Detailed information for compound 1405948

Basic information

Technical information
  • TDR Targets ID: 1405948
  • Name: 5-methylisoquinolino[3,2-b]quinazoline-11,13- dione
  • MW: 276.289 | Formula: C17H12N2O2
  • H donors: 0 H acceptors: 2 LogP: 2.92 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1c2ccccc2cc2n1c(=O)c1ccccc1n2C
  • InChi: 1S/C17H12N2O2/c1-18-14-9-5-4-8-13(14)17(21)19-15(18)10-11-6-2-3-7-12(11)16(19)20/h2-10H,1H3
  • InChiKey: YORDSWSHXGPFLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-methylisoquinolino[3,2-b]quinazoline-11,13-quinone
  • Oprea1_794126
  • MLS000094953
  • SMR000030507
  • Oprea1_301766

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens galactokinase 1 Starlite/ChEMBL No references
Homo sapiens ubiquitin-like modifier activating enzyme 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens SUMO1 activating enzyme subunit 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Theileria parva ubiquitin-protein ligase, putative Get druggable targets OG5_127838 All targets in OG5_127838
Babesia bovis conserved hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative Get druggable targets OG5_127838 All targets in OG5_127838
Toxoplasma gondii ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Brugia malayi ThiF family protein Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium knowlesi SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma cruzi ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium vivax ubiquitin activating enzyme, putative Get druggable targets OG5_128859 All targets in OG5_128859
Schistosoma japonicum ko:K10684 ubiquitin-like 1-activating enzyme E1 A, putative Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium parvum SUMO-1 activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Treponema pallidum galactokinase Get druggable targets OG5_129789 All targets in OG5_129789
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Babesia bovis ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium vivax SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania major ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania mexicana ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Giardia lamblia Ubiquitin-activating enzyme E1 1 Get druggable targets OG5_127838 All targets in OG5_127838
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus galactokinase Get druggable targets OG5_129789 All targets in OG5_129789
Trypanosoma cruzi galactokinase-like protein, putative Get druggable targets OG5_129789 All targets in OG5_129789
Leishmania mexicana galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium knowlesi SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium berghei SUMO-activating enzyme subunit 1, putative Get druggable targets OG5_128859 All targets in OG5_128859
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans similar to Uba1 (Ub-activating enzyme) Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma mansoni ubiquitin-activating enzyme E1b Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Schistosoma japonicum ko:K10685 ubiquitin-like 1-activating enzyme E1 B, putative Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania major galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii SUMO-1 activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Neospora caninum AFR138Wp, related Get druggable targets OG5_127838 All targets in OG5_127838
Leishmania infantum galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Echinococcus granulosus sumo-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis galactokinase Get druggable targets OG5_129789 All targets in OG5_129789
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Loa Loa (eye worm) ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis SUMO activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium berghei SUMO-activating enzyme subunit 2, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense ubiquitin-activating enzyme E1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Plasmodium falciparum SUMO-activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus multilocularis SUMO activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Brugia malayi ThiF family protein Get druggable targets OG5_127838 All targets in OG5_127838
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Entamoeba histolytica ubiquitin-activating enzyme, putative Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma cruzi galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Plasmodium falciparum SUMO-activating enzyme subunit 1 Get druggable targets OG5_128859 All targets in OG5_128859
Candida albicans similar to S. cerevisiae AOS1 (YPR180W) which mediates conjugation of ubiquitin-like Smt3p (sumoylation) to target proteins Get druggable targets OG5_128859 All targets in OG5_128859
Trypanosoma brucei galactokinase-like protein, putative Get druggable targets OG5_129789 All targets in OG5_129789
Entamoeba histolytica galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Theileria parva hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum hypothetical protein Get druggable targets OG5_128859 All targets in OG5_128859
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis ubiquitin-activating enzyme-like protein Get druggable targets OG5_127838 All targets in OG5_127838
Trypanosoma brucei gambiense ubiquitin-activating enzyme e1, putative Get druggable targets OG5_127838 All targets in OG5_127838
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi galactokinase, putative Get druggable targets OG5_129789 All targets in OG5_129789
Plasmodium yoelii related to ubiquitin-activating enzyme homolog UBA2-related Get druggable targets OG5_127838 All targets in OG5_127838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) Get druggable targets OG5_129789 All targets in OG5_129789
Cryptosporidium hominis SUMO-1 activating enzyme subunit 2 Get druggable targets OG5_127838 All targets in OG5_127838
Mycobacterium ulcerans galactokinase Get druggable targets OG5_129789 All targets in OG5_129789
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani galactokinase-like protein Get druggable targets OG5_129789 All targets in OG5_129789
Schistosoma mansoni sumo-1-activating enzyme E1a Get druggable targets OG5_128859 All targets in OG5_128859
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Brugia malayi galactokinase family protein galactokinase 1 392 aa 405 aa 30.1 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii beta tubulin 0.0022 0.0019 0.0734
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Brugia malayi sulfakinin receptor protein 0.0099 0.0531 0.0531
Brugia malayi Cytochrome P450 family protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0303 0.0303
Schistosoma mansoni histamine h1 receptor 0.0099 0.0531 0.0531
Brugia malayi GnHR receptor homolog 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0019 0.0185
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0058 0.026 0.026
Echinococcus granulosus allatostatin A receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus multilocularis orexin receptor type 2 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Trypanosoma brucei galactokinase-like protein, putative 0.0042 0.0154 0.3929
Schistosoma mansoni opsin-like receptor 0.0099 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0019 0.0729
Loa Loa (eye worm) hypothetical protein 0.018 0.1081 0.1081
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus multilocularis G-protein coupled receptor, putative 0.0099 0.0531 0.0531
Brugia malayi RE15519p 0.0099 0.0531 0.0531
Echinococcus granulosus sex peptide receptor 0.0099 0.0531 0.0531
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0019 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0019 0.0185
Echinococcus granulosus neuropeptide receptor 0.0099 0.0531 0.0531
Brugia malayi G protein-coupled receptor F59B2.13 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0019 0.0185
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0099 0.0531 0.0531
Mycobacterium leprae putative cytochrome p450 0.0022 0.0019 0.0185
Brugia malayi ThiF family protein 0.0038 0.0126 0.0126
Echinococcus granulosus neuropeptide receptor A26 0.0099 0.0531 0.0531
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0038 0.0126 0.0126
Echinococcus granulosus 7tm_1 domain containing protein 0.0099 0.0531 0.0531
Schistosoma mansoni biogenic amine (5HT) receptor 0.0099 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0019 0.0185
Loa Loa (eye worm) G-protein coupled receptor 0.0099 0.0531 0.0531
Toxoplasma gondii beta-tubulin, putative 0.0022 0.0019 0.0734
Echinococcus multilocularis neuropeptide Y receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis g-protein coupled receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Schistosoma mansoni opsin-like receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.0367 0.0367
Echinococcus multilocularis neuropeptide FF receptor 2 0.0099 0.0531 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Schistosoma mansoni neuropeptide receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0099 0.0531 0.0531
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0038 0.0126 0.0126
Toxoplasma gondii hypothetical protein 0.0058 0.026 1
Schistosoma mansoni biogenic amine receptor 0.0099 0.0531 0.0531
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0099 0.0531 0.0531
Brugia malayi larval opioid receptor 0.0099 0.0531 0.0531
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0019 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Loa Loa (eye worm) CYP4Cod1 0.0078 0.0391 0.0391
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2241 0.5024
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0019 0.0485
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0099 0.0531 0.0531
Loa Loa (eye worm) BEN-1 protein 0.0022 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0019 0.0185
Loa Loa (eye worm) tubulin beta-2A chain 0.0022 0.0019 0.0019
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus serotonin receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) cytochrome P450 0.0022 0.0019 0.0019
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0019 0.0185
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1028 1
Echinococcus granulosus tm gpcr rhodopsin 0.0099 0.0531 0.0531
Echinococcus multilocularis serotonin receptor 0.0099 0.0531 0.0531
Giardia lamblia Beta tubulin 0.0022 0.0019 0.0043
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0019 0.0185
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0019 0.0185
Echinococcus multilocularis galactokinase 0.0064 0.0298 0.0298
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0099 0.0531 0.0531
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0334 0.0334
Loa Loa (eye worm) neuropeptide F receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0099 0.0531 0.0531
Schistosoma mansoni biogenic amine receptor 0.0099 0.0531 0.0531
Brugia malayi ThiF family protein 0.0058 0.026 0.026
Entamoeba histolytica galactokinase, putative 0.0064 0.0298 0.1254
Schistosoma mansoni amine GPCR 0.0099 0.0531 0.0531
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0099 0.0531 0.0531
Plasmodium vivax ubiquitin activating enzyme, putative 0.0058 0.026 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0022 0.0019 0.0019
Trypanosoma cruzi galactokinase, putative 0.0056 0.0242 0.6189
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0019 0.0185
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Trypanosoma brucei beta tubulin 0.0022 0.0019 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0019 0.0185
Schistosoma mansoni cytochrome P450 0.0022 0.0019 0.0019
Trypanosoma cruzi beta tubulin, putative 0.0022 0.0019 0.0488
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2241 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0099 0.0531 0.0531
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0013 0.0013
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Echinococcus multilocularis neuropeptide receptor 0.0099 0.0531 0.0531
Trichomonas vaginalis galactokinase, putative 0.003 0.0068 0.0222
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0099 0.0531 0.0531
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Trypanosoma cruzi galactokinase, putative 0.0064 0.0298 0.7612
Schistosoma mansoni tubulin subunit beta 0.0022 0.0019 0.0019
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0038 0.0126 0.4444
Echinococcus granulosus g-protein coupled receptor 0.0099 0.0531 0.0531
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0334 0.855
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0334 0.0334
Echinococcus multilocularis N acetylgalactosamine kinase 0.003 0.0068 0.0068
Brugia malayi AKH receptor 0.0099 0.0531 0.0531
Trichomonas vaginalis galactokinase, putative 0.003 0.0068 0.0222
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0391 0.0391
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0099 0.0531 0.0531
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0099 0.0531 0.0531
Trichomonas vaginalis galactokinase, putative 0.003 0.0068 0.0222
Brugia malayi beta-tubulin, identical 0.0022 0.0019 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Schistosoma mansoni biogenic amine (5HT) receptor 0.0099 0.0531 0.0531
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Echinococcus granulosus hypothetical protein 0.0099 0.0531 0.0531
Toxoplasma gondii beta-1 tubulin, putative 0.0022 0.0019 0.0734
Echinococcus granulosus rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Echinococcus granulosus neuropeptide Y receptor 0.0099 0.0531 0.0531
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0019 0.0019
Brugia malayi G-protein coupled receptor 0.0099 0.0531 0.0531
Schistosoma mansoni biogenic amine receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0019 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis neuropeptide s receptor 0.0099 0.0531 0.0531
Echinococcus granulosus biogenic amine 5HT receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0019 0.0485
Echinococcus multilocularis g protein coupled receptor 0.0099 0.0531 0.0531
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0334 0.1417
Schistosoma mansoni neuropeptide receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0019 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0019 0.0185
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus orexin receptor type 2 0.0099 0.0531 0.0531
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0099 0.0531 0.0531
Echinococcus multilocularis fmrfamide receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus tm gpcr rhodopsin 0.0099 0.0531 0.0531
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0058 0.026 0.026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0099 0.0531 0.0531
Brugia malayi Muscleblind-like protein 0.018 0.1081 0.1081
Echinococcus multilocularis muscleblind protein 1 0.018 0.1081 0.1081
Brugia malayi Dopamine receptor protein 2 0.0099 0.0531 0.0531
Brugia malayi Cytochrome P450 family protein 0.0022 0.0019 0.0019
Echinococcus multilocularis beta tubulin 0.0022 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0019 0.0185
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0019 0.0185
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0019 0.0019
Brugia malayi neuropeptide F receptor 0.0099 0.0531 0.0531
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0013 0.0013
Echinococcus multilocularis serotonin receptor 0.0099 0.0531 0.0531
Echinococcus granulosus muscleblind protein 0.018 0.1081 0.1081
Echinococcus granulosus rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Echinococcus multilocularis g protein coupled receptor 0.0099 0.0531 0.0531
Echinococcus granulosus 7TM GPCR rhodopsin 0.0099 0.0531 0.0531
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.003 0.0068 0.2631
Echinococcus multilocularis G protein coupled receptor 139 0.0099 0.0531 0.0531
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0099 0.0531 0.0531
Loa Loa (eye worm) neuropeptide F receptor 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0019 0.0185
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0099 0.0531 0.0531
Brugia malayi follicle stimulating hormone receptor 0.0099 0.0531 0.0531
Echinococcus granulosus rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2241 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus dro:myosuppressin receptor 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0019 0.0185
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0038 0.0126 0.0126
Echinococcus granulosus tm gpcr rhodopsin 0.0099 0.0531 0.0531
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0019 0.0485
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0019 0.0185
Echinococcus multilocularis somatostatin receptor 0.0099 0.0531 0.0531
Echinococcus granulosus rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2241 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0019 0.0185
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0013 0.0013
Schistosoma mansoni tubulin subunit beta 0.0022 0.0019 0.0019
Echinococcus multilocularis g protein coupled receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0019 0.0185
Echinococcus granulosus tachykinin peptides receptor 99D 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0019 0.0185
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Schistosoma mansoni neuropeptide receptor 0.0099 0.0531 0.0531
Echinococcus granulosus neuropeptide Y receptor 0.0099 0.0531 0.0531
Echinococcus granulosus N acetylgalactosamine kinase 0.003 0.0068 0.0068
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0301
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) galactokinase 0.003 0.0068 0.0068
Brugia malayi Tubulin beta-1 chain 0.0022 0.0019 0.0019
Loa Loa (eye worm) ThiF family protein 0.0038 0.0126 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0019 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Echinococcus granulosus rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0099 0.0531 0.0531
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0019 0.0185
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0334 0.3253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2241 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) tubulin beta-1 chain 0.0022 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0099 0.0531 0.0531
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0099 0.0531 0.0531
Brugia malayi Melatonin receptor type 1A 0.0099 0.0531 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0019 0.0185
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.009 0.2307
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0019 0.0185
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0099 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0099 0.0531 0.0531
Brugia malayi Tachykinin-like peptides receptor 99D 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0019 0.0185
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0019 0.0185
Brugia malayi putative neuropeptide receptor NPR1 0.0099 0.0531 0.0531
Echinococcus granulosus g protein coupled receptor 0.0099 0.0531 0.0531
Brugia malayi Serotonin receptor 0.0099 0.0531 0.0531
Giardia lamblia Beta tubulin 0.0022 0.0019 0.0043
Trypanosoma brucei beta tubulin 0.0022 0.0019 0.0488
Schistosoma mansoni tubulin subunit beta 0.0022 0.0019 0.0019
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Echinococcus granulosus neuropeptide FF receptor 2 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0019 0.0185
Loa Loa (eye worm) melatonin receptor type 1A 0.0099 0.0531 0.0531
Toxoplasma gondii ThiF family protein 0.0038 0.0126 0.4852
Loa Loa (eye worm) beta-tubulin 0.0022 0.0019 0.0019
Echinococcus granulosus G protein coupled receptor 139 0.0099 0.0531 0.0531
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0038 0.0126 0.4444
Trypanosoma cruzi galactokinase-like protein, putative 0.0056 0.0242 0.6189
Echinococcus granulosus beta tubulin 0.0022 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0019 0.0185
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0019 0.0185
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus multilocularis neuropeptides capa receptor 0.0099 0.0531 0.0531
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0013 0.0013
Leishmania major ubiquitin-activating enzyme-like protein 0.0038 0.0126 0.3226
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0099 0.0531 0.0531
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus multilocularis sex peptide receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Mycobacterium ulcerans galactokinase 0.0064 0.0298 0.2897
Brugia malayi cytochrome P450 0.0022 0.0019 0.0019
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus tubulin subunit beta 0.0022 0.0019 0.0019
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0019 0.0485
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0099 0.0531 0.0531
Schistosoma mansoni growth hormone secretagogue receptor 0.0099 0.0531 0.0531
Brugia malayi Dopamine receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Leishmania major cytochrome p450-like protein 0.0078 0.0391 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0022 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2241 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.0367 0.0367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0055 0.0241 0.0241
Loa Loa (eye worm) tubulin beta-4 chain 0.0022 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Loa Loa (eye worm) tubulin beta chain 0.0022 0.0019 0.0019
Giardia lamblia Ceramide glucosyltransferase 0.0683 0.4461 1
Trypanosoma brucei beta tubulin 0.0022 0.0019 0.0488
Schistosoma mansoni amine GPCR 0.0099 0.0531 0.0531
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Giardia lamblia Beta tubulin 0.0022 0.0019 0.0043
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0099 0.0531 0.0531
Echinococcus granulosus neuropeptide receptor 0.0099 0.0531 0.0531
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0019 0.0185
Echinococcus granulosus g protein coupled receptor 0.0099 0.0531 0.0531
Leishmania major cytochrome p450-like protein 0.0022 0.0019 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0099 0.0531 0.0531
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0334 0.1417
Schistosoma mansoni amine GPCR 0.0099 0.0531 0.0531
Loa Loa (eye worm) G-protein coupled receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.018 0.1081 0.1081
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0099 0.0531 0.0531
Trichomonas vaginalis galactokinase, putative 0.003 0.0068 0.0222
Echinococcus granulosus g protein coupled receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Schistosoma mansoni neuropeptide F-like receptor 0.0099 0.0531 0.0531
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Echinococcus multilocularis tubulin beta 1 chain 0.0022 0.0019 0.0019
Echinococcus granulosus tubulin beta 1 chain 0.0022 0.0019 0.0019
Echinococcus multilocularis beta tubulin 0.0022 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2241 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2241 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Brugia malayi ORL1-like opioid receptor 0.0099 0.0531 0.0531
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Echinococcus multilocularis allatostatin A receptor 0.0099 0.0531 0.0531
Brugia malayi Cytochrome P450 family protein 0.0078 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Schistosoma mansoni neuropeptide receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0013 0.0013
Echinococcus multilocularis neuropeptides capa receptor 0.0099 0.0531 0.0531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2241 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0019 0.0185
Echinococcus multilocularis neuropeptide receptor 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0019 0.0185
Echinococcus multilocularis fmrfamide receptor 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0019 0.0185
Treponema pallidum galactokinase 0.0056 0.0242 0.108
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0413 0.0413
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.0367 0.0367
Schistosoma mansoni opsin-like receptor 0.0099 0.0531 0.0531
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2241 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0019 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2241 1
Schistosoma mansoni myosin xvIII 0.0099 0.0531 0.0531
Echinococcus granulosus somatostatin receptor 0.0099 0.0531 0.0531
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0334 0.3253
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0019 0.0185
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0099 0.0531 0.0531
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0019 0.0185
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0019 0.0185
Schistosoma mansoni adenoreceptor 0.0099 0.0531 0.0531
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0099 0.0531 0.0531
Leishmania major galactokinase-like protein 0.0064 0.0298 0.7612
Trypanosoma cruzi galactokinase, putative 0.0064 0.0298 0.7612
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.0367 0.0367
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.0064 0.0298 0.2897
Echinococcus granulosus galactokinase 0.0064 0.0298 0.0298
Schistosoma mansoni tubulin subunit beta 0.0022 0.0019 0.0019
Trypanosoma brucei beta tubulin 0.0022 0.0019 0.0488
Echinococcus granulosus biogenic amine 5HT receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis neuropeptide Y receptor 0.0099 0.0531 0.0531
Leishmania major cytochrome p450-like protein 0.0022 0.0019 0.0485
Trypanosoma brucei cytochrome P450, putative 0.0078 0.0391 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1028 1
Schistosoma mansoni tubulin subunit beta 0.0022 0.0019 0.0019
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0038 0.0126 0.3226
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2241 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0058 0.026 1
Echinococcus multilocularis 0.0022 0.0019 0.0019
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0099 0.0531 0.0531
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0058 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0099 0.0531 0.0531
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0058 0.026 0.026
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1028 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0099 0.0531 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0013 0.0013
Schistosoma mansoni neuropeptide F-like receptor 0.0099 0.0531 0.0531
Loa Loa (eye worm) BEN-1 protein 0.0022 0.0019 0.0019
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0099 0.0531 0.0531
Echinococcus granulosus fmrfamide receptor 0.0099 0.0531 0.0531
Schistosoma mansoni galactokinase 0.003 0.0068 0.0068
Brugia malayi Serotonin receptor 0.0099 0.0531 0.0531
Schistosoma mansoni amine GPCR 0.0099 0.0531 0.0531
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0019 0.0185
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0019 0.0185
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0099 0.0531 0.0531
Echinococcus granulosus neuropeptide s receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0099 0.0531 0.0531
Brugia malayi putative neuropeptide receptor 0.0099 0.0531 0.0531
Brugia malayi galactokinase family protein 0.003 0.0068 0.0068
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0078 0.0391 0.3805
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0019 0.0019
Echinococcus multilocularis muscleblind protein 0.018 0.1081 0.1081
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Brugia malayi hypothetical protein 0.0099 0.0531 0.0531
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0038 0.0126 0.3226
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0099 0.0531 0.0531
Echinococcus multilocularis tubulin subunit beta 0.0022 0.0019 0.0019
Loa Loa (eye worm) TYRA-2 protein 0.0099 0.0531 0.0531
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0099 0.0531 0.0531
Brugia malayi G-protein coupled receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6452 0.6452
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0391 1
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor A26 0.0099 0.0531 0.0531
Echinococcus granulosus neuropeptides capa receptor 0.0099 0.0531 0.0531
Brugia malayi Dopamine receptor protein 1 0.0099 0.0531 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0413 0.0413
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0391 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0019 0.0019
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0019 0.0019
Echinococcus granulosus beta tubulin 0.0022 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0019 0.0185
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0019 0.0185
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0053 0.0224 0.0224
Echinococcus granulosus alpha 1A adrenergic receptor 0.0099 0.0531 0.0531
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0099 0.0531 0.0531
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Schistosoma mansoni neuropeptide f receptor 76f 0.0099 0.0531 0.0531
Brugia malayi G protein-coupled receptor 0.0099 0.0531 0.0531
Schistosoma mansoni tubulin subunit beta 0.0022 0.0019 0.0019
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Brugia malayi neuropeptide F receptor 0.0099 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0099 0.0531 0.0531
Brugia malayi Cytochrome P450 family protein 0.0078 0.0391 0.0391
Leishmania major beta tubulin 0.0022 0.0019 0.0488
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0334 0.3253
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0013

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.28 uM PUBCHEM_BIOASSAY: AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2006, AID2011, AID2069, AID2614, AID2658] ChEMBL. No reference
IC50 (binding) = 10.9 uM PUBCHEM_BIOASSAY: uHTS HTRF assay for identification of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2011, AID2018, AID2069, AID2614, AID2658] ChEMBL. No reference
IC50 (binding) > 69.5 um PUBCHEM_BIOASSAY: TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2). (Class of assay: confirmatory) [Related pubchem assays: 794, 727, 810 ] ChEMBL. No reference
Potency (functional) = 1.2559 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10.5822 um PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Human Galactosidase (GALK). (Class of assay: confirmatory) [Related pubchem assays: 1868, 1379 ] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 24.9271 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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