Detailed information for compound 1447357

Basic information

Technical information
  • TDR Targets ID: 1447357
  • Name: (4-phenylpiperazin-1-yl)-[1-[4-(tetrazol-1-yl )phenyl]sulfonylpiperidin-4-yl]methanone
  • MW: 481.571 | Formula: C23H27N7O3S
  • H donors: 0 H acceptors: 6 LogP: 1.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)c1ccccc1)C1CCN(CC1)S(=O)(=O)c1ccc(cc1)n1cnnn1
  • InChi: 1S/C23H27N7O3S/c31-23(28-16-14-27(15-17-28)20-4-2-1-3-5-20)19-10-12-29(13-11-19)34(32,33)22-8-6-21(7-9-22)30-18-24-25-26-30/h1-9,18-19H,10-17H2
  • InChiKey: WUSIUIAVNIUMGR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-phenylpiperazin-1-yl)-[1-[4-(tetrazol-1-yl)phenyl]sulfonyl-4-piperidyl]methanone
  • (4-phenyl-1-piperazinyl)-[1-[4-(1-tetrazolyl)phenyl]sulfonyl-4-piperidinyl]methanone
  • (4-phenylpiperazin-1-yl)-[1-[4-(1,2,3,4-tetrazol-1-yl)phenyl]sulfonylpiperidin-4-yl]methanone
  • ASN 05946172
  • SMR000005891
  • (4-Phenyl-piperazin-1-yl)-[1-(4-tetrazol-1-yl-benzenesulfonyl)-piperidin-4-yl]-methanone
  • MLS000034576
  • MLS000889334

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Schistosoma mansoni cell adhesion molecule 0.0105 0.2567 0.2567
Schistosoma mansoni titin 0.0104 0.2523 0.2523
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0208 0.5968 0.8905
Loa Loa (eye worm) animal heme peroxidase 0.0043 0.0503 0.0497
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0778 0.0101
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0063 0.1166 0.1734
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0778 0.0101
Onchocerca volvulus 0.0102 0.2468 0.9782
Schistosoma mansoni slit 0.0043 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0102 0.2468 0.2464
Loa Loa (eye worm) hypothetical protein 0.0046 0.0601 0.0596
Brugia malayi myotactin form A 0.0059 0.105 0.1045
Schistosoma mansoni tyrosine kinase 0.0063 0.1166 0.1166
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0105 0.2567 0.3825
Brugia malayi hypothetical protein 0.0069 0.1352 0.1347
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0102 0.2468 0.2464
Loa Loa (eye worm) hypothetical protein 0.0099 0.2346 0.2341
Echinococcus multilocularis tyrosine protein kinase Abl 0.0112 0.278 0.4144
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.1166 0.1734
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0684 0.9337
Echinococcus granulosus protein kinase shaggy 0.0048 0.0684 0.1013
Echinococcus multilocularis tyrosine protein kinase Blk 0.0056 0.0952 0.1414
Echinococcus granulosus hemicentin 1 0.0046 0.0601 0.089
Schistosoma mansoni ephrin receptor 0.0081 0.1751 0.1751
Brugia malayi Protein kinase domain containing protein 0.0091 0.2103 0.2098
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0105 0.2567 0.3825
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0059 0.105 0.1559
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0046 0.0601 0.0596
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0063 0.1166 0.1734
Brugia malayi Peroxidasin 0.0046 0.0601 0.0596
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0104 0.2523 0.2519
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0063 0.1166 0.1734
Loa Loa (eye worm) hypothetical protein 0.0055 0.0903 0.0898
Loa Loa (eye worm) hypothetical protein 0.0046 0.0601 0.0596
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0033 0.0186 0.0181
Loa Loa (eye worm) lethal protein 805 0.0059 0.105 0.1045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0911 0.1352
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.1685 0.2508
Echinococcus multilocularis hemicentin 1 0.0046 0.0601 0.089
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Onchocerca volvulus 0.0059 0.105 0.4147
Echinococcus granulosus cell adhesion molecule 0.0059 0.105 0.1559
Echinococcus multilocularis hemicentin 1 0.0046 0.0601 0.089
Schistosoma mansoni tyrosine kinase 0.0057 0.0984 0.0984
Brugia malayi Myb-like DNA-binding domain containing protein 0.0043 0.0503 0.0497
Schistosoma mansoni tyrosine kinase 0.0057 0.0984 0.0984
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0063 0.1166 0.1734
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0601 0.0596
Schistosoma mansoni titin 0.0043 0.0503 0.0503
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.1166 0.1734
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0778 0.2576
Echinococcus granulosus peroxidasin 0.0046 0.0601 0.089
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0911 0.0906
Brugia malayi Prion-like- 0.0043 0.0503 0.0497
Schistosoma mansoni tyrosine kinase 0.0034 0.022 0.022
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0102 0.2468 0.2464
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.1204 0.1199
Echinococcus granulosus Netrin receptor DCC 0.0059 0.105 0.1559
Echinococcus granulosus tyrosine protein kinase Blk 0.0056 0.0952 0.1414
Echinococcus multilocularis c src tyrosine kinase 0.0034 0.022 0.032
Trypanosoma brucei protein kinase, putative 0.0051 0.0778 0.2576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0601 0.0596
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0059 0.105 1
Loa Loa (eye worm) UNCoordinated family member 0.0059 0.105 0.1045
Echinococcus granulosus anosmin 1 0.0059 0.105 0.1559
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Schistosoma mansoni neuroglian 0.0105 0.2567 0.2567
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0043 0.0503 0.0743
Onchocerca volvulus Peroxidasin homolog 0.0043 0.0503 0.1975
Schistosoma mansoni hypothetical protein 0.0043 0.0503 0.0503
Echinococcus granulosus tyrosine protein kinase Src64B 0.0063 0.1166 0.1734
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0778 0.2576
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0778 0.2576
Onchocerca volvulus 0.0059 0.105 0.4147
Schistosoma mansoni titin 0.0043 0.0503 0.0503
Brugia malayi Leucine Rich Repeat family protein 0.0043 0.0503 0.0497
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.2468 0.2464
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0186 0.0181
Loa Loa (eye worm) glutaminase 2 0.033 1 1
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0059 0.105 0.1559
Echinococcus granulosus tyrosine kinase 0.0056 0.0952 0.1414
Schistosoma mansoni factor for adipocyte differentiation 0.0059 0.105 0.105
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0043 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0046 0.0601 0.0596
Echinococcus multilocularis peroxidasin 0.0046 0.0601 0.089
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0208 0.5968 0.8905
Brugia malayi SPRY domain containing protein 0.0059 0.105 0.1045
Brugia malayi Animal haem peroxidase family protein 0.0043 0.0503 0.0497
Schistosoma mansoni septate junction protein 0.0046 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0059 0.105 0.1045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0069 0.1352 0.1347
Echinococcus multilocularis transfer RNA-Phe 0.0102 0.2468 0.3678
Echinococcus granulosus EG95 0.0059 0.105 0.1559
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0043 0.0503 0.0743
Echinococcus multilocularis titin 0.0104 0.2523 0.376
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0043 0.0503 0.0743
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0251 0.0366
Onchocerca volvulus 0.0059 0.105 0.4147
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0063 0.1166 0.1734
Schistosoma mansoni titin 0.0043 0.0503 0.0503
Schistosoma mansoni titin 0.0046 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0069 0.1352 0.1347
Echinococcus multilocularis anosmin 1 0.0059 0.105 0.1559
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0105 0.2567 0.3825
Echinococcus granulosus titin 0.0043 0.0503 0.0743
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Echinococcus granulosus leucine rich repeat containing protein 4 0.0043 0.0503 0.0743
Plasmodium falciparum glycogen synthase kinase 3 0.0048 0.0684 0.5
Echinococcus granulosus Netrin receptor DCC 0.0059 0.105 0.1559
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0059 0.105 1
Loa Loa (eye worm) myotactin form A 0.0059 0.105 0.1045
Echinococcus multilocularis tyrosine protein kinase ABL1 0.023 0.6701 1
Schistosoma mansoni cell adhesion molecule 0.0043 0.0503 0.0503
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0062 0.1148 0.1706
Echinococcus multilocularis titin 0.0043 0.0503 0.0743
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.1166 0.1734
Schistosoma mansoni nephrin related 0.0043 0.0503 0.0503
Mycobacterium ulcerans glutaminase 0.033 1 0.5
Schistosoma mansoni tripartite motif protein trim9 0.0059 0.105 0.105
Echinococcus granulosus c src tyrosine kinase 0.0034 0.022 0.032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0046 0.0601 0.2366
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0043 0.0503 0.0743
Echinococcus granulosus Fibronectin type III domain containing protein 0.0059 0.105 0.1559
Brugia malayi follicle stimulating hormone receptor 0.028 0.8333 0.8332
Echinococcus multilocularis titin 0.0043 0.0503 0.0743
Echinococcus granulosus roundabout 2 0.0105 0.2567 0.3825
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0034 0.022 0.022
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0778 0.0773
Brugia malayi Lethal protein 805 0.0059 0.105 0.1045
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0251 0.0366
Loa Loa (eye worm) hypothetical protein 0.0046 0.0601 0.0596
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.1166 0.1734
Onchocerca volvulus 0.0043 0.0503 0.1975
Onchocerca volvulus 0.0104 0.2523 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1352 0.1347
Echinococcus granulosus insulin receptor 0.0149 0.4002 0.5969
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0684 0.9337
Schistosoma mansoni titin 0.0102 0.2468 0.2468
Brugia malayi kettin 0.0043 0.0503 0.0497
Echinococcus granulosus titin 0.0043 0.0503 0.0743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0059 0.105 0.1045
Schistosoma mansoni nephrin 0.0111 0.277 0.277
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0059 0.105 0.1559
Echinococcus multilocularis protein kinase shaggy 0.0048 0.0684 0.1013
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0064 0.1204 0.179
Echinococcus multilocularis roundabout 2 0.0114 0.2869 0.4276
Loa Loa (eye worm) TK protein kinase 0.0064 0.1204 0.1199
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0059 0.105 0.1559
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0102 0.2468 0.3678
Onchocerca volvulus 0.0043 0.0503 0.1975
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0043 0.0503 0.0743
Schistosoma mansoni cell adhesion molecule 0.0046 0.0601 0.0601
Echinococcus granulosus neuroglian 0.0052 0.0805 0.1194
Onchocerca volvulus 0.0043 0.0503 0.1975
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0059 0.105 0.1045
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0046 0.0601 0.089
Echinococcus multilocularis lachesin 0.0046 0.0601 0.089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0105 0.2567 0.2567
Schistosoma mansoni tyrosine kinase 0.0028 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0102 0.2468 0.2464
Echinococcus multilocularis insulin receptor 0.0149 0.4002 0.5969
Echinococcus granulosus anosmin 1 0.0059 0.105 0.1559
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0059 0.105 0.1559
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0911 0.1352
Entamoeba histolytica protein kinase, putative 0.005 0.0732 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0048 0.0684 0.0679
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0107 0.2621 0.2617
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0778 0.0101
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0911 0.0906
Echinococcus granulosus roundabout 2 0.0105 0.2567 0.3825
Onchocerca volvulus 0.0102 0.2468 0.9782
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0503 0.0497
Echinococcus granulosus anosmin 1 0.0059 0.105 0.1559
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.105 0.1045
Schistosoma mansoni myosin-binding protein-related 0.0102 0.2468 0.2468
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0043 0.0503 0.0497
Echinococcus granulosus titin 0.0104 0.2523 0.376
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0778 0.1154
Onchocerca volvulus 0.0059 0.105 0.4147
Loa Loa (eye worm) CAMK protein kinase 0.0104 0.2523 0.2519
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0059 0.105 0.1045
Echinococcus multilocularis roundabout 2 0.0105 0.2567 0.3825
Brugia malayi Immunoglobulin I-set domain containing protein 0.0105 0.2567 0.2562
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0778 0.2576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0601 0.0596
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0034 0.022 0.032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Echinococcus granulosus Fibronectin type III 0.0059 0.105 0.1559
Brugia malayi hypothetical protein 0.0059 0.105 0.1045
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0778 0.2576
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0778 0.1154
Schistosoma mansoni hypothetical protein 0.0059 0.105 0.105
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0059 0.105 0.105
Echinococcus granulosus nephrin 0.0102 0.2468 0.3678
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0601 0.0596
Schistosoma mansoni factor for adipocyte differentiation 0.0059 0.105 0.105
Onchocerca volvulus 0.0043 0.0503 0.1975
Onchocerca volvulus 0.0059 0.105 0.4147
Brugia malayi Furin-like cysteine rich region family protein 0.0079 0.1685 0.168
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0059 0.105 0.1045
Schistosoma mansoni hypothetical protein 0.0043 0.0503 0.0503
Brugia malayi intracellular kinase 0.0048 0.0684 0.0679
Echinococcus granulosus twitchin 0.0054 0.086 0.1276
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.2468 0.2464
Brugia malayi MAP kinase sur-1 0.0051 0.0778 0.0773
Echinococcus multilocularis usherin 0.0059 0.105 0.1559
Echinococcus multilocularis down syndrome cell adhesion 0.0043 0.0503 0.0743
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.2468 0.2464
Loa Loa (eye worm) glutaminase 0.033 1 1
Brugia malayi Disorganized muscle protein 1 0.0043 0.0503 0.0497
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.2523 0.2519
Loa Loa (eye worm) hypothetical protein 0.0046 0.0601 0.0596
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.8333 0.8332
Onchocerca volvulus Peroxidasin homolog 0.0043 0.0503 0.1975
Schistosoma mansoni titin 0.0043 0.0503 0.0503
Schistosoma mansoni hypothetical protein 0.0043 0.0503 0.0503
Schistosoma mansoni tyrosine kinase 0.0079 0.1685 0.1685
Echinococcus multilocularis Netrin receptor DCC 0.0059 0.105 0.1559
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0048 0.0684 0.0684
Echinococcus granulosus insulin growth factor binding 0.0043 0.0503 0.0743
Brugia malayi Protein kinase domain containing protein 0.0149 0.4002 0.3999
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.105 0.1045
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0048 0.0684 0.0679
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.105 0.1045
Brugia malayi myotactin form B 0.0059 0.105 0.1045
Onchocerca volvulus Tyrosine kinase homolog 0.0064 0.1204 0.4761
Loa Loa (eye worm) TK/INSR protein kinase 0.0149 0.4002 0.3999
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0063 0.1166 0.1734
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0059 0.105 0.1045
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.2523 0.2523
Brugia malayi protein unc-22 0.0104 0.2523 0.2519
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0778 0.2576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Brugia malayi Protein-tyrosine phosphatase 0.0059 0.105 0.1045
Schistosoma mansoni tyrosine kinase 0.0149 0.4002 0.4002
Echinococcus multilocularis tyrosine protein kinase otk 0.0046 0.0601 0.089
Brugia malayi Fibronectin type III domain containing protein 0.0069 0.1352 0.1347
Echinococcus multilocularis neuroglian 0.0052 0.0805 0.1194
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0105 0.2567 0.3825
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.1166 0.1734
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0062 0.1148 0.1706
Schistosoma mansoni tyrosine kinase 0.0067 0.1303 0.1303
Schistosoma mansoni tyrosine kinase 0.0034 0.022 0.022
Schistosoma mansoni cell adhesion molecule 0.0102 0.2468 0.2468
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Loa Loa (eye worm) hypothetical protein 0.0046 0.0601 0.0596
Plasmodium vivax glycogen synthase kinase 3, putative 0.0048 0.0684 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Brugia malayi Prion-like- 0.0043 0.0503 0.0497
Schistosoma mansoni cell adhesion molecule 0.0072 0.145 0.145
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0034 0.022 0.032
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0059 0.105 0.1559
Echinococcus granulosus tyrosine protein kinase otk 0.0046 0.0601 0.089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.105 0.1045
Onchocerca volvulus 0.0048 0.0684 0.2695
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.1685 0.2508
Schistosoma mansoni hypothetical protein 0.0043 0.0503 0.0503
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0059 0.105 0.1559
Echinococcus granulosus titin 0.0104 0.2523 0.376
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Echinococcus granulosus tyrosine protein kinase HCK 0.005 0.0732 0.1085
Echinococcus multilocularis neuroglian 0.0105 0.2567 0.3825
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0778 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0046 0.0601 0.0601
Schistosoma mansoni factor for adipocyte differentiation 0.0059 0.105 0.105
Schistosoma mansoni hypothetical protein 0.0043 0.0503 0.0503
Echinococcus granulosus contactin 0.0105 0.2567 0.3825
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0059 0.105 0.105
Trichomonas vaginalis glutaminase, putative 0.033 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0778 0.0778
Onchocerca volvulus Netrin receptor homolog 0.0043 0.0503 0.1975
Loa Loa (eye worm) one IG domain family member 0.0043 0.0503 0.0497
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0778 0.1154
Loa Loa (eye worm) TK protein kinase 0.005 0.0732 0.0727
Schistosoma mansoni hypothetical protein 0.0102 0.2468 0.2468
Echinococcus granulosus tyrosine protein kinase Src42A 0.0063 0.1166 0.1734
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.1685 0.2508
Echinococcus multilocularis anosmin 1 0.0059 0.105 0.1559
Loa Loa (eye worm) TK/EGFR protein kinase 0.0079 0.1685 0.168
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0063 0.1166 0.1734
Echinococcus multilocularis Netrin receptor DCC 0.0059 0.105 0.1559
Schistosoma mansoni hemicentin 0.0102 0.2468 0.2468
Loa Loa (eye worm) hypothetical protein 0.0046 0.0601 0.0596
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0043 0.0503 0.0743
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0601 0.0596
Loa Loa (eye worm) hypothetical protein 0.0105 0.2567 0.2562
Echinococcus multilocularis roundabout 2 0.0105 0.2567 0.3825
Schistosoma mansoni tyrosine kinase 0.0224 0.6481 0.6481
Echinococcus multilocularis 0.0043 0.0503 0.0743
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0503 0.0497
Echinococcus granulosus fibronectin type III domain-containing protein 0.0059 0.105 0.1559
Brugia malayi Prion-like- 0.0043 0.0503 0.0497
Loa Loa (eye worm) hypothetical protein 0.007 0.1401 0.1397
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Echinococcus multilocularis twitchin 0.0045 0.0558 0.0825
Schistosoma mansoni hypothetical protein 0.0043 0.0503 0.0503
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.2468 0.2464
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Brugia malayi Fibronectin type III domain containing protein 0.0059 0.105 0.1045
Onchocerca volvulus 0.0059 0.105 0.4147
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.1166 0.1734
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.1148 0.1143
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.2468 0.2464
Onchocerca volvulus 0.0059 0.105 0.4147
Echinococcus granulosus usherin 0.0059 0.105 0.1559
Schistosoma mansoni glutaminase 0.033 1 1
Echinococcus granulosus neuroglian 0.0105 0.2567 0.3825
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0059 0.105 0.105
Echinococcus multilocularis titin 0.0043 0.0503 0.0743
Onchocerca volvulus 0.0043 0.0503 0.1975
Brugia malayi Immunoglobulin I-set domain containing protein 0.0105 0.2567 0.2562
Brugia malayi Tyrosine-protein kinase abl-1 0.0112 0.278 0.2776
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0778 0.2576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.1148 0.1143
Echinococcus granulosus tyrosine protein kinase Lyn 0.0065 0.1221 0.1816
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0063 0.1166 0.1734
Echinococcus multilocularis tyrosine protein kinase HCK 0.005 0.0732 0.1085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0911 0.1352
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0059 0.105 0.1559
Schistosoma mansoni roundabout 0.0046 0.0601 0.0601
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0059 0.105 0.1045
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0911 0.1352
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0059 0.105 0.1559
Brugia malayi protein-tyrosine kinase 0.0056 0.0952 0.0947
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0503 0.0497
Echinococcus granulosus G1Y162 protein 0.0059 0.105 0.1559
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0059 0.105 0.1559
Onchocerca volvulus 0.0043 0.0503 0.1975
Brugia malayi SRC-1 0.0063 0.1166 0.1162
Schistosoma mansoni titin 0.0059 0.105 0.105
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0048 0.0684 0.1013
Loa Loa (eye worm) TK/ROR protein kinase 0.0064 0.1204 0.1199
Schistosoma mansoni protein tyrosine phosphatase 0.0059 0.105 0.105
Echinococcus multilocularis tyrosine protein kinase Srms 0.0056 0.0952 0.1414
Brugia malayi Prion-like- 0.0046 0.0601 0.0596
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0778 0.0101
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0778 1
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0778 0.1154
Echinococcus multilocularis titin 0.0059 0.105 0.1559
Onchocerca volvulus Putative titin 0.0043 0.0503 0.1975
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.1685 0.2508
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0105 0.2567 0.2562
Loa Loa (eye worm) TK/ABL protein kinase 0.023 0.6701 0.6699
Schistosoma mansoni septate junction protein 0.0046 0.0601 0.0601
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0601 0.0596
Brugia malayi Immunoglobulin I-set domain containing protein 0.0105 0.2567 0.2562
Onchocerca volvulus 0.0059 0.105 0.4147
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.105 1
Onchocerca volvulus 0.0043 0.0503 0.1975
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0056 0.0952 0.1414
Leishmania major hypothetical protein, conserved 0.0059 0.105 1
Schistosoma mansoni tyrosine kinase 0.0057 0.0984 0.0984
Echinococcus multilocularis insulin growth factor binding 0.0043 0.0503 0.0743
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Schistosoma mansoni tyrosine kinase 0.0063 0.1166 0.1166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0911 0.0911
Loa Loa (eye worm) projectin 0.0102 0.2468 0.2464
Schistosoma mansoni nephrin 0.0105 0.2567 0.2567
Brugia malayi Lethal protein 805 0.0059 0.105 0.1045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0102 0.2468 0.2464
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0911 0.0911
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0059 0.105 1
Schistosoma mansoni tyrosine kinase 0.0028 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0059 0.105 0.105
Schistosoma mansoni cell adhesion molecule 0.0102 0.2468 0.2468
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Echinococcus granulosus roundabout 2 0.0114 0.2869 0.4276
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.1685 0.2508
Echinococcus granulosus lachesin 0.0046 0.0601 0.089
Onchocerca volvulus 0.0059 0.105 0.4147
Loa Loa (eye worm) TK protein kinase 0.0056 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.0055 0.0903 0.0898
Echinococcus multilocularis Fibronectin, type III 0.0059 0.105 0.1559
Echinococcus granulosus titin 0.0043 0.0503 0.0743
Schistosoma mansoni tyrosine kinase 0.0149 0.4002 0.4002
Echinococcus granulosus tyrosine protein kinase ABL1 0.023 0.6701 1
Schistosoma mansoni tyrosine kinase 0.0079 0.1685 0.1685
Schistosoma mansoni tyrosine kinase 0.0079 0.1685 0.1685
Echinococcus multilocularis cell adhesion molecule 0.0059 0.105 0.1559
Loa Loa (eye worm) hypothetical protein 0.0069 0.1352 0.1347
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Loa Loa (eye worm) disorganized muscle protein 1 0.0043 0.0503 0.0497
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.2468 0.2464
Echinococcus granulosus down syndrome cell adhesion 0.0043 0.0503 0.0743
Loa Loa (eye worm) hypothetical protein 0.0059 0.105 0.1045
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0048 0.0684 0.1013
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0046 0.0601 0.0596
Entamoeba histolytica protein kinase, putative 0.0048 0.0684 0.9337
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0952 0.1414
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0059 0.105 0.105
Schistosoma mansoni cell adhesion molecule 0.0105 0.2567 0.2567
Echinococcus multilocularis anosmin 1 0.0059 0.105 0.1559
Onchocerca volvulus 0.0059 0.105 0.4147
Loa Loa (eye worm) SRC-1 0.0063 0.1166 0.1162
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0558 0.0558
Schistosoma mansoni titin 0.0043 0.0503 0.0503
Onchocerca volvulus 0.0059 0.105 0.4147
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0503 0.0497
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.0497
Onchocerca volvulus 0.0043 0.0503 0.1975
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0064 0.1204 0.179
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.322 0.3216
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0105 0.2567 0.3825

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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