TDR Targets

Basic information

Technical information

TDR Targets ID: 1411775
Name: 2-morpholin-4-yl-8-phenyl-6-(2-phenylethyl)pt eridin-7-one
MW: 413.472 | Formula: C24H23N5O2
H donors: 0 H acceptors: 3 LogP: 3.02 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=c1c(CCc2ccccc2)nc2c(n1c1ccccc1)nc(nc2)N1CCOCC1
InChi: 1S/C24H23N5O2/c30-23-20(12-11-18-7-3-1-4-8-18)26-21-17-25-24(28-13-15-31-16-14-28)27-22(21)29(23)19-9-5-2-6-10-19/h1-10,17H,11-16H2
InChiKey: QMFNADVJTJLHOS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-morpholino-8-phenyl-6-(2-phenylethyl)pteridin-7-one
2-morpholino-8-phenyl-6-(2-phenylethyl)-7-pteridinone
NCGC00012434
PCOP-827192

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	thyroid stimulating hormone receptor	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 1, subfamily A, polypeptide 2	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Brugia malayi	Cytochrome P450 family protein	cytochrome P450, family 1, subfamily A, polypeptide 2	516 aa	470 aa	26.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0041	0.0624	0.1438
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.1024	0.2451
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0244	0.0479
Brugia malayi	Cathepsin L-like precursor	0.0205	0.401	0.5332
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Trypanosoma brucei	calpain-like protein, putative	0.006	0.1024	0.2451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0624	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Schistosoma mansoni	peroxidasin	0.0103	0.1917	0.1917
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0018	0.015	0.024
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0829	0.1453
Brugia malayi	hypothetical protein	0.0103	0.1917	0.251
Brugia malayi	cathepsin L precursor	0.0041	0.0624	0.0767
Echinococcus granulosus	calpain 5	0.006	0.1024	0.1024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0624	0.0624
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Brugia malayi	Proteasome A-type and B-type family protein	0.0069	0.1207	0.1553
Trichomonas vaginalis	calpain, putative	0.0018	0.015	0.0128
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0014	0.0055	0.0055
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Leishmania major	hypothetical protein, conserved	0.0018	0.015	0.024
Mycobacterium leprae	Conserved hypothetical protein	0.0372	0.7473	1
Echinococcus granulosus	proteasome prosome macropain	0.0069	0.1207	0.1207
Trypanosoma brucei	calpain, putative	0.0018	0.015	0.024
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Trypanosoma brucei	Calpain-like protein 1.1	0.0018	0.015	0.024
Loa Loa (eye worm)	hypothetical protein	0.0048	0.076	0.1329
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0018	0.015	0.024
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0244	0.0244
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0205	0.401	0.401
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0205	0.401	0.401
Onchocerca volvulus	Cathepsin L homolog	0.0205	0.401	0.5332
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0014	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0313	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0303	0.0504
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0041	0.0624	0.1438
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0244	0.5
Loa Loa (eye worm)	cysteine protease	0.0205	0.401	0.7195
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0018	0.015	0.0128
Trypanosoma cruzi	cysteine peptidase, putative	0.0205	0.401	1
Mycobacterium tuberculosis	Conserved protein	0.0372	0.7473	1
Mycobacterium ulcerans	transglutaminase family protein	0.0372	0.7473	1
Plasmodium falciparum	serine repeat antigen 3	0.0041	0.0624	0.1438
Plasmodium vivax	vivapain-1	0.0107	0.1997	0.4909
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0051	0.0839	0.1983
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0107	0.1997	0.4909
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0771	0.1348
Schistosoma mansoni	calpain-7 (C02 family)	0.0067	0.1161	0.1161
Onchocerca volvulus		0.0041	0.0624	0.0767
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0244	0.0479
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Leishmania major	cathepsin L-like protease	0.0205	0.401	1
Plasmodium falciparum	serine repeat antigen 4	0.0041	0.0624	0.1438
Plasmodium falciparum	serine repeat antigen 1	0.0041	0.0624	0.1438
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0244	0.0255
Schistosoma mansoni	calpain C (C02 family)	0.006	0.1024	0.1024
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0018	0.015	0.024
Trypanosoma brucei	oligopeptidase b	0.0051	0.0839	0.1983
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0689	0.1199
Echinococcus granulosus	lamin	0.0026	0.0313	0.0313
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.1024	0.2451
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0041	0.0624	0.0767
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.1024	0.2451
Trypanosoma brucei	cysteine peptidase, putative	0.0018	0.015	0.024
Brugia malayi	Peroxidasin	0.0103	0.1917	0.251
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0167	0.3239	0.3239
Onchocerca volvulus	Peroxidase homolog	0.0103	0.1917	0.251
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0041	0.0624	0.0624
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Plasmodium vivax	vivapain-2	0.0205	0.401	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0041	0.0624	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0624	0.1082
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0041	0.0624	0.1438
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0034	0.0034
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Entamoeba histolytica	calpain family cysteine protease, putative	0.0018	0.015	0.024
Onchocerca volvulus		0.0372	0.7473	1
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0689	0.0689
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0081	0.1457	0.189
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.006	0.1024	0.2451
Entamoeba histolytica	cysteine protease, putative	0.0205	0.401	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0205	0.401	1
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0018	0.015	0.0128
Echinococcus multilocularis	geminin	0.0329	0.6576	0.6576
Echinococcus granulosus	histone acetyltransferase MYST2	0.0052	0.086	0.086
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0048	0.076	0.1784
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0018	0.015	0.024
Trypanosoma brucei	protein kinase, putative	0.0051	0.0829	0.1958
Onchocerca volvulus		0.0026	0.0313	0.0348
Giardia lamblia	Encystation-specific protease	0.0041	0.0624	0.0767
Schistosoma mansoni	lamin	0.0026	0.0313	0.0313
Trypanosoma cruzi	cysteine peptidase, putative	0.0205	0.401	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0018	0.015	0.024
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0041	0.0624	0.1438
Brugia malayi	calpain 7	0.006	0.1024	0.1307
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0069	0.1207	0.1207
Giardia lamblia	Cathepsin L precursor	0.0041	0.0624	0.0767
Trypanosoma cruzi	prolyl endopeptidase	0.0129	0.2452	0.6061
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0244	0.0479
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0313	0.0313
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0278	0.0564
Entamoeba histolytica	cysteine proteinase 1, putative	0.0107	0.1997	0.4909
Schistosoma mansoni	hypothetical protein	0.0372	0.7473	0.7473
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0728	0.0728
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	0.3317	0.3317
Schistosoma mansoni	cathepsin C	0.0041	0.0624	0.0624
Onchocerca volvulus		0.0205	0.401	0.5332
Brugia malayi	prolyl oligopeptidase family protein	0.0129	0.2452	0.3232
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0018	0.015	0.024
Trypanosoma brucei	hypothetical protein	0.0018	0.015	0.024
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0624	0.1082
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0624	0.0624
Echinococcus granulosus	peroxidasin	0.0103	0.1917	0.1917
Mycobacterium tuberculosis	Hypothetical protein	0.0372	0.7473	1
Loa Loa (eye worm)	calpain 5	0.0042	0.0648	0.1127
Brugia malayi	calpain family protein 1	0.016	0.3089	0.409
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.006	0.1024	0.2451
Giardia lamblia	Cathepsin L precursor	0.0041	0.0624	0.0767
Mycobacterium tuberculosis	Probable peptidase	0.0051	0.0839	0.0823
Echinococcus granulosus	acylamino acid releasing enzyme	0.0014	0.0055	0.0055
Giardia lamblia	Cathepsin L-like protease	0.0041	0.0624	0.0767
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0041	0.0624	0.1082
Schistosoma mansoni	cathepsin B (C01 family)	0.0041	0.0624	0.0624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.006	0.1024	0.2451
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0829	0.1958
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0018	0.015	0.024
Loa Loa (eye worm)	calpain	0.006	0.1024	0.1805
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0089	0.0047
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0624	0.1438
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0041	0.0624	0.1438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0041	0.0624	0.0767
Plasmodium vivax	vivapain-2	0.0205	0.401	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0041	0.0624	0.0767
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0624	0.1438
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0069	0.1207	0.2912
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0089	0.0089
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0052	0.086	0.1085
Leishmania major	cathepsin L-like protease	0.0205	0.401	1
Brugia malayi	Cathepsin L-like precursor	0.0138	0.2637	0.3481
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0624	0.0767
Giardia lamblia	Hypothetical protein	0.0372	0.7473	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Mycobacterium tuberculosis	Long conserved protein	0.0372	0.7473	1
Schistosoma mansoni	hypothetical protein	0.0329	0.6576	0.6576
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0492	0.0844
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0624	0.0624
Loa Loa (eye worm)	ctsf protein	0.0205	0.401	0.7195
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.006	0.1024	0.2451
Brugia malayi	Papain family cysteine protease containing protein	0.0205	0.401	0.5332
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0829	0.1044
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0018	0.015	0.024
Loa Loa (eye worm)	hypothetical protein	0.0052	0.086	0.1508
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Onchocerca volvulus		0.0138	0.2637	0.3481
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0014	0.0055	0.0055
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0089	0.0047
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0069	0.1207	0.2134
Brugia malayi	Papain family cysteine protease containing protein	0.0041	0.0624	0.0767
Echinococcus granulosus	geminin	0.0329	0.6576	0.6576
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0372	0.7473	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0041	0.0624	0.1438
Leishmania major	hypothetical protein, unknown function	0.0018	0.015	0.024
Giardia lamblia	Cysteine protease	0.0041	0.0624	0.0767
Echinococcus granulosus	lamin dm0	0.0026	0.0313	0.0313
Mycobacterium leprae	Conserved hypothetical protein	0.0372	0.7473	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0048	0.076	0.1784
Leishmania major	hypothetical protein, conserved	0.0024	0.0278	0.0564
Trichomonas vaginalis	calpain, putative	0.0018	0.015	0.0128
Brugia malayi	hypothetical protein	0.0024	0.0278	0.0301
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0129	0.2452	0.2452
Schistosoma mansoni	cathepsin S (C01 family)	0.0041	0.0624	0.0624
Onchocerca volvulus		0.0205	0.401	0.5332
Onchocerca volvulus		0.0205	0.401	0.5332
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0041	0.0624	0.1438
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0107	0.1997	0.1997
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0138	0.2637	0.3481
Entamoeba histolytica	cysteine proteinase, putative	0.0107	0.1997	0.4909
Trichomonas vaginalis	peptide N-glycanase, putative	0.0372	0.7473	1
Trypanosoma brucei	calpain, putative	0.0018	0.015	0.024
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0278	0.0564
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0041	0.0624	0.0767
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0244	0.0479
Echinococcus granulosus	cathepsin L cysteine protease	0.0107	0.1997	0.1997
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0081	0.1457	0.3544
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0205	0.401	0.401
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0244	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0051	0.0839	0.0823
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0041	0.0624	0.0767
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0048	0.076	0.076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0624	0.1438
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0041	0.0624	0.0624
Loa Loa (eye worm)	prolyl oligopeptidase	0.0014	0.0055	0.0055
Leishmania major	calpain family cysteine protease-like protein	0.0018	0.015	0.024
Loa Loa (eye worm)	MBCTL1	0.0052	0.086	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0089	0.0117
Onchocerca volvulus	Cathepsin L homolog	0.0205	0.401	0.5332
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0829	0.0829
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0205	0.401	0.7195
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Brugia malayi	MAP kinase sur-1	0.0051	0.0829	0.1044
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0048	0.076	0.076
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2637	0.4717
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0069	0.1207	0.1207
Schistosoma mansoni	hypothetical protein	0.0285	0.5668	0.5668
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0313	0.0348
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0829	0.1044
Echinococcus multilocularis	cathepsin b	0.0171	0.3317	0.3317
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0278	0.0458
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0829	0.1958
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0089	0.0117
Loa Loa (eye worm)	calpain family protein 1	0.0118	0.2214	0.3953
Echinococcus multilocularis	calpain	0.006	0.1024	0.1024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3317	0.3317
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0244	0.0479
Entamoeba histolytica	cysteine proteinase, putative	0.0138	0.2637	0.6529
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0041	0.0624	0.1438
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0048	0.076	0.1784
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0052	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	0.1997	0.4909
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0051	0.0839	0.0823
Echinococcus granulosus	cpg binding protein	0.0037	0.0533	0.0533
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0018	0.015	0.0128
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0089
Brugia malayi	Animal haem peroxidase family protein	0.0103	0.1917	0.251
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0014	0.0055	0.0055
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0313	0.0522
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0116	0.2171	0.2666
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0048	0.076	0.0951
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0048	0.076	0.1784
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.006	0.1024	0.2451
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2713	0.4853
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0107	0.1997	0.2618
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0107	0.1997	0.4909
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0244	0.0479
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0829	0.1958
Trypanosoma cruzi	cysteine proteinase, putative	0.0107	0.1997	0.4909
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0244	0.0255
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0041	0.0624	0.0767
Trypanosoma cruzi	conserved protein	0.0018	0.015	0.024
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0041	0.0624	0.1082
Giardia lamblia	Cathepsin B precursor	0.0041	0.0624	0.0767
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0689	0.0689
Brugia malayi	Animal haem peroxidase family protein	0.0103	0.1917	0.251
Plasmodium falciparum	serine repeat antigen 2	0.0041	0.0624	0.1438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0014	0.0055	0.0055
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0041	0.0624	0.0767
Entamoeba histolytica	cysteine proteinase, putative	0.0107	0.1997	0.4909
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0041	0.0624	0.1438
Brugia malayi	Cathepsin L-like precursor	0.0205	0.401	0.5332
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2637	0.4717
Leishmania major	cathepsin L-like protease	0.0205	0.401	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Loa Loa (eye worm)	hypothetical protein	0.0205	0.401	0.7195
Toxoplasma gondii	cathepsin B	0.0081	0.1457	0.3544
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0624	0.1438
Echinococcus granulosus	cathepsin b	0.0171	0.3317	0.3317
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0041	0.0624	0.0767
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0205	0.401	0.7195
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1147	0.2026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0048	0.076	0.076
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0051	0.0839	0.1983
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0205	0.401	0.401
Onchocerca volvulus		0.0205	0.401	0.5332
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.006	0.1024	0.2451
Echinococcus granulosus	Transglutaminase	0.0372	0.7473	0.7473
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0089	0.0089
Trypanosoma brucei	calpain-like protein, putative	0.006	0.1024	0.2451
Leishmania major	cysteine peptidase A (CPA)	0.0205	0.401	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0103	0.1917	0.251
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0066	0.1147	0.2026
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0018	0.015	0.024
Leishmania major	calpain protease-like protein	0.0018	0.015	0.024
Loa Loa (eye worm)	prolyl oligopeptidase	0.0014	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.016	0.3089	0.5532
Trypanosoma cruzi	kinesin, putative	0.0042	0.0648	0.1501
Trypanosoma brucei	calpain-like protein, putative	0.006	0.1024	0.2451
Onchocerca volvulus	Peroxidase homolog	0.0103	0.1917	0.251
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Trypanosoma cruzi	kinesin, putative	0.0042	0.0648	0.1501
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0107	0.1997	0.2618
Trypanosoma brucei	prolyl endopeptidase	0.0129	0.2452	0.6061
Schistosoma mansoni	cathepsin s	0.0066	0.1147	0.1147
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0041	0.0624	0.0624
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Entamoeba histolytica	cysteine proteinase 2	0.0107	0.1997	0.4909
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0018	0.015	0.024
Echinococcus multilocularis	cathepsin L cysteine protease	0.0205	0.401	0.401
Echinococcus multilocularis	cathepsin L	0.0041	0.0624	0.0624
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0689	0.0689
Giardia lamblia	Cathepsin B precursor	0.0041	0.0624	0.0767
Echinococcus multilocularis	lamin dm0	0.0026	0.0313	0.0313
Toxoplasma gondii	exonuclease III APE	0.0023	0.0244	0.0479
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0829	0.1958
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0052	0.086	0.086
Onchocerca volvulus		0.01	0.1838	0.2404
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0041	0.0624	0.0767
Plasmodium falciparum	serine repeat antigen 5	0.0041	0.0624	0.1438
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma cruzi	oligopeptidase b	0.0051	0.0839	0.1983
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0052	0.086	0.086
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0018	0.015	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0055	0.0055
Brugia malayi	Papain family cysteine protease containing protein	0.0041	0.0624	0.0767
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Brugia malayi	Papain family cysteine protease containing protein	0.0041	0.0624	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0624	0.1082
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0069	0.1207	0.1553
Giardia lamblia	Cathepsin B precursor	0.0041	0.0624	0.0767
Echinococcus multilocularis	calpain family protein 1, d	0.0118	0.2214	0.2214
Echinococcus multilocularis	cathepsin L	0.0107	0.1997	0.1997
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0041	0.0624	0.0767
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0041	0.0624	0.0624
Loa Loa (eye worm)	calpain D	0.0018	0.015	0.0227
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0829	0.1044
Giardia lamblia	Cathepsin B precursor	0.0041	0.0624	0.0767
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0014	0.0055	0.0055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0313	0.0522
Toxoplasma gondii	proteasome subunit beta type, putative	0.0069	0.1207	0.2912
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0829	0.1044
Echinococcus multilocularis	hypothetical protein	0.006	0.1024	0.1024
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	0.3317	0.8247
Toxoplasma gondii	cathepsin CPC2	0.0041	0.0624	0.1438
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0018	0.015	0.024
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Onchocerca volvulus		0.0103	0.1917	0.251
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0041	0.0624	0.1438
Echinococcus granulosus	cathepsin L	0.0041	0.0624	0.0624
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.1134	0.2729
Onchocerca volvulus	Dual oxidase homolog	0.0103	0.1917	0.251
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0278	0.0564
Schistosoma mansoni	ap endonuclease	0.0023	0.0244	0.0244
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0018	0.015	0.024
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0055	0.0055
Echinococcus granulosus	intermediate filament protein	0.0026	0.0313	0.0313
Echinococcus multilocularis	dnaJ subfamily B	0.0494	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0624	0.0767
Brugia malayi	mbt repeat family protein	0.0046	0.0728	0.0907
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.1297	0.1297
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0624	0.1082
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0689	0.0689
Echinococcus multilocularis	cysteine protease	0.0205	0.401	0.401
Trypanosoma cruzi	cysteine protease, putative	0.0107	0.1997	0.4909
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0069	0.1207	0.2912
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0728	0.0728
Brugia malayi	cathepsin L-like precursor	0.0138	0.2637	0.3481
Schistosoma mansoni	Mername-AA248 (C02 family)	0.006	0.1024	0.1024
Plasmodium falciparum	serine repeat antigen 7	0.0041	0.0624	0.1438
Brugia malayi	Animal haem peroxidase family protein	0.0103	0.1917	0.251
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0244	0.0255
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0041	0.0624	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0624	0.1082
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0728	0.0728
Giardia lamblia	Cathepsin B precursor	0.0081	0.1457	0.189
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0041	0.0624	0.0767
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0829	0.0829
Brugia malayi	Papain family cysteine protease containing protein	0.0107	0.1997	0.2618
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Schistosoma mansoni	cathepsin F (C01 family)	0.0205	0.401	0.401
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0829	0.0829
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0129	0.2452	0.3232
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0089	0.0089
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0278	0.0564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0107	0.1997	0.4909
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0138	0.2637	0.6529
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0244	0.5
Leishmania major	cathepsin L-like protease	0.0205	0.401	1
Leishmania major	oligopeptidase b	0.0051	0.0839	0.1983
Loa Loa (eye worm)	animal heme peroxidase	0.0103	0.1917	0.3416
Brugia malayi	mbt repeat family protein	0.0046	0.0728	0.0907
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0041	0.0624	0.0767
Toxoplasma gondii	hypothetical protein	0.0018	0.015	0.024
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0829	0.1044
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0014	0.0055	0.0055
Schistosoma mansoni	hypothetical protein	0.0329	0.6576	0.6576
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3317	0.5943
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0048	0.076	0.076
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.3628	0.3628
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0052	0.086	0.086
Leishmania major	proteasome beta 5 subunit, putative	0.0069	0.1207	0.2912
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0829	0.1958
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Mycobacterium ulcerans	hypothetical protein	0.0372	0.7473	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0041	0.0624	0.0767
Echinococcus multilocularis	Transglutaminase	0.0372	0.7473	0.7473
Plasmodium vivax	unspecified product	0.0041	0.0624	0.1438
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0167	0.3239	0.3239
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0069	0.1207	0.1332
Giardia lamblia	Cathepsin L precursor	0.0041	0.0624	0.0767
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Echinococcus multilocularis	lamin	0.0026	0.0313	0.0313
Brugia malayi	Animal haem peroxidase family protein	0.0103	0.1917	0.251
Onchocerca volvulus	Cathepsin F homolog	0.0205	0.401	0.5332
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.076	0.0951
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0244	0.0255
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0041	0.0624	0.1438
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0129	0.2452	0.2452
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Plasmodium falciparum	serine repeat antigen 8	0.0041	0.0624	0.1438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Brugia malayi	calpain family protein 1	0.016	0.3089	0.409
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0728	0.0728
Onchocerca volvulus		0.0205	0.401	0.5332
Loa Loa (eye worm)	hypothetical protein	0.0018	0.015	0.0227
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0278	0.0564
Loa Loa (eye worm)	blistered cuticle protein 3	0.0103	0.1917	0.3416
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0089
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0048	0.076	0.1784
Brugia malayi	Papain family cysteine protease containing protein	0.0107	0.1997	0.2618
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0107	0.1997	0.1997
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.1147	0.2761
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma cruzi	cysteine peptidase, putative	0.0107	0.1997	0.4909
Giardia lamblia	Cysteine protease	0.0041	0.0624	0.0767
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3317	0.3317
Schistosoma mansoni	cpg binding protein	0.0035	0.0492	0.0492
Mycobacterium ulcerans	hypothetical protein	0.0372	0.7473	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.006	0.1024	0.2451
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.1024	0.2451
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0048	0.076	0.0951
Leishmania major	kinesin, putative	0.0042	0.0648	0.1501
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0829	0.1958
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0042	0.0648	0.1501
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0205	0.401	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1147	0.2026
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0018	0.015	0.0128
Brugia malayi	Cathepsin L-like precursor	0.0066	0.1147	0.1472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0771	0.0965
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0728	0.0907
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0278	0.0564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Schistosoma mansoni	hypothetical protein	0.0494	1	1
Entamoeba histolytica	protein kinase, putative	0.0043	0.0658	0.1525
Brugia malayi	Cathepsin L-like precursor	0.0205	0.401	0.5332
Giardia lamblia	Cathepsin B precursor	0.0081	0.1457	0.189
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0014	0.0055	0.0055
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0829	0.0829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0138	0.2637	0.3481
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0205	0.401	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Echinococcus granulosus	calpain	0.006	0.1024	0.1024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Onchocerca volvulus	Peroxidasin homolog	0.0103	0.1917	0.251
Echinococcus multilocularis	cpg binding protein	0.0037	0.0533	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0018
Echinococcus multilocularis	cysteine protease	0.0205	0.401	0.401
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0689	0.0689
Giardia lamblia	Cysteine protease	0.0041	0.0624	0.0767
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.015	0.0128
Plasmodium vivax	calpain, putative	0.006	0.1024	0.2451
Onchocerca volvulus	Cathepsin L homolog	0.0041	0.0624	0.0767
Loa Loa (eye worm)	animal heme peroxidase	0.0103	0.1917	0.3416
Giardia lamblia	Cathepsin L-like protease	0.0041	0.0624	0.0767
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0728	0.127
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0051	0.0839	0.1983
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0624	0.0767
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.1147	0.2761
Brugia malayi	intermediate filament protein	0.0026	0.0313	0.0348
Trypanosoma brucei	antigen, putative	0.006	0.1024	0.2451
Brugia malayi	Blistered cuticle protein 3	0.0103	0.1917	0.251
Trypanosoma cruzi	cysteine proteinase, putative	0.0107	0.1997	0.4909
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0829	0.1958
Giardia lamblia	Cathepsin B precursor	0.0041	0.0624	0.0767
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0107	0.1997	0.1997
Brugia malayi	calpain 5	0.0042	0.0648	0.08
Echinococcus multilocularis	prolyl endopeptidase	0.0129	0.2452	0.2452
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0624	0.0624
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.006	0.1024	0.2451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Toxoplasma gondii	cathepsin CPL	0.0205	0.401	1
Onchocerca volvulus		0.0205	0.401	0.5332
Onchocerca volvulus		0.0103	0.1917	0.251
Giardia lamblia	Cathepsin L precursor	0.0041	0.0624	0.0767
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0624	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0455	0.0778
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0771	0.1348
Entamoeba histolytica	cysteine proteinase, putative	0.0107	0.1997	0.4909
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0069	0.1207	0.2912
Brugia malayi	hypothetical protein	0.0016	0.0099	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Giardia lamblia	Cysteine protease	0.0041	0.0624	0.0767
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.028	0.5564	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0624	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Echinococcus granulosus	calpain 7 C02 family	0.006	0.1024	0.1024
Brugia malayi	calpain D	0.0018	0.015	0.0128
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0063	0.0011
Entamoeba histolytica	cysteine protease, putative	0.0107	0.1997	0.4909
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0624	0.0767
Trypanosoma cruzi	cruzipain precursor, putative	0.0205	0.401	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0829	0.1958
Brugia malayi	Cathepsin L-like precursor	0.0205	0.401	0.5332
Brugia malayi	Cathepsin L-like precursor	0.0205	0.401	0.5332
Schistosoma mansoni	calpain (C02 family)	0.006	0.1024	0.1024
Leishmania major	cathepsin L-like protease	0.0205	0.401	1
Echinococcus granulosus	calpain A	0.0167	0.3239	0.3239
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Brugia malayi	cathepsin F-like cysteine proteinase	0.0041	0.0624	0.0767
Entamoeba histolytica	cysteine proteinase, putative	0.0107	0.1997	0.4909
Plasmodium falciparum	serine repeat antigen 6	0.0041	0.0624	0.1438
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0069	0.1207	0.1553
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0041	0.0624	0.1438
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0041	0.0624	0.0767
Brugia malayi	follicle stimulating hormone receptor	0.028	0.5564	0.7427
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.1024	0.2451
Onchocerca volvulus	Peroxidasin homolog	0.0103	0.1917	0.251
Brugia malayi	calpain 5	0.0018	0.015	0.0128
Loa Loa (eye worm)	cathepsin B	0.0081	0.1457	0.2585
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0689	0.0855
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0041	0.0624	0.1438
Trypanosoma brucei	Calpain-like protein 1.2	0.0018	0.015	0.024
Plasmodium vivax	serine-repeat antigen (SERA)	0.0041	0.0624	0.1438
Brugia malayi	Cathepsin L-like precursor	0.0205	0.401	0.5332
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0728	0.0728
Schistosoma mansoni	hypothetical protein	0.0018	0.015	0.015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0063	0.007
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0372	0.7473	1
Echinococcus granulosus	cathepsin L	0.0107	0.1997	0.1997
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0728	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0728	0.127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0205	0.401	0.5332
Onchocerca volvulus		0.0035	0.0492	0.0589
Echinococcus granulosus	cathepsin b	0.0171	0.3317	0.3317
Schistosoma mansoni	calpain-7 (C02 family)	0.0067	0.1161	0.1161
Trypanosoma cruzi	major cysteine proteinase, putative	0.0041	0.0624	0.1438
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0829	0.0829
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0689	0.0689
Toxoplasma gondii	cathepsin CPC1	0.0041	0.0624	0.1438
Giardia lamblia	Hypothetical protein	0.0041	0.0624	0.0767
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0492	0.0589
Schistosoma mansoni	hypothetical protein	0.0033	0.0455	0.0455
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0081	0.1457	0.3544
Echinococcus multilocularis	cathepsin L cysteine protease	0.0205	0.401	0.401
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0041	0.0624	0.0767
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0138	0.2637	0.3481
Plasmodium falciparum	serine repeat antigen 9	0.0041	0.0624	0.1438
Plasmodium falciparum	proteasome subunit beta type-5	0.0069	0.1207	0.2912
Giardia lamblia	Cathepsin L precursor	0.0041	0.0624	0.0767
Schistosoma mansoni	calpain-2 (C02 family)	0.0018	0.015	0.015
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Echinococcus multilocularis	cathepsin b	0.0171	0.3317	0.3317
Mycobacterium ulcerans	proteasome PrcB	0.0069	0.1207	0.1332
Onchocerca volvulus		0.0103	0.1917	0.251
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0041	0.0624	0.0767
Trichomonas vaginalis	hypothetical protein	0.0018	0.015	0.0128
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0018	0.015	0.024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Onchocerca volvulus		0.0205	0.401	0.5332
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Brugia malayi	cathepsin F-like cysteine proteinase	0.0066	0.1147	0.1472
Loa Loa (eye worm)	animal heme peroxidase	0.0103	0.1917	0.3416
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0041	0.0624	0.0767
Loa Loa (eye worm)	calpain family protein 1	0.016	0.3089	0.5532
Trypanosoma brucei	kinesin, putative	0.0042	0.0648	0.1501
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0167	0.3239	0.3239
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0048	0.076	0.076
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0041	0.0624	0.1438
Trichomonas vaginalis	calpain, putative	0.0018	0.015	0.0128
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0069	0.1207	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1147	0.2026
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0244	0.0397
Echinococcus multilocularis	calpain A	0.0167	0.3239	0.3239
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.3628	0.3628
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0728	0.0728
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.006	0.1024	0.2451
Schistosoma mansoni	ap endonuclease	0.0023	0.0244	0.0244
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0066	0.1147	0.1472
Echinococcus granulosus	GPCR family 2	0.0015	0.0089	0.0089
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0069	0.1207	0.2912
Trypanosoma cruzi	major cysteine proteinase, putative	0.0041	0.0624	0.1438
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0041	0.0624	0.1438
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0278	0.0564
Echinococcus multilocularis	calpain 5	0.006	0.1024	0.1024
Onchocerca volvulus		0.0046	0.0728	0.0907
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0089
Giardia lamblia	Hypothetical protein	0.0041	0.0624	0.0767
Echinococcus multilocularis	peroxidasin	0.0103	0.1917	0.1917
Giardia lamblia	Cathepsin B precursor	0.0081	0.1457	0.189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Onchocerca volvulus		0.0026	0.0313	0.0348
Echinococcus granulosus	cysteine protease	0.0107	0.1997	0.1997
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0118	0.2214	0.3953
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0048	0.076	0.076
Brugia malayi	cathepsin B-like cysteine proteinase	0.0171	0.3317	0.4397
Entamoeba histolytica	cysteine proteinase, putative	0.0205	0.401	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0205	0.401	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Trypanosoma brucei	Calpain-like protein 2	0.0018	0.015	0.024
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0244	0.0479
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0048	0.076	0.0951
Schistosoma mansoni	cpg binding protein	0.0037	0.0533	0.0533
Schistosoma mansoni	cathepsin F (C01 family)	0.0205	0.401	0.401
Brugia malayi	fibroinase precursor	0.0041	0.0624	0.0767
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0167	0.3239	0.3239
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0205	0.401	0.5332
Schistosoma mansoni	lamin	0.0026	0.0313	0.0313
Echinococcus granulosus	ubiquitin specific protease 41	0.0048	0.076	0.076
Schistosoma mansoni	cathepsin F (C01 family)	0.0138	0.2637	0.2637
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0051	0.0839	0.1983
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0051	0.0839	0.1983
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0455	0.054
Brugia malayi	Cathepsin L-like precursor	0.0138	0.2637	0.3481
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0041	0.0624	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1917	0.3416
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0018	0.015	0.024
Brugia malayi	Thioredoxin family protein	0.0372	0.7473	1
Plasmodium falciparum	calpain	0.0018	0.015	0.024
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0014	0.0055	0.0055
Trypanosoma cruzi	oligopeptidase b	0.0051	0.0839	0.1983
Loa Loa (eye worm)	animal heme peroxidase	0.0103	0.1917	0.3416
Loa Loa (eye worm)	fibroinase	0.0205	0.401	0.7195
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0205	0.401	1
Giardia lamblia	Transglutaminase/protease, putative	0.0372	0.7473	1
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0129	0.2452	0.6061
Loa Loa (eye worm)	hypothetical protein	0.0129	0.2452	0.4382
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0041	0.0624	0.1438
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0018	0.015	0.024
Schistosoma mansoni	cpg binding protein	0.0037	0.0533	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0624	0.1082
Leishmania major	cathepsin L-like protease	0.0205	0.401	1
Entamoeba histolytica	cysteine proteinase, putative	0.0205	0.401	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.1838	0.3275
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0624	0.0624
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0081	0.1457	0.1457
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0081	0.1457	0.3544
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.006	0.1024	0.2451
Echinococcus multilocularis	musashi	0.0026	0.0313	0.0313
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.016	0.3089	0.3089
Toxoplasma gondii	prolyl endopeptidase	0.0129	0.2452	0.6061
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Plasmodium vivax	vivapain-3	0.0107	0.1997	0.4909
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0624	0.1438
Plasmodium vivax	unspecified product	0.0107	0.1997	0.4909
Mycobacterium ulcerans	putative transglutaminase-like protein	0.0372	0.7473	1
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0069	0.1207	0.2912
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2637	0.4717
Leishmania major	cathepsin L-like protease	0.0205	0.401	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3317	0.3317
Echinococcus granulosus	cathepsin l1	0.0138	0.2637	0.2637
Echinococcus granulosus	prolyl endopeptidase	0.0129	0.2452	0.2452
Schistosoma mansoni	peroxidasin	0.0103	0.1917	0.1917
Echinococcus granulosus	calpain A	0.006	0.1024	0.1024
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0689	0.0689
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0771	0.0965
Trypanosoma brucei	calpain-like protein, putative	0.006	0.1024	0.2451
Trypanosoma cruzi	cysteine peptidase, putative	0.0205	0.401	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0205	0.401	0.5332
Plasmodium vivax	unspecified product	0.0066	0.1147	0.2761
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0624	0.0767
Brugia malayi	Animal haem peroxidase family protein	0.0103	0.1917	0.251
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0018	0.015	0.0128
Echinococcus granulosus	cathepsin l1	0.0205	0.401	0.401
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0089
Leishmania major	cathepsin L-like protease	0.0205	0.401	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.401	0.5332
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0624	0.0767
Giardia lamblia	Cathepsin L precursor	0.0041	0.0624	0.0767
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0048	0.076	0.0951
Entamoeba histolytica	hypothetical protein	0.0041	0.0624	0.1438
Echinococcus multilocularis	calpain 7 (C02 family)	0.006	0.1024	0.1024
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0041	0.0624	0.0767
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0048	0.076	0.076
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0018	0.015	0.024

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 10 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1552272

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1411775