Detailed information for compound 139432

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.415 | Formula: C17H18N4O3S
  • H donors: 3 H acceptors: 3 LogP: 3.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccc2c(c1)[nH]c(c2/N=N\c1ccc(cc1)S(=O)(=O)N)O)C
  • InChi: 1S/C17H18N4O3S/c1-10(2)11-3-8-14-15(9-11)19-17(22)16(14)21-20-12-4-6-13(7-5-12)25(18,23)24/h3-10,19,22H,1-2H3,(H2,18,23,24)/b21-20+
  • InChiKey: BXOSDELNTKJOFY-QZQOTICOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.016 0.0151 0.0296
Schistosoma mansoni hypothetical protein 0.0353 0.0378 0.075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.002 0.0018
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0967 0.1102 0.371
Brugia malayi Animal haem peroxidase family protein 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0056 0.0182
Trypanosoma brucei unspecified product 0.016 0.0151 0.6835
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.002 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0464 0.051 0.0508
Schistosoma mansoni tar DNA-binding protein 0.0454 0.0497 0.0986
Loa Loa (eye worm) MBCTL1 0.0054 0.0026 0.0082
Brugia malayi MH1 domain containing protein 0.0174 0.0167 0.0558
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0101 0.4173
Trypanosoma brucei hypothetical protein, conserved 0.0217 0.0219 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0174 0.0167 0.0558
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.002 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0056 0.7781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0022 0.0024
Entamoeba histolytica hypothetical protein 0.0551 0.0612 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.002 0.006
Echinococcus multilocularis peroxidasin 0.0048 0.002 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.1115 0.1276 0.4299
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0188 0.0185 0.0363
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1115 0.1276 0.4299
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0053
Loa Loa (eye worm) hypothetical protein 0.0219 0.0221 0.0738
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.0056 0.0075
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0454 0.0497 0.1671
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.002 0.006
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.002 0.006
Schistosoma mansoni ras GTP exchange factor 0.0033 0.0002 0.0004
Leishmania major DNA polymerase kappa, putative 0.016 0.0151 0.6835
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.002 0.0018
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0009 0.0113
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0005 0.0005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.002 0.0018
Schistosoma mansoni hypothetical protein 0.0353 0.0378 0.075
Leishmania major hypothetical protein, conserved 0.0047 0.0019 0.0619
Schistosoma mansoni dep domain containing protein 0.0047 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi mothers against decapentaplegic homolog 3 0.0078 0.0054 0.0176
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0353 0.0378 0.0376
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0013 0.0026
Echinococcus multilocularis fetal alzheimer antigen, falz 0.007 0.0045 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0021 0.0892
Loa Loa (eye worm) latrophilin receptor protein 2 0.0353 0.0378 0.127
Brugia malayi Bromodomain containing protein 0.0236 0.024 0.0805
Echinococcus granulosus serotonin receptor 0.0048 0.002 0.0036
Echinococcus granulosus regulator of G protein signaling 7 0.0047 0.0018 0.0031
Brugia malayi larval opioid receptor 0.0048 0.002 0.006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0129 0.0252
Giardia lamblia DNA damage repair protein 0.005 0.0021 0.0875
Toxoplasma gondii hypothetical protein 0.0047 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0087 0.3567
Onchocerca volvulus 0.0048 0.002 0.0166
Schistosoma mansoni smad 0.0078 0.0054 0.0108
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.0056 0.7901
Echinococcus multilocularis snurportin 1 0.0967 0.1102 0.11
Brugia malayi TAR-binding protein 0.0454 0.0497 0.1671
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.002 0.0036
Onchocerca volvulus 0.0048 0.002 0.0166
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0174 0.0167 0.0328
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.002 0.0039
Schistosoma mansoni hypothetical protein 0.0047 0.0019 0.0037
Onchocerca volvulus 0.0048 0.002 0.0166
Schistosoma mansoni smad 0.0174 0.0167 0.0332
Leishmania major hypothetical protein, conserved 0.0079 0.0056 0.2373
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.002 0.0036
Echinococcus granulosus fmrfamide receptor 0.0048 0.002 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Schistosoma mansoni tar DNA-binding protein 0.0454 0.0497 0.0986
Brugia malayi Animal haem peroxidase family protein 0.0048 0.002 0.006
Echinococcus granulosus neuropeptide receptor 0.0048 0.002 0.0036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0111 0.0094 0.0092
Brugia malayi hypothetical protein 0.0047 0.0018 0.0053
Brugia malayi ORL1-like opioid receptor 0.0048 0.002 0.006
Trichomonas vaginalis importin beta-1, putative 0.0073 0.0049 0.317
Schistosoma mansoni hypothetical protein 0.0762 0.0861 0.1707
Brugia malayi G-protein coupled receptor 0.0048 0.002 0.006
Trypanosoma brucei ISWI complex protein 0.0047 0.0019 0.0619
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0067 0.0041 0.0133
Echinococcus multilocularis tar DNA binding protein 0.0454 0.0497 0.0495
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.002 0.0036
Leishmania major GTP-binding protein, putative 0.0067 0.0041 0.1684
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.002 0.006
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.002 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1115 0.1276 0.4299
Brugia malayi Peroxidasin 0.0048 0.002 0.006
Echinococcus multilocularis Smad4 0.0174 0.0167 0.0165
Leishmania major DNA polymerase eta, putative 0.016 0.0151 0.6835
Trypanosoma brucei DNA damage repair protein, putative 0.005 0.0021 0.0746
Brugia malayi hypothetical protein 0.0051 0.0023 0.0071
Onchocerca volvulus 0.0048 0.002 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0012
Brugia malayi Bromodomain containing protein 0.0122 0.0107 0.0353
Schistosoma mansoni opsin-like receptor 0.0048 0.002 0.0039
Onchocerca volvulus 0.0048 0.002 0.0166
Loa Loa (eye worm) animal heme peroxidase 0.0048 0.002 0.006
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.002 0.0039
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0002 0.0004
Loa Loa (eye worm) Smad1 0.0174 0.0167 0.0558
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0464 0.051 0.1011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0091 0.0069 0.0228
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0021 0.0892
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.002 0.006
Brugia malayi Animal haem peroxidase family protein 0.0048 0.002 0.006
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0087 0.855
Echinococcus granulosus tar DNA binding protein 0.0454 0.0497 0.0983
Brugia malayi beta-lactamase family protein 0.0036 0.0005 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.002 0.0036
Brugia malayi RE15519p 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0353 0.0378 0.127
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.002 0.0039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0049 0.317
Brugia malayi follicle stimulating hormone receptor 0.0289 0.0304 0.1018
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0067 0.0041 0.5355
Brugia malayi MH2 domain containing protein 0.0174 0.0167 0.0558
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) MH1 domain-containing protein 0.0078 0.0054 0.0176
Echinococcus granulosus allatostatin A receptor 0.0048 0.002 0.0036
Plasmodium vivax DNA repair protein REV1, putative 0.005 0.0021 0.2485
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.016 0.0151 0.0149
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0022 0.1319
Loa Loa (eye worm) hypothetical protein 0.0759 0.0857 0.2885
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0093 0.4095
Schistosoma mansoni peroxidasin 0.0048 0.002 0.0039
Echinococcus granulosus GTP binding nuclear protein Ran 0.0067 0.0041 0.0078
Toxoplasma gondii thioredoxin reductase 0.0046 0.0017 0.0018
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) TAR-binding protein 0.0454 0.0497 0.1671
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.002 0.006
Brugia malayi neuropeptide F receptor 0.0048 0.002 0.006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0464 0.051 0.1713
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0188 0.0185 0.0183
Echinococcus multilocularis importin subunit beta 1 0.0091 0.0069 0.0068
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0005 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0353 0.0378 0.0747
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0025 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0056 0.2493
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0012
Brugia malayi MH1 domain containing protein 0.0096 0.0076 0.025
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0151 0.6361
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0018 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Onchocerca volvulus 0.0048 0.002 0.0166
Trypanosoma brucei DNA damage repair protein, putative 0.005 0.0021 0.0746
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0069 0.3003
Brugia malayi Melatonin receptor type 1A 0.0048 0.002 0.006
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) RNA binding protein 0.0454 0.0497 0.1671
Onchocerca volvulus 0.0048 0.002 0.0166
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0235 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni hypothetical protein 0.0291 0.0306 0.0607
Echinococcus granulosus g protein coupled receptor 0.0048 0.002 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.0219 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.002 0.0018
Onchocerca volvulus 0.0047 0.0018 0.0146
Brugia malayi mbt repeat family protein 0.0047 0.0018 0.0056
Trypanosoma brucei unspecified product 0.011 0.0093 0.4095
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0017 0.0522
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.002 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.002 0.0036
Toxoplasma gondii ImpB/MucB/SamB family protein 0.005 0.0021 0.0024
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.016 0.0151 0.6361
Trypanosoma cruzi DNA polymerase kappa, putative 0.016 0.0151 0.6885
Schistosoma mansoni cellular tumor antigen P53 0.0149 0.0138 0.0273
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.002 0.0039
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.002 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0025 0.0049
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0022 0.0039
Echinococcus multilocularis neuropeptide receptor 0.0048 0.002 0.0018
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.002 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.002 0.0018
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus zinc finger protein 0.0064 0.0038 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0013 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.016 0.0151 0.6835
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0005 0.0228
Echinococcus multilocularis serotonin receptor 0.0759 0.0857 0.0855
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.002 0.0018
Echinococcus multilocularis g protein coupled receptor 0.0048 0.002 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0454 0.0497 0.0986
Echinococcus granulosus orexin receptor type 2 0.0048 0.002 0.0036
Leishmania major hypothetical protein, conserved 0.0217 0.0219 1
Brugia malayi PHD-finger family protein 0.0081 0.0058 0.0188
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.002 0.0166
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.002 0.0036
Echinococcus granulosus dna polymerase eta 0.016 0.0151 0.0296
Brugia malayi glutathione reductase 0.0046 0.0017 0.0052
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0033 0.0002 0.0004
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0053
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0087 0.3567
Schistosoma mansoni adenoreceptor 0.0048 0.002 0.0039
Trypanosoma brucei chrX additional, unordered contigs 0.005 0.0021 0.0746
Brugia malayi ImpB/MucB/SamB family protein 0.016 0.0151 0.0504
Echinococcus multilocularis tumor protein p63 0.1015 0.1158 0.1157
Onchocerca volvulus Peroxidasin homolog 0.0048 0.002 0.0166
Brugia malayi RNA, U transporter 1 0.0258 0.0266 0.0891
Brugia malayi ImpB/MucB/SamB family protein 0.016 0.0151 0.0504
Echinococcus multilocularis fmrfamide receptor 0.0048 0.002 0.0018
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.002 0.0036
Schistosoma mansoni neuropeptide receptor 0.0048 0.002 0.0039
Onchocerca volvulus 0.0048 0.002 0.0166
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Trypanosoma brucei unspecified product 0.011 0.0093 0.4095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0021 0.0746
Schistosoma mansoni importin beta-1 0.0091 0.0069 0.0138
Schistosoma mansoni neuropeptide receptor 0.0048 0.002 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0025 0.0049
Brugia malayi MH1 domain containing protein 0.0174 0.0167 0.0558
Leishmania major DNA damage repair protein, putative 0.005 0.0021 0.0746
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus importin subunit beta 1 0.0091 0.0069 0.0134
Onchocerca volvulus Dual oxidase homolog 0.0048 0.002 0.0166
Echinococcus multilocularis GPCR, family 2 0.0353 0.0378 0.0376
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Leishmania major trypanothione reductase 0.0046 0.0017 0.0561
Trypanosoma brucei DNA polymerase eta, putative 0.016 0.0151 0.6835
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0464 0.051 0.1713
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0018 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni hypothetical protein 0.0048 0.002 0.0039
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0069 0.3003
Brugia malayi G protein-coupled receptor 0.0048 0.002 0.006
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0047 0.0018 0.0053
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.002 0.0018
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.002 0.006
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0041 0.1814
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.002 0.0018
Echinococcus granulosus mothers against decapentaplegic 5 0.0174 0.0167 0.0328
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni hypothetical protein 0.4313 0.5042 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0056
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Echinococcus multilocularis sex peptide receptor 0.0048 0.002 0.0018
Onchocerca volvulus Peroxidase homolog 0.0048 0.002 0.0166
Schistosoma mansoni ran 0.0067 0.0041 0.0082
Schistosoma mansoni hypothetical protein 0.0048 0.002 0.0039
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.002 0.0039
Brugia malayi mbt repeat family protein 0.0047 0.0018 0.0056
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.002 0.006
Onchocerca volvulus 0.0036 0.0005 0.0032
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0047 0.0018 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0454 0.0497 0.0986
Loa Loa (eye worm) nuclear factor I 0.0096 0.0076 0.025
Loa Loa (eye worm) hypothetical protein 0.0078 0.0054 0.0176
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0047 0.0018 0.0146
Echinococcus multilocularis dna polymerase kappa 0.016 0.0151 0.0149
Brugia malayi RNA binding protein 0.0454 0.0497 0.1671
Trypanosoma cruzi DNA damage repair protein, putative 0.005 0.0021 0.0892
Echinococcus multilocularis fmrfamide receptor 0.0048 0.002 0.0018
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0018 0.0033
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.002 0.0018
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0187 0.0367
Onchocerca volvulus 0.0048 0.002 0.0166
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0353 0.0378 0.0376
Schistosoma mansoni transcription factor LCR-F1 0.0551 0.0612 0.1213
Brugia malayi beta-lactamase family protein 0.0036 0.0005 0.0012
Echinococcus multilocularis somatostatin receptor 0.0048 0.002 0.0018
Entamoeba histolytica hypothetical protein 0.0551 0.0612 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0047 0.0018 0.0016
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.007 0.0045 0.0089
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.002 0.0018
Toxoplasma gondii HEAT repeat-containing protein 0.0091 0.0069 0.0095
Schistosoma mansoni hypothetical protein 0.0048 0.002 0.0039
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.016 0.0151 0.03
Loa Loa (eye worm) hypothetical protein 0.0759 0.0857 0.2885
Loa Loa (eye worm) beta-lactamase 0.0036 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0012
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.002 0.0018
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.016 0.0151 0.0504
Brugia malayi Importin beta-1 subunit 0.0091 0.0069 0.0228
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0142 0.0282
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0017 0.0709
Schistosoma mansoni bromodomain containing protein 0.02 0.0198 0.0392
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0018 0.0036
Schistosoma mansoni amine GPCR 0.0048 0.002 0.0039
Loa Loa (eye worm) animal heme peroxidase 0.0048 0.002 0.006
Schistosoma mansoni tar DNA-binding protein 0.0454 0.0497 0.0986
Schistosoma mansoni biogenic amine receptor 0.0048 0.002 0.0039
Mycobacterium tuberculosis Probable reductase 0.0106 0.0087 0.3567
Loa Loa (eye worm) hypothetical protein 0.013 0.0115 0.0383
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Giardia lamblia DINP protein human, muc B family 0.016 0.0151 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Leishmania major DNA polymerase kappa, putative 0.005 0.0021 0.0746
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0551 0.0612 0.121
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.002 0.0036
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0026 0.0024
Brugia malayi hypothetical protein 0.0047 0.0018 0.0053
Schistosoma mansoni ran 0.0067 0.0041 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.0219 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0013 0.0022
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0056 0.0112
Loa Loa (eye worm) hypothetical protein 0.0762 0.0861 0.2897
Schistosoma mansoni hypothetical protein 0.0967 0.1102 0.2185
Loa Loa (eye worm) hypothetical protein 0.016 0.0151 0.0504
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0056 0.2493
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0087 0.3567
Schistosoma mansoni terminal deoxycytidyl transferase 0.016 0.0151 0.03
Loa Loa (eye worm) hypothetical protein 0.0053 0.0025 0.0078
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0018 0.0056
Schistosoma mansoni hypothetical protein 0.0551 0.0612 0.1213
Echinococcus multilocularis neuropeptide receptor 0.0048 0.002 0.0018
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.002 0.006
Brugia malayi N-terminal motif family protein 0.0948 0.1079 0.3634
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0067 0.0041 0.0133
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.016 0.0151 0.6835
Onchocerca volvulus Chorion peroxidase homolog 0.0048 0.002 0.0166
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus neuropeptide receptor 0.0048 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.4313 0.5042 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0005 0.0157
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0005 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Echinococcus granulosus somatostatin receptor 0.0048 0.002 0.0036
Schistosoma mansoni neuropeptide receptor 0.0048 0.002 0.0039
Mycobacterium ulcerans DNA polymerase IV 0.016 0.0151 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Echinococcus multilocularis peregrin 0.0041 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0012
Trichomonas vaginalis ran, putative 0.0067 0.0041 0.2635
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0021 0.0746
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.002 0.0036
Onchocerca volvulus 0.0048 0.002 0.0166
Entamoeba histolytica hypothetical protein 0.0073 0.0049 0.0777
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.002 0.0039
Entamoeba histolytica hypothetical protein 0.0551 0.0612 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0053 0.0025 0.0046
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0136 0.0122 0.0407
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0022 0.0024
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.002 0.0039
Brugia malayi Dopamine receptor protein 2 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0948 0.1079 0.3634
Echinococcus multilocularis zinc finger protein 0.0064 0.0038 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0093 0.4095
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0053 0.0025 0.0023
Schistosoma mansoni smad1 5 8 and 0.0174 0.0167 0.0332
Trypanosoma cruzi DNA damage repair protein, putative 0.005 0.0021 0.0892
Brugia malayi G-protein coupled receptor 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.0056 0.2373
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni smad1 5 8 and 0.0174 0.0167 0.0332
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0111 0.0094 0.0182
Trypanosoma cruzi importin beta-1 subunit, putative 0.0073 0.0049 0.2183
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0005 0.0228
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0067 0.0041 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.002 0.0018
Brugia malayi RNA recognition motif domain containing protein 0.0454 0.0497 0.1671
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0012
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.002 0.0018
Schistosoma mansoni opsin-like receptor 0.0048 0.002 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0005 0.0012
Brugia malayi Latrophilin receptor protein 2 0.0353 0.0378 0.127
Schistosoma mansoni hypothetical protein 0.0048 0.002 0.0039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.002 0.0018
Schistosoma mansoni zinc finger protein 0.0064 0.0038 0.0076
Leishmania major importin beta-1 subunit, putative 0.0073 0.0049 0.2058
Trypanosoma cruzi ISWI complex protein 0.0047 0.0019 0.0766
Echinococcus granulosus regulator of G protein signaling 7 0.0047 0.0018 0.0031
Trypanosoma cruzi ISWI complex protein 0.0047 0.0019 0.0766
Schistosoma mansoni zinc finger protein 0.0047 0.0019 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.002 0.0018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0289 0.0304 0.1018
Brugia malayi MH2 domain containing protein 0.255 0.2966 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0022 0.254
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.002 0.0036
Onchocerca volvulus 0.0048 0.002 0.0166
Echinococcus multilocularis serotonin receptor 0.0759 0.0857 0.0855
Schistosoma mansoni z-protein (S1r protein) 0.0047 0.0018 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Echinococcus multilocularis orexin receptor type 2 0.0048 0.002 0.0018
Echinococcus granulosus g protein coupled receptor 0.0048 0.002 0.0036
Onchocerca volvulus 0.0048 0.002 0.0166
Brugia malayi regulator of G-protein signaling egl-10 0.0047 0.0018 0.0053
Entamoeba histolytica deoxycytidyl transferase, putative 0.016 0.0151 0.245
Echinococcus granulosus mothers against decapentaplegic 6 0.0078 0.0054 0.0104
Loa Loa (eye worm) MH2 domain-containing protein 0.255 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni regulator of G protein signaling 0.0047 0.0018 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0021 0.0892
Mycobacterium ulcerans DNA polymerase IV 0.016 0.0151 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0047 0.0018 0.0016
Plasmodium falciparum thioredoxin reductase 0.0046 0.0017 0.1402
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0353 0.0378 0.127
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Echinococcus granulosus fetal alzheimer antigen falz 0.007 0.0045 0.0085
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0018 0.0016
Loa Loa (eye worm) blistered cuticle protein 3 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0119 0.0103 0.034
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0081 0.0156
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0005 0.0228
Echinococcus multilocularis mothers against decapentaplegic 2 0.0078 0.0054 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0093 0.4095
Brugia malayi GnHR receptor homolog 0.0048 0.002 0.006
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.002 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.255 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni dishevelled 0.0047 0.0018 0.0035
Leishmania major DNA polymerase eta, putative 0.005 0.0021 0.0746
Loa Loa (eye worm) animal heme peroxidase 0.0048 0.002 0.006
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0142 0.0473
Echinococcus granulosus sex peptide receptor 0.0048 0.002 0.0036
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0142 0.014
Schistosoma mansoni smad1 5 8 and 0.0174 0.0167 0.0332
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0078 0.0054 0.0486
Brugia malayi MH2 domain containing protein 0.0078 0.0054 0.0176
Brugia malayi Thioredoxin reductase 0.0046 0.0017 0.0052
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.002 0.0036
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0026 0.0048
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0005 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0048 0.002 0.0018
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0026 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Trypanosoma cruzi DNA polymerase eta, putative 0.016 0.0151 0.6885
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0005 0.0011
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0017 0.0031
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus multilocularis mothers against decapentaplegic 6 0.0078 0.0054 0.0052
Brugia malayi hypothetical protein 0.0551 0.0612 0.2056
Echinococcus granulosus tumor protein p63 0.1015 0.1158 0.2294
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.002 0.0039
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.002 0.0036
Brugia malayi putative neuropeptide receptor 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi Smad1 0.0174 0.0167 0.0558
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.002 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.002 0.0018
Schistosoma mansoni DNA polymerase eta 0.016 0.0151 0.03
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0025 0.0049
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.002 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0056 0.7781
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0082
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.0353 0.0378 0.075
Brugia malayi sulfakinin receptor protein 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.005 0.0021 0.0065
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0551 0.0612 0.061
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0037 0.0118
Brugia malayi jmjC domain containing protein 0.01 0.0081 0.0265
Brugia malayi beta-lactamase 0.0036 0.0005 0.0012
Echinococcus granulosus Smad4 0.0174 0.0167 0.0328
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0353 0.0378 0.0747
Echinococcus multilocularis segment polarity protein dishevelled 0.0047 0.0018 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0464 0.051 0.1011
Schistosoma mansoni Smad4 0.0174 0.0167 0.0332
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0013 0.0011
Schistosoma mansoni hypothetical protein 0.0353 0.0378 0.075
Echinococcus granulosus hypothetical protein 0.0048 0.002 0.0036
Echinococcus granulosus dna polymerase kappa 0.016 0.0151 0.0296
Echinococcus granulosus peregrin 0.0041 0.0012 0.0019
Schistosoma mansoni dishevelled 0.0047 0.0018 0.0035
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0948 0.1079 1
Onchocerca volvulus 0.0036 0.0005 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.002 0.0039
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.002 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.016 0.0151 0.6885
Trypanosoma brucei trypanothione reductase 0.0046 0.0017 0.0561
Echinococcus granulosus biogenic amine 5HT receptor 0.0759 0.0857 0.1697
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni amine GPCR 0.0048 0.002 0.0039
Schistosoma mansoni Smad4 0.0078 0.0054 0.0108
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.577 0.6757 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.002 0.0036
Echinococcus granulosus mothers against decapentaplegic 2 0.0078 0.0054 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0021 0.0746
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus geminin 0.4313 0.5042 1
Brugia malayi Animal haem peroxidase family protein 0.0048 0.002 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.002 0.0036
Loa Loa (eye worm) DIX domain-containing protein 0.0047 0.0018 0.0053
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0067 0.0041 0.1684
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0005 0.0157
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0017 0.0015
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.002 0.006
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0101 0.4173
Schistosoma mansoni histamine h1 receptor 0.0048 0.002 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.002 0.0018
Plasmodium vivax glutathione reductase, putative 0.0046 0.0017 0.1867
Trypanosoma brucei DNA polymerase IV, putative 0.016 0.0151 0.6835
Entamoeba histolytica Ran family GTPase 0.0067 0.0041 0.0646
Onchocerca volvulus 0.0048 0.002 0.0166
Schistosoma mansoni hypothetical protein 0.0064 0.0038 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Brugia malayi latrophilin 2 splice variant baaae 0.0762 0.0861 0.2897
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi hypothetical protein 0.0079 0.0056 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0026 0.0024
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0067 0.0041 0.0053
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0187 0.0185
Loa Loa (eye worm) hypothetical protein 0.1115 0.1276 0.4299
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0174 0.0167 0.0165
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.002 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0464 0.051 0.1008
Onchocerca volvulus 0.0047 0.0018 0.0153
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Onchocerca volvulus 0.0048 0.002 0.0166
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.002 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.002 0.0036
Onchocerca volvulus 0.0048 0.002 0.0166
Echinococcus granulosus GPCR family 2 0.0353 0.0378 0.0747
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.002 0.0036
Brugia malayi Bromodomain containing protein 0.0041 0.0012 0.0032
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0002 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0048 0.002 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.002 0.0018
Brugia malayi Serotonin receptor 0.0048 0.002 0.006
Trichomonas vaginalis DNA polymerase eta, putative 0.016 0.0151 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0087 0.3567
Brugia malayi AKH receptor 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.002 0.0018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.002 0.0039
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0026 0.0048
Plasmodium falciparum importin beta, putative 0.0091 0.0069 1
Onchocerca volvulus 0.0048 0.002 0.0166
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0101 0.4173
Trypanosoma brucei DNA polymerase IV, putative 0.016 0.0151 0.6835
Brugia malayi Dopamine receptor 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0149 0.0138 0.0458
Trichomonas vaginalis esterase, putative 0.0036 0.0005 0.0228
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.016 0.0151 1
Schistosoma mansoni biogenic amine receptor 0.0048 0.002 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.016 0.0151 0.6885
Loa Loa (eye worm) MH2 domain-containing protein 0.0078 0.0054 0.0176
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.002 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0005 0.0228
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.002 0.0039
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.002 0.006
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.002 0.0018
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.005 0.0021 0.0024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0464 0.051 0.0508
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0041 0.1814
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.002 0.0039
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0005 0.0003
Echinococcus granulosus segment polarity protein dishevelled 0.0047 0.0018 0.0031
Loa Loa (eye worm) MH1 domain-containing protein 0.0174 0.0167 0.0558
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0033 0.0002 0.0004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.002 0.0036
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0017 0.1867
Plasmodium vivax importin-beta 2, putative 0.0091 0.0069 1
Onchocerca volvulus 0.0048 0.002 0.0166
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0067 0.0041 0.5607
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.002 0.0018
Schistosoma mansoni myosin xvIII 0.0048 0.002 0.0039
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0038 0.0122
Brugia malayi jmjC domain containing protein 0.0043 0.0013 0.0038
Mycobacterium ulcerans hypothetical protein 0.005 0.0021 0.1092
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0012
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.002 0.006
Brugia malayi neuropeptide F receptor 0.0048 0.002 0.006
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Entamoeba histolytica hypothetical protein 0.0551 0.0612 1
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.002 0.006
Echinococcus granulosus Pleckstrin G protein interacting region 0.0047 0.0018 0.0031
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.002 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Echinococcus multilocularis segment polarity protein dishevelled 0.0047 0.0018 0.0016
Onchocerca volvulus 0.0048 0.002 0.0166
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi Serotonin receptor 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Onchocerca volvulus Peroxidasin homolog 0.0048 0.002 0.0166
Echinococcus granulosus segment polarity protein dishevelled 0.0047 0.0018 0.0031
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.002 0.0036
Loa Loa (eye worm) acetyltransferase 0.0152 0.0142 0.0473
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.002 0.0036
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0096 0.0076 0.025
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0018 0.0033
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0081 0.0079
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi Animal haem peroxidase family protein 0.0048 0.002 0.006
Echinococcus granulosus snurportin 1 0.0967 0.1102 0.2182
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0022 0.1319
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0005 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0049 0.317
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0101 1
Onchocerca volvulus 0.0036 0.0005 0.0032
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0005 0.0228
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.002 0.0036
Loa Loa (eye worm) bromodomain containing protein 0.0058 0.0031 0.0099
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.002 0.0036
Loa Loa (eye worm) animal heme peroxidase 0.0048 0.002 0.006
Brugia malayi Dopamine receptor protein 1 0.0048 0.002 0.006
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.002 0.0039
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0067 0.0041 0.2279
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus multilocularis allatostatin A receptor 0.0048 0.002 0.0018
Echinococcus granulosus peroxidasin 0.0048 0.002 0.0035
Toxoplasma gondii ImpB/MucB/SamB family protein 0.005 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus g protein coupled receptor 0.0048 0.002 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0021 0.0746
Echinococcus granulosus g-protein coupled receptor 0.0048 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni peroxidasin 0.0048 0.002 0.0039
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0006 0.0004
Schistosoma mansoni amine GPCR 0.0048 0.002 0.0039
Schistosoma mansoni biogenic amine receptor 0.0048 0.002 0.0039
Schistosoma mansoni DNA polymerase IV / kappa 0.005 0.0021 0.0042
Onchocerca volvulus 0.0048 0.002 0.0166
Onchocerca volvulus Peroxidase homolog 0.0048 0.002 0.0166
Schistosoma mansoni amine GPCR 0.0048 0.002 0.0039
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.002 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0047 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus multilocularis smad 0.0174 0.0167 0.0165
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.002 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0151 0.6835
Loa Loa (eye worm) glutathione reductase 0.0046 0.0017 0.0052
Echinococcus multilocularis dna polymerase eta 0.016 0.0151 0.0149
Brugia malayi Blistered cuticle protein 3 0.0048 0.002 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0464 0.051 0.1008
Schistosoma mansoni amine GPCR 0.0048 0.002 0.0039
Schistosoma mansoni neuropeptide receptor 0.0048 0.002 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0025 0.0046
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0174 0.0167 0.0165
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.002 0.0039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0087 0.3567
Echinococcus granulosus neuropeptide s receptor 0.0048 0.002 0.0036
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.002 0.0036
Onchocerca volvulus 0.0149 0.0138 0.1261
Onchocerca volvulus 0.0048 0.002 0.0166
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0013 0.0026
Brugia malayi MH2 domain containing protein 0.0174 0.0167 0.0558
Schistosoma mansoni opsin-like receptor 0.0048 0.002 0.0039
Schistosoma mansoni hypothetical protein 0.0036 0.0005 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.002 0.0039
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.002 0.006
Brugia malayi polk-prov protein 0.005 0.0021 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.016 0.0151 0.6885
Brugia malayi MH1 domain containing protein 0.0096 0.0076 0.025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0024 0.0076
Schistosoma mansoni Smad4 0.0078 0.0054 0.0108
Brugia malayi DIX domain containing protein 0.0047 0.0018 0.0053
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0047 0.0018 0.0053
Brugia malayi hypothetical protein 0.0048 0.002 0.006
Plasmodium falciparum glutathione reductase 0.0046 0.0017 0.1402
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0047 0.0018 0.0053
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006
Plasmodium falciparum DNA repair protein REV1, putative 0.005 0.0021 0.2056
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.002 0.0036
Schistosoma mansoni biogenic amine (5HT) receptor 0.0759 0.0857 0.17
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0464 0.051 0.1011
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0174 0.0167 0.0332
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0018 0.0036
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.002 0.0018
Echinococcus granulosus smad 0.0174 0.0167 0.0328
Echinococcus multilocularis geminin 0.4313 0.5042 0.5041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.006

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 75 nM Evaluated for inhibition of human cyclin dependent kinase 2 ChEMBL. 15115396
IC50 (binding) = 75 nM Inhibitory activity against human cyclin-dependent kinase 2 (CDK2) ChEMBL. 11728181
IC50 (binding) = 790 nM Inhibitory activity against human cyclin-dependent kinase 1 (CDK1) ChEMBL. 11728181

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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