TDR Targets

Basic information

Technical information

TDR Targets ID: 1329701
Name: N-[3-[(4-bromophenyl)sulfamoyl]phenyl]-3-oxo- 4H-1,4-benzothiazine-6-carboxamide
MW: 518.403 | Formula: C21H16BrN3O4S2
H donors: 3 H acceptors: 4 LogP: 3.46 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: O=C1CSc2c(N1)cc(cc2)C(=O)Nc1cccc(c1)S(=O)(=O)Nc1ccc(cc1)Br
InChi: 1S/C21H16BrN3O4S2/c22-14-5-7-15(8-6-14)25-31(28,29)17-3-1-2-16(11-17)23-21(27)13-4-9-19-18(10-13)24-20(26)12-30-19/h1-11,25H,12H2,(H,23,27)(H,24,26)
InChiKey: PWCOSRZUOSVSEO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[3-[(4-bromophenyl)sulfamoyl]phenyl]-3-keto-4H-1,4-benzothiazine-6-carboxamide
MLS000392976
SMR000248124
T5231797

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Starlite/ChEMBL	No references
Homo sapiens	huntingtin	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase		No references
Homo sapiens	multiple endocrine neoplasia I		No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Leishmania major	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	hypothetical protein	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Leishmania mexicana	6-phospho-1-fructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Loa Loa (eye worm)	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Leishmania infantum	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus multilocularis	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Leishmania donovani	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Leishmania braziliensis	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium ulcerans	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma congolense	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0004	0.0005
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0069	0.1503
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.0261	0.0407
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0036	0.0035
Onchocerca volvulus		0.0073	0.0403	0.2189
Schistosoma mansoni	hypothetical protein	0.005	0.0261	0.0409
Echinococcus multilocularis	ferritin	0.0009	0.0015	0.0015
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.0403	0.5316
Schistosoma mansoni	cpg binding protein	0.0037	0.0184	0.0287
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.0403	0.0403
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.1688	0.1687
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0535	0.0835
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0176	0.1019
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0105	0.1345
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0105	0.1345
Brugia malayi	MH1 domain containing protein	0.0009	0.0018	0.0026
Brugia malayi	6-phosphofructokinase	0.0131	0.0755	0.118
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0535	0.0534
Brugia malayi	nuclear hormone receptor	0.0012	0.0036	0.0054
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0176	0.1019
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0067	0.0367	0.841
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.0436	0.0435
Brugia malayi	Latrophilin receptor protein 2	0.005	0.0261	0.0407
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0157	0.0908	0.1419
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.0403	0.063
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0062	0.0096
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0405	0.5339
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0007	0.0007	0.0006
Echinococcus multilocularis	neuropeptide receptor A26	0.0558	0.3337	0.3337
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0172	0.0267
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0405	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0007	0.0009
Brugia malayi	RNA binding protein	0.0063	0.0344	0.0537
Brugia malayi	MH2 domain containing protein	0.0244	0.1437	0.2246
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0344	0.0538
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.0261	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0069	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0036	0.0054
Brugia malayi	Pre-SET motif family protein	0.0252	0.1486	0.2322
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.0755	0.4442
Trichomonas vaginalis	helicase, putative	0.0008	0.0009	0.0032
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0225	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0405	0.5339
Schistosoma mansoni	hypothetical protein	0.0043	0.0219	0.0343
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0535	0.0534
Trichomonas vaginalis	ferritin, putative	0.0009	0.0015	0.0068
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0036	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0403	0.063
Brugia malayi	Pre-SET motif family protein	0.0037	0.0184	0.0287
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0062	0.0098
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.0755	0.118
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0105	0.1345
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0035	0.0176	0.3991
Brugia malayi	MH2 domain containing protein	0.0017	0.0062	0.0096
Echinococcus granulosus	GPCR family 2	0.005	0.0261	0.0407
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0105	0.1345
Toxoplasma gondii	hypothetical protein	0.0027	0.0125	0.2807
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0035	0.0176	0.2928
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0344	0.0343
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0004	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0229	0.133
Echinococcus granulosus	smad	0.0017	0.0062	0.0096
Schistosoma mansoni	hypothetical protein	0.0494	0.2948	0.461
Echinococcus multilocularis	protein dispatched 1	0.005	0.0267	0.0266
Echinococcus granulosus	mothers against decapentaplegic 6	0.0007	0.0007	0.0009
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0036	0.0054
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0036	0.0056
Brugia malayi	steroid hormone receptor	0.0012	0.0036	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0036	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0018	0.0026
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.0755	0.4442
Echinococcus multilocularis	GPCR, family 2	0.005	0.0261	0.026
Schistosoma mansoni	hypothetical protein	0.0043	0.0219	0.0343
Echinococcus granulosus	expressed protein	0.0009	0.0015	0.0023
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0403	0.5316
Schistosoma mansoni	hypothetical protein	0.0546	0.3263	0.5102
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0125	0.1482
Loa Loa (eye worm)	MH2 domain-containing protein	0.0007	0.0007	0.0009
Schistosoma mansoni	Smad4	0.0007	0.0007	0.0011
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0009	0.0032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0036	0.0054
Schistosoma mansoni	cpg binding protein	0.0037	0.0184	0.0287
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.0034	0.0052
Entamoeba histolytica	hypothetical protein	0.0043	0.0225	0.2936
Entamoeba histolytica	hypothetical protein	0.0043	0.0225	0.2936
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0036	0.0054
Schistosoma mansoni	hypothetical protein	0.0107	0.0609	0.0952
Brugia malayi	Niemann-Pick C1 protein precursor	0.0103	0.0584	0.0912
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0405	0.0634
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0022	0.0033
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.1064	0.6395	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0004	0.0005
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0105	0.1345
Loa Loa (eye worm)	transcription factor SMAD2	0.0244	0.1437	0.2246
Schistosoma mansoni	hypothetical protein	0.0043	0.0219	0.0343
Brugia malayi	beta-lactamase family protein	0.0073	0.0403	0.063
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0344	0.0537
Loa Loa (eye worm)	MH2 domain-containing protein	0.0244	0.1437	0.2246
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0105	0.1345
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0036	0.0054
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0009	0.0015	0.0042
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0009	0.0032
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0036	0.0054
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0062	0.0096
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0105	0.1345
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0036	0.0054
Schistosoma mansoni	ferritin	0.0009	0.0015	0.0024
Loa Loa (eye worm)	beta-lactamase	0.0073	0.0403	0.063
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0036	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0036	0.0054
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.0403	0.1438
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.0755	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0037	0.0184	0.0184
Schistosoma mansoni	cpg binding protein	0.0035	0.0172	0.0268
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0062	0.0098
Loa Loa (eye worm)	phosphofructokinase	0.0131	0.0755	0.118
Schistosoma mansoni	patched 1	0.0044	0.0229	0.0358
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0131	0.0755	0.2705
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0403	0.063
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0095	0.0535	0.0835
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0075	0.0415	0.0648
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0037	0.0184	0.0184
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0036	0.0056
Brugia malayi	hypothetical protein	0.0286	0.1688	0.2639
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0436	0.5747
Schistosoma mansoni	hypothetical protein	0.005	0.0261	0.0409
Mycobacterium leprae	Probable lipase LipE	0.0073	0.0403	0.5316
Onchocerca volvulus		0.0035	0.0172	0.0918
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0125	0.2807
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0535	0.0837
Onchocerca volvulus		0.0309	0.1829	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0036	0.0035
Entamoeba histolytica	hypothetical protein	0.0043	0.0225	0.2936
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0273	0.3574
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0036	0.0056
Brugia malayi	phosphofructokinase	0.0131	0.0755	0.118
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0062	0.0096
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0176	0.1019
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0157	0.0908	0.1419
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0035	0.0176	0.1019
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0344	0.0537
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0105	0.1345
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0344	0.0537
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0105	0.0364
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0036	0.0054
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0063	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0609	0.095
Brugia malayi	beta-lactamase family protein	0.0073	0.0403	0.063
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0036	0.0054
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.0261	0.026
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0436	0.068
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0036	0.0054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0036	0.0054
Echinococcus multilocularis	sodium channel protein	0.0052	0.0277	0.0276
Schistosoma mansoni	hypothetical protein	0.0043	0.0225	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0036	0.0054
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0436	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0147	0.0851	0.133
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0062	0.0098
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0436	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0035	0.0176	0.2928
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0009	0.0032
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0036	0.0035
Schistosoma mansoni	apoferritin-2	0.0009	0.0015	0.0024
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0012	0.0035	0.0053
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0344	0.0538
Echinococcus multilocularis	Niemann Pick C1 protein	0.0103	0.0584	0.0583
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.4999	0.4999
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0027	0.0125	0.1613
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0004	0.0005
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0036	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0405	0.5339
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0273	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0403	0.063
Schistosoma mansoni	hypothetical protein	0.0058	0.0314	0.0491
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0037	0.0184	0.4179
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0436	0.5747
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0105	0.0163
Mycobacterium ulcerans	bacterioferritin BfrA	0.0009	0.0015	0.0154
Echinococcus granulosus	expressed conserved protein	0.0097	0.0546	0.0853
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0535	0.0837
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.0436	0.068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0105	0.0163
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.0403	0.5316
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.0755	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0063	0.0213
Schistosoma mansoni	ferritin	0.0009	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0069	0.0106
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0004	0.0005
Echinococcus granulosus	neuropeptide receptor A26	0.0558	0.3337	0.5219
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0403	0.925
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0172	0.0267
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0036	0.0056
Brugia malayi	MH1 domain containing protein	0.0017	0.0062	0.0096
Onchocerca volvulus		0.0037	0.0184	0.0989
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.0755	0.4442
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0105	0.0594	0.0929
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0036	0.0056
Echinococcus multilocularis	smad	0.0017	0.0062	0.0062
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0036	0.0054
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0103	0.0584	0.7721
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0184	0.0287
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0036	0.0174
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.2948	0.2947
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0036	0.0054
Brugia malayi	MH1 domain containing protein	0.0017	0.0062	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0036	0.0054
Echinococcus granulosus	cpg binding protein	0.0037	0.0184	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0069	0.0106
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0036	0.0054
Brugia malayi	Smad1	0.0017	0.0062	0.0096
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0009	0.0032
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0176	0.1019
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0036	0.0054
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0007	0.0007	0.0006
Loa Loa (eye worm)	histone methyltransferase	0.0012	0.0035	0.0053
Brugia malayi	latrophilin 2 splice variant baaae	0.0107	0.0609	0.095
Brugia malayi	CHE-14 protein	0.0044	0.0229	0.0357
Plasmodium vivax	SET domain protein, putative	0.0037	0.0184	0.4179
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.1064	0.6395	0.6394
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0309	0.1829	0.2859
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0105	0.1345
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0069	0.1503
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.0755	1
Echinococcus multilocularis	protein patched	0.0044	0.0229	0.0228
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0436	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0063	0.0213
Schistosoma mansoni	ferritin	0.0009	0.0015	0.0024
Mycobacterium ulcerans	lipase LipD	0.0073	0.0403	0.5316
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0009	0.0015	0.0154
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0062	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0403	0.063
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0184	0.0288
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0052	0.0277	0.0432
Onchocerca volvulus		0.0073	0.0403	0.2189
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0036	0.0056
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.4999	0.7818
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0036	0.0054
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0405	0.0634
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0131	0.0755	1
Brugia malayi	Probable ClpP-like protease	0.0078	0.0436	0.068
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.0436	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0105	0.0163
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0009	0.0032
Schistosoma mansoni	coup transcription factor	0.0012	0.0036	0.0056
Echinococcus granulosus	geminin	0.0546	0.3263	0.5102
Brugia malayi	6-phosphofructokinase	0.0131	0.0755	0.118
Echinococcus multilocularis	sterol regulatory element binding protein	0.0044	0.0229	0.0228
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0157	0.0908	0.1419
Toxoplasma gondii	ABC1 family protein	0.0073	0.0403	0.925
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0131	0.0755	1
Loa Loa (eye worm)	nuclear factor I	0.0009	0.0018	0.0026
Echinococcus multilocularis	Smad4	0.0017	0.0062	0.0062
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0009	0.0015	0.0042
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0004	0.0005
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0105	0.1345
Onchocerca volvulus		0.0058	0.0314	0.1699
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0036	0.0054
Leishmania major	ATP-dependent phosphofructokinase	0.0131	0.0755	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0219	0.0343
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0004	0.0005
Mycobacterium ulcerans	beta-lactamase	0.0073	0.0403	0.5316
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0403	0.2361
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0052	0.0277	0.3634
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0225	0.035
Brugia malayi	MH2 domain containing protein	0.0007	0.0007	0.0009
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0403	0.5316
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.0403	0.5316
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.0403	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0856	0.1338
Schistosoma mansoni	serine/threonine protein kinase	0.1064	0.6395	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0131	0.0755	1
Schistosoma mansoni	hypothetical protein	0.005	0.0261	0.0409
Loa Loa (eye worm)	Smad1	0.0017	0.0062	0.0096
Echinococcus granulosus	ferritin	0.0009	0.0015	0.0023
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0125	0.2807
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0036	0.0054
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0405	0.1444
Entamoeba histolytica	hypothetical protein	0.0043	0.0225	0.2936
Schistosoma mansoni	ferritin	0.0009	0.0015	0.0024
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0036	0.0056
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0176	0.1019
Schistosoma mansoni	apoferritin-2	0.0009	0.0015	0.0024
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0172	0.0267
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.0755	0.1181
Echinococcus multilocularis	expressed conserved protein	0.0097	0.0546	0.0546
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.0436	0.5747
Plasmodium vivax	6-phosphofructokinase, putative	0.0035	0.0176	0.3991
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0403	0.0631
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0062	0.0062
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0436	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0535	0.0837
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.0436	0.0681
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.1064	0.6395	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0436	1
Brugia malayi	mothers against decapentaplegic homolog 3	0.0007	0.0007	0.0009
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0036	0.0054
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0036	0.0054
Schistosoma mansoni	hypothetical protein	0.0546	0.3263	0.5102
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0069	0.0106
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0035	0.0176	0.5
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0436	0.568
Echinococcus granulosus	sterol regulatory element binding protein	0.0044	0.0229	0.0357
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0105	0.1345
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0007	0.0007	0.0016
Echinococcus granulosus	Niemann Pick C1 protein	0.0103	0.0584	0.0912
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0036	0.0174
Brugia malayi	MH2 domain containing protein	0.0017	0.0062	0.0096
Brugia malayi	beta-lactamase	0.0073	0.0403	0.063
Echinococcus granulosus	6 phosphofructokinase	0.0131	0.0755	0.118
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0036	0.0054
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0252	0.1486	0.2322
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.0755	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0273	0.0272
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0403	0.5316
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0036	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0403	0.063
Trichomonas vaginalis	set domain proteins, putative	0.0287	0.1696	1
Echinococcus multilocularis	geminin	0.0546	0.3263	0.3262
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0004	0.0006
Onchocerca volvulus		0.0073	0.0403	0.2189
Onchocerca volvulus		0.0287	0.1696	0.9269
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0036	0.0054
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0035	0.0176	0.2294
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0036	0.0035
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0001	0.0001
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0436	1
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0036	0.0056
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0467	0.2782	1
Schistosoma mansoni	Smad4	0.0017	0.0062	0.0098
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0009	0.0032
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0012	0.0035	0.0034
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0069	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0286	0.1688	0.2639
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0036	0.0054
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0044	0.0229	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0584	0.0912
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0036	0.0035
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0063	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0229	0.0357
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0036	0.0056
Schistosoma mansoni	ferritin light chain	0.0009	0.0015	0.0024
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0062	0.0096
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0035	0.0176	0.3991
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0036	0.0054
Schistosoma mansoni	smad	0.0017	0.0062	0.0098
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0403	0.1438
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0405	0.5339
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.0403	0.1438
Onchocerca volvulus	Huntingtin homolog	0.0148	0.0856	0.467
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.001	0.0022	0.0021
Echinococcus multilocularis	Niemann Pick C1 protein	0.0147	0.0851	0.085
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0036	0.0035
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0403	0.1438
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.0403	0.5316
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0036	0.0054
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0176	0.1019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0535	0.0835
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0095	0.0535	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0069	0.0106
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0314	0.0491
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0403	0.2361
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0036	0.0054
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0022	0.0021
Echinococcus granulosus	histone lysine methyltransferase setb	0.0037	0.0184	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0036	0.0054
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0105	0.1345
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0403	0.2361
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Mycobacterium ulcerans	bacterioferritin BfrB	0.0009	0.0015	0.0154
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0344	0.0537
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0105	0.1345
Echinococcus multilocularis	cpg binding protein	0.0037	0.0184	0.0183
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0036	0.0054
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0036	0.0054
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0004	0.0005
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0036	0.0056
Brugia malayi	hypothetical protein	0.0309	0.1829	0.2859
Echinococcus granulosus	Smad4	0.0017	0.0062	0.0096
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0105	0.0163
Loa Loa (eye worm)	hypothetical protein	0.005	0.0261	0.0407
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0035	0.0176	0.3991
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0004	0.0005
Plasmodium vivax	6-phosphofructokinase, putative	0.0035	0.0176	0.3991
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0004	0.0005
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0184	0.0288
Schistosoma mansoni	hypothetical protein	0.005	0.0261	0.0409
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.0261	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0004	0.0005
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0036	0.0035
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.0261	0.026
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0009	0.0032
Echinococcus granulosus	sodium channel protein	0.0052	0.0277	0.0432
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0344	0.0537
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Brugia malayi	hypothetical protein	0.0043	0.0225	0.035
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0105	0.0163
Loa Loa (eye worm)	MH1 domain-containing protein	0.0007	0.0007	0.0009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0036	0.0054
Onchocerca volvulus		0.0024	0.0105	0.0554
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0036	0.0054
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0314	0.049
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.0755	0.4442
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0036	0.0054
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.0403	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0004	0.0005
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.0755	0.1181
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0908	0.1419
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.0403	0.1438
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0069	0.0234
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0001	0.0001
Brugia malayi	MH1 domain containing protein	0.0009	0.0018	0.0026
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.0755	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0403	0.2361
Echinococcus multilocularis	6 phosphofructokinase	0.0131	0.0755	0.0755
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0273	0.0425
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0036	0.0035
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0009	0.0032
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0036	0.0174
Schistosoma mansoni	ferritin light chain	0.0009	0.0015	0.0024
Schistosoma mansoni	Smad4	0.0007	0.0007	0.0011
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.0403	0.1438
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0405	0.9291
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0403	0.1438
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.0261	0.0407
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0344	0.0538
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.0403	0.1438
Onchocerca volvulus	Huntingtin homolog	0.0148	0.0856	0.467
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.0403	0.063
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.2948	0.4609
Brugia malayi	hypothetical protein	0.0148	0.0856	0.1338
Echinococcus multilocularis	expressed protein	0.0009	0.0015	0.0015
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0105	0.0163
Leishmania major	hypothetical protein, conserved	0.0073	0.0403	0.5316
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0105	0.1345
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.4999	0.7818
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0036	0.0056
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0036	0.0056
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0036	0.0054
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0036	0.0054
Onchocerca volvulus		0.0012	0.0036	0.0174
Schistosoma mansoni	smad	0.0007	0.0007	0.0011
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0273	0.0967
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0036	0.0054
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0403	0.2361
Trichomonas vaginalis	esterase, putative	0.0073	0.0403	0.2361
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.0755	0.118
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0403	0.063
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0225	0.0351
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0004	0.0003
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.0403	0.063
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0405	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0289	0.0451
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0403	0.0631
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Toxoplasma gondii	6-phosphofructokinase	0.0035	0.0176	0.3991
Echinococcus granulosus	mixed lineage leukemia protein mll	0.001	0.0022	0.0033
Echinococcus multilocularis	neuropeptide s receptor	0.0558	0.3337	0.3337
Brugia malayi	TAR-binding protein	0.0063	0.0344	0.0537
Toxoplasma gondii	phosphofructokinase PFKII	0.0035	0.0176	0.3991
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.1688	0.2639
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0035	0.0176	0.2173
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0344	0.0538
Brugia malayi	map kinase activated protein kinase protein 2	0.1064	0.6395	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0105	0.1345
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0009	0.0032
Echinococcus granulosus	neuropeptide s receptor	0.0558	0.3337	0.5219
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0184	0.0288
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0105	0.1345
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.001	0.0022	0.0034
Brugia malayi	ecdysteroid receptor	0.0012	0.0036	0.0054
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0105	0.0364
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0037	0.0184	0.0288
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0344	0.0538
Echinococcus granulosus	mothers against decapentaplegic 2	0.0007	0.0007	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0856	0.1338
Echinococcus granulosus	Protein patched homolog 1	0.0044	0.0229	0.0357

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 2.2387 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	10.691 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.99 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	21.1923 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	37.933 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1470450

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1329701