Detailed information for compound 1356387

Basic information

Technical information
  • TDR Targets ID: 1356387
  • Name: Oprea1_322262
  • MW: 344.406 | Formula: C22H20N2O2
  • H donors: 0 H acceptors: 2 LogP: 3.17 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1c2ccccc2c2c3c1c(ccc3n(c(=O)c2)C)N1CCCCC1
  • InChi: 1S/C22H20N2O2/c1-23-17-9-10-18(24-11-5-2-6-12-24)21-20(17)16(13-19(23)25)14-7-3-4-8-15(14)22(21)26/h3-4,7-10,13H,2,5-6,11-12H2,1H3
  • InChiKey: ZMXVWFFEPNMQNW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • MLS001029970
  • SMR000426980
  • ChemDiv1_019414
  • Oprea1_245940
  • ZINC02348208

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens S100 calcium binding protein A4 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens Wolf-Hirschhorn syndrome candidate 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei gambiense calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_130029 All targets in OG5_130029
Candida albicans similar to acyl-CoA ligase-like proteins in a variety of plant pathogens and to S. cerevisiae YOR093C Get druggable targets OG5_127582 All targets in OG5_127582
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei gambiense calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei variant surface glycoprotein (VSG), putative Get druggable targets OG5_130635 All targets in OG5_130635
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Histone-lysine N-methyltransferase NSD3, putative Get druggable targets OG5_130029 All targets in OG5_130029
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative Get druggable targets OG5_130029 All targets in OG5_130029
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_127582 All targets in OG5_127582
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Schistosoma mansoni disco-interacting protein 2 (dip2) Get druggable targets OG5_127582 All targets in OG5_127582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma brucei calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Get druggable targets OG5_127582 All targets in OG5_127582
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni SET domain protein Get druggable targets OG5_130029 All targets in OG5_130029
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi Disco-interacting protein 2 homolog Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis disco interacting protein 2 Get druggable targets OG5_127582 All targets in OG5_127582
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum protein with 4 PHD domains plus a SET domain and associated cysteine cluster at the C-terminus Get druggable targets OG5_130029 All targets in OG5_130029
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_127582 All targets in OG5_127582
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans putative fatty-acid--CoA ligase Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_127582 All targets in OG5_127582
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to acyl-CoA ligase-like proteins in a variety of plant pathogens and to S. cerevisiae YOR093C Get druggable targets OG5_127582 All targets in OG5_127582
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_130029 All targets in OG5_130029
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi calpain cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania infantum calpain-like cysteine peptidase Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_127582 All targets in OG5_127582
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus granulosus disco interacting protein 2 Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma brucei hypothetical protein Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_127582 All targets in OG5_127582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei gambiense Get druggable targets OG5_130635 All targets in OG5_130635
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania infantum hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Trichomonas vaginalis protein phosphatase type 2C, putative S100 calcium binding protein A4 101 aa 90 aa 24.4 %
Leishmania donovani hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 580 aa 544 aa 23.5 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0048 0.009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0042 0.0133
Schistosoma mansoni chromobox protein 0.0014 0.0004 0.0001
Brugia malayi chromobox protein homolog 3 0.0047 0.035 0.0641
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.1435 0.1435
Brugia malayi Pre-SET motif family protein 0.0253 0.2485 0.4599
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0485 0.0891
Echinococcus multilocularis pyruvate kinase 0.0021 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0516
Loa Loa (eye worm) hypothetical protein 0.0058 0.0458 0.0848
Leishmania major pyruvate kinase 0.004 0.0279 0.1869
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0085 0.0286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0103 0.0414
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0279 0.0509
Leishmania major hypothetical protein, conserved 0.003 0.0177 0.1026
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0103 0.0414
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1261 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0038 0.0256 0.0256
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0733 0.1357
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0004 0.0001
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0279 0.0509
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0066 0.054 0.1001
Leishmania major pyruvate kinase 0.004 0.0279 0.1869
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0269 0.1958
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0687 1
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4975 0.5861
Schistosoma mansoni ets-related 0.0265 0.261 0.3072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0628 0.0628
Brugia malayi hypothetical protein 0.0043 0.0311 0.0569
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0599 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0075 0.0075
Plasmodium vivax SET domain protein, putative 0.0038 0.0256 0.9189
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0164 0.0164
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0177 0.6287
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0038 0.0256 0.4241
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0279 1
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0152 0.2172
Echinococcus multilocularis pyruvate kinase 0.004 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.0019 0.0059 0.0066
Brugia malayi Ets-domain containing protein 0.0087 0.0767 0.1414
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.2212 0.2605
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0733 0.2565
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0339 0.0339
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.1261 1
Echinococcus granulosus chromobox protein 1 0.0084 0.0733 0.0863
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0177 0.6287
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0279 0.1869
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0469 0.055
Brugia malayi PHD-finger family protein 0.0032 0.0193 0.0351
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0177 0.6287
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0279 0.0509
Loa Loa (eye worm) pyruvate kinase 0.004 0.0279 0.0516
Schistosoma mansoni SET domain protein 0.0019 0.006 0.0068
Echinococcus multilocularis dna polymerase eta 0.0023 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.018 0.1729 0.3202
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.035 0.1217
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0687 0.0806
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0082 0.0152
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0221 0.026
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1261 1
Schistosoma mansoni hypothetical protein 0.0494 0.4975 0.5859
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0027 0.0145 0.24
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0145 0.24
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0103 0.0414
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0177 0.1207
Giardia lamblia Pyruvate kinase 0.004 0.0279 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0145 0.24
Loa Loa (eye worm) hypothetical protein 0.006 0.0485 0.0898
Leishmania major DNA polymerase kappa, putative 0.0023 0.0103 0.0414
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0279 0.0966
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0399 0.0467
Brugia malayi hypothetical protein 0.002 0.0065 0.0113
Onchocerca volvulus 0.0037 0.0244 0.0445
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0145 0.24
Echinococcus multilocularis protein quaking 0.0033 0.0202 0.0202
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0015 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0047 0.035 0.0648
Entamoeba histolytica hypothetical protein 0.0043 0.0311 0.45
Brugia malayi hypothetical protein 0.003 0.0177 0.032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0103 0.0183
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0269 0.1792
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0145 0.24
Echinococcus granulosus zinc finger protein 0.0026 0.0127 0.0149
Loa Loa (eye worm) hypothetical protein 0.0059 0.0469 0.0869
Echinococcus granulosus geminin 0.0205 0.198 0.2332
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0387 0.1348
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0145 0.24
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.054 0.0637
Echinococcus granulosus Chromo domain 0.0014 0.0004 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1261 1
Schistosoma mansoni hypothetical protein 0.0019 0.0059 0.0066
Brugia malayi Pre-SET motif family protein 0.0038 0.0256 0.0468
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8489 0.8489
Schistosoma mansoni cpg binding protein 0.0035 0.0221 0.0257
Loa Loa (eye worm) hypothetical protein 0.0041 0.0288 0.0533
Trypanosoma brucei hypothetical protein 0.0135 0.1261 1
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0004 0.0004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0387 0.071
Trichomonas vaginalis rotamase, putative 0.004 0.0279 0.0968
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0458 0.0539
Schistosoma mansoni hypothetical protein 0.0014 0.0004 0.0001
Schistosoma mansoni pyruvate kinase 0.004 0.0279 0.0325
Echinococcus multilocularis chromobox protein 1 0.0084 0.0733 0.0733
Echinococcus multilocularis pyruvate kinase 0.0021 0.0076 0.0076
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0003 0.0003
Brugia malayi Ets-domain containing protein 0.0087 0.0767 0.1414
Brugia malayi CHD4 protein 0.0018 0.0048 0.0082
Loa Loa (eye worm) runx1 0.0067 0.0556 0.103
Trichomonas vaginalis rotamase, putative 0.0039 0.0269 0.0934
Onchocerca volvulus 0.0014 0.0004 0.000000028976
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1261 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0085 0.0286
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0085 0.0286
Brugia malayi tumor suppressor. 0.0388 0.3882 0.7188
Echinococcus multilocularis muscleblind protein 1 0.018 0.1729 0.1729
Schistosoma mansoni gabp alpha 0.0087 0.0767 0.09
Loa Loa (eye worm) hypothetical protein 0.0037 0.0244 0.0452
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0458 0.0848
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0075 0.0636 0.1177
Schistosoma mansoni bromodomain containing protein 0.0078 0.0673 0.079
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0311 0.0366
Echinococcus multilocularis peregrin 0.0014 0.001 0.001
Schistosoma mansoni eyes absent homolog 0.0106 0.0963 0.1132
Schistosoma mansoni hypothetical protein 0.0025 0.0119 0.0137
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0145 0.24
Schistosoma mansoni cpg binding protein 0.0039 0.0265 0.0309
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8489 1
Schistosoma mansoni pyruvate kinase 0.0021 0.0076 0.0086
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.1562 0.1562
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0127 0.1368
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0059 0.0059
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0103 0.019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0007
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0202 0.0366
Schistosoma mansoni zinc finger protein 0.0026 0.0127 0.0146
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0015 0.0016 0.0019
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.1435 0.1691
Trypanosoma brucei calpain, putative 0.0135 0.1261 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0027 0.0145 0.1196
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.0651 0.0763
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0103 0.0414
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0221 0.0408
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0004 0.0001
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0103 0.0103
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0269 0.3884
Onchocerca volvulus 0.0035 0.0221 0.0401
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0109
Schistosoma mansoni lozenge 0.0067 0.0556 0.0652
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0048 0.0054
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0076 0.1202
Brugia malayi Bromodomain containing protein 0.0093 0.082 0.1512
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0103 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0279 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.054 0.0994
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0458 0.0539
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0387 0.1348
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1261 1
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0145 0.1196
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.054 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.035 0.1217
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0103 0.0607
Trichomonas vaginalis set domain proteins, putative 0.0288 0.2845 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1261 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0963 0.1784
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0279 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0048 0.0154
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0027 0.0145 0.24
Loa Loa (eye worm) fli-1 protein 0.0265 0.261 0.4834
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0485 0.0891
Brugia malayi mbt repeat family protein 0.0058 0.0458 0.0841
Schistosoma mansoni hypothetical protein 0.0033 0.0202 0.0234
Onchocerca volvulus 0.0288 0.2845 0.5265
Echinococcus multilocularis GPCR, family 2 0.0019 0.0059 0.0059
Brugia malayi CXXC zinc finger family protein 0.0035 0.0221 0.0401
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0279 0.1869
Echinococcus multilocularis expressed protein 0.004 0.0279 0.0279
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0103 0.0414
Leishmania major DNA polymerase eta, putative 0.0023 0.0103 0.0414
Echinococcus granulosus protein quaking 0.0033 0.0202 0.0237
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0628 0.074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0085 0.0286
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0059 0.0069
Onchocerca volvulus 0.0535 0.5399 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8489 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1261 1
Schistosoma mansoni zinc finger protein 0.0018 0.0053 0.0059
Loa Loa (eye worm) pyruvate kinase 0.004 0.0279 0.0516
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0269 0.1792
Brugia malayi Heterochromatin protein 1 0.0084 0.0733 0.135
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0127 0.1368
Schistosoma mansoni chromobox protein 0.0084 0.0733 0.086
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0027 0.0145 0.24
Schistosoma mansoni DNA polymerase eta 0.0023 0.0103 0.0118
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0687 0.1265
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0311 0.0311
Brugia malayi SET domain containing protein 0.0017 0.0039 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0288 0.0525
Echinococcus granulosus cpg binding protein 0.0039 0.0265 0.0312
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0027 0.0145 0.0167
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0085 0.0286
Schistosoma mansoni hypothetical protein 0.0019 0.0059 0.0066
Loa Loa (eye worm) hypothetical protein 0.0085 0.0746 0.1381
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0256 0.0299
Trypanosoma brucei pyruvate kinase 1 0.004 0.0279 0.2033
Brugia malayi Disco-interacting protein 2 homolog 0.0027 0.0145 0.0261
Entamoeba histolytica hypothetical protein 0.0043 0.0311 0.45
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0207 0.0715
Echinococcus granulosus chromobox protein 2 0.0014 0.0004 0.0005
Brugia malayi Muscleblind-like protein 0.018 0.1729 0.3197
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0339 0.04
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0103 0.1446
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0145 0.24
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1261 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1261 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0018 0.0048 0.0057
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1261 1
Echinococcus granulosus disco interacting protein 2 0.0027 0.0145 0.0171
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0311 0.0367
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0767 0.142
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0003 0.0003
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.035 0.0641
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0311 0.0363
Echinococcus multilocularis muscleblind protein 0.018 0.1729 0.1729
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0145 0.24
Loa Loa (eye worm) hypothetical protein 0.003 0.0177 0.0327
Echinococcus granulosus chromobox protein 1 0.0084 0.0733 0.0863
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0119 0.0221
Schistosoma mansoni hypothetical protein 0.0205 0.198 0.233
Trypanosoma brucei unspecified product 0.0023 0.0103 0.0607
Loa Loa (eye worm) hypothetical protein 0.0028 0.0152 0.0282
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0269 0.4459
Brugia malayi Fli-1 protein 0.0265 0.261 0.4831
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0042 0.0293 0.0345
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0687 0.1272
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Echinococcus granulosus pyruvate kinase 0.0021 0.0076 0.0089
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1261 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0103 0.0183
Echinococcus granulosus pyruvate kinase 0.0021 0.0076 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0268
Schistosoma mansoni hypothetical protein 0.0019 0.0059 0.0066
Echinococcus multilocularis pyruvate kinase 0.004 0.0279 0.0279
Schistosoma mansoni SET domain protein 0.0042 0.0293 0.0342
Schistosoma mansoni chromobox protein 0.0014 0.0004 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0103 0.0607
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0076 0.2605
Schistosoma mansoni cpg binding protein 0.0039 0.0265 0.0309
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.2212 0.2212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0469 0.055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0485 0.0898
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0767 0.0767
Echinococcus multilocularis geminin 0.0205 0.198 0.198
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0632
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0279 0.4615
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0269 0.1792
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0059 0.0109
Brugia malayi hypothetical protein 0.0106 0.0963 0.1778
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0152 0.0282
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0007
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.054 0.0637
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.2485 0.4603
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0059 0.0059
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0458 0.0536
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0085 0.0286
Loa Loa (eye worm) hypothetical protein 0.0106 0.0963 0.1784
Echinococcus multilocularis zinc finger protein 0.0026 0.0127 0.0127
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0311 0.0311
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1562 0.1837
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0022 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0103 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0207 0.0715
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0059 0.0101
Brugia malayi hypothetical protein 0.0535 0.5399 1
Loa Loa (eye worm) hypothetical protein 0.0535 0.5399 1
Schistosoma mansoni hypothetical protein 0.0033 0.0202 0.0234
Echinococcus multilocularis Chromo domain 0.0014 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0371 0.0687
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0059 0.0069
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0075 0.0088
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4975 0.4975
Onchocerca volvulus 0.0052 0.0399 0.0732
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0279 0.0517
Echinococcus granulosus pyruvate kinase 0.004 0.0279 0.0328
Echinococcus granulosus dna polymerase eta 0.0023 0.0103 0.0121
Entamoeba histolytica hypothetical protein 0.0043 0.0311 0.45
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.018 0.1729 0.3202
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0018 0.0048 0.0048
Echinococcus granulosus expressed protein 0.004 0.0279 0.0329
Echinococcus multilocularis Protein lozenge 0.0067 0.0556 0.0556
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0103 0.0121
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0042 0.0293 0.0293
Echinococcus multilocularis pyruvate kinase 0.0021 0.0076 0.0076
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0458 0.0458
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1261 1
Schistosoma mansoni hypothetical protein 0.0043 0.0311 0.0363
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.054 0.054
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0767 0.0903
Echinococcus granulosus pyruvate kinase 0.004 0.0279 0.0328
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0059 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Echinococcus granulosus Chromobox protein 3 0.0014 0.0004 0.0005
Schistosoma mansoni phd finger protein 0.0014 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.035 0.3487 0.4105
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0103 0.0348
Brugia malayi Bromodomain containing protein 0.0046 0.034 0.0623
Echinococcus multilocularis cpg binding protein 0.0039 0.0265 0.0265
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0085 0.0286
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0177 0.1026
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0279 0.2033
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0279 0.0966
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0075 0.0085
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0145 0.24
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0145 0.24
Brugia malayi mbt repeat family protein 0.0058 0.0458 0.0841
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0535 0.5399 1
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0076 0.2605
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0687 0.5249
Echinococcus granulosus muscleblind protein 0.018 0.1729 0.2037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0048 0.0154
Schistosoma mansoni pyruvate kinase 0.004 0.0279 0.0325
Plasmodium falciparum pyruvate kinase 0.004 0.0279 1
Echinococcus granulosus peregrin 0.0014 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0202 0.0374
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0279 0.0509
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0085 0.0286
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0177 0.2902
Schistosoma mansoni rotamase 0.004 0.0279 0.0326
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0279 0.0509
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0027 0.0145 0.1196
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.054 0.054
Loa Loa (eye worm) helicase 0.0014 0.0004 0.0007
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0687 0.0809
Chlamydia trachomatis pyruvate kinase 0.004 0.0279 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0075 0.0085
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0164 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Loa Loa (eye worm) hypothetical protein 0.0053 0.0415 0.0769
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0268
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0469 0.0553
Brugia malayi hypothetical protein 0.0033 0.0202 0.0366
Echinococcus multilocularis pyruvate kinase 0.0032 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0059
Echinococcus granulosus dna polymerase kappa 0.0023 0.0103 0.0121
Loa Loa (eye worm) pyruvate kinase 0.004 0.0279 0.0516
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0103 0.0414
Schistosoma mansoni hypothetical protein 0.0041 0.0288 0.0335
Mycobacterium ulcerans pyruvate kinase 0.004 0.0279 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0279 0.051
Entamoeba histolytica hypothetical protein 0.0043 0.0311 0.45
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0687 0.5345
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0164 0.019
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1261 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0103 0.0607
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0145 0.24
Onchocerca volvulus 0.0058 0.0458 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0103 0.0607
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0007
Echinococcus multilocularis chromobox protein 2 0.0014 0.0004 0.0004
Plasmodium vivax pyruvate kinase, putative 0.004 0.0279 1
Trypanosoma brucei ISWI complex protein 0.0018 0.0053 0.0202
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0458 0.0536
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.019
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0177 0.1026
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0103 0.0118
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0687 0.0687
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.1261 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0687 0.5249
Giardia lamblia DINP protein human, muc B family 0.0023 0.0103 0.1341
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0458 0.0841
Schistosoma mansoni hypothetical protein 0.0205 0.198 0.233
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0687 0.5249
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0458 0.0458
Echinococcus granulosus hypothetical protein 0.0033 0.0202 0.0237
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0103 0.0348
Loa Loa (eye worm) MBCTL1 0.0066 0.054 0.1001
Schistosoma mansoni chromobox protein 0.0084 0.0733 0.086
Schistosoma mansoni hypothetical protein 0.0152 0.1435 0.1688
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0733 0.2565
Echinococcus multilocularis chromobox protein 1 0.0084 0.0733 0.0733
Echinococcus granulosus GPCR family 2 0.0019 0.0059 0.0069
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0004 0.0005
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0145 0.1196
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0458 0.0536
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1562 0.1837
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1261 1
Echinococcus granulosus pyruvate kinase 0.0021 0.0076 0.0089
Loa Loa (eye worm) tumor suppressor 0.0388 0.3882 0.719
Echinococcus multilocularis disco interacting protein 2 0.0027 0.0145 0.0145

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 1.72 uM PubChem BioAssay. S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) 11.84 uM PubChem BioAssay. Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (binding) 12.29 uM PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (binding) = 25.949 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of Mex-5 Binding to TCR-2. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
EC50 (binding) > 300 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of POS-1 Binding to mex-3-RNA. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
IC50 (binding) = 4.963 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (binding) = 14.25 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
IC50 (binding) 27.762 uM PubChem BioAssay. Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )]. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) 83.289 uM PubChem BioAssay. Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )]. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5174 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (binding) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.3814 uM PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 58.4789 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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