Detailed information for compound 1322977

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.403 | Formula: C23H20O4
  • H donors: 0 H acceptors: 0 LogP: 5.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1CC(Oc2c1cc1OCOc1c2)c1ccccc1
  • InChi: 1S/C23H20O4/c1-24-17-9-7-15(8-10-17)18-11-20(16-5-3-2-4-6-16)27-21-13-23-22(12-19(18)21)25-14-26-23/h2-10,12-13,18,20H,11,14H2,1H3
  • InChiKey: YQRRFKSPYWIJGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0215 0.0205
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Brugia malayi cathepsin B-like cysteine proteinase 0.0288 0.2975 0.683
Loa Loa (eye worm) hypothetical protein 0.0298 0.3081 0.7046
Loa Loa (eye worm) thymidylate synthase 0.0108 0.1007 0.224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0046 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Plasmodium falciparum plasmepsin III 0.0037 0.0234 0.1338
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0697 0.4308
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0108 0.1007 0.2665
Plasmodium falciparum cysteine proteinase falcipain 2a 0.007 0.0589 0.3784
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0012
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0449
Schistosoma mansoni thyroid hormone receptor 0.002 0.0046 0.0005
Brugia malayi Pre-SET motif family protein 0.0059 0.0475 0.1091
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0234 0.1338
Entamoeba histolytica cysteine proteinase 1, putative 0.004 0.0263 0.0362
Onchocerca volvulus 0.007 0.0589 0.1109
Brugia malayi Common central domain of tyrosinase family protein 0.0189 0.1896 0.4353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Loa Loa (eye worm) cysteine protease 0.007 0.0589 0.127
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0131
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Loa Loa (eye worm) ShTK domain-containing protein 0.0189 0.1896 0.43
Schistosoma mansoni dihydrofolate reductase 0.0044 0.0307 0.0268
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0152 0.1489 1
Echinococcus multilocularis cathepsin b 0.0288 0.2975 0.3445
Loa Loa (eye worm) RNA binding protein 0.0125 0.119 0.2664
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.019 0.0244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0116 0.0267
Schistosoma mansoni hypothetical protein 0.0334 0.3476 0.345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Onchocerca volvulus 0.007 0.0589 0.1109
Onchocerca volvulus 0.0472 0.4982 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0097 0.0391
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0263 0.0757
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.4356 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Trypanosoma cruzi cysteine peptidase, putative 0.0116 0.1095 0.3595
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 0.2975 0.2947
Brugia malayi Cathepsin L-like precursor 0.0049 0.0366 0.0841
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.6188 1
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0263 0.0603
Trypanosoma brucei glucosidase, putative 0.0036 0.0215 0.0847
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.038 0.0687
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0103 0.0948 0.6114
Echinococcus multilocularis cathepsin L 0.004 0.0263 0.0261
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0017
Trypanosoma cruzi cysteine proteinase, putative 0.004 0.0263 0.0757
Echinococcus granulosus tar DNA binding protein 0.0125 0.119 0.2412
Echinococcus multilocularis cathepsin L cysteine protease 0.007 0.0589 0.0643
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1581 0.3231
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0097 0.0193
Trypanosoma cruzi cysteine proteinase, putative 0.004 0.0263 0.0757
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0046 0.0006
Brugia malayi Cathepsin L-like precursor 0.0049 0.0366 0.0841
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0288 0.2975 0.2947
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0046 0.0006
Loa Loa (eye worm) ctsf protein 0.007 0.0589 0.127
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0697 0.1377
Echinococcus granulosus intermediate filament protein 0.0027 0.0116 0.0159
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.119 0.2664
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.0388 0.1183
Echinococcus multilocularis musashi 0.0027 0.0116 0.0089
Onchocerca volvulus 0.002 0.0046 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.007 0.0589 0.055
Trypanosoma cruzi cruzipain precursor, putative 0.0116 0.1095 0.3595
Echinococcus granulosus transcription factor Dp 1 0.0046 0.033 0.0607
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1419 0.3259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.6188 1
Echinococcus granulosus cathepsin L 0.004 0.0263 0.0466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0215 0.0284
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0046 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.019 0.0244
Echinococcus multilocularis lamin 0.0027 0.0116 0.0089
Schistosoma mansoni chromobox protein 0.0084 0.0745 0.0707
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0449
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.0388 0.0306
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Echinococcus granulosus dihydrofolate reductase 0.0044 0.0307 0.056
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0234 0.1338
Toxoplasma gondii aspartyl protease 0.0037 0.0234 0.1338
Loa Loa (eye worm) hypothetical protein 0.0189 0.1896 0.43
Echinococcus granulosus geminin 0.0334 0.3476 0.7208
Plasmodium falciparum plasmepsin I 0.0037 0.0234 0.1338
Brugia malayi Pepsin A precursor 0.0037 0.0234 0.0538
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0215 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Brugia malayi nuclear receptor NHR-88 0.002 0.0046 0.0105
Brugia malayi TAR-binding protein 0.0125 0.119 0.2733
Echinococcus multilocularis chromobox protein 1 0.0084 0.0745 0.0827
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0234 0.0227
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.0059 0.0475 0.1008
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.004 0.0263 0.0757
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0012
Onchocerca volvulus Huntingtin homolog 0.0121 0.1145 0.2236
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Brugia malayi steroid hormone receptor 0.002 0.0046 0.0105
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0234 0.0449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.6188 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.007 0.0589 0.115
Loa Loa (eye worm) hypothetical protein 0.0049 0.0366 0.0755
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0046 0.0006
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0294 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0046 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0103 0.0948 0.1477
Onchocerca volvulus 0.0189 0.1896 0.3755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0263 0.0362
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0234 0.1338
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0294 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0215 0.0284
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0215 0.0405
Loa Loa (eye worm) hypothetical protein 0.0147 0.1435 0.3231
Plasmodium falciparum cysteine proteinase falcipain 3 0.007 0.0589 0.3784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0046 0.0012
Onchocerca volvulus Cathepsin F homolog 0.007 0.0589 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0046 0.0105
Onchocerca volvulus 0.007 0.0589 0.1109
Plasmodium vivax aspartyl protease, putative 0.0037 0.0234 0.1338
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0215 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0318 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1419 0.1618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Brugia malayi hypothetical protein 0.0121 0.1145 0.2629
Brugia malayi Cathepsin L-like precursor 0.007 0.0589 0.1351
Plasmodium vivax aspartyl protease, putative 0.0037 0.0234 0.1338
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0475 0.3003
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.004 0.0093
Loa Loa (eye worm) hypothetical protein 0.0288 0.2975 0.6801
Leishmania major cathepsin L-like protease 0.007 0.0589 0.3531
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0294 0.1753
Brugia malayi nuclear hormone receptor 0.002 0.0046 0.0105
Leishmania major cathepsin L-like protease 0.007 0.0589 0.3531
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.119 0.2733
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0189 0.1896 0.4353
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0284 0.2933 1
Brugia malayi cathepsin L precursor 0.002 0.004 0.0093
Echinococcus multilocularis muscleblind protein 0.0147 0.1435 0.1636
Echinococcus multilocularis cysteine protease 0.007 0.0589 0.0643
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0363 0.0747
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0263 0.0362
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0046 0.0005
Plasmodium falciparum plasmepsin VII 0.0037 0.0234 0.1338
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0046 0.0105
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0048 0.011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0318 0.0644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0046 0.0011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0284 0.2933 1
Leishmania major cathepsin L-like protease 0.0116 0.1095 0.7173
Plasmodium falciparum cysteine proteinase falcipain 2b 0.007 0.0589 0.3784
Plasmodium falciparum plasmepsin IX 0.0037 0.0234 0.1338
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0152 0.1489 0.4935
Trypanosoma cruzi cruzipain precursor, putative 0.002 0.0048 0.0025
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0046 0.0011
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0189 0.1896 0.4353
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0125 0.119 0.1155
Loa Loa (eye worm) hypothetical protein 0.0147 0.1435 0.3231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0046 0.0105
Plasmodium falciparum plasmepsin V 0.0037 0.0234 0.1338
Brugia malayi fibroinase precursor 0.002 0.004 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0626 0.0588
Brugia malayi chromobox protein homolog 3 0.0047 0.0341 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0341 0.0489
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0215 0.0595
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0108 0.1007 0.2665
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0745 0.1632
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0046 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0097 0.0391
Entamoeba histolytica cysteine protease, putative 0.007 0.0589 0.0892
Echinococcus granulosus chromobox protein 1 0.0084 0.0745 0.1478
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0215 0.0847
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.002 0.0048 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0263 0.0223
Plasmodium falciparum plasmepsin II 0.0037 0.0234 0.1338
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0193 0.0442
Schistosoma mansoni tyrosinase precursor 0.0189 0.1896 0.1863
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.004 0.0093
Brugia malayi Papain family cysteine protease containing protein 0.002 0.004 0.0093
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1375 0.2799
Schistosoma mansoni alpha-glucosidase 0.0138 0.1336 0.1301
Echinococcus granulosus cathepsin l cysteine peptidase 0.007 0.0589 0.115
Schistosoma mansoni tar DNA-binding protein 0.0125 0.119 0.1155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.6188 1
Onchocerca volvulus 0.0189 0.1896 0.3755
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0046 0.0105
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1435 0.1636
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0103 0.0948 0.0911
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0046 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0097 0.0193
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0234 0.0315
Leishmania major cathepsin L-like protease 0.007 0.0589 0.3531
Brugia malayi dihydrofolate reductase family protein 0.0044 0.0307 0.0706
Trypanosoma cruzi cysteine protease, putative 0.004 0.0263 0.0757
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0152 0.1489 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.007 0.0589 0.127
Onchocerca volvulus Cathepsin L homolog 0.007 0.0589 0.1109
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0449
Mycobacterium ulcerans thymidylate synthase 0.0108 0.1007 0.2665
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1581 0.1808
Echinococcus multilocularis neuropeptide receptor A26 0.0456 0.4807 0.5594
Plasmodium vivax unspecified product 0.002 0.0048 0.0051
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0697 0.2236
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0046 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1138 0.2544
Echinococcus multilocularis cathepsin l cysteine peptidase 0.007 0.0589 0.0643
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0366 0.053
Brugia malayi Cathepsin L-like precursor 0.007 0.0589 0.1351
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1581 0.3569
Schistosoma mansoni tar DNA-binding protein 0.0125 0.119 0.1155
Echinococcus granulosus lamin 0.0027 0.0116 0.0159
Loa Loa (eye worm) hypothetical protein 0.0189 0.1896 0.43
Schistosoma mansoni alpha-glucosidase 0.0138 0.1336 0.1301
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0215 0.0284
Echinococcus granulosus lamin dm0 0.0027 0.0116 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.6188 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0046 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0318 0.0326
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 0.2975 0.2947
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0046 0.0105
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0046 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0745 0.1146
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0189 0.1896 0.4353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0046 0.0012
Echinococcus multilocularis geminin 0.0334 0.3476 0.4033
Plasmodium vivax SET domain protein, putative 0.0059 0.0475 0.3003
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.0589 0.127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0046 0.0105
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0234 0.0538
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0547 0.1727
Treponema pallidum fructose-bisphosphate aldolase 0.0582 0.6188 0.5
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0017
Brugia malayi ShTK domain containing protein 0.0189 0.1896 0.4353
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0341 0.0608
Loa Loa (eye worm) cathepsin B 0.0103 0.0948 0.2103
Loa Loa (eye worm) hypothetical protein 0.0121 0.1145 0.256
Plasmodium falciparum cysteine proteinase falcipain 1 0.004 0.0263 0.1534
Onchocerca volvulus 0.0073 0.0626 0.1185
Brugia malayi Papain family cysteine protease containing protein 0.002 0.004 0.0093
Echinococcus granulosus muscleblind protein 0.0147 0.1435 0.2925
Loa Loa (eye worm) acetyltransferase 0.0146 0.1419 0.3195
Toxoplasma gondii cathepsin CPL 0.007 0.0589 0.3784
Loa Loa (eye worm) fibroinase 0.007 0.0589 0.127
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0215 0.0366
Echinococcus granulosus neuropeptide receptor A26 0.0456 0.4807 1
Echinococcus multilocularis cathepsin L cysteine protease 0.007 0.0589 0.0643
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0294 0.1753
Giardia lamblia Cathepsin B precursor 0.0103 0.0948 0.1477
Brugia malayi MH2 domain containing protein 0.012 0.1138 0.2613
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0116 0.0175
Schistosoma mansoni lamin 0.0027 0.0116 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0046 0.0105
Plasmodium vivax vivapain-3 0.004 0.0263 0.1534
Schistosoma mansoni tyrosinase precursor 0.0189 0.1896 0.1863
Echinococcus multilocularis tar DNA binding protein 0.0125 0.119 0.135
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Plasmodium falciparum plasmepsin IV 0.0037 0.0234 0.1338
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0255 0.0349
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.033 0.034
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0475 0.0913
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0012
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0046 0.001
Brugia malayi hypothetical protein 0.0037 0.0234 0.0538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0263 0.0362
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0263 0.0362
Schistosoma mansoni intermediate filament proteins 0.0027 0.0116 0.0076
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0294 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0046 0.0012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0215 0.0284
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0046 0.0006
Onchocerca volvulus Huntingtin homolog 0.0121 0.1145 0.2236
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.0438
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0097 0.0391
Onchocerca volvulus Cathepsin L homolog 0.007 0.0589 0.1109
Entamoeba histolytica cysteine proteinase, putative 0.007 0.0589 0.0892
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0697 0.1599
Echinococcus granulosus neuropeptide s receptor 0.0456 0.4807 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0046 0.0105
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0263 0.0223
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0255 0.1483
Brugia malayi hypothetical protein 0.0016 0.0001 0.0002
Brugia malayi Cathepsin L-like precursor 0.007 0.0589 0.1351
Brugia malayi Cathepsin L-like precursor 0.007 0.0589 0.1351
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0048 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0046 0.001
Loa Loa (eye worm) hypothetical protein 0.0049 0.0366 0.0755
Plasmodium vivax unspecified product 0.004 0.0263 0.1534
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0046 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0341 0.0489
Echinococcus granulosus cathepsin l1 0.007 0.0589 0.115
Onchocerca volvulus 0.0093 0.0841 0.1619
Plasmodium vivax vivapain-2 0.007 0.0589 0.3784
Brugia malayi intermediate filament protein 0.0027 0.0116 0.0267
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0234 0.1338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Plasmodium falciparum plasmepsin VI 0.0037 0.0234 0.1338
Loa Loa (eye worm) dihydrofolate reductase 0.0044 0.0307 0.0619
Onchocerca volvulus 0.0189 0.1896 0.3755
Brugia malayi RNA binding protein 0.0125 0.119 0.2733
Brugia malayi hypothetical protein 0.0298 0.3081 0.7073
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0215 0.0494
Giardia lamblia Fructose-bisphosphate aldolase 0.0582 0.6188 1
Echinococcus multilocularis lamin dm0 0.0027 0.0116 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0697 0.0659
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0046 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.007 0.0589 0.0892
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0046 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0012
Loa Loa (eye worm) tyrosinase 1 0.0189 0.1896 0.43
Schistosoma mansoni cathepsin s 0.002 0.0048 0.0007
Loa Loa (eye worm) TAR-binding protein 0.0125 0.119 0.2664
Onchocerca volvulus 0.0049 0.0366 0.066
Echinococcus granulosus cysteine protease 0.004 0.0263 0.0466
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0697 0.1521
Plasmodium vivax aspartyl protease, putative 0.0037 0.0234 0.1338
Loa Loa (eye worm) hypothetical protein 0.0026 0.0111 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0012
Chlamydia trachomatis dihydrofolate reductase 0.0044 0.0307 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0046 0.0006
Onchocerca volvulus 0.007 0.0589 0.1109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0363 0.0832
Schistosoma mansoni hypothetical protein 0.0034 0.0193 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0046 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0046 0.0005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0215 0.0284
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0234 0.1338
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0012
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0697 0.4308
Plasmodium vivax vivapain-1 0.004 0.0263 0.1534
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0745 0.1146
Echinococcus multilocularis cathepsin l cysteine peptidase 0.007 0.0589 0.0643
Brugia malayi thymidylate synthase 0.0108 0.1007 0.2312
Onchocerca volvulus 0.007 0.0589 0.1109
Brugia malayi Papain family cysteine protease containing protein 0.002 0.004 0.0093
Giardia lamblia Cathepsin B precursor 0.0103 0.0948 0.1477
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0046 0.001
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0263 0.0603
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0046 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.007 0.0589 0.1351
Echinococcus granulosus cathepsin L cysteine protease 0.004 0.0263 0.0466
Schistosoma mansoni hypothetical protein 0.0334 0.3476 0.345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0263 0.1189
Leishmania major cathepsin L-like protease 0.0116 0.1095 0.7173
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0284 0.2933 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0475 0.0511
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0366 0.053
Onchocerca volvulus 0.0108 0.1007 0.1956
Schistosoma mansoni lamin 0.0027 0.0116 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0125 0.119 0.1155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.6188 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0152 0.1489 1
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0234 0.1338
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0215 0.0284
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0234 0.0407
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.004 0.0093
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.011
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0234 0.1338
Giardia lamblia Cathepsin B precursor 0.0103 0.0948 0.1477
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Onchocerca volvulus 0.0027 0.0116 0.0153
Echinococcus granulosus cathepsin b 0.0288 0.2975 0.6158
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0046 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0046 0.0005
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0353
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0697 0.1068
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0215 0.0284
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0263 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0046 0.0105
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0046 0.0011
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0189 0.1896 0.4353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0366 0.053
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0234 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0318 0.0279
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0452 0.0862
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0234 0.0538
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0475 0.0511
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0097 0.0391
Entamoeba histolytica cysteine proteinase, putative 0.007 0.0589 0.0892
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0215 0.0595
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0263 0.0223
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0366 0.0327
Trichomonas vaginalis chromobox protein, putative 0.0051 0.038 0.0553
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0108 0.1007 0.0971
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0234 0.0538
Brugia malayi ecdysteroid receptor 0.002 0.0046 0.0105
Echinococcus multilocularis dihydrofolate reductase 0.0044 0.0307 0.0313
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0046 0.0011
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0152 0.1489 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0255 0.0349
Loa Loa (eye worm) hypothetical protein 0.0049 0.0366 0.0755
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0046 0.0105
Plasmodium vivax plasmepsin V, putative 0.0037 0.0234 0.1338
Brugia malayi Cathepsin L-like cysteine proteinase 0.0049 0.0366 0.0841
Leishmania major cathepsin L-like protease 0.007 0.0589 0.3531
Echinococcus granulosus cathepsin b 0.0288 0.2975 0.6158
Brugia malayi cathepsin L-like precursor 0.0049 0.0366 0.0841
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Brugia malayi Muscleblind-like protein 0.0147 0.1435 0.3294
Loa Loa (eye worm) hypothetical protein 0.0121 0.1145 0.256
Loa Loa (eye worm) ShTK domain-containing protein 0.0189 0.1896 0.43
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1138 0.2544
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1581 0.1808
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0697 0.2236
Schistosoma mansoni tar DNA-binding protein 0.0125 0.119 0.1155
Echinococcus granulosus cathepsin l1 0.0049 0.0366 0.0684
Echinococcus multilocularis cysteine protease 0.007 0.0589 0.0643
Leishmania major cathepsin L-like protease 0.007 0.0589 0.3531
Echinococcus multilocularis thymidylate synthase 0.0108 0.1007 0.1135
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0103 0.0948 0.3093
Leishmania major cysteine peptidase A (CPA) 0.007 0.0589 0.3531
Schistosoma mansoni alpha glucosidase 0.0036 0.0215 0.0175
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0234 0.0449
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0363 0.0832
Trypanosoma cruzi cysteine peptidase, putative 0.0116 0.1095 0.3595
Onchocerca volvulus 0.0027 0.0116 0.0153
Schistosoma mansoni coup transcription factor 0.002 0.0046 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0472 0.4982 0.8038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0288 0.2975 0.2947
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0046 0.0105
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0263 0.0362
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 0.6188 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0318 0.0279
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0046 0.0011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0799 0.856 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0589 0.127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0215 0.0284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Echinococcus granulosus chromobox protein 1 0.0084 0.0745 0.1478
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0475 0.0437
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0046 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0234 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0388 0.0565
Trypanosoma brucei cysteine peptidase C (CPC) 0.0103 0.0948 0.6114
Entamoeba histolytica cysteine proteinase 2 0.004 0.0263 0.0362
Echinococcus multilocularis neuropeptide s receptor 0.0456 0.4807 0.5594
Echinococcus multilocularis chromobox protein 1 0.0084 0.0745 0.0827
Echinococcus granulosus thymidylate synthase 0.0108 0.1007 0.2028
Echinococcus granulosus FTZ F1 alpha 0.002 0.0046 0.0011
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0046 0.0011
Onchocerca volvulus 0.0298 0.3081 0.6153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0046 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0318 0.0326
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0012
Brugia malayi Pre-SET motif family protein 0.0415 0.4356 1
Schistosoma mansoni cathepsin F (C01 family) 0.007 0.0589 0.055
Brugia malayi hypothetical protein 0.0051 0.0388 0.089
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.007 0.0589 0.0892
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0116 0.0175
Onchocerca volvulus 0.007 0.0589 0.1109
Schistosoma mansoni thyroid hormone receptor 0.002 0.0046 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0318 0.0731
Plasmodium falciparum plasmepsin X 0.0037 0.0234 0.1338
Loa Loa (eye worm) hypothetical protein 0.0047 0.0341 0.0696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Brugia malayi Cathepsin L-like precursor 0.007 0.0589 0.1351
Onchocerca volvulus 0.0037 0.023 0.0383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1095 0.7173
Plasmodium vivax vivapain-2 0.007 0.0589 0.3784
Schistosoma mansoni nuclear hormone receptor 0.002 0.0046 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0046 0.0105
Schistosoma mansoni chromobox protein 0.0084 0.0745 0.0707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0475 0.0437
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0318 0.0583
Leishmania major cathepsin L-like protease 0.0116 0.1095 0.7173
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0046 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0048 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.0589 0.0892
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Loa Loa (eye worm) hypothetical protein 0.0049 0.0363 0.0747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0046 0.0012
Echinococcus multilocularis cathepsin b 0.0288 0.2975 0.3445
Onchocerca volvulus 0.007 0.0589 0.1109
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 0.6188 1
Toxoplasma gondii cathepsin B 0.0103 0.0948 0.6267
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0096 0.0873 0.2837
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1581 0.3629
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0234 0.1338
Trypanosoma cruzi cysteine peptidase, putative 0.0116 0.1095 0.3595
Brugia malayi Dihydrofolate reductase 0.0044 0.0307 0.0706
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Brugia malayi Cathepsin L-like precursor 0.007 0.0589 0.1351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0589 0.0892
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0294 0.1753
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0697 0.077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.6188 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0046 0.0012
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0215 0.0284
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0234 0.0449
Brugia malayi hypothetical protein 0.0025 0.0097 0.0223
Onchocerca volvulus 0.0189 0.1896 0.3755
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0475 0.0437
Onchocerca volvulus 0.0037 0.0234 0.0392
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0152 0.1489 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.038 0.0553
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0589 0.1868
Brugia malayi hypothetical protein 0.0037 0.0234 0.0538
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0046 0.0012
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0234 0.0195
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1419 0.1385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0263 0.1189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0318 0.0279
Onchocerca volvulus 0.0037 0.0234 0.0392
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.6188 1
Entamoeba histolytica cysteine protease, putative 0.004 0.0263 0.0362
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0175
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0215 0.1205
Brugia malayi Heterochromatin protein 1 0.0084 0.0745 0.171
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0288 0.2975 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (binding) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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