Detailed information for compound 1339198

Basic information

Technical information
  • TDR Targets ID: 1339198
  • Name: N'-[(1E)-1-[2,4,6-trioxo-1-(phenylmethyl)-1,3 -diazinan-5-ylidene]ethyl]pyridine-4-carbohyd razide
  • MW: 379.369 | Formula: C19H17N5O4
  • H donors: 3 H acceptors: 5 LogP: 1.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccncc1)NN/C(=C/1\C(=O)NC(=O)N(C1=O)Cc1ccccc1)/C
  • InChi: 1S/C19H17N5O4/c1-12(22-23-16(25)14-7-9-20-10-8-14)15-17(26)21-19(28)24(18(15)27)11-13-5-3-2-4-6-13/h2-10,22H,11H2,1H3,(H,23,25)(H,21,26,28)/b15-12+
  • InChiKey: CBFQAURHSLTASO-NTCAYCPXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N'-[1-[2,4,6-trioxo-1-(phenylmethyl)-1,3-diazinan-5-ylidene]ethyl]pyridine-4-carbohydrazide
  • N'-[(1E)-1-[2,4,6-trioxo-1-(phenylmethyl)hexahydropyrimidin-5-ylidene]ethyl]pyridine-4-carbohydrazide
  • N'-[1-[2,4,6-trioxo-1-(phenylmethyl)hexahydropyrimidin-5-ylidene]ethyl]pyridine-4-carbohydrazide
  • N'-[1-[2,4,6-trioxo-1-(phenylmethyl)-5-hexahydropyrimidinylidene]ethyl]-4-pyridinecarbohydrazide
  • N'-[(1E)-1-[2,4,6-trioxo-1-(phenylmethyl)-5-hexahydropyrimidinylidene]ethyl]-4-pyridinecarbohydrazide
  • N'-[1-[1-(benzyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]ethyl]isonicotinohydrazide
  • N'-[(1E)-1-[1-(benzyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]ethyl]isonicotinohydrazide
  • Isonicotinic acid N'-{1-[1-benzyl-2,4,6-trioxo-tetrahydro-pyrimidin-(5E)-ylidene]-ethyl}-hydrazide
  • MLS000763022
  • SMR000438306
  • STOCK4S-05750
  • ZINC05026049

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.003 0.0429 0.051
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0104 0.0124
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0087 0.1493 0.1774
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.003 0.0429 0.051
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.003 0.0429 0.0464
Trypanosoma brucei unspecified product 0.001 0.006 0.0071
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0352 0.0373
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0429 0.051
Giardia lamblia Hypothetical protein 0.003 0.0429 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.1493 0.1774
Plasmodium falciparum phosphatidylinositol 4-kinase 0.003 0.0429 0.8211
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0142 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.3403 0.4044
Brugia malayi jmjC domain containing protein 0.0019 0.0229 0.0272
Giardia lamblia GTOR 0.0461 0.8414 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.003 0.0429 0.0347
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.003 0.0429 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.6227 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.6227 0.74
Onchocerca volvulus 0.0031 0.0455 0.1682
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0009 0.004 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0429 0.051
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0104 0.0124
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.003 0.0429 0.051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0607 0.0721
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0522 0.0621
Schistosoma mansoni cpg binding protein 0.0021 0.027 0.0321
Echinococcus multilocularis dna polymerase eta 0.0033 0.0489 0.0581
Trypanosoma cruzi target of rapamycin kinase 3 0.0367 0.6675 0.7923
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0104 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0104 0.0104
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.003 0.0429 0.0464
Echinococcus multilocularis dna polymerase kappa 0.0014 0.0142 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.2191 0.2604
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0229 0.0229
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.6227 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.6227 0.74
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.003 0.0429 0.0464
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.2191 0.2604
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0104 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.2741 0.3257
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0429 0.0689
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0401 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.2741 0.3257
Echinococcus multilocularis prolyl 4 hydroxylase subunit alpha 1 0.0031 0.0455 0.0541
Entamoeba histolytica protein kinase rad3, putative 0.0087 0.1493 0.1774
Leishmania major hypothetical protein, conserved 0.0031 0.0455 0.0541
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0229 0.0272
Onchocerca volvulus 0.003 0.0429 0.1557
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0104 0.0124
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0251 0.0298
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0229 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0461 0.8414 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0352 0.6744
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0218 0.3915 0.4653
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0028 0.0398 0.0473
Trichomonas vaginalis glucosylceramidase, putative 0.0132 0.2315 0.2751
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.006 0.0071
Brugia malayi nuclear receptor NHR-88 0.0012 0.0104 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0276 0.4979 0.5917
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0028 0.0398 0.0473
Toxoplasma gondii tetratricopeptide repeat-containing protein 0.0031 0.0455 0.0731
Entamoeba histolytica hypothetical protein 0.003 0.0429 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.03 0.542 0.6441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0367 0.6668 0.7924
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0028 0.0398 0.0427
Entamoeba histolytica hypothetical protein 0.003 0.0429 0.051
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.003 0.0429 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.2741 0.3257
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0104 0.0124
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.003 0.0429 0.051
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0142 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.1214 0.1443
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.003 0.0429 0.0347
Brugia malayi jmjC domain containing protein 0.0072 0.1214 0.1443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0367 0.6668 0.7924
Onchocerca volvulus Glucosylceramidase homolog 0.0125 0.2191 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.071 0.0843
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0087 0.1493 0.1774
Brugia malayi CXXC zinc finger family protein 0.0021 0.027 0.0321
Entamoeba histolytica Ran family GTPase 0.0026 0.0352 0.0419
Leishmania major DNA polymerase eta, putative 0.0033 0.0489 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0429 0.051
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.003 0.0429 0.051
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0429 0.0429
Schistosoma mansoni hypothetical protein 0.003 0.0429 0.051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0104 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0104 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0104 0.0124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0104 0.0124
Schistosoma mansoni cpg binding protein 0.0022 0.0292 0.0348
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0087 0.1493 0.1774
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0104 0.0124
Plasmodium falciparum phosphatidylinositol 3-kinase 0.003 0.0429 0.8211
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Brugia malayi jmjC domain containing protein 0.0019 0.0229 0.0272
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0308 0.0494
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0104 0.0124
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0229 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.2169 0.2577
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0155 0.2741 0.3257
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0028 0.0398 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.006 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0489 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0429 0.051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Leishmania major hypothetical protein, unknown function 0.003 0.0429 0.051
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.1192 0.1417
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0233 0.4183 0.4972
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0104 0.0124
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0429 0.051
Loa Loa (eye worm) phosphatidylinositol 3 0.0461 0.8414 0.8414
Brugia malayi steroid hormone receptor 0.0012 0.0104 0.0124
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0429 0.0429
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0229 0.0272
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0142 0.0168
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0461 0.8414 1
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0142 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.006 0.0071
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0104 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0104 0.0124
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.003 0.0429 0.051
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0039 0.0607 0.0607
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0142 0.0168
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0104 0.0124
Schistosoma mansoni rotamase 0.0029 0.041 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.6227 0.74
Loa Loa (eye worm) hypothetical protein 0.0035 0.0522 0.0522
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.003 0.0429 0.051
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0489 0.0536
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.003 0.0429 0.051
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0352 0.6744
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.003 0.0429 0.051
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0104 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.3403 0.4044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.2741 0.3257
Plasmodium falciparum importin beta, putative 0.0035 0.0522 1
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0031 0.0455 0.0496
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.1192 0.1417
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0461 0.8414 1
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0489 0.0581
Toxoplasma gondii histone lysine methyltransferase SET1 0.004 0.0621 0.0997
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0104 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0229 0.0229
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0429 0.051
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.003 0.0429 0.0464
Leishmania major phosphatidylinositol 3-kinase, putative 0.0155 0.2741 0.3257
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0429 0.0689
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0192 0.3424 0.4069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0276 0.4979 0.5917
Schistosoma mansoni hypothetical protein 0.0067 0.1126 0.1339
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0229 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.004 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0104 0.0124
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.003 0.0429 0.051
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0104 0.0124
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0367 0.6675 0.7933
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0607 0.0721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.4928 0.5857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.1493 0.1774
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0429 0.0429
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.003 0.0429 0.051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0429 0.051
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.003 0.0429 0.0464
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.003 0.0429 0.051
Leishmania major importin beta-1 subunit, putative 0.0028 0.0401 0.0476
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0104 0.0124
Leishmania major phosphatidylinositol kinase, putative 0.003 0.0429 0.051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0607 0.0721
Echinococcus granulosus snurportin 1 0.0372 0.6755 0.8028
Echinococcus multilocularis cpg binding protein 0.0022 0.0292 0.0348
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0229 0.0272
Toxoplasma gondii hypoxia- inducible factor prolyl hydroxylase (phd2), putative 0.0031 0.0455 0.0731
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0155 0.2741 0.3225
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0031 0.0455 0.0731
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.6755 0.6755
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.2191 0.2604
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0429 0.0464
Schistosoma mansoni phosphatidylinositol 4-kinase 0.003 0.0429 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.1493 0.1774
Loa Loa (eye worm) hypothetical protein 0.003 0.0429 0.0429
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0607 0.0721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0367 0.6668 0.7924
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0522 0.0839
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0191 0.3403 0.3403
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.003 0.0429 0.051
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.1214 0.1214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.4487 0.5333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0607 0.0721
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.051
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.003 0.0429 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.448 0.5325
Trypanosoma brucei unspecified product 0.0014 0.0142 0.0168
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0029 0.041 0.041
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0229 0.4375
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0087 0.1493 0.1735
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0401 0.0431
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0461 0.8414 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.003 0.0429 0.051
Echinococcus multilocularis Zinc finger, PHD finger 0.003 0.0429 0.051
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0104 0.0124
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0429 0.0689
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0104 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.4487 0.5333
Echinococcus granulosus phd:f box containing protein 0.0019 0.0229 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.6227 0.74
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.003 0.0429 0.051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0461 0.8414 1
Brugia malayi FAT domain containing protein 0.0067 0.1126 0.1339
Brugia malayi jmjC domain containing protein 0.0019 0.0229 0.0272
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0104 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0142 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0104 0.0124
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.1192 0.1417
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0104 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0229 0.0229
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0155 0.2741 0.3257
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0229 0.0229
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0097 0.1677 0.2693
Echinococcus granulosus prolyl 4 hydroxylase subunit alpha 1 0.0031 0.0455 0.0541
Schistosoma mansoni coup transcription factor 0.0012 0.0104 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0104 0.0124
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.003 0.0429 0.051
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.003 0.0429 0.051
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0352 0.0352
Schistosoma mansoni hypothetical protein 0.0372 0.6755 0.8028
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0142 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.4928 0.5857
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0229 0.0367
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0489 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.6227 0.74
Schistosoma mansoni ran 0.0026 0.0352 0.0419
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0352 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.4487 0.5333
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.1126 0.1339
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.2191 0.2604
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0401 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0104 0.0124
Loa Loa (eye worm) hypothetical protein 0.0057 0.0942 0.0942
Schistosoma mansoni prolyl 4-hydroxylase alpha subunit 1 0.0031 0.0455 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0461 0.8414 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0367 0.6675 0.7933
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0104 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0142 0.0121
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0229 0.0367
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.003 0.0429 0.051
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0394 0.7166 0.8517
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.003 0.0429 0.051
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.2191 0.2604
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0104 0.0124
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.003 0.0429 0.051
Leishmania major phosphatidylinositol 4-kinase, putative 0.003 0.0429 0.051
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0104 0.0124
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.027 0.027
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0352 0.0566
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0461 0.8414 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.003 0.0429 0.051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0229 0.0229
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0229 0.0272
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0142 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0104 0.0104
Trichomonas vaginalis rotamase, putative 0.0028 0.0398 0.0473
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0104 0.0104
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0229 0.0272
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.1214 0.1443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0104 0.0104
Brugia malayi Importin beta-1 subunit 0.0035 0.0522 0.0621
Schistosoma mansoni jumonji domain containing protein 0.0071 0.1192 0.1417
Loa Loa (eye worm) hypothetical protein 0.0031 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.003 0.0429 0.0429
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.051
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0461 0.8414 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0104 0.0104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0104 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.3403 0.4044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0401 0.0476
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.003 0.0429 0.051
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0142 0.0168
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.003 0.0429 0.051
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0155 0.2741 0.3257
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.003 0.0429 0.051
Echinococcus granulosus dna polymerase eta 0.0033 0.0489 0.0581
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0429 0.051
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0461 0.8414 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0104 0.0104
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0229 0.0225
Echinococcus granulosus cpg binding protein 0.0022 0.0292 0.0348
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.8211
Trichomonas vaginalis DNA polymerase eta, putative 0.0014 0.0142 0.0168
Entamoeba histolytica hypothetical protein 0.0087 0.1493 0.1774
Leishmania major DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.003 0.0429 0.8211
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0142 0.0168
Brugia malayi jmjC domain containing protein 0.0019 0.0229 0.0272
Echinococcus granulosus serine protein kinase ATM 0.0087 0.1493 0.1774
Entamoeba histolytica hypothetical protein 0.003 0.0429 0.051
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0104 0.0124
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.003 0.0429 0.0464
Onchocerca volvulus 0.003 0.0429 0.1557
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0104 0.0124
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0104 0.0124
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.003 0.0429 0.051
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0352 0.0419
Schistosoma mansoni phosphatidylinositol 4-kinase 0.003 0.0429 0.051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0607 0.0721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0104 0.0124
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0352 0.0419
Loa Loa (eye worm) hypothetical protein 0.0094 0.1618 0.1618
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0104 0.0124
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0308 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0942 0.1119
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0461 0.8414 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0191 0.3403 0.4044
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0429 0.0429
Trichomonas vaginalis rotamase, putative 0.0029 0.041 0.0488
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0104 0.0124
Echinococcus multilocularis expressed protein 0.0029 0.041 0.0488
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0142 0.0168
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0028 0.0398 0.0427
Leishmania major DNA polymerase eta, putative 0.0023 0.0308 0.0366
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0104 0.0124
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0104 0.0124
Trichomonas vaginalis ran, putative 0.0026 0.0352 0.0419
Leishmania major hypothetical protein, unknown function 0.0031 0.0455 0.0541
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0009 0.004 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0429 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.448 0.5325
Brugia malayi prolyl 4-hydroxylase 0.0031 0.0455 0.0541
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.003 0.0429 0.0429
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0039 0.0607 0.0721
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.3403 0.4044
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0104 0.0124
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0067 0.1126 0.1339
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0429 0.0689
Schistosoma mansoni importin beta-1 0.0035 0.0522 0.0621
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0461 0.8414 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0429 0.0689
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Schistosoma mansoni ran 0.0026 0.0352 0.0419
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0104 0.0124
Plasmodium vivax hypothetical protein, conserved 0.003 0.0429 0.8211
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0155 0.2741 0.3257
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.003 0.0429 0.051
Loa Loa (eye worm) hypothetical protein 0.0067 0.1126 0.1126
Echinococcus granulosus expressed protein 0.0029 0.041 0.0488
Brugia malayi ecdysteroid receptor 0.0012 0.0104 0.0124
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0229 0.0272
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0229 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0104 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0309 0.5604 0.666
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.3403 0.4044
Leishmania major hypothetical protein, conserved 0.0019 0.0229 0.0272
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.003 0.0429 0.051
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0352 0.0419
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.003 0.0429 0.051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0104 0.0124
Plasmodium vivax hypothetical protein 0.003 0.0429 0.8211
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.1677 0.1993
Toxoplasma gondii FATC domain-containing protein 0.0087 0.1493 0.2397
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.2741 0.3257
Leishmania major hypothetical protein, conserved 0.003 0.0429 0.051
Echinococcus multilocularis serine protein kinase ATM 0.0087 0.1493 0.1774
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.003 0.0429 0.8211
Entamoeba histolytica hypothetical protein 0.003 0.0429 0.051
Entamoeba histolytica hypothetical protein 0.0028 0.0401 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.2741 0.3257
Echinococcus granulosus dna polymerase kappa 0.0014 0.0142 0.0168
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0104 0.0124
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0087 0.1493 0.1774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0367 0.6668 0.7924
Echinococcus granulosus dnaJ subfamily B 0.0302 0.546 0.6489
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0251 0.0298
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.003 0.0429 0.051
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0229 0.0272
Echinococcus multilocularis snurportin 1 0.0372 0.6755 0.8028
Echinococcus granulosus importin subunit beta 1 0.0035 0.0522 0.0621
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.2191 0.2604
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0229 0.0229
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0057 0.0942 0.1077
Echinococcus granulosus tachykinin peptides receptor 99D 0.0233 0.4183 0.4972
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0142 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0942 0.1119
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0461 0.8414 1
Trypanosoma brucei unspecified product 0.001 0.006 0.0071
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0522 0.0621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0607 0.0721
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.003 0.0429 0.0464
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0229 0.0272
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0429 0.051
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0461 0.8414 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0142 0.0168
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0522 0.0621
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0104 0.0124
Leishmania major GTP-binding protein, putative 0.0026 0.0352 0.0419
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0031 0.0455 0.0496
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0087 0.1493 0.1774
Loa Loa (eye worm) prolyl 4-hydroxylase 2 0.0031 0.0455 0.0455
Schistosoma mansoni hypothetical protein 0.0302 0.546 0.6489
Loa Loa (eye worm) phosphatidylinositol kinase 0.003 0.0429 0.0429
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0067 0.1126 0.1339
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.003 0.0429 0.051
Schistosoma mansoni fkbp-rapamycin associated protein 0.0087 0.1493 0.1774
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0087 0.1493 0.1735
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.003 0.0429 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0276 0.4979 0.5917
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Loa Loa (eye worm) hypothetical protein 0.0097 0.1677 0.1677
Plasmodium vivax importin-beta 2, putative 0.0035 0.0522 1
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.2191 0.2604
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0142 0.0168
Toxoplasma gondii target of rapamycin (TOR), putative 0.0343 0.6227 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1493 0.1493
Plasmodium vivax JmjC domain containing protein 0.0019 0.0229 0.4375
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.041 0.0488
Onchocerca volvulus 0.0021 0.027 0.0796
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0009 0.004 0.0064
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0031 0.0455 0.0731
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.003 0.0429 0.051
Echinococcus multilocularis 0.003 0.0429 0.051
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0429 0.8211
Brugia malayi nuclear hormone receptor 0.0012 0.0104 0.0124
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.1493 0.1774
Leishmania major phosphatidylinositol kinase related protein, putative 0.003 0.0429 0.051
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0104 0.0124
Brugia malayi jmjC domain containing protein 0.0071 0.1192 0.1417
Echinococcus multilocularis dnaJ subfamily B 0.0302 0.546 0.6489
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.1493 0.1774
Trichomonas vaginalis glucosylceramidase, putative 0.0132 0.2315 0.2751
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0461 0.8414 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0367 0.6668 0.7924
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0429 0.051
Toxoplasma gondii peptidylprolyl isomerase 0.0028 0.0398 0.0639
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0429 0.0429
Schistosoma mansoni cpg binding protein 0.0022 0.0292 0.0348
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0155 0.2741 0.3225
Mycobacterium leprae conserved hypothetical protein 0.003 0.0429 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0461 0.8414 1
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0229 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0104 0.0104
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.2741 0.2741
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0352 0.0419
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.4487 0.5333
Trypanosoma brucei 2OG-Fe(II) oxygenase superfamily, putative 0.0031 0.0455 0.0541
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.003 0.0429 0.051
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0029 0.041 0.0488
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0142 0.0142
Brugia malayi RNA, U transporter 1 0.0099 0.171 0.2032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0142 0.0121
Schistosoma mansoni DNA polymerase eta 0.0033 0.0489 0.0581
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.1214 0.1443
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.051
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0429 0.051
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0429 0.8211
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0429 0.051
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0155 0.2741 0.3257
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0142 0.0168
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0352 0.0255
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0229 0.0272
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.003 0.0429 0.051
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.3403 0.4044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.448 0.5325
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0014 0.0142 0.0168
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0429 0.051
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0155 0.2741 0.3257
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.003 0.0429 0.051

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 32.6294 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.