Detailed information for compound 1342411

Basic information

Technical information
  • TDR Targets ID: 1342411
  • Name: 5-[2-[(4-methoxyphenyl)methylsulfanyl]ethyl]- 4-phenyl-2H-1,2,4-triazole-3-thione
  • MW: 357.493 | Formula: C18H19N3OS2
  • H donors: 0 H acceptors: 2 LogP: 3.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CSCCc1nnc(n1c1ccccc1)S
  • InChi: 1S/C18H19N3OS2/c1-22-16-9-7-14(8-10-16)13-24-12-11-17-19-20-18(23)21(17)15-5-3-2-4-6-15/h2-10H,11-13H2,1H3,(H,20,23)
  • InChiKey: CVFVVGXLKFXKNE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[2-[(4-methoxyphenyl)methylthio]ethyl]-4-phenyl-2H-1,2,4-triazole-3-thione
  • 5-[2-[(4-methoxybenzyl)thio]ethyl]-4-phenyl-2H-1,2,4-triazole-3-thione
  • SMR000296365
  • 5-{2-[(4-methoxybenzyl)thio]ethyl}-4-phenyl-4H-1,2,4-triazole-3-thiol
  • ZINC02879088
  • MLS000664657

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.2749 0.2749
Brugia malayi mbt repeat family protein 0.0058 0.0566 0.1337
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0019 0.0075 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0617 0.1246
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0188
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.018
Mycobacterium tuberculosis Conserved protein 0.004 0.0336 0.0752
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0617 0.1525
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1075 0.2655
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0825
Brugia malayi hypothetical protein 0.003 0.0216 0.0465
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0122 0.0188
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0122 0.0118
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0156 0.1829 0.4418
Echinococcus granulosus lamin dm0 0.003 0.0207 0.0513
Loa Loa (eye worm) hypothetical protein 0.003 0.0207 0.0508
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0296
Onchocerca volvulus 0.003 0.0207 0.0386
Leishmania major hypothetical protein, conserved 0.004 0.0336 0.0763
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0205 0.0438
Mycobacterium ulcerans cystathionine beta-synthase 0.0019 0.0075 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0216 0.0453
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0825
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.3134 0.7732
Schistosoma mansoni lamin 0.003 0.0207 0.0478
Echinococcus granulosus zinc finger protein 0.002 0.0087 0.0214
Schistosoma mansoni chloride channel protein 0.0019 0.0075 0.0172
Mycobacterium tuberculosis Conserved protein 0.0019 0.0075 0.0101
Treponema pallidum hemolysin (tlyC) 0.0019 0.0075 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.018
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0328 0.4045 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0639 0.1507
Plasmodium falciparum protein MAM3, putative 0.0019 0.0075 0.0076
Mycobacterium ulcerans transcriptional regulator 0.0019 0.0075 0.0071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0398 0.0984
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0029 0.0068
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0617 0.1246
Brugia malayi GMP reductase 0.0136 0.1578 0.3857
Onchocerca volvulus 0.0234 0.2844 0.8062
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0566 0.14
Echinococcus granulosus intermediate filament protein 0.003 0.0207 0.0513
Schistosoma mansoni hypothetical protein 0.0031 0.022 0.0507
Loa Loa (eye worm) hypothetical protein 0.0286 0.3504 0.8661
Loa Loa (eye worm) MBCTL1 0.0066 0.0669 0.165
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0328 0.4045 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.018
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0009 0.0022
Brugia malayi Bromodomain containing protein 0.004 0.0338 0.0768
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0205 0.0397
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0019 0.0075 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0188
Schistosoma mansoni zinc finger protein 0.0016 0.0029 0.0068
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0019 0.0075 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0308 0.3794 1
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0019 0.0075 0.0113
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0019 0.0075 0.0185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0398 0.0918
Mycobacterium tuberculosis Conserved protein 0.0019 0.0075 0.0101
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0566 0.0566
Schistosoma mansoni protein kinase subunit gamma 0.0019 0.0075 0.0172
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0019 0.0075 0.0113
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.1068 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0336 0.0752
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0019 0.0075 0.0075
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0019 0.0075 0.0113
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0019 0.0075 0.0172
Schistosoma mansoni bromodomain containing protein 0.0066 0.0673 0.1552
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0617 0.1463
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0354 0.0876
Schistosoma mansoni zinc finger protein 0.002 0.0087 0.02
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0398 0.0918
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0825
Schistosoma mansoni intermediate filament proteins 0.003 0.0207 0.0478
Echinococcus multilocularis musashi 0.003 0.0207 0.0207
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0336 0.0825
Mycobacterium ulcerans beta-lactamase 0.004 0.0336 0.0724
Onchocerca volvulus 0.004 0.0336 0.076
Schistosoma mansoni chloride channel protein 0.0019 0.0075 0.0172
Schistosoma mansoni hypothetical protein 0.0021 0.0101 0.0233
Loa Loa (eye worm) beta-lactamase 0.004 0.0336 0.0825
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0019 0.0075 0.0075
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0566 0.1306
Plasmodium vivax SET domain protein, putative 0.0036 0.0289 0.0646
Brugia malayi Bromodomain containing protein 0.0078 0.083 0.1994
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0617 0.0617
Trypanosoma cruzi GMP reductase 0.0328 0.4045 1
Treponema pallidum Mg2+ transport protein (mgtE) 0.0019 0.0075 0.5
Onchocerca volvulus 0.0058 0.0575 0.1455
Brugia malayi HSF-type DNA-binding domain containing protein 0.0097 0.1068 0.2587
Mycobacterium ulcerans lipase LipD 0.004 0.0336 0.0724
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0336 0.0724
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0172 0.204 0.4951
Chlamydia trachomatis CBS domain-containing protein 0.0019 0.0075 1
Onchocerca volvulus 0.003 0.0207 0.0386
Loa Loa (eye worm) hypothetical protein 0.0066 0.0669 0.165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0296
Brugia malayi hypothetical protein 0.002 0.0077 0.0119
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0617 0.1463
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0398 0.0984
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0669 0.1543
Mycobacterium ulcerans hypothetical protein 0.003 0.0205 0.0397
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0669 0.0669
Onchocerca volvulus 0.0023 0.0122 0.0136
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0625 0.1545
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0354 0.0876
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0122 0.023
Brugia malayi CLC chloride channel protein 0.0019 0.0075 0.0113
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.3093 0.7627
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0216 0.0466
Echinococcus multilocularis protein patched 0.0041 0.0354 0.0354
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0398 0.098
Brugia malayi ancient conserved domain protein 4 0.0019 0.0075 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0336 0.0774
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0617 0.1463
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0328 0.4045 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0339 0.0833
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3504 0.8662
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0336 0.0763
Leishmania major hypothetical protein, conserved 0.003 0.0216 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0517 0.1193
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0289 0.0289
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0328 0.4045 0.4045
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0101 0.0244
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0328 0.4045 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0566 0.1306
Brugia malayi intermediate filament protein 0.003 0.0207 0.0443
Echinococcus multilocularis zinc finger protein 0.002 0.0087 0.0087
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0328 0.4045 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0617 0.1246
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0061 0.0146
Brugia malayi beta-lactamase family protein 0.004 0.0336 0.0763
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0617 0.1525
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0122 0.0218
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0216 0.0453
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0639 0.142
Brugia malayi hypothetical protein 0.0286 0.3504 0.8652
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0172 0.204 0.5002
Brugia malayi Pre-SET motif family protein 0.0251 0.3063 0.7554
Onchocerca volvulus Putative GMP reductase 0.0136 0.1578 0.4377
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0328 0.4045 0.9328
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0336 0.0752
Toxoplasma gondii ABC1 family protein 0.004 0.0336 0.0657
Trypanosoma brucei protein kinase, putative 0.0062 0.0617 0.1463
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0126 0.0313
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0336 0.0752
Mycobacterium ulcerans hypothetical protein 0.004 0.0336 0.0724
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0019 0.0075 0.0172
Loa Loa (eye worm) hypothetical protein 0.0042 0.0371 0.0912
Loa Loa (eye worm) chloride channel 3 0.0019 0.0075 0.018
Trypanosoma cruzi chloride channel protein, putative 0.0019 0.0075 0.0113
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0207 0.0508
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.1068 1
Schistosoma mansoni hypothetical protein 0.0281 0.3439 0.7932
Loa Loa (eye worm) intermediate filament protein 0.003 0.0207 0.0508
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0669 0.0669
Chlamydia trachomatis Mg++ transporter 0.0019 0.0075 1
Trypanosoma cruzi chloride channel protein, putative 0.0019 0.0075 0.0113
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0009 0.0009
Echinococcus multilocularis transcription factor eb 0.0105 0.1179 0.1179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0289 0.0666
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0122 0.0188
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0336 0.0395
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0617 0.1463
Trichomonas vaginalis set domain proteins, putative 0.0286 0.351 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0122 0.023
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0825
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0019 0.0075 0.0113
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.022 0.0475
Echinococcus multilocularis lamin 0.003 0.0207 0.0207
Brugia malayi ancient conserved domain protein 2 0.0019 0.0075 0.0113
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0053 0.0131
Schistosoma mansoni hypothetical protein 0.0031 0.022 0.0507
Echinococcus granulosus X box binding protein 1 0.0281 0.3439 0.8503
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0019 0.0075 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0639 0.1481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0398 0.0398
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0566 0.1396
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0336 0.0752
Echinococcus granulosus H:Cl exchange transporter 7 0.0019 0.0075 0.0185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.011
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0122 0.023
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0336 0.0724
Onchocerca volvulus 0.0036 0.0289 0.0623
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0825
Trypanosoma brucei GMP reductase 0.0328 0.4045 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0122 0.0218
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1079 0.2488
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0205 0.0397
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0566 0.0566
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0019 0.0075 0.0172
Schistosoma mansoni hypothetical protein 0.0031 0.022 0.0507
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.159 0.159
Mycobacterium ulcerans hypothetical protein 0.0019 0.0075 0.0071
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0354 0.0354
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.106 0.2565
Echinococcus granulosus GPCR family 2 0.0031 0.022 0.0544
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.011
Loa Loa (eye worm) hypothetical protein 0.0074 0.0773 0.1906
Echinococcus granulosus H:Cl exchange transporter 4 0.0019 0.0075 0.0185
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0639 0.1473
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0019 0.0075 0.0101
Mycobacterium leprae Probable lipase LipE 0.004 0.0336 0.0657
Onchocerca volvulus 0.0286 0.351 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0474 0.1166
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0019 0.0075 0.0101
Echinococcus granulosus expressed conserved protein 0.009 0.0985 0.2434
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0617 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0053 0.0122
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0122 0.0118
Loa Loa (eye worm) IMP dehydrogenase 1 0.0328 0.4045 1
Leishmania major chloride channel protein, putative 0.0019 0.0075 0.0113
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0136 0.1578 0.3857
Mycobacterium tuberculosis Conserved protein 0.0019 0.0075 0.0101
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0308 0.3794 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1075 0.2604
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0019 0.0075 0.0075
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0566 0.1431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.022 0.0544
Brugia malayi Voltage gated chloride channel family protein 0.0019 0.0075 0.0113
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0126 0.0126
Brugia malayi MAP kinase sur-1 0.0062 0.0617 0.1463
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0289 0.0539
Leishmania major guanosine monophosphate reductase 0.0328 0.4045 1
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0336 0.0752
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0289 0.0666
Echinococcus multilocularis protein dispatched 1 0.0047 0.0429 0.0429
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0575 0.1358
Loa Loa (eye worm) hypothetical protein 0.0105 0.1172 0.2894
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0122 0.023
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0019 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0044 0.0396 0.0975
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0205 0.0508
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0639 0.1473
Schistosoma mansoni survival motor neuron protein 0.0058 0.0575 0.1325
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0328 0.4045 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0122 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.022 0.0539
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0336 0.0752
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0019 0.0075 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0354 0.0451
Leishmania major chloride channel protein, putative 0.0019 0.0075 0.0113
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0306 0.0757
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0336 0.0395
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0328 0.4045 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.022 0.0475
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0105 0.1179 0.2862
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0019 0.0075 0.0101
Mycobacterium ulcerans hypothetical protein 0.003 0.0205 0.0397
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0398 0.0918
Brugia malayi PHD-finger family protein 0.0026 0.0158 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0617 0.1423
Brugia malayi beta-lactamase family protein 0.004 0.0336 0.0763
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0566 0.14
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0097 0.1068 0.2892
Trypanosoma cruzi chloride channel protein, putative 0.0019 0.0075 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0398 0.0918
Toxoplasma gondii IMP dehydrogenas 0.0328 0.4045 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0216 0.0466
Leishmania major inosine-5-monophosphate dehydrogenase 0.0328 0.4045 1
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.3134 0.7732
Loa Loa (eye worm) hypothetical protein 0.0029 0.02 0.049
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.3134 0.7732
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0625 0.0625
Mycobacterium tuberculosis Conserved protein 0.004 0.0336 0.0752
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0156 0.1829 0.4458
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0105 0.1172 0.2894
Schistosoma mansoni lamin 0.003 0.0207 0.0478
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0336 0.0763
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0639 0.1481
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0019 0.0075 0.0185
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.022 0.0539
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0669 0.1654
Loa Loa (eye worm) hypothetical protein 0.003 0.0216 0.053
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.159 0.393
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0336 0.0395
Echinococcus granulosus lamin 0.003 0.0207 0.0513
Brugia malayi beta-lactamase 0.004 0.0336 0.0763
Schistosoma mansoni hypothetical protein 0.0066 0.0679 0.1567
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0308 0.3794 0.9373
Trypanosoma cruzi GMP reductase 0.0328 0.4045 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0669 0.1654
Brugia malayi CHE-14 protein 0.0041 0.0354 0.0809
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.022 0.022
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0122 0.023
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0617 0.0617
Mycobacterium ulcerans hypothetical protein 0.0019 0.0075 0.0071
Trypanosoma cruzi chloride channel protein, putative 0.0019 0.0075 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0336 0.0763
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0097 0.1068 0.2637
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0272 0.0671
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0122 0.0188
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.106 0.106
Schistosoma mansoni hypothetical protein 0.004 0.0335 0.0773
Leishmania major CBS domain protein, conserved 0.0019 0.0075 0.0113
Echinococcus multilocularis lamin dm0 0.003 0.0207 0.0207
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0566 0.1306
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0053 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0617 0.1246
Brugia malayi mbt repeat family protein 0.0058 0.0566 0.1337
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0328 0.4045 1
Onchocerca volvulus 0.004 0.0336 0.076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0517 0.1193
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0517 0.1279
Schistosoma mansoni hypothetical protein 0.004 0.0335 0.0773
Brugia malayi CBS domain containing protein 0.0019 0.0075 0.0113
Echinococcus granulosus transcription factor eb 0.0105 0.1179 0.2914
Loa Loa (eye worm) hypothetical protein 0.0066 0.0679 0.1675
Brugia malayi loechrig isoform VII 0.0019 0.0075 0.0113
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0296
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3504 0.3504
Trichomonas vaginalis esterase, putative 0.004 0.0336 0.0395
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0336 0.0395
Echinococcus multilocularis GPCR, family 2 0.0031 0.022 0.022
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0122 0.0188
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0328 0.4045 1
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0019 0.0075 0.0101
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0053 0.0122
Loa Loa (eye worm) hypothetical protein 0.0096 0.106 0.2616
Schistosoma mansoni hypothetical protein 0.035 0.4336 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0669 0.1593
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0336 0.083
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0205 0.0397
Onchocerca volvulus 0.0058 0.0566 0.1431
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0019 0.0075 0.0101
Schistosoma mansoni patched 1 0.0041 0.0354 0.0817
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0517 0.0517
Loa Loa (eye worm) loechrig isoform VII 0.0019 0.0075 0.018
Schistosoma mansoni hypothetical protein 0.0031 0.022 0.0507
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0207 0.0443
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.011
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0054 0.0517 0.1275
Loa Loa (eye worm) hypothetical protein 0.0058 0.0566 0.1396
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0205 0.0426
Mycobacterium leprae conserved hypothetical protein 0.004 0.0336 0.0657
Plasmodium vivax hypothetical protein, conserved 0.004 0.0336 0.0772
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0871
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0354 0.0871
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0639 0.1517
Schistosoma mansoni chloride channel protein 0.0019 0.0075 0.0172
Leishmania major hypothetical protein, conserved 0.0019 0.0075 0.0113
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.1068 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0617 0.1366
Leishmania major hypothetical protein, conserved 0.0257 0.3134 0.7732
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0328 0.4045 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0136 0.1578 0.3857
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0205 0.0438
Schistosoma mansoni hypothetical protein 0.0058 0.0575 0.1325
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0617 0.1463
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0336 0.0763
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0336 0.0395
Mycobacterium ulcerans hypothetical protein 0.0019 0.0075 0.0071
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0617 0.1521
Brugia malayi Pax transcription factor protein 2 0.0234 0.2844 0.701
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0046 0.003
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0825
Mycobacterium tuberculosis Conserved protein 0.003 0.0205 0.0426
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.022 0.0544
Loa Loa (eye worm) hypothetical protein 0.0097 0.1075 0.2655
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0122 0.0188
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0019 0.0075 0.0101
Mycobacterium ulcerans hypothetical protein 0.0023 0.0122 0.0188
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0205 0.0438
Echinococcus multilocularis X box binding protein 1 0.0281 0.3439 0.3439
Onchocerca volvulus 0.004 0.0336 0.076
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0216 0.0357
Echinococcus granulosus H:Cl exchange transporter 3 0.0019 0.0075 0.0185
Schistosoma mansoni hypothetical protein 0.004 0.0335 0.0773
Loa Loa (eye worm) chloride channel protein 7 0.0019 0.0075 0.018
Schistosoma mansoni hypothetical protein 0.004 0.0335 0.0773
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0617 0.1463
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.011
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0617 0.1463
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0126 0.0292
Brugia malayi Pre-SET motif family protein 0.0036 0.0289 0.0645
Echinococcus multilocularis expressed conserved protein 0.009 0.0985 0.0985
Brugia malayi chloride channel protein 7 0.0019 0.0075 0.0113
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.022 0.022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0639 0.0639
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.2749 0.6796
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.106 0.2619
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0639 0.1579
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0639 0.1481
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.106 0.9907
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1075 0.2604
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0216 0.0453
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0336 0.0774
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0679 0.1619
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0336 0.0752
Loa Loa (eye worm) GMP reductase 0.0136 0.1578 0.3899
Mycobacterium tuberculosis Conserved protein 0.004 0.0336 0.0752
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3063 0.757
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0216 0.0466
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.2844 0.703

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.2284 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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