Detailed information for compound 1433918

Basic information

Technical information
  • TDR Targets ID: 1433918
  • Name: (2-amino-2-oxoethyl) 2-[(2-chlorophenyl)metho xy]benzoate
  • MW: 319.74 | Formula: C16H14ClNO4
  • H donors: 1 H acceptors: 2 LogP: 2.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)COC(=O)c1ccccc1OCc1ccccc1Cl
  • InChi: 1S/C16H14ClNO4/c17-13-7-3-1-5-11(13)9-21-14-8-4-2-6-12(14)16(20)22-10-15(18)19/h1-8H,9-10H2,(H2,18,19)
  • InChiKey: SZHIJFVAWFHPAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-amino-2-oxo-ethyl) 2-[(2-chlorophenyl)methoxy]benzoate
  • 2-[(2-chlorophenyl)methoxy]benzoic acid (2-amino-2-oxoethyl) ester
  • 2-(2-chlorobenzyl)oxybenzoic acid (2-amino-2-keto-ethyl) ester
  • MLS001004852
  • SMR000348408
  • ZINC03301728
  • T0512-1574

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0032 0.0087
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0015 0.0059
Schistosoma mansoni tyrosine kinase 0.008 0.0207 0.0795
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0057 0.0752
Schistosoma mansoni tyrosine kinase 0.0081 0.021 0.0806
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0015 0.0097
Brugia malayi RNA binding protein 0.0063 0.0152 0.0965
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0025
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0261 0.0999
Brugia malayi CHD4 protein 0.0015 0.0001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0057 0.0558
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0067 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.005 0.0316
Loa Loa (eye worm) hypothetical protein 0.0082 0.0214 0.1361
Mycobacterium tuberculosis Conserved hypothetical protein 0.0226 0.0663 0.0707
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0011 0.006
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0015 0.0059
Brugia malayi RNA, U transporter 1 0.0079 0.0204 0.1299
Echinococcus multilocularis cpg binding protein 0.0061 0.0146 0.056
Echinococcus granulosus pyruvate kinase 0.0017 0.0008 0.0029
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0011 0.0067
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0011 0.006
Trichomonas vaginalis ran, putative 0.0021 0.002 0.0078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0067 0.0257
Echinococcus multilocularis chromobox protein 1 0.0069 0.0173 0.0662
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0057 0.0054
Toxoplasma gondii ABC1 family protein 0.0036 0.0067 0.0907
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0042 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0049
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.025 0.1589
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0342 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.0491
Echinococcus multilocularis expressed conserved protein 0.0091 0.0242 0.0929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0049
Onchocerca volvulus 0.0036 0.0067 0.066
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.0344 0.1317
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0342 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0067 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.1574 1
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0015 0.0059
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0099 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0016
Brugia malayi Smad1 0.0016 0.0007 0.0046
Echinococcus multilocularis protein dispatched 1 0.0048 0.0105 0.0403
Brugia malayi jmjC domain containing protein 0.0095 0.0253 0.1609
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.005 0.0316
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0057 0.2061
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0013 0.0005
Leishmania major pyruvate kinase 0.0032 0.0057 0.0765
Brugia malayi amine oxidase, flavin-containing family protein 0.0226 0.0663 0.4211
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.038 0.2415
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0067 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.005 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0299 0.0315
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0013 0.0215
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0042
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0011 0.0061
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0015 0.0059
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0087 0.0332
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0106 0.1514
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.1075 0.6812
Echinococcus multilocularis smad 0.0016 0.0007 0.0028
Schistosoma mansoni hypothetical protein 0.0818 0.2523 0.9671
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0013 0.0017
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0076 0.0482
Schistosoma mansoni Smad4 0.0016 0.0007 0.0028
Mycobacterium tuberculosis Conserved protein 0.0036 0.0067 0.0065
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0155 0.0982
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.1018 0.6447
Schistosoma mansoni amine oxidase 0.0226 0.0663 0.2542
Brugia malayi beta-lactamase family protein 0.0036 0.0067 0.0427
Brugia malayi MH2 domain containing protein 0.0242 0.0714 0.4534
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0057 0.0361
Trypanosoma cruzi UDP-galactopyranose mutase 0.0226 0.0663 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0087 0.055
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.004 0.0256
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0342 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0008 0.0004
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0008 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0031 0.0373
Plasmodium falciparum thioredoxin reductase 0.0048 0.0106 0.0339
Mycobacterium ulcerans monoamine oxidase 0.0226 0.0663 0.0656
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0152 0.0582
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.1075 0.6812
Leishmania major UDP-galactopyranose mutase 0.0226 0.0663 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.025 0.0959
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.0155
Loa Loa (eye worm) TK/EGFR protein kinase 0.0151 0.0429 0.2728
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0192 0.0736
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.005 0.0191
Schistosoma mansoni hypothetical protein 0.0071 0.0177 0.0678
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0229 0.0674 1
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0008 0.0003
Leishmania major GTP-binding protein, putative 0.0021 0.002 0.0203
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0106 0.0406
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0316
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0316
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0015 0.0059
Mycobacterium ulcerans lipase LipD 0.0036 0.0067 0.0059
Echinococcus granulosus pyruvate kinase 0.0017 0.0008 0.0029
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0011 0.006
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.005 0.0191
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0152 0.0965
Onchocerca volvulus 0.003 0.005 0.0489
Echinococcus granulosus expressed conserved protein 0.0091 0.0242 0.0929
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.001 0.0015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0203
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0034
Entamoeba histolytica hypothetical protein 0.0046 0.0099 0.2678
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.005 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0042 0.0218
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.1018 0.6447
Plasmodium vivax importin-beta 2, putative 0.0028 0.0043 0.0124
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0008 0.0001
Toxoplasma gondii Alpha-galactosidase 0.0018 0.001 0.0058
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0067 0.0427
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0007 0.0046
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0025
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0057 0.0313
Brugia malayi PXA domain containing protein 0.0019 0.0015 0.0097
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0032 0.105
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.005 0.0191
Brugia malayi Thioredoxin reductase 0.0048 0.0106 0.0673
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0067 0.038
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0067 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0016 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0097
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.005 0.0316
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.005 0.0191
Brugia malayi SWIRM domain containing protein 0.0226 0.0663 0.4211
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0011 0.004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0214 0.0822
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0013 0.0251
Onchocerca volvulus Alhambra homolog 0.0029 0.0046 0.0457
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.0429 0.1646
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0005 0.0034
Schistosoma mansoni hypothetical protein 0.004 0.0082 0.0314
Trypanosoma brucei polo-like protein kinase 0.0094 0.025 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0177 0.0678
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0008 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0005 0.0034
Brugia malayi nuclear hormone receptor 0.003 0.005 0.0316
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.1018 0.6447
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.021 0.0806
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0152 0.0582
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0005 0.0034
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0008 0.0044
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0025
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.002 0.0077
Brugia malayi glutathione reductase 0.0048 0.0106 0.0673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.005 0.0316
Echinococcus multilocularis FTZ F1 alpha 0.003 0.005 0.0191
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0031 0.0366
Onchocerca volvulus 0.0057 0.0136 0.1335
Entamoeba histolytica hypothetical protein 0.0019 0.0015 0.0144
Schistosoma mansoni ran 0.0021 0.002 0.0077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0427
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.025 0.7217
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0099 0.1391
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.005 0.0316
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0152 0.0965
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.0714 0.4534
Brugia malayi nuclear receptor NHR-88 0.003 0.005 0.0316
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.005 0.0191
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.021 0.0806
Schistosoma mansoni tyrosine kinase 0.0048 0.0107 0.041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.005 0.0316
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.005 0.0191
Brugia malayi nuclear receptor RXR 0.0016 0.0005 0.0034
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.3202 1 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0016 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0097
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0015 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0049
Loa Loa (eye worm) hypothetical protein 0.0051 0.0116 0.0737
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0087 0.0332
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0046 0.0178
Echinococcus multilocularis pyruvate kinase 0.0025 0.0035 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0007 0.0046
Schistosoma mansoni hypothetical protein 0.0063 0.0155 0.0593
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0013 0.0021
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0015 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.003 0.0115
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0337 0.0356
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0077 0.076
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0067 0.038
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0099 0.0317
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0015 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.038 0.1458
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0013 0.0081
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0203
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0007 0.0028
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.095 0.2934 0.2929
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0226 0.0663 0.2542
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0011 0.0161
Plasmodium vivax hypothetical protein, conserved 0.0226 0.0663 0.2242
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0008 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0049
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0015 0.0059
Schistosoma mansoni ran 0.0021 0.002 0.0077
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0015 0.0059
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0015 0.0059
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.038 0.1458
Loa Loa (eye worm) hypothetical protein 0.0226 0.0663 0.4211
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.1018 0.6447
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0015 0.0059
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0015 0.0059
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0057 0.0361
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0015 0.0059
Brugia malayi Melibiase family protein 0.0082 0.0214 0.1361
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0018 0.001 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.1574 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0099 0.01
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0011 0.0161
Schistosoma mansoni amine oxidase 0.0226 0.0663 0.2542
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0008 0.003
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0011 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0101 0.0598
Echinococcus granulosus chromobox protein 1 0.0069 0.0173 0.0662
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0046 0.0178
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0067 0.2486
Echinococcus granulosus importin subunit beta 1 0.0028 0.0043 0.0165
Brugia malayi MH1 domain containing protein 0.0016 0.0007 0.0046
Leishmania major pyruvate kinase 0.0032 0.0057 0.0765
Schistosoma mansoni cpg binding protein 0.0061 0.0146 0.056
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0049
Schistosoma mansoni hypothetical protein 0.0063 0.0155 0.0593
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.005 0.0191
Echinococcus granulosus tar DNA binding protein 0.0063 0.0152 0.0582
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0067 0.0427
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0214 0.0822
Mycobacterium ulcerans dehydrogenase 0.0226 0.0663 0.0656
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0015 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0076 0.0291
Schistosoma mansoni hypothetical protein 0.0029 0.0046 0.0178
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.1574 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0226 0.0663 0.2542
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0013 0.0007
Brugia malayi hypothetical protein 0.0016 0.0005 0.0032
Echinococcus multilocularis neuropeptide s receptor 0.046 0.1397 0.5358
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0067 0.0257
Schistosoma mansoni tyrosine kinase 0.0048 0.0107 0.041
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0316
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0173 0.1054
Brugia malayi MH2 domain containing protein 0.0016 0.0007 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0044
Brugia malayi Heterochromatin protein 1 0.0069 0.0173 0.1098
Echinococcus granulosus dnaJ subfamily B 0.0818 0.2523 0.9671
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0011 0.0059
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0274
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.005 0.0191
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0044
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0046 0.0178
Loa Loa (eye worm) hypothetical protein 0.0226 0.0663 0.4211
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0011 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0152 0.0582
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.005 0.0191
Echinococcus multilocularis insulin receptor 0.0048 0.0107 0.041
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0028
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0299 0.0315
Schistosoma mansoni cpg binding protein 0.0061 0.0146 0.056
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0011 0.006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0067 0.0065
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0163 0.0467 0.2968
Brugia malayi chromobox protein homolog 3 0.0039 0.0077 0.0491
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0043 0.1497
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0015 0.0059
Brugia malayi MH2 domain containing protein 0.0016 0.0007 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0427
Brugia malayi beta-lactamase 0.0036 0.0067 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.005 0.0316
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0016 0.0062
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0031 0.1004
Schistosoma mansoni thyroid hormone receptor 0.003 0.005 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.038 0.1458
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0201 0.0585 0.3715
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0015 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.005 0.0191
Echinococcus multilocularis pyruvate kinase 0.0017 0.0008 0.0029
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0099 0.1414
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0057 0.0361
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0155 0.0593
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0034
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0015 0.0059
Onchocerca volvulus 0.0036 0.0067 0.066
Leishmania major importin beta-1 subunit, putative 0.0023 0.0027 0.0303
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0173 0.1054
Echinococcus granulosus geminin 0.0846 0.2608 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0015 0.0097
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0516 0.1574 1
Schistosoma mansoni hypothetical protein 0.0846 0.2608 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0001 0.0005
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0226 0.0663 0.2242
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.095 0.2934 0.3153
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.005 0.0191
Loa Loa (eye worm) hypothetical protein 0.0097 0.0261 0.1656
Echinococcus multilocularis expressed protein 0.0371 0.1119 0.4292
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0067 0.0922
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0099 0.0313
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0015 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0127
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.005 0.0191
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0008 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.1018 0.6447
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.005 0.0191
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0032 0.0155
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0031 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0067 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0013 0.0034
Leishmania major hypothetical protein, conserved 0.0036 0.0067 0.0922
Mycobacterium tuberculosis Conserved protein 0.0036 0.0067 0.0065
Giardia lamblia PHD finger protein 15 0.0029 0.0046 0.1605
Schistosoma mansoni nuclear hormone receptor 0.003 0.005 0.0191
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.0481
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0067 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0032 0.0087
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0076 0.0291
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0299 0.0315
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.0324
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.095 0.2934 0.2929
Leishmania major trypanothione reductase 0.0048 0.0106 0.1514
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.005 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.005 0.0316
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0011 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.025 0.1547
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0392 0.1501
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.005 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.005 0.0316
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0342 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0177 0.0678
Schistosoma mansoni hypothetical protein 0.0846 0.2608 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0015 0.0059
Echinococcus multilocularis pyruvate kinase 0.0017 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.025 0.1547
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0016 0.0103
Entamoeba histolytica Ran family GTPase 0.0021 0.002 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0101 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.0445
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.0155
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0226 0.0663 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0015 0.0059
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0015 0.0059
Leishmania major hypothetical protein, conserved 0.0024 0.0032 0.039
Mycobacterium tuberculosis Conserved protein 0.0036 0.0067 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0067 0.038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0057 0.0361
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0013 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0067 0.0922
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0013 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0032 0.039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.005 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Echinococcus multilocularis 0.0226 0.0663 0.2542
Plasmodium falciparum importin beta, putative 0.0028 0.0043 0.0124
Schistosoma mansoni pyruvate kinase 0.0032 0.0057 0.0218
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0057 0.0558
Loa Loa (eye worm) hypothetical protein 0.005 0.0111 0.0708
Echinococcus granulosus neuropeptide s receptor 0.046 0.1397 0.5358
Schistosoma mansoni hypothetical protein 0.0298 0.089 0.3412
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0049
Schistosoma mansoni chromobox protein 0.0069 0.0173 0.0662
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0107 0.068
Brugia malayi hypothetical protein 0.0071 0.0177 0.1124
Entamoeba histolytica hypothetical protein 0.0019 0.0015 0.0144
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.005 0.0316
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0015 0.0059
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.095 0.2934 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0013 0.0081
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0173 0.1098
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.025 0.371
Entamoeba histolytica hypothetical protein 0.0071 0.0177 0.5013
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0008 0.0003
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0026 0.0166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.038 0.1458
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0001 0.0005
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.0429 0.1646
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0295
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.025 0.0959
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0013 0.0093
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0011 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0049
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0516 0.1574 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0015 0.0097
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0057 0.0361
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0016
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0007 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0032 0.039
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0011 0.004
Brugia malayi PHD-finger family protein 0.0029 0.0046 0.0295
Loa Loa (eye worm) Smad1 0.0016 0.0007 0.0046
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0008 0.003
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.095 0.2934 0.2929
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.1574 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0008 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Plasmodium vivax glutathione reductase, putative 0.0048 0.0106 0.0339
Schistosoma mansoni importin beta-1 0.0028 0.0043 0.0165
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.025 0.371
Onchocerca volvulus 0.0226 0.0663 0.6515
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0427
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0011 0.0072
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0011 0.006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0067 0.0065
Brugia malayi hypothetical protein 0.0226 0.0663 0.4211
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0067 0.0059
Loa Loa (eye worm) hypothetical protein 0.0226 0.0663 0.4211
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0046 0.0597
Brugia malayi hypothetical protein 0.0016 0.0005 0.0034
Brugia malayi Furin-like cysteine rich region family protein 0.0151 0.0429 0.2728
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0011 0.0043
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0011 0.004
Schistosoma mansoni thyroid hormone receptor 0.003 0.005 0.0191
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0 0.0001
Schistosoma mansoni smad 0.0016 0.0007 0.0028
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0107 0.041
Echinococcus multilocularis 0.0047 0.0102 0.0392
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0338 0.1295
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0013 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0027 0.0303
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0099 0.0317
Echinococcus multilocularis peregrin 0.0029 0.0046 0.0178
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0253 0.0971
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.005 0.0191
Onchocerca volvulus Glucosylceramidase homolog 0.0339 0.1018 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.0106 0.0673
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0015 0.0097
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0021 0.0211
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0032 0.0383
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0031 0.0119
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0316
Brugia malayi beta-lactamase family protein 0.0036 0.0067 0.0427
Brugia malayi hypothetical protein 0.0024 0.0032 0.0205
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0087 0.0504
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.002 0.02
Entamoeba histolytica fatty acid elongase, putative 0.0123 0.0342 1
Echinococcus granulosus snurportin 1 0.0298 0.089 0.3412
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.005 0.0316
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0316
Entamoeba histolytica hypothetical protein 0.0071 0.0177 0.5013
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0011 0.0067
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.2469 0.9465
Plasmodium vivax hypothetical protein, conserved 0.0226 0.0663 0.2242
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0049
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.005 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0152 0.0582
Loa Loa (eye worm) hypothetical protein 0.0226 0.0663 0.4211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.0155
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0011 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0585 0.3715
Echinococcus multilocularis L aminoadipate semialdehyde 0.0163 0.0467 0.1791
Plasmodium falciparum glutathione reductase 0.0017 0.0008 0.0004
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.0344 0.1317
Echinococcus granulosus FTZ F1 alpha 0.003 0.005 0.0191
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0585 0.3715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.025 0.1547
Echinococcus granulosus chromobox protein 1 0.0069 0.0173 0.0662
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0016 0.0103
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0226 0.0663 0.0656
Plasmodium falciparum glutathione reductase 0.0048 0.0106 0.0339
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.0155
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0152 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.005 0.0316
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0015 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0067 0.038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0 0.0001
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0008 0.0004
Brugia malayi Importin beta-1 subunit 0.0028 0.0043 0.0274
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0046 0.0597
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0099 0.3812
Echinococcus multilocularis protein patched 0.0042 0.0087 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Entamoeba histolytica hypothetical protein 0.0019 0.0015 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0427
Loa Loa (eye worm) steroid hormone receptor 0.003 0.005 0.0316
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.0344 0.1317
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0297 0.4352
Schistosoma mansoni kinase 0.0048 0.0105 0.0404
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0087 0.0332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0016 0.0062
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0011 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0031 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0016
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0042
Mycobacterium tuberculosis Probable reductase 0.0109 0.0299 0.0315
Echinococcus granulosus pyruvate kinase 0.0032 0.0057 0.0218
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.005 0.0316
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0299 0.3992
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.005 0.0191
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0136 0.0863
Brugia malayi CXXC zinc finger family protein 0.0057 0.0136 0.0863
Brugia malayi CHE-14 protein 0.0042 0.0087 0.055
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0011 0.006
Echinococcus granulosus L aminoadipate semialdehyde 0.0163 0.0467 0.1791
Entamoeba histolytica hypothetical protein 0.0071 0.0177 0.5013
Echinococcus granulosus Smad4 0.0016 0.0007 0.0028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0011 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.025 0.1547
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0299 0.0315
Brugia malayi hypothetical protein 0.0016 0.0005 0.0034
Brugia malayi PXA domain containing protein 0.0019 0.0015 0.0097
Schistosoma mansoni hypothetical protein 0.004 0.0082 0.0314
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0008 0.0016
Brugia malayi Protein kinase domain containing protein 0.0048 0.0107 0.068
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0106 0.0107
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.005 0.0489
Echinococcus multilocularis snurportin 1 0.0298 0.089 0.3412
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0106 0.0406
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0008 0.0049
Schistosoma mansoni tyrosine kinase 0.0151 0.0429 0.1646
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.005 0.0191
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0008 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0013 0.0032
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0046 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.025 0.1547
Giardia lamblia Kinase, PLK 0.0094 0.025 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0 0.0001
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.095 0.2934 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0392 0.1501
Chlamydia trachomatis protoporphyrinogen oxidase 0.0226 0.0663 0.2239
Loa Loa (eye worm) hypothetical protein 0.0063 0.0155 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0057 0.0765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Chlamydia trachomatis oxoacyl-ACP synthase III 0.095 0.2934 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0011 0.0067
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.005 0.0191
Schistosoma mansoni hypothetical protein 0.0063 0.0155 0.0593
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0261 0.0999
Loa Loa (eye worm) beta-lactamase 0.0036 0.0067 0.0427
Chlamydia trachomatis pyruvate kinase 0.0032 0.0057 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0097
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0261 0.1656
Brugia malayi Steroid receptor seven-up type 2 0.003 0.005 0.0316
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.089 0.5653
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0097
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0043 0.0165
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0337 0.0356
Loa Loa (eye worm) hypothetical protein 0.0226 0.0663 0.4211
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0057 0.0558
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0548
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0007 0.0028
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0015 0.0097
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0011 0.0043
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0015 0.0059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0011 0.0067
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0057 0.0049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.005 0.0191
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0026 0.0471
Schistosoma mansoni hypothetical protein 0.004 0.0082 0.0314
Giardia lamblia Pyruvate kinase 0.0032 0.0057 0.2032
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0027 0.012
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.005 0.0191
Mycobacterium tuberculosis Possible oxidoreductase 0.0226 0.0663 0.0707
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0163 0.0467 0.1791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.1018 0.6447
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0011 0.0061
Toxoplasma gondii thioredoxin reductase 0.0048 0.0106 0.1489
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0011 0.006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.005 0.0191
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0087 0.0851
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0226 0.0663 0.2542
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0226 0.0663 0.2242
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.0445
Plasmodium falciparum pyruvate kinase 0.0032 0.0057 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.005 0.0316
Schistosoma mansoni hypothetical protein 0.004 0.0082 0.0314
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0143 0.091
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0001 0.0005
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.025 0.371
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0344 0.1317
Echinococcus granulosus smad 0.0016 0.0007 0.0028
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0253 0.0971
Toxoplasma gondii melibiase subfamily protein 0.0124 0.0344 0.5049
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.025 0.1547
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0099 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0028
Echinococcus multilocularis geminin 0.0846 0.2608 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0016
Schistosoma mansoni tyrosine kinase 0.008 0.0207 0.0795
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.0155
Echinococcus granulosus cpg binding protein 0.0061 0.0146 0.056
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0015 0.0097
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0027 0.012
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0013 0.055
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0299 0.0315
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0099 0.0313
Echinococcus multilocularis protoporphyrinogen oxidase 0.0226 0.0663 0.2542
Plasmodium falciparum phd finger protein, putative 0.0029 0.0046 0.0136
Echinococcus multilocularis dnaJ subfamily B 0.0818 0.2523 0.9671
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0043 0.0546
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.095 0.2934 1
Schistosoma mansoni hypothetical protein 0.0063 0.0155 0.0593
Echinococcus multilocularis pyruvate kinase 0.0032 0.0057 0.0218
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0099 0.0703
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0067 0.0059
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0344 0.1317
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0008 0.0016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0005 0.002
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0057 0.2061
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0344 0.1317
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.1574 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0013 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0067 0.0257
Echinococcus multilocularis pyruvate kinase 0.0017 0.0008 0.0029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0027 0.012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.005 0.0316
Brugia malayi TAR-binding protein 0.0063 0.0152 0.0965
Onchocerca volvulus 0.0036 0.0067 0.066
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.1018 0.6447
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0015 0.0097
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.025 0.2458
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0177 0.0678
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0015 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0013 0.0032
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.025 0.1589
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0152 0.0582
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0226 0.0663 0.4211
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0427
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0214 0.1319
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0155 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.005 0.0316
Loa Loa (eye worm) hypothetical protein 0.0163 0.0467 0.2968
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0057 0.0313
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0087 0.055
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0005 0.002
Toxoplasma gondii exonuclease III APE 0.0018 0.0013 0.0092
Schistosoma mansoni patched 1 0.0042 0.0087 0.0332
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0034
Schistosoma mansoni hypothetical protein 0.0137 0.0386 0.1479
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0316
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0057 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.005 0.0316
Echinococcus multilocularis Smad4 0.0016 0.0007 0.0028
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0057 0.0361
Mycobacterium ulcerans beta-lactamase 0.0036 0.0067 0.0059
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0015 0.0059
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0076 0.0291
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.1574 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.002 0.0046
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0337 0.0356
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.0155
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0155 0.0982
Brugia malayi hypothetical protein 0.0019 0.0015 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0087 0.0503
Schistosoma mansoni tyrosine kinase 0.0081 0.021 0.0806
Loa Loa (eye worm) RNA binding protein 0.0063 0.0152 0.0965
Echinococcus multilocularis pyruvate kinase 0.0032 0.0057 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0013 0.0034
Echinococcus multilocularis GPCR, family 2 0.0063 0.0155 0.0593
Plasmodium falciparum thioredoxin reductase 0.0017 0.0008 0.0004
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0015 0.0059
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0013 0.0049
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0042
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0344 0.1317
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0265 0.1018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.005 0.0316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.038 0.1458
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.005 0.0489
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0386 0.245
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0016 0.0062
Schistosoma mansoni tyrosine kinase 0.008 0.0207 0.0795
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.025 0.0959
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0032 0.0087
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0015 0.0059
Schistosoma mansoni pyruvate kinase 0.0032 0.0057 0.0218
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.038 0.2415
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0152 0.0965
Echinococcus granulosus expressed protein 0.0371 0.1119 0.4292
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0226 0.0663 0.2542
Mycobacterium ulcerans oxidoreductase 0.0226 0.0663 0.0656
Brugia malayi jmjC domain containing protein 0.0038 0.0076 0.0482
Echinococcus granulosus peregrin 0.0029 0.0046 0.0178
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.005 0.0316
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.025 0.1547
Echinococcus multilocularis chromobox protein 1 0.0069 0.0173 0.0662
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0031 0.0119
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0066 0.0251
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0155 0.0982
Echinococcus granulosus insulin receptor 0.0048 0.0107 0.041
Mycobacterium ulcerans hypothetical protein 0.0036 0.0067 0.0059
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0016 0.0062
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0087 0.0504
Brugia malayi steroid hormone receptor 0.003 0.005 0.0316
Giardia lamblia GTOR 0.0018 0.0011 0.0124
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0316
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0427
Entamoeba histolytica hypothetical protein 0.0024 0.0031 0.0619
Schistosoma mansoni cpg binding protein 0.0057 0.0136 0.0521
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0046 0.0136
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0082 0.0315
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0166
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0007 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0316
Echinococcus granulosus lysine specific histone demethylase 1A 0.0226 0.0663 0.2542
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.002 0.0077
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0008 0.0013
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0107 0.041
Trypanosoma cruzi UDP-galactopyranose mutase 0.0226 0.0663 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0067 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.038 0.1458
Loa Loa (eye worm) hypothetical protein 0.0137 0.0386 0.245
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0261 0.7537
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0057 0.0171
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0008 0.0016
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0106 0.0339
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0226 0.0663 0.2242
Brugia malayi ecdysteroid receptor 0.003 0.005 0.0316
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.2977 0.9293 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0585 0.3715
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0025
Plasmodium falciparum protoporphyrinogen oxidase 0.0226 0.0663 0.2242
Brugia malayi hypothetical protein 0.0019 0.0015 0.0097
Onchocerca volvulus Bile acid receptor homolog 0.003 0.005 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.005 0.0316
Brugia malayi MH1 domain containing protein 0.0016 0.0007 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.038 0.1458
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0106 0.0673
Trypanosoma brucei trypanothione reductase 0.0048 0.0106 0.4082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0067 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Echinococcus granulosus neuropeptide receptor A26 0.046 0.1397 0.5358
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.005 0.0191
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0013 0.0066
Brugia malayi Bromodomain containing protein 0.0029 0.0046 0.0295
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0099 0.1391
Entamoeba histolytica hypothetical protein 0.0071 0.0177 0.5013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0032 0.0155
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0043 0.1497
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0155 0.0593
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0337 0.4624
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0005 0.002
Mycobacterium leprae Probable lipase LipE 0.0036 0.0067 0.0171
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.0714 0.4534
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0001 0.0009
Toxoplasma gondii histone lysine-specific demethylase 0.0226 0.0663 0.9835
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0668 0.0713
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0226 0.0663 0.2242
Trichomonas vaginalis esterase, putative 0.0036 0.0067 0.038
Onchocerca volvulus 0.003 0.0051 0.0501
Schistosoma mansoni chromobox protein 0.0069 0.0173 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Echinococcus granulosus pyruvate kinase 0.0017 0.0008 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0007 0.0028
Echinococcus granulosus jumonji domain containing protein 0.004 0.0082 0.0315
Echinococcus granulosus GPCR family 2 0.0063 0.0155 0.0593
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.1397 0.5358
Schistosoma mansoni coup transcription factor 0.003 0.005 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0011 0.0018
Onchocerca volvulus 0.0163 0.0467 0.4591
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0011 0.0161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0031 0.0197
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0099 0.0092
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.021 0.0806
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0155 0.0593
Echinococcus granulosus pyruvate kinase 0.0032 0.0057 0.0218
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0015 0.0097
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0127
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0205

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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