Detailed information for compound 1368074

Basic information

Technical information
  • TDR Targets ID: 1368074
  • Name: 2-[(2-chlorophenyl)methylsulfanyl]-4-(dimetho xymethyl)pyrimidine
  • MW: 310.799 | Formula: C14H15ClN2O2S
  • H donors: 0 H acceptors: 2 LogP: 2.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(c1ccnc(n1)SCc1ccccc1Cl)OC
  • InChi: 1S/C14H15ClN2O2S/c1-18-13(19-2)12-7-8-16-14(17-12)20-9-10-5-3-4-6-11(10)15/h3-8,13H,9H2,1-2H3
  • InChiKey: SOLPVNBNYVMXOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-chlorophenyl)methylthio]-4-(dimethoxymethyl)pyrimidine
  • 2-[(2-chlorobenzyl)thio]-4-(dimethoxymethyl)pyrimidine
  • MLS000833972
  • IDI1_018718
  • Maybridge3_007331
  • SMR000461491
  • ZINC00123373

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0089 0.0601 0.2159
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0045 0.0272 0.4531
Brugia malayi Intermediate filament tail domain containing protein 0.0069 0.045 0.045
Echinococcus multilocularis rho associated protein kinase 0.0437 0.3184 0.3245
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.124 0.3896
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0014 0.0044 0.0045
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0089 0.0601 1
Schistosoma mansoni DNA helicase recq5 0.0012 0.0028 0.0089
Loa Loa (eye worm) hypothetical protein 0.0057 0.0363 0.0363
Plasmodium falciparum cysteine proteinase falcipain 3 0.0014 0.0044 0.1531
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0098 0.1635
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trypanosoma brucei PAB1-binding protein , putative 0.0041 0.0246 0.41
Schistosoma mansoni atypical protein kinase C 0.003 0.0162 0.051
Brugia malayi hypothetical protein 0.003 0.0165 0.0165
Onchocerca volvulus 0.0116 0.0802 0.2519
Loa Loa (eye worm) AGC/PKG protein kinase 0.0042 0.0254 0.0254
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0045 0.0272 0.4531
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0122 0.2024
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0366 0.177
Loa Loa (eye worm) hypothetical protein 0.0146 0.1024 0.1024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0356 0.2583 0.2583
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0044 0.074
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0053 0.0332 0.1044
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0014 0.0044 0.1531
Schistosoma mansoni intermediate filament proteins 0.0069 0.045 0.1415
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0049 0.0814
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0045 0.0272 0.7447
Trichomonas vaginalis AGC family protein kinase 0.005 0.0314 0.1519
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0149 0.1048 0.2515
Echinococcus multilocularis lamin 0.0069 0.045 0.0459
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0187 0.0191
Echinococcus multilocularis dna polymerase eta 0.0021 0.0098 0.01
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.124 0.1264
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0089 0.0601 1
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Onchocerca volvulus 0.0437 0.3184 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0098 0.0098
Onchocerca volvulus 0.0014 0.0044 0.014
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.003 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0188 0.1334 0.4189
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0028 0.0028
Onchocerca volvulus 0.0014 0.0044 0.014
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.001
Onchocerca volvulus 0.0014 0.0044 0.014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0049 0.0305 0.5076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Brugia malayi N-terminal motif family protein 0.0157 0.1108 0.1108
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0286 0.2065 0.2065
Leishmania major cathepsin L-like protease 0.0014 0.0044 0.074
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0028 0.0775
Mycobacterium ulcerans hypothetical protein 0.004 0.0238 0.7165
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0042 0.0254 0.6955
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0044 0.014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0122 0.0122
Toxoplasma gondii LsmAD domain-containing protein 0.0041 0.0246 0.6737
Schistosoma mansoni serine/threonine protein kinase 0.0437 0.3184 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0054 0.0264
Loa Loa (eye worm) hypothetical protein 0.0157 0.1108 0.1108
Brugia malayi Cathepsin L-like precursor 0.0014 0.0044 0.0044
Brugia malayi protein kinase C II. 0.003 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0057 0.0363 0.1139
Onchocerca volvulus 0.0069 0.045 0.1415
Echinococcus multilocularis serine threonine protein kinase 0.003 0.0162 0.0166
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0322 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0044 0.0044
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0089 0.0601 0.0612
Echinococcus granulosus ubiquitin specific protease 41 0.0089 0.0601 0.1441
Echinococcus granulosus cGMP dependent protein kinase 1 0.0042 0.0254 0.061
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0279 0.8377
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus granulosus snurportin 1 0.0356 0.2583 0.6196
Echinococcus granulosus mitogen activated protein kinase 0.0045 0.0272 0.0653
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.003 0.0162 0.039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Echinococcus multilocularis lamin dm0 0.0069 0.045 0.0459
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0098 0.1635
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0098 0.0308
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0098 0.0236
Schistosoma mansoni hypothetical protein 0.003 0.0165 0.0519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0162 0.1145 0.1145
Echinococcus granulosus lamin dm0 0.0069 0.045 0.1081
Echinococcus granulosus serine/threonine protein kinase 0.0029 0.0158 0.038
Echinococcus granulosus cathepsin L cysteine proteinase 0.0014 0.0044 0.0107
Entamoeba histolytica cysteine protease, putative 0.0014 0.0044 0.0127
Giardia lamblia Kinase, CMGC MAPK 0.0045 0.0272 0.4531
Loa Loa (eye worm) MBCTL1 0.0043 0.026 0.026
Leishmania major importin beta-1 subunit, putative 0.0027 0.014 0.2333
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0022 0.0106 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0366 0.177
Schistosoma mansoni serine/threonine kinase 0.003 0.0162 0.051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0089 0.0601 0.2909
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0042 0.0254 0.0259
Echinococcus granulosus lamin 0.0069 0.045 0.1081
Echinococcus multilocularis Glutaredoxin protein 5 0.0027 0.0142 0.0145
Leishmania major hypothetical protein, conserved 0.0041 0.0246 0.41
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0221
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0014 0.0044 0.0045
Echinococcus granulosus geminin 0.0188 0.1334 0.32
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0279 0.8377
Echinococcus granulosus protein kinase C gamma type 0.003 0.0162 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0272 0.1318
Loa Loa (eye worm) hypothetical protein 0.0069 0.045 0.045
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0038 0.0641
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0162 0.1145 0.3597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Onchocerca volvulus Glucosylceramidase homolog 0.0188 0.1334 0.4189
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0089 0.0601 0.1887
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0045 0.0272 0.4531
Plasmodium vivax importin-beta 2, putative 0.0033 0.0187 0.5807
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0322 0.8808
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.0158 0.0497
Schistosoma mansoni ferritin 0.0017 0.0062 0.0195
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0027 0.0142 0.0145
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.0038 0.0641
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Leishmania major cathepsin L-like protease 0.0014 0.0044 0.074
Loa Loa (eye worm) AGC/NDR protein kinase 0.003 0.0162 0.0162
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0279 0.9602
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0054 0.0907
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1334 0.646
Echinococcus granulosus GPCR family 2 0.0057 0.0363 0.087
Trypanosoma brucei protein kinase, putative 0.0045 0.0272 0.4531
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Schistosoma mansoni hypothetical protein 0.0116 0.0802 0.2519
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Onchocerca volvulus 0.0014 0.0044 0.014
Loa Loa (eye worm) hypothetical protein 0.0162 0.1145 0.1145
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0028 0.0029
Schistosoma mansoni peptidase 0.0009 0.0009 0.0028
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0038 0.0641
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0089 0.0601 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0089 0.0601 0.0601
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.0038 0.0039
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0279 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0098 0.0323
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0062 0.2233
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0322 0.0772
Echinococcus multilocularis serine:threonine protein kinase N2 0.003 0.0162 0.0166
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.003 0.0162 0.039
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Entamoeba histolytica protein kinase, putative 0.0057 0.0366 0.13
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.034 0.5655
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0054 0.0907
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0272 0.0855
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.034 0.5655
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Giardia lamblia DINP protein human, muc B family 0.0021 0.0098 0.1635
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0045 0.0272 0.4531
Echinococcus granulosus protein kinase c epsilon type 0.003 0.0162 0.039
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0098 0.01
Echinococcus multilocularis L aminoadipate semialdehyde 0.0162 0.1145 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Onchocerca volvulus 0.0014 0.0044 0.014
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0089 0.0601 0.1441
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0279 0.4637
Schistosoma mansoni ferritin light chain 0.0017 0.0062 0.0195
Brugia malayi p70 ribosomal S6 kinase beta 0.0057 0.0366 0.0366
Loa Loa (eye worm) AGC/PKN protein kinase 0.003 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0089 0.0601 0.0601
Schistosoma mansoni hypothetical protein 0.0057 0.0363 0.1139
Onchocerca volvulus 0.0434 0.3168 0.995
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0158 0.0543
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.029 0.1024
Echinococcus granulosus cathepsin l1 0.0014 0.0044 0.0107
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trypanosoma brucei unspecified product 0.0021 0.0098 0.1635
Schistosoma mansoni ferritin 0.0017 0.0062 0.0195
Leishmania major DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0038 0.0221 0.0694
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.014 0.0679
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0162 0.051
Entamoeba histolytica hypothetical protein 0.0027 0.014 0.0476
Echinococcus granulosus L aminoadipate semialdehyde 0.0162 0.1145 0.2748
Brugia malayi Cathepsin L-like precursor 0.0014 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0286 0.2065 1
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Leishmania major GTP-binding protein, putative 0.0025 0.0122 0.2024
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0272 0.1318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0089 0.0601 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.011 0.0344
Brugia malayi Isocitrate dehydrogenase 0.0013 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus multilocularis cathepsin L cysteine protease 0.0014 0.0044 0.0045
Echinococcus granulosus polycomb protein SCMH1 0.0038 0.0221 0.053
Echinococcus multilocularis cathepsin L cysteine protease 0.0014 0.0044 0.0045
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0165 0.0519
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0069 0.045 0.045
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0155 0.075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.001 0.0047
Echinococcus multilocularis cysteine protease 0.0014 0.0044 0.0045
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0027 0.0142 0.0342
Brugia malayi hypothetical protein 0.0569 0.4168 0.4168
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0272 0.1318
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0177
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0085 0.2642
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.003 0.0162 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Loa Loa (eye worm) hypothetical protein 0.018 0.1278 0.1278
Echinococcus multilocularis serine:threonine protein kinase 38 0.003 0.0162 0.0166
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0122 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0162 0.051
Loa Loa (eye worm) AGC/AKT protein kinase 0.0057 0.0366 0.0366
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0089 0.0601 0.1887
Echinococcus granulosus mitogen activated protein kinase 3 0.0045 0.0272 0.0653
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0049 0.0814
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0045 0.0272 0.4531
Leishmania major cathepsin L-like protease 0.0014 0.0044 0.074
Trypanosoma cruzi PAB1-binding protein , putative 0.0041 0.0246 0.41
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus multilocularis geminin 0.0188 0.1334 0.1359
Schistosoma mansoni hypothetical protein 0.023 0.165 0.5183
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0366 0.177
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0045 0.0272 0.0272
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0022 0.0106 0.0515
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0053 0.0332 1
Brugia malayi Latrophilin receptor protein 2 0.0057 0.0363 0.0363
Brugia malayi MAP kinase sur-1 0.0045 0.0272 0.0272
Echinococcus multilocularis ferritin 0.0017 0.0062 0.0063
Leishmania major protein kinase, putative 0.001 0.0016 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Schistosoma mansoni ran 0.0025 0.0122 0.0382
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0054 0.0164
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0038 0.0221 0.0694
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0122 0.2024
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.0158 0.0497
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0279 1
Onchocerca volvulus 0.0162 0.1145 0.3597
Brugia malayi Cathepsin L-like cysteine proteinase 0.0009 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0366 0.177
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0043 0.026 0.026
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0028 0.0775
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0098 0.2953
Brugia malayi Cathepsin L-like precursor 0.0009 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0157 0.1108 0.3481
Echinococcus multilocularis serine:threonine protein kinase N2 0.003 0.0162 0.0166
Brugia malayi RNA, U transporter 1 0.0095 0.0643 0.0643
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1334 0.646
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0089 0.0601 0.2909
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0098 0.0098
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0045 0.0275 0.0275
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Trichomonas vaginalis glucosylceramidase, putative 0.0286 0.2065 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0057 0.0366 0.0366
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0045 0.0272 0.4531
Schistosoma mansoni hypothetical protein 0.0356 0.2583 0.8111
Echinococcus granulosus dna polymerase kappa 0.0021 0.0098 0.0236
Echinococcus granulosus protein kinase c iota type 0.003 0.0162 0.039
Trichomonas vaginalis glucosylceramidase, putative 0.0286 0.2065 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0279 0.8651
Toxoplasma gondii AGC kinase 0.0057 0.0366 1
Schistosoma mansoni hypothetical protein 0.0188 0.1334 0.4189
Echinococcus granulosus importin subunit beta 1 0.0033 0.0187 0.0449
Loa Loa (eye worm) cysteine protease 0.0014 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0569 0.4168 0.4168
Loa Loa (eye worm) ctsf protein 0.0014 0.0044 0.0044
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.003 0.0162 0.0162
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Entamoeba histolytica protein kinase, putative 0.0057 0.0366 0.13
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.0221 0.0694
Echinococcus granulosus serine:threonine protein kinase N2 0.003 0.0162 0.039
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0054 0.0907
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.003 0.0162 0.0166
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0089 0.0601 0.0612
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0279 0.4637
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0098 0.2953
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0149 0.1048 0.1069
Echinococcus multilocularis protein kinase c epsilon type 0.003 0.0162 0.0166
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0019 0.0077 0.0078
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0033 0.0186 0.019
Echinococcus granulosus cathepsin l cysteine peptidase 0.0014 0.0044 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1334 0.646
Leishmania major cathepsin L-like protease 0.0014 0.0044 0.074
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0322 0.1559
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0332 0.0332
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0098 0.1635
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0089 0.0601 0.1441
Echinococcus multilocularis SAM and MBT domain containing protein 0.0038 0.0221 0.0225
Leishmania major DNA polymerase eta, putative 0.0021 0.0098 0.1635
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Entamoeba histolytica hypothetical protein 0.003 0.0165 0.0568
Trichomonas vaginalis glucosylceramidase, putative 0.0286 0.2065 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0322 0.8808
Echinococcus multilocularis polycomb protein SCMH1 0.0038 0.0221 0.0225
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.029 0.4829
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0045 0.0272 0.4531
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0098 0.2953
Entamoeba histolytica hypothetical protein 0.003 0.0165 0.0568
Onchocerca volvulus Cathepsin L homolog 0.0014 0.0044 0.014
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0122 0.2024
Entamoeba histolytica hypothetical protein 0.003 0.0165 0.0568
Schistosoma mansoni hypothetical protein 0.0057 0.0363 0.1139
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0048 0.0298 0.1441
Trypanosoma brucei rac serine-threonine kinase, putative 0.0057 0.0366 0.6085
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0122 0.2024
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0042 0.0254 0.0259
Schistosoma mansoni ferritin 0.0017 0.0062 0.0195
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0044 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Echinococcus granulosus SAM and MBT domain containing protein 0.0038 0.0221 0.053
Entamoeba histolytica protein kinase, putative 0.003 0.0162 0.0558
Echinococcus multilocularis GPCR, family 2 0.0057 0.0363 0.037
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0062 0.187
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0062 0.187
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0155 0.0155
Echinococcus granulosus cGMP dependent protein kinase 1 0.0042 0.0254 0.061
Brugia malayi Cathepsin L-like precursor 0.0014 0.0044 0.0044
Schistosoma mansoni importin beta-1 0.0033 0.0187 0.0587
Leishmania major cysteine peptidase A (CPA) 0.0014 0.0044 0.074
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1334 0.646
Trypanosoma cruzi major cysteine proteinase, putative 0.0042 0.0254 0.4228
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0524 0.3834 0.3834
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0057 0.0363 0.087
Leishmania major cathepsin L-like protease 0.0054 0.034 0.5655
Loa Loa (eye worm) hypothetical protein 0.0123 0.0854 0.0854
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0129 0.4436
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0162 0.051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0057 0.0363 0.0363
Giardia lamblia Kinase, AGC PKA 0.0029 0.0158 0.2637
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0028 0.0471
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0029 0.0158 0.0161
Brugia malayi Protein kinase domain containing protein 0.005 0.0314 0.0314
Entamoeba histolytica hypothetical protein 0.0046 0.0279 0.0982
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.029 1
Echinococcus multilocularis expressed conserved protein 0.0042 0.0254 0.0259
Trypanosoma cruzi PAB1-binding protein , putative 0.0041 0.0246 0.41
Echinococcus granulosus bloom syndrome protein 0.0029 0.0155 0.0371
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0016 0.005
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.003 0.0162 0.0166
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0155 0.075
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0028 0.0068
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0053 0.0332 0.0798
Brugia malayi follicle stimulating hormone receptor 0.0524 0.3834 0.3834
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0014 0.0044 0.0215
Brugia malayi isocitrate dehydrogenase 0.0013 0.0038 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0122 0.4192
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1204 0.2888
Plasmodium falciparum ataxin-2 like protein, putative 0.0041 0.0246 0.8489
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0028 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0123 0.0854 0.0854
Echinococcus granulosus cGMP dependent protein kinase 0.0042 0.0254 0.061
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0122 0.3327
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.0221 0.0694
Trypanosoma brucei unspecified product 0.0015 0.0049 0.0814
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0089 0.0601 1
Brugia malayi Hr1 repeat family protein 0.003 0.0162 0.0162
Schistosoma mansoni DNA helicase recq1 0.0012 0.0028 0.0089
Echinococcus granulosus survival motor neuron protein 1 0.0569 0.4168 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.014 0.2333
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0162 0.051
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0028 0.0028
Loa Loa (eye worm) RecQ helicase 0.0029 0.0155 0.0155
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0044 0.0127
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0098 0.0098
Onchocerca volvulus 0.0009 0.001 0.003
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Leishmania major cathepsin L-like protease 0.0054 0.034 0.5655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.001 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.1409 0.6824
Brugia malayi Cathepsin L-like precursor 0.0014 0.0044 0.0044
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0022 0.0106 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0366 0.177
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0019 0.0077 0.0185
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.003 0.0162 0.0162
Schistosoma mansoni survival motor neuron protein 0.0116 0.0802 0.2519
Echinococcus multilocularis cysteine protease 0.0014 0.0044 0.0045
Echinococcus multilocularis nervana 2 0.0027 0.0142 0.0145
Loa Loa (eye worm) hypothetical protein 0.0033 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Echinococcus multilocularis histone acetyltransferase MYST2 0.0043 0.026 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Echinococcus granulosus nervana 2 0.0027 0.0142 0.0342
Brugia malayi Importin beta-1 subunit 0.0033 0.0187 0.0187
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0037 0.0213 0.0213
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1334 0.646
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0279 1
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0601 0.2909
Brugia malayi intermediate filament protein 0.0069 0.045 0.045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.018 0.1278 0.1278
Brugia malayi Cathepsin L-like precursor 0.0009 0.001 0.001
Echinococcus multilocularis musashi 0.0069 0.045 0.0459
Schistosoma mansoni hypothetical protein 0.0123 0.0854 0.2683
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0053 0.0332 0.5535
Schistosoma mansoni lamin 0.0069 0.045 0.1415
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0033 0.0186 0.0446
Brugia malayi Cathepsin L-like precursor 0.0014 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0043 0.026 0.026
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0254 0.0798
Entamoeba histolytica protein kinase, putative 0.0057 0.0366 0.13
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0057 0.0363 0.037
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0043 0.026 0.0623
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0022 0.0106 0.0515
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0122 0.3777
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0187 0.5115
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0068 0.0441 0.0441
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0098 0.2953
Onchocerca volvulus Cathepsin F homolog 0.0014 0.0044 0.014
Entamoeba histolytica hypothetical protein 0.0378 0.2747 1
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1334 0.646
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0062 0.2233
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1328 0.9812 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0029 0.0158 0.038
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0013 0.0038 0.1196
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0165 0.0168
Leishmania major cathepsin L-like protease 0.0014 0.0044 0.074
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1353 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Echinococcus granulosus histone acetyltransferase MYST2 0.0043 0.026 0.0623
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.005 0.0314 0.0314
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0098 0.0308
Loa Loa (eye worm) hypothetical protein 0.0041 0.0246 0.0246
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0044 0.0127
Leishmania major cathepsin L-like protease 0.0054 0.034 0.5655
Plasmodium vivax ataxin-2 like protein, putative 0.0041 0.0246 0.7649
Echinococcus multilocularis expressed protein 0.0017 0.0062 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Onchocerca volvulus 0.0038 0.0221 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0029 0.0158 0.2637
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0286 0.2065 0.2065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.034 0.5655
Loa Loa (eye worm) latrophilin receptor protein 2 0.0057 0.0363 0.0363
Onchocerca volvulus Cathepsin L homolog 0.0014 0.0044 0.014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0038 0.0039
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0029 0.0158 0.492
Trichomonas vaginalis ferritin, putative 0.0017 0.0062 0.0301
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.1409 0.6824
Schistosoma mansoni myelin transcription factor 1 myt1 0.0043 0.026 0.0816
Echinococcus multilocularis mitogen activated protein kinase 0.0045 0.0272 0.0277
Loa Loa (eye worm) hypothetical protein 0.0033 0.0187 0.0187
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Onchocerca volvulus 0.0014 0.0044 0.014
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0279 1
Schistosoma mansoni apoferritin-2 0.0017 0.0062 0.0195
Entamoeba histolytica Ran family GTPase 0.0025 0.0122 0.0409
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0053 0.0332 1
Echinococcus granulosus Protein kinase C brain isozyme 0.003 0.0162 0.039
Trichomonas vaginalis AGC family protein kinase 0.005 0.0314 0.1519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Brugia malayi Protein kinase domain containing protein 0.0057 0.0366 0.0366
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0254 0.0798
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0098 0.0476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Loa Loa (eye worm) hypothetical protein 0.003 0.0162 0.0162
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0098 0.1635
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0043 0.026 0.0265
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0029 0.0158 0.2637
Trichomonas vaginalis glucosylceramidase, putative 0.0286 0.2065 1
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0162 0.051
Schistosoma mansoni hypothetical protein 0.0057 0.0363 0.1139
Brugia malayi Calcitonin receptor-like protein seb-1 0.018 0.1278 0.1278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Brugia malayi cathepsin L-like precursor 0.0009 0.001 0.001
Brugia malayi hypothetical protein 0.0041 0.0246 0.0246
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0187 0.3112
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0057 0.0363 0.087
Schistosoma mansoni DNA polymerase eta 0.0021 0.0098 0.0308
Echinococcus granulosus rho-associated protein kinase 1 0.0437 0.3184 0.7639
Echinococcus multilocularis ubiquitin specific protease 41 0.0089 0.0601 0.0612
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0116 0.0802 0.0802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Echinococcus multilocularis nervana 2 0.0027 0.0142 0.0145
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0029 0.0158 0.038
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Brugia malayi hypothetical protein 0.0027 0.0137 0.0137
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0013 0.0038 0.0641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0122 0.0122
Plasmodium vivax vivapain-2 0.0014 0.0044 0.138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1334 0.646
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Leishmania major protein kinase, putative 0.001 0.0016 0.0266
Onchocerca volvulus 0.0014 0.0044 0.014
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0014 0.0044 0.1531
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0038 0.1053
Loa Loa (eye worm) fibroinase 0.0014 0.0044 0.0044
Trypanosoma cruzi Protein kinase B 0.0029 0.0158 0.2637
Entamoeba histolytica protein kinase 2, putative 0.0029 0.0158 0.0543
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0098 0.01
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0002 0.0036
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0053 0.0332 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0028 0.0976
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0158 0.0543
Plasmodium vivax vivapain-2 0.0014 0.0044 0.138
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0242
Loa Loa (eye worm) acetyltransferase 0.0175 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0032 0.0177 0.0177
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0165 0.0396
Brugia malayi mbt repeat family protein 0.0038 0.0221 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0366 0.177
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0098 0.1635
Schistosoma mansoni ran 0.0025 0.0122 0.0382
Brugia malayi mbt repeat family protein 0.0038 0.0221 0.0221
Echinococcus multilocularis mitogen activated protein kinase 3 0.0045 0.0272 0.0277
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Trichomonas vaginalis AGC family protein kinase 0.003 0.0162 0.0787
Plasmodium falciparum importin beta, putative 0.0033 0.0187 0.6445
Loa Loa (eye worm) mbt repeat family protein 0.0038 0.0221 0.0221
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0013 0.0038 0.1158
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0022 0.0106 0.0515
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Echinococcus granulosus nervana 2 0.0027 0.0142 0.0342
Entamoeba histolytica hypothetical protein 0.003 0.0165 0.0568
Plasmodium falciparum ataxin-2 like protein, putative 0.0041 0.0246 0.8489
Echinococcus multilocularis rac serine:threonine kinase 0.0029 0.0158 0.0161
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.0038 0.0092
Schistosoma mansoni ferritin 0.0017 0.0062 0.0195
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0062 0.187
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.0038 0.0039
Trichomonas vaginalis ran, putative 0.0025 0.0122 0.0589
Echinococcus multilocularis Protein kinase C, brain isozyme 0.003 0.0162 0.0166
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0038 0.0641
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0029 0.0158 0.546
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0162 0.051
Schistosoma mansoni apoferritin-2 0.0017 0.0062 0.0195
Echinococcus granulosus ferritin 0.0017 0.0062 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0098 0.1635
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0122 0.0124
Echinococcus granulosus intermediate filament protein 0.0069 0.045 0.1081
Brugia malayi Cathepsin L-like precursor 0.0014 0.0044 0.0044
Echinococcus granulosus dna polymerase eta 0.0021 0.0098 0.0236
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0279 0.762
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0038 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0272 0.1318
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0053 0.0332 0.0339
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.0038 0.0121
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0014 0.0044 0.0044
Echinococcus multilocularis snurportin 1 0.0356 0.2583 0.2632
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0044 0.0215
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.003 0.0162 0.0166
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0028 0.0068
Trichomonas vaginalis importin beta-1, putative 0.0027 0.014 0.0679
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0014 0.0044 0.0215
Trichomonas vaginalis AGC family protein kinase 0.005 0.0314 0.1519
Plasmodium falciparum cGMP-dependent protein kinase 0.0042 0.0254 0.8764
Toxoplasma gondii cathepsin CPL 0.0014 0.0044 0.1215
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0083 0.228
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0013 0.0038 0.1327
Brugia malayi cytoplasmic intermediate filament protein 0.0037 0.0213 0.0213
Brugia malayi Protein kinase domain containing protein 0.003 0.0162 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Echinococcus granulosus cathepsin l1 0.0009 0.001 0.0023
Echinococcus multilocularis protein kinase c iota type 0.003 0.0162 0.0166
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.034 0.5655
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0279 0.762
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.001 0.0013 0.0042
Brugia malayi Egg laying defective protein 4 0.0042 0.0254 0.0254
Schistosoma mansoni cathepsin F (C01 family) 0.0009 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0098
Echinococcus granulosus Glutaredoxin protein 5 0.0027 0.0142 0.0342
Onchocerca volvulus 0.0069 0.045 0.1415
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0162 0.051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0286 0.2065 1
Loa Loa (eye worm) intermediate filament protein 0.0069 0.045 0.045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.018 0.1278 0.1278
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0515
Echinococcus multilocularis survival motor neuron protein 1 0.0569 0.4168 0.4248
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0098 0.1635
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0366 0.177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.034 0.5655
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0062 0.187
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0279 0.8377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0044 0.0215
Schistosoma mansoni ferritin light chain 0.0017 0.0062 0.0195
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.124 0.124
Trypanosoma brucei unspecified product 0.0015 0.0049 0.0814
Schistosoma mansoni lamin 0.0069 0.045 0.1415
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0187 0.3112
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0155 0.0158
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0322 0.1559
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.014 0.0679
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0038 0.1053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0038 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0049 0.0814
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0098 0.0476
Echinococcus granulosus NDR protein kinase 0.003 0.0162 0.039
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0057 0.0363 0.037
Echinococcus granulosus expressed protein 0.0017 0.0062 0.0149

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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