TDR Targets

Basic information

Technical information

TDR Targets ID: 1452843
Name: 4-[(1S)-2-(4-bromophenyl)sulfanyl-1-phenyleth yl]-1-(2-methylpropyl)-1,4-diazepan-5-one
MW: 461.458 | Formula: C23H29BrN2OS
H donors: 0 H acceptors: 1 LogP: 5.23 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(CN1CCN(C(=O)CC1)[C@@H](c1ccccc1)CSc1ccc(cc1)Br)C
InChi: 1S/C23H29BrN2OS/c1-18(2)16-25-13-12-23(27)26(15-14-25)22(19-6-4-3-5-7-19)17-28-21-10-8-20(24)9-11-21/h3-11,18,22H,12-17H2,1-2H3/t22-/m1/s1
InChiKey: IEABHKNILNTSFJ-JOCHJYFZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(1S)-2-(4-bromophenyl)sulfanyl-1-phenyl-ethyl]-1-isobutyl-1,4-diazepan-5-one
4-[(1S)-2-[(4-bromophenyl)thio]-1-phenylethyl]-1-isobutyl-1,4-diazepan-5-one
4-[(1S)-2-[(4-bromophenyl)thio]-1-phenyl-ethyl]-1-isobutyl-1,4-diazepan-5-one
4-[(1S)-2-(4-bromophenyl)sulfanyl-1-phenyl-ethyl]-1-(2-methylpropyl)-1,4-diazepan-5-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Schistosoma mansoni	Thioredoxin glutathione reductase	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium yoelii	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Cryptosporidium hominis	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium knowlesi	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium berghei	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei gambiense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Neospora caninum	Glutathione reductase, related	Get druggable targets OG5_126785	All targets in OG5_126785
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania donovani	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania mexicana	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Trypanosoma cruzi	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Babesia bovis	thiodoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Toxoplasma gondii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Cryptosporidium parvum	thioredoxin reductase 1	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	Thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	MGC84926 protein, related	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Theileria parva	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium berghei	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	538 aa	25.3 %
Plasmodium knowlesi	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	518 aa	22.0 %
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	521 aa	21.5 %
Plasmodium yoelii	dihydrolipoamide dehydrogenase	Thioredoxin glutathione reductase	598 aa	537 aa	24.2 %
Onchocerca volvulus		Thioredoxin glutathione reductase	598 aa	533 aa	50.8 %
Neospora caninum	Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related	Thioredoxin glutathione reductase	598 aa	512 aa	28.3 %
Neospora caninum	hypothetical protein	Thioredoxin glutathione reductase	598 aa	485 aa	30.5 %
Neospora caninum	glutathione reductase, putative	Thioredoxin glutathione reductase	598 aa	532 aa	34.6 %
Toxoplasma gondii	NADPH-glutathione reductase	Thioredoxin glutathione reductase	598 aa	555 aa	33.5 %
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	Thioredoxin glutathione reductase	598 aa	513 aa	25.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	protein farnesyltransferase, putative	0.024	0.0619	0.241
Brugia malayi	N-terminal motif family protein	0.0197	0.0499	0.0496
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.024	0.0619	0.0615
Schistosoma mansoni	hypothetical protein	0.0171	0.0425	0.0425
Plasmodium falciparum	glutathione reductase	0.0035	0.0046	0.0042
Schistosoma mansoni	eyes absent homolog	0.0096	0.0217	0.0217
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0035	0.0046	0.0042
Onchocerca volvulus		0.0035	0.0045	0.005
Echinococcus multilocularis	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0008
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0933	0.2554	1
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0079	0.0075
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0052	0.0052
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0058	0.0058
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0029	0.0028	0.534
Schistosoma mansoni	lipoxygenase	0.0478	0.1283	0.1283
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0022	0.0011	0.0011
Brugia malayi	PHD-finger family protein	0.0027	0.0024	0.002
Entamoeba histolytica	hypothetical protein	0.0022	0.001	0.0006
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0017	0.0017
Toxoplasma gondii	thioredoxin reductase	0.0101	0.023	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0024	0.0024
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0081	0.0173	0.0169
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.003	0.003
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0056	0.0104	0.0391
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0058	0.0054
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0052	0.0052
Entamoeba histolytica	hypothetical protein	0.0043	0.007	0.0066
Schistosoma mansoni	hypothetical protein	0.0047	0.0079	0.0079
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0065	0.013	0.013
Schistosoma mansoni	kinase	0.0058	0.0112	0.0112
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0052	0.0052
Echinococcus granulosus	lysosome membrane protein 2	0.1213	0.3338	0.3338
Mycobacterium tuberculosis	Probable reductase	0.023	0.0591	0.891
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0065	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.1213	0.3338	0.3338
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0035	0.0046	0.0165
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0028	0.534
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0933	0.2554	0.2554
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0065	0.013	0.0126
Echinococcus granulosus	lysosomal alpha glucosidase	0.0177	0.0442	0.0442
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0022	0.001	0.0022
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.023	0.0591	0.891
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0104	0.01
Echinococcus granulosus	Protein patched homolog 1	0.0048	0.0084	0.0084
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0079	0.0079
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0058	0.0058
Trypanosoma brucei	lanosterol synthase	0.0065	0.013	0.0495
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0065	0.013	0.0126
Echinococcus multilocularis	snurportin 1	0.0289	0.0755	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0035	0.0046	0.0165
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0058	0.0054
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0933	0.2554	1
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.3598	1	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0035	0.0046	0.0165
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0035	0.0046	0.5
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0029	0.0028	0.534
Brugia malayi	MAP kinase sur-1	0.0056	0.0104	0.01
Schistosoma mansoni	carbonic anhydrase-related	0.0081	0.0173	0.0173
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0115	0.0268	0.0265
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.007	0.007
Echinococcus granulosus	carbonic anhydrase	0.0081	0.0173	0.0173
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.2665	0.7394	0.7393
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.024	0.0619	0.0832
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.024	0.0619	0.0619
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.3598	1	1
Echinococcus granulosus	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Trichomonas vaginalis	esterase, putative	0.0035	0.0045	0.0041
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0268	0.0265
Loa Loa (eye worm)	transcription factor SMAD2	0.026	0.0674	0.0674
Trypanosoma cruzi	hypothetical protein, conserved	0.0933	0.2554	1
Leishmania major	trypanothione reductase	0.0101	0.023	0.0887
Echinococcus granulosus	carbonic anhydrase	0.0081	0.0173	0.0173
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0056	0.0104	0.0391
Echinococcus multilocularis	lamin	0.0029	0.003	0.003
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0104	0.01
Trypanosoma cruzi	polo-like protein kinase, putative	0.0115	0.0268	0.1037
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0177	0.0442	0.0438
Echinococcus multilocularis	zinc finger protein	0.0021	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0047	0.0079	0.0079
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0933	0.2554	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.023	0.0591	0.891
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0052	0.0048
Plasmodium vivax	multidomain scavenger receptor, putative	0.0171	0.0425	0.0421
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0058	0.0211
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0045	0.0261
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0148	0.0362	0.0362
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0081	0.0173	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0197	0.0499	0.0499
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0028	0.0024
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0115	0.0268	0.0268
Echinococcus granulosus	snurportin 1	0.0289	0.0755	0.0755
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0933	0.2554	0.2551
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0478	0.1283	0.1283
Plasmodium falciparum	glutathione reductase	0.0101	0.023	0.0226
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.013	0.0495
Loa Loa (eye worm)	carbonic anhydrase 3	0.0171	0.0427	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0217	0.0217
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0008	0.005
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0171	0.0427	0.0427
Onchocerca volvulus		0.0029	0.003	0.0005
Echinococcus multilocularis	expressed conserved protein	0.0106	0.0244	0.0244
Trypanosoma cruzi	lanosterol synthase, putative	0.0065	0.013	0.0495
Schistosoma mansoni	carbonic anhydrase-related	0.0081	0.0173	0.0173
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0065	0.013	0.0126
Schistosoma mansoni	hypothetical protein	0.0025	0.0018	0.0018
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.3598	1	1
Echinococcus multilocularis	carbonic anhydrase	0.0081	0.0173	0.0173
Entamoeba histolytica	acyl-coA synthetase, putative	0.0029	0.0028	0.0024
Echinococcus granulosus	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Plasmodium falciparum	ataxin-2 like protein, putative	0.0055	0.0103	0.0099
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0035	0.0046	0.0046
Loa Loa (eye worm)	MH2 domain-containing protein	0.026	0.0674	0.0674
Trypanosoma cruzi	trypanothione reductase, putative	0.0035	0.0046	0.0165
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0115	0.0268	0.1037
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0052	0.0052
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.3598	1	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0008	0.0004
Trichomonas vaginalis	importin beta-1, putative	0.0022	0.001	0.0006
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0933	0.2554	0.2551
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0058	0.0058
Echinococcus granulosus	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Brugia malayi	beta-lactamase family protein	0.0035	0.0045	0.0041
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0065	0.0129	0.0129
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0065	0.013	0.0126
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0197	0.0499	0.1423
Trypanosoma cruzi	PAB1-binding protein , putative	0.0055	0.0103	0.0388
Schistosoma mansoni	polycystin 1-related	0.0171	0.0425	0.0425
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0057	0.0057
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0081	0.0173	0.0169
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0058	0.0054
Plasmodium falciparum	importin beta, putative	0.0027	0.0024	0.002
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0148	0.0362	0.0359
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0045	0.0609
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.002	0.0004	0.0004
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.2276	0.2276
Trypanosoma brucei	hypothetical protein, conserved	0.0933	0.2554	1
Schistosoma mansoni	lipoxygenase	0.0171	0.0425	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0425	0.0425
Plasmodium vivax	ataxin-2 like protein, putative	0.0055	0.0103	0.0099
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0028	0.0024
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0058	0.0073
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0045	0.0609
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0028	0.534
Trypanosoma cruzi	polo-like protein kinase, putative	0.0115	0.0268	0.1037
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0052	0.0052
Mycobacterium ulcerans	hypothetical protein	0.0029	0.0028	0.534
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0052	0.019
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0081	0.0173	0.0169
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0058	0.0054
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0035	0.0046	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.3598	1	1
Leishmania major	hypothetical protein, conserved	0.0035	0.0045	0.0161
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0256	0.0663	1
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0065	0.013	0.0126
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0028	0.0024
Toxoplasma gondii	ABC1 family protein	0.0035	0.0045	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0028
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0025	0.0018	0.0018
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0029	0.0028	0.0357
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0171	0.0427	0.166
Toxoplasma gondii	hypothetical protein	0.2665	0.7394	1
Brugia malayi	Doublecortin family protein	0.0171	0.0425	0.0421
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0268	0.0265
Leishmania major	importin beta-1 subunit, putative	0.0022	0.001	0.0022
Trypanosoma brucei	polo-like protein kinase	0.0115	0.0268	0.1037
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0104	0.01
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0081	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.0081	0.0173	0.0173
Trypanosoma brucei	importin beta-1 subunit, putative	0.0027	0.0024	0.0078
Schistosoma mansoni	hypothetical protein	0.0188	0.0473	0.0473
Echinococcus multilocularis	sterol regulatory element binding protein	0.0048	0.0084	0.0084
Toxoplasma gondii	LsmAD domain-containing protein	0.0055	0.0103	0.0134
Echinococcus multilocularis	RUN	0.0171	0.0425	0.0425
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0115	0.0268	0.0268
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0256	0.0663	1
Trypanosoma cruzi	lanosterol synthase, putative	0.0065	0.013	0.0495
Mycobacterium tuberculosis	Probable dehydrogenase	0.023	0.0591	0.891
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0065	0.013	0.0126
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0079	0.0079
Giardia lamblia	Rab geranylgeranyltransferase	0.3598	1	1
Brugia malayi	hypothetical protein	0.0043	0.007	0.0066
Schistosoma mansoni	hypothetical protein	0.0289	0.0755	0.0755
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0289	0.0755	0.0755
Trypanosoma brucei	protein kinase, putative	0.0056	0.0104	0.0391
Echinococcus multilocularis	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0256	0.0663	1
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0933	0.2554	1
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.024	0.0619	0.241
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0177	0.0442	0.0442
Brugia malayi	CHE-14 protein	0.0048	0.0084	0.008
Onchocerca volvulus		0.0102	0.0234	0.062
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0057	0.0057
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0065	0.013	0.013
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.0442	0.0442
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0056	0.0104	0.0104
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0171	0.0427	0.0427
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.024	0.0619	0.0615
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0035	0.0046	0.0165
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0268	0.0265
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0933	0.2554	0.2551
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0058	0.0054
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0065	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.1213	0.3338	0.3338
Echinococcus granulosus	GTP binding nuclear protein Ran	0.002	0.0004	0.0004
Toxoplasma gondii	NADPH-glutathione reductase	0.0035	0.0046	0.0057
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0035	0.0046	0.0165
Echinococcus granulosus	zinc finger protein	0.0021	0.0008	0.0008
Echinococcus granulosus	carbonic anhydrase II	0.0171	0.0427	0.0427
Schistosoma mansoni	carbonic anhydrase	0.0081	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.0047	0.0079	0.0079
Schistosoma mansoni	hypothetical protein	0.0101	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Echinococcus multilocularis	Niemann Pick C1 protein	0.0161	0.0399	0.0399
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0058	0.0054
Brugia malayi	glutathione reductase	0.0101	0.023	0.0226
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0045	0.0045
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0045	0.0041
Leishmania major	farnesyltransferase beta subunit	0.024	0.0619	0.241
Onchocerca volvulus	Lysosome membrane protein 2 homolog	0.1213	0.3338	1
Loa Loa (eye worm)	glutathione reductase	0.0101	0.023	0.023
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.003	0.0026
Echinococcus granulosus	lamin	0.0029	0.003	0.003
Echinococcus multilocularis	importin subunit beta 1	0.0027	0.0024	0.0024
Echinococcus granulosus	mitogen activated protein kinase	0.0056	0.0104	0.0104
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.0108	0.0104
Schistosoma mansoni	cd36 antigen	0.0458	0.1229	0.1229
Schistosoma mansoni	CD36-like class B scavenger receptor	0.1213	0.3338	0.3338
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0028
Echinococcus multilocularis	carbonic anhydrase II	0.0171	0.0427	0.0427
Mycobacterium ulcerans	lipase LipD	0.0035	0.0045	0.9717
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0028	0.0096
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.024	0.0619	0.0615
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0056	0.0104	0.0391
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0058	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0065	0.0065
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0029	0.0028	0.0024
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0933	0.2554	0.2554
Echinococcus multilocularis	lysosome membrane protein 2	0.1213	0.3338	0.3338
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0115	0.0268	0.0268
Brugia malayi	hypothetical protein	0.0458	0.1229	0.1225
Trichomonas vaginalis	glutathione reductase, putative	0.0035	0.0046	0.0042
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.0108	0.0104
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0221	0.0565	0.8518
Brugia malayi	CD36 family protein	0.1213	0.3338	0.3336
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0078	0.0078
Brugia malayi	Bromodomain containing protein	0.0042	0.0064	0.006
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0045	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0028
Leishmania major	hypothetical protein, conserved	0.0055	0.0103	0.0388
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0171	0.0427	0.0424
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0045	0.0161
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.3598	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0081	0.0173	0.0169
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0035	0.0046	0.0042
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.002	0.0004	0.0004
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.3598	1	1
Onchocerca volvulus		0.0035	0.0045	0.005
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0035	0.0046	0.0165
Echinococcus multilocularis	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.003	0.003
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0035	0.0046	0.0165
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0933	0.2554	0.2554
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0058	0.0054
Echinococcus multilocularis	geminin	0.0188	0.0473	0.0473
Schistosoma mansoni	hypothetical protein	0.0047	0.0079	0.0079
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0171	0.0425	0.0425
Echinococcus granulosus	intermediate filament protein	0.0029	0.003	0.003
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0028	0.0096
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0478	0.1283	0.1283
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.3598	1	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0035	0.0046	0.0625
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0079	0.0079
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0045	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0052	0.0048
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.024	0.0619	0.0615
Brugia malayi	Thioredoxin reductase	0.0101	0.023	0.0226
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0035	0.0046	0.0057
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0045	0.0041
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0035	0.0046	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0045	0.0261
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0079	0.0079
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0045	0.0161
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.024	0.0619	0.0619
Brugia malayi	Importin beta-1 subunit	0.0027	0.0024	0.002
Plasmodium falciparum	thioredoxin reductase	0.0035	0.0046	0.0042
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0029	0.0028	0.0357
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0022	0.001	0.0006
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0035	0.0046	0.0042
Schistosoma mansoni	zinc finger protein	0.0021	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0173	0.0173
Entamoeba histolytica	hypothetical protein	0.0043	0.007	0.0066
Schistosoma mansoni	patched 1	0.0048	0.0084	0.0084
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0045	0.9717
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.024	0.0619	0.0615
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0065	0.013	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0114	0.0114
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0933	0.2554	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0933	0.2554	0.2554
Schistosoma mansoni	carbonic anhydrase-related	0.0081	0.0173	0.0173
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0056	0.0104	0.0104
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0065	0.013	0.0171
Brugia malayi	latrophilin 2 splice variant baaae	0.0101	0.0231	0.0228
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.3598	1	1
Echinococcus multilocularis	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.2276	0.2276
Echinococcus granulosus	geminin	0.0188	0.0473	0.0473
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0058	0.0211
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0933	0.2554	0.2551
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0933	0.2554	0.2554
Brugia malayi	Niemann-Pick C1 protein precursor	0.0113	0.0263	0.026
Trypanosoma brucei	PAB1-binding protein , putative	0.0055	0.0103	0.0388
Schistosoma mansoni	intermediate filament proteins	0.0029	0.003	0.003
Onchocerca volvulus		0.0171	0.0425	0.1198
Trypanosoma cruzi	protein farnesyltransferase, putative	0.024	0.0619	0.241
Onchocerca volvulus		0.0171	0.0425	0.1198
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0035	0.0046	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0029	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0362	0.0362
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.2276	0.2276
Onchocerca volvulus		0.0029	0.003	0.0005
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0002	0.0002
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0104	0.0104
Schistosoma mansoni	lamin	0.0029	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1229	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0263	0.0263
Loa Loa (eye worm)	thioredoxin reductase	0.0101	0.023	0.023
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.3598	1	1
Entamoeba histolytica	hypothetical protein	0.0043	0.007	0.0066
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0048	0.0084	0.0084
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0017	0.0017
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.024	0.0619	0.0615
Echinococcus multilocularis	carbonic anhydrase	0.0081	0.0173	0.0173
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0017	0.0017
Trypanosoma brucei	importin beta-1 subunit, putative	0.0027	0.0024	0.0078
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0045	0.0609
Echinococcus granulosus	importin subunit beta 1	0.0027	0.0024	0.0024
Echinococcus multilocularis	mitogen activated protein kinase	0.0056	0.0104	0.0104
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0268	0.0265
Giardia lamblia	Prenyltransferase	0.024	0.0619	0.0615
Brugia malayi	serine/threonine-protein kinase plk-2	0.0115	0.0268	0.0265
Echinococcus multilocularis	lamin dm0	0.0029	0.003	0.003
Trypanosoma brucei	trypanothione reductase	0.0101	0.023	0.0887
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0035	0.0046	0.0165
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0026	0.002	0.0016
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0052	0.019
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0052	0.0052
Echinococcus granulosus	sterol regulatory element binding protein	0.0048	0.0084	0.0084
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0268	0.0265
Giardia lamblia	Kinase, PLK	0.0115	0.0268	0.0265
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0035	0.0046	0.5
Trichomonas vaginalis	mercuric reductase, putative	0.0035	0.0046	0.0042
Echinococcus granulosus	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Schistosoma mansoni	lamin	0.0029	0.003	0.003
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.0058	0.0054
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0058	0.0054
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0025	0.0018	0.0018
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0268	0.0265
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0029	0.0028	0.534
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0045	0.0609
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0035	0.0046	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0035	0.0046	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0173	0.0173
Treponema pallidum	NADH oxidase	0.0035	0.0046	0.5
Brugia malayi	RNA, U transporter 1	0.0077	0.0163	0.0159
Leishmania major	carbonic anhydrase-like protein	0.0171	0.0427	0.166
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0035	0.0046	0.0042
Brugia malayi	hypothetical protein	0.0458	0.1229	0.1225
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0115	0.0268	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Schistosoma mansoni	scavenger receptor class B type-2 (sr-B2)	0.1213	0.3338	0.3338
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0058	0.0211
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0268	0.0265
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0045	0.0609
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.013	0.0495
Schistosoma mansoni	hypothetical protein	0.0047	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0173	0.0173
Plasmodium vivax	glutathione reductase, putative	0.0101	0.023	0.0226
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.024	0.0619	0.0615
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.007	0.007
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0045	0.0045
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0028	0.534
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.023	0.0591	0.891
Echinococcus granulosus	mitogen activated protein kinase 3	0.0056	0.0104	0.0104
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0084	0.008
Echinococcus granulosus	expressed conserved protein	0.0106	0.0244	0.0244
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0045	0.0045
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0065	0.013	0.013
Giardia lamblia	Rab geranylgeranyltransferase	0.0933	0.2554	0.2551
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.024	0.0619	0.0615
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0026	0.002	0.0016
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0079	0.0079
Echinococcus granulosus	lamin dm0	0.0029	0.003	0.003
Echinococcus granulosus	Polycystic kidney disease protein	0.0171	0.0425	0.0425
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0104	0.01
Toxoplasma gondii	HEAT repeat-containing protein	0.0027	0.0024	0.0027
Brugia malayi	hypothetical protein	0.0171	0.0425	0.0421
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0052	0.0048
Echinococcus granulosus	Niemann Pick C1 protein	0.0113	0.0263	0.0263
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0175	0.0437	0.0433
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0933	0.2554	0.2551
Schistosoma mansoni	rab6-interacting	0.0171	0.0425	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0217	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0008
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0035	0.0046	0.0165
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.023	0.0591	0.887
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0171	0.0427	0.166
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0065	0.013	0.0495
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0028	0.0096
Trypanosoma cruzi	trypanothione reductase, putative	0.0101	0.023	0.0887
Echinococcus multilocularis	carbonic anhydrase	0.0081	0.0173	0.0173
Leishmania major	geranylgeranyltransferase, putative	0.0065	0.013	0.0495
Echinococcus granulosus	lipoxygenase domain containing protein	0.0171	0.0425	0.0425
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0035	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0052	0.0052
Echinococcus multilocularis	protein patched	0.0048	0.0084	0.0084
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0052	0.019
Schistosoma mansoni	alpha glucosidase	0.0039	0.0058	0.0058
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0052	0.019
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.024	0.0619	0.0615
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0045	0.9717
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0045	0.0609
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0171	0.0427	0.0427
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0035	0.0046	0.0165
Schistosoma mansoni	hypothetical protein	0.0047	0.0079	0.0079
Echinococcus granulosus	thioredoxin glutathione reductase	0.0101	0.0232	0.0232
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.024	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.1213	0.3338	0.3338
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0148	0.0362	0.0359
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0056	0.0104	0.0135
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0045	0.9717
Echinococcus granulosus	RUN	0.0171	0.0425	0.0425
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0022	0.001	0.0006
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0045	0.0045
Schistosoma mansoni	alpha-glucosidase	0.0152	0.0373	0.0373
Schistosoma mansoni	alpha-glucosidase	0.0152	0.0373	0.0373
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0045	0.9717
Echinococcus multilocularis	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0079	0.0079
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0079	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0008
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.0268	0.0268
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0045	0.0609
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.0442	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0065	0.013	0.013
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0113	0.0263	0.026
Plasmodium falciparum	carbonic anhydrase	0.0081	0.0173	0.0169
Echinococcus granulosus	GPCR family 2	0.0047	0.0079	0.0079
Plasmodium falciparum	thioredoxin reductase	0.0101	0.023	0.0226
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0035	0.0046	0.0165
Plasmodium falciparum	ataxin-2 like protein, putative	0.0055	0.0103	0.0099
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0029	0.0028	0.0024
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.0104	0.0391
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0058	0.0054
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0065	0.013	0.1905
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0035	0.0046	0.0042
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0035	0.0046	0.0165
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0045	0.0609
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0065	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0072	0.0072
Brugia malayi	hypothetical protein	0.0036	0.0048	0.0044
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0045	0.0041
Echinococcus granulosus	Niemann Pick C1 protein	0.0161	0.0399	0.0399
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0035	0.0046	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0163	0.0163
Schistosoma mansoni	hypothetical protein	0.0047	0.0079	0.0079
Plasmodium vivax	thioredoxin reductase, putative	0.0101	0.023	0.0226
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0045	0.0041
Echinococcus multilocularis	Niemann Pick C1 protein	0.0113	0.0263	0.0263
Plasmodium vivax	geranylgeranyltransferase, putative	0.0065	0.013	0.0126
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0045	0.0045
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0052	0.0048
Loa Loa (eye worm)	doublecortin family protein	0.0171	0.0425	0.0425
Onchocerca volvulus		0.0933	0.2554	0.7632
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.2684	0.2684
Brugia malayi	MH2 domain containing protein	0.026	0.0674	0.0671
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.024	0.0619	0.0619
Schistosoma mansoni	ran	0.002	0.0004	0.0004
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0933	0.2554	1
Schistosoma mansoni	hypothetical protein	0.0188	0.0473	0.0473
Brugia malayi	Bromodomain containing protein	0.0081	0.0175	0.0172
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0171	0.0427	0.0424
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0056	0.0104	0.0391
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.024	0.0619	0.0615
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0045	0.0045
Toxoplasma gondii	hypothetical protein	0.0081	0.0173	0.0229
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.0104	0.0391
Giardia lamblia	Kinase, CMGC MAPK	0.0056	0.0104	0.01
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0052	0.0048
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0035	0.0046	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0084	0.0084
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0045	0.0041
Toxoplasma gondii	hypothetical protein	0.0933	0.2554	0.3451
Giardia lamblia	Rab geranylgeranyltransferase	0.0065	0.013	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0008
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0065	0.013	0.0171
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0171	0.0425	0.0425
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0933	0.2554	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0055	0.0103	0.0388
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0045	0.0041
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0933	0.2554	0.2554
Echinococcus granulosus	lipoxygenase domain containing protein	0.0171	0.0425	0.0425
Schistosoma mansoni	importin beta-1	0.0027	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0052	0.0052
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0065	0.013	0.0126
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.0058	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1229	0.1229
Brugia malayi	hypothetical protein	0.0096	0.0217	0.0213
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0065	0.013	0.0126
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0035	0.0046	1
Trypanosoma brucei	carbonic anhydrase-like protein	0.0171	0.0427	0.166
Mycobacterium tuberculosis	Probable oxidoreductase	0.0256	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0425	0.0425
Echinococcus multilocularis	musashi	0.0029	0.003	0.003
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0065	0.013	0.0495
Echinococcus granulosus	CD36 class B scavenger receptor	0.1213	0.3338	0.3338
Schistosoma mansoni	bromodomain containing protein	0.0069	0.014	0.014
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0065	0.013	0.013
Echinococcus multilocularis	Polycystic kidney disease protein	0.0171	0.0425	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0008
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0045	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1229	0.1229
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0035	0.0046	0.0046
Schistosoma mansoni	CD36-like class B scavenger receptor	0.1213	0.3338	0.3338
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0065	0.013	0.0126
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0101	0.023	0.3424
Brugia malayi	beta-lactamase family protein	0.0035	0.0045	0.0041
Schistosoma mansoni	rab6-interacting	0.0171	0.0425	0.0425
Schistosoma mansoni	ran	0.002	0.0004	0.0004
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0029	0.0028	0.534
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0101	0.0232	0.0232
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.023	0.0591	0.891
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0052	0.0048
Brugia malayi	hypothetical protein	0.0055	0.0103	0.0099
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0115	0.0268	0.0268
Brugia malayi	hypothetical protein	0.0171	0.0425	0.0421
Schistosoma mansoni	hypothetical protein	0.0047	0.0079	0.0079
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0065	0.013	0.013
Echinococcus multilocularis	protein dispatched 1	0.0055	0.0103	0.0103
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0011	0.0011
Entamoeba histolytica	hypothetical protein	0.0043	0.007	0.0066
Trypanosoma cruzi	hypothetical protein, conserved	0.0933	0.2554	1
Onchocerca volvulus		0.0035	0.0045	0.005
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0079	0.0079
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.007	0.007
Plasmodium falciparum	LCCL domain-containing protein	0.0171	0.0425	0.0421
Loa Loa (eye worm)	hypothetical protein	0.3598	1	1
Plasmodium vivax	importin-beta 2, putative	0.0027	0.0024	0.002
Brugia malayi	beta-lactamase	0.0035	0.0045	0.0041
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0035	0.0046	0.0165
Brugia malayi	intermediate filament protein	0.0029	0.003	0.0026
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0056	0.0104	0.0391
Trypanosoma brucei	glucosidase, putative	0.0039	0.0058	0.0211
Echinococcus granulosus	carbonic anhydrase	0.0081	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.0043	0.007	0.007
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0008	0.0004
Schistosoma mansoni	loxhd1	0.0171	0.0425	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0065	0.013	0.013
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0045	0.0609

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	2.8184 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	13.3714 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	16.3535 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	26.8545 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1585280

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1452843