Detailed information for compound 1429980

Basic information

Technical information
  • TDR Targets ID: 1429980
  • Name: 3-fluoro-N-[(8-methylimidazo[1,2-a]pyridin-2- yl)methyl]benzenesulfonamide
  • MW: 319.354 | Formula: C15H14FN3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)S(=O)(=O)NCc1cn2c(n1)c(C)ccc2
  • InChi: 1S/C15H14FN3O2S/c1-11-4-3-7-19-10-13(18-15(11)19)9-17-22(20,21)14-6-2-5-12(16)8-14/h2-8,10,17H,9H2,1H3
  • InChiKey: ZKUPUVUNCVRGCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-fluoro-N-[(8-methyl-2-imidazo[1,2-a]pyridinyl)methyl]benzenesulfonamide
  • SMR000127240
  • MLS000529677
  • ChemDiv3_011792

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0184 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0184 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0237 0.0225
Brugia malayi hypothetical protein 0.0006 0.0039 0.0044
Loa Loa (eye worm) CYP4Cod1 0.004 0.0893 0.1002
Schistosoma mansoni hypothetical protein 0.0058 0.1342 0.1342
Leishmania major eukaryotic initiation factor 4a, putative 0.0359 0.8911 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0006 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0286 0.706 0.7922
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0426 0.0097
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0097 0.0097
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0022 0.0025
Onchocerca volvulus 0.0014 0.0237 0.0266
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0426 0.0217
Echinococcus granulosus RUN 0.0019 0.0365 0.0365
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0426 0.1487
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0207
Brugia malayi steroid hormone receptor 0.0012 0.0184 0.0207
Schistosoma mansoni ap endonuclease 0.0019 0.0343 0.0343
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0022 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0184 0.0207
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0359 0.8911 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0207
Mycobacterium leprae putative cytochrome p450 0.0022 0.0426 1
Onchocerca volvulus 0.0028 0.0588 0.066
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0426 0.1487
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0184 0.0184
Leishmania major protein kinase, putative 0.0015 0.025 0.0014
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0426 0.0097
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0038 0.0000000045361
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0184 0.0184
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0184 0.0184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045361
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0184 0.0184
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0426 0.0217
Schistosoma mansoni rab6-interacting 0.0019 0.0365 0.0365
Schistosoma mansoni ap endonuclease 0.0019 0.0343 0.0343
Schistosoma mansoni cytochrome P450 0.0022 0.0426 0.0426
Brugia malayi cytochrome P450 0.0022 0.0426 0.0478
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.121 0.1122
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0237 0.0266
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0426 1
Echinococcus multilocularis dnaJ subfamily B 0.0402 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1266 0.1266
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0237 0.5
Brugia malayi PAS domain containing protein 0.0055 0.1264 0.1418
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0184 0.0207
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0365 0.0026
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0207
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0184 0.0207
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0237 0.0225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1385 0.1385
Schistosoma mansoni loxhd1 0.0019 0.0365 0.0365
Schistosoma mansoni rab6-interacting 0.0019 0.0365 0.0365
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0426 0.1487
Schistosoma mansoni nuclear receptor 0.0006 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0426 0.0097
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045361
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0038 0.0000000045361
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0359 0.8911 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0426 0.1487
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.1897 0.2129
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0359 0.8911 0.8911
Plasmodium falciparum eukaryotic initiation factor 4A 0.0359 0.8911 1
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0903 0.1014
Leishmania major cytochrome p450-like protein 0.004 0.0893 0.0755
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.025 0.0014
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0365 0.0365
Schistosoma mansoni cpg binding protein 0.003 0.0628 0.0628
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0365 0.0365
Trypanosoma brucei protein kinase, putative 0.0053 0.121 0.1013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0184 0.0207
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.121 0.1321
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0426 0.0097
Schistosoma mansoni survival motor neuron protein 0.0058 0.1342 0.1342
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.121 0.121
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0365 0.0365
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0184 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0237 0.0225
Onchocerca volvulus 0.0019 0.0365 0.041
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0359 0.8911 0.8911
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.121 0.1013
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0893 0.1002
Onchocerca volvulus 0.0006 0.0022 0.0025
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0426 0.0097
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0184 0.0207
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0237 0.0225
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0184 0.0184
Brugia malayi tailless protein 0.0006 0.0022 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0343 0.0384
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0184 0.0184
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0343 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0184 0.0184
Onchocerca volvulus 0.0019 0.0365 0.041
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0426 0.1487
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0426 0.1487
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0426 0.0097
Brugia malayi CXXC zinc finger family protein 0.0028 0.0588 0.066
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.121 0.1013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0365 0.041
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0022 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0184 0.0184
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0022 0.0025
Brugia malayi nuclear receptor NHR-67 0.0006 0.0022 0.0025
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0426 0.1487
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0359 0.8911 0.8911
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0426 0.1487
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0365 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1266 0.1266
Schistosoma mansoni lipoxygenase 0.0054 0.1243 0.1243
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0426 0.0097
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0359 0.8911 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0022 0.0025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0588 0.066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1266 0.1266
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0022 0.0022
Brugia malayi nuclear hormone receptor 0.0006 0.0022 0.0025
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0359 0.8911 1
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0893 0.0755
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0207
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0184 0.0207
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0359 0.8911 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0184 0.0184
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0365 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0184 0.0207
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0006 0.0022 0.0022
Brugia malayi hypothetical protein 0.0019 0.0365 0.041
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0237 0.0225
Brugia malayi nuclear hormone receptor 0.0012 0.0184 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0184 0.0207
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.121 0.1122
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0184 0.0207
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.025 0.0014
Schistosoma mansoni polycystin 1-related 0.0019 0.0365 0.0365
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.121 0.1358
Schistosoma mansoni hypothetical protein 0.0402 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1266 0.1266
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0044
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.025 0.0014
Echinococcus granulosus thyroid hormone receptor alpha 0.0006 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0893 0.9806
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0022 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.121 0.1321
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0893 0.1002
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0426 0.1487
Brugia malayi Cytochrome P450 family protein 0.004 0.0893 0.1002
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0426 0.0097
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0426 0.1487
Loa Loa (eye worm) hypothetical protein 0.0014 0.0237 0.0266
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.121 0.121
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0022 0.0022
Schistosoma mansoni zinc finger protein 0.0006 0.0022 0.0022
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1342 0.1506
Loa Loa (eye worm) pax transcription factor protein 2 0.0255 0.6293 0.7062
Treponema pallidum ATP-dependent RNA helicase 0.0359 0.8911 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1266 0.1266
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045361
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0184 0.0207
Loa Loa (eye worm) hypoxia-induced factor 1 0.0171 0.4169 0.4678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0184 0.0207
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0054 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0039 0.0044
Brugia malayi Pax transcription factor protein 2 0.0255 0.6293 0.7062
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0359 0.8911 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.025 0.0014
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0184 0.0184
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0039 0.0044
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0184 0.0207
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0184 0.0207
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1243 0.1243
Trypanosoma brucei cytochrome P450, putative 0.004 0.0893 0.0642
Leishmania major protein kinase, putative 0.0015 0.025 0.0014
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0022 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0022 0.0022
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0237 0.0225
Brugia malayi Cytochrome P450 family protein 0.004 0.0893 0.1002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0184 0.0207
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0237 0.0237
Brugia malayi nuclear receptor RXR 0.0006 0.0039 0.0044
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0022 0.0022
Loa Loa (eye worm) DR-78 0.0006 0.0022 0.0025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0044
Brugia malayi hypothetical protein 0.0006 0.0039 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0426 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0365 0.041
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0039 0.0039
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0006 0.0022 0.0022
Brugia malayi nuclear receptor RXR 0.0006 0.0022 0.0025
Brugia malayi Cytochrome P450 family protein 0.008 0.1897 0.2129
Plasmodium vivax RNA helicase-1, putative 0.0359 0.8911 1
Schistosoma mansoni cpg binding protein 0.003 0.0628 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0184 0.0207
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1224 0.1028
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0184 0.0184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045361
Brugia malayi Doublecortin family protein 0.0019 0.0365 0.041
Leishmania major cytochrome p450-like protein 0.0022 0.0426 0.0217
Echinococcus granulosus eukaryotic initiation factor 4A 0.0359 0.8911 0.8911
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0237 0.0225
Brugia malayi eukaryotic initiation factor 4A 0.0359 0.8911 1
Schistosoma mansoni hypothetical protein 0.0022 0.0426 0.0426
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0184 0.0207
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0426 0.1487
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0237 0.0225
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.121 0.1122
Brugia malayi hypothetical protein 0.0185 0.4529 0.5083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0426 0.0097
Echinococcus multilocularis 0.0022 0.0426 0.0426
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1243 0.1243
Loa Loa (eye worm) hypothetical protein 0.0359 0.8911 1
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0022 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0426 0.0097
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0022 0.0025
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0426 0.1487
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0359 0.8911 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0237 0.0237
Echinococcus granulosus nuclear receptor nhr 48 0.0006 0.0022 0.0022
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0237 0.0237
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045361
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0359 0.8911 0.8911
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0097 0.0109
Brugia malayi Cytochrome P450 family protein 0.0022 0.0426 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0184 0.0207
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0184 0.0184
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0343 0.0343
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0237 0.0237
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0039 0.0039
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.121 0.1013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0237 0.0225
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0426 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0038 0.0000000045361
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0893 0.0755
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0426 0.0097
Loa Loa (eye worm) hypothetical protein 0.0006 0.0039 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1266 0.1421
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0426 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0184 0.0207
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.1264 0.1264
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0426 0.0217
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.706 0.706
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1266 0.1266
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0184 0.0207
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0022 0.0022
Brugia malayi nuclear receptor NHR-88 0.0012 0.0184 0.0207
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0359 0.8911 0.8911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0184 0.0207
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0184 0.0184
Onchocerca volvulus 0.0012 0.0184 0.0207
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.706 0.706
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.121 0.1122
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0426 0.0097
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0426 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.121 0.1321
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.121 0.1122
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0426 0.0097
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0359 0.8911 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0184 0.0184
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0237 0.0225
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0426 0.1487
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0022 0.0025
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0426 0.1487
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0039 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0184 0.0184
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0184 0.0184
Brugia malayi conserved hypotetical protein 0.0006 0.0022 0.0025
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.121 0.121
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0343 0.0343
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0343 0.0384
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0426 0.1487
Schistosoma mansoni coup transcription factor 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0426 0.0097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0207
Echinococcus multilocularis RUN 0.0019 0.0365 0.0365
Schistosoma mansoni nuclear receptor 0.0006 0.0022 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0094 0.0106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0343 0.0121
Schistosoma mansoni lipoxygenase 0.0019 0.0365 0.0365
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0426 0.0097
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0097 0.0097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Brugia malayi ecdysteroid receptor 0.0012 0.0184 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0184 0.0207
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0184 0.0207
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0054 0.0054
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0903 0.0903
Onchocerca volvulus 0.0041 0.0903 0.1014
Onchocerca volvulus 0.0058 0.1342 0.1506
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Brugia malayi hypothetical protein 0.0006 0.0022 0.0025
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0426 0.1487
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0054 0.0054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1266 0.1421
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0426 0.0426
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0184 0.0184
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0039 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0365 0.0365
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0426 0.0097
Echinococcus granulosus single minded 2 0.0041 0.0903 0.0903
Loa Loa (eye worm) hypothetical protein 0.0185 0.4529 0.5083
Leishmania major eukaryotic initiation factor 4a, putative 0.0359 0.8911 1
Schistosoma mansoni single-minded 0.0055 0.1264 0.1264
Brugia malayi ecdysone receptor 0.0006 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0207
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0426 0.1487
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0184 0.0184
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.121 0.1321
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0022 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.121 0.121
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0054 0.0054
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0426 0.1487
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0184 0.0184
Brugia malayi hypoxia-induced factor 1 0.0171 0.4169 0.4678
Brugia malayi MAP kinase sur-1 0.0053 0.121 0.1358
Schistosoma mansoni cpg binding protein 0.0028 0.0588 0.0588
Mycobacterium ulcerans putative regulatory protein 0.0041 0.0903 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0426 0.1487
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0359 0.8911 1
Brugia malayi hypothetical protein 0.0006 0.0022 0.0025
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0426 0.0097
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0426 0.1487
Echinococcus multilocularis nuclear receptor nhr 48 0.0006 0.0022 0.0022
Echinococcus multilocularis cpg binding protein 0.003 0.0628 0.0628
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0343 0.0343
Brugia malayi hypothetical protein 0.0286 0.706 0.7922
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0184 0.0207
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0426 0.0097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0343 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0344 0.0386
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0022 0.0025
Onchocerca volvulus 0.0006 0.0022 0.0025
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0343 0.0343
Echinococcus granulosus cpg binding protein 0.003 0.0628 0.0628
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.121 0.121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1266 0.1266
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0426 0.0217
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0184 0.0184
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0237 0.0225
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0022 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0054 0.0054
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0359 0.8911 1
Leishmania major cytochrome p450-like protein 0.0022 0.0426 0.0217
Brugia malayi hypothetical protein 0.0019 0.0365 0.041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0343 0.0121
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0184 0.0184
Onchocerca volvulus 0.0255 0.6293 0.7062
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 0.0022 0.0426 0.0478
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0184 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0184 0.0207
Brugia malayi nuclear receptor NHR-88 0.0006 0.0022 0.0025
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0365 0.041
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0022 0.0025
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.121 0.1122
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0359 0.8911 1
Schistosoma mansoni hypothetical protein 0.0019 0.0365 0.0365

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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