Detailed information for compound 1453779

Basic information

Technical information
  • TDR Targets ID: 1453779
  • Name: N-(3,4-dimethoxyphenyl)-1,8-dimethyl-4H-thioc hromeno[3,4-d]pyrazole-3-carboxamide
  • MW: 395.475 | Formula: C21H21N3O3S
  • H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)NC(=O)c1nn(c2c1CSc1c2cc(cc1)C)C
  • InChi: 1S/C21H21N3O3S/c1-12-5-8-18-14(9-12)20-15(11-28-18)19(23-24(20)2)21(25)22-13-6-7-16(26-3)17(10-13)27-4/h5-10H,11H2,1-4H3,(H,22,25)
  • InChiKey: MPAGSLFSGAVRRB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • G541-0404
  • NCGC00131822-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens galactosylceramidase No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.0827 0.1902
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0102 0.0127
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0474 0.1052
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0036 0.0338
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0102 0.014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0019 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0237 0.0227
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0293 0.0658
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.42 0.9762
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Trichomonas vaginalis chromobox protein, putative 0.007 0.028 0.0628
Schistosoma mansoni hypothetical protein 0.0028 0.0077 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Echinococcus multilocularis solute carrier family 22 0.0015 0.0011 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0027 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.0113
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0166 0.0747 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0027 0.0025
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.047 0.0986
Echinococcus granulosus expressed protein 0.0034 0.0102 0.01
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0027 0.0025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0121 0.0153
Mycobacterium ulcerans phosphoglycerate kinase 0.0166 0.0747 0.102
Mycobacterium ulcerans hypothetical protein 0.0073 0.0293 0.0391
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0235 0.3048
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0027 0.0025
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0237 0.3077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.0113
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0099 0.1191
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0019 0.0019
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0117 0.0115
Plasmodium falciparum glutathione reductase 0.0048 0.0171 0.2181
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0099 0.1191
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0428 0.202 0.2785
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0067 0.0759
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0474 0.1079
Echinococcus multilocularis solute carrier family 22 0.0015 0.0011 0.0009
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.0458 0.2268
Brugia malayi Phosphoglycerate kinase 0.0061 0.0235 0.114
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.0827 0.1902
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0102 0.0506
Schistosoma mansoni coup transcription factor 0.0018 0.0027 0.0016
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0235 0.3048
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0392 0.039
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0015 0.0059
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0036 0.0338
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0037 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0125 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0212 0.2738
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0121 0.0237
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0019 0.0068
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0293 0.0606
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0106 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0074 0.0148
Trypanosoma brucei unspecified product 0.0037 0.0118 0.1457
Echinococcus granulosus flap endonuclease 1 0.0026 0.0067 0.0064
Schistosoma mansoni rotamase 0.0034 0.0102 0.0092
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0144 0.1813
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0474 0.1079
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0125 0.1557
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0971 0.4665 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0134
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0019 0.0113
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.2219 0.2217
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.013 0.0519
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0261
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.0199 0.0197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0027 0.0016
Leishmania major DNA polymerase eta, putative 0.0079 0.0324 0.4253
Echinococcus granulosus dna polymerase kappa 0.008 0.0329 0.0327
Brugia malayi major facilitator superfamily protein 0.0015 0.0011 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.013 0.0278
Schistosoma mansoni chromobox protein 0.007 0.028 0.027
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0176 0.087
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0117 0.1442
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0036 0.0058
Schistosoma mansoni lamin 0.0027 0.0071 0.006
Mycobacterium ulcerans lipase LipD 0.0073 0.0293 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0027 0.0107
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0529 0.1113
Mycobacterium tuberculosis Conserved protein 0.0073 0.0293 0.0606
Onchocerca volvulus 0.0031 0.0089 0.0339
Brugia malayi steroid hormone receptor 0.0018 0.0027 0.0107
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0474 0.1052
Schistosoma mansoni chromobox protein 0.007 0.028 0.027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.42 0.9762
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0027 0.0025
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0027 0.0025
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.0199 0.0188
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0027 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0151 0.1897
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0293 0.3836
Trichomonas vaginalis rotamase, putative 0.0034 0.0102 0.0213
Toxoplasma gondii ABC1 family protein 0.0073 0.0293 0.3836
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0077 0.0315 0.0599
Echinococcus multilocularis bloom syndrome protein 0.002 0.0036 0.0033
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0036 0.0033
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0145 0.0312
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0185
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0324 0.4253
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0144 0.1813
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0114 0.0496 0.0672
Brugia malayi Pre-SET motif family protein 0.0061 0.0237 0.115
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0117 0.1442
Leishmania major pyruvate kinase 0.0034 0.0102 0.1241
Chlamydia trachomatis transglycolase/transpeptidase 0.0741 0.3545 0.4233
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.0113
Leishmania major small ubiquitin protein, putative 0.003 0.0084 0.0996
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Brugia malayi hypothetical protein 0.0015 0.0011 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0027 0.0134
Trichomonas vaginalis DNA polymerase eta, putative 0.008 0.0329 0.0742
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0134
Brugia malayi jmjC domain containing protein 0.0093 0.0392 0.1917
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0102 0.0506
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0231 0.0473
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0037 0.0057
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0023 0.0158
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0773 0.3703 0.7921
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0132 0.058 0.7732
Trypanosoma brucei unspecified product 0.0074 0.0297 0.3888
Chlamydia trachomatis pyruvate kinase 0.0034 0.0102 0.01
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0023 0.0158
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0474 0.0472
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0019 0.0113
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0102 0.0507
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0145 0.0312
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0009 0.0047
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0019 0.0115
Brugia malayi nuclear hormone receptor 0.0018 0.0027 0.0107
Echinococcus multilocularis pyruvate kinase 0.0034 0.0102 0.01
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0132 0.058 0.0578
Echinococcus granulosus solute carrier family 22 0.0015 0.0011 0.0009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0117 0.1442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0027 0.0134
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0117 0.0106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0117 0.0579
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0171 0.0169
Leishmania major cytochrome p450-like protein 0.0016 0.0015 0.0059
Plasmodium falciparum glutathione reductase 0.0017 0.0019 0.0113
Schistosoma mansoni transcription factor btf3 0.0038 0.0125 0.0115
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0027 0.0016
Leishmania major hypothetical protein, conserved 0.0073 0.0293 0.3836
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0036 0.0177
Plasmodium falciparum thioredoxin reductase 0.0048 0.0171 0.2181
Loa Loa (eye worm) SMO-1 protein 0.003 0.0084 0.0417
Echinococcus multilocularis geminin 0.0357 0.1676 0.1674
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.0113
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0117 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0117 0.0247
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0212 0.2738
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0084 0.0996
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.0747 0.1715
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.145
Leishmania major DNA polymerase kappa, putative 0.006 0.0231 0.2995
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0224 0.111
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0474 0.1079
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0132 0.058 0.2849
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.2219 0.2217
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0036 0.015
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0114 0.0496 0.0494
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0293 0.0291
Echinococcus multilocularis pyruvate kinase 0.0017 0.0023 0.002
Leishmania major phosphoglycerate kinase B, cytosolic 0.0166 0.0747 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0023 0.002
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0083 0.0982
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0235 0.3048
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0011 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0027 0.0134
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0474 0.0463
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0117 0.0115
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0284 0.1321 0.2815
Onchocerca volvulus 0.0487 0.2309 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0293 0.145
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.008 0.0329 0.0742
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0171 0.0169
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0102 0.1241
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0293 0.0291
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0439
Mycobacterium ulcerans endonuclease IV 0.0077 0.0315 0.0421
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0027 0.0025
Plasmodium falciparum pyruvate kinase 0.0034 0.0102 0.1241
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.0644
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0102 0.0397
Onchocerca volvulus 0.0073 0.0293 0.1228
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0084 0.0996
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0117 0.0115
Plasmodium vivax SET domain protein, putative 0.0061 0.0237 0.3077
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0102 0.0481
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0125 0.0621
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0019 0.0115
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0036 0.0033
Leishmania major hypothetical protein, conserved 0.0056 0.0212 0.2738
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0074 0.0148
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0134
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0145 0.0582
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0019 0.0113
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0293 0.0606
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.145
Echinococcus granulosus solute carrier family 22 0.0015 0.0011 0.0009
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0161 0.0723 0.1481
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0083 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.42 0.9762
Toxoplasma gondii exonuclease III APE 0.0038 0.0121 0.15
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0329 0.0441
Toxoplasma gondii endonuclease IV APN 0.0077 0.0315 0.4127
Loa Loa (eye worm) hypothetical protein 0.0034 0.0102 0.0506
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0474 0.0546
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0083 0.0168
Leishmania major phosphoglycerate kinase C, glycosomal 0.0166 0.0747 1
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0293 0.0606
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0015 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0102 0.0213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0027 0.0025
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0011 0.0009
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0011 0.0027
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.0084 0.0082
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0083 0.0172
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0083 0.0982
Brugia malayi beta-lactamase 0.0073 0.0293 0.1427
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0071 0.0324
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0067 0.0331
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0329 0.4328
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0099 0.1191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.42 0.9762
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0077 0.0898
Schistosoma mansoni ap endonuclease 0.0038 0.0121 0.011
Schistosoma mansoni ap endonuclease 0.0038 0.0121 0.011
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0102 0.1241
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0324 0.1579
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0315 0.4127
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0134
Plasmodium falciparum thioredoxin reductase 0.0017 0.0019 0.0113
Plasmodium vivax glutathione reductase, putative 0.0048 0.0171 0.2181
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0117 0.0195
Echinococcus multilocularis pyruvate kinase 0.0017 0.0023 0.002
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0117 0.0253
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0027 0.0016
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.058 0.7732
Schistosoma mansoni DNA polymerase eta 0.0079 0.0324 0.0313
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0381
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0293 0.0658
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0106 0.0095
Brugia malayi Flap endonuclease-1 0.0026 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0134
Echinococcus multilocularis solute carrier family 22 0.0015 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Onchocerca volvulus 0.0073 0.0293 0.1228
Brugia malayi Heterochromatin protein 1 0.007 0.028 0.1364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0027 0.0134
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0474 0.1052
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0083 0.0077
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0027 0.0025
Onchocerca volvulus 0.0073 0.0293 0.1228
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.058 0.7732
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0474 0.0463
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0235 0.3048
Brugia malayi Bromodomain containing protein 0.0028 0.0077 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0027 0.0107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0117 0.0553
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0293 0.0391
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0177
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0397 0.187 0.3959
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0027 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Mycobacterium leprae Probable lipase LipE 0.0073 0.0293 0.0553
Brugia malayi phosphofructokinase 0.011 0.0474 0.2323
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0067 0.0133
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0474 0.0642
Loa Loa (eye worm) hypothetical protein 0.0077 0.0315 0.1556
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0117 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0212 0.2738
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0474 0.0943
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0077 0.0898
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0015 0.0076
Brugia malayi Pre-SET motif family protein 0.0428 0.2022 1
Chlamydia trachomatis phosphoglycerate kinase 0.0166 0.0747 0.0874
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0067 0.0074
Brugia malayi ecdysteroid receptor 0.0018 0.0027 0.0107
Leishmania major DNA polymerase eta, putative 0.0042 0.0144 0.1813
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0106 0.0095
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.1174
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0023 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0027 0.0107
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0171 0.2181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0027 0.0134
Echinococcus granulosus transcription factor Dp 1 0.0076 0.031 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0231 0.2995
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0132 0.058 0.0578
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0027 0.0025
Brugia malayi PHD-finger family protein 0.0028 0.0077 0.0355
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0083 0.0077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0121 0.15
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.0827 0.1902
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0027 0.0107
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0235 0.3048
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Treponema pallidum penicillin-binding protein (pbp-1) 0.1727 0.8347 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0293 0.0658
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0619 0.2952 0.6297
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0293 0.3836
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.0199 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0237 0.0227
Trichomonas vaginalis set domain proteins, putative 0.0487 0.2309 0.5356
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0306
Schistosoma mansoni hypothetical protein 0.0357 0.1676 0.1667
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0027 0.0025
Trypanosoma brucei unspecified product 0.0037 0.0118 0.1457
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0166 0.0747 0.0883
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0293 0.0658
Leishmania major basic transcription factor 3a, putative 0.0038 0.0125 0.1557
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0171 0.0345
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0011 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0084 0.0171
Giardia lamblia PHD finger protein 15 0.0028 0.0077 0.0158
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0083 0.0982
Echinococcus granulosus bloom syndrome protein 0.002 0.0036 0.0033
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0036 0.0338
Echinococcus granulosus pyruvate kinase 0.0034 0.0102 0.01
Treponema pallidum hypothetical protein 0.0161 0.0723 0.0845
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0067 0.0759
Echinococcus multilocularis solute carrier family 22 0.0015 0.0011 0.0009
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.0084 0.0996
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0102 0.0213
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0083 0.0982
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0099 0.1191
Brugia malayi polk-prov protein 0.0043 0.015 0.0716
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0161 0.0723 0.1529
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0293 0.1427
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0019 0.0113
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0083 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0121 0.0257
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0971 0.4665 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0102 0.0397
Loa Loa (eye worm) hypothetical protein 0.0043 0.015 0.0741
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0182 0.0827 0.4074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0027 0.0134
Echinococcus granulosus peregrin 0.0028 0.0077 0.0075
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0011 0.0009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.047 0.0986
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0083 0.0168
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0232 0.0229
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0329 0.4328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0027 0.0107
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0027 0.0025
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0019 0.0113
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0067 0.0064
Echinococcus granulosus phosphoglycerate kinase 1 0.0166 0.0747 0.0745
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0053 0.0261
Mycobacterium tuberculosis Conserved protein 0.0073 0.0293 0.0606
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0067 0.0759
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0106 0.0104
Brugia malayi Sugar transporter family protein 0.0015 0.0011 0.0027
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0121 0.0263
Giardia lamblia Pyruvate kinase 0.0017 0.0023 0.0028
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1497 0.7226 1
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0053 0.0041
Leishmania major trypanothione reductase 0.0048 0.0171 0.2181
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0027 0.0016
Echinococcus granulosus pyruvate kinase 0.0017 0.0023 0.002
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0019 0.0115
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0315 0.4127
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0293 0.0606
Plasmodium falciparum phosphoglycerate kinase 0.0166 0.0747 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0232 0.0221
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0077 0.0381
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0083 0.0168
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0019 0.0115
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0036 0.0058
Echinococcus granulosus pyruvate kinase 0.0017 0.0023 0.002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.0113
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0329 0.4328
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0182 0.0827 0.1948
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0102 0.0196
Echinococcus multilocularis lamin dm0 0.0027 0.0071 0.0068
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0474 0.2344
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0019 0.002
Leishmania major DNA damage repair protein, putative 0.0017 0.0019 0.0115
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0132 0.058 0.1307
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.0199 0.0197
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.0084 0.0073
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0027 0.0107
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0474 0.6291
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0121 0.15
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0011 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0019 0.0115
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0182 0.0827 0.1131
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0182 0.0827 0.409
Chlamydia trachomatis endonuclease IV 0.0077 0.0315 0.0355
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0114 0.0496 0.0494
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0019 0.0115
Onchocerca volvulus 0.0027 0.0071 0.0261
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0027 0.0025
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.047 0.0986
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0027 0.0107
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0077 0.0898
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0117 0.0247
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0019 0.0113
Treponema pallidum phosphoglycerate kinase 0.0166 0.0747 0.0874
Treponema pallidum fructose-bisphosphate aldolase 0.0875 0.42 0.502
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0232 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0027 0.0107
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0232 0.0474
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0293 0.0283
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0077 0.0066
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0077 0.0075
Brugia malayi Sugar transporter family protein 0.0015 0.0011 0.0027
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0067 0.013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0875 0.42 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0019 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0015 0.0059
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.0084 0.0996
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0102 0.0213
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0166 0.0747 0.1581
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0121 0.0257
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0329 0.4328
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0293 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.015 0.1888
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0083 0.0982
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0299 0.0288
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.047 0.0986
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0027 0.0107
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0019 0.0113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0027 0.0134
Brugia malayi hypothetical protein 0.0015 0.0011 0.0027
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0019 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0083 0.0168
Echinococcus granulosus pyruvate kinase 0.0034 0.0102 0.01
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0036 0.0338
Echinococcus granulosus chromobox protein 1 0.007 0.028 0.0278
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0036 0.0338
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0773 0.3703 0.7933
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0011 0.0009
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0011 0.0027
Schistosoma mansoni hypothetical protein 0.0357 0.1676 0.1667
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0125 0.1557
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.0827 0.1902
Entamoeba histolytica hypothetical protein 0.0038 0.0125 0.0215
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0114 0.0496 0.6591
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0151 0.1897
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0015 0.0011 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0027 0.0107
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0102 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0027 0.0107
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0106 0.0104
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0619 0.2952 0.4076
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0019 0.0115
Onchocerca volvulus Alhambra homolog 0.0028 0.0077 0.0288
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0019 0.0113
Brugia malayi jmjC domain containing protein 0.0034 0.0106 0.0499
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0008
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0036 0.0058
Treponema pallidum penicillin-binding protein (pbp-3) 0.1658 0.801 0.9596
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0102 0.1241
Onchocerca volvulus 0.0073 0.0293 0.1228
Chlamydia trachomatis transglycolase/transpeptidase 0.1727 0.8347 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0083 0.0168
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0019 0.001
Brugia malayi 6-phosphofructokinase 0.011 0.0474 0.2323
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0102 0.0506
Echinococcus multilocularis pyruvate kinase 0.0027 0.0068 0.0065
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0199 0.0404
Mycobacterium ulcerans epimerase 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0121 0.0123
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0027 0.0107
Brugia malayi chromobox protein homolog 3 0.0039 0.013 0.0618
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.0747 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0102 0.1241
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0529 0.1113
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.42 0.9762
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0037 0.0037
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0019 0.0115
Giardia lamblia Fructose-bisphosphate aldolase 0.0875 0.42 1
Mycobacterium ulcerans DNA polymerase IV 0.008 0.0329 0.0441
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0121 0.06
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0121 0.0119
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0182 0.0827 0.19
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0077 0.0075
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0226 0.0224
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0132 0.058 0.057
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0474 0.1079
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0027 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0896 0.4302 1
Plasmodium falciparum phd finger protein, putative 0.0028 0.0077 0.0898
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0015 0.0006
Schistosoma mansoni flap endonuclease-1 0.0024 0.0054 0.0044
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0017
Brugia malayi major facilitator superfamily protein 0.0015 0.0011 0.0027
Echinococcus granulosus lamin 0.0027 0.0071 0.0068
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0071 0.0351
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.0084 0.0996
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0019 0.0113
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1727 0.8347 1
Schistosoma mansoni pyruvate kinase 0.0034 0.0102 0.0091
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.0747 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.028 0.0628
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0027 0.007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0121 0.0119
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0102 0.1241
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0117 0.0115
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0011 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0027 0.0107
Loa Loa (eye worm) beta-lactamase 0.0073 0.0293 0.145
Echinococcus multilocularis musashi 0.0027 0.0071 0.0068
Echinococcus multilocularis dna polymerase kappa 0.008 0.0329 0.0327
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0125 0.1557
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0339
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0125 0.1557
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0019 0.0019
Echinococcus multilocularis pyruvate kinase 0.0034 0.0102 0.01
Brugia malayi Thioredoxin reductase 0.0048 0.0171 0.0823
Loa Loa (eye worm) hypothetical protein 0.0027 0.0071 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.047 0.0934
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.0827 0.1902
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.0827 0.1902
Plasmodium falciparum flap endonuclease 1 0.0026 0.0067 0.0759
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Schistosoma mansoni pyruvate kinase 0.0034 0.0102 0.0091
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0036 0.0059
Giardia lamblia Phosphoglycerate kinase 0.0166 0.0747 0.1757
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.047 0.0986
Echinococcus granulosus pyruvate kinase 0.0017 0.0023 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0102 0.1241
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Echinococcus multilocularis chromobox protein 1 0.007 0.028 0.0278
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0114 0.0496 0.0486
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0199 0.096
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0474 0.0472
Toxoplasma gondii thioredoxin reductase 0.0048 0.0171 0.2181
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0121 0.0205
Trypanosoma brucei DNA polymerase IV, putative 0.0074 0.0297 0.3888
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.0747 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0428 0.202 0.4317
Loa Loa (eye worm) sugar transporter 0.0015 0.0011 0.0054
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0011 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.42 0.9762
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.0747 1
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.0747 0.0737
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.0199 0.0392
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0121 0.15
Plasmodium vivax phosphoglycerate kinase, putative 0.0166 0.0747 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0009 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0237 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.013 0.0278
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0896 0.4302 0.9214
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0235 0.3048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0027 0.0107
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0027 0.0025
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.058 0.7732
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0329 0.4328
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0166 0.0747 0.1533
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0019 0.0115
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0019 0.0113
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0171 0.2181
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0114 0.0496 0.0672
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0027 0.0025
Brugia malayi glutathione reductase 0.0048 0.0171 0.0823
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0019 0.0115
Echinococcus granulosus solute carrier family 22 0.0015 0.0011 0.0009
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0474 0.2344
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0067 0.0759
Brugia malayi beta-lactamase family protein 0.0073 0.0293 0.1427
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.145
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0011 0.0009
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0036 0.0033
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0077 0.0315 0.1533
Trypanosoma brucei DNA polymerase eta, putative 0.0079 0.0324 0.4253
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0212 0.047
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0392 0.039
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.0199 0.0984
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0011 0.0054
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0182 0.0827 0.19
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0293 0.0606
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0019 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0293 0.0283
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0011 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0465 0.2204 0.4712
Brugia malayi Phosphoglycerate kinase 0.0166 0.0747 0.3677
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0114 0.0496 0.1042
Echinococcus granulosus dna polymerase eta 0.0079 0.0324 0.0322
Echinococcus granulosus intermediate filament protein 0.0027 0.0071 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0329 0.4328
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.145
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0125 0.0215
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0083 0.0168
Echinococcus granulosus neuropeptide s receptor 0.0468 0.2219 0.2217
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0126 0.0553 0.1165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0121 0.15
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0474 0.0995
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.015 0.1888
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0474 0.6291
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0019 0.0113
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0036 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0293 0.3836
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0231 0.2995
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.2219 0.2217
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0293 0.0283
Brugia malayi hypothetical protein 0.0015 0.0011 0.0027
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0083 0.0982
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0232 0.2999
Loa Loa (eye worm) hypothetical protein 0.0079 0.0324 0.1602
Loa Loa (eye worm) hypothetical protein 0.0166 0.0747 0.3694
Mycobacterium ulcerans hypothetical protein 0.002 0.0037 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0329 0.4328
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0099 0.0151
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0027 0.0025
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0161 0.0723 0.0987
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0166 0.0747 1
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0971 0.4665 0.6451
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0875 0.42 1
Mycobacterium tuberculosis Probable reductase 0.0109 0.047 0.0986
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0121 0.0132
Mycobacterium tuberculosis Conserved protein 0.0073 0.0293 0.0606
Brugia malayi Cytochrome P450 family protein 0.0016 0.0015 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0121 0.15
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0171 0.0848
Echinococcus multilocularis chromobox protein 1 0.007 0.028 0.0278
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.0496 0.2433
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0232 0.2999
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0134
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.42 0.9762
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.0084 0.0082
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0397 0.187 0.3994
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0125 0.1557
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0037 0.0115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0134
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0117 0.0115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Schistosoma mansoni microtubule-associated protein tau 0.2067 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0036 0.0338
Giardia lamblia Sentrin 0.003 0.0084 0.0175
Echinococcus multilocularis phosphoglycerate kinase 1 0.0166 0.0747 0.0745
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0054
Schistosoma mansoni pyruvate kinase 0.0017 0.0023 0.0012
Leishmania major pyruvate kinase 0.0034 0.0102 0.1241
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0077 0.0315 0.0652
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0027 0.0025
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0773 0.3703 0.5118
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0027 0.0016
Loa Loa (eye worm) glutathione reductase 0.0048 0.0171 0.0848
Echinococcus multilocularis peregrin 0.0028 0.0077 0.0075
Echinococcus granulosus Solute carrier family 22 5 0.1047 0.5036 0.5035
Brugia malayi Sugar transporter family protein 0.0015 0.0011 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0293 0.0553
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0237 0.0227
Mycobacterium ulcerans hypothetical protein 0.0017 0.0019 0.0012
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0067 0.0759
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0015 0.0076
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0237 0.0235
Trichomonas vaginalis esterase, putative 0.0073 0.0293 0.0658
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.0084 0.0391
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.031 0.0307
Trichomonas vaginalis rotamase, putative 0.0033 0.0099 0.0204
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0019 0.0018
Loa Loa (eye worm) phosphofructokinase 0.011 0.0474 0.2344
Mycobacterium ulcerans beta-lactamase 0.0073 0.0293 0.0391
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0036 0.0033
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0235 0.3048
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0232 0.0229
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0125 0.0267
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0019 0.0008
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0125 0.1557
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0011 0.0009
Echinococcus granulosus jumonji domain containing protein 0.004 0.0131 0.0129
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0036 0.015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0117 0.0247
Echinococcus multilocularis transcription factor btf3 0.0038 0.0125 0.0123
Brugia malayi beta-lactamase family protein 0.0073 0.0293 0.1427
Onchocerca volvulus 0.0027 0.0071 0.0261
Echinococcus granulosus lamin dm0 0.0027 0.0071 0.0068
Giardia lamblia DINP protein human, muc B family 0.006 0.0231 0.0526
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0027 0.007
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0293 0.0391
Leishmania major DNA polymerase kappa, putative 0.0017 0.0019 0.0115
Echinococcus multilocularis lamin 0.0027 0.0071 0.0068
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0036 0.0338
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0052 0.0555
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0015 0.0059
Brugia malayi intermediate filament protein 0.0027 0.0071 0.0324
Brugia malayi Cytochrome P450 family protein 0.0016 0.0015 0.0049
Loa Loa (eye worm) RecQ helicase 0.002 0.0036 0.0177
Onchocerca volvulus 0.0182 0.0827 0.355
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0117 0.1442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0027 0.0134
Schistosoma mansoni lamin 0.0027 0.0071 0.006
Onchocerca volvulus 0.0018 0.0027 0.007
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0121 0.0574
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0113
Echinococcus granulosus transcription factor btf3 0.0038 0.0125 0.0123
Brugia malayi nuclear receptor NHR-88 0.0018 0.0027 0.0107
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0102 0.048
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0619 0.2952 0.6318
Schistosoma mansoni DNA helicase recq5 0.002 0.0036 0.0025
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.2022 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0151 0.1897
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0083 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0027 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0293 0.3836
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.0084 0.0996
Brugia malayi 6-phosphofructokinase 0.011 0.0474 0.2323
Echinococcus granulosus solute carrier family 22 0.0015 0.0011 0.0009
Entamoeba histolytica phosphoglycerate kinase, putative 0.0166 0.0747 0.1707
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.0747 0.1715
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0529 0.1113
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0293 0.0658
Echinococcus multilocularis dna polymerase eta 0.0079 0.0324 0.0322
Brugia malayi beta-NAC-like protein 0.0038 0.0125 0.0595
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0293 0.0606
Treponema pallidum penicillin-binding protein (pbp-2) 0.0896 0.4302 0.5143
Giardia lamblia Pyruvate kinase 0.0034 0.0102 0.0218
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0019 0.0115
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0212 0.047
Schistosoma mansoni intermediate filament proteins 0.0027 0.0071 0.006
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0102 0.048
Giardia lamblia DNA damage repair protein 0.0017 0.0019 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0019 0.0113
Loa Loa (eye worm) sugar transporter 0.0015 0.0011 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0125 0.0267
Echinococcus granulosus geminin 0.0357 0.1676 0.1674
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0027 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.2067 1 1
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.0747 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0027 0.0107
Entamoeba histolytica ubiquitin like protein 0.003 0.0084 0.0116
Echinococcus multilocularis expressed protein 0.0034 0.0102 0.01
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0235 0.3048
Echinococcus granulosus chromobox protein 1 0.007 0.028 0.0278
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0131 0.0129
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0121 0.15
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0306
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0027 0.0016
Trypanosoma brucei trypanothione reductase 0.0048 0.0171 0.2181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.0113
Schistosoma mansoni DNA helicase recq1 0.002 0.0036 0.0025
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0132 0.058 0.2869
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0474 0.6291
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0428 0.202 0.4284
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.028 0.1387
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0011 0.0009
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0071 0.0351
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0099 0.1191
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0896 0.4302 0.5947
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0019 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0237 0.0235
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0083 0.0982
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.42 0.9762
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0529 0.1062

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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