Detailed information for compound 1375509

Basic information

Technical information
  • TDR Targets ID: 1375509
  • Name: (4-nitrophenyl) 4-chloro-3-piperidin-1-ylsulf onylbenzoate
  • MW: 424.855 | Formula: C18H17ClN2O6S
  • H donors: 0 H acceptors: 5 LogP: 3.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)S(=O)(=O)N1CCCCC1)Cl)Oc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C18H17ClN2O6S/c19-16-9-4-13(12-17(16)28(25,26)20-10-2-1-3-11-20)18(22)27-15-7-5-14(6-8-15)21(23)24/h4-9,12H,1-3,10-11H2
  • InChiKey: AXMOCFQZWXVXDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-nitrophenyl) 4-chloro-3-(1-piperidylsulfonyl)benzoate
  • 4-chloro-3-(1-piperidylsulfonyl)benzoic acid (4-nitrophenyl) ester
  • 4-chloro-3-piperidinosulfonyl-benzoic acid (4-nitrophenyl) ester
  • (4-nitrophenyl) 4-chloro-3-piperidin-1-ylsulfonyl-benzoate
  • Oprea1_574876
  • MLS000554551
  • SMR000171230
  • ZINC00832288
  • 4-Chloro-3-(piperidine-1-sulfonyl)-benzoic acid 4-nitro-phenyl ester
  • BAS 00154310

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SH2 domain containing protein 0.0019 0.0271 0.0585
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0535 0.0535
Echinococcus granulosus G1Y162 protein 0.0046 0.209 0.2275
Plasmodium vivax tyrosine kinase-like protein, putative 0.0015 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0046 0.209 0.4518
Echinococcus granulosus lachesin 0.0038 0.1557 0.1696
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) projectin 0.0084 0.4625 1
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Schistosoma mansoni tyrosine kinase 0.0023 0.0535 0.0535
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0038 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Brugia malayi protein-tyrosine kinase 0.0019 0.0271 0.0585
Echinococcus granulosus neuroglian 0.0084 0.4625 0.5036
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0015 0 0.5
Giardia lamblia Kinase 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.9184 1
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) UNCoordinated family member 0.0046 0.209 0.4518
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0023 0.0535 0.0582
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0023 0.0535 0.0535
Echinococcus multilocularis roundabout 2 0.0084 0.4625 0.4625
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0046 0.209 0.4518
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0015 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0023 0.0535 0.0582
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0084 0.4625 0.4625
Echinococcus multilocularis insulin growth factor binding 0.0038 0.1557 0.1557
Echinococcus granulosus c src tyrosine kinase 0.0023 0.0535 0.0582
Onchocerca volvulus 0.0038 0.1557 0.3367
Schistosoma mansoni tyrosine kinase 0.0023 0.0535 0.0535
Brugia malayi Fibronectin type III domain containing protein 0.0046 0.209 0.4518
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0046 0.209 0.209
Schistosoma mansoni hypothetical protein 0.0038 0.1557 0.1557
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0264 0.0264
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0535 0.0582
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Onchocerca volvulus 0.0038 0.1557 0.3367
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0046 0.209 0.2275
Onchocerca volvulus 0.0046 0.209 0.4518
Loa Loa (eye worm) hypothetical protein 0.0084 0.4625 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3923 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0084 0.4625 1
Echinococcus multilocularis Fibronectin, type III 0.0046 0.209 0.209
Schistosoma mansoni factor for adipocyte differentiation 0.0046 0.209 0.209
Brugia malayi Peroxidasin 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0019 0.0271 0.0295
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis neuroglian 0.0084 0.4625 0.4625
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) hypothetical protein 0.0019 0.0271 0.0585
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Brugia malayi Prion-like- 0.0038 0.1557 0.3367
Onchocerca volvulus 0.0046 0.209 0.4518
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.3923 1
Plasmodium vivax protein kinase, putative 0.0015 0 0.5
Brugia malayi SH2 domain containing protein 0.0019 0.0271 0.0585
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0046 0.209 0.209
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Onchocerca volvulus 0.0084 0.4625 1
Echinococcus granulosus hemicentin 1 0.0038 0.1557 0.1696
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.3923 0.3923
Echinococcus granulosus titin 0.0038 0.1557 0.1696
Echinococcus granulosus insulin growth factor binding 0.0038 0.1557 0.1696
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0084 0.4625 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Echinococcus multilocularis titin 0.0038 0.1557 0.1557
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus granulosus nephrin 0.0084 0.4625 0.5036
Brugia malayi SPRY domain containing protein 0.0046 0.209 0.4518
Loa Loa (eye worm) TK protein kinase 0.0053 0.2535 0.5482
Echinococcus multilocularis Netrin receptor DCC 0.0046 0.209 0.209
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0046 0.209 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Onchocerca volvulus 0.0038 0.1557 0.3367
Loa Loa (eye worm) TK/ABL protein kinase 0.0019 0.0271 0.0585
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.3923 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0535 0.0535
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Onchocerca volvulus Peroxidasin homolog 0.0038 0.1557 0.3367
Schistosoma mansoni cell adhesion molecule 0.0038 0.1557 0.1557
Onchocerca volvulus 0.0019 0.0271 0.0585
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus granulosus anosmin 1 0.0046 0.209 0.2275
Schistosoma mansoni cell adhesion molecule 0.0084 0.4625 0.4625
Schistosoma mansoni nephrin 0.0084 0.4625 0.4625
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0038 0.1557 0.1557
Trichomonas vaginalis CAMK family protein kinase 0.0015 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Echinococcus granulosus contactin 0.0084 0.4625 0.5036
Echinococcus granulosus tyrosine protein kinase Srms 0.0019 0.0271 0.0295
Schistosoma mansoni hypothetical protein 0.0084 0.4625 0.4625
Echinococcus granulosus leucine rich repeat containing protein 4 0.0038 0.1557 0.1696
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0046 0.209 0.4518
Echinococcus granulosus anosmin 1 0.0046 0.209 0.2275
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Brugia malayi protein unc-22 0.0084 0.4625 1
Brugia malayi Prion-like- 0.0038 0.1557 0.3367
Echinococcus multilocularis hemicentin 1 0.0038 0.1557 0.1557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0046 0.209 0.4518
Onchocerca volvulus 0.0019 0.0271 0.0585
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0019 0.0271 0.0295
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Echinococcus granulosus tyrosine protein kinase ABL1 0.0019 0.0271 0.0295
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.1557 0.3367
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0038 0.1557 0.1696
Onchocerca volvulus Peroxidasin homolog 0.0038 0.1557 0.3367
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0053 0.2535 0.2535
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0084 0.4625 0.5036
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Schistosoma mansoni tyrosine kinase 0.0053 0.2535 0.2535
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Schistosoma mansoni hemicentin 0.0084 0.4625 0.4625
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0053 0.2535 0.276
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.1557 0.3367
Echinococcus multilocularis cell adhesion molecule 0.0046 0.209 0.209
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0038 0.1557 0.1557
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.3923 0.5
Onchocerca volvulus 0.0046 0.209 0.4518
Echinococcus multilocularis roundabout 2 0.0084 0.4625 0.4625
Schistosoma mansoni ephrin receptor 0.0061 0.3068 0.3068
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0061 0.3068 0.3068
Echinococcus granulosus tyrosine protein kinase Src64B 0.0023 0.0535 0.0582
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Onchocerca volvulus 0.0019 0.0271 0.0585
Onchocerca volvulus 0.0038 0.1557 0.3367
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.4625 0.4625
Echinococcus granulosus tyrosine protein kinase Lyn 0.0023 0.0535 0.0582
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0084 0.4625 0.4625
Echinococcus granulosus roundabout 2 0.0084 0.4625 0.5036
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Onchocerca volvulus 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Schistosoma mansoni hypothetical protein 0.0046 0.209 0.209
Brugia malayi Fibronectin type III domain containing protein 0.0046 0.209 0.4518
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) one IG domain family member 0.0038 0.1557 0.3367
Onchocerca volvulus 0.0038 0.1557 0.3367
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0023 0.0535 0.0535
Echinococcus granulosus fibronectin type III domain-containing protein 0.0046 0.209 0.2275
Onchocerca volvulus 0.0019 0.0271 0.0585
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0015 0 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0053 0.2535 0.5482
Brugia malayi Fibronectin type III domain containing protein 0.0046 0.209 0.4518
Echinococcus granulosus tyrosine protein kinase Src42A 0.0023 0.0535 0.0582
Schistosoma mansoni titin 0.0038 0.1557 0.1557
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0015 0 0.5
Echinococcus multilocularis titin 0.0038 0.1557 0.1557
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0046 0.209 0.4518
Onchocerca volvulus Netrin receptor homolog 0.0038 0.1557 0.3367
Echinococcus multilocularis hemicentin 1 0.0038 0.1557 0.1557
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0046 0.209 0.2275
Loa Loa (eye worm) disorganized muscle protein 1 0.0038 0.1557 0.3367
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Echinococcus multilocularis 0.0038 0.1557 0.1557
Schistosoma mansoni titin 0.0046 0.209 0.209
Echinococcus multilocularis tyrosine protein kinase otk 0.0038 0.1557 0.1557
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0046 0.209 1
Echinococcus granulosus Netrin receptor DCC 0.0046 0.209 0.2275
Echinococcus multilocularis titin 0.0084 0.4625 0.4625
Echinococcus multilocularis lachesin 0.0038 0.1557 0.1557
Echinococcus multilocularis anosmin 1 0.0046 0.209 0.209
Echinococcus multilocularis neuroglian 0.0038 0.1557 0.1557
Giardia lamblia Kinase, NEK 0.0015 0 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0023 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Brugia malayi Myb-like DNA-binding domain containing protein 0.0038 0.1557 0.3367
Brugia malayi Fibronectin type III domain containing protein 0.0046 0.209 0.4518
Echinococcus multilocularis c src tyrosine kinase 0.0023 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0038 0.1557 0.1696
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Schistosoma mansoni hypothetical protein 0.0152 0.9184 0.9184
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Brugia malayi SRC-1 0.0023 0.0535 0.1156
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.2535 0.5482
Trichomonas vaginalis AGC family protein kinase 0.0015 0 0.5
Giardia lamblia Kinase, NEK 0.0015 0 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0084 0.4625 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0019 0.0271 0.0271
Brugia malayi Fibronectin type III domain containing protein 0.0046 0.209 0.4518
Brugia malayi Lethal protein 805 0.0046 0.209 0.4518
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Brugia malayi hypothetical protein 0.0046 0.209 0.4518
Schistosoma mansoni factor for adipocyte differentiation 0.0046 0.209 0.209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.209 0.4518
Trichomonas vaginalis STE family protein kinase 0.0015 0 0.5
Schistosoma mansoni septate junction protein 0.0038 0.1557 0.1557
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0084 0.4625 1
Brugia malayi Protein kinase domain containing protein 0.0019 0.0271 0.0585
Echinococcus granulosus EG95 0.0046 0.209 0.2275
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Schistosoma mansoni hypothetical protein 0.0038 0.1557 0.1557
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Schistosoma mansoni factor for adipocyte differentiation 0.0046 0.209 0.209
Brugia malayi Tyrosine-protein kinase abl-1 0.0023 0.0535 0.1156
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Giardia lamblia Protein 21.1 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0084 0.4625 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0084 0.4625 0.4625
Onchocerca volvulus 0.0046 0.209 0.4518
Schistosoma mansoni tripartite motif protein trim9 0.0046 0.209 0.209
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0019 0.0271 0.0271
Schistosoma mansoni tyrosine kinase 0.0019 0.0271 0.0271
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Schistosoma mansoni hypothetical protein 0.0038 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Schistosoma mansoni slit 0.0038 0.1557 0.1557
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Onchocerca volvulus 0.0046 0.209 0.4518
Onchocerca volvulus 0.0019 0.0271 0.0585
Echinococcus multilocularis Netrin receptor DCC 0.0046 0.209 0.209
Schistosoma mansoni tyrosine kinase 0.0019 0.0271 0.0271
Brugia malayi Leucine Rich Repeat family protein 0.0038 0.1557 0.3367
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Echinococcus multilocularis down syndrome cell adhesion 0.0038 0.1557 0.1557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Schistosoma mansoni septate junction protein 0.0038 0.1557 0.1557
Echinococcus granulosus anosmin 1 0.0046 0.209 0.2275
Echinococcus granulosus neuroglian 0.0038 0.1557 0.1696
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0046 0.209 0.4518
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0015 0 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.209 0.2275
Echinococcus granulosus tyrosine protein kinase shark 0.0019 0.0271 0.0295
Schistosoma mansoni neuroglian 0.0084 0.4625 0.4625
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0019 0.0271 0.0271
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Schistosoma mansoni thyroid hormone receptor 0.0164 1 1
Leishmania major hypothetical protein, conserved 0.0046 0.209 0.5327
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.1557 0.3367
Echinococcus granulosus tyrosine kinase 0.0019 0.0271 0.0295
Onchocerca volvulus 0.0084 0.4625 1
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0046 0.209 0.4518
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.209 1
Onchocerca volvulus 0.0019 0.0271 0.0585
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.209 0.209
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0061 0.3068 0.334
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Brugia malayi Prion-like- 0.0038 0.1557 0.3367
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) hypothetical protein 0.0084 0.4625 1
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0046 0.209 0.209
Onchocerca volvulus 0.0046 0.209 0.4518
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0023 0.0535 0.0535
Schistosoma mansoni cell adhesion molecule 0.0038 0.1557 0.1557
Echinococcus granulosus titin 0.0084 0.4625 0.5036
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0084 0.4625 1
Schistosoma mansoni titin 0.0038 0.1557 0.1557
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Schistosoma mansoni titin 0.0038 0.1557 0.1557
Echinococcus granulosus peroxidasin 0.0038 0.1557 0.1696
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Schistosoma mansoni titin 0.0038 0.1557 0.1557
Echinococcus granulosus usherin 0.0046 0.209 0.2275
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0038 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) myotactin form A 0.0046 0.209 0.4518
Trichomonas vaginalis conserved hypothetical protein 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Schistosoma mansoni tyrosine kinase 0.0023 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Echinococcus granulosus Netrin receptor DCC 0.0046 0.209 0.2275
Echinococcus multilocularis twitchin 0.0038 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Brugia malayi Prion-like- 0.0038 0.1557 0.3367
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0023 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.1557 0.3367
Brugia malayi Lethal protein 805 0.0046 0.209 0.4518
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.209 0.209
Trichomonas vaginalis conserved hypothetical protein 0.0015 0 0.5
Brugia malayi hypothetical protein 0.0019 0.0271 0.0585
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Schistosoma mansoni titin 0.0084 0.4625 0.4625
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis titin 0.0046 0.209 0.209
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.3923 0.3923
Schistosoma mansoni cell adhesion molecule 0.0084 0.4625 0.4625
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.3923 0.3923
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Brugia malayi Fibronectin type III domain containing protein 0.0046 0.209 0.4518
Onchocerca volvulus 0.0046 0.209 0.4518
Trichomonas vaginalis protein tyrosine kinase, putative 0.0015 0 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Brugia malayi myotactin form B 0.0046 0.209 0.4518
Schistosoma mansoni hypothetical protein 0.0046 0.209 0.209
Trichomonas vaginalis conserved hypothetical protein 0.0015 0 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0019 0.0271 1
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Echinococcus multilocularis tyrosine protein kinase shark 0.0019 0.0271 0.0271
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0019 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis roundabout 2 0.0084 0.4625 0.4625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Onchocerca volvulus 0.0046 0.209 0.4518
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0023 0.0535 0.0535
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Schistosoma mansoni cell adhesion molecule 0.0046 0.209 0.209
Loa Loa (eye worm) lethal protein 805 0.0046 0.209 0.4518
Schistosoma mansoni protein tyrosine phosphatase 0.0046 0.209 0.209
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0038 0.1557 0.1557
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0046 0.209 0.209
Schistosoma mansoni nephrin related 0.0038 0.1557 0.1557
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.1557 0.1557
Schistosoma mansoni titin 0.0038 0.1557 0.1557
Schistosoma mansoni cell adhesion molecule 0.0084 0.4625 0.4625
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.2535 0.5482
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.209 0.4518
Brugia malayi Protein kinase domain containing protein 0.0019 0.0271 0.0585
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.209 0.209
Echinococcus granulosus cell adhesion molecule 0.0046 0.209 0.2275
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis anosmin 1 0.0046 0.209 0.209
Schistosoma mansoni titin 0.0084 0.4625 0.4625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0046 0.209 0.209
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Echinococcus multilocularis transfer RNA-Phe 0.0084 0.4625 0.4625
Schistosoma mansoni hypothetical protein 0.0038 0.1557 0.1557
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0046 0.209 0.4518
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0023 0.0535 0.0535
Echinococcus granulosus twitchin 0.0038 0.1557 0.1696
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0046 0.209 1
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0038 0.1557 0.3367
Plasmodium falciparum protein kinase, putative 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0046 0.209 0.209
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis titin 0.0038 0.1557 0.1557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Schistosoma mansoni tyrosine kinase 0.0023 0.0535 0.0535
Schistosoma mansoni thyroid hormone receptor 0.0164 1 1
Echinococcus granulosus tyrosine kinase 0.0019 0.0271 0.0295
Loa Loa (eye worm) CAMK protein kinase 0.0084 0.4625 1
Brugia malayi hypothetical protein 0.0046 0.209 0.4518
Brugia malayi kettin 0.0038 0.1557 0.3367
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0015 0 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0015 0 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3923 0.5
Schistosoma mansoni roundabout 0.0038 0.1557 0.1557
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.3923 0.4272
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.1557 0.3367
Onchocerca volvulus Putative titin 0.0038 0.1557 0.3367
Brugia malayi Protein kinase domain containing protein 0.0019 0.0271 0.0585
Trichomonas vaginalis TK family protein kinase 0.0015 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0535 0.0582
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0084 0.4625 0.4625
Schistosoma mansoni titin 0.0038 0.1557 0.1557
Echinococcus multilocularis peroxidasin 0.0038 0.1557 0.1557
Brugia malayi Protein-tyrosine phosphatase 0.0046 0.209 0.4518
Onchocerca volvulus 0.0046 0.209 0.4518
Plasmodium vivax tyrosine kinase-like protein, putative 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Echinococcus granulosus titin 0.0038 0.1557 0.1696
Onchocerca volvulus 0.0084 0.4625 1
Onchocerca volvulus 0.0046 0.209 0.4518
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0046 0.209 0.2275
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0038 0.1557 0.3367
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus granulosus roundabout 2 0.0084 0.4625 0.5036
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0084 0.4625 0.4625
Schistosoma mansoni cell adhesion molecule 0.0084 0.4625 0.4625
Brugia malayi myotactin form A 0.0046 0.209 0.4518
Brugia malayi Protein kinase domain containing protein 0.0019 0.0271 0.0585
Echinococcus granulosus down syndrome cell adhesion 0.0038 0.1557 0.1696
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Onchocerca volvulus 0.0046 0.209 0.4518
Echinococcus granulosus Fibronectin type III 0.0046 0.209 0.2275
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0038 0.1557 0.1696
Schistosoma mansoni hypothetical protein 0.0038 0.1557 0.1557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.9184 0.9184
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0084 0.4625 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0023 0.0535 0.0582
Schistosoma mansoni hypothetical protein 0.0038 0.1557 0.1557
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0023 0.0535 0.0535
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.1557 0.3367
Loa Loa (eye worm) TK protein kinase 0.0019 0.0271 0.0585
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0084 0.4625 0.5036
Echinococcus multilocularis tyrosine kinase 0.0019 0.0271 0.0271
Echinococcus granulosus tyrosine protein kinase otk 0.0038 0.1557 0.1696
Schistosoma mansoni myosin-binding protein-related 0.0084 0.4625 0.4625
Onchocerca volvulus 0.0038 0.1557 0.3367
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0046 0.209 0.2275
Onchocerca volvulus 0.0038 0.1557 0.3367
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Trichomonas vaginalis conserved hypothetical protein 0.0015 0 0.5
Echinococcus granulosus titin 0.0038 0.1557 0.1696
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0038 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0038 0.1557 0.3367
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0535 0.0582
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0046 0.209 0.209
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Trichomonas vaginalis protein kinase atn1, putative 0.0015 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0535 0.0535
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Echinococcus granulosus roundabout 2 0.0084 0.4625 0.5036
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0019 0.0271 0.0295
Echinococcus multilocularis usherin 0.0046 0.209 0.209
Brugia malayi Animal haem peroxidase family protein 0.0038 0.1557 0.3367
Brugia malayi Protein kinase domain containing protein 0.0019 0.0271 0.0585
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0271 0.0585
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Plasmodium falciparum protein kinase, putative 0.0015 0 0.5
Loa Loa (eye worm) SRC-1 0.0023 0.0535 0.1156
Echinococcus granulosus titin 0.0084 0.4625 0.5036
Echinococcus multilocularis tyrosine protein kinase Abl 0.0023 0.0535 0.0535
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.4625 1
Plasmodium falciparum protein kinase, putative 0.0015 0 0.5
Schistosoma mansoni nephrin 0.0084 0.4625 0.4625
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3923 0.5
Trichomonas vaginalis TKL family protein kinase 0.0015 0 0.5
Brugia malayi Disorganized muscle protein 1 0.0038 0.1557 0.3367
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0046 0.209 0.209
Echinococcus granulosus Fibronectin type III domain containing protein 0.0046 0.209 0.2275
Trichomonas vaginalis conserved hypothetical protein 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.209 0.4518
Echinococcus multilocularis anosmin 1 0.0046 0.209 0.209

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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