Detailed information for compound 1447100

Basic information

Technical information
  • TDR Targets ID: 1447100
  • Name: N-[4-[2-(4-methylphenyl)ethylcarbamoyl]phenyl ]-2,3-dihydro-1,4-benzothiazine-4-carboxamide
  • MW: 431.55 | Formula: C25H25N3O2S
  • H donors: 2 H acceptors: 2 LogP: 4.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CCNC(=O)c1ccc(cc1)NC(=O)N1CCSc2c1cccc2
  • InChi: 1S/C25H25N3O2S/c1-18-6-8-19(9-7-18)14-15-26-24(29)20-10-12-21(13-11-20)27-25(30)28-16-17-31-23-5-3-2-4-22(23)28/h2-13H,14-17H2,1H3,(H,26,29)(H,27,30)
  • InChiKey: KBZRMIXSINNXJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[[2-(4-methylphenyl)ethylamino]-oxomethyl]phenyl]-2,3-dihydro-1,4-benzothiazine-4-carboxamide
  • C800-0713
  • NCGC00113655-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/EGFR protein kinase 0.0096 0.2363 0.2354
Echinococcus granulosus anosmin 1 0.0073 0.1421 0.1411
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0895 0.2108
Brugia malayi protein-tyrosine kinase 0.0073 0.1424 0.2431
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0895 0.2108
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0051 0.0482 0.0471
Echinococcus granulosus Down syndrome cell adhesion molecule 0.008 0.1698 0.1688
Schistosoma mansoni cell adhesion molecule 0.012 0.3366 0.3536
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.059 0.0995
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.008 0.1698 0.1688
Schistosoma mansoni tyrosine kinase 0.0051 0.0482 0.0507
Echinococcus multilocularis insulin growth factor binding 0.0047 0.0313 0.0302
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Onchocerca volvulus 0.0047 0.0313 0.0877
Brugia malayi SPRY domain containing protein 0.0073 0.1421 0.2427
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0096 0.2363 0.2354
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.3448 0.3622
Brugia malayi Furin-like cysteine rich region family protein 0.0096 0.2363 0.4048
Echinococcus granulosus hemicentin 1 0.0053 0.059 0.0579
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.059 0.0579
Schistosoma mansoni tyrosine kinase 0.0068 0.1202 0.1263
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.059 0.0995
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.3643 0.6251
Loa Loa (eye worm) hypothetical protein 0.0073 0.1439 0.1429
Echinococcus multilocularis epidermal growth factor receptor 0.0096 0.2363 0.2354
Loa Loa (eye worm) hypothetical protein 0.0119 0.3349 0.3341
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0084 0.1894 0.1884
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0126 0.3643 0.3635
Brugia malayi myotactin form A 0.0073 0.1421 0.2427
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.008 0.1698 0.1688
Brugia malayi Peroxidasin 0.0053 0.059 0.0995
Schistosoma mansoni cell adhesion molecule 0.01 0.2547 0.2677
Brugia malayi Prion-like- 0.0047 0.0313 0.0519
Brugia malayi Protein kinase domain containing protein 0.011 0.2987 0.5122
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0755 0.7991
Onchocerca volvulus Tyrosine kinase homolog 0.0074 0.1474 0.4256
Echinococcus granulosus titin 0.0047 0.0313 0.0302
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0755 0.0744
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0047 0.0313 0.0302
Echinococcus granulosus contactin 0.0126 0.3643 0.3635
Brugia malayi Tyrosine-protein kinase abl-1 0.0148 0.4538 0.7792
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.3366 0.5775
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0895 0.0941
Entamoeba histolytica protein kinase, putative 0.0062 0.0942 1
Brugia malayi Leucine Rich Repeat family protein 0.0047 0.0313 0.0519
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0073 0.1421 0.2427
Brugia malayi SRC-1 0.0084 0.1894 0.324
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0073 0.1421 0.2427
Onchocerca volvulus 0.0073 0.1421 0.4102
Echinococcus granulosus epidermal growth factor receptor 0.0096 0.2363 0.2354
Brugia malayi MAP kinase sur-1 0.006 0.0895 0.1521
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0047 0.0313 0.0329
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.1894 0.1884
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0051 0.0482 0.0471
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0895 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.059 0.0579
Loa Loa (eye worm) plexin A 0.0045 0.0234 0.0222
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Leishmania major hypothetical protein, conserved 0.0073 0.1421 1
Schistosoma mansoni hypothetical protein 0.0073 0.1421 0.1493
Brugia malayi Animal haem peroxidase family protein 0.0047 0.0313 0.0519
Loa Loa (eye worm) hypothetical protein 0.0053 0.059 0.0579
Loa Loa (eye worm) hypothetical protein 0.0073 0.1439 0.1429
Brugia malayi Lethal protein 805 0.0073 0.1421 0.2427
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0073 0.1421 0.1493
Echinococcus granulosus tyrosine protein kinase otk 0.0053 0.059 0.0579
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0073 0.1421 0.1411
Echinococcus multilocularis roundabout 2 0.0146 0.4492 0.4485
Echinococcus granulosus peroxidasin 0.0053 0.059 0.0579
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0263 0.0251
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0073 0.1421 0.1411
Loa Loa (eye worm) TK protein kinase 0.0062 0.0942 0.0931
Onchocerca volvulus 0.0073 0.1421 0.4102
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0251 0.8873 0.8872
Schistosoma mansoni tyrosine kinase 0.0096 0.2363 0.2483
Schistosoma mansoni titin 0.0047 0.0313 0.0329
Echinococcus multilocularis tyrosine protein kinase Blk 0.0073 0.1424 0.1414
Schistosoma mansoni hypothetical protein 0.0047 0.0313 0.0329
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0313 0.0302
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0895 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.1698 0.2903
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0895 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Brugia malayi plexin A 0.0045 0.0234 0.0382
Schistosoma mansoni neuroglian 0.0126 0.3643 0.3827
Schistosoma mansoni hypothetical protein 0.0047 0.0313 0.0329
Echinococcus granulosus tyrosine protein kinase Blk 0.0073 0.1424 0.1414
Echinococcus granulosus tyrosine kinase 0.0073 0.1424 0.1414
Loa Loa (eye worm) TK protein kinase 0.0073 0.1424 0.1414
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) lethal protein 805 0.0073 0.1421 0.1411
Echinococcus multilocularis hemicentin 1 0.0053 0.059 0.0579
Echinococcus granulosus G1Y162 protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) animal heme peroxidase 0.0047 0.0313 0.0302
Onchocerca volvulus 0.0047 0.0313 0.0877
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0126 0.3643 0.3635
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0047 0.0313 0.0302
Echinococcus multilocularis anosmin 1 0.0073 0.1421 0.1411
Schistosoma mansoni tyrosine kinase 0.0084 0.1894 0.199
Brugia malayi Prion-like- 0.0053 0.059 0.0995
Echinococcus multilocularis down syndrome cell adhesion 0.0047 0.0313 0.0302
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0074 0.1474 0.1464
Echinococcus granulosus cell adhesion molecule 0.0073 0.1421 0.1411
Echinococcus multilocularis titin 0.0047 0.0313 0.0302
Schistosoma mansoni hemicentin 0.012 0.3366 0.3536
Schistosoma mansoni tyrosine kinase 0.0039 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.3366 0.5775
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0084 0.1894 0.1884
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Schistosoma mansoni tyrosine kinase 0.0051 0.0482 0.0507
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0313 0.0302
Brugia malayi Prion-like- 0.0047 0.0313 0.0519
Schistosoma mansoni cell adhesion molecule 0.012 0.3366 0.3536
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Schistosoma mansoni tyrosine kinase 0.0081 0.1751 0.184
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Echinococcus granulosus anosmin 1 0.0073 0.1421 0.1411
Brugia malayi intracellular kinase 0.0057 0.0755 0.1279
Schistosoma mansoni nephrin 0.0126 0.3643 0.3827
Schistosoma mansoni hypothetical protein 0.0047 0.0313 0.0329
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0313 0.0302
Brugia malayi Protein kinase domain containing protein 0.0178 0.582 1
Schistosoma mansoni septate junction protein 0.0053 0.059 0.062
Onchocerca volvulus 0.0047 0.0313 0.0877
Echinococcus multilocularis anosmin 1 0.0073 0.1421 0.1411
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0251 0.8873 0.8872
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0073 0.1421 0.1411
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0047 0.0313 0.0302
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0047 0.0313 0.0302
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Onchocerca volvulus Peroxidasin homolog 0.0047 0.0313 0.0877
Echinococcus granulosus insulin receptor 0.0178 0.582 0.5815
Schistosoma mansoni cell adhesion molecule 0.0126 0.3643 0.3827
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.059 0.0995
Schistosoma mansoni cell adhesion molecule 0.0053 0.059 0.062
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1421 1
Echinococcus granulosus EG95 0.0073 0.1421 0.1411
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0047 0.0313 0.0519
Brugia malayi kettin 0.0047 0.0313 0.0519
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0895 1
Echinococcus granulosus lachesin 0.0053 0.059 0.0579
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.3366 0.5775
Echinococcus multilocularis Netrin receptor DCC 0.0073 0.1421 0.1411
Echinococcus multilocularis tyrosine protein kinase otk 0.0053 0.059 0.0579
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.1894 0.1884
Loa Loa (eye worm) hypothetical protein 0.0126 0.3643 0.3635
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0084 0.1894 0.1884
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0073 0.1421 0.1493
Echinococcus granulosus neuroglian 0.0126 0.3643 0.3635
Echinococcus multilocularis tyrosine protein kinase Srms 0.0073 0.1424 0.1414
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0073 0.1421 0.2427
Echinococcus multilocularis titin 0.0047 0.0313 0.0302
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0895 0.2108
Onchocerca volvulus 0.012 0.3366 0.9762
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Schistosoma mansoni septate junction protein 0.0053 0.059 0.062
Echinococcus granulosus tyrosine protein kinase Src64B 0.0084 0.1894 0.1884
Schistosoma mansoni cell adhesion molecule 0.0126 0.3643 0.3827
Onchocerca volvulus 0.012 0.3366 0.9762
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Schistosoma mansoni titin 0.0047 0.0313 0.0329
Loa Loa (eye worm) hypothetical protein 0.012 0.3366 0.3358
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0126 0.3643 0.3635
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0895 0.2108
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0755 0.0744
Echinococcus multilocularis neuroglian 0.0126 0.3643 0.3635
Loa Loa (eye worm) hypothetical protein 0.0053 0.059 0.0579
Echinococcus multilocularis lachesin 0.0053 0.059 0.0579
Echinococcus multilocularis usherin 0.0073 0.1421 0.1411
Trypanosoma brucei protein kinase, putative 0.006 0.0895 0.2108
Echinococcus granulosus Netrin receptor DCC 0.0073 0.1421 0.1411
Brugia malayi Tyrosine-protein kinase abl-1 0.0142 0.4301 0.7385
Echinococcus granulosus epidermal growth factor receptor 0.0096 0.2363 0.2354
Echinococcus multilocularis 0.0047 0.0313 0.0302
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) hypothetical protein 0.0093 0.2271 0.2261
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0073 0.1421 0.1493
Schistosoma mansoni hypothetical protein 0.0047 0.0313 0.0329
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Loa Loa (eye worm) projectin 0.012 0.3366 0.3358
Brugia malayi Protein-tyrosine phosphatase 0.0073 0.1421 0.2427
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0073 0.1421 0.1411
Echinococcus granulosus protein kinase shaggy 0.0057 0.0755 0.0744
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0073 0.1421 0.1411
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0895 1
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0073 0.1421 0.1411
Schistosoma mansoni titin 0.0047 0.0313 0.0329
Echinococcus multilocularis titin 0.0121 0.3448 0.344
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.059 0.0995
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0895 0.0885
Echinococcus multilocularis roundabout 2 0.0126 0.3643 0.3635
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.012 0.3366 0.3358
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0755 0.0744
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Echinococcus granulosus nephrin 0.012 0.3366 0.3358
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Onchocerca volvulus Peroxidasin homolog 0.0047 0.0313 0.0877
Brugia malayi Fibronectin type III domain containing protein 0.0073 0.1421 0.2427
Schistosoma mansoni tripartite motif protein trim9 0.0073 0.1421 0.1493
Brugia malayi myotactin form B 0.0073 0.1421 0.2427
Loa Loa (eye worm) hypothetical protein 0.0053 0.059 0.0579
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0073 0.1421 0.1411
Echinococcus granulosus roundabout 2 0.0146 0.4492 0.4485
Echinococcus granulosus plexin a4 0.0045 0.0234 0.0222
Schistosoma mansoni titin 0.0053 0.059 0.062
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0073 0.1421 0.1411
Loa Loa (eye worm) hypothetical protein 0.0093 0.2271 0.2261
Schistosoma mansoni titin 0.0047 0.0313 0.0329
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0047 0.0313 0.0302
Brugia malayi Prion-like- 0.0047 0.0313 0.0519
Echinococcus multilocularis insulin receptor 0.0178 0.582 0.5815
Echinococcus multilocularis twitchin 0.0048 0.0395 0.0383
Onchocerca volvulus 0.0121 0.3448 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Loa Loa (eye worm) TK/ABL protein kinase 0.0278 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.012 0.3366 0.3358
Brugia malayi hypothetical protein 0.0073 0.1421 0.2427
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.1424 0.1414
Echinococcus multilocularis plexin a4 0.0045 0.0234 0.0222
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0755 0.0744
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.3366 0.5775
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0895 0.0885
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0053 0.059 0.1682
Onchocerca volvulus 0.0047 0.0313 0.0877
Onchocerca volvulus 0.0047 0.0313 0.0877
Loa Loa (eye worm) hypothetical protein 0.0053 0.059 0.0579
Echinococcus multilocularis c src tyrosine kinase 0.0051 0.0482 0.0471
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) hypothetical protein 0.012 0.3366 0.3358
Schistosoma mansoni tyrosine kinase 0.0084 0.1894 0.199
Echinococcus multilocularis Fibronectin, type III 0.0073 0.1421 0.1411
Loa Loa (eye worm) TK/ROR protein kinase 0.0074 0.1474 0.1464
Brugia malayi Immunoglobulin I-set domain containing protein 0.0121 0.3448 0.5916
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0895 0.0885
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0084 0.1894 0.1884
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.059 0.0995
Echinococcus multilocularis tyrosine protein kinase Abl 0.0142 0.4301 0.4294
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0073 0.1421 0.1411
Onchocerca volvulus 0.0047 0.0313 0.0877
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0895 0.0885
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.3366 0.5775
Schistosoma mansoni titin 0.012 0.3366 0.3536
Onchocerca volvulus 0.0073 0.1421 0.4102
Loa Loa (eye worm) hypothetical protein 0.0083 0.1825 0.1816
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0128 0.3725 0.3717
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.1894 0.1884
Schistosoma mansoni myosin-binding protein-related 0.012 0.3366 0.3536
Entamoeba histolytica protein kinase, putative 0.0057 0.0755 0.7991
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0656 0.1109
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Onchocerca volvulus 0.0057 0.0755 0.2162
Onchocerca volvulus Netrin receptor homolog 0.0047 0.0313 0.0877
Schistosoma mansoni factor for adipocyte differentiation 0.0073 0.1421 0.1493
Schistosoma mansoni tyrosine kinase 0.0267 0.9518 1
Brugia malayi Myb-like DNA-binding domain containing protein 0.0047 0.0313 0.0519
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0126 0.3643 0.3827
Echinococcus granulosus usherin 0.0073 0.1421 0.1411
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.059 0.0995
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0755 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0055 0.0656 0.0645
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.3643 0.6251
Loa Loa (eye worm) CAMK protein kinase 0.0121 0.3448 0.344
Echinococcus granulosus Netrin receptor DCC 0.0073 0.1421 0.1411
Echinococcus multilocularis titin 0.0047 0.0313 0.0302
Brugia malayi Fibronectin type III domain containing protein 0.0093 0.2271 0.3889
Echinococcus multilocularis peroxidasin 0.0053 0.059 0.0579
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0073 0.1421 0.1493
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0051 0.0482 0.0507
Brugia malayi Fibronectin type III domain containing protein 0.0073 0.1421 0.2427
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0084 0.1894 0.1884
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.012 0.3366 0.3358
Schistosoma mansoni titin 0.0047 0.0313 0.0329
Echinococcus granulosus insulin growth factor binding 0.0047 0.0313 0.0302
Loa Loa (eye worm) disorganized muscle protein 1 0.0047 0.0313 0.0302
Loa Loa (eye worm) one IG domain family member 0.0047 0.0313 0.0302
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.1894 0.1884
Brugia malayi Lethal protein 805 0.0073 0.1421 0.2427
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0263 0.0251
Schistosoma mansoni tyrosine kinase 0.0178 0.582 0.6115
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0126 0.3643 0.3635
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0121 0.3448 0.344
Echinococcus granulosus titin 0.0047 0.0313 0.0302
Schistosoma mansoni tyrosine kinase 0.0039 0.0012 0.0013
Brugia malayi Disorganized muscle protein 1 0.0047 0.0313 0.0519
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.012 0.3366 0.3358
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0073 0.1421 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.1474 0.2518
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) hypothetical protein 0.0093 0.2271 0.2261
Brugia malayi hypothetical protein 0.0093 0.2271 0.3889
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0084 0.1894 0.1884
Echinococcus granulosus Fibronectin type III 0.0073 0.1421 0.1411
Echinococcus granulosus titin 0.0047 0.0313 0.0302
Echinococcus granulosus neuroglian 0.0067 0.1162 0.1152
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0895 0.0885
Echinococcus granulosus fibronectin type III domain-containing protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0313 0.0302
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0053 0.059 0.062
Brugia malayi Fibronectin type III domain containing protein 0.0073 0.1421 0.2427
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0895 0.2108
Loa Loa (eye worm) SRC-1 0.0084 0.1894 0.1884
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0755 0.0744
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0084 0.1894 0.1884
Echinococcus multilocularis Netrin receptor DCC 0.0073 0.1421 0.1411
Echinococcus granulosus roundabout 2 0.0126 0.3643 0.3635
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0895 1
Onchocerca volvulus 0.0047 0.0313 0.0877
Schistosoma mansoni titin 0.0121 0.3448 0.3622
Schistosoma mansoni nephrin related 0.0047 0.0313 0.0329
Schistosoma mansoni titin 0.0073 0.1421 0.1493
Brugia malayi protein unc-22 0.0121 0.3448 0.5916
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0047 0.0313 0.0302
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0278 1 1
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0073 0.1421 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1421 0.1411
Schistosoma mansoni ephrin receptor 0.0101 0.2583 0.2714
Schistosoma mansoni hypothetical protein 0.0047 0.0313 0.0329
Echinococcus granulosus anosmin 1 0.0073 0.1421 0.1411
Onchocerca volvulus 0.0073 0.1421 0.4102
Schistosoma mansoni factor for adipocyte differentiation 0.0073 0.1421 0.1493
Schistosoma mansoni hypothetical protein 0.0047 0.0313 0.0329
Loa Loa (eye worm) TK protein kinase 0.0074 0.1474 0.1464
Loa Loa (eye worm) hypothetical protein 0.0053 0.059 0.0579
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0126 0.3643 0.3635
Loa Loa (eye worm) UNCoordinated family member 0.0073 0.1421 0.1411
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.059 0.0579
Loa Loa (eye worm) TK/INSR protein kinase 0.0178 0.582 0.5815
Echinococcus granulosus titin 0.0121 0.3448 0.344
Schistosoma mansoni tyrosine kinase 0.0096 0.2363 0.2483
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Echinococcus multilocularis cell adhesion molecule 0.0073 0.1421 0.1411
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0755 0.0793
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0755 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0755 0.7991
Echinococcus granulosus c src tyrosine kinase 0.0051 0.0482 0.0471
Onchocerca volvulus 0.0073 0.1421 0.4102
Echinococcus multilocularis neuroglian 0.0067 0.1162 0.1152
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.1894 0.1884
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0053 0.059 0.0579
Onchocerca volvulus 0.0073 0.1421 0.4102
Loa Loa (eye worm) myotactin form A 0.0073 0.1421 0.1411
Onchocerca volvulus Putative titin 0.0047 0.0313 0.0877
Schistosoma mansoni hypothetical protein 0.0073 0.1421 0.1493
Schistosoma mansoni factor for adipocyte differentiation 0.0073 0.1421 0.1493
Schistosoma mansoni tyrosine kinase 0.0068 0.1202 0.1263
Schistosoma mansoni slit 0.0047 0.0313 0.0329
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0895 0.2108
Echinococcus multilocularis anosmin 1 0.0073 0.1421 0.1411
Echinococcus granulosus tyrosine protein kinase Lyn 0.0086 0.1976 0.1966
Schistosoma mansoni roundabout 0.0053 0.059 0.062
Echinococcus granulosus roundabout 2 0.0126 0.3643 0.3635
Schistosoma mansoni hypothetical protein 0.012 0.3366 0.3536
Onchocerca volvulus 0.0047 0.0313 0.0877
Onchocerca volvulus 0.0073 0.1421 0.4102
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0073 0.1421 0.1411
Brugia malayi Fibronectin type III domain containing protein 0.0073 0.1421 0.2427
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0895 0.2108
Echinococcus granulosus titin 0.0121 0.3448 0.344
Echinococcus multilocularis transfer RNA-Phe 0.012 0.3366 0.3358
Echinococcus granulosus Fibronectin type III domain containing protein 0.0073 0.1421 0.1411
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.3366 0.5775
Echinococcus granulosus tyrosine protein kinase HCK 0.0062 0.0942 0.0931
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.1894 0.1884
Onchocerca volvulus 0.0073 0.1421 0.4102
Echinococcus granulosus down syndrome cell adhesion 0.0047 0.0313 0.0302
Echinococcus granulosus twitchin 0.0069 0.1244 0.1234
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0073 0.1421 0.1411
Echinococcus multilocularis tyrosine protein kinase HCK 0.0062 0.0942 0.0931
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0313 0.0519
Onchocerca volvulus 0.0073 0.1421 0.4102
Echinococcus multilocularis roundabout 2 0.0126 0.3643 0.3635
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0084 0.1894 0.1884
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0126 0.3643 0.3635
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0313 0.0302
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0073 0.1424 0.1414
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Schistosoma mansoni cell adhesion molecule 0.0047 0.0313 0.0329
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0074 0.1474 0.1464
Schistosoma mansoni protein tyrosine phosphatase 0.0073 0.1421 0.1493
Onchocerca volvulus 0.0073 0.1421 0.4102
Schistosoma mansoni tyrosine kinase 0.0068 0.1202 0.1263
Loa Loa (eye worm) hypothetical protein 0.0053 0.059 0.0579
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.3643 0.6251
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0073 0.1421 0.1411
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0395 0.0415
Echinococcus multilocularis hemicentin 1 0.0053 0.059 0.0579
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0073 0.1421 1
Schistosoma mansoni tyrosine kinase 0.0096 0.2363 0.2483
Loa Loa (eye worm) hypothetical protein 0.0047 0.0313 0.0302
Echinococcus granulosus leucine rich repeat containing protein 4 0.0047 0.0313 0.0302
Echinococcus multilocularis titin 0.0073 0.1421 0.1411
Echinococcus granulosus tyrosine protein kinase Src42A 0.0084 0.1894 0.1884
Onchocerca volvulus 0.0073 0.1421 0.4102
Brugia malayi Fibronectin type III domain containing protein 0.0073 0.1421 0.2427
Brugia malayi Immunoglobulin I-set domain containing protein 0.0093 0.2271 0.3889
Echinococcus multilocularis epidermal growth factor receptor 0.0096 0.2363 0.2354
Schistosoma mansoni nephrin 0.014 0.4215 0.4429
Schistosoma mansoni tyrosine kinase 0.0178 0.582 0.6115

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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