Detailed information for compound 1364137

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 500.438 | Formula: C22H27Cl2N3O4S
  • H donors: 0 H acceptors: 3 LogP: 3.63 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN1CCN(CC1)S(=O)(=O)c1ccc(c(c1)C(=O)N(CCOc1ccc(cc1)Cl)C)Cl
  • InChi: 1S/C22H27Cl2N3O4S/c1-3-26-10-12-27(13-11-26)32(29,30)19-8-9-21(24)20(16-19)22(28)25(2)14-15-31-18-6-4-17(23)5-7-18/h4-9,16H,3,10-15H2,1-2H3
  • InChiKey: UINMGICZUPYDIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0227 0.1798 0.367
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0056 0.0028 0.0028
Leishmania major protein kinase, putative 0.0151 0.1017 0.5583
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0316 0.2723 0.2723
Trypanosoma brucei cdc2-related kinase 1 0.0113 0.062 0.322
Echinococcus multilocularis mitogen activated protein kinase 11 0.0157 0.1079 0.2203
Echinococcus granulosus protein kinase c epsilon type 0.0168 0.1192 0.2432
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0121 0.0701 0.143
Trichomonas vaginalis AGC family protein kinase 0.0233 0.1867 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0098 0.02
Brugia malayi Protein kinase c protein 2 0.0109 0.0585 0.0585
Trichomonas vaginalis AGC family protein kinase 0.0233 0.1867 1
Brugia malayi Protein kinase domain containing protein 0.0194 0.1463 0.1463
Plasmodium falciparum glycogen synthase kinase 3 0.0071 0.0187 0.1612
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0095 0.0439 0.232
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0113 0.062 0.062
Trypanosoma cruzi casein kinase, delta isoform, putative 0.006 0.0073 0.0256
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0098 0.0261
Brugia malayi Protein kinase domain containing protein 0.0121 0.0701 0.0701
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1019 1 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0439 0.0439
Giardia lamblia Kinase, AGC PKA 0.0124 0.0738 0.4008
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0124 0.0738 0.7179
Echinococcus multilocularis protein kinase c iota type 0.0258 0.2122 0.4331
Echinococcus multilocularis expressed protein 0.0073 0.0213 0.0435
Trypanosoma brucei rac serine-threonine kinase, putative 0.0233 0.1867 1
Schistosoma mansoni protein kinase 0.0157 0.1079 0.2871
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0056 0.0028 0.0028
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0098 0.02
Toxoplasma gondii casein kinase I 0.006 0.0073 0.0257
Toxoplasma gondii AGC kinase 0.0062 0.0098 0.0397
Giardia lamblia Kinase, CMGC GSK 0.0071 0.0187 0.09
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0157 0.1079 0.2202
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.037 0.3284 0.6702
Echinococcus multilocularis nervana 2 0.0106 0.0549 0.112
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0122 0.0718 0.0718
Giardia lamblia Kinase, NEK 0.0132 0.0818 0.4458
Echinococcus multilocularis casein kinase i 0.006 0.0073 0.0149
Brugia malayi Temporarily assigned gene name protein 59 0.0095 0.0439 0.0439
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0157 0.1079 0.2202
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0113 0.062 0.1265
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0073 0.0213 0.1047
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.022 0.1047
Schistosoma mansoni serine/threonine protein kinase 0.034 0.2971 0.7906
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.1799 0.9632
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0945 0.0945
Brugia malayi p70 ribosomal S6 kinase beta 0.0226 0.1797 0.1797
Onchocerca volvulus 0.034 0.2971 0.9026
Echinococcus granulosus serine:threonine protein kinase N2 0.0143 0.093 0.1899
Echinococcus granulosus cyclin dependent kinase 1 0.0113 0.062 0.1265
Trypanosoma cruzi Protein kinase B 0.0131 0.0808 0.4406
Loa Loa (eye worm) hypothetical protein 0.0157 0.1081 0.1081
Loa Loa (eye worm) hypothetical protein 0.0199 0.1511 0.1511
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0706 0.3689
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1017 0.2706
Brugia malayi Protein kinase domain containing protein 0.0151 0.1017 0.1017
Giardia lamblia Kinase, PLK 0.0227 0.1799 1
Plasmodium falciparum serine/threonine protein kinase 0.0073 0.0213 0.1875
Echinococcus multilocularis casein kinase I alpha 0.006 0.0073 0.0149
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0157 0.1079 0.5936
Schistosoma mansoni protein kinase 0.0157 0.1079 0.2871
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0151 0.1011 0.1011
Brugia malayi Protein kinase domain containing protein 0.0476 0.4378 0.4378
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0228 0.1808 0.3691
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.062 0.165
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0227 0.1799 0.3673
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0102 0.0512 0.2632
Trichomonas vaginalis AGC family protein kinase 0.0132 0.0818 0.4294
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0157 0.1079 0.5936
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0236 0.1893 0.3863
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0028 0.0074
Trypanosoma cruzi casein kinase, putative 0.006 0.0073 0.0256
Plasmodium vivax glycogen synthase kinase 3, putative 0.0071 0.0187 0.1612
Plasmodium vivax protein kinase Crk2 0.0113 0.062 0.5987
Echinococcus multilocularis casein kinase I delta 0.006 0.0073 0.0149
Echinococcus multilocularis mitogen activated protein kinase 14 0.0157 0.1079 0.2203
Trichomonas vaginalis AGC family protein kinase 0.0233 0.1867 1
Echinococcus multilocularis rho associated protein kinase 0.034 0.2971 0.6064
Loa Loa (eye worm) AGC/PKA protein kinase 0.0062 0.0098 0.0098
Echinococcus multilocularis cyclin dependent kinase 0.0113 0.062 0.1265
Echinococcus multilocularis cyclin dependent kinase 1 0.0113 0.062 0.1265
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0175 0.1269 0.1269
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0059 0.0068 0.0138
Entamoeba histolytica protein kinase, putative 0.0233 0.1867 1
Echinococcus granulosus protein kinase C gamma type 0.0166 0.1167 0.2381
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.062 0.322
Trypanosoma brucei casein kinase I, isoform 2 0.006 0.0073 0.0247
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0416 0.3758 0.767
Trypanosoma brucei cdc2-related kinase 3 0.0113 0.062 0.322
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0526 0.49 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0062 0.0098 0.0397
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0073 0.0213 0.1008
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0113 0.0628 0.1281
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0098 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0098 0.0261
Brugia malayi putative serine/threonine kinase SADA gamma 0.0056 0.0028 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0187 0.0867
Echinococcus granulosus serine:threonine protein kinase 0.0063 0.0104 0.0213
Onchocerca volvulus 0.0153 0.1034 0.2994
Loa Loa (eye worm) hypothetical protein 0.0131 0.0808 0.0808
Trichomonas vaginalis STE family protein kinase 0.0059 0.0068 0.0217
Giardia lamblia Kinase, CMGC CDK 0.0113 0.062 0.3343
Echinococcus granulosus dual specificity protein kinase clk2 0.0151 0.1017 0.2076
Plasmodium vivax serine/threonine kinase-1, putative 0.0151 0.1017 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0124 0.0738 0.1506
Loa Loa (eye worm) hypothetical protein 0.0095 0.0439 0.0439
Loa Loa (eye worm) AGC/PKN protein kinase 0.0263 0.2178 0.2178
Plasmodium vivax casein kinase 1, putative 0.006 0.0073 0.0459
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0227 0.1799 0.1799
Brugia malayi Protein kinase domain 0.0059 0.0068 0.0068
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0113 0.062 0.3348
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0074 0.022 0.1087
Trypanosoma cruzi cdc2-related kinase 1 0.0113 0.062 0.3343
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1017 0.2706
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0059 0.0068 0.0138
Echinococcus multilocularis Glutaredoxin protein 5 0.0106 0.0549 0.112
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0097 0.0452 0.0923
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0121 0.0701 0.143
Echinococcus multilocularis mitogen activated protein kinase 0.0074 0.022 0.045
Trypanosoma cruzi casein kinase, putative 0.006 0.0073 0.0256
Brugia malayi casein kinase 1, delta 0.006 0.0073 0.0073
Schistosoma mansoni protein kinase 0.0059 0.0068 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0104 0.0416
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0071 0.0187 0.0901
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0701 0.1864
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0194 0.1463 0.1463
Echinococcus granulosus casein kinase i 0.006 0.0073 0.0149
Onchocerca volvulus Serine\/threonine kinase homolog 0.0227 0.1799 0.5377
Leishmania major protein kinase A catalytic subunit 0.0062 0.0098 0.0397
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1657 0.4408
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.0187 0.0867
Leishmania major protein kinase A catalytic subunit isoform 2 0.0062 0.0098 0.0397
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0074 0.022 0.022
Giardia lamblia Kinase, CMGC CLK 0.0151 0.1017 0.5583
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0095 0.0439 0.232
Trichomonas vaginalis STE family protein kinase 0.0059 0.0068 0.0217
Trypanosoma cruzi cdc2-related kinase 1 0.0113 0.062 0.3343
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0075 0.0231 0.1105
Entamoeba histolytica serine/threonine protein kinase, putative 0.0227 0.1799 0.9632
Giardia lamblia Kinase, STE STE20 0.0075 0.0231 0.1147
Loa Loa (eye worm) hypothetical protein 0.0228 0.1808 0.1808
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0073 0.0247
Loa Loa (eye worm) hypothetical protein 0.009 0.0381 0.0381
Trichomonas vaginalis AGC family protein kinase 0.0233 0.1867 1
Brugia malayi MH2 domain containing protein 0.0144 0.0945 0.0945
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0028 0.0074
Loa Loa (eye worm) hypothetical protein 0.0133 0.0828 0.0828
Loa Loa (eye worm) AGC/NDR protein kinase 0.0121 0.0701 0.0701
Onchocerca volvulus 0.0322 0.2782 0.8438
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0236 0.1893 0.1893
Brugia malayi hypothetical protein 0.0095 0.0439 0.0439
Giardia lamblia Kinase, NEK 0.0132 0.0818 0.4458
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0062 0.0098 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.1799 0.9632
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.1192 0.3171
Schistosoma mansoni serine/threonine kinase 0.0121 0.0701 0.1864
Schistosoma mansoni protein kinase 0.006 0.0073 0.0194
Brugia malayi protein kinase C II. 0.0168 0.1192 0.1192
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0168 0.0765
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.062 0.322
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0226 0.1797 0.1797
Echinococcus multilocularis serine:threonine protein kinase 3 0.0265 0.2193 0.4475
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0074 0.022 0.1087
Echinococcus multilocularis geminin 0.0205 0.1571 0.3206
Giardia lamblia Kinase, CMGC MAPK 0.0074 0.022 0.1087
Echinococcus granulosus mitogen activated protein kinase 11 0.0157 0.1079 0.2203
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0071 0.0187 0.09
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0073 0.0247
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0131 0.0808 0.4406
Entamoeba histolytica casein kinase 1, putative 0.006 0.0073 0.0247
Loa Loa (eye worm) hypothetical protein 0.0056 0.0028 0.0028
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0222 0.1746 0.1746
Loa Loa (eye worm) hypothetical protein 0.0063 0.0104 0.0104
Echinococcus multilocularis rac serine:threonine kinase 0.0131 0.0808 0.165
Echinococcus granulosus serine:threonine protein kinase N2 0.0263 0.2178 0.4445
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.2178 0.5796
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0121 0.0701 0.143
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0213 0.0567
Brugia malayi Fes/CIP4 homology domain containing protein 0.0079 0.0271 0.0271
Echinococcus granulosus Glutaredoxin protein 5 0.0106 0.0549 0.112
Trypanosoma cruzi polo-like protein kinase, putative 0.0227 0.1799 1
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0132 0.0818 0.4465
Trypanosoma cruzi casein kinase, putative 0.006 0.0073 0.0256
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0222 0.1746 0.1746
Echinococcus granulosus protein kinase 0.0151 0.1011 0.2064
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0203 0.1554 0.1554
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0907 0.2413
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0227 0.1799 1
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.022 0.1047
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.006 0.0073 0.0073
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.0187 0.0867
Echinococcus multilocularis serine:threonine protein kinase N2 0.0121 0.0701 0.143
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0416 0.3758 0.767
Brugia malayi intracellular kinase 0.0071 0.0187 0.0187
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0075 0.0231 0.1147
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0056 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0205 0.1571 0.418
Brugia malayi Protein kinase domain containing protein 0.0113 0.062 0.062
Schistosoma mansoni serine/threonine-protein kinase 0.0131 0.0808 0.2151
Echinococcus granulosus casein kinase I alpha 0.006 0.0073 0.0149
Trypanosoma cruzi cdc2-related kinase 3 0.0113 0.062 0.3343
Brugia malayi Protein kinase domain containing protein 0.0203 0.1554 0.1554
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0124 0.0738 0.7179
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0121 0.0701 0.0701
Echinococcus multilocularis serine:threonine protein kinase 0.0063 0.0104 0.0213
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0062 0.0098 0.0382
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0121 0.0701 0.143
Brugia malayi map kinase activated protein kinase protein 2 0.0416 0.3758 0.3758
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0071 0.0187 0.0187
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0227 0.1798 0.367
Brugia malayi Hr1 repeat family protein 0.0263 0.2178 0.2178
Entamoeba histolytica PH domain containing protein kinase, putative 0.0131 0.0808 0.4244
Echinococcus granulosus cyclin dependent kinase 5 0.0113 0.062 0.1265
Brugia malayi Temporarily assigned gene name protein 59 0.0142 0.0923 0.0923
Echinococcus granulosus serine:threonine protein kinase 3 0.0265 0.2193 0.4475
Schistosoma mansoni protein kinase 0.0151 0.1011 0.2691
Echinococcus granulosus mitogen activated protein kinase 3 0.0074 0.022 0.045
Echinococcus multilocularis mitogen activated protein kinase 14 0.0157 0.1079 0.2203
Plasmodium falciparum NIMA related kinase 1 0.0132 0.0818 0.7985
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0095 0.0439 0.0895
Schistosoma mansoni protein kinase 0.0059 0.0068 0.018
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0056 0.0028 0.0056
Echinococcus granulosus protein kinase shaggy 0.0071 0.0187 0.0382
Brugia malayi casein kinase I 0.006 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0273 0.2282 0.2282
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0151 0.1017 0.5583
Giardia lamblia Kinase, CMGC GSK 0.0071 0.0187 0.09
Loa Loa (eye worm) hypothetical protein 0.0508 0.4711 0.4711
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0059 0.0068 0.0138
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0121 0.0701 0.143
Trypanosoma cruzi polo-like protein kinase, putative 0.0227 0.1799 1
Echinococcus granulosus hypothetical protein 0.0133 0.0828 0.169
Trichomonas vaginalis AGC family protein kinase 0.0233 0.1867 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0074 0.022 0.1087
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.1799 0.9632
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0097 0.0452 0.0923
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0945 0.0945
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0187 0.0867
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0213 0.1657 0.3381
Echinococcus granulosus serine:threonine protein kinase 0.0063 0.0104 0.0213
Schistosoma mansoni hypothetical protein 0.0095 0.0439 0.1167
Plasmodium falciparum protein kinase 5 0.0113 0.062 0.5987
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0059 0.0068 0.0138
Entamoeba histolytica cell division protein kinase 2, putative 0.0113 0.062 0.322
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0113 0.062 0.3343
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0168 0.1192 0.1192
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0122 0.0718 0.0718
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0151 0.1017 0.5378
Trypanosoma brucei protein kinase, putative 0.0071 0.0187 0.0867
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.062 0.165
Echinococcus multilocularis myosin iiia 0.0075 0.0231 0.0471
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0168 0.0765
Trypanosoma brucei polo-like protein kinase 0.0227 0.1799 0.9632
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0056 0.0028 0.0056
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0701 0.3658
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0062 0.0098 0.0397
Loa Loa (eye worm) AGC/AKT protein kinase 0.0233 0.1867 0.1867
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.1799 0.9632
Echinococcus multilocularis cyclin dependent kinase 1 0.0113 0.062 0.1265
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.1799 0.9632
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0157 0.1079 0.1079
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0151 0.1017 0.5583
Echinococcus granulosus NDR protein kinase 0.0121 0.0701 0.143
Brugia malayi probable protein kinase 0.0246 0.1997 0.1997
Brugia malayi Protein kinase domain containing protein 0.0236 0.1893 0.1893
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0124 0.0738 0.4008
Brugia malayi Protein kinase domain containing protein 0.0195 0.1474 0.1474
Loa Loa (eye worm) hypothetical protein 0.021 0.1628 0.1628
Echinococcus multilocularis serine:threonine protein kinase 38 0.0121 0.0701 0.143
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0213 0.1657 0.3381
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0071 0.0187 0.0382
Echinococcus granulosus protein kinase c iota type 0.0258 0.2122 0.4331
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1657 0.4408
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.1017 0.5378
Brugia malayi Protein kinase domain containing protein 0.0063 0.0104 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.022 0.1047
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0095 0.0439 0.1167
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0071 0.0187 0.0498
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1554 0.4135
Echinococcus multilocularis serine:threonine protein kinase N2 0.0143 0.093 0.1899
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0028 0.0074
Echinococcus granulosus casein kinase I delta 0.006 0.0073 0.0149
Loa Loa (eye worm) hypothetical protein 0.0062 0.0098 0.0098
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0162 0.1132 0.1132
Echinococcus multilocularis cyclin dependent kinase 5 0.0113 0.062 0.1265
Onchocerca volvulus 0.0203 0.1557 0.4622
Entamoeba histolytica casein kinase, putative 0.006 0.0073 0.0247
Echinococcus granulosus cyclin dependent kinase 0.0113 0.062 0.1265
Entamoeba histolytica PH domain containing protein kinase, putative 0.0131 0.0808 0.4244
Brugia malayi Protein kinase domain containing protein 0.0121 0.0701 0.0701
Entamoeba histolytica protein kinase, putative 0.0226 0.1797 0.9617
Echinococcus granulosus geminin 0.0205 0.1571 0.3206
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0236 0.1893 0.3863
Trypanosoma brucei protein kinase, putative 0.0074 0.022 0.1047
Schistosoma mansoni vam6/vps39 related 0.0095 0.0439 0.1167
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0124 0.0738 0.1506
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.062 0.322
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0265 0.2193 0.2193
Schistosoma mansoni serine/threonine protein kinase 0.037 0.3284 0.8738
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0062 0.0098 0.0382
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.1799 0.4788
Schistosoma mansoni rap gtpase-activating protein 0.0095 0.0439 0.1167
Brugia malayi STE20-like kinase MST 0.0265 0.2193 0.2193
Onchocerca volvulus 0.021 0.1628 0.4842
Schistosoma mansoni protein kinase 0.0236 0.1893 0.5036
Trypanosoma cruzi casein kinase, putative 0.006 0.0073 0.0256
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0073 0.0213 0.1047
Entamoeba histolytica protein kinase, putative 0.0073 0.0213 0.1008
Schistosoma mansoni protein kinase C mu 0.0222 0.1746 0.4646
Echinococcus multilocularis protein kinase shaggy 0.0071 0.0187 0.0382
Loa Loa (eye worm) hypothetical protein 0.0153 0.1034 0.1034
Echinococcus granulosus rho-associated protein kinase 1 0.034 0.2971 0.6064
Schistosoma mansoni kinase 0.0124 0.0735 0.1955
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0056 0.0028 0.0056
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0476 0.4378 0.4378
Loa Loa (eye worm) hypothetical protein 0.0157 0.1081 0.1081
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0098 0.02
Entamoeba histolytica protein kinase, putative 0.0233 0.1867 1
Onchocerca volvulus 0.0157 0.1081 0.3138
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0098 0.02
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.037 0.3284 1
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0701 0.3658
Entamoeba histolytica protein kinase, putative 0.0073 0.0213 0.1008
Giardia lamblia Kinase, NEK 0.0132 0.0818 0.4458
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0157 0.1079 0.5936
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0151 0.1017 0.1017
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0098 0.02
Leishmania major protein kinase, putative 0.0151 0.1017 0.5583
Loa Loa (eye worm) hypothetical protein 0.0203 0.1557 0.1557
Plasmodium falciparum protein serine/threonine kinase-1 0.0151 0.1017 1
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0075 0.0231 0.1147
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0074 0.022 0.1087
Trichomonas vaginalis AGC family protein kinase 0.0062 0.0098 0.0382
Entamoeba histolytica p21-activated kinase 0.0066 0.0138 0.0601
Echinococcus multilocularis casein kinase I alpha 0.006 0.0073 0.0149
Echinococcus granulosus nervana 2 0.0106 0.0549 0.112
Brugia malayi hypothetical protein 0.0227 0.1798 0.1798
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0097 0.0452 0.0923
Onchocerca volvulus 0.0071 0.0187 0.0355
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0071 0.0189 0.0914
Toxoplasma gondii AGC kinase 0.0062 0.0098 0.0397
Echinococcus granulosus mitogen activated protein kinase 14 0.0157 0.1079 0.2203
Onchocerca volvulus 0.0095 0.0439 0.1139
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0063 0.0104 0.0104
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.1798 0.4785
Loa Loa (eye worm) hypothetical protein 0.0095 0.0439 0.0439
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0071 0.0187 0.09
Schistosoma mansoni protein kinase 0.0246 0.1997 0.5314
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0062 0.0098 0.0098
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0059 0.0068 0.0138
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0121 0.0701 0.143
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0106 0.0549 0.112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.022 0.1087
Trypanosoma cruzi cdc2-related kinase 3 0.0113 0.062 0.3343
Brugia malayi Serine/threonine-protein kinase SULU 0.0227 0.1798 0.1798
Schistosoma mansoni ste20-related kinase 0.0208 0.1604 0.4267
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.1643 0.4373
Entamoeba histolytica protein kinase 2, putative 0.0124 0.0738 0.386
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0097 0.0452 0.0923
Schistosoma mansoni protein kinase 0.0194 0.1463 0.3894
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.022 0.0586
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0098 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.1643 0.4373
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0095 0.0439 0.0895
Entamoeba histolytica cell division protein kinase 2, putative 0.0113 0.062 0.322
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.1799 0.9632
Brugia malayi Serine/threonine-protein kinase Pim-3 0.037 0.3284 0.3284
Brugia malayi P38 map kinase family protein 2 0.0157 0.1079 0.1079
Echinococcus granulosus Vam6:Vps39 protein 0.0095 0.0439 0.0895
Echinococcus granulosus mitogen activated protein kinase 0.0074 0.022 0.045
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0071 0.0189 0.1634
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0095 0.0439 0.2235
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0059 0.0068 0.0138
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0121 0.0701 0.0701
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0151 0.1017 0.5583
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0028 0.0074
Echinococcus multilocularis mitogen activated protein kinase 3 0.0074 0.022 0.045
Trypanosoma cruzi casein kinase, putative 0.006 0.0073 0.0256
Loa Loa (eye worm) AGC/PKA protein kinase 0.0062 0.0098 0.0098
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0151 0.1017 0.5583
Trichomonas vaginalis AGC family protein kinase 0.0233 0.1867 1
Trichomonas vaginalis CAMK family protein kinase 0.0227 0.1799 0.9632
Brugia malayi protein kinase C3,putative 0.0156 0.1063 0.1063
Brugia malayi cell division control protein 2 homolog 0.0113 0.062 0.062
Echinococcus multilocularis serine:threonine protein kinase 0.0063 0.0104 0.0213
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0157 0.1079 0.5718
Plasmodium falciparum casein kinase 1 0.006 0.0073 0.0459
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0526 0.49 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0106 0.0549 0.112
Giardia lamblia Kinase, STE STE20 0.0059 0.0068 0.0225
Loa Loa (eye worm) hypothetical protein 0.0153 0.1034 0.1034
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0113 0.062 0.062
Echinococcus multilocularis 0.0133 0.0828 0.169
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0095 0.0439 0.1167
Brugia malayi serine/threonine-protein kinase plk-2 0.0227 0.1799 0.1799
Echinococcus granulosus casein kinase I alpha 0.006 0.0073 0.0149
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0227 0.1798 0.1798
Echinococcus granulosus serine/threonine protein kinase 0.0131 0.0808 0.165
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0132 0.0818 0.7985
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0062 0.0098 0.0397
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0073 0.0073
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0416 0.3758 0.3758
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0452 0.1204
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0151 0.1017 0.5592
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0212 0.1643 0.3354
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0062 0.0098 0.0382
Echinococcus multilocularis nervana 2 0.0106 0.0549 0.112
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.022 0.1047
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0071 0.0187 0.0187
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0063 0.0108 0.0108
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0062 0.0098 0.0397
Loa Loa (eye worm) hypothetical protein 0.0095 0.0431 0.0431
Giardia lamblia Kinase, AGC PKA 0.0062 0.0098 0.0397
Entamoeba histolytica protein kinase, putative 0.0121 0.0701 0.3658
Schistosoma mansoni serine/threonine-protein kinase 0.0131 0.0808 0.2151
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0073 0.0213 0.1049
Echinococcus granulosus serine threonine protein kinase nrc 0.0124 0.0738 0.1506
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0073 0.0247
Schistosoma mansoni hypothetical protein 0.0205 0.1571 0.418
Echinococcus granulosus nervana 2 0.0106 0.0549 0.112
Loa Loa (eye worm) hypothetical protein 0.0153 0.1034 0.1034
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.022 0.1087
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0706 0.3689
Echinococcus granulosus casein kinase I alpha 0.006 0.0073 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0028 0.0074
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0074 0.022 0.1089
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0073 0.0194
Leishmania major protein kinase A catalytic subunit isoform 1 0.0062 0.0098 0.0397
Schistosoma mansoni atypical protein kinase C 0.0265 0.2191 0.5831
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0062 0.0098 0.071
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0771 0.4042
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0073 0.0213 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0701 0.1864
Brugia malayi Protein kinase domain containing protein 0.037 0.3284 0.3284
Trichomonas vaginalis STE family protein kinase 0.0132 0.0818 0.4294
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0098 0.0261
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0113 0.0628 0.1281
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0113 0.062 0.062
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0074 0.022 0.1047
Leishmania major casein kinase, putative 0.006 0.0073 0.0256
Toxoplasma gondii AGC kinase 0.0226 0.1797 1
Echinococcus granulosus expressed protein 0.0073 0.0213 0.0435
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0701 0.1864
Entamoeba histolytica protein kinase, putative 0.0071 0.0187 0.0867
Schistosoma mansoni serine/threonine protein kinase 0.0416 0.3758 1
Trichomonas vaginalis STE family protein kinase 0.0075 0.0231 0.1105
Loa Loa (eye worm) thyroid receptor interactor 0.0079 0.0271 0.0271
Giardia lamblia Kinase, CK1 Casein kinase 0.006 0.0073 0.0256
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0071 0.0187 0.0382
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0148 0.0985 0.0985
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0113 0.062 0.3343
Echinococcus multilocularis serine threonine protein kinase 0.0166 0.1167 0.2381
Echinococcus multilocularis casein kinase I delta 0.006 0.0073 0.0149
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0151 0.1017 0.5378
Echinococcus multilocularis casein kinase I alpha 0.006 0.0073 0.0149
Plasmodium vivax serine/threonine protein kinase, putative 0.0073 0.0213 0.1875
Echinococcus multilocularis protein kinase c epsilon type 0.0168 0.1192 0.2432
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0073 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0452 0.1204
Loa Loa (eye worm) CAMK/PIM protein kinase 0.037 0.3284 0.3284
Echinococcus granulosus Protein kinase C brain isozyme 0.0212 0.1643 0.3354
Brugia malayi Doublecortin family protein 0.0148 0.0985 0.0985
Brugia malayi Protein kinase domain containing protein 0.0073 0.0213 0.0213
Trichomonas vaginalis STE family protein kinase 0.0059 0.0068 0.0217
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0227 0.1799 0.3673
Giardia lamblia Kinase, CMGC SRPK 0.0073 0.0213 0.1047
Trichomonas vaginalis STE family protein kinase 0.0059 0.0068 0.0217
Echinococcus granulosus casein kinase I delta 0.006 0.0073 0.0149
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0075 0.0231 0.1105
Giardia lamblia Kinase, CMGC CDK 0.0113 0.062 0.3343
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0701 0.3658
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.037 0.3284 0.6702
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0062 0.0098 0.071
Echinococcus granulosus serine:threonine kinase SAD 1 0.0056 0.0028 0.0056
Echinococcus multilocularis serine:threonine protein kinase N2 0.0263 0.2178 0.4445
Echinococcus multilocularis dual specificity protein kinase clk2 0.0151 0.1017 0.2076
Trichomonas vaginalis AGC family protein kinase 0.0233 0.1867 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0071 0.0189 0.1634
Brugia malayi MAP kinase sur-1 0.0074 0.022 0.022
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0075 0.0231 0.1105
Echinococcus multilocularis 0.0151 0.1011 0.2064
Loa Loa (eye worm) CAMK/PIM protein kinase 0.037 0.3284 0.3284
Echinococcus multilocularis mitogen activated protein kinase 11 0.0157 0.1079 0.2203
Entamoeba histolytica protein kinase, putative 0.0059 0.0068 0.0217
Leishmania major protein kinase, putative 0.0075 0.0231 0.1147
Brugia malayi C1-like domain containing protein 0.0222 0.1746 0.1746
Brugia malayi Protein kinase domain containing protein 0.0233 0.1867 0.1867
Schistosoma mansoni protein kinase 0.0157 0.1079 0.2871

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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