Detailed information for compound 1373557

Basic information

Technical information
  • TDR Targets ID: 1373557
  • Name: 2-amino-N,4-di(phenyl)-1,3-thiazole-5-carboxa mide
  • MW: 295.359 | Formula: C16H13N3OS
  • H donors: 2 H acceptors: 2 LogP: 3.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(c(s1)C(=O)Nc1ccccc1)c1ccccc1
  • InChi: 1S/C16H13N3OS/c17-16-19-13(11-7-3-1-4-8-11)14(21-16)15(20)18-12-9-5-2-6-10-12/h1-10H,(H2,17,19)(H,18,20)
  • InChiKey: USJJTZJZWYSQRZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-N,4-di(phenyl)thiazole-5-carboxamide
  • 2-amino-N,4-di(phenyl)-5-thiazolecarboxamide
  • Oprea1_400606
  • ZINC00042308
  • IDI1_008413
  • MLS001004609
  • SMR000348184
  • IFLab1_000194

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.006 0.0321 0.0499
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0065 0.0371 0.0554
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0257 0.2495 0.7507
Leishmania major proteasome alpha 3 subunit, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) hypothetical protein 0.0043 0.0133 0.0182
Loa Loa (eye worm) matrix metalloproteinase 0.0044 0.0138 0.019
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0065 0.0371 0.0336
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0257 0.2495 0.2467
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0065 0.0371 0.0749
Plasmodium falciparum cysteine repeat modular protein 1 0.0089 0.0632 0.1415
Brugia malayi Matrixin family protein 0.0044 0.0138 0.0215
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0065 0.0371 0.0554
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0054 0.0244 0.038
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0371 0.0749
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0065 0.0371 0.1022
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0257 0.2495 0.7432
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0065 0.0371 0.0749
Mycobacterium ulcerans hydrolase 0.0054 0.0244 0.035
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0371 0.0749
Leishmania major proteasome beta-1 subunit, putative 0.0065 0.0371 0.0749
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0065 0.0371 0.0336
Trypanosoma cruzi 20S proteasome subunit 0.0159 0.1414 0.4029
Brugia malayi proteasome subunit beta type 3 0.0065 0.0371 0.0578
Loa Loa (eye worm) hypothetical protein 0.0043 0.0133 0.0182
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0065 0.0371 0.0749
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0054 0.0244 0.035
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0065 0.0371 0.0336
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0065 0.0371 0.0749
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0065 0.0371 0.0749
Brugia malayi Matrixin family protein 0.0044 0.0138 0.0215
Brugia malayi beta-lactamase 0.0043 0.0133 0.0207
Brugia malayi Hemopexin family protein 0.0062 0.0342 0.0532
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0159 0.1414 0.1382
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0321 0.0298
Loa Loa (eye worm) hypothetical protein 0.0096 0.071 0.1083
Onchocerca volvulus Matrilysin homolog 0.0044 0.0138 0.0008
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0096 0.071 0.1083
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0065 0.0371 0.0749
Brugia malayi Protein kinase domain containing protein 0.0089 0.0632 0.0984
Brugia malayi beta-lactamase family protein 0.0043 0.0133 0.0207
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.016 0.142 0.1388
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0159 0.1414 0.4029
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0065 0.0371 0.0554
Schistosoma mansoni hypothetical protein 0.0062 0.0342 0.0507
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0065 0.0371 0.0749
Plasmodium vivax proteasome subunit beta type-1, putative 0.0257 0.2495 0.7432
Leishmania major proteasome beta 5 subunit, putative 0.0331 0.3311 1
Plasmodium vivax proteasome subunit beta type-4, putative 0.0065 0.0371 0.0749
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0065 0.0371 0.1022
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0065 0.0371 0.0578
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0065 0.0371 0.0578
Loa Loa (eye worm) proteasome subunit beta type 2 0.0159 0.1414 0.218
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0065 0.0371 0.0336
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0065 0.0371 0.0749
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) hypothetical protein 0.0612 0.6425 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0331 0.3311 0.5141
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0612 0.6425 0.6412
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0065 0.0371 0.0749
Echinococcus multilocularis proteasome subunit alpha type 2 0.0065 0.0371 0.0336
Loa Loa (eye worm) proteasome subunit beta type 1 0.0257 0.2495 0.3868
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) hypothetical protein 0.006 0.0321 0.0475
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0141 0.0105
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0065 0.0371 0.0749
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0065 0.0371 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0133 0.0182
Echinococcus multilocularis proteasome (prosome, macropain) 0.0331 0.3311 0.3287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0141 0.0194
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0065 0.0371 0.0578
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0065 0.0371 0.0749
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0065 0.0371 0.0554
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0065 0.0371 0.1022
Echinococcus multilocularis apoptotic protease activating factor 1 0.006 0.0321 0.0285
Loa Loa (eye worm) hypothetical protein 0.0044 0.0138 0.019
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0065 0.0371 0.0578
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0065 0.0371 0.0749
Schistosoma mansoni hypothetical protein 0.0164 0.1463 0.2257
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0065 0.0371 0.0749
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0133 0.0097
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0096 0.071 0.0676
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0065 0.0371 0.0749
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0331 0.3311 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0133 0.0182
Loa Loa (eye worm) hypothetical protein 0.0089 0.0632 0.0961
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0065 0.0371 0.0749
Leishmania major hypothetical protein, conserved 0.0049 0.0191 0.0182
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.016 0.142 0.1388
Mycobacterium ulcerans proteasome PrcA 0.0065 0.0371 0.0749
Echinococcus multilocularis geminin 0.0164 0.1463 0.1431
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0099 0.0747 0.0713
Toxoplasma gondii proteasome subunit 0.0065 0.0371 0.0749
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0065 0.0371 0.0554
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0065 0.0371 0.0749
Schistosoma mansoni hypothetical protein 0.0089 0.0632 0.0961
Schistosoma mansoni ankyrin 23/unc44 0.0096 0.071 0.1083
Brugia malayi beta-lactamase family protein 0.0043 0.0133 0.0207
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0065 0.0371 0.0749
Brugia malayi Proteasome A-type and B-type family protein 0.0065 0.0371 0.0578
Leishmania major hypothetical protein, conserved 0.0089 0.0632 0.1571
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0065 0.0371 0.1022
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0191 0.0182
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0065 0.0371 0.0749
Toxoplasma gondii kringle domain-containing protein 0.0089 0.0632 0.1571
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0065 0.0371 0.0554
Toxoplasma gondii proteasome subunit alpha type, putative 0.0065 0.0371 0.0749
Echinococcus multilocularis caspase 2 0.006 0.0321 0.0285
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0065 0.0371 0.1022
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0065 0.0371 0.0749
Brugia malayi Proteasome subunit alpha type 7-1 0.0065 0.0371 0.0578
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0065 0.0371 0.0578
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0065 0.0371 0.0336
Echinococcus multilocularis proteasome subunit beta type 7 0.0065 0.0371 0.0336
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0185 0.0288
Echinococcus granulosus death domain containing protein 0.0096 0.071 0.0676
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0612 0.6425 1
Brugia malayi Matrixin family protein 0.0044 0.0138 0.0215
Onchocerca volvulus 0.006 0.0321 0.0298
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0065 0.0371 0.0749
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0065 0.0371 0.0554
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0065 0.0371 0.0578
Schistosoma mansoni hypothetical protein 0.0612 0.6425 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0257 0.2495 0.7432
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0257 0.2495 0.7432
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0065 0.0371 0.0749
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0159 0.1414 0.4029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0133 0.0182
Loa Loa (eye worm) beta-lactamase 0.0043 0.0133 0.0182
Echinococcus multilocularis netrin receptor unc 5 0.0096 0.071 0.0676
Loa Loa (eye worm) matrixin family protein 0.0106 0.0828 0.1266
Leishmania major proteasome alpha 7 subunit, putative 0.0065 0.0371 0.0749
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0065 0.0371 0.0749
Brugia malayi proteasome subunit beta type 2 0.0159 0.1414 0.22
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0191 0.0182
Brugia malayi proteasome subunit beta type 1 0.0257 0.2495 0.3883
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0061 0.0325 0.0289
Onchocerca volvulus 0.0062 0.0342 0.0331
Echinococcus granulosus tissue type plasminogen activator 0.0089 0.0632 0.0598
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0331 0.3311 0.5141
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0065 0.0371 0.0336
Brugia malayi 20S proteasome alpha5 subunit 0.0065 0.0371 0.0578
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0065 0.0371 0.0749
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0612 0.6425 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0065 0.0371 0.0336
Plasmodium falciparum proteasome subunit beta type-4 0.0065 0.0371 0.0578
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0065 0.0371 0.0554
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0065 0.0371 0.0749
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0185 0.0288
Brugia malayi Cell death protein 3 precursor 0.006 0.0321 0.0499
Brugia malayi proteasome subunit alpha type 1 0.0065 0.0371 0.0578
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0141 0.0105
Echinococcus granulosus proteasome prosome macropain 0.0331 0.3311 0.3287
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0141 0.0105
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0065 0.0371 0.0749
Plasmodium vivax proteasome subunit beta type-5, putative 0.0331 0.3311 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0133 0.0182
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0141 0.0194
Loa Loa (eye worm) matrixin family protein 0.0097 0.073 0.1114
Echinococcus granulosus apoptotic protease activating factor 1 0.006 0.0321 0.0285
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0065 0.0371 0.0554
Trypanosoma brucei proteasome beta 7 subunit 0.0065 0.0371 0.0749
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0371 0.0749
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0257 0.2495 0.3868
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0159 0.1414 0.218
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0159 0.1414 0.1382
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0065 0.0371 0.0749
Onchocerca volvulus Deterin homolog 0.0612 0.6425 1
Brugia malayi Protein kinase domain containing protein 0.0096 0.071 0.1106
Brugia malayi Proteasome A-type and B-type family protein 0.0065 0.0371 0.0578
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0133 0.0097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0133 0.0182
Brugia malayi hypothetical protein 0.0035 0.0037 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0191 0.0182
Leishmania major proteasome beta 2 subunit, putative 0.0065 0.0371 0.0749
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0936 1 1
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0065 0.0371 0.0554
Echinococcus granulosus Proteasome subunit alpha type 7 0.0065 0.0371 0.0336
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0065 0.0371 0.0749
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) hypothetical protein 0.0054 0.0244 0.0356
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0331 0.3311 1
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0065 0.0371 0.0578
Echinococcus granulosus proteasome subunit alpha type 6 0.0065 0.0371 0.0336
Loa Loa (eye worm) hypothetical protein 0.006 0.0321 0.0475
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0089 0.0632 0.1571
Echinococcus granulosus Proteasome subunit alpha beta 0.0065 0.0371 0.0336
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0065 0.0371 0.0749
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0065 0.0371 0.0749
Echinococcus granulosus subfamily T1A non peptidase ue 0.0065 0.0371 0.0336
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0065 0.0371 0.0749
Brugia malayi Proteasome A-type and B-type family protein 0.0065 0.0371 0.0578
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0065 0.0371 0.0749
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0141 0.0105
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0065 0.0371 0.0336
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0331 0.3311 1
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0065 0.0371 0.0336
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0632 0.1571
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0065 0.0371 0.0749
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0331 0.3311 1
Brugia malayi proteasome subunit alpha type 4 0.0065 0.0371 0.0578
Echinococcus granulosus proteasome subunit beta type 7 0.0065 0.0371 0.0336
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0159 0.1414 0.4029
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0065 0.0371 0.0749
Giardia lamblia Proteasome subunit beta type 2 0.0159 0.1414 0.3546
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0032
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) TK/ROR protein kinase 0.0089 0.0632 0.0961
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0065 0.0371 0.0554
Echinococcus granulosus glutamate NMDA receptor subunit 0.0061 0.0325 0.0289
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0065 0.0371 0.0554
Brugia malayi Subtilase family protein 0.0264 0.2577 0.401
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0065 0.0371 0.1022
Leishmania major proteasome beta 3 subunit, putative 0.0065 0.0371 0.0749
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0065 0.0371 0.0749
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0321 0.0475
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0065 0.0371 0.0749
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0331 0.3311 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0065 0.0371 0.0554
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0065 0.0371 0.1022
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0096 0.071 0.0676
Loa Loa (eye worm) hypothetical protein 0.0048 0.0185 0.0263
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0065 0.0371 0.1022
Echinococcus multilocularis inhibitor of apoptosis protein 0.0612 0.6425 0.6412
Echinococcus multilocularis proteasome subunit beta type 6 0.0065 0.0371 0.0336
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0065 0.0371 0.1022
Plasmodium vivax proteasome subunit beta type-2, putative 0.0159 0.1414 0.4029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0133 0.0207
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0065 0.0371 0.1022
Brugia malayi Proteasome subunit alpha type 1 0.0065 0.0371 0.0578
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0065 0.0371 0.1022
Loa Loa (eye worm) proteasome subunit beta type 3 0.0065 0.0371 0.0554
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0065 0.0371 0.1022
Toxoplasma gondii peptidase, T1 family protein 0.0065 0.0371 0.0749
Onchocerca volvulus Matrilysin homolog 0.0097 0.073 0.0949
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0065 0.0371 0.0578
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0159 0.1414 0.3919
Echinococcus granulosus netrin receptor unc 5 0.0096 0.071 0.0676
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0065 0.0371 0.0336
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0065 0.0371 0.0554
Echinococcus granulosus proteasome subunit beta t family 0.0065 0.0371 0.0336
Echinococcus multilocularis proteasome subunit alpha type 6 0.0065 0.0371 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0141 0.0194
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0331 0.3311 1
Schistosoma mansoni glutamate receptor NMDA 0.0061 0.0325 0.0482
Echinococcus multilocularis tissue type plasminogen activator 0.0089 0.0632 0.0598
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0065 0.0371 0.0749
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) subtilase 0.0264 0.2577 0.3995
Onchocerca volvulus Notchless protein homolog 0.0065 0.0371 0.0379
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2724 0.8152
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0065 0.0371 0.0554
Loa Loa (eye worm) hypothetical protein 0.0044 0.0138 0.019
Brugia malayi Matrixin family protein 0.0044 0.0138 0.0215
Onchocerca volvulus Matrix metalloproteinase homolog 0.0097 0.073 0.0949
Loa Loa (eye worm) PAS-3 protein 0.0065 0.0371 0.0554
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0065 0.0371 0.0749
Plasmodium vivax proteasome subunit beta type-6, putative 0.0065 0.0371 0.0749
Brugia malayi hypothetical protein 0.0049 0.0191 0.0297
Schistosoma mansoni hypothetical protein 0.0096 0.071 0.1083
Echinococcus granulosus Ankyrin 0.0096 0.0715 0.068
Brugia malayi Kringle domain containing protein 0.0089 0.0632 0.0984
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0065 0.0371 0.0749
Brugia malayi proteasome subunit alpha type 2 0.0065 0.0371 0.0578
Echinococcus granulosus caspase 2 0.006 0.0321 0.0285
Onchocerca volvulus 0.0612 0.6425 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0054 0.0244 0.035
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0257 0.2495 0.7384
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) hypothetical protein 0.0612 0.6425 1
Leishmania major proteasome beta 2 subunit, putative 0.0159 0.1414 0.4029
Leishmania major proteasome alpha 2 subunit, putative 0.0065 0.0371 0.0749
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0065 0.0371 0.0749
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0065 0.0371 0.0554
Brugia malayi Proteasome A-type and B-type family protein 0.0331 0.3311 0.5154
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0065 0.0371 0.0749
Leishmania major proteasome beta 7 subunit, putative 0.0065 0.0371 0.0749
Plasmodium falciparum proteasome subunit beta type-5 0.0331 0.3311 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0612 0.6425 0.6412
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0065 0.0371 0.0554
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0065 0.0371 0.0749
Brugia malayi Matrixin family protein 0.0106 0.0828 0.1288
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0185 0.0263
Onchocerca volvulus Netrin receptor homolog 0.0096 0.071 0.0918
Onchocerca volvulus 0.0089 0.0632 0.0793
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0371 0.0749
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0065 0.0371 0.0749
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0065 0.0371 0.0749
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0037 0.0032
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0257 0.2495 0.7432
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0065 0.0371 0.0554
Leishmania major proteasome alpha 1 subunit, putative 0.0065 0.0371 0.0749
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0264 0.2577 0.3995
Leishmania major proteasome alpha 1 subunit, putative 0.0065 0.0371 0.0749
Toxoplasma gondii heat shock protein hslv, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) hypothetical protein 0.0096 0.0715 0.1089
Plasmodium vivax proteasome subunit beta type-7, putative 0.0065 0.0371 0.0749
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0065 0.0371 0.0749
Toxoplasma gondii proteasome subunit alpha1, putative 0.0065 0.0371 0.0749
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0065 0.0371 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0191 0.0272
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0159 0.1414 0.4205
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0065 0.0371 0.1022
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0099 0.0747 0.0713
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0065 0.0371 0.0749
Plasmodium vivax proteasome subunit beta type-3, putative 0.0065 0.0371 0.0749
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0065 0.0371 0.0336
Mycobacterium ulcerans proteasome PrcB 0.0331 0.3311 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0191 0.0182
Loa Loa (eye worm) hypothetical protein 0.0043 0.0133 0.0182
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0191 0.0182
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0257 0.2495 0.2467
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0065 0.0371 0.0578
Leishmania major proteasome alpha 7 subunit, putative 0.0065 0.0371 0.0749
Schistosoma mansoni hypothetical protein 0.006 0.0321 0.0475
Echinococcus multilocularis Ankyrin 0.0096 0.0715 0.068
Trypanosoma brucei proteasome alpha 7 subunit 0.0065 0.0371 0.0749
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0612 0.6425 0.6412
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0065 0.0371 0.0749
Brugia malayi Death domain containing protein 0.0096 0.071 0.1106
Giardia lamblia Proteasome subunit beta type 1 0.0257 0.2495 0.7224
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0159 0.1414 0.218
Schistosoma mansoni netrin receptor unc5 0.0096 0.071 0.1083
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0065 0.0371 0.0554
Brugia malayi proteasome subunit alpha type 3 0.0065 0.0371 0.0578
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0159 0.1414 0.4029
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0159 0.1414 0.4029
Schistosoma mansoni inhibitor of apoptosis protein 0.0612 0.6425 1
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0065 0.0371 0.1022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0141 0.0219
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0065 0.0371 0.0749
Brugia malayi Uncoordinated protein 44 0.0096 0.071 0.1106
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0065 0.0371 0.0749
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0133 0.0182
Schistosoma mansoni hypothetical protein 0.0164 0.1463 0.2257
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0065 0.0371 0.0749
Brugia malayi proteasome subunit alpha type 6 0.0065 0.0371 0.0578
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0141 0.0194
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0065 0.0371 0.0578
Echinococcus granulosus proteasome subunit alpha type 2 0.0065 0.0371 0.0336
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0257 0.2495 0.7432
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0065 0.0371 0.1022
Onchocerca volvulus 0.0044 0.0138 0.0008
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0331 0.3311 1
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0065 0.0371 0.0554
Loa Loa (eye worm) hypothetical protein 0.0044 0.0138 0.019
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0065 0.0371 0.0749
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0065 0.0371 0.1022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0096 0.071 0.1106
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0065 0.0371 0.0578
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0065 0.0371 0.0749
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0065 0.0371 0.0554
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0016 0.0025
Echinococcus granulosus proteasome subunit beta type 6 0.0065 0.0371 0.0336
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0096 0.0715 0.1089
Toxoplasma gondii proteasome subunit beta type, putative 0.0331 0.3311 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0065 0.0371 0.0749
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0065 0.0371 0.0749
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0044 0.0138 0.019
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0065 0.0371 0.0554
Toxoplasma gondii proteasome beta subunit 0.0065 0.0371 0.0749
Trypanosoma brucei proteasome beta 6 subunit 0.0257 0.2495 0.7432
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0065 0.0371 0.0554
Echinococcus granulosus geminin 0.0164 0.1463 0.1431
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0065 0.0371 0.0554
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0331 0.3311 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0612 0.6425 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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