Detailed information for compound 1384349

Basic information

Technical information
  • TDR Targets ID: 1384349
  • Name: 3-(3-methylphenyl)-5-(phenylsulfanylmethyl)-1 ,2,4-oxadiazole
  • MW: 282.36 | Formula: C16H14N2OS
  • H donors: 0 H acceptors: 2 LogP: 4.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)c1noc(n1)CSc1ccccc1
  • InChi: 1S/C16H14N2OS/c1-12-6-5-7-13(10-12)16-17-15(19-18-16)11-20-14-8-3-2-4-9-14/h2-10H,11H2,1H3
  • InChiKey: UKKMSDNUYOWQPO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(3-methylphenyl)-5-[(phenylthio)methyl]-1,2,4-oxadiazole
  • MLS000534840
  • SMR000142276
  • ZINC00471623

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis protein dispatched 1 0.0058 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0532 0.3066 0.559
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0622 0.3626 0.3626
Entamoeba histolytica hypothetical protein 0.0112 0.043 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.4312 0.7898
Trichomonas vaginalis PIKK family atypical protein kinase 0.0606 0.3527 0.6444
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0112 0.043 0.4221
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0281 0.1492 0.1492
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0825 0.0825
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0232 0.0208
Giardia lamblia Phosphatidylinositol 4-kinase 0.0112 0.043 0.0771
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0017 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0363 0.2007 0.3684
Loa Loa (eye worm) hypothetical protein 0.0136 0.0579 0.0598
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.048 0.2738 0.4951
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0112 0.043 0.04
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0726 0.4281 0.6361
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0112 0.043 0.0892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0532 0.3066 0.559
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1117 0.673 0.673
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0112 0.043 0.0312
Trypanosoma cruzi hypothetical protein, conserved 0.0104 0.0383 0.0239
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0888 0.5299 0.5299
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0912 0.5447 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0763 0.4511 0.8266
Trichomonas vaginalis conserved hypothetical protein 0.0311 0.1676 0.3017
Leishmania major phosphatidylinositol 3-kinase, putative 0.048 0.2738 0.4951
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.043 0.0709
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0112 0.043 0.04
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0281 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.0286 0.1518 0.1653
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0093 0.0138
Loa Loa (eye worm) hypothetical protein 0.0119 0.0473 0.0478
Brugia malayi hypothetical protein 0.0286 0.1518 0.2256
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0195 0.0951 0.2113
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0363 0.2007 0.3684
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0363 0.2007 0.2736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0763 0.4511 0.8266
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.1492 0.2217
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0363 0.2007 0.3628
Entamoeba histolytica hypothetical protein 0.0112 0.043 0.079
Entamoeba histolytica hypothetical protein 0.0744 0.4391 0.8062
Echinococcus multilocularis expressed conserved protein 0.0112 0.0428 0.0428
Schistosoma mansoni hypothetical protein 0.0164 0.0758 0.0758
Entamoeba histolytica hypothetical protein 0.0112 0.043 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0763 0.4511 0.8266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.1215 0.2163
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0789 0.1374
Echinococcus multilocularis serine protein kinase ATM 0.0281 0.1492 0.1492
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0195 0.0951 0.1112
Giardia lamblia Hypothetical protein 0.0112 0.043 0.0771
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0112 0.043 0.043
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0195 0.0951 0.0951
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0195 0.0951 0.2113
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0912 0.5447 0.8093
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0654 0.3828 0.7002
Loa Loa (eye worm) hypothetical protein 0.0199 0.0974 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.0974 0.1715
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1117 0.673 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0888 0.5299 0.9726
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0195 0.0951 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0417 0.2344 0.4303
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0112 0.043 0.0312
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0888 0.5299 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0763 0.4511 0.8266
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0363 0.2007 0.2982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.3523 0.6438
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0281 0.1492 0.1945
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0112 0.043 0.0312
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0363 0.2007 0.3508
Loa Loa (eye worm) hypothetical protein 0.0062 0.0119 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0606 0.3527 0.6444
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0311 0.1676 0.3816
Echinococcus granulosus expressed conserved protein 0.0112 0.0428 0.0428
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0763 0.4514 0.8452
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0616 0.359 0.663
Brugia malayi FAT domain containing protein 0.0199 0.0974 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.3523 0.6438
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0195 0.0951 0.0951
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1638 1 1
Leishmania major hypothetical protein, conserved 0.0217 0.1086 0.1692
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0048 0.0048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0622 0.3626 0.5387
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0195 0.0951 0.1426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.4312 0.7898
Schistosoma mansoni hypothetical protein 0.0164 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0169 0.0789 0.0834
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0112 0.043 0.043
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0199 0.0974 0.0974
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0227 0.0227
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0622 0.3626 0.3626
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0912 0.5447 0.8027
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0363 0.2004 0.3503
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0195 0.0951 0.0951
Plasmodium vivax hypothetical protein 0.0112 0.043 0.4221
Leishmania major phosphatidylinositol kinase, putative 0.0112 0.043 0.04
Onchocerca volvulus 0.0112 0.043 1
Loa Loa (eye worm) hypothetical protein 0.029 0.1549 0.1688
Schistosoma mansoni hypothetical protein 0.0112 0.043 0.043
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0363 0.2007 0.3628
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0793 0.0793
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1117 0.673 0.673
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0485 0.2772 0.521
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0112 0.043 0.064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0112 0.043 0.064
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0473 0.0473
Loa Loa (eye worm) phosphatidylinositol 3 0.0616 0.359 0.3982
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0912 0.5447 0.8027
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0195 0.0951 0.1746
Loa Loa (eye worm) hypothetical protein 0.0281 0.1492 0.1624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.1492 0.2676
Echinococcus multilocularis geminin 0.0164 0.0758 0.0758
Echinococcus multilocularis protein patched 0.0051 0.0048 0.0048
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0112 0.043 0.043
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1117 0.673 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.005 0.005
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.048 0.2738 0.4984
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0112 0.043 0.4389
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0112 0.043 0.043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0888 0.5299 0.7874
Loa Loa (eye worm) phosphatidylinositol kinase 0.0112 0.043 0.043
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0888 0.5299 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0417 0.2344 0.4253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.4312 0.7898
Schistosoma mansoni hypothetical protein 0.0199 0.0974 0.0974
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0199 0.0974 0.0974
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0169 0.0789 0.0864
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0912 0.5447 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0731 0.4312 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0763 0.4511 0.8266
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0825 0.1226
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0888 0.5299 0.5299
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0112 0.043 0.043
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0136 0.0579 0.0598
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0363 0.2007 0.3628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0593 0.3449 0.6299
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.1304 0.1412
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0912 0.5447 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0281 0.1492 0.1492
Trypanosoma cruzi target of rapamycin kinase 3 0.0763 0.4514 0.6592
Trichomonas vaginalis PIKK family atypical protein kinase 0.069 0.4053 0.7418
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0112 0.043 0.0709
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0112 0.043 0.0892
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1638 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0112 0.043 0.043
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0023 0.0043
Toxoplasma gondii FATC domain-containing protein 0.0281 0.1492 0.3384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.4312 0.7898
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0195 0.0951 0.1673
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.005 0.0005
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0112 0.043 0.4389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.4312 0.7898
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0281 0.1492 0.1945
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0195 0.0951 0.1112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0888 0.5299 0.9726
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0616 0.359 0.663
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.1492 0.2217
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0112 0.043 0.079
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0195 0.0951 0.1673
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0112 0.043 0.043
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0036
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0888 0.5299 0.7799
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0473 0.0473
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0453 0.257 0.4718
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0485 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.048 0.2738 0.4984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0888 0.5299 0.9726
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.005 0.0005
Leishmania major phosphatidylinositol 3-kinase, putative 0.0195 0.0951 0.1426
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0112 0.043 0.4221
Mycobacterium tuberculosis Conserved hypothetical protein 0.0112 0.043 0.5
Schistosoma mansoni patched 1 0.0051 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0281 0.1492 0.274
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0227 0.0202
Giardia lamblia GTOR 0.0888 0.5299 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0195 0.0951 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.4312 0.7898
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0251 0.1304 0.1655
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0744 0.4391 0.8062
Trichomonas vaginalis PIKK family atypical protein kinase 0.048 0.2738 0.4984
Onchocerca volvulus 0.0112 0.043 1
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0638 0.3726 0.6812
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0195 0.0951 0.1015
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.028 0.1486 0.2773
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1117 0.673 0.673
Loa Loa (eye worm) acetyltransferase 0.0175 0.0825 0.0874
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0195 0.0951 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0564 0.3265 0.5958
Echinococcus granulosus geminin 0.0164 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0622 0.3626 0.4022
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0195 0.0951 0.0951
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0793 0.0793
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0227 0.0418
Loa Loa (eye worm) hypothetical protein 0.0112 0.043 0.043
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.08 0.4744 0.871
Leishmania major phosphatidylinositol 4-kinase, putative 0.0112 0.043 0.04
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0195 0.0951 1
Brugia malayi CHE-14 protein 0.0051 0.0048 0.0071
Loa Loa (eye worm) phosphatidylinositol 3 0.147 0.8944 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1117 0.673 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0227 0.0227
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0654 0.3828 0.7002
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0281 0.1492 0.2494
Schistosoma mansoni hypothetical protein 0.0058 0.0093 0.0093
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0195 0.0951 0.1426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0606 0.3527 0.6444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0363 0.2007 0.2007
Entamoeba histolytica protein kinase rad3, putative 0.0281 0.1492 0.274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.043 0.0709
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0112 0.043 0.064
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0794 0.0794
Brugia malayi Cytochrome P450 family protein 0.008 0.0232 0.0345
Echinococcus multilocularis Zinc finger, PHD finger 0.0195 0.0951 0.0951
Loa Loa (eye worm) hypothetical protein 0.0311 0.1676 0.1831
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0436 0.2465 0.4411
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0888 0.5299 1
Echinococcus granulosus serine protein kinase ATM 0.0281 0.1492 0.1492
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0227 0.0338
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0281 0.1492 0.1492
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0112 0.043 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0532 0.3066 0.559
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0112 0.043 0.4221
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0763 0.4514 0.8452
Loa Loa (eye worm) phosphatidylinositol 3 0.0888 0.5299 0.5903
Loa Loa (eye worm) phosphatidylinositol 3 0.0112 0.043 0.043
Loa Loa (eye worm) phosphatidylinositol 3 0.0112 0.043 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.4312 0.7898
Loa Loa (eye worm) hypothetical protein 0.0125 0.0513 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.048 0.2738 0.4984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0638 0.3726 0.6812
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5868 0.5868
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0112 0.043 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.3523 0.6438
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1518 0.1518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0169 0.0789 0.1374
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0473 0.0869
Mycobacterium leprae conserved hypothetical protein 0.0112 0.043 0.5
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0407 0.2279 0.2279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0606 0.3527 0.6444
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0112 0.043 0.4221
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0888 0.5299 0.9728
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0112 0.043 0.0312
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0888 0.5299 0.7799
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0407 0.2279 0.2279
Leishmania major hypothetical protein, unknown function 0.0112 0.043 0.04
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0888 0.5299 0.5299
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0825 0.0825
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0195 0.0951 0.1673
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0195 0.0951 0.1746
Echinococcus multilocularis 0.0112 0.043 0.043
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0888 0.5299 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0473 0.0703
Schistosoma mansoni hypothetical protein 0.0049 0.0036 0.0036
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0112 0.043 0.0312
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0888 0.5299 0.9728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.359 0.6561
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0912 0.5447 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0112 0.043 0.043
Loa Loa (eye worm) phosphatidylinositol 3 0.0112 0.043 0.043
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0112 0.043 0.0892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.1492 0.2676
Schistosoma mansoni survival motor neuron protein 0.0058 0.0093 0.0093
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0048 0.0048
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1518 0.1518
Leishmania major phosphatidylinositol kinase related protein, putative 0.0112 0.043 0.04

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.5283 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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