Detailed information for compound 1334126
Basic information
Technical information
- Name: Unnamed compound
- MW: 440.537 | Formula: C27H28N4O2
-
H donors: 0
H acceptors: 0
LogP: 4.38
Rotable bonds: 6
Rule of 5 violations (Lipinski): 1 - SMILES: COc1ccc(cc1)C1c2c(ncn(c2=N)CCCN(C)C)Oc2c1ccc1c2cccc1
- InChi: 1S/C27H28N4O2/c1-30(2)15-6-16-31-17-29-27-24(26(31)28)23(19-9-12-20(32-3)13-10-19)22-14-11-18-7-4-5-8-21(18)25(22)33-27/h4-5,7-14,17,23,28H,6,15-16H2,1-3H3
- InChiKey: TVZWPPUCJIAREL-UHFFFAOYSA-N
Network
Hover on a compound node to display the structore
Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Plasmodium falciparum | lysine--tRNA ligase | Starlite/ChEMBL | No references |
| Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
| Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
| Plasmodium falciparum | hexose transporter | Starlite/ChEMBL | No references |
| Plasmodium falciparum (isolate 3D7) | Proline--tRNA ligase | Starlite/ChEMBL | No references |
| Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
| Plasmodium falciparum | calcium-dependent protein kinase 1 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | protein kinase 6 | Starlite/ChEMBL | No references |
| Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
| Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
| Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
| Homo sapiens | RAD52 homolog (S. cerevisiae) | Starlite/ChEMBL | No references |
| Plasmodium falciparum (isolate 3D7) | Calcium-dependent protein kinase 4 | Starlite/ChEMBL | No references |
| Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
| Plasmodium falciparum | protein kinase 7 | Starlite/ChEMBL | No references |
| Leishmania mexicana | glucose transporter, lmgt2 | Starlite/ChEMBL | No references |
| Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
| Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
| Plasmodium falciparum | mitogen-activated protein kinase 2 | Starlite/ChEMBL | No references |
| Homo sapiens | multiple endocrine neoplasia I | No references | |
| Homo sapiens | solute carrier family 2 (facilitated glucose transporter), member 1 | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0007 | 0.0025 | 0.0028 |
| Leishmania major | glucose transporter, lmgt1 | 0.0039 | 0.063 | 0.868 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0012 | 0.0116 | 0.1483 |
| Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.0119 | 0.2146 | 0.2722 |
| Plasmodium vivax | proline--tRNA ligase, putative | 0.0044 | 0.0724 | 0.0701 |
| Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.0423 | 1 |
| Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.0122 | 0.0365 |
| Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.0012 | 0.0116 | 0.2564 |
| Trypanosoma cruzi | lysyl-tRNA synthetase, putative | 0.0028 | 0.0423 | 0.5783 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2273 | 0.2467 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0122 | 0.0132 |
| Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0007 | 0.0025 | 0.0218 |
| Leishmania major | lysyl-tRNA synthetase, putative | 0.0028 | 0.0423 | 0.5783 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.0226 | 0.0246 |
| Brugia malayi | Bifunctional aminoacyl-tRNA synthetase | 0.0038 | 0.0606 | 0.1817 |
| Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0251 | 0.0272 |
| Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1335 | 0.1449 |
| Schistosoma mansoni | hypothetical protein | 0.0494 | 0.9213 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0116 | 0.0347 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0122 | 0.0365 |
| Brugia malayi | Cam kinase protein 1 | 0.0039 | 0.0621 | 0.1861 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0122 | 0.0365 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.004 | 0.0132 |
| Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0018 | 0.0226 | 0.0678 |
| Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0025 | 0.0076 |
| Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0583 | 0.0633 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0094 | 0.0102 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Plasmodium vivax | sugar transporter, putative | 0.0018 | 0.0226 | 0.0201 |
| Mycobacterium ulcerans | prolyl-tRNA synthetase | 0.0013 | 0.0144 | 0.3243 |
| Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.0013 | 0.0014 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0039 | 0.0621 | 0.0597 |
| Brugia malayi | topoisomerase | 0.0012 | 0.0116 | 0.0347 |
| Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0122 | 0.0132 |
| Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0122 | 0.0365 |
| Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0.0251 | 0.3382 |
| Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0226 | 0.303 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0621 | 0.0674 |
| Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0012 | 0.0116 | 0.0468 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0251 | 0.0273 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0122 | 0.0365 |
| Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0122 | 0.0365 |
| Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0013 | 0.0039 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0122 | 0.0365 |
| Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0251 | 0.0272 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0621 | 0.0674 |
| Loa Loa (eye worm) | sugar transporter | 0.0018 | 0.0226 | 0.0678 |
| Giardia lamblia | DNA repair protein RAD52 | 0.042 | 0.7814 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3753 | 0.4074 |
| Mycobacterium leprae | Possible lysyl-tRNA synthetase 2 LysX | 0.0028 | 0.0423 | 0.6932 |
| Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1335 | 0.1449 |
| Echinococcus granulosus | lysyl tRNA synthetase | 0.0028 | 0.0423 | 0.0459 |
| Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0251 | 0.0272 |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0273 |
| Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0583 | 0.0633 |
| Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0122 | 0.0132 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0226 | 0.0678 |
| Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0122 | 0.0365 |
| Trichomonas vaginalis | prolyl-tRNA synthetase, putative | 0.0038 | 0.0606 | 0.2634 |
| Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0122 | 0.0132 |
| Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0668 | 0.2003 |
| Toxoplasma gondii | lysine-tRNA ligase | 0.0028 | 0.0423 | 0.0625 |
| Chlamydia trachomatis | DNA ligase | 0.0012 | 0.0116 | 0.2273 |
| Trypanosoma brucei | sugar transporter, putative | 0.0018 | 0.0226 | 0.303 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0039 | 0.0621 | 0.0925 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0039 | 0.0621 | 0.0597 |
| Mycobacterium ulcerans | fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT | 0.0018 | 0.0226 | 0.5239 |
| Mycobacterium leprae | Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) | 0.0024 | 0.0343 | 0.5587 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0251 | 0.0272 |
| Brugia malayi | lysyl-tRNA synthetase | 0.0028 | 0.0423 | 0.1268 |
| Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0122 | 0.0132 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0122 | 0.0365 |
| Trichomonas vaginalis | replication factor C large subunit, putative | 0.0012 | 0.0116 | 0.0468 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0116 | 0.0468 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0122 | 0.0132 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0012 | 0.0116 | 0.016 |
| Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.0423 | 0.0459 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0226 | 0.0246 |
| Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0606 | 0.1817 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0122 | 0.0365 |
| Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0091 | 0.0274 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0621 | 0.0674 |
| Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0122 | 0.0365 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Brugia malayi | Sugar transporter family protein | 0.0018 | 0.0226 | 0.0678 |
| Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3335 | 1 |
| Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0251 | 0.3382 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.0007 | 0.0025 | 0.0218 |
| Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0013 | 0.0039 |
| Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3753 | 0.4074 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0122 | 0.0132 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.004 | 0.0132 |
| Plasmodium vivax | CDK-related protein kinase 6, putative | 0.0536 | 1 | 1 |
| Plasmodium vivax | lysine--tRNA ligase, putative | 0.0028 | 0.0423 | 0.0399 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0122 | 0.0365 |
| Plasmodium falciparum | hexose transporter | 0.0126 | 0.2273 | 0.2253 |
| Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0273 |
| Chlamydia trachomatis | proline--tRNA ligase | 0.0013 | 0.0144 | 0.2978 |
| Trichomonas vaginalis | sugar transport protein, putative | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus granulosus | nibrin | 0.0012 | 0.0116 | 0.0126 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.0226 | 0.0246 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0122 | 0.0365 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0122 | 0.0365 |
| Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0013 | 0.0039 |
| Leishmania major | glucose transporter, lmgt2 | 0.0039 | 0.063 | 0.868 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.063 | 0.274 |
| Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0013 | 0.0039 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0621 | 0.0674 |
| Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0039 | 0.0621 | 0.0597 |
| Onchocerca volvulus | 0.0012 | 0.0116 | 0.0347 | |
| Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0122 | 0.0132 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0122 | 0.0365 |
| Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0122 | 0.0132 |
| Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0251 | 0.0752 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0016 | 0.0185 | 0.0554 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Schistosoma mansoni | chromosome transmission fidelity factor | 0.0012 | 0.0116 | 0.0126 |
| Echinococcus multilocularis | nibrin | 0.0012 | 0.0116 | 0.0126 |
| Trypanosoma brucei | glucose transporter 2A | 0.0039 | 0.063 | 0.868 |
| Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.0621 | 0.0764 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2273 | 0.2467 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0018 | 0.0226 | 0.303 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2273 | 0.2467 |
| Mycobacterium tuberculosis | Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) | 0.0018 | 0.0226 | 0.6499 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0025 | 0.0357 | 0.1536 |
| Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0012 | 0.0116 | 0.0116 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0122 | 0.0365 |
| Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0546 | 0.1637 |
| Trypanosoma cruzi | glucose transporter, putative | 0.0018 | 0.0226 | 0.303 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0226 | 0.0678 |
| Plasmodium vivax | mitogen-activated protein kinase 2, putative | 0.0204 | 0.374 | 0.3724 |
| Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0044 | 0.0724 | 1 |
| Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0122 | 0.0365 |
| Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0122 | 0.0365 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0013 | 0.0039 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Trypanosoma brucei | bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0724 | 1 |
| Brugia malayi | DKFZp564C0469 protein | 0.0012 | 0.0116 | 0.0347 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0116 | 0.0347 |
| Entamoeba histolytica | prolyl-tRNA synthetase, putative | 0.0038 | 0.0606 | 0.0745 |
| Toxoplasma gondii | cell-cycle-associated protein kinase MAPK, putative | 0.0204 | 0.374 | 0.5643 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0122 | 0.0132 |
| Schistosoma mansoni | hypothetical protein | 0.0126 | 0.2273 | 0.2467 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0116 | 0.0468 |
| Toxoplasma gondii | ATPase, AAA family protein | 0.0012 | 0.0116 | 0.016 |
| Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0251 | 0.7255 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.0226 | 0.0246 |
| Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.004 | 0.0132 |
| Plasmodium falciparum | mitogen-activated protein kinase 2 | 0.0204 | 0.374 | 0.3724 |
| Brugia malayi | hypothetical protein | 0.0012 | 0.0116 | 0.0347 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0116 | 0.0347 |
| Toxoplasma gondii | sugar transporter ST1 | 0.0018 | 0.0226 | 0.0327 |
| Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0122 | 0.0365 |
| Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0122 | 0.0132 |
| Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0.0251 | 0.3382 |
| Giardia lamblia | Hexose transporter | 0.0018 | 0.0226 | 0.0258 |
| Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.0122 | 0.0132 |
| Loa Loa (eye worm) | sugar transporter | 0.0126 | 0.2273 | 0.6816 |
| Echinococcus granulosus | geminin | 0.0205 | 0.3753 | 0.4074 |
| Brugia malayi | Sugar transporter family protein | 0.0018 | 0.0226 | 0.0678 |
| Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1335 | 0.4003 |
| Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0724 | 1 |
| Toxoplasma gondii | transporter, major facilitator family protein | 0.0018 | 0.0226 | 0.0327 |
| Brugia malayi | hypothetical protein | 0.0006 | 0.0013 | 0.0039 |
| Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.0122 | 0.0365 |
| Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.004 | 0.0132 |
| Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus multilocularis | glycyl tRNA synthetase | 0.0007 | 0.0025 | 0.0028 |
| Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1335 | 0.1449 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0122 | 0.0365 |
| Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0039 | 0.0621 | 0.0597 |
| Leishmania major | threonyl-tRNA synthetase, putative | 0.0007 | 0.0025 | 0.0218 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus multilocularis | calcium dependent protein kinase | 0.0036 | 0.0576 | 0.0625 |
| Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0583 | 0.0633 |
| Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0251 | 0.3382 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0116 | 0.0468 |
| Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0122 | 0.0132 |
| Leishmania major | myo-inositol/proton symporter (MIT) | 0.0018 | 0.0226 | 0.303 |
| Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0039 | 0.0621 | 0.0597 |
| Schistosoma mansoni | DNA ligase IV | 0.0012 | 0.0116 | 0.0126 |
| Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0116 | 0.0116 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0621 | 0.0674 |
| Brugia malayi | threonyl-tRNA synthetase, cytoplasmic | 0.0007 | 0.0025 | 0.0076 |
| Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.0621 | 0.0764 |
| Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0606 | 0.1817 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0039 | 0.0621 | 0.0674 |
| Mycobacterium leprae | Probable prolyl tRNA synthetase ProS | 0.0038 | 0.0606 | 1 |
| Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0012 | 0.0116 | 0.4499 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Giardia lamblia | Prolyl-tRNA synthetase | 0.0038 | 0.0606 | 0.0745 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0116 | 0.0468 |
| Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.0226 | 0.0246 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trypanosoma cruzi | sugar transporter, putative | 0.0018 | 0.0226 | 0.303 |
| Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0251 | 0.0272 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0122 | 0.0365 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0012 | 0.0116 | 0.1483 |
| Brugia malayi | probable proline-trna synthetase - fission yeast, putative | 0.0007 | 0.0025 | 0.0076 |
| Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.128 | 0.1389 |
| Schistosoma mansoni | nuclear transcription factor X-box binding 1 (nfx1) | 0.0018 | 0.0226 | 0.0246 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.063 | 0.274 |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0273 |
| Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1335 | 0.1449 |
| Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0038 | 0.0606 | 0.0658 |
| Onchocerca volvulus | 0.0035 | 0.0546 | 0.1637 | |
| Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0094 | 0.0102 |
| Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0251 | 0.0272 |
| Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0366 |
| Toxoplasma gondii | prolyl-tRNA synthetase (ProRS) | 0.0044 | 0.0724 | 0.1081 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0122 | 0.0365 |
| Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0122 | 0.0365 |
| Echinococcus multilocularis | Sugar transporter ERD6 protein | 0.0018 | 0.0226 | 0.0246 |
| Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.004 | 0.0132 |
| Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0251 | 0.3382 |
| Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase ID | 0.0039 | 0.0621 | 0.1861 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0226 | 0.0956 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Mycobacterium ulcerans | sugar-transport integral membrane protein SugI | 0.0018 | 0.0226 | 0.5239 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Echinococcus granulosus | replication factor c subunit 1 | 0.0012 | 0.0116 | 0.0126 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trypanosoma brucei | glucose transporter 1E | 0.0039 | 0.063 | 0.868 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0116 | 0.0347 |
| Echinococcus multilocularis | glutamyl tRNA synthetase cytoplasmic | 0.0038 | 0.0606 | 0.0658 |
| Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0007 | 0.0025 | 0.0377 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.004 | 0.0132 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2273 | 0.2467 |
| Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0006 | 0.0013 | 0.0014 |
| Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0251 | 0.0272 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0006 | 0.0013 | 0.0039 |
| Brugia malayi | Pax transcription activation domain interacting protein | 0.0012 | 0.0116 | 0.0347 |
| Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0039 | 0.0621 | 0.0597 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0039 | 0.0621 | 0.0925 |
| Echinococcus granulosus | General substrate transporter | 0.0108 | 0.1938 | 0.2104 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus granulosus | calcium dependent protein kinase | 0.0036 | 0.0576 | 0.0625 |
| Onchocerca volvulus | 0.0182 | 0.3335 | 1 | |
| Mycobacterium ulcerans | sugar transporter | 0.0018 | 0.0226 | 0.5239 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0122 | 0.0365 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0366 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Giardia lamblia | Replication factor C, subunit 1 | 0.0012 | 0.0116 | 0.0116 |
| Brugia malayi | nuclear receptor RXR | 0.0006 | 0.0013 | 0.0039 |
| Echinococcus multilocularis | General substrate transporter | 0.0108 | 0.1938 | 0.2104 |
| Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0122 | 0.0365 |
| Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.9213 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0122 | 0.0365 |
| Schistosoma mansoni | glycyl-tRNA synthetase | 0.0007 | 0.0025 | 0.0028 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0006 | 0.0013 | 0.0014 |
| Trichomonas vaginalis | helicase, putative | 0.0008 | 0.004 | 0.0132 |
| Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0423 | 0.0511 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0012 | 0.0116 | 0.1483 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0472 | 0.1415 |
| Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0122 | 0.0132 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0226 | 0.0956 |
| Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2273 | 0.2467 |
| Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0583 | 0.0633 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Leishmania major | protein kinase, putative | 0.0039 | 0.0621 | 0.855 |
| Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0126 | 0.2273 | 0.2467 |
| Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0754 |
| Brugia malayi | Sugar transporter family protein | 0.0126 | 0.2273 | 0.6816 |
| Schistosoma mansoni | glucose transporter | 0.0018 | 0.0226 | 0.0246 |
| Brugia malayi | glycyl-tRNA synthetase | 0.0007 | 0.0025 | 0.0076 |
| Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0546 | 0.1637 |
| Brugia malayi | TAR-binding protein | 0.0076 | 0.1335 | 0.4003 |
| Mycobacterium ulcerans | integral membrane transport protein | 0.0018 | 0.0226 | 0.5239 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1027 | 0.3081 |
| Treponema pallidum | prolyl-tRNA synthetase | 0.0013 | 0.0144 | 1 |
| Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0273 |
| Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0039 | 0.0621 | 0.0597 |
| Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0122 | 0.0132 |
| Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0122 | 0.0365 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0122 | 0.0365 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.063 | 0.274 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0621 | 0.0674 |
| Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0006 | 0.0013 | 0.0014 |
| Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0122 | 0.0365 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0116 | 0.0468 |
| Loa Loa (eye worm) | CAMK/CAMK2 protein kinase | 0.0039 | 0.0621 | 0.1861 |
| Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0273 |
| Onchocerca volvulus | 0.0012 | 0.0122 | 0.0365 | |
| Toxoplasma gondii | glycyl-tRNA synthetase | 0.0007 | 0.0025 | 0.0024 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0039 | 0.0621 | 0.0925 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.063 | 0.274 |
| Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0012 | 0.0116 | 0.0468 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0621 | 0.0674 |
| Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0122 | 0.0365 |
| Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0251 | 0.0272 |
| Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0039 | 0.0621 | 0.0597 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2273 | 0.2467 |
| Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0038 | 0.0606 | 0.1817 |
| Plasmodium vivax | hexose transporter | 0.0126 | 0.2273 | 0.2253 |
| Trypanosoma cruzi | FHA domain containing protein, putative | 0.0012 | 0.0116 | 0.1483 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus multilocularis | replication factor c subunit 1 | 0.0012 | 0.0116 | 0.0126 |
| Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0.0251 | 0.0227 |
| Giardia lamblia | Lysyl-tRNA synthetase | 0.0028 | 0.0423 | 0.0511 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.042 | 0.7814 | 1 |
| Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0013 | 0.0039 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0122 | 0.0365 |
| Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0226 | 0.0246 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.0423 | 1 |
| Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0122 | 0.0132 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Plasmodium vivax | replication factor C subunit 1, putative | 0.0012 | 0.0116 | 0.0091 |
| Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1027 | 0.3081 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0621 | 0.0674 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0226 | 0.0678 |
| Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0013 | 0.0039 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.004 | 0.0132 |
| Trichomonas vaginalis | myo-inositol transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0273 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2273 | 0.2467 |
| Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0054 | 0.0059 |
| Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1027 | 0.3081 |
| Schistosoma mansoni | topbp1 | 0.0012 | 0.0116 | 0.0126 |
| Echinococcus multilocularis | geminin | 0.0205 | 0.3753 | 0.4074 |
| Brugia malayi | steroid hormone receptor | 0.0012 | 0.0122 | 0.0365 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0251 | 0.0272 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0116 | 0.0347 |
| Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0094 | 0.0281 |
| Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.004 | 0.0132 |
| Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0621 | 0.1861 |
| Brugia malayi | major facilitator superfamily protein | 0.0018 | 0.0226 | 0.0678 |
| Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0122 | 0.0365 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0126 | 0.2273 | 1 |
| Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0044 | 0.0724 | 1 |
| Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0012 | 0.0116 | 0.0347 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.063 | 0.274 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0621 | 0.0674 |
| Trypanosoma brucei | calcium/calmodulin-dependent protein kinase, putative | 0.0039 | 0.0621 | 0.855 |
| Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0122 | 0.0132 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0226 | 0.0956 |
| Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0039 | 0.0621 | 0.0597 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2273 | 0.2467 |
| Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0668 | 0.0725 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0226 | 0.0246 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0122 | 0.0132 |
| Echinococcus granulosus | glutamyl tRNA synthetase cytoplasmic | 0.0038 | 0.0606 | 0.0658 |
| Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0122 | 0.0365 |
| Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0126 | 0.2273 | 0.3424 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0012 | 0.0116 | 0.0468 |
| Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0251 | 0.0752 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Trichomonas vaginalis | glucose transporter, putative | 0.0039 | 0.063 | 0.274 |
| Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1335 | 0.1449 |
| Trypanosoma brucei | lysyl-tRNA synthetase, putative | 0.0028 | 0.0423 | 0.5783 |
| Echinococcus granulosus | synaptic vesicle 2 protein | 0.0018 | 0.0226 | 0.0246 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0226 | 0.0246 |
| Echinococcus granulosus | Sugar transporter ERD6 protein | 0.0018 | 0.0226 | 0.0246 |
| Mycobacterium ulcerans | glycyl-tRNA synthetase | 0.0007 | 0.0025 | 0.0377 |
| Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0122 | 0.0132 |
| Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0012 | 0.0116 | 0.1483 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1335 | 0.1449 |
| Plasmodium falciparum | protein kinase 7 | 0.0357 | 0.6621 | 0.6612 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus multilocularis | lysyl tRNA synthetase | 0.0028 | 0.0423 | 0.0459 |
| Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0007 | 0.0025 | 0.0028 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0007 | 0.0025 | 0.0076 |
| Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0039 | 0.063 | 0.868 |
| Treponema pallidum | DNA ligase (lig) | 0.0012 | 0.0116 | 0.7633 |
| Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0122 | 0.0132 |
| Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0039 | 0.0621 | 0.1861 |
| Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0028 | 0.0423 | 0.1826 |
| Brugia malayi | hypothetical protein | 0.0012 | 0.0116 | 0.0347 |
| Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0668 | 0.2003 |
| Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0251 | 0.0752 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0054 | 0.0059 |
| Schistosoma mansoni | topbp1 | 0.0012 | 0.0116 | 0.0126 |
| Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0007 | 0.0025 | 0.0076 |
| Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0038 | 0.0606 | 0.0658 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0226 | 0.0246 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0621 | 0.0674 |
| Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0054 | 0.0059 |
| Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0724 | 1 |
| Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.0012 | 0.0116 | 0.1778 |
| Brugia malayi | RNA binding protein | 0.0076 | 0.1335 | 0.4003 |
| Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.1131 | 0.1697 |
| Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1335 | 0.4003 |
| Toxoplasma gondii | protein kinase, putative | 0.0357 | 0.6621 | 1 |
| Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.9213 | 1 |
| Toxoplasma gondii | sugar transporter ST2 | 0.0018 | 0.0226 | 0.0327 |
| Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0754 |
| Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0.0251 | 0.0227 |
| Entamoeba histolytica | hypothetical protein | 0.0119 | 0.2146 | 0.2722 |
| Mycobacterium tuberculosis | Probable conserved integral membrane transport protein | 0.0018 | 0.0226 | 0.6499 |
| Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0122 | 0.0132 |
| Trypanosoma brucei | myo-inositol/proton symporter (MIT) | 0.0018 | 0.0226 | 0.303 |
| Onchocerca volvulus | Putative transporter | 0.0018 | 0.0226 | 0.0678 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0039 | 0.063 | 0.274 |
| Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0251 | 0.0272 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Brugia malayi | hypothetical protein | 0.0006 | 0.0013 | 0.0039 |
| Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0007 | 0.0025 | 0.0262 |
| Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0423 | 0.1268 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0546 | 0.0592 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0226 | 0.0246 |
| Plasmodium falciparum | proline--tRNA ligase | 0.0044 | 0.0724 | 0.0701 |
| Plasmodium falciparum | major facilitator superfamily domain-containing protein, putative | 0.0018 | 0.0226 | 0.0201 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0116 | 0.0347 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0621 | 0.0674 |
| Brugia malayi | hypothetical protein | 0.0182 | 0.3335 | 1 |
| Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0054 | 0.0059 |
| Plasmodium falciparum | lysine--tRNA ligase | 0.0028 | 0.0423 | 0.0399 |
| Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0251 | 0.0752 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.004 | 0.0132 |
| Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0007 | 0.0025 | 0.0024 |
| Trypanosoma cruzi | hexose transporter | 0.0039 | 0.063 | 0.868 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0122 | 0.0365 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0226 | 0.0678 |
| Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0007 | 0.0025 | 0.0218 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0021 | 0.0295 | 0.3994 |
| Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0007 | 0.0025 | 0.0069 |
| Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.0122 | 0.0365 |
| Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0018 | 0.0226 | 0.0678 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0.0226 | 0.0956 |
| Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0012 | 0.0116 | 0.0468 |
| Giardia lamblia | Sugar-proton symporter | 0.0018 | 0.0226 | 0.0258 |
| Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0122 | 0.0365 |
| Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1335 | 0.4003 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0054 | 0.0059 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Mycobacterium tuberculosis | Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) | 0.0024 | 0.0343 | 1 |
| Echinococcus granulosus | glycyl tRNA synthetase | 0.0007 | 0.0025 | 0.0028 |
| Trypanosoma brucei | glycyl-tRNA synthetase, putative | 0.0007 | 0.0025 | 0.0218 |
| Onchocerca volvulus | 0.0018 | 0.0226 | 0.0678 | |
| Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1027 | 0.3081 |
| Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0122 | 0.0365 |
| Wolbachia endosymbiont of Brugia malayi | major facilitator superfamily permease | 0.0018 | 0.0226 | 1 |
| Mycobacterium tuberculosis | Lysyl-tRNA synthetase 2 LysX | 0.0024 | 0.0343 | 1 |
| Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1335 | 0.4003 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2273 | 0.2467 |
| Plasmodium falciparum | replication factor C subunit 1, putative | 0.0012 | 0.0116 | 0.0091 |
| Leishmania major | glucose transporter, lmgt3 | 0.0039 | 0.063 | 0.868 |
| Brugia malayi | major facilitator superfamily protein | 0.0018 | 0.0226 | 0.0678 |
| Echinococcus multilocularis | synaptic vesicle 2 protein | 0.0018 | 0.0226 | 0.0246 |
| Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.0423 | 0.0459 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0226 | 0.0246 |
| Chlamydia trachomatis | lysine--tRNA ligase | 0.0028 | 0.0423 | 1 |
| Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0122 | 0.0132 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.0621 | 0.2699 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0251 | 0.0754 |
| Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1335 | 0.1449 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0018 | 0.0226 | 0.0956 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2273 | 0.2467 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0226 | 0.0246 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0007 | 0.0025 | 0.0468 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.063 | 0.868 |
| Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0122 | 0.0132 |
| Toxoplasma gondii | sugar transporter ST3 | 0.0018 | 0.0226 | 0.0327 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| AC50 (functional) | = 2.33 uM | PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| EC50 (functional) | = 1230 nM | MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). | ChEMBL. | No reference |
| EC50 (functional) | = 2.86 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1554, AID1674] | ChEMBL. | No reference |
| EC50 (functional) | = 4.182 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] | ChEMBL. | No reference |
| EC50 (functional) | = 5.07 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] | ChEMBL. | No reference |
| EC50 (functional) | = 7.709 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] | ChEMBL. | No reference |
| Growth Inhibition (functional) | = 88.163 % | MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. | ChEMBL. | No reference |
| IC50 (functional) | = 182.7 nM | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. IC50s determined for selected compounds. | ChEMBL. | No reference |
| IC50 (functional) | = 443.2 nM | MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. | ChEMBL. | No reference |
| IC50 (functional) | = 473.1 nM | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. IC50s determined for selected compounds. | ChEMBL. | No reference |
| IC50 (functional) | = 696.4375 nM | MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. The IC50 value was extrapolated as the concentration that induced a 50% inhibition of gametocyte viability. | ChEMBL. | No reference |
| IC50 (functional) | = 3494 nM | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. IC50s determined for selected compounds. | ChEMBL. | No reference |
| IC50 (functional) | = 6745 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | = 6745 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | = 6745 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | = 0.222724676132202 uM | MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). | ChEMBL. | No reference |
| IC50 (functional) | = 0.259046316146851 uM | MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. | ChEMBL. | No reference |
| IC50 (functional) | = 1.01106309890747 uM | MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). | ChEMBL. | No reference |
| IC50 (functional) | = 1.0110630989074707 uM | MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). | ChEMBL. | No reference |
| IC50 (functional) | = 1.0142463445663452 uM | MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. | ChEMBL. | No reference |
| IC50 (functional) | = 1.01424634456635 uM | MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. | ChEMBL. | No reference |
| IC50 (functional) | > 2.5 uM | MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. | ChEMBL. | No reference |
| IC50 (functional) | > 2.5 uM | MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. | ChEMBL. | No reference |
| IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] | ChEMBL. | No reference |
| IC50 (functional) | > 30 uM | MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. | ChEMBL. | No reference |
| IC50 (functional) | > 30 uM | MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. | ChEMBL. | No reference |
| Inhibition (functional) | = -7.364678893899182 % | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = -7.36467889389918 % | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 9.02357980648766 % | MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. | ChEMBL. | No reference |
| Inhibition (functional) | = 27.2563103585932 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 32 % | MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). | ChEMBL. | No reference |
| Inhibition (functional) | = 47.1 % | MMV: Screen against Mtb, single point, non replicating, at 25uM | ChEMBL. | No reference |
| Inhibition (functional) | = 83.5782562785574 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 86 % | MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). | ChEMBL. | No reference |
| Inhibition (functional) | = 98.1 % | MMV: Screen against Mtb, single point, replicating, at 25uM | ChEMBL. | No reference |
| MIC90 (functional) | = 16.9 uM | MMV: CRC and MIC90 against Mtb (replicating) | ChEMBL. | No reference |
| MIC90 (functional) | > 100 uM | MMV: CRC and MIC90 against Mtb (non replicating) | ChEMBL. | No reference |
| Potency (functional) | 1.6511 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | 1.6511 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
| Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 11.5821 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
| Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
| Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
| Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
| Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
| Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
| Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Ratio (functional) | = 1.078125 | MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.0587 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.0503 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.012 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Toxicity (functional) | = 4 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| Toxicity (functional) | = 4 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| Toxicity (functional) | = 4 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Trypanosoma cruzi | ChEMBL23 | ||
| Leishmania infantum | ChEMBL23 | ||
| Plasmodium falciparum | ChEMBL23 | ||
| Homo sapiens | ChEMBL23 | ||
| Trypanosoma brucei gambiense | |||
| Plasmodium berghei | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1437888
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.