Detailed information for compound 1399545

Basic information

Technical information
  • TDR Targets ID: 1399545
  • Name: STOCK1N-61832
  • MW: 528.599 | Formula: C30H32N4O5
  • H donors: 3 H acceptors: 5 LogP: 3.59 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@@H]1Cc2c(C3N1C(=O)c1c3cccc1)[nH]c1c2cccc1)C
  • InChi: 1S/C30H32N4O5/c1-16(2)14-22(29(37)33-13-7-12-23(33)30(38)39)32-27(35)24-15-20-17-8-5-6-11-21(17)31-25(20)26-18-9-3-4-10-19(18)28(36)34(24)26/h3-6,8-11,16,22-24,26,31H,7,12-15H2,1-2H3,(H,32,35)(H,38,39)/t22-,23+,24-,26?/m0/s1
  • InChiKey: CFUNPOBDQKNWHN-YGZCJARRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.002 0.0054 0.0077
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0272 0.1066
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0573 0.0649
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0573 0.0573
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0042 0.0104
Trypanosoma brucei heat shock protein, putative 0.0027 0.0125 0.0124
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0009 0.0013
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.019 0.1611 0.6662
Brugia malayi Doublecortin family protein 0.0042 0.0261 0.0259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.1352 0.135
Brugia malayi Trypsin-like protease protein 5 0.002 0.0054 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.2272 0.7866
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0342 0.0483
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Schistosoma mansoni neuropeptide receptor 0.0032 0.0171 0.0242
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0125 0.0729
Plasmodium falciparum DNA gyrase subunit B 0.0027 0.0125 0.0768
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0261 0.1611
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Schistosoma mansoni cpg binding protein 0.0031 0.0157 0.0222
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0009 0.001
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0027 0.0125 0.0124
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Brugia malayi RE15519p 0.0032 0.0171 0.0169
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0171 0.024
Trichomonas vaginalis esterase, putative 0.0043 0.0272 0.0936
Brugia malayi CXXC zinc finger family protein 0.0029 0.0142 0.014
Brugia malayi Dopamine receptor protein 2 0.0032 0.0171 0.0169
Echinococcus granulosus phosphoglycerate kinase 1 0.019 0.1611 0.2285
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0171 0.0192
Brugia malayi ecdysteroid receptor 0.0018 0.0037 0.0035
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0171 0.0242
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0171 0.024
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0125 0.0768
Loa Loa (eye worm) hypothetical protein 0.0043 0.0272 0.0272
Schistosoma mansoni opsin-like receptor 0.0032 0.0171 0.0242
Trypanosoma cruzi phosphoglycerate kinase, putative 0.007 0.0512 0.0511
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.0009 0.0013
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0015
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0261 0.0294
Schistosoma mansoni hypothetical protein 0.0018 0.0042 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0042 0.0104
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0171 0.0192
Brugia malayi hypothetical protein 0.0073 0.0537 0.0536
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0171 0.0242
Brugia malayi Phosphoglycerate kinase 0.019 0.1611 0.161
Brugia malayi G-protein coupled receptor 0.0032 0.0171 0.0169
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0037 0.004
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0272 0.0384
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0125 0.0124
Plasmodium vivax heat shock protein 86, putative 0.0027 0.0125 0.0768
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0042 0.0104
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0027 0.0125 0.0124
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0175 0.1075
Loa Loa (eye worm) hypothetical protein 0.0043 0.0272 0.0272
Echinococcus granulosus biogenic amine 5HT receptor 0.0518 0.4606 0.6537
Brugia malayi cytochrome P450 0.0018 0.0042 0.004
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0171 0.0192
Onchocerca volvulus Phospholipase A2 homolog 0.0104 0.0821 0.1811
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0125 0.0428
Leishmania major hypothetical protein, conserved 0.0027 0.0125 0.0124
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Onchocerca volvulus 0.0042 0.0261 0.0517
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0027 0.0125 0.0453
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0272 0.0272
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0009 0.001
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Brugia malayi Cytochrome P450 family protein 0.0058 0.0402 0.0401
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.2272 0.7866
Leishmania major cytochrome p450-like protein 0.0018 0.0042 0.004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.038 0.2232
Brugia malayi follicle stimulating hormone receptor 0.0266 0.2305 0.2304
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1447 0.1446
Schistosoma mansoni opsin-like receptor 0.0032 0.0171 0.0242
Schistosoma mansoni amine GPCR 0.0032 0.0171 0.0242
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0342 0.0483
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0272 0.1467
Echinococcus multilocularis geminin 0.0205 0.1742 0.1976
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0218 0.0841
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0125 0.0124
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0512 0.0511
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0171 0.0242
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0089
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0175 0.102
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0175 0.0333
Schistosoma mansoni rab6-interacting 0.0042 0.0261 0.037
Brugia malayi Cytochrome P450 family protein 0.0018 0.0042 0.004
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0037 0.005
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0009 0.0013
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0171 0.024
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0171 0.0192
Schistosoma mansoni opsin-like receptor 0.0032 0.0171 0.0242
Trypanosoma cruzi Heat shock protein 83, putative 0.0027 0.0125 0.0124
Toxoplasma gondii ABC1 family protein 0.0043 0.0272 0.1594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0037 0.0037
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0218 0.0625
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0009 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0042 0.0104
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.3671 0.4165
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0037 0.0052
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0125 0.0428
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0027 0.0125 0.0453
Onchocerca volvulus 0.0032 0.0171 0.0309
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0171 0.0171
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0037 0.005
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.002 0.0054 0.0053
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0037 0.0052
Loa Loa (eye worm) hypothetical protein 0.0043 0.0272 0.0272
Trichomonas vaginalis endoplasmin, putative 0.0027 0.0125 0.0428
Schistosoma mansoni rab6-interacting 0.0042 0.0261 0.037
Plasmodium falciparum endoplasmin, putative 0.0027 0.0125 0.0768
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0017 0.0094
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0171 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1448 0.501
Brugia malayi neuropeptide F receptor 0.0032 0.0171 0.0169
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0172 0.1447 0.8525
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0125 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.2272 0.7866
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Onchocerca volvulus Phospholipase A2 homolog 0.0493 0.437 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0037 0.0035
Echinococcus granulosus nmda type glutamate receptor 0.0052 0.0352 0.0497
Schistosoma mansoni cpg binding protein 0.0029 0.0142 0.0201
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0042 0.004
Mycobacterium ulcerans two component sensor kinase MprB 0.0027 0.0125 0.0294
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0027 0.0125 0.0294
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0342 0.0342
Treponema pallidum phosphoglycerate kinase 0.019 0.1611 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.044 0.0625
Onchocerca volvulus 0.0032 0.0171 0.0309
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0037 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0171 0.024
Loa Loa (eye worm) glutaminase 0.033 0.2888 0.2888
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0334 0.0474
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0175 0.1075
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0984 0.6103
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0027 0.0125 0.0294
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0171 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Onchocerca volvulus 0.0029 0.0142 0.0242
Mycobacterium tuberculosis Conserved protein 0.0027 0.0125 0.0453
Schistosoma mansoni lipoxygenase 0.0253 0.2183 0.3098
Echinococcus granulosus glutamate NMDA receptor subunit 0.0015 0.0009 0.001
Trypanosoma brucei heat shock protein, putative 0.0027 0.0125 0.0124
Schistosoma mansoni hypothetical protein 0.0032 0.0171 0.0242
Brugia malayi neuropeptide F receptor 0.0032 0.0171 0.0169
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0206 0.0576
Brugia malayi nuclear hormone receptor 0.0018 0.0037 0.0035
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0573 0.0572
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0171 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0037 0.0035
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0175 0.1075
Loa Loa (eye worm) beta-lactamase 0.0043 0.0272 0.0272
Brugia malayi GnHR receptor homolog 0.0032 0.0171 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0171 0.024
Toxoplasma gondii heat shock protein HSP90 0.0027 0.0125 0.0729
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0171 0.0192
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0051 0.0342 0.0486
Trypanosoma brucei heat shock protein, putative 0.0027 0.0125 0.0124
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0037 0.005
Loa Loa (eye worm) hypothetical protein 0.005 0.0334 0.0334
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0342 0.0387
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0171 0.024
Leishmania major cytochrome p450-like protein 0.0018 0.0042 0.004
Schistosoma mansoni microtubule-associated protein tau 0.0786 0.7044 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0054
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Brugia malayi nuclear receptor NHR-88 0.0018 0.0037 0.0035
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0342 0.0341
Brugia malayi Cytochrome P450 family protein 0.0036 0.0206 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0042 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0037 0.0035
Onchocerca volvulus 0.0043 0.0272 0.0542
Onchocerca volvulus 0.002 0.0054 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0051 0.0342 0.0486
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0171 0.0192
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0017 0.0024
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0125 0.0428
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1448 0.501
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0054
Echinococcus multilocularis serotonin receptor 0.0518 0.4606 0.5226
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0171 0.0192
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0027 0.0125 0.0428
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0037 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0342 0.0485
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.0009 0.0007
Trypanosoma brucei phosphoglycerate kinase 0.019 0.1611 0.161
Onchocerca volvulus 0.0032 0.0171 0.0309
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0175 0.0599
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0027 0.0125 0.0294
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0042 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0171 0.024
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0512 0.0511
Schistosoma mansoni endoplasmin 0.0027 0.0125 0.0178
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Loa Loa (eye worm) glutamate receptor 2 0.0015 0.0009 0.0009
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0042 0.0104
Schistosoma mansoni amine GPCR 0.0032 0.0171 0.0242
Echinococcus granulosus glycoprotein Antigen 5 0.002 0.0054 0.0075
Trypanosoma cruzi phosphoglycerate kinase, putative 0.019 0.1611 0.161
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0054
Brugia malayi heat shock protein 90 0.0027 0.0125 0.0124
Loa Loa (eye worm) glutamate receptor 1 0.0015 0.0009 0.0009
Onchocerca volvulus 0.002 0.0054 0.004
Onchocerca volvulus 0.0032 0.0171 0.0309
Trypanosoma brucei phosphoglycerate kinase, putative 0.007 0.0512 0.0511
Loa Loa (eye worm) heat shock protein 90 0.0027 0.0125 0.0125
Echinococcus granulosus GPCR family 2 0.0051 0.0342 0.0484
Echinococcus multilocularis enteropeptidase 0.002 0.0054 0.006
Brugia malayi Phospholipase A2 family protein 0.0104 0.0821 0.082
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0171 0.024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0171 0.0242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0125 0.0428
Brugia malayi Trypsin family protein 0.002 0.0054 0.0053
Onchocerca volvulus 0.0043 0.0272 0.0542
Trichomonas vaginalis glutaminase, putative 0.033 0.2888 1
Schistosoma mansoni polycystin 1-related 0.0042 0.0261 0.037
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0272 0.0809
Schistosoma mansoni histamine h1 receptor 0.0032 0.0171 0.0242
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0017 0.0017
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0567 0.505 0.505
Trypanosoma brucei heat shock protein, putative 0.0027 0.0125 0.0124
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0171 0.024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0037 0.0035
Echinococcus granulosus g protein coupled receptor 0.0032 0.0171 0.024
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0261 0.0368
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0171 0.0192
Loa Loa (eye worm) hypothetical protein 0.0051 0.0342 0.0342
Brugia malayi phosphofructokinase 0.0121 0.0984 0.0982
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1505 0.3388
Echinococcus multilocularis 0.0018 0.0042 0.0045
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0272 0.027
Brugia malayi Dopamine receptor 0.0032 0.0171 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0175 0.0599
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0171 0.0192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0037 0.004
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.002 0.0054 0.0077
Onchocerca volvulus 0.0032 0.0171 0.0309
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0037 0.0037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0054 0.0077
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0077 0.011
Echinococcus multilocularis glycoprotein Antigen 5 0.002 0.0054 0.006
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1447 0.1446
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0125 0.0124
Onchocerca volvulus 0.0032 0.0171 0.0309
Mycobacterium tuberculosis Conserved protein 0.0043 0.0272 0.1066
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0171 0.0309
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Echinococcus granulosus heat shock protein 0.0027 0.0125 0.0175
Loa Loa (eye worm) hypothetical protein 0.0043 0.0272 0.0272
Echinococcus granulosus allatostatin A receptor 0.0032 0.0171 0.024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0342 0.0387
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0171 0.0171
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0272 0.1066
Loa Loa (eye worm) cytochrome P450 0.0018 0.0042 0.0042
Loa Loa (eye worm) trypsin family protein 0.002 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0518 0.4606 0.4606
Toxoplasma gondii DNA topoisomerase 2, putative 0.0027 0.0125 0.0729
Brugia malayi Probable DNA topoisomerase II 0.0027 0.0125 0.0124
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Trypanosoma brucei heat shock protein, putative 0.0027 0.0125 0.0124
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Onchocerca volvulus 0.0032 0.0171 0.0309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0171 0.0192
Brugia malayi sulfakinin receptor protein 0.0032 0.0171 0.0169
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0009 0.0008
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0171 0.0242
Trypanosoma brucei Heat shock protein 83, putative 0.0027 0.0125 0.0124
Onchocerca volvulus 0.002 0.0054 0.004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0171 0.0242
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0027 0.0125 0.0453
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0272 0.1066
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0171 0.0242
Schistosoma mansoni hypothetical protein 0.0205 0.1742 0.2474
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0027 0.0125 0.0294
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0171 0.024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0171 0.0169
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0342 0.0484
Schistosoma mansoni biogenic amine receptor 0.0032 0.0171 0.0242
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0272 0.0936
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1448 0.501
Plasmodium falciparum heat shock protein 90 0.0027 0.0125 0.0768
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0573 0.0573
Mycobacterium leprae Probable two component sensor kinase MprB 0.0027 0.0125 0.0532
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0017 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0272 0.027
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.019 0.1611 1
Echinococcus granulosus g protein coupled receptor 0.0032 0.0171 0.024
Echinococcus granulosus transmembrane protease serine 3 0.002 0.0054 0.0075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0272 0.0386
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0171 0.0192
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.02 0.1697 1
Echinococcus granulosus microtubule associated protein 2 0.0786 0.7044 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0493 0.4371 0.496
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0042 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0272 0.027
Brugia malayi putative neuropeptide receptor 0.0032 0.0171 0.0169
Echinococcus multilocularis Mastin 0.002 0.0054 0.006
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0171 0.0192
Trichomonas vaginalis sensor histidine kinase, putative 0.0027 0.0125 0.0428
Schistosoma mansoni cpg binding protein 0.0031 0.0157 0.0222
Onchocerca volvulus 0.005 0.0334 0.0686
Echinococcus granulosus serotonin receptor 0.0032 0.0171 0.024
Trypanosoma cruzi phosphoglycerate kinase, putative 0.019 0.1611 0.161
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0171 0.0171
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0984 0.0982
Schistosoma mansoni glutaminase 0.033 0.2888 0.4099
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0017 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0037 0.004
Onchocerca volvulus 0.0032 0.0171 0.0309
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0175 0.1075
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0042 0.0104
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0054 0.0077
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0037 0.005
Brugia malayi hypothetical protein 0.0042 0.0261 0.0259
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0077 0.0108
Brugia malayi 6-phosphofructokinase 0.0121 0.0984 0.0982
Brugia malayi Serotonin receptor 0.0032 0.0171 0.0169
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0042 0.0104
Loa Loa (eye worm) hypothetical protein 0.0104 0.0821 0.0821
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0027 0.0125 0.0532
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0984 0.3403
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0171 0.0192
Schistosoma mansoni pyruvate dehydrogenase 0.0465 0.4121 0.585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0037 0.0037
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0009 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0042 0.0104
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0015
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0206 0.0204
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0054 0.0077
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0125 0.0124
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0125 0.0768
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0171 0.024
Mycobacterium ulcerans hypothetical protein 0.002 0.0054 0.0044
Onchocerca volvulus 0.0042 0.0261 0.0517
Schistosoma mansoni endoplasmin 0.0027 0.0125 0.0178
Schistosoma mansoni hypothetical protein 0.002 0.0054 0.0077
Schistosoma mansoni pyruvate dehydrogenase 0.0465 0.4121 0.585
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0054
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0171 0.0192
Trypanosoma brucei phosphoglycerate kinase 0.019 0.1611 0.161
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0125 0.0124
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0175 0.0333
Echinococcus granulosus geminin 0.0205 0.1742 0.2472
Trypanosoma brucei heat shock protein, putative 0.0027 0.0125 0.0124
Schistosoma mansoni hypothetical protein 0.0032 0.0171 0.0242
Brugia malayi N-terminal motif family protein 0.0179 0.1505 0.1504
Mycobacterium ulcerans two component regulator - sensor kinase 0.0027 0.0125 0.0294
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0027 0.0125 0.0428
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0171 0.024
Mycobacterium tuberculosis Possible two component sensor kinase 0.0027 0.0125 0.0453
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0027 0.0125 0.0453
Echinococcus multilocularis GPCR, family 2 0.0051 0.0342 0.0387
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0027 0.0125 0.0768
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0027 0.0125 0.0453
Brugia malayi RNA binding protein 0.0076 0.0573 0.0572
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0171 0.0169
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0037 0.0052
Leishmania major phosphoglycerate kinase C, glycosomal 0.019 0.1611 0.161
Brugia malayi hypothetical protein 0.0042 0.0261 0.0259
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0171 0.0171
Echinococcus granulosus enteropeptidase 0.002 0.0054 0.0075
Schistosoma mansoni hypothetical protein 0.0205 0.1742 0.2474
Loa Loa (eye worm) hypothetical protein 0.0179 0.1505 0.1505
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0037 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.2272 0.7866
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0171 0.024
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0171 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0037 0.0035
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0042 0.0236
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0272 0.1679
Trypanosoma brucei heat shock protein, putative 0.0027 0.0125 0.0124
Toxoplasma gondii heat shock protein 90, putative 0.0027 0.0125 0.0729
Loa Loa (eye worm) TOPoisomerase family member 0.0027 0.0125 0.0125
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0017
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0125 0.0768
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0171 0.024
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0984 0.6103
Onchocerca volvulus 0.0032 0.0171 0.0309
Leishmania major cytochrome p450-like protein 0.0036 0.0206 0.0204
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0037 0.005
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.0077 0.0086
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0037 0.0052
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1447 0.1446
Chlamydia trachomatis glutamine binding protein 0.0038 0.0218 0.0625
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.2272 0.2271
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0171 0.0192
Echinococcus multilocularis heat shock protein 90 0.0027 0.0125 0.014
Loa Loa (eye worm) hypothetical protein 0.0043 0.0272 0.0272
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0984 0.1397
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0054 0.0077
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0984 0.6003
Schistosoma mansoni DNA topoisomerase II 0.0027 0.0125 0.0178
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Echinococcus granulosus tar DNA binding protein 0.0076 0.0573 0.0812
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0015
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0218 0.0625
Echinococcus granulosus g protein coupled receptor 0.0032 0.0171 0.024
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0175 0.1075
Brugia malayi TAR-binding protein 0.0076 0.0573 0.0572
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0017 0.0015
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.007 0.0512 0.0511
Echinococcus granulosus fmrfamide receptor 0.0032 0.0171 0.024
Echinococcus granulosus Mastin 0.002 0.0054 0.0075
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0272 0.0809
Plasmodium falciparum DNA topoisomerase 2 0.0027 0.0125 0.0768
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Schistosoma mansoni biogenic amine receptor 0.0032 0.0171 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0037 0.0035
Schistosoma mansoni heat shock protein 0.0027 0.0125 0.0178
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.0073 0.0537 0.0763
Trichomonas vaginalis DNA topoisomerase II, putative 0.0027 0.0125 0.0428
Echinococcus multilocularis RUN 0.0042 0.0261 0.0294
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0171 0.0171
Trypanosoma brucei heat shock protein, putative 0.0027 0.0125 0.0124
Schistosoma mansoni biogenic amine (5HT) receptor 0.0518 0.4606 0.6538
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Brugia malayi Phosphoglycerate kinase 0.007 0.0512 0.0511
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0125 0.0428
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0261 0.0294
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.019 0.1611 0.1611
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0037 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0573 0.0814
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0142 0.0142
Echinococcus multilocularis serotonin receptor 0.0518 0.4606 0.5226
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0077 0.0108
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1448 0.501
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0054 0.0077
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0984 0.4041
Schistosoma mansoni neuropeptide receptor 0.0032 0.0171 0.0242
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.8812 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0272 0.0936
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0984 0.0982
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0261 0.0294
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0984 0.0982
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0171 0.0192
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0984 0.1397
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0042 0.0104
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0037 0.0037
Echinococcus granulosus cpg binding protein 0.0031 0.0157 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0175 0.0599
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0984 0.3403
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0342 0.0386
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus multilocularis cpg binding protein 0.0031 0.0157 0.0176
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0984 0.5778
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0125 0.0124
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Loa Loa (eye worm) hypothetical protein 0.0493 0.437 0.437
Mycobacterium ulcerans glutaminase 0.033 0.2888 1
Mycobacterium ulcerans DNA gyrase subunit B 0.0027 0.0125 0.0294
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0042 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.2272 0.7866
Trypanosoma brucei phosphoglycerate kinase 0.007 0.0512 0.0511
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0125 0.0204
Chlamydia trachomatis phosphoglycerate kinase 0.019 0.1611 1
Echinococcus multilocularis transmembrane protease serine 3 0.002 0.0054 0.006
Onchocerca volvulus 0.0032 0.0171 0.0309
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0125
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0171 0.0192
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0171 0.024
Onchocerca volvulus 0.002 0.0054 0.004
Loa Loa (eye worm) hypothetical protein 0.0493 0.4371 0.4371
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0017
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0037 0.004
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0042 0.0104
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0272 0.0386
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0171 0.0242
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0171 0.024
Schistosoma mansoni amine GPCR 0.0032 0.0171 0.0242
Leishmania major DNA topoisomerase ii 0.0027 0.0125 0.0124
Onchocerca volvulus 0.0032 0.0171 0.0309
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.2305 0.2305
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0042 0.004
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0984 0.6103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0175 0.102
Entamoeba histolytica phosphoglycerate kinase, putative 0.019 0.1611 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0027 0.0125 0.0124
Echinococcus multilocularis microtubule associated protein 2 0.0786 0.7044 0.7994
Onchocerca volvulus 0.0032 0.0171 0.0309
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0984 0.1395
Schistosoma mansoni hypothetical protein 0.0032 0.0171 0.0242
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.0077 0.0108
Echinococcus multilocularis sex peptide receptor 0.0032 0.0171 0.0192
Loa Loa (eye worm) hypothetical protein 0.0518 0.4606 0.4606
Schistosoma mansoni hypothetical protein 0.0051 0.0342 0.0486
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0037 0.0035
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0171 0.0242
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0027 0.0125 0.0453
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0037 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Brugia malayi beta-lactamase family protein 0.0043 0.0272 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0171 0.0242
Loa Loa (eye worm) hypothetical protein 0.0162 0.1352 0.1352
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Toxoplasma gondii phosphoglycerate kinase PGKI 0.019 0.1611 0.9493
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0171 0.0192
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0171 0.0192
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0171 0.0242
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0206 0.0204
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0171 0.0192
Onchocerca volvulus 0.0032 0.0171 0.0309
Echinococcus granulosus glutamate receptor 2 0.0022 0.0077 0.0108
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0171 0.0171
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0042 0.0104
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0253 0.2183 0.3097
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0027 0.0125 0.0124
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0984 0.0984
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0175 0.1075
Schistosoma mansoni hypothetical protein 0.0051 0.0342 0.0486
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0042 0.0104
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0027 0.0125 0.0428
Brugia malayi ORL1-like opioid receptor 0.0032 0.0171 0.0169
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0125 0.0204
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0984 0.3311
Giardia lamblia Phosphoglycerate kinase 0.019 0.1611 1
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0171 0.024
Onchocerca volvulus 0.002 0.0054 0.004
Echinococcus multilocularis nmda type glutamate receptor 0.0052 0.0352 0.0398
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0171 0.024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0261
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0037 0.0052
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0261 0.0261
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0171 0.024
Entamoeba histolytica hypothetical protein 0.0073 0.0537 0.3329
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0037 0.0052
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0037 0.004
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0077 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.2272 0.7866
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0171 0.0192
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0171 0.024
Loa Loa (eye worm) endoplasmin 0.0027 0.0125 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0111 0.0884 0.0884
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0342 0.0485
Loa Loa (eye worm) glutaminase 2 0.033 0.2888 0.2888
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0077 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0171 0.0192
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0272 0.0936
Brugia malayi hypothetical protein 0.002 0.0054 0.0053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0342 0.0342
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0984 0.3403
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0171 0.0192
Schistosoma mansoni hypothetical protein 0.0015 0.0009 0.0013
Echinococcus granulosus RUN 0.0042 0.0261 0.0368
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0272 0.0936
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.002 0.0054 0.006
Mycobacterium ulcerans lipase LipD 0.0043 0.0272 0.0809
Brugia malayi Melatonin receptor type 1A 0.0032 0.0171 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0175 0.0599
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0077 0.0086
Brugia malayi G-protein coupled receptor 0.0032 0.0171 0.0169
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0027 0.0125 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0037 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0171 0.024
Echinococcus granulosus heat shock protein 90 0.0027 0.0125 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0342 0.034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0171 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0037 0.005
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0009 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0402 0.0402
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0171 0.0171
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0493 0.4371 0.496
Brugia malayi kinase, mitochondrial precursor 0.0493 0.4371 0.437
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0037 0.004
Trypanosoma cruzi phosphoglycerate kinase, putative 0.007 0.0512 0.0511
Mycobacterium ulcerans hypothetical protein 0.0043 0.0272 0.0809
Plasmodium vivax phosphoglycerate kinase, putative 0.019 0.1611 1
Schistosoma mansoni phosphoglycerate kinase 0.019 0.1611 0.2287
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.002 0.0054 0.0075
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0125 0.0768
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0009 0.0013
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0125 0.0124
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0015 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Schistosoma mansoni adenoreceptor 0.0032 0.0171 0.0242
Brugia malayi steroid hormone receptor 0.0018 0.0037 0.0035
Leishmania major developmentally regulated phosphoprotein-like protein 0.0493 0.4371 0.437
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0171 0.0242
Entamoeba histolytica DNA topoisomerase II, putative 0.0027 0.0125 0.0768
Trypanosoma brucei DNA topoisomerase ii 0.0027 0.0125 0.0124
Onchocerca volvulus 0.0032 0.0171 0.0309
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0537 0.0763
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0032 0.0171 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0342 0.0386
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Echinococcus granulosus somatostatin receptor 0.0032 0.0171 0.024
Mycobacterium ulcerans beta-lactamase 0.0043 0.0272 0.0809
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0037 0.005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0342 0.0484
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0493 0.4371 0.6205
Brugia malayi isocitrate dehydrogenase 0.0016 0.0017 0.0015
Echinococcus granulosus dnaJ subfamily B 0.0416 0.3671 0.521
Echinococcus granulosus orexin receptor type 2 0.0032 0.0171 0.024
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0125 0.0124
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0037 0.004
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.2272 0.2272
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0171 0.0192
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0512 0.0511
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0984 0.1115
Entamoeba histolytica hypothetical protein 0.0073 0.0537 0.3329
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0206 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0573 0.0814
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0261
Echinococcus granulosus neuropeptide receptor 0.0032 0.0171 0.024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0171 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1448 0.501
Schistosoma mansoni lipoxygenase 0.0177 0.1488 0.2113
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0537 0.0761
Schistosoma mansoni pyruvate dehydrogenase 0.0493 0.4371 0.6205
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0175 0.102
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0218 0.0625
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0175 0.0599
Schistosoma mansoni cytochrome P450 0.0018 0.0042 0.0059
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0125 0.0124
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0017 0.0017
Mycobacterium ulcerans putative regultory protein 0.0027 0.0125 0.0294
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0342 0.0341
Entamoeba histolytica hypothetical protein 0.0073 0.0537 0.3329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0037 0.0037
Brugia malayi 6-phosphofructokinase 0.0121 0.0984 0.0982
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0206 0.0204
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0261 0.1611
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0171 0.0192
Echinococcus multilocularis somatostatin receptor 0.0032 0.0171 0.0192
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0171 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0171 0.0192
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0171 0.0169
Brugia malayi beta-lactamase 0.0043 0.0272 0.027
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0037 0.0052
Schistosoma mansoni heat shock protein 0.0027 0.0125 0.0178
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0037 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0171 0.0242
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0272 0.0307
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0021
Plasmodium vivax DNA topoisomerase II, putative 0.0027 0.0125 0.0768
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0032 0.0171 0.0309
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0027 0.0125 0.0294
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0054
Schistosoma mansoni biogenic amine receptor 0.0032 0.0171 0.0242
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.241 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0171 0.0169
Brugia malayi Trypsin family protein 0.002 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1448 0.501
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0272 0.027
Schistosoma mansoni myosin xvIII 0.0032 0.0171 0.0242
Echinococcus granulosus tumor protein p63 0.0344 0.3011 0.4273
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0125 0.0204
Brugia malayi beta-lactamase family protein 0.0043 0.0272 0.027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0537 0.0608
Brugia malayi Serotonin receptor 0.0032 0.0171 0.0169
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0009 0.0008
Onchocerca volvulus 0.002 0.0054 0.004
Loa Loa (eye worm) RNA binding protein 0.0076 0.0573 0.0573
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0573 0.0814
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0037 0.004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0052 0.0352 0.0398
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1532 0.5304
Leishmania major phosphoglycerate kinase B, cytosolic 0.019 0.1611 0.161
Brugia malayi G protein-coupled receptor 0.0032 0.0171 0.0169
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0042 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0037 0.0035
Schistosoma mansoni coup transcription factor 0.0018 0.0037 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0037 0.0037
Trypanosoma brucei developmentally regulated phosphoprotein 0.0493 0.4371 0.437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0171 0.0192
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0171 0.0242
Brugia malayi AKH receptor 0.0032 0.0171 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0027 0.0125 0.0453
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0171 0.0192
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0027 0.0125 0.0175
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0027 0.0125 0.0453
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0037 0.005
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0009 0.001
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0125 0.0124
Schistosoma mansoni amine GPCR 0.0032 0.0171 0.0242
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0218 0.062
Plasmodium vivax endoplasmin, putative 0.0027 0.0125 0.0768
Loa Loa (eye worm) hypothetical protein 0.0043 0.0272 0.0272
Schistosoma mansoni neuropeptide receptor 0.0032 0.0171 0.0242
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0077 0.0086
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0171 0.0169
Schistosoma mansoni phosphoglycerate kinase 0.019 0.1611 0.2287
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0171 0.024
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Schistosoma mansoni loxhd1 0.0042 0.0261 0.037
Schistosoma mansoni hypothetical protein 0.0416 0.3671 0.5211
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0009 0.0013
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0027 0.0125 0.0294
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0171 0.024
Brugia malayi Endoplasmin precursor 0.0027 0.0125 0.0124
Trichomonas vaginalis phosphoglycerate kinase, putative 0.019 0.1611 0.5577
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0171 0.0192
Onchocerca volvulus 0.0043 0.0272 0.0542
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0125 0.0124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0253 0.2183 0.2476
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0027 0.0125 0.0453
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0272 0.1066
Mycobacterium ulcerans phosphoglycerate kinase 0.019 0.1611 0.5515
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus multilocularis NMDA receptor 0.0015 0.0009 0.0008
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0171 0.0242
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0054 0.0077
Schistosoma mansoni hypothetical protein 0.0042 0.0261 0.037
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0261 0.0368
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0171 0.0171
Brugia malayi Dopamine receptor protein 1 0.0032 0.0171 0.0169
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0042 0.0104
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0171 0.0242
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0037 0.0052
Brugia malayi hypothetical protein 0.0032 0.0171 0.0169
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0171 0.024
Echinococcus granulosus hypothetical protein 0.0032 0.0171 0.024
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0042 0.0057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0175 0.0333
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0027 0.0125 0.0453
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0272 0.1066
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0493 0.4371 0.437
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0171 0.024
Leishmania major hypothetical protein, conserved 0.0043 0.0272 0.027
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0125 0.0124
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0027 0.0125 0.0532
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0017 0.0094
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0125 0.0124
Echinococcus granulosus neuropeptide receptor 0.0032 0.0171 0.024
Echinococcus multilocularis phosphoglycerate kinase 1 0.019 0.1611 0.1827
Schistosoma mansoni neuropeptide receptor 0.0032 0.0171 0.0242
Giardia lamblia Pms1-like protein 0.0027 0.0125 0.0768
Echinococcus multilocularis heat shock protein 0.0027 0.0125 0.014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.1352 0.1352
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.002 0.0054 0.0075
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0171 0.0309
Entamoeba histolytica hypothetical protein 0.0073 0.0537 0.3329
Schistosoma mansoni hypothetical protein 0.0111 0.0884 0.1255
Brugia malayi larval opioid receptor 0.0032 0.0171 0.0169
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0017
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0171 0.024
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0077 0.0086
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0171 0.0192
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Brugia malayi Trypsin family protein 0.002 0.0054 0.0053
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0171 0.0169
Mycobacterium leprae Probable two-component sensor kinase 0.0027 0.0125 0.0532
Onchocerca volvulus 0.0032 0.0171 0.0309
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0171 0.024
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0261 0.0368
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0037 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0171 0.0192
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0125 0.0729
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1532 0.5304
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0171 0.0171
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0042 0.0104
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0027 0.0125 0.0294
Leishmania major mitochondrial DNA topoisomerase II 0.0027 0.0125 0.0124
Mycobacterium tuberculosis Conserved protein 0.0043 0.0272 0.1066
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0171 0.0169
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.1352 0.135
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0171 0.0192
Echinococcus granulosus sex peptide receptor 0.0032 0.0171 0.024
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0884 0.0883
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0027 0.0125 0.014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0171 0.0242
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.002 0.0054 0.006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0573 0.0814
Brugia malayi glutaminase DH11.1 0.033 0.2888 0.2886
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0984 0.3403
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0171 0.024
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0171 0.0242
Schistosoma mansoni amine GPCR 0.0032 0.0171 0.0242
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0037 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0037 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0171 0.024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1448 0.501
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0042 0.0104
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0042 0.0104
Mycobacterium leprae Probable lipase LipE 0.0043 0.0272 0.1467
Toxoplasma gondii phosphoglycerate kinase PGKII 0.019 0.1611 0.9493
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0984 0.0984
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.1448 0.3255
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Plasmodium falciparum phosphoglycerate kinase 0.019 0.1611 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0054 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0342 0.0485
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0171 0.024
Mycobacterium tuberculosis Conserved protein 0.0043 0.0272 0.1066
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0171 0.0242
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0171 0.0242
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0027 0.0125 0.0453
Echinococcus multilocularis tumor protein p63 0.0344 0.3011 0.3416
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0984 0.0984
Brugia malayi Trypsin family protein 0.002 0.0054 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0206 0.0206
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0171 0.0192
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0171 0.0192
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0272 0.1066
Plasmodium vivax DNA gyrase subunit B, putative 0.0027 0.0125 0.0768
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0206 0.0206
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0272 0.1066
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0042 0.004
Mycobacterium tuberculosis Probable two component sensor kinase 0.0027 0.0125 0.0453
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0171 0.0192
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0037 0.0052
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0175 0.0599
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0175 0.0599
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0054 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Onchocerca volvulus 0.0032 0.0171 0.0309
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0171 0.0192
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0171 0.024
Brugia malayi Cytochrome P450 family protein 0.0036 0.0206 0.0204
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0272 0.0936
Trichomonas vaginalis phosphoglycerate kinase, putative 0.019 0.1611 0.5577
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0171 0.0192
Leishmania major heat shock protein 83-1 0.0027 0.0125 0.0124
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.019 0.1611 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0037 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0573 0.0814
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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