Detailed information for compound 1383566

Basic information

Technical information
  • TDR Targets ID: 1383566
  • Name: N-tert-butyl-2-(4-methoxyphenyl)-2-[[2-[(4-me thyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]ace tyl]-phenylamino]acetamide
  • MW: 543.68 | Formula: C30H33N5O3S
  • H donors: 1 H acceptors: 4 LogP: 5.02 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)C(N(c1ccccc1)C(=O)CSc1nnc(n1C)c1ccccc1)C(=O)NC(C)(C)C
  • InChi: 1S/C30H33N5O3S/c1-30(2,3)31-28(37)26(21-16-18-24(38-5)19-17-21)35(23-14-10-7-11-15-23)25(36)20-39-29-33-32-27(34(29)4)22-12-8-6-9-13-22/h6-19,26H,20H2,1-5H3,(H,31,37)
  • InChiKey: OYZBGVVNVGWKLI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-tert-butyl-2-(4-methoxyphenyl)-2-[[2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-phenyl-amino]acetamide
  • N-tert-butyl-2-(4-methoxyphenyl)-2-[[2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)thio]-1-oxoethyl]-phenylamino]acetamide
  • N-tert-butyl-2-(4-methoxyphenyl)-2-[[2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)thio]acetyl]-phenyl-amino]acetamide
  • N-tert-butyl-2-(4-methoxyphenyl)-2-[2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]ethanoyl-phenyl-amino]ethanamide
  • SMR000172717
  • ASN 04060538
  • MLS000563232
  • N-tert-Butyl-2-(4-methoxy-phenyl)-2-{[2-(4-methyl-5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetyl]-phenyl-amino}-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0043 0.0282
Trypanosoma cruzi NIMA-related kinase, putative 0.0048 0.0043 0.3489
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0043 0.0052
Trypanosoma cruzi protein kinase, putative 0.0048 0.0043 0.3541
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus multilocularis protein tyrosine kinase 0.0048 0.0043 0.0052
Brugia malayi SH2 domain containing protein 0.0048 0.0043 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus multilocularis tyrosine kinase 0.0048 0.0043 0.0052
Trypanosoma cruzi NIMA-related kinase, putative 0.0048 0.0043 0.3489
Echinococcus granulosus tyrosine protein kinase 0.0048 0.0043 0.0052
Echinococcus multilocularis activated cdc42 kinase 1 0.0048 0.0043 0.0052
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0048 0.0043 0.3489
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Echinococcus granulosus semaphorin 5B 0.0301 0.1051 0.1258
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0048 0.0043 0.0052
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Echinococcus multilocularis tyrosine protein kinase pr2 0.0048 0.0043 0.0052
Echinococcus granulosus protein kinase 0.0048 0.0043 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0038 0.0001 0.0001
Loa Loa (eye worm) TK/Met protein kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) plexin A 0.084 0.3199 0.3199
Schistosoma mansoni serine/threonine-protein kinase 0.0048 0.0043 0.0041
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Trypanosoma brucei Pseudokinase, putative 0.0048 0.0043 0.3541
Loa Loa (eye worm) AUR protein kinase 0.0068 0.012 0.012
Trypanosoma cruzi protein kinase, putative 0.0048 0.0043 0.3541
Brugia malayi serine/threonine kinase 12 0.0068 0.012 0.012
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0048 0.0043 0.0052
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.013 0.0367 0.0367
Trypanosoma cruzi Protein kinase B 0.0048 0.0043 0.3489
Echinococcus granulosus kinase suppressor of Ras 1 0.0048 0.0043 0.0052
Loa Loa (eye worm) AGC/AKT protein kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0043 0.0052
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0048 0.0043 0.3489
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Echinococcus multilocularis oxysterol binding protein 1 0.0038 0.0001 0.0001
Echinococcus granulosus insulin receptor 0.0048 0.0043 0.0052
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0277
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0043 0.0052
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.012 1
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0043 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0043 0.0282
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0043 0.0052
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0048 0.0043 0.0043
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0043 0.0052
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0038 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Schistosoma mansoni serine/threonine-protein kinase 0.0048 0.0043 0.0041
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0048 0.0043 0.3489
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Loa Loa (eye worm) AUR protein kinase 0.0068 0.012 0.012
Brugia malayi Probable exocyst complex component Sec5 0.0132 0.0376 0.0376
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Echinococcus granulosus Pleckstrin y 0.0038 0.0001 0.0001
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0048 0.0043 0.0052
Echinococcus granulosus tyrosine kinase 0.0048 0.0043 0.0052
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0038 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Loa Loa (eye worm) oxysterol binding protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2133 0.8354 0.8354
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0048 0.0043 0.0052
Entamoeba histolytica tyrosin kinase, putative 0.018 0.0569 0.3801
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0043 0.0052
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0048 0.0043 0.0052
Echinococcus multilocularis axis inhibition protein axin 0.0413 0.1496 0.179
Entamoeba histolytica hypothetical protein 0.0413 0.1496 1
Loa Loa (eye worm) sema domain-containing protein 0.0301 0.1051 0.1051
Trichomonas vaginalis protein tyrosine kinase, putative 0.0048 0.0043 0.0282
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0048 0.0043 0.0042
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0043 0.0052
Entamoeba histolytica protein kinase, putative 0.0068 0.012 0.0795
Loa Loa (eye worm) TK/ACK protein kinase 0.0048 0.0043 0.0043
Echinococcus granulosus tyrosine protein kinase shark 0.0048 0.0043 0.0052
Echinococcus multilocularis hypothetical protein 0.0301 0.1051 0.1258
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Brugia malayi hypothetical protein 0.0413 0.1496 0.1496
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0132 0.0376 0.251
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.013 0.0367 0.0367
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus multilocularis oxysterol binding protein 9 0.0038 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Echinococcus granulosus roundabout 2 0.0134 0.0385 0.0461
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) protein kinase domain-containing protein 0.0048 0.0043 0.0043
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.013 0.0367 0.0366
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Entamoeba histolytica receptor protein kinase, putative 0.0048 0.0043 0.0282
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus granulosus neuroglian 0.013 0.0367 0.0439
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0038 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.013 0.0367 0.0367
Loa Loa (eye worm) AUR protein kinase 0.0068 0.012 0.012
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni protein kinase 0.0068 0.012 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Echinococcus multilocularis insulin receptor 0.0048 0.0043 0.0052
Onchocerca volvulus 0.0048 0.0043 0.0158
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0068 0.012 0.0795
Echinococcus granulosus calcium dependent secretion activator 1 0.0038 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0132 0.0376 0.0376
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0132 0.0376 0.251
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Brugia malayi Regulator of G protein signaling domain containing protein 0.0413 0.1496 0.1496
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus granulosus myotubularin protein 13 0.0038 0.0001 0.0001
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0043 0.0282
Echinococcus multilocularis roundabout 2 0.0134 0.0385 0.0461
Brugia malayi probable spectrin beta chain 0.0038 0.0001 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0301 0.1051 0.1051
Echinococcus granulosus beta-adrenergic receptor kinase 0.1951 0.763 0.9133
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Schistosoma mansoni hypothetical protein 0.0132 0.0376 0.0375
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0053 0.0062 0.0074
Echinococcus granulosus epidermal growth factor receptor 0.0048 0.0043 0.0052
Echinococcus multilocularis ephrin type A receptor 4 A 0.0048 0.0043 0.0052
Echinococcus granulosus beta 1 syntrophin 0.0038 0.0001 0.0001
Echinococcus multilocularis expressed protein 0.0413 0.1496 0.179
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0376 0.251
Onchocerca volvulus 0.0048 0.0043 0.0158
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Onchocerca volvulus 0.0048 0.0043 0.0158
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Echinococcus granulosus oxysterol binding protein 1 0.0038 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Plasmodium falciparum protein kinase, putative 0.0048 0.0043 0.3541
Loa Loa (eye worm) hypothetical protein 0.0413 0.1496 0.1496
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0048 0.0043 0.0052
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0048 0.0043 0.3489
Echinococcus granulosus fibroblast growth factor receptor 4 0.0048 0.0043 0.0052
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0048 0.0043 0.0052
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0043 0.0052
Echinococcus multilocularis oxysterol binding protein 3 0.0038 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0048 0.0043 0.3541
Loa Loa (eye worm) RGS-3 protein 0.0413 0.1496 0.1496
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0043 0.0052
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0048 0.0043 0.3489
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0038 0.0001 0.0001
Plasmodium falciparum tyrosine kinase-like protein 0.0048 0.0043 0.3541
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0048 0.0043 0.0052
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0048 0.0043 0.3489
Echinococcus multilocularis kinase suppressor of Ras 1 0.0048 0.0043 0.0052
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0038 0.0001 0.0001
Schistosoma mansoni ephrin receptor 0.0048 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Echinococcus granulosus tyrosine protein kinase pr2 0.0048 0.0043 0.0052
Echinococcus multilocularis Immunoglobulin 0.013 0.0367 0.0439
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0048 0.0043 0.0043
Echinococcus multilocularis receptor type guanylyl cyclase 0.0048 0.0043 0.0052
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0048 0.0043 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0043 0.0042
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0043 0.0052
Loa Loa (eye worm) hypothetical protein 0.0134 0.0385 0.0385
Echinococcus multilocularis Pleckstrin y 0.0038 0.0001 0.0001
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0413 0.1496 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus granulosus activated cdc42 kinase 1 0.0048 0.0043 0.0052
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0048 0.0043 0.0277
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0048 0.0043 0.0277
Echinococcus multilocularis tyrosine protein kinase HCK 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0043 0.0277
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/EPH protein kinase 0.0048 0.0043 0.0043
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0048 0.0043 0.0052
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/FAK protein kinase 0.0048 0.0043 0.0043
Echinococcus granulosus serine/threonine protein kinase 0.0048 0.0043 0.0051
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0059 0.0085 0.7031
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0277
Echinococcus multilocularis c src tyrosine kinase 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0413 0.1496 0.1496
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0048 0.0043 0.0042
Entamoeba histolytica p21-activated kinase 0.0048 0.0043 0.0277
Echinococcus granulosus tyrosine protein kinase Srms 0.0048 0.0043 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Echinococcus granulosus protein tyrosine kinase 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus granulosus tyrosine kinase 0.0048 0.0043 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0014 0.0013
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0043 0.0052
Echinococcus granulosus transcription factor collier 0.0132 0.0376 0.045
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.0043 0.0282
Echinococcus granulosus expressed protein 0.0413 0.1496 0.179
Entamoeba histolytica cysteine surface protein, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) sema domain-containing protein 0.0301 0.1051 0.1051
Brugia malayi hypothetical protein 0.0413 0.1496 0.1496
Brugia malayi Guanylyl cyclase protein 23 0.0048 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0413 0.1496 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.1051 0.1051
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0043 0.0052
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Echinococcus multilocularis dynamin 1 0.0038 0.0001 0.0001
Brugia malayi regulator of G-protein signaling egl-10 0.0413 0.1496 0.1496
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.012 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.0043 0.0042
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0301 0.1051 0.1051
Echinococcus multilocularis neuroglian 0.013 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0178 0.056 0.056
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Echinococcus multilocularis beta 1 syntrophin 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0048 0.0043 0.3489
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1539 0.5985 0.7164
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0413 0.1496 0.1495
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0277
Loa Loa (eye worm) hypothetical protein 0.0132 0.0376 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0376 0.251
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0043 0.0052
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0048 0.0043 0.0282
Brugia malayi Oxysterol-binding protein 0.0038 0.0001 0.0001
Entamoeba histolytica protein kinase , putative 0.0068 0.012 0.0795
Loa Loa (eye worm) TK/CSK protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Brugia malayi MAX-1A 0.0038 0.0001 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Brugia malayi hypothetical protein 0.0048 0.0043 0.0043
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.0043 0.0052
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2546 1 1
Echinococcus multilocularis transfer RNA-Thr 0.0048 0.0043 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0043 0.0282
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Brugia malayi TBC domain containing protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0048 0.0043 0.3541
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Schistosoma mansoni serine/threonine protein kinase 0.2546 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0376 0.251
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus multilocularis tyrosine kinase 0.0048 0.0043 0.0052
Echinococcus granulosus pleckstrin y domain containing family A 0.0038 0.0001 0.0001
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.0043 0.0282
Echinococcus multilocularis myotubularin protein 13 0.0038 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0376 0.251
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.0043 0.0043
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0048 0.0043 0.0043
Echinococcus multilocularis FL cytokine receptor 0.0048 0.0043 0.0052
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Entamoeba histolytica cell surface protease gp63, putative 0.0132 0.0376 0.251
Schistosoma mansoni protein kinase 0.0048 0.0043 0.0042
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0048 0.0043 0.3489
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Echinococcus granulosus DCC interacting protein 13 beta 0.0038 0.0001 0.0001
Brugia malayi Plexin repeat family protein 0.0708 0.2672 0.2672
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0277
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0132 0.0376 0.251
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0048 0.0043 0.3489
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0043 0.0282
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Echinococcus multilocularis integrin linked protein kinase 0.0048 0.0043 0.0052
Entamoeba histolytica hypothetical protein 0.0413 0.1496 1
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0038 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Echinococcus multilocularis aurora kinase A 0.0068 0.012 0.0143
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Schistosoma mansoni plexin 0.0708 0.2672 0.2672
Echinococcus granulosus GRB2 associated binding protein 3 0.0038 0.0001 0.0001
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0048 0.0043 0.0043
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0038 0.0001 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Echinococcus granulosus Immunoglobulin 0.013 0.0367 0.0439
Echinococcus granulosus cytohesin 1 0.0038 0.0001 0.0001
Echinococcus granulosus oxysterol binding protein 3 0.0038 0.0001 0.0001
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0277
Echinococcus granulosus aurora kinase A 0.0068 0.012 0.0143
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0048 0.0043 0.0158
Brugia malayi Fibronectin type III domain containing protein 0.0134 0.0385 0.0385
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0048 0.0043 0.0158
Plasmodium falciparum protein kinase, putative 0.0059 0.0085 0.7031
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Toxoplasma gondii protein kinase domain-containing protein 0.0048 0.0043 0.3489
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus granulosus twitchin 0.014 0.0408 0.0488
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0038 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0277
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica ankyrin repeat protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0134 0.0385 0.0385
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0048 0.0043 0.0052
Loa Loa (eye worm) hypothetical protein 0.013 0.0367 0.0367
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0048 0.0043 0.3489
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Echinococcus multilocularis regulator of G protein signaling 7 0.0413 0.1496 0.179
Brugia malayi Cadps2 protein 0.0038 0.0001 0.0001
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0043 0.0052
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Echinococcus multilocularis epidermal growth factor receptor 0.0048 0.0043 0.0052
Trichomonas vaginalis STE family protein kinase 0.0048 0.0043 0.0282
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Brugia malayi IPT/TIG domain containing protein 0.0132 0.0376 0.0376
Echinococcus granulosus axis inhibition protein axin 0.0413 0.1496 0.179
Onchocerca volvulus 0.0048 0.0043 0.0158
Brugia malayi Tyrosine-protein kinase PR2 0.0048 0.0043 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0014 0.0013
Loa Loa (eye worm) uncoordinated protein 104 0.0038 0.0001 0.0001
Leishmania major serine/threonine-protein kinase a, putative 0.0048 0.0043 0.3489
Schistosoma mansoni nephrin 0.0134 0.0385 0.0384
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0038 0.0001 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0048 0.0043 0.0052
Brugia malayi Furin-like cysteine rich region family protein 0.0048 0.0043 0.0043
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2133 0.8354 1
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Loa Loa (eye worm) hypothetical protein 0.0132 0.0376 0.0376
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0048 0.0043 0.0052
Trypanosoma brucei Flagellum attachment zone protein 20 0.0048 0.0043 0.3541
Brugia malayi Plekhf2 protein 0.0038 0.0001 0.0001
Echinococcus multilocularis basement membrane specific heparan sulfate 0.013 0.0367 0.0439
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0038 0.0001 0.0001
Brugia malayi Raf kinase 0.0048 0.0043 0.0043
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0048 0.0043 0.3489
Schistosoma mansoni serine/threonine protein kinase 0.1951 0.763 0.763
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0043 0.0052
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Trypanosoma brucei protein kinase, putative 0.0048 0.0043 0.3489
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.012 0.0795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase, putative 0.0068 0.012 0.0795
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0048 0.0043 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0068 0.012 0.0795
Leishmania major protein kinase, putative 0.0048 0.0043 0.3489
Echinococcus multilocularis protein kinase 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Leishmania major protein kinase, putative 0.0048 0.0043 0.3489
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Onchocerca volvulus Tyrosine kinase homolog 0.0048 0.0043 0.0158
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0043 0.0277
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0413 0.1496 1
Echinococcus granulosus Pleckstrin y 0.0038 0.0001 0.0001
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Onchocerca volvulus 0.0048 0.0043 0.0158
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Echinococcus multilocularis regulator of G protein signaling 3 0.0413 0.1496 0.179
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0277
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Brugia malayi ephrin receptor 1 precursor 0.0048 0.0043 0.0043
Brugia malayi DNA-binding protein LAG-1 0.0132 0.0376 0.0376
Brugia malayi PXA domain containing protein 0.0413 0.1496 0.1496
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0043 0.0052
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2133 0.8354 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0413 0.1496 0.1496
Echinococcus multilocularis tyrosine protein kinase Abl 0.0048 0.0043 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Leishmania major folate/biopterin transporter, putative 0.0048 0.0043 0.3489
Brugia malayi bone morphogenetic protein type 1 receptor 0.0048 0.0043 0.0043
Plasmodium falciparum protein kinase, putative 0.0048 0.0043 0.3541
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0048 0.0043 0.0282
Echinococcus granulosus pdz domain containing protein 0.0038 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0413 0.1496 1
Entamoeba histolytica hypothetical protein 0.0132 0.0376 0.251
Loa Loa (eye worm) SRC-1 0.0048 0.0043 0.0043
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0059 0.0085 0.7031
Echinococcus multilocularis rac serine:threonine kinase 0.0048 0.0043 0.0051
Echinococcus multilocularis calcium dependent secretion activator 1 0.0038 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Echinococcus granulosus Pleckstrin y 0.0038 0.0001 0.0001
Brugia malayi C-terminal src kinase protein 1 0.0048 0.0043 0.0043
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0038 0.0001 0.0001
Echinococcus multilocularis regulator of G protein signaling 0.0413 0.1496 0.179
Echinococcus multilocularis tyrosine protein kinase shark 0.0048 0.0043 0.0052
Loa Loa (eye worm) hypothetical protein 0.013 0.0367 0.0367
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0038 0.0001 0.0001
Leishmania major protein kinase, putative 0.0059 0.0085 0.7031
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Echinococcus granulosus exocyst complex component 2 0.0132 0.0376 0.045
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0043 0.0052
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0043 0.0052
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0038 0.0001 0.0001
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0048 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0132 0.0376 0.0375
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0068 0.012 0.0795
Schistosoma mansoni regulator of G protein signaling 0.0413 0.1496 0.1495
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0048 0.0043 0.3489
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0043 0.0277
Echinococcus multilocularis protein kinase 0.0048 0.0043 0.0052
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Plasmodium falciparum tyrosine kinase-like protein 0.0048 0.0043 0.3541
Loa Loa (eye worm) serine/threonine protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0048 0.0043 0.0282
Echinococcus multilocularis raf serine:threonine protein kinase 0.0048 0.0043 0.0052
Echinococcus multilocularis tyrosine protein kinase 0.0048 0.0043 0.0052
Schistosoma mansoni protein kinase 0.0048 0.0043 0.0042
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Echinococcus multilocularis regulator of G protein signaling 7 0.0413 0.1496 0.179
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.0043 0.0052
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0001 0.0001
Echinococcus granulosus regulator of G protein signaling 3 0.0413 0.1496 0.179
Entamoeba histolytica receptor protein kinase, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0301 0.1051 0.1051
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Brugia malayi Tyrosine-protein kinase abl-1 0.0048 0.0043 0.0043
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.0043 0.0052
Brugia malayi hypothetical protein 0.0038 0.0001 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Brugia malayi Uncoordinated protein 104 0.0038 0.0001 0.0001
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0038 0.0001 0.0001
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0048 0.0043 0.0052
Echinococcus granulosus axis inhibition protein axin 0.0413 0.1496 0.179
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0376 0.251
Schistosoma mansoni ephrin receptor 0.0053 0.0062 0.0061
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0043 0.0052
Brugia malayi Syntrophin-1 0.0038 0.0001 0.0001
Echinococcus granulosus plexin a4 0.084 0.3199 0.3829
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0413 0.1496 0.1495
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0059 0.0085 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.0043 0.0282
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0043 0.0282
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Entamoeba histolytica ankyrin repeat protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0038 0.0001 0.0001
Schistosoma mansoni protein kinase 0.0048 0.0043 0.0042
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2133 0.8354 0.8354
Loa Loa (eye worm) TK/EGFR protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0043 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0376 0.251
Loa Loa (eye worm) hypothetical protein 0.0708 0.2672 0.2672
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Brugia malayi Regulator of G protein signaling domain containing protein 0.0413 0.1496 0.1496
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Brugia malayi serine/threonine protein kinase 6 0.0068 0.012 0.012
Schistosoma mansoni cell adhesion molecule 0.0134 0.0385 0.0384
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.012 0.0143
Loa Loa (eye worm) hypothetical protein 0.0413 0.1496 0.1496
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0043 0.0042
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Brugia malayi hypothetical protein 0.0301 0.1051 0.1051
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0043 0.0277
Echinococcus granulosus integrin linked protein kinase 0.0048 0.0043 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0301 0.1051 0.1051
Echinococcus multilocularis GRB2 associated binding protein 3 0.0038 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0282
Echinococcus granulosus tyrosine protein kinase HCK 0.0048 0.0043 0.0052
Echinococcus multilocularis Ras associated and pleckstrin y 0.0038 0.0001 0.0001
Brugia malayi integrin-linked kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0048 0.0043 0.0042
Brugia malayi regulator of G-protein signaling rgs-7 0.0413 0.1496 0.1496
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/ALK protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Schistosoma mansoni Neurotrimin precursor (hNT) 0.013 0.0367 0.0366
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Plasmodium vivax protein kinase, putative 0.0048 0.0043 0.3541
Giardia lamblia Aurora kinase 0.0068 0.012 1
Echinococcus granulosus epidermal growth factor receptor 0.0048 0.0043 0.0052
Loa Loa (eye worm) hypothetical protein 0.0134 0.0385 0.0385
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Brugia malayi serine/threonine-protein kinase 6 0.0068 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0068 0.012 0.0795
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/RYK protein kinase 0.0048 0.0043 0.0043
Onchocerca volvulus 0.0048 0.0043 0.0158
Schistosoma mansoni tyrosine protein kinase 0.0048 0.0043 0.0042
Echinococcus granulosus receptor type guanylyl cyclase 0.0048 0.0043 0.0052
Echinococcus multilocularis pleckstrin y domain containing family A 0.0038 0.0001 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0134 0.0385 0.0385
Schistosoma mansoni z-protein (S1r protein) 0.0413 0.1496 0.1495
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Echinococcus granulosus G protein coupled receptor kinase 1 0.1539 0.5985 0.7164
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.0043 0.0052
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0048 0.0043 0.3489
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0413 0.1496 0.179
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0043 0.0052
Onchocerca volvulus 0.0048 0.0043 0.0158
Schistosoma mansoni axis inhibition protein axin 0.0413 0.1496 0.1495
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0043 0.0277
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.013 0.0367 0.0367
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Echinococcus multilocularis pdz domain containing protein 0.0038 0.0001 0.0001
Trichomonas vaginalis protein kinase atn1, putative 0.0048 0.0043 0.0282
Echinococcus multilocularis natriuretic peptide receptor 1 0.0048 0.0043 0.0052
Echinococcus multilocularis protein KINase family member (kin 25) 0.0048 0.0043 0.0052
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Onchocerca volvulus 0.0048 0.0043 0.0158
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0048 0.0043 0.0282
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Entamoeba histolytica hypothetical protein 0.0132 0.0376 0.251
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0038 0.0001 0.0001
Echinococcus granulosus tyrosine protein kinase ABL1 0.0048 0.0043 0.0052
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Echinococcus granulosus ephrin type A receptor 4 A 0.0048 0.0043 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0059 0.0085 0.7031
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Echinococcus granulosus Oxysterol binding protein 11 0.0038 0.0001 0.0001
Brugia malayi Sema domain containing protein 0.0301 0.1051 0.1051
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0048 0.0043 0.3541
Onchocerca volvulus 0.0048 0.0043 0.0158
Loa Loa (eye worm) rho-GTPase-activating 0.0038 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.0043 0.0052
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2133 0.8354 0.8354
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0277
Echinococcus multilocularis heat shock protein 70 0.0048 0.0043 0.0052
Onchocerca volvulus 0.0301 0.1051 0.393
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Schistosoma mansoni axis inhibition protein axin 0.0413 0.1496 0.1495
Schistosoma mansoni fibrocystin l 0.0132 0.0376 0.0375
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0413 0.1496 0.1496
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni protein kinase 0.0059 0.0085 0.0084
Onchocerca volvulus 0.0048 0.0043 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0043 0.0282
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0043 0.0052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0178 0.056 0.056
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni protein kinase 0.0059 0.0085 0.0084
Loa Loa (eye worm) cytohesin 3 0.0038 0.0001 0.0001
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.0043 0.0052
Brugia malayi hypothetical protein 0.0048 0.0043 0.0043
Echinococcus granulosus oxysterol binding protein 9 0.0038 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0038 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0068 0.012 0.0795
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0048 0.0043 0.0042
Echinococcus multilocularis actin binding protein anillin 0.0038 0.0001 0.0001
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0048 0.0043 0.0042
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.012 0.0119
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Brugia malayi A-kinase anchor protein 10, precursor 0.0413 0.1496 0.1496
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0048 0.0043 0.0043
Echinococcus multilocularis Pleckstrin y 0.0038 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0376 0.251
Schistosoma mansoni protein kinase 0.0048 0.0043 0.0042
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0043 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Brugia malayi Sema domain containing protein 0.0301 0.1051 0.1051
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0413 0.1496 0.1495
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Schistosoma mansoni protein kinase 0.0059 0.0085 0.0084
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus granulosus regulator of G protein signaling 3 0.0413 0.1496 0.179
Entamoeba histolytica PH domain containing protein kinase, putative 0.0048 0.0043 0.0277
Echinococcus granulosus tyrosine protein kinase Lyn 0.0059 0.0085 0.0101
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Brugia malayi hypothetical protein 0.0301 0.1051 0.1051
Brugia malayi PXA domain containing protein 0.0413 0.1496 0.1496
Schistosoma mansoni protein kinase 0.0048 0.0043 0.0042
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0048 0.0043 0.3489
Echinococcus multilocularis regulator of G protein signaling 3 0.0413 0.1496 0.179
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Brugia malayi hypothetical protein 0.0048 0.0043 0.0043
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.0043 0.0052
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0048 0.0043 0.0043
Leishmania major protein kinase, putative 0.0068 0.012 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0043 0.0052
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.0043 0.0282
Brugia malayi Dynamin 0.0038 0.0001 0.0001
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0413 0.1496 0.179
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Entamoeba histolytica hypothetical protein 0.0413 0.1496 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Brugia malayi Pleckstrin Homology Domain 0.0038 0.0001 0.0001
Echinococcus granulosus raf serine:threonine protein kinase 0.0048 0.0043 0.0052
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0038 0.0001 0.0001
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0068 0.012 0.0795
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0043 0.0042
Toxoplasma gondii protein kinase domain-containing protein 0.0048 0.0043 0.3541
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus multilocularis activin receptor type 0.0059 0.0085 0.0101
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0043 0.0052
Brugia malayi hypothetical protein 0.0134 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0413 0.1496 0.1496
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Echinococcus granulosus natriuretic peptide receptor 1 0.0048 0.0043 0.0052
Echinococcus multilocularis DCC interacting protein 13 beta 0.0038 0.0001 0.0001
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Brugia malayi Dynamin 0.0038 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.012 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0038 0.0001 0.0001
Leishmania major protein kinase, putative 0.0048 0.0043 0.3541
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0048 0.0043 0.0052
Echinococcus granulosus c src tyrosine kinase 0.0048 0.0043 0.0052
Echinococcus multilocularis Rho GTPase activating protein 24 0.0038 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus granulosus semaphorin 1A 0.0301 0.1051 0.1258
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0413 0.1496 0.1496
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0048 0.0043 0.3489
Loa Loa (eye worm) PH domain-containing protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Schistosoma mansoni protein kinase 0.0048 0.0043 0.0042
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Onchocerca volvulus 0.0048 0.0043 0.0158
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Echinococcus granulosus defective proboscis extension response 0.013 0.0367 0.0439
Entamoeba histolytica hypothetical protein 0.0132 0.0376 0.251
Entamoeba histolytica hypothetical protein 0.0048 0.0043 0.0282
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0132 0.0376 0.251
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) TK/DDR protein kinase 0.0048 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Plasmodium falciparum calcium-dependent protein kinase 7 0.0048 0.0043 0.3489
Brugia malayi PH domain containing protein 0.0038 0.0001 0.0001
Echinococcus multilocularis exocyst complex component 2 0.0132 0.0376 0.045
Toxoplasma gondii aurora kinase 0.0068 0.012 1
Onchocerca volvulus 0.0048 0.0043 0.0158
Brugia malayi Cytohesin 3 0.0038 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0407 0.1472 0.1471
Loa Loa (eye worm) hypothetical protein 0.0048 0.0043 0.0043
Loa Loa (eye worm) PXA domain-containing protein 0.0413 0.1496 0.1496
Schistosoma mansoni protein kinase 0.0048 0.0043 0.0042
Plasmodium vivax tyrosine kinase-like protein, putative 0.0048 0.0043 0.3541
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0059 0.0085 0.0101
Brugia malayi Oxysterol binding protein 0.0038 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0043 0.0052
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0413 0.1496 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Schistosoma mansoni plexin 0.0407 0.1472 0.1471
Echinococcus granulosus activin receptor type 0.0059 0.0085 0.0101
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1951 0.763 0.763
Brugia malayi SH2 domain containing protein 0.0048 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0301 0.1051 0.105
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.0043 0.0052
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.0043 0.0282
Schistosoma mansoni regulator of G protein signaling 0.0413 0.1496 0.1495
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Brugia malayi SRC-1 0.0048 0.0043 0.0043
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0048 0.0043 0.0282
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0048 0.0043 0.3489
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0413 0.1496 1
Echinococcus granulosus dynamin 1 0.0038 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Echinococcus multilocularis epidermal growth factor receptor 0.0048 0.0043 0.0052
Loa Loa (eye worm) hypothetical protein 0.0132 0.0376 0.0376
Entamoeba histolytica protein kinase, putative 0.0048 0.0043 0.0282
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Loa Loa (eye worm) Plekhf2 protein 0.0038 0.0001 0.0001
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0048 0.0043 0.0052
Schistosoma mansoni protein tyrosine kinase 0.0048 0.0043 0.0042
Loa Loa (eye worm) syntrophin-1 0.0038 0.0001 0.0001
Echinococcus multilocularis Immunoglobulin 0.013 0.0367 0.0439
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0038 0.0001 0.0001
Echinococcus multilocularis cytohesin 1 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Trypanosoma brucei protein kinase, putative 0.0059 0.0085 0.7031
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Echinococcus multilocularis plexin a4 0.084 0.3199 0.3829
Onchocerca volvulus 0.0048 0.0043 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0413 0.1496 1
Entamoeba histolytica hypothetical protein 0.0132 0.0376 0.251
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Echinococcus multilocularis beta adrenergic receptor kinase 0.1951 0.763 0.9133
Toxoplasma gondii protein kinase 0.0048 0.0043 0.3541
Onchocerca volvulus 0.0048 0.0043 0.0158
Schistosoma mansoni regulator of G protein signaling 0.0413 0.1496 0.1495
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0059 0.0085 0.7031
Schistosoma mansoni serine/threonine RGC 0.0048 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0301 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0407 0.1472 0.1472
Schistosoma mansoni semaphorin 5-related 0.0301 0.1051 0.105
Echinococcus granulosus Regulator of G protein signaling 20 0.0413 0.1496 0.179
Trypanosoma brucei aurora B kinase 0.0068 0.012 1
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Schistosoma mansoni regulator of G protein signaling 0.0413 0.1496 0.1495
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trypanosoma brucei rac serine-threonine kinase, putative 0.0048 0.0043 0.3489
Onchocerca volvulus 0.0708 0.2672 1
Toxoplasma gondii STE kinase 0.0048 0.0043 0.3541
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0048 0.0043 0.3541
Brugia malayi Protein kinase domain containing protein 0.0048 0.0043 0.0043
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.012 0.0143
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0048 0.0043 0.3489
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Echinococcus granulosus regulator of G protein signaling 7 0.0413 0.1496 0.179
Echinococcus granulosus tyrosine kinase 0.0048 0.0043 0.0052
Echinococcus multilocularis transcription factor collier 0.0132 0.0376 0.045
Trichomonas vaginalis TK family protein kinase 0.0048 0.0043 0.0282
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0043 0.0277
Schistosoma mansoni vesicular amine transporter 0.0132 0.0376 0.0375
Echinococcus multilocularis semaphorin 5B 0.0301 0.1051 0.1258
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.1951 0.763 0.763
Schistosoma mansoni protein kinase 0.0048 0.0043 0.0042
Plasmodium vivax tyrosine kinase-like protein, putative 0.0048 0.0043 0.3541
Onchocerca volvulus 0.0048 0.0043 0.0158
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0038 0.0001 0.0001
Echinococcus multilocularis Pleckstrin y 0.0038 0.0001 0.0001
Schistosoma mansoni regulator of G protein signaling 0.0413 0.1496 0.1495
Brugia malayi plexin A 0.084 0.3199 0.3199
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0085 0.0559
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trichomonas vaginalis AGC family protein kinase 0.0068 0.012 0.0795
Loa Loa (eye worm) TK protein kinase 0.0048 0.0043 0.0043
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.0043 0.0052
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0132 0.0376 0.251
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0043 0.0282
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Brugia malayi protein-tyrosine kinase 0.0048 0.0043 0.0043
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.0043 0.0282
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.013 0.0367 0.0439
Schistosoma mansoni hypothetical protein 0.0048 0.0043 0.0042
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0048 0.0043 0.0043
Echinococcus multilocularis Regulator of G protein signaling 20 0.0413 0.1496 0.179
Echinococcus granulosus regulator of G protein signaling 7 0.0413 0.1496 0.179
Echinococcus granulosus activated cdc42 kinase 1 0.0048 0.0043 0.0052
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Schistosoma mansoni tyrosine kinase 0.0048 0.0043 0.0042
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0053 0.0062 0.0074
Schistosoma mansoni hypothetical protein 0.0301 0.1051 0.105
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0048 0.0043 0.0052
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0048 0.0043 0.0043
Echinococcus multilocularis Oxysterol binding protein 11 0.0038 0.0001 0.0001
Echinococcus granulosus Rho GTPase activating protein 24 0.0038 0.0001 0.0001
Loa Loa (eye worm) TK/ABL protein kinase 0.0048 0.0043 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.018 0.0569 0.3801
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0043 0.0282
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0043 0.0282
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0048 0.0043 0.0043
Echinococcus multilocularis axis inhibition protein axin 0.0413 0.1496 0.179

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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