Detailed information for compound 1403419

Basic information

Technical information
  • TDR Targets ID: 1403419
  • Name: 1-[1-methyl-2-[2-(4-methylpiperidin-1-yl)ethy l]benzimidazol-5-yl]-3-phenylurea
  • MW: 391.509 | Formula: C23H29N5O
  • H donors: 2 H acceptors: 2 LogP: 3.62 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)CCc1nc2c(n1C)ccc(c2)NC(=O)Nc1ccccc1
  • InChi: 1S/C23H29N5O/c1-17-10-13-28(14-11-17)15-12-22-26-20-16-19(8-9-21(20)27(22)2)25-23(29)24-18-6-4-3-5-7-18/h3-9,16-17H,10-15H2,1-2H3,(H2,24,25,29)
  • InChiKey: SLKSMRTUBKICIW-UHFFFAOYSA-N  


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Synonyms

  • 1-[1-methyl-2-[2-(4-methyl-1-piperidyl)ethyl]benzimidazol-5-yl]-3-phenyl-urea
  • 1-[1-methyl-2-[2-(4-methyl-1-piperidinyl)ethyl]-5-benzimidazolyl]-3-phenylurea
  • 1-[1-methyl-2-[2-(4-methylpiperidin-1-yl)ethyl]benzimidazol-5-yl]-3-phenyl-urea
  • MLS000083583
  • SMR000048388

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0041 0.0276 0.2099
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0328 0.0419
Leishmania major histone-lysine N-methyltransferase, putative 0.0085 0.0729 0.6245
Brugia malayi Pre-SET motif family protein 0.0251 0.2456 0.3629
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0098 0.0076
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.0328 0.0419
Schistosoma mansoni polycystin 1-related 0.0024 0.0098 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0328 0.0419
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0085 0.0729 0.6245
Plasmodium vivax glutathione reductase, putative 0.0057 0.0437 1
Echinococcus multilocularis serotonin receptor 0.0046 0.0328 0.0283
Loa Loa (eye worm) hypothetical protein 0.0119 0.1083 0.1543
Mycobacterium ulcerans hypothetical protein 0.0035 0.0215 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0454 0.041
Schistosoma mansoni patched 1 0.0051 0.038 0.0496
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.0328 0.0419
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0116 0.0635
Brugia malayi putative neuropeptide receptor 0.0046 0.0328 0.0485
Brugia malayi Protein arginine N-methyltransferase 0.0124 0.1139 0.1683
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0215 0.0584
Echinococcus granulosus snurportin 1 0.0372 0.3703 0.5442
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0215 0.0759
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0098 0.0076
Toxoplasma gondii thioredoxin reductase 0.0057 0.0437 0.5723
Onchocerca volvulus 0.0286 0.2815 1
Onchocerca volvulus 0.006 0.047 0.137
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1083 0.1041
Brugia malayi Doublecortin family protein 0.0024 0.0098 0.0144
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0116 0.1777
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0224 0.0265
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0587 0.0804
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0587 0.0804
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0587 0.0804
Loa Loa (eye worm) hypothetical protein 0.006 0.047 0.063
Echinococcus granulosus neuropeptide receptor 0.0046 0.0328 0.0419
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0054 0.0063
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0054 0.0177
Brugia malayi G-protein coupled receptor 0.0046 0.0328 0.0485
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.0328 0.0419
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0328 0.0419
Mycobacterium tuberculosis Conserved protein 0.0035 0.0215 0.0759
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2456 0.3585
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.0328 0.0485
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0054 0.0011
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0085 0.0729 0.6245
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.038 0.0496
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0215 0.0584
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0215 0.0584
Loa Loa (eye worm) beta-lactamase 0.0035 0.0215 0.0251
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0437 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.0328 0.0419
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0063
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0054 0.0177
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0328 0.0283
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.0328 0.0419
Leishmania major hypothetical protein, conserved 0.0085 0.0729 0.6245
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0047 0.0001
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0098 0.0051
Schistosoma mansoni hypothetical protein 0.0024 0.0098 0.0076
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0328 0.0419
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0328 0.0283
Mycobacterium tuberculosis Probable oxidoreductase 0.0143 0.1338 0.6037
Brugia malayi hypothetical protein 0.0024 0.0098 0.0144
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Trypanosoma brucei histone-lysine n-methyltransferase 0.0085 0.0729 0.6245
Plasmodium falciparum thioredoxin reductase 0.002 0.0054 0.0177
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0072 0.0652
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0314 0.0269
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0072 0.0087
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3703 0.5442
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0116 0.0172
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.0328 0.0419
Brugia malayi CHE-14 protein 0.0051 0.038 0.0561
Brugia malayi neuropeptide F receptor 0.0046 0.0328 0.0485
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.0328 0.0419
Echinococcus granulosus g-protein coupled receptor 0.0046 0.0328 0.0419
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0328 0.0419
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.0328 0.0419
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0143 0.0324
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0001
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0215 0.0251
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0124 0.1139 0.1625
Onchocerca volvulus 0.0046 0.0328 0.0849
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0328 0.0283
Brugia malayi Pre-SET motif family protein 0.0036 0.0224 0.0332
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0098 0.0051
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.0328 0.0419
Echinococcus granulosus serotonin receptor 0.0046 0.0328 0.0419
Leishmania major GTP-binding protein, putative 0.0026 0.0116 0.0635
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0116 0.0635
Toxoplasma gondii hypothetical protein 0.0085 0.0729 1
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0047 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0147 0.0218
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0587 0.0804
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.0328 0.0419
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0469 0.0629
Echinococcus granulosus Protein patched homolog 1 0.0051 0.038 0.0496
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.0328 0.0283
Schistosoma mansoni neuropeptide receptor 0.0046 0.0328 0.0419
Echinococcus multilocularis serotonin receptor 0.0046 0.0328 0.0283
Schistosoma mansoni hypothetical protein 0.0046 0.0328 0.0419
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0212 0.1508
Echinococcus granulosus neuropeptide receptor 0.0046 0.0328 0.0419
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0054 0.5
Schistosoma mansoni myosin xvIII 0.0046 0.0328 0.0419
Echinococcus granulosus orexin receptor type 2 0.0046 0.0328 0.0419
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0129 0.1188 0.5335
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0328 0.0419
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0215 0.057
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0098 0.1294
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0047 0.0001
Brugia malayi RNA, U transporter 1 0.0099 0.0877 0.1296
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0054 0.0177
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0124 0.1139 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0328 0.0283
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0437 0.0582
Loa Loa (eye worm) hypothetical protein 0.0062 0.0499 0.0673
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus multilocularis orexin receptor type 2 0.0046 0.0328 0.0283
Plasmodium falciparum importin beta, putative 0.0035 0.0212 0.4219
Mycobacterium ulcerans hypothetical protein 0.0029 0.0147 0.5795
Brugia malayi Dopamine receptor 0.0046 0.0328 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0328 0.0283
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0085 0.0729 0.6245
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0215 0.0759
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0072 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0469 0.0693
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0276 0.5874
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0001
Brugia malayi glutathione reductase 0.0057 0.0437 0.0646
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0046 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0469 0.0693
Schistosoma mansoni hypothetical protein 0.0041 0.0273 0.0338
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0328 0.0419
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0147 0.5795
Schistosoma mansoni hypothetical protein 0.0046 0.0328 0.0419
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0054 0.0101
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0212 0.0166
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0328 0.0283
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0147 0.5795
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0276 0.5874
Onchocerca volvulus 0.0046 0.0328 0.0849
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0116 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0211 0.0244
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0224 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Plasmodium vivax SET domain protein, putative 0.0036 0.0224 0.4546
Brugia malayi Serotonin receptor 0.0046 0.0328 0.0485
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0212 0.1508
Onchocerca volvulus 0.0046 0.0328 0.0849
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.0328 0.0283
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0328 0.0419
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1327 0.1906
Onchocerca volvulus 0.0036 0.0224 0.0467
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0314 0.0398
Echinococcus multilocularis expressed conserved protein 0.0112 0.1008 0.0966
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0047 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0437 0.0393
Onchocerca volvulus 0.0035 0.0215 0.0434
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.006 0.003
Onchocerca volvulus 0.0046 0.0328 0.0849
Brugia malayi jmjC domain containing protein 0.0019 0.0047 0.007
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0276 0.2099
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.0328 0.0419
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0147 0.092
Schistosoma mansoni amine GPCR 0.0046 0.0328 0.0419
Onchocerca volvulus 0.0046 0.0328 0.0849
Schistosoma mansoni opsin-like receptor 0.0046 0.0328 0.0419
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2815 1
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.0328 0.0419
Schistosoma mansoni cellular tumor antigen P53 0.006 0.047 0.063
Brugia malayi Augmenter of liver regeneration 0.0041 0.0276 0.0408
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0054 0.0063
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0215 0.1542
Leishmania major importin beta-1 subunit, putative 0.0028 0.0143 0.0883
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0215 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0328 0.0419
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.0328 0.0485
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0054 0.0008
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.0328 0.0283
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.0328 0.0485
Onchocerca volvulus 0.0029 0.0147 0.0184
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.0276 0.0342
Brugia malayi ORL1-like opioid receptor 0.0046 0.0328 0.0485
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.038 0.0335
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0215 0.1542
Brugia malayi jmjC domain containing protein 0.0071 0.0587 0.0867
Leishmania major hypothetical protein, conserved 0.0035 0.0215 0.1542
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.0328 0.0283
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0124 0.1139 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0116 0.007
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0076
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0276 0.3361
Brugia malayi Melatonin receptor type 1A 0.0046 0.0328 0.0485
Echinococcus multilocularis RUN 0.0024 0.0098 0.0051
Schistosoma mansoni rab6-interacting 0.0024 0.0098 0.0076
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0224 0.0265
Loa Loa (eye worm) hypothetical protein 0.0051 0.038 0.0496
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0667 0.6766 1
Schistosoma mansoni amine GPCR 0.0046 0.0328 0.0419
Schistosoma mansoni loxhd1 0.0024 0.0098 0.0076
Schistosoma mansoni ran 0.0026 0.0116 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0328 0.0283
Schistosoma mansoni neuropeptide receptor 0.0046 0.0328 0.0419
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0276 0.2099
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0147 0.092
Mycobacterium leprae Probable lipase LipE 0.0035 0.0215 0.057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0314 0.0398
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni lipoxygenase 0.01 0.0883 0.1245
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0328 0.0419
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0328 0.0283
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0085 0.0729 0.6245
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.0328 0.0283
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0215 0.4314
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0215 0.0759
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0437 0.1802
Mycobacterium ulcerans lipase LipD 0.0035 0.0215 1
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0587 0.0804
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0129 0.1188 0.5335
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0276 0.2099
Mycobacterium tuberculosis Probable dehydrogenase 0.0129 0.1188 0.5335
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0215 0.1542
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0147 0.0322
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.0328 0.0283
Schistosoma mansoni lipoxygenase 0.0142 0.1327 0.1906
Onchocerca volvulus 0.0046 0.0328 0.0849
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0224 0.0265
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0328 0.0419
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0437 0.3574
Brugia malayi Dopamine receptor protein 1 0.0046 0.0328 0.0485
Schistosoma mansoni ran 0.0026 0.0116 0.0104
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Onchocerca volvulus 0.0046 0.0328 0.0849
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0085 0.0729 0.6245
Brugia malayi beta-lactamase family protein 0.0035 0.0215 0.0318
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0098 0.1294
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0328 0.0419
Mycobacterium ulcerans beta-lactamase 0.0035 0.0215 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.0328 0.0419
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.0328 0.0485
Loa Loa (eye worm) hypothetical protein 0.0029 0.0147 0.015
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0124 0.1139 0.1097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0063
Plasmodium falciparum glutathione reductase 0.0057 0.0437 1
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0328 0.0283
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0215 0.0759
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0328 0.0283
Toxoplasma gondii ABC1 family protein 0.0035 0.0215 0.2469
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0143 0.1338 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0273 0.2677 0.3915
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0328 0.0419
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.0328 0.0283
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0328 0.0419
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.0328 0.0419
Schistosoma mansoni protein arginine n-methyltransferase 0.0124 0.1139 0.1625
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Plasmodium vivax importin-beta 2, putative 0.0035 0.0212 0.4219
Brugia malayi AKH receptor 0.0046 0.0328 0.0485
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1612 0.2329
Brugia malayi Importin beta-1 subunit 0.0035 0.0212 0.0313
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0328 0.0283
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0054 0.0101
Echinococcus multilocularis histone h3 methyltransferase 0.0667 0.6766 0.6751
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0072 0.1147
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0054 0.0063
Onchocerca volvulus 0.0046 0.0328 0.0849
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0143 0.0324
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0328 0.0283
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0147 0.5795
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Schistosoma mansoni hypothetical protein 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0054 0.0063
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0147 0.5795
Echinococcus granulosus protein arginine N methyltransferase 7 0.0124 0.1139 0.1625
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0328 0.0283
Echinococcus granulosus RUN 0.0024 0.0098 0.0076
Onchocerca volvulus 0.0046 0.0328 0.0849
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0215 0.0251
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.0328 0.0419
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0143 0.1338 0.6037
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0054 0.0063
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus granulosus allatostatin A receptor 0.0046 0.0328 0.0419
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Schistosoma mansoni hypothetical protein 0.0049 0.036 0.0467
Mycobacterium tuberculosis Conserved protein 0.0035 0.0215 0.0759
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0328 0.0283
Schistosoma mansoni biogenic amine receptor 0.0046 0.0328 0.0419
Brugia malayi hypothetical protein 0.0024 0.0098 0.0144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0314 0.0398
Onchocerca volvulus 0.0046 0.0328 0.0849
Schistosoma mansoni hypothetical protein 0.0049 0.036 0.0467
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0314 0.0398
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0224 0.0265
Schistosoma mansoni importin beta-1 0.0035 0.0212 0.0246
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0276 0.3361
Echinococcus granulosus expressed conserved protein 0.0112 0.1008 0.1431
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0587 0.0543
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0314 0.0398
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0328 0.0283
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0116 0.0635
Loa Loa (eye worm) hypothetical protein 0.006 0.0469 0.0629
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.0276 0.0342
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Schistosoma mansoni biogenic amine receptor 0.0046 0.0328 0.0419
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.0328 0.0485
Echinococcus granulosus tumor protein p63 0.0408 0.408 0.6002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.006 0.003
Onchocerca volvulus 0.0035 0.0215 0.0434
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0129 0.1188 0.5335
Schistosoma mansoni opsin-like receptor 0.0046 0.0328 0.0419
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0063
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0251
Echinococcus multilocularis sex peptide receptor 0.0046 0.0328 0.0283
Echinococcus multilocularis tumor protein p63 0.0408 0.408 0.4052
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0328 0.0283
Echinococcus granulosus hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0328 0.0419
Brugia malayi sulfakinin receptor protein 0.0046 0.0328 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0328 0.0419
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0276 0.2099
Leishmania major hypothetical protein, conserved 0.0085 0.0729 0.6245
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0328 0.0419
Onchocerca volvulus 0.0046 0.0328 0.0849
Echinococcus granulosus somatostatin receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus multilocularis snurportin 1 0.0372 0.3703 0.3674
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0039
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0215 0.0759
Brugia malayi jmjC domain containing protein 0.0019 0.0047 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Schistosoma mansoni neuropeptide receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0328 0.0419
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.0328 0.0849
Trypanosoma brucei trypanothione reductase 0.0057 0.0437 0.3574
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus multilocularis somatostatin receptor 0.0046 0.0328 0.0283
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0314 0.0464
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Onchocerca volvulus 0.0046 0.0328 0.0849
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.0328 0.0283
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0215 0.017
Brugia malayi follicle stimulating hormone receptor 0.0273 0.2677 0.3957
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0129 0.1188 0.8746
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0147 0.092
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0047 0.0001
Echinococcus multilocularis protein patched 0.0051 0.038 0.0335
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0251
Schistosoma mansoni rab6-interacting 0.0024 0.0098 0.0076
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0147 0.5795
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0063
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0224 0.2601
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.0328 0.0419
Echinococcus granulosus sex peptide receptor 0.0046 0.0328 0.0419
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0054 0.0063
Schistosoma mansoni neuropeptide receptor 0.0046 0.0328 0.0419
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.006 0.003
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus multilocularis allatostatin A receptor 0.0046 0.0328 0.0283
Schistosoma mansoni biogenic amine receptor 0.0046 0.0328 0.0419
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0116 0.1017
Brugia malayi jmjC domain containing protein 0.0071 0.0587 0.0867
Schistosoma mansoni amine GPCR 0.0046 0.0328 0.0419
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0124 0.1139 1
Onchocerca volvulus 0.0046 0.0328 0.0849
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.0328 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.038 0.1179
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0085 0.0729 0.6245
Plasmodium falciparum thioredoxin reductase 0.0057 0.0437 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1102 0.1571
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0587 0.0543
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0047 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0328 0.0283
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1612 0.1573
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0047 0.0001
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.0328 0.0419
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0116 0.1777
Mycobacterium tuberculosis Probable reductase 0.0129 0.1188 0.5335
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0147 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0328 0.0283
Schistosoma mansoni histone J3 methyltransferase 0.0667 0.6766 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0047 0.0001
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0328 0.0283
Echinococcus granulosus histone h3 methyltransferase 0.0667 0.6766 1
Brugia malayi Serotonin receptor 0.0046 0.0328 0.0485
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0047 0.0001
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0098 0.0076
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Treponema pallidum NADH oxidase 0.002 0.0054 0.5
Onchocerca volvulus 0.0046 0.0328 0.0849
Mycobacterium tuberculosis Conserved protein 0.0035 0.0215 0.0759
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0147 0.0322
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0224 0.0179
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0328 0.0283
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni opsin-like receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0328 0.0419
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0143 0.1338 0.6037
Brugia malayi RE15519p 0.0046 0.0328 0.0485
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0328 0.0283
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0328 0.0283
Echinococcus granulosus g protein coupled receptor 0.0046 0.0328 0.0419
Onchocerca volvulus 0.0046 0.0328 0.0849
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0215 0.0584
Leishmania major trypanothione reductase 0.0057 0.0437 0.3574
Schistosoma mansoni hypothetical protein 0.0372 0.3703 0.5442
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0328 0.0419
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0124 0.1139 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0063
Schistosoma mansoni amine GPCR 0.0046 0.0328 0.0419
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0215 0.0251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.006 0.003
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0046 0.0068
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0328 0.0419
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0587 0.0804
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0063
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0273 0.0404
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0039
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.0276 0.0231
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.0328 0.0283
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0098 0.0076
Onchocerca volvulus 0.0046 0.0328 0.0849
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0147 0.0218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0314 0.0269
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0215 0.0759
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0328 0.0419
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0215 1
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.0328 0.0419
Echinococcus granulosus g protein coupled receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0039
Echinococcus granulosus neuropeptide s receptor 0.0046 0.0328 0.0419
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.0328 0.0419
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0328 0.0283
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.0328 0.0283
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0215 0.0584
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0251
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0147 0.044
Brugia malayi G protein-coupled receptor 0.0046 0.0328 0.0485
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0265
Schistosoma mansoni hypothetical protein 0.0046 0.0328 0.0419
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.0328 0.0419
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0147 0.044
Schistosoma mansoni hypothetical protein 0.0049 0.036 0.0467
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0215 0.0318
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.0328 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0314 0.0398
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0215 0.0251
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.0328 0.0283
Brugia malayi Dopamine receptor protein 2 0.0046 0.0328 0.0485
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0116 0.0104
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0098 0.0051
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0047 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0129 0.1188 0.5335
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0212 0.2415
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.0328 0.0485
Onchocerca volvulus 0.0035 0.0215 0.0434
Echinococcus granulosus fmrfamide receptor 0.0046 0.0328 0.0419
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0054 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0039
Brugia malayi beta-lactamase 0.0035 0.0215 0.0318
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0328 0.0419
Echinococcus granulosus g protein coupled receptor 0.0046 0.0328 0.0419
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0047 0.0001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0054 0.0063
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0047 0.0001
Brugia malayi jmjC domain containing protein 0.0019 0.0047 0.007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.218 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0054 0.008
Brugia malayi GnHR receptor homolog 0.0046 0.0328 0.0485
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0328 0.0419
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0328 0.0283
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.0328 0.0485
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0054 0.0011
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0047 0.0001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.0328 0.0419
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0072 0.0652
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0147 0.5795
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.0328 0.0485
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0047 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0224 0.0179
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0047 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0328 0.0419
Plasmodium falciparum glutathione reductase 0.002 0.0054 0.0177
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.0328 0.0419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0328 0.0419
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0047 0.0001
Brugia malayi hypothetical protein 0.0046 0.0328 0.0485
Echinococcus granulosus phd:f box containing protein 0.0019 0.0047 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0143 0.0324
Loa Loa (eye worm) hypothetical protein 0.0029 0.0147 0.015
Echinococcus granulosus importin subunit beta 1 0.0035 0.0212 0.0246
Brugia malayi larval opioid receptor 0.0046 0.0328 0.0485
Entamoeba histolytica hypothetical protein 0.0028 0.0143 0.028
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0215 0.0759
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0147 0.5795
Schistosoma mansoni adenoreceptor 0.0046 0.0328 0.0419
Trichomonas vaginalis esterase, putative 0.0035 0.0215 0.0584
Brugia malayi Thioredoxin reductase 0.0057 0.0437 0.0646
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.0328 0.0419
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0054 0.0177
Onchocerca volvulus 0.0046 0.0328 0.0849
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0328 0.0419
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0143 0.0883
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0039
Trichomonas vaginalis ran, putative 0.0026 0.0116 0.0226
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1083 0.16
Loa Loa (eye worm) glutathione reductase 0.0057 0.0437 0.0582
Loa Loa (eye worm) hypothetical protein 0.0046 0.0328 0.0419
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0328 0.0419
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0147 0.0218
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.0328 0.0849
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0047 0.0001
Brugia malayi jmjC domain containing protein 0.0019 0.0047 0.007
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.0328 0.0419
Schistosoma mansoni histamine h1 receptor 0.0046 0.0328 0.0419
Schistosoma mansoni hypothetical protein 0.0049 0.036 0.0467
Loa Loa (eye worm) hypothetical protein 0.0029 0.0147 0.015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0116 0.0104
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0251
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0328 0.0419
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0328 0.0283
Brugia malayi neuropeptide F receptor 0.0046 0.0328 0.0485
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.0328 0.0283
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.0328 0.0283
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0054 0.0063
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0251
Schistosoma mansoni amine GPCR 0.0046 0.0328 0.0419
Brugia malayi G-protein coupled receptor 0.0046 0.0328 0.0485
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0054 0.0063
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1327 0.1287
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1083 0.1543
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0437 0.0582
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0338
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.038 0.0496
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0667 0.6766 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0251
Brugia malayi beta-lactamase family protein 0.0035 0.0215 0.0318

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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