Detailed information for compound 144314

Basic information

Technical information
  • TDR Targets ID: 144314
  • Name: 5-[(Z)-2-(4-bromophenyl)ethenyl]-1,2,3-trimet hoxybenzene
  • MW: 349.219 | Formula: C17H17BrO3
  • H donors: 0 H acceptors: 0 LogP: 4.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C\c2ccc(cc2)Br)cc(c1OC)OC
  • InChi: 1S/C17H17BrO3/c1-19-15-10-13(11-16(20-2)17(15)21-3)5-4-12-6-8-14(18)9-7-12/h4-11H,1-3H3/b5-4-
  • InChiKey: UBBBWYGKBDCYDY-PLNGDYQASA-N  


Substructure search Similarity search

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Synonyms

  • 5-[(Z)-2-(4-bromophenyl)vinyl]-1,2,3-trimethoxy-benzene
  • 5-[(Z)-2-(4-bromophenyl)vinyl]-1,2,3-trimethoxybenzene
  • 5-[(Z)-2-(4-bromophenyl)ethenyl]-1,2,3-trimethoxy-benzene
  • NSC638486
  • (Z) 4-BROMO-3',4',5'-TRIMETHOXYSTILBENE

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL No references
Bos taurus Tubulin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.7 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.5 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.0 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.7 %
Babesia bovis tubulin, putative Tubulin   445 aa 459 aa 21.1 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.1 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.5 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.3 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.4 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.6 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 34.0 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.2 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.3 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.8 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.4 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.6 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.5 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.6 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 34.2 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 30.1 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.0 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.4 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 33.2 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 25.8 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.6 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.2 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.3 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.4 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 90.6 %
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.4 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.1 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 33.1 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 85.8 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.4 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.2 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.4 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 93.7 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.7 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 75.7 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin alpha chain 0.0033 0.0207 0.0207
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1087 0.1087
Trichomonas vaginalis tubulin alpha chain, putative 0.0041 0.0304 0.0304
Plasmodium vivax tubulin beta chain, putative 0.0041 0.0304 0.6385
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0476 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0869 1 1
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0476 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.1744 0.1744
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0056 0.0476 0.0389
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0476 0.0389
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0292 0.3233 0.3171
Plasmodium vivax tubulin alpha chain, putative 0.0033 0.0207 0.435
Echinococcus granulosus beta tubulin 0.0041 0.0304 0.0304
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0056 0.0476 0.0389
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0418 0.0418
Schistosoma mansoni alpha tubulin 0.0033 0.0207 0.0118
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0056 0.0476 0.0389
Brugia malayi Tubulin alpha-2 chain 0.0033 0.0207 0.0118
Giardia lamblia Hypothetical protein 0.0056 0.0476 0.0389
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0056 0.0476 0.0389
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0207 0.0118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0036
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0056 0.0476 0.0389
Echinococcus granulosus tubulin alpha chain 0.0033 0.0207 0.0207
Loa Loa (eye worm) tubulin beta-1 chain 0.0041 0.0304 0.0252
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.0207 0.0118
Echinococcus multilocularis hypothetical protein 0.0033 0.0207 0.0118
Toxoplasma gondii alpha-tubulin I, putative 0.0033 0.0207 0.028
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0207 0.0207
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0056 0.0476 0.0476
Plasmodium falciparum alpha tubulin 1 0.0033 0.0207 0.3025
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0292 0.3233 0.3171
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0869 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.1087 0.1087
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0056 0.0476 0.0389
Echinococcus granulosus tubulin beta 1 chain 0.0041 0.0304 0.0304
Trichomonas vaginalis tubulin gamma chain, putative 0.0041 0.0304 0.0304
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0869 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0023 0.0089 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0476 0.0425
Entamoeba histolytica tubulin family protein 0.0041 0.0304 0.0215
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0292 0.3233 0.3171
Giardia lamblia Phosphatidylinositol 4-kinase 0.0056 0.0476 0.0389
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0361 0.4047 0.3993
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0056 0.0476 0.0389
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0692 0.7925 0.7906
Echinococcus multilocularis tubulin alpha 3 chain 0.0033 0.0207 0.0118
Trichomonas vaginalis tubulin beta chain, putative 0.0041 0.0304 0.0304
Brugia malayi Tubulin beta-1 chain 0.0041 0.0304 0.0215
Echinococcus granulosus peroxisome assembly protein 26 0.0033 0.0207 0.0207
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0056 0.0476 0.0389
Echinococcus granulosus tubulin alpha 3 chain 0.0033 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0127 0.1307 0.1228
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0164 0.1744 0.1669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.1744 0.1744
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0056 0.0476 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.3233 0.3233
Onchocerca volvulus 0.0056 0.0476 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0869 1 1
Schistosoma mansoni hypothetical protein 0.0056 0.0476 0.0389
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.0207 0.0118
Loa Loa (eye worm) alpha-tubulin 0.0033 0.0207 0.0155
Giardia lamblia Alpha-tubulin 0.0033 0.0207 0.0118
Brugia malayi tubulin alpha-2 chain 0.0033 0.0207 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.5308 0.5308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5902 0.5902
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0056 0.0476 1
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0304 0.0304
Echinococcus multilocularis beta tubulin 0.0041 0.0304 0.0215
Echinococcus granulosus tubulin alpha chain 0.0033 0.0207 0.0207
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0164 0.1744 0.1669
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0476 0.0389
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0692 0.7925 0.7906
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0056 0.0476 1
Loa Loa (eye worm) alpha-tubulin 0.0033 0.0207 0.0155
Toxoplasma gondii target of rapamycin (TOR), putative 0.0646 0.7391 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0304 0.0215
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0869 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0056 0.0476 0.0476
Entamoeba histolytica hypothetical protein 0.0056 0.0476 0.0389
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.0207 0.0207
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0476 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0056 0.0476 0.0389
Entamoeba histolytica tubulin family protein 0.0041 0.0304 0.0215
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0023 0.009 0.0122
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0207 0.0118
Echinococcus multilocularis tubulin alpha 3 chain 0.0033 0.0207 0.0118
Trichomonas vaginalis tubulin epsilon chain, putative 0.0041 0.0304 0.0304
Echinococcus granulosus tubulin alpha 1C chain 0.0033 0.0207 0.0207
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0207 0.0207
Loa Loa (eye worm) phosphatidylinositol 3 0.0869 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0207 0.0207
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0056 0.0476 0.0476
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.0207 0.0207
Echinococcus multilocularis Tubulin alpha 1 chain 0.0033 0.0207 0.0118
Loa Loa (eye worm) hypothetical protein 0.0127 0.1307 0.1261
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0056 0.0476 0.0389
Echinococcus granulosus tubulin epsilon chain 0.0023 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5902 0.5902
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.1307 0.1307
Loa Loa (eye worm) tubulin alpha 2 0.0023 0.0089 0.0036
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0056 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0108 0.1087 0.104
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.5316 0.5316
Leishmania major phosphatidylinositol 4-kinase, putative 0.0056 0.0476 0.0389
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0056 0.0476 0.0389
Trichomonas vaginalis tubulin, putative 0.0041 0.0304 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0514 0.5842 0.5842
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0476 0.0425
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0056 0.0476 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0033 0.0207 0.0118
Loa Loa (eye worm) beta-tubulin 0.0041 0.0304 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.7391 0.7391
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0869 1 1
Schistosoma mansoni alpha tubulin 0.0033 0.0207 0.0118
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0056 0.0476 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.5308 0.5308
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0164 0.1744 0.1669
Echinococcus granulosus tubulin beta 4A class IVa 0.0041 0.0304 0.0304
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Plasmodium vivax hypothetical protein 0.0056 0.0476 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0056 0.0476 0.0476
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0056 0.0476 0.0476
Trichomonas vaginalis tubulin epsilon chain, putative 0.0041 0.0304 0.0304
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0056 0.0476 1
Echinococcus granulosus tubulin gamma 1 chain 0.0023 0.009 0.009
Echinococcus multilocularis tubulin subunit TubB 0.0033 0.0207 0.0118
Loa Loa (eye worm) tubulin alpha 2 0.0023 0.0089 0.0036
Brugia malayi FAT domain containing protein 0.0127 0.1307 0.1228
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0304 0.0215
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0056 0.0476 0.0389
Schistosoma mansoni tubulin subunit alpha 0.0033 0.0207 0.0118
Toxoplasma gondii FATC domain-containing protein 0.0164 0.1744 0.236
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0476 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.3233 0.3233
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Entamoeba histolytica protein kinase rad3, putative 0.0164 0.1744 0.1669
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0869 1 1
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Echinococcus granulosus beta tubulin 0.0041 0.0304 0.0304
Entamoeba histolytica hypothetical protein 0.0164 0.1744 0.1669
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0292 0.3233 0.3233
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.3233 0.3233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0233 0.255 0.255
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0207 0.0207
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0304 0.0304
Plasmodium vivax tubulin epsilon chain, putative 0.0023 0.009 0.1898
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Loa Loa (eye worm) acetyltransferase 0.0053 0.0435 0.0384
Mycobacterium leprae conserved hypothetical protein 0.0056 0.0476 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0476 0.0389
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0304 0.0304
Loa Loa (eye worm) tubulin alpha-2 chain 0.0033 0.0207 0.0155
Loa Loa (eye worm) hypothetical protein 0.0056 0.0476 0.0425
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Giardia lamblia Beta tubulin 0.0041 0.0304 0.0215
Trypanosoma brucei beta tubulin 0.0041 0.0304 0.0215
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0164 0.1744 0.1669
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0023 0.0089 0.0036
Plasmodium vivax tubulin alpha chain, putative 0.0033 0.0207 0.435
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0056 0.0476 0.0476
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0056 0.0476 0.0389
Toxoplasma gondii beta-tubulin, putative 0.0041 0.0304 0.0411
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0127 0.1307 0.1228
Loa Loa (eye worm) BEN-1 protein 0.0041 0.0304 0.0252
Loa Loa (eye worm) hypothetical protein 0.0183 0.1964 0.1921
Entamoeba histolytica hypothetical protein 0.0056 0.0476 0.0389
Toxoplasma gondii beta-1 tubulin, putative 0.0041 0.0304 0.0411
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Giardia lamblia Alpha-tubulin 0.0033 0.0207 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0514 0.5842 0.5842
Giardia lamblia Beta tubulin 0.0041 0.0304 0.0215
Brugia malayi alpha-tubulin 0.0033 0.0207 0.0118
Schistosoma mansoni microtubule-associated protein tau 0.0251 0.2756 0.269
Trypanosoma cruzi alpha tubulin, putative 0.0033 0.0207 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.7917 0.7917
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0476 0.0389
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0164 0.1744 0.1744
Leishmania major hypothetical protein, unknown function 0.0056 0.0476 0.0389
Echinococcus granulosus tubulin alpha chain 0.0033 0.0207 0.0207
Schistosoma mansoni tubulin subunit alpha 0.0033 0.0207 0.0118
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0108 0.1087 0.1006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.7391 0.7391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.5316 0.5316
Loa Loa (eye worm) hypothetical protein 0.0177 0.1893 0.185
Loa Loa (eye worm) tubulin alpha chain 0.0033 0.0207 0.0155
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0056 0.0476 0.0389
Schistosoma mansoni tubulin subunit alpha 0.0033 0.0207 0.0118
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0056 0.0476 0.0389
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0056 0.0476 0.0476
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0056 0.0476 0.0389
Echinococcus multilocularis 0.0056 0.0476 0.0389
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0476 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0742 0.8511 0.8511
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0292 0.3233 0.3171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0476 0.0476
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0869 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0476 0.0476
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0476 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.7917 0.7917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.5316 0.5316
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0207 0.0118
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0476 0.0643
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0056 0.0476 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.5316 0.5316
Trypanosoma brucei alpha tubulin 0.0033 0.0207 0.0118
Echinococcus multilocularis serine protein kinase ATM 0.0164 0.1744 0.1669
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0292 0.3233 0.3171
Trypanosoma brucei alpha tubulin 0.0033 0.0207 0.0118
Echinococcus granulosus tubulin subunit TubB 0.0033 0.0207 0.0207
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0056 0.0476 0.0476
Echinococcus granulosus alpha tubulin 0.0033 0.0207 0.0207
Entamoeba histolytica tubulin alpha chain, putative 0.0033 0.0207 0.0118
Entamoeba histolytica hypothetical protein 0.0056 0.0476 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.1744 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.7391 0.7391
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0476 0.0389
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Trichomonas vaginalis tubulin gamma chain, putative 0.0023 0.009 0.009
Onchocerca volvulus 0.0056 0.0476 0.5
Echinococcus multilocularis beta tubulin 0.0041 0.0304 0.0215
Loa Loa (eye worm) hypothetical protein 0.0164 0.1744 0.17
Entamoeba histolytica tubulin alpha-1 chain 0.0033 0.0207 0.0118
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Brugia malayi beta-tubulin, identical 0.0041 0.0304 0.0215
Toxoplasma gondii beta tubulin 0.0041 0.0304 0.0411
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0056 0.0476 0.0389
Trypanosoma cruzi beta tubulin, putative 0.0041 0.0304 0.0215
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0304 0.0304
Echinococcus multilocularis peroxisome assembly protein 26 0.0033 0.0207 0.0118
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0476 0.0476
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0033 0.0207 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.1964 0.1964
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0127 0.1307 0.1307
Loa Loa (eye worm) tubulin alpha chain 0.0033 0.0207 0.0155
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0476 0.0389
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Plasmodium vivax tubulin gamma chain, putative 0.0023 0.009 0.1898
Loa Loa (eye worm) tubulin beta-2A chain 0.0041 0.0304 0.0252
Echinococcus granulosus microtubule associated protein 2 0.0251 0.2756 0.2756
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0869 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0033 0.0207 0.0207
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.002 0.0053 0.0053
Leishmania major hypothetical protein, conserved 0.0056 0.0476 0.0389
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0476 0.0389
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0304 0.0215
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0207 0.0118
Leishmania major phosphatidylinositol 3-kinase, putative 0.0056 0.0476 0.0389
Schistosoma mansoni tubulin subunit beta 0.0041 0.0304 0.0215
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0476 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.7391 0.7391
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0476 0.0476
Loa Loa (eye worm) tubulin gamma chain 0.0023 0.009 0.0037
Echinococcus multilocularis Zinc finger, PHD finger 0.0056 0.0476 0.0389
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0476 0.0425
Schistosoma mansoni alpha tubulin 0.0033 0.0207 0.0118
Echinococcus multilocularis tubulin alpha 1C chain 0.0033 0.0207 0.0118
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0476 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.7391 0.7391
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0056 0.0476 0.0389
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0056 0.0476 0.0389
Schistosoma mansoni tubulin subunit beta 0.0041 0.0304 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.7391 0.7391
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0053 0.0435 0.0348
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.7391 0.7391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.6648 0.6648
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0476 0.0643
Echinococcus granulosus tubulin alpha 0.0023 0.009 0.009
Schistosoma mansoni fkbp-rapamycin associated protein 0.0164 0.1744 0.1669
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0056 0.0476 0.0389
Trichomonas vaginalis tubulin alpha chain, putative 0.0023 0.009 0.009
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Giardia lamblia GTOR 0.0869 1 1
Loa Loa (eye worm) BEN-1 protein 0.0041 0.0304 0.0252
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Echinococcus granulosus tubulin alpha 3 chain 0.0033 0.0207 0.0207
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0183 0.1964 0.2658
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0056 0.0476 0.0389
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0056 0.0476 0.0389
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0476 0.0389
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0056 0.0476 0.0389
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0164 0.1744 0.1669
Trypanosoma brucei beta tubulin 0.0041 0.0304 0.0215
Trypanosoma brucei alpha tubulin 0.0033 0.0207 0.0118
Echinococcus multilocularis microtubule associated protein 2 0.0251 0.2756 0.269
Brugia malayi Tubulin alpha chain 0.0033 0.0207 0.0118
Trypanosoma cruzi target of rapamycin kinase 3 0.0692 0.7925 0.7906
Brugia malayi Tubulin alpha-2 chain 0.0033 0.0207 0.0118
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0304 0.0215
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0056 0.0476 0.0476
Trypanosoma brucei alpha tubulin 0.0033 0.0207 0.0118
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0053 0.0435 0.0348
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0056 0.0476 1
Giardia lamblia Beta tubulin 0.0041 0.0304 0.0215
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0476 0.0476
Echinococcus multilocularis tubulin subunit beta 0.0041 0.0304 0.0215
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0476 0.0476
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0056 0.0476 0.0389
Echinococcus granulosus tubulin subunit beta 0.0041 0.0304 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.7917 0.7917
Loa Loa (eye worm) phosphatidylinositol kinase 0.0056 0.0476 0.0425
Echinococcus granulosus serine protein kinase ATM 0.0164 0.1744 0.1744
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0056 0.0476 0.0389
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0164 0.1744 0.1669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.3233 0.3233
Trypanosoma brucei beta tubulin 0.0041 0.0304 0.0215
Schistosoma mansoni tubulin subunit beta 0.0041 0.0304 0.0215
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0476 0.0425
Loa Loa (eye worm) tubulin beta-4 chain 0.0041 0.0304 0.0252
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0056 0.0476 0.0389
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.3233 0.3171
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0056 0.0476 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.7917 0.7917
Loa Loa (eye worm) phosphatidylinositol 3 0.0292 0.3233 0.3197
Leishmania major alpha tubulin 0.0033 0.0207 0.0118
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0869 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0476 0.0425
Entamoeba histolytica hypothetical protein 0.0056 0.0476 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5902 0.5902
Echinococcus granulosus Tubulin alpha 1 chain 0.0033 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.3233 0.3233
Brugia malayi acetyltransferase, GNAT family protein 0.0053 0.0435 0.0348
Plasmodium falciparum tubulin beta chain 0.0041 0.0304 0.5538
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0869 1 1
Echinococcus multilocularis tubulin alpha chain 0.0033 0.0207 0.0118
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0476 0.0643
Echinococcus multilocularis tubulin beta 1 chain 0.0041 0.0304 0.0215
Brugia malayi tubulin alpha chain - mouse 0.0033 0.0207 0.0118
Loa Loa (eye worm) hypothetical protein 0.0033 0.0207 0.0155
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0476 0.0476
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.0207 0.0207
Schistosoma mansoni tubulin subunit beta 0.0041 0.0304 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 1 1
Echinococcus granulosus tubulin alpha chain 0.0033 0.0207 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 1 1
Schistosoma mansoni tubulin subunit beta 0.0041 0.0304 0.0215
Loa Loa (eye worm) tubulin beta chain 0.0041 0.0304 0.0252
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0292 0.3233 0.3171
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0476 0.0389
Toxoplasma gondii alpha tubulin TUBA1 0.0033 0.0207 0.028
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0041 0.0304 0.0215
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0292 0.3233 0.3171
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0056 0.0476 0.0389
Leishmania major phosphatidylinositol kinase related protein, putative 0.0056 0.0476 0.0389
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0056 0.0476 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0564 0.6428 0.6428
Plasmodium falciparum alpha tubulin 2 0.0033 0.0207 0.3025
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0476 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0023 0.009 0.009
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0056 0.0476 0.0389
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0056 0.0476 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.5308 0.5308
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0164 0.1744 0.1669
Leishmania major phosphatidylinositol kinase, putative 0.0056 0.0476 0.0389
Trypanosoma brucei beta tubulin 0.0041 0.0304 0.0215
Echinococcus granulosus Tubulin beta 2C chain 0.0041 0.0304 0.0304
Leishmania major phosphatidylinositol 3-kinase, putative 0.0292 0.3233 0.3171
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0056 0.0476 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0869 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0476 0.0389
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0056 0.0476 0.0476
Echinococcus granulosus tubulin alpha 1C chain 0.0033 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0056 0.0476 0.0425
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0164 0.1744 0.1669
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0056 0.0476 0.0389
Schistosoma mansoni tubulin subunit beta 0.0041 0.0304 0.0215
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0476 0.0389
Leishmania major beta tubulin 0.0041 0.0304 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.7917 0.7917
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0056 0.0476 0.0476
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0411 0.4634 0.4585
Echinococcus multilocularis Tubulin beta 2C chain 0.0041 0.0304 0.0215
Leishmania major alpha tubulin 0.0033 0.0207 0.0118

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.0067 uM Cytotoxic concentration required to inhibit 50% cell growth in SKMEL-5 melanoma cell lines ChEMBL. 1875350
ED50 (functional) = 0.0067 uM Cytotoxic concentration required to inhibit 50% cell growth in SKMEL-5 melanoma cell lines ChEMBL. 1875350
ED50 (functional) = 0.0082 uM Cytotoxic concentration required to inhibit 50% cell growth in HT-29 colon adenocarcinoma cell lines ChEMBL. 1875350
ED50 (functional) = 0.0082 uM Cytotoxic concentration required to inhibit 50% cell growth in HT-29 colon adenocarcinoma cell lines ChEMBL. 1875350
ED50 (functional) = 0.011 uM Cytotoxic concentration required to inhibit 50% cell growth in A-549 lung carcinoma cell lines ChEMBL. 1875350
ED50 (functional) = 0.011 uM Cytotoxic concentration required to inhibit 50% cell growth in A-549 lung carcinoma cell lines ChEMBL. 1875350
ED50 (functional) = 0.014 uM Cytotoxic concentration required to inhibit 50% cell growth in MLM melanoma cell lines ChEMBL. 1875350
ED50 (functional) = 0.016 uM Cytotoxic concentration required to inhibit 50% cell growth in MCF-7 breast carcinoma cell lines ChEMBL. 1875350
ED50 (functional) = 0.016 uM Cytotoxic concentration required to inhibit 50% cell growth in MCF-7 breast carcinoma cell lines ChEMBL. 1875350
GI50 (functional) -9.497 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.334 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.278 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.1 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -9.044 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.775 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.62 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8.493 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -8 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 5.51 Inhibition of tubulin polymerization in Homo sapiens (human) solid tumor cells ChEMBL. No reference
IC50 (functional) = 3.1 uM Ability to inhibit Tubulin polymerization in Bovine brain ChEMBL. 1875350
IC50 (functional) = 3.1 uM Ability to inhibit Tubulin polymerization in Bovine brain ChEMBL. 1875350
Inhibition (binding) = 73 % Effect of the compound on the binding of radiolabelled [3H]-Colchicine to tubulin ChEMBL. 1875350
Inhibition (binding) = 73 % Effect of the compound on the binding of radiolabelled [3H]-Colchicine to tubulin ChEMBL. 1875350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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