoma mansoni zinc finger protein 0.0018 0.0016 0.0033
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0083 0.2179
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0055 0.0162 0.0497
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.003 0.0063 0.0193
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0132 0.0406
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0311
Brugia malayi nuclear receptor NHR-88 0.0018 0.0016 0.0048
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.004 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.011 0.0293
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Toxoplasma gondii microneme protein MIC2 0.0048 0.0132 0.1361
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.087 0.3354 0.3354
Schistosoma mansoni DNA helicase recq5 0.003 0.0063 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0311
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0276 0.1026 0.1026
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0017 0.0017
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0016 0.0015
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0197 0.2038
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0017 0.0052
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0017 0.0052
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0197 0.0452
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0072 0.0737
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0016 0.0015
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0091 0.4987
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0962 1
Schistosoma mansoni regulator of G protein signaling 0.004 0.0102 0.0231
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0105
Echinococcus multilocularis bloom syndrome protein 0.0042 0.011 0.011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0094 0.0289
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0238 0.0731
Brugia malayi hypothetical protein 0.0021 0.0029 0.0088
Schistosoma mansoni rab6-interacting 0.0021 0.0029 0.0062
Schistosoma mansoni axis inhibition protein axin 0.004 0.0102 0.0231
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0162 0.0371
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0132 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0091 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0102 0.027
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0017 0.0017
Brugia malayi hypothetical protein 0.0021 0.0029 0.0088
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.01 0.3434
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0016 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0094 0.0289
Schistosoma mansoni nAChR subunit 0.0018 0.0017 0.0035
Brugia malayi PXA domain containing protein 0.004 0.0102 0.0312
Brugia malayi steroid hormone receptor 0.0038 0.0094 0.0289
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0288
Brugia malayi ecdysone receptor 0.0018 0.0016 0.0048
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0017 0.0017
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0017 0.001 0.002
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0017 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0094 0.0289
Onchocerca volvulus 0.0085 0.0279 0.0748
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0017 0.0017
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0014 0.0002 0.0001
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0091 0.0091
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0006 0.0044
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0091 0.0242
Brugia malayi hypothetical protein 0.0018 0.0016 0.0048
Schistosoma mansoni hypothetical protein 0.004 0.0103 0.0235
Brugia malayi nuclear receptor NHR-88 0.0038 0.0094 0.0289
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0074 0.0237 0.0236
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0016 0.0015
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0017 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Treponema pallidum ATP-dependent DNA helicase 0.0015 0.0005 0.0007
Onchocerca volvulus 0.0049 0.0136 0.0361
Brugia malayi Metabotropic glutamate receptor precursor. 0.0089 0.0293 0.09
Brugia malayi aldehyde dehydrogenase 0.0014 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0276 0.1026 0.2366
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0073
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0192 0.198
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0311
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0039 0.0386
Schistosoma mansoni transmemberane protein 0.0068 0.0211 0.0484
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0091 0.0091
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0017 0.0017
Mycobacterium ulcerans endonuclease IV 0.0075 0.0238 0.246
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0094 0.0214
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0962 1
Echinococcus granulosus geminin 0.0182 0.0658 0.0657
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0072 0.1902
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0107 0.0106
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0017 0.0051
Onchocerca volvulus 0.0018 0.0017 0.0041
Schistosoma mansoni nuclear receptor 0.0018 0.0016 0.0033
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0374 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0075 0.0238 0.0729
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0132 0.0406
Brugia malayi intermediate filament protein 0.0085 0.0279 0.0857
Echinococcus granulosus RUN 0.0021 0.0029 0.0028
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.026 0.0962 1
Schistosoma mansoni metabotropic glutamate receptor 0.0074 0.0237 0.0543
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Treponema pallidum hypothetical protein 0.0048 0.0132 0.025
Echinococcus granulosus axis inhibition protein axin 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0016
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0102 0.0101
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0374 0.0711
Onchocerca volvulus 0.0031 0.0066 0.0174
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0311
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0094 0.0214
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0094 0.0094
Echinococcus granulosus nAChR subunit 0.0018 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0182 0.0658 0.1516
Schistosoma mansoni regulator of G protein signaling 0.004 0.0102 0.0231
Loa Loa (eye worm) glutamate receptor 0.0035 0.0082 0.0251
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0035 0.0105
Echinococcus granulosus collagen alpha 1VII chain 0.0048 0.0132 0.0132
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0003 0.0037
Onchocerca volvulus 0.0015 0.0006 0.0011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0005 0.0038
Brugia malayi nuclear hormone receptor 0.0018 0.0016 0.0048
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0061 0.1605
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0102 0.0101
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0016 0.0033
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0029 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0094 0.0289
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0124 0.038
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0072 0.1902
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0288
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0091 0.0091
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0029 0.0028
Brugia malayi von Willebrand Factor 0.0048 0.0132 0.0406
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0102 0.0231
Echinococcus granulosus expressed protein 0.0036 0.0086 0.0086
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0083 0.0845
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0182 0.4834
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0102 0.027
Schistosoma mansoni hypothetical protein 0.0049 0.0136 0.031
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0197 0.5258
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0091 0.2411
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0016 0.0047
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0048 0.0132 0.0405
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0006 0.0044
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0374 0.0374
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0017 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0016 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0068 0.0211 0.0211
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0061 0.0161
Onchocerca volvulus 0.0048 0.0132 0.0352
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Schistosoma mansoni thyroid hormone receptor 0.0314 0.1175 0.2709
Onchocerca volvulus 0.0015 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0107 0.0326
Schistosoma mansoni hypothetical protein 0.0048 0.0132 0.0302
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0092
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0086 0.0263
Echinococcus granulosus nervana 2 0.0068 0.0211 0.0211
Toxoplasma gondii hypothetical protein 0.0015 0.0006 0.0044
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0014 0.0002 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0423 0.0973
Echinococcus granulosus Na:K ATPase alpha subunit 0.0035 0.0082 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0423 0.0973
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0068 0.0211 0.0484
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.011 0.0293
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Schistosoma mansoni cell polarity protein 0.0024 0.004 0.0088
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0068 0.0211 0.0211
Brugia malayi follicle stimulating hormone receptor 0.0238 0.0878 0.2695
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0102 0.0101
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0035 0.0082 0.0186
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0288
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0017 0.0051
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0083 0.0845
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0006 0.0044
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0017 0.0017
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0124 0.0382
Loa Loa (eye worm) RecQ helicase 0.0042 0.011 0.0337
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0094 0.0289
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0016 0.0015
Brugia malayi hypothetical protein 0.0114 0.0394 0.1209
Onchocerca volvulus 0.0048 0.0132 0.0352
Echinococcus multilocularis expressed protein 0.0036 0.0086 0.0086
Onchocerca volvulus 0.0015 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Echinococcus multilocularis nervana 2 0.0068 0.0211 0.0211
Mycobacterium ulcerans epimerase 0.002 0.0023 0.0218
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0102 0.0101
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0068 0.0211 0.0484
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0102 0.0231
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0024 0.0073
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0017 0.0052
Brugia malayi Pre-SET motif family protein 0.0846 0.3257 1
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0091 0.0091
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0006 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0094 0.0214
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.004 0.0121
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0091 0.0091
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0063 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0094 0.0214
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0016 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0094 0.025
Loa Loa (eye worm) RGS-3 protein 0.004 0.0102 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Onchocerca volvulus 0.0021 0.0029 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Schistosoma mansoni slit 0.0024 0.004 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0017 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0102 0.0311
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Echinococcus granulosus nervana 2 0.0068 0.0211 0.0211
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0006 0.0044
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0035 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0073
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.1665 0.1664
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0023 0.0069
Onchocerca volvulus 0.0015 0.0006 0.0011
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0005 0.0098
Loa Loa (eye worm) hypothetical protein 0.0068 0.0211 0.0647
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Trichomonas vaginalis rotamase, putative 0.0035 0.0083 0.0219
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0073
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0048 0.0132 0.1361
Schistosoma mansoni lamin 0.0085 0.0279 0.0641
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0029 0.0028
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0006 0.0044
Leishmania major hypothetical protein, conserved 0.0028 0.0056 0.0566
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0094 0.0094
Entamoeba histolytica hypothetical protein 0.004 0.0103 0.2728
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0018 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0101 0.0307
Treponema pallidum 76K protein 0.0048 0.0132 0.025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0182 0.4834
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0016 0.0048
Onchocerca volvulus 0.0068 0.0211 0.0565
Brugia malayi Protein kinase domain containing protein 0.0024 0.0039 0.0119
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0102 0.0101
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0017 0.0017
Brugia malayi hypothetical protein 0.002 0.0024 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0102 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0962 1
Brugia malayi EGF-like domain containing protein 0.0024 0.004 0.0122
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0091 0.0091
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0374 0.3876
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0041 0.0409
Brugia malayi CXXC zinc finger family protein 0.0031 0.0066 0.0204
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0061 0.0622
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0034 0.0077 0.0788
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0039 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0094 0.0288
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0374 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0024 0.0074
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0094 0.0094
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.026 0.0962 0.0962
Schistosoma mansoni regulator of G protein signaling 0.004 0.0102 0.0231
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0877 0.0877
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.011 0.0339
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0102 0.0101
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0132 0.0406
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1168 0.4519 0.4518
Loa Loa (eye worm) CUTiclin-Like family member 0.0048 0.0132 0.0405
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.026 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0102 0.0311
Brugia malayi Cation transporter family protein 0.0018 0.0017 0.0052
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Plasmodium vivax SET domain protein, putative 0.0122 0.0423 1
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0016 0.0048
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0068 0.0211 0.0211
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0063 0.0192
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0017 0.0052
Schistosoma mansoni DNA helicase recq1 0.003 0.0063 0.0141
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0024 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.0423 0.0422
Loa Loa (eye worm) hypothetical protein 0.0037 0.0091 0.0279
Schistosoma mansoni axis inhibition protein axin 0.004 0.0102 0.0231
Echinococcus multilocularis expressed protein 0.0776 0.2985 0.2985
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0094 0.0289
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0014 0.0002 0.0006
Schistosoma mansoni cpg binding protein 0.0033 0.0073 0.0165
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0017 0.0017
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0101 0.0341 0.0783
Plasmodium falciparum thrombospondin-related anonymous protein 0.0048 0.0132 0.4959
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0083 0.2179
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0094 0.0214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0251
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0102 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Onchocerca volvulus 0.0034 0.0077 0.0204
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0063 0.0634
Giardia lamblia Hypothetical protein 0.0018 0.0016 0.0775
Brugia malayi phosphofructokinase 0.0109 0.0374 0.1148
Schistosoma mansoni lipoxygenase 0.0059 0.0178 0.0407
Onchocerca volvulus 0.0048 0.0132 0.0352
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0016 0.0033
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0017 0.0035
Toxoplasma gondii hypothetical protein 0.0015 0.0006 0.0044
Mycobacterium ulcerans arylsulfatase AtsB 0.0018 0.0016 0.0145
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0039 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0102 0.0231
Trichomonas vaginalis set domain proteins, putative 0.0962 0.3714 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0017 0.0035
Entamoeba histolytica hypothetical protein 0.004 0.0103 0.2728
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0374 0.1147
Entamoeba histolytica hypothetical protein 0.0048 0.0132 0.3512
Echinococcus multilocularis slit 2 protein 0.0024 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0121
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0005 0.0098
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0073
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0023 0.0218
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0016 0.0015
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0182 1
Entamoeba histolytica hypothetical protein 0.004 0.0102 0.269
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0016 0.0015
Mycobacterium ulcerans hypothetical protein 0.002 0.0023 0.0218
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0837
Echinococcus multilocularis geminin 0.0182 0.0658 0.0657
Loa Loa (eye worm) hypothetical protein 0.0122 0.0423 0.1297
Schistosoma mansoni nAChR subunit 0.0018 0.0017 0.0035
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0178 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0094 0.0288
Echinococcus multilocularis nAChR subunit 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0068 0.0211 0.0647
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0102 0.0311
Giardia lamblia Hypothetical protein 0.0018 0.0016 0.0775
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0061 0.0161
Brugia malayi hypothetical protein 0.0018 0.0017 0.0052
Echinococcus multilocularis lamin dm0 0.0085 0.0279 0.0279
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0017 0.0017
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0068 0.0211 0.0211
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0051 0.0113
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0091 0.0934
Onchocerca volvulus 0.0122 0.0423 0.1135
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0005 0.0098
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0016 0.0015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0197 0.5258
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0016 0.0033
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0063 0.0062
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0086
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0182 0.1874
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0014 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0038
Onchocerca volvulus 0.0024 0.0039 0.01
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0056 0.0566
Schistosoma mansoni hypothetical protein 0.0014 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0016
Schistosoma mansoni cpg binding protein 0.0033 0.0073 0.0165
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0066 0.0202
Onchocerca volvulus 0.0048 0.0132 0.0352
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0063 0.1625
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0094 0.0094
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0023 0.0056
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0374 0.086
Onchocerca volvulus 0.0068 0.0211 0.0565
Echinococcus multilocularis cpg binding protein 0.0033 0.0073 0.0073
Schistosoma mansoni ap endonuclease 0.006 0.0182 0.0416
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0091 0.0091
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0094 0.0094
Echinococcus granulosus dnaJ subfamily B 0.0439 0.1665 0.1664
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0072 0.1902
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0182 0.4834
Onchocerca volvulus 0.0015 0.0006 0.0011
Brugia malayi hypothetical protein 0.0018 0.0016 0.0048
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0374 0.1147
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0132 0.0406
Schistosoma mansoni regulator of G protein signaling 0.004 0.0102 0.0231
Onchocerca volvulus 0.0048 0.0132 0.0352
Schistosoma mansoni nAChR subunit 0.0018 0.0017 0.0035
Brugia malayi nuclear receptor RXR 0.002 0.0024 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0132 0.3082
Onchocerca volvulus 0.0018 0.0017 0.0041
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Brugia malayi laminin alpha chain 0.0024 0.004 0.0122
Toxoplasma gondii exonuclease III APE 0.006 0.0182 0.1874
Loa Loa (eye worm) glutamate receptor 0.0089 0.0293 0.0899
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0061 0.0622
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0086 0.0264
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0048 0.0132 0.3082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0094 0.0288
Schistosoma mansoni nAChR subunit 0.0018 0.0017 0.0035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0094 0.0094
Onchocerca volvulus 0.0018 0.0017 0.0041
Entamoeba histolytica hypothetical protein 0.004 0.0102 0.269
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0006 0.0016
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0029 0.0028
Schistosoma mansoni ap endonuclease 0.006 0.0182 0.0416
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0182 0.1874
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0094 0.0288
Brugia malayi ecdysteroid receptor 0.0038 0.0094 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0094 0.0289
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0035 0.0082 0.4474
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.0439 0.1665 0.3841
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0061 0.3321
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0117
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0219 0.0672
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0094 0.0214
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0178 0.0177
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0238 0.5596
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0014 0.0002 0.0001
Schistosoma mansoni rab6-interacting 0.0021 0.0029 0.0062
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0197 0.5258
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0877 0.0877
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0024 0.0074
Echinococcus granulosus slit 2 protein 0.0024 0.004 0.0039
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0048 0.0132 0.4959
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0094 0.0289
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0014 0.0002 0.0001
Onchocerca volvulus 0.0018 0.0016 0.0038
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0017 0.0052
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0068 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0061 0.0114
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0279 0.0857
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0016 0.0047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0405
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0024 0.0052
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0132 0.0406
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0191
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0051
Echinococcus granulosus nervana 2 0.0068 0.0211 0.0211
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0016 0.0048
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0132 0.0406
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0102 0.0101
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0061 0.1391
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0061 0.0161
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0068
Echinococcus multilocularis musashi 0.0085 0.0279 0.0279
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0102 0.0231
Echinococcus multilocularis GPCR, family 3, C terminal 0.0014 0.0002 0.0002
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0014 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0017 0.0017
Brugia malayi hypothetical protein 0.004 0.0103 0.0317
Onchocerca volvulus 0.0055 0.0162 0.0433
Onchocerca volvulus 0.0018 0.0016 0.0038
Echinococcus granulosus bloom syndrome protein 0.0042 0.011 0.011
Brugia malayi PAN domain containing protein 0.0015 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0086 0.0227
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.004 0.0039
Brugia malayi 6-phosphofructokinase 0.0109 0.0374 0.1148
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0016 0.0038
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0102 0.0231
Brugia malayi hypothetical protein 0.0018 0.0016 0.0048
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0249 0.0921 0.092
Onchocerca volvulus 0.0015 0.0006 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0061 0.0161
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0102 0.0101
Echinococcus granulosus nervana 2 0.0068 0.0211 0.0211

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.015 ug ml-1 Minimum inhibitory concentration of the compound against Streptococcus pyogenes (C203) ChEMBL. 2810332
MIC (functional) = 0.03 ug ml-1 Minimum inhibitory concentration of the compound against Streptococcus pneumoniae (PARK) ChEMBL. 2810332
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory concentration of the compound against Salmonella (X514) ChEMBL. 2810332
MIC (functional) = 1 ug ml-1 Minimum inhibitory concentration of the compound against Haemophilus influenzae (C.L.) ChEMBL. 2810332
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration of the compound against Escherichia coli (EC14) ChEMBL. 2810332
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration of the compound against Klebsiella (X26) ChEMBL. 2810332
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration of the compound against Escherichia coli (EC14) ChEMBL. 2810332
MIC (functional) = 4 ug ml-1 Minimum inhibitory concentration of the compound against Staphylococcus aureus (X1.1) ChEMBL. 2810332
MIC (functional) = 8 ug ml-1 Minimum inhibitory concentration of the compound against Enterobacter cloacae (EB5) ChEMBL. 2810332
MIC (functional) = 16 ug ml-1 Minimum inhibitory concentration of the compound against Staphylococcus epidermidis (222) ChEMBL. 2810332
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound against Proteus morganii (PR 15) ChEMBL. 2810332
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound against Proteus rettgeri (C24) ChEMBL. 2810332
MIC (functional) = 128 ug ml-1 Minimum inhibitory concentration of the compound against Escherichia coli (TEM beta-lactamase containing) ChEMBL. 2810332
MIC (functional) > 128 ug ml-1 Minimum inhibitory concentration of the compound against Klebsiella (KAE beta-lactamase containing) ChEMBL. 2810332
MIC (functional) > 128 ug ml-1 Minimum inhibitory concentration of the compound against Enterobacter cloacae (265A beta-lactamase containing) ChEMBL. 2810332
MIC (functional) > 128 ug ml-1 Minimum inhibitory concentration of the compound against Pseudomonas aeruginosa (X528) ChEMBL. 2810332
MIC (functional) = 128 ug ml-1 Minimum inhibitory concentration of the compound against Escherichia coli (TEM beta-lactamase containing) ChEMBL. 2810332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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