Detailed information for compound 1455700

Basic information

Technical information
  • TDR Targets ID: 1455700
  • Name: 1-hydroxy-2-(4-methoxyphenyl)imidazo[4,5-b]py ridine
  • MW: 241.245 | Formula: C13H11N3O2
  • H donors: 1 H acceptors: 3 LogP: 2.41 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nc2c(n1O)cccn2
  • InChi: 1S/C13H11N3O2/c1-18-10-6-4-9(5-7-10)13-15-12-11(16(13)17)3-2-8-14-12/h2-8,17H,1H3
  • InChiKey: NBUJWRNZNAECII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8F-310S
  • ZINC01400186
  • Oprea1_846057

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.011 0.0174 0.0174
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0109 0.0108
Wolbachia endosymbiont of Brugia malayi recombinase A 0.011 0.0175 0.2353
Loa Loa (eye worm) Ulp1 protease 0.0068 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0007 0.088
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.0057 0.057
Echinococcus granulosus muscleblind protein 0.0306 0.0523 0.0521
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0034 0.5328
Schistosoma mansoni ap endonuclease 0.0023 0.0019 0.0017
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0395 0.0683 1
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0027 0.024
Onchocerca volvulus 0.0027 0.0026 0.1298
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0002 0.0059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0201 0.0337 0.0337
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Brugia malayi Importin beta-1 subunit 0.0035 0.004 0.004
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0056 0.052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0026 0.0026
Schistosoma mansoni peroxidasin 0.0027 0.0026 0.0024
Onchocerca volvulus 0.0028 0.0027 0.1359
Echinococcus granulosus lamin dm0 0.0028 0.0027 0.0026
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0026 0.0026
Loa Loa (eye worm) beta-lactamase 0.0037 0.0044 0.0044
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0044 0.006
Treponema pallidum fructose-bisphosphate aldolase 0.0598 0.1043 1
Schistosoma mansoni hypothetical protein 0.0083 0.0127 0.0125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0037 0.0044 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.1043 1
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0002 0.0059
Brugia malayi Doublecortin family protein 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0306 0.0523 0.0523
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0044 0.1489
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.0099 0.0936
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.004
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0034 0.1672
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0027 0.0027
Brugia malayi beta-lactamase family protein 0.0037 0.0044 0.0044
Onchocerca volvulus 0.0037 0.0044 0.2177
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0019 0.1741
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0242 0.0242
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.5624 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0292 0.0499 0.7228
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0039 0.0356
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0019 0.0635
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0049 0.1679
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0598 0.1043 1
Echinococcus multilocularis lamin dm0 0.0028 0.0027 0.0026
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0056 0.0054
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0062 0.6153
Echinococcus granulosus transcription factor eb 0.011 0.0175 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.1043 1
Mycobacterium leprae Conserved hypothetical protein 0.1166 0.2055 1
Mycobacterium ulcerans recombinase A 0.011 0.0175 0.2353
Schistosoma mansoni smad1 5 8 and 0.0017 0.0008 0.0006
Loa Loa (eye worm) endoplasmin 0.0047 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0125 0.0202 0.0202
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.004 0.6427
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0007 0.0238
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0347 0.0596 0.0594
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0044 0.0057 0.0063
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.0099 0.0099
Schistosoma mansoni cpg binding protein 0.0029 0.0031 0.0029
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0026 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0094 0.0092
Schistosoma mansoni hypothetical protein 0.0372 0.0641 0.0639
Schistosoma mansoni hypothetical protein 0.0083 0.0127 0.0125
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Mycobacterium ulcerans lipase LipD 0.0037 0.0044 0.0379
Trypanosoma brucei heat shock protein, putative 0.0047 0.0062 1
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Plasmodium vivax sentrin-specific protease 2, putative 0.0013 0.0002 0.0059
Brugia malayi hypothetical protein 0.0074 0.0109 0.0109
Loa Loa (eye worm) acetyltransferase 0.0148 0.0242 0.0242
Echinococcus granulosus geminin 0.0347 0.0596 0.0594
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.0057 0.9145
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0044 0.0404
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.0337 0.0335
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0069 0.0069
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0035 0.1713
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0057 0.0526
Trichomonas vaginalis Sentrin-specific protease, putative 0.0068 0.0099 0.0936
Brugia malayi hypothetical protein 0.0017 0.0008 0.0008
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0062 0.2095
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0007 0.0238
Brugia malayi beta-lactamase 0.0037 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0044 0.4322
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0057 0.0526
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1659 0.2934 0.2932
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0005
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0034 0.3278
Echinococcus multilocularis tumor protein p63 0.0408 0.0705 0.0704
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0019 0.0019
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Onchocerca volvulus Huntingtin homolog 0.0125 0.0202 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0005
Schistosoma mansoni hypothetical protein 0.5624 1 1
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0026 0.0026
Onchocerca volvulus 0.0027 0.0026 0.1298
Loa Loa (eye worm) hypothetical protein 0.0306 0.0523 0.0523
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.1043 1
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0044 0.0042
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0044 0.006
Schistosoma mansoni hypothetical protein 0.0074 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0035
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0085 0.0083
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Trypanosoma brucei heat shock protein, putative 0.0047 0.0062 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.0012
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.0337 0.0335
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.0413 0.0413
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0089 0.0087
Echinococcus granulosus heat shock protein 0.0047 0.0062 0.006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Leishmania major heat shock protein, putative 0.0031 0.0034 0.5328
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0024 0.23
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0026 0.1298
Schistosoma mansoni endoplasmin 0.0047 0.0062 0.006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0002 0.0059
Brugia malayi Peroxidasin 0.0027 0.0026 0.0026
Echinococcus multilocularis heat shock protein 90 0.004 0.005 0.0048
Echinococcus multilocularis RUN 0.002 0.0014 0.0012
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0026 0.1298
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.0044
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.5624 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.0012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.0193 0.0192
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0017 0.0008 0.0008
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.1043 1
Brugia malayi RNA binding protein 0.0065 0.0094 0.0094
Plasmodium vivax endoplasmin, putative 0.0047 0.0062 0.2095
Trypanosoma cruzi DNA repair protein, putative 0.0034 0.0039 0.3801
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0062 0.0576
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.005 0.046
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0049 0.0458
Echinococcus granulosus caspase 2 0.0032 0.0035 0.0033
Echinococcus multilocularis sentrin specific protease 8 0.0068 0.0099 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0109 0.0108
Schistosoma mansoni cpg binding protein 0.0031 0.0034 0.0032
Trypanosoma brucei heat shock protein, putative 0.0047 0.0062 1
Schistosoma mansoni lipoxygenase 0.0121 0.0193 0.0192
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0044 0.006
Schistosoma mansoni patched 1 0.0086 0.0132 0.0131
Mycobacterium tuberculosis Conserved protein 0.0037 0.0044 0.006
Echinococcus granulosus microtubule associated protein 2 0.0706 0.1236 0.1235
Echinococcus multilocularis musashi 0.0028 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0125 0.0202 0.0202
Entamoeba histolytica hypothetical protein 0.0028 0.0029 0.0257
Brugia malayi hypothetical protein 0.0032 0.0035 0.0035
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0235 0.0233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.1043 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.0193 0.0192
Schistosoma mansoni hypothetical protein 0.0347 0.0596 0.0594
Loa Loa (eye worm) twinkle helicase 0.0113 0.018 0.018
Echinococcus granulosus cpg binding protein 0.0031 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0068 0.0099 0.0097
Schistosoma mansoni hypothetical protein 0.0032 0.0035 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0044 0.7025
Entamoeba histolytica hypothetical protein 0.0074 0.0109 0.1033
Schistosoma mansoni heat shock protein 0.0047 0.0062 0.006
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0084 0.2846
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.011 0.0175 0.0652
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0292 0.0499 0.2261
Schistosoma mansoni Replicative DNA helicase 0.0395 0.0683 0.0681
Toxoplasma gondii ABC1 family protein 0.0037 0.0044 0.1489
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0012
Echinococcus granulosus smad 0.0017 0.0008 0.0006
Onchocerca volvulus 0.006 0.0085 0.42
Echinococcus granulosus heat shock protein 90 0.004 0.005 0.0048
Brugia malayi CXXC zinc finger family protein 0.0029 0.0031 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0005
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0062 1
Onchocerca volvulus Peroxidase homolog 0.0027 0.0026 0.1298
Giardia lamblia Grp94/Hsp90 0.0044 0.0057 0.0526
Loa Loa (eye worm) hypothetical protein 0.011 0.0174 0.0174
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0008 0.0008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0019 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.1043 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0056 0.1899
Onchocerca volvulus 0.0013 0.0002 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0007 0.0005
Plasmodium falciparum importin beta, putative 0.0035 0.004 0.1367
Plasmodium vivax importin-beta 2, putative 0.0035 0.004 0.1367
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.0723 0.0722
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0242 0.0241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0007 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0024 0.23
Loa Loa (eye worm) hypothetical protein 0.0051 0.0069 0.0069
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0132 0.0131
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0034 0.0039 0.6178
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.0343 0.0341
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0005
Schistosoma mansoni peroxidasin 0.0027 0.0026 0.0024
Schistosoma mansoni hypothetical protein 0.0418 0.0723 0.0722
Schistosoma mansoni endoplasmin 0.0047 0.0062 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.1043 1
Schistosoma mansoni hypothetical protein 0.0083 0.0127 0.0125
Schistosoma mansoni importin beta-1 0.0035 0.004 0.0039
Plasmodium vivax heat shock protein, putative 0.0178 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Echinococcus granulosus intermediate filament protein 0.0028 0.0027 0.0026
Schistosoma mansoni intermediate filament proteins 0.0028 0.0027 0.0026
Echinococcus multilocularis apoptotic protease activating factor 1 0.0032 0.0035 0.0033
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.0012
Plasmodium vivax sentrin-specific protease 1, putative 0.0013 0.0002 0.0059
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0099 0.0936
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0007 0.0542
Loa Loa (eye worm) doublecortin family protein 0.002 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.5624 1 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0056 0.052
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3467 0.6156 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0019 0.0635
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0007
Onchocerca volvulus 0.002 0.0014 0.0704
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0395 0.0683 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0019 0.2829
Onchocerca volvulus 0.0027 0.0026 0.1298
Brugia malayi Hsp90 protein 0.0031 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0074 0.0109 0.1033
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.0398 0.0635
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0069 0.0069
Echinococcus multilocularis GPCR, family 2 0.0016 0.0007 0.0005
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0005
Echinococcus granulosus expressed conserved protein 0.0189 0.0315 0.0314
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0019 0.0163
Onchocerca volvulus 0.0029 0.0031 0.1516
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.1236 0.1235
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0026 0.0026
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0008 0.0006
Brugia malayi RNA, U transporter 1 0.0099 0.0155 0.0155
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0062 0.2095
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0024 0.082
Schistosoma mansoni smad1 5 8 and 0.0017 0.0008 0.0006
Brugia malayi Smad1 0.0017 0.0008 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0031 0.0031
Schistosoma mansoni Smad4 0.0017 0.0008 0.0006
Toxoplasma gondii exonuclease III APE 0.0023 0.0019 0.0635
Echinococcus multilocularis protein dispatched 1 0.0099 0.0154 0.0152
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.088
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Brugia malayi MH1 domain containing protein 0.0017 0.0008 0.0008
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0034 0.1144
Echinococcus multilocularis endoplasmin 0.0044 0.0057 0.0055
Brugia malayi intermediate filament protein 0.0028 0.0027 0.0027
Chlamydia trachomatis recombinase RecA 0.011 0.0175 0.2544
Leishmania major hypothetical protein, conserved 0.0026 0.0024 0.3738
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0044 0.006
Echinococcus granulosus snurportin 1 0.0372 0.0641 0.0639
Brugia malayi Muscleblind-like protein 0.0306 0.0523 0.0523
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0044 0.006
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0035 0.0033
Trichomonas vaginalis heat shock protein, putative 0.004 0.005 0.046
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.5624 1 1
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Treponema pallidum replicative DNA helicase (dnaB) 0.0395 0.0683 0.6479
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0044 0.0042
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.0337 0.0337
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0109 0.0108
Echinococcus multilocularis Niemann Pick C1 protein 0.0288 0.0491 0.0489
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.0413 0.0413
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0027 0.0909
Brugia malayi TAR-binding protein 0.0065 0.0094 0.0094
Onchocerca volvulus 0.0032 0.0035 0.1713
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0005
Echinococcus multilocularis protein patched 0.0086 0.0132 0.0131
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0094 0.0092
Plasmodium falciparum sentrin-specific protease 1 0.0013 0.0002 0.0059
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0014 0.0012
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.0337 0.3219
Trypanosoma brucei heat shock protein, putative 0.0047 0.0062 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0238
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.004 0.1367
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0007 0.0007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0242 0.0241
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0062 1
Brugia malayi Endoplasmin precursor 0.0047 0.0062 0.0062
Echinococcus multilocularis cpg binding protein 0.0031 0.0034 0.0032
Echinococcus granulosus lamin 0.0028 0.0027 0.0026
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3182 0.5648 0.9174
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0019 0.0017
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.005 0.4916
Echinococcus multilocularis transcription factor eb 0.011 0.0175 0.0173
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0062 0.0062
Echinococcus multilocularis importin subunit beta 1 0.0035 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0086 0.0132 0.0132
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0062 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.0012
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Echinococcus granulosus GPCR family 2 0.0016 0.0007 0.0005
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0026 0.0026
Brugia malayi Blistered cuticle protein 3 0.0027 0.0026 0.0026
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0034 0.0032
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0062 0.2095
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0062 0.6153
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0019 0.0019
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0026 0.1298
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0026 0.1298
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0008 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0598 0.1043 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0005
Trypanosoma brucei heat shock protein, putative 0.0047 0.0062 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Echinococcus multilocularis smad 0.0017 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0005
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.005 0.4916
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0007 0.0005
Brugia malayi hypothetical protein 0.0026 0.0024 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0044 0.0379
Echinococcus granulosus Smad4 0.0017 0.0008 0.0006
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0094 0.0094
Toxoplasma gondii Hsp90 domain-containing protein 0.0178 0.0295 1
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0012
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0026 0.0026
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0008 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.0598 0.1043 1
Trypanosoma brucei heat shock protein, putative 0.0047 0.0062 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0167 0.0167
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.0044
Mycobacterium ulcerans beta-lactamase 0.0037 0.0044 0.0379
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0056 0.1899
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0027
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0007 0.0005
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0005 0.0005
Schistosoma mansoni lipoxygenase 0.0084 0.0129 0.0127
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.004
Schistosoma mansoni cpg binding protein 0.0031 0.0034 0.0032
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Onchocerca volvulus 0.0037 0.0044 0.2177
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0014 0.0012
Treponema pallidum recombinase A 0.011 0.0175 0.1525
Schistosoma mansoni lamin 0.0028 0.0027 0.0026
Echinococcus multilocularis geminin 0.0347 0.0596 0.0594
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.088
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0039 0.0356
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0094 0.0092
Loa Loa (eye worm) RNA binding protein 0.0065 0.0094 0.0094
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0099 0.0936
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.0057 0.0081
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0062 0.0576
Echinococcus multilocularis muscleblind protein 1 0.0306 0.0523 0.0521
Mycobacterium ulcerans heat shock protein 90 0.0044 0.0057 0.057
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0024 0.082
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0094 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0044 0.0042
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0132 0.1253
Brugia malayi heat shock protein 90 0.0047 0.0062 0.0062
Mycobacterium tuberculosis Conserved protein 0.0037 0.0044 0.006
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0094 0.0094
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0007
Brugia malayi beta-lactamase family protein 0.0037 0.0044 0.0044
Onchocerca volvulus Peroxidase homolog 0.0027 0.0026 0.1298
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0026 0.0026
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0026 0.0026
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0132 0.0132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0019 0.1741
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0019 0.0163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0029 0.0257
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0019 0.2829
Trypanosoma cruzi hypothetical protein 0.0068 0.0099 1
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0062 0.6153
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0132 0.0131
Echinococcus granulosus tumor protein p63 0.0408 0.0705 0.0704
Trypanosoma brucei heat shock protein, putative 0.0047 0.0062 1
Schistosoma mansoni loxhd1 0.002 0.0014 0.0012
Echinococcus granulosus importin subunit beta 1 0.0035 0.004 0.0039
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0062 0.0576
Echinococcus multilocularis heat shock protein 0.0047 0.0062 0.006
Trypanosoma brucei heat shock protein, putative 0.0047 0.0062 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0008 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0019 0.0163
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0395 0.0683 0.3176
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Onchocerca volvulus 0.0028 0.0027 0.1359
Entamoeba histolytica hypothetical protein 0.0074 0.0109 0.1033
Onchocerca volvulus 0.0037 0.0044 0.2177
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0024
Schistosoma mansoni lamin 0.0028 0.0027 0.0026
Plasmodium falciparum heat shock protein 90 0.0047 0.0062 0.2095
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0044 0.0044
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0019 0.0019
Echinococcus granulosus endoplasmin 0.0044 0.0057 0.0055
Schistosoma mansoni heat shock protein 0.0031 0.0034 0.0032
Echinococcus multilocularis caspase 2 0.0032 0.0035 0.0033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0007 0.0007
Trypanosoma cruzi DNA repair protein, putative 0.0034 0.0039 0.3801
Echinococcus multilocularis peroxidasin 0.0027 0.0026 0.0024
Schistosoma mansoni ap endonuclease 0.0023 0.0019 0.0017
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0044 0.0042
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0024 0.3738
Brugia malayi MH2 domain containing protein 0.0017 0.0008 0.0008
Echinococcus granulosus RUN 0.002 0.0014 0.0012
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0027 0.0027
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0014 0.0481
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0044 0.0379
Loa Loa (eye worm) Smad1 0.0017 0.0008 0.0008
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0062 0.6153
Schistosoma mansoni heat shock protein 0.0047 0.0062 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0044 0.0404
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0034 0.1144
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Brugia malayi hypothetical protein 0.002 0.0014 0.0014
Echinococcus granulosus sentrin specific protease 8 0.0068 0.0099 0.0097
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0026 0.0026
Echinococcus granulosus Niemann Pick C1 protein 0.0288 0.0491 0.0489
Chlamydia trachomatis replicative DNA helicase 0.0395 0.0683 1
Echinococcus multilocularis Smad4 0.0017 0.0008 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0044 0.0404
Brugia malayi hypothetical protein 0.0125 0.0202 0.0202
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0049 0.0458
Entamoeba histolytica hypothetical protein 0.0074 0.0109 0.1033
Brugia malayi CHE-14 protein 0.0086 0.0132 0.0132
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0641 0.0641
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0099 0.0936
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.004 0.6427
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.0039
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.011 0.0175 0.0175
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0238
Brugia malayi Cell death protein 3 precursor 0.0032 0.0035 0.0035
Brugia malayi hypothetical protein 0.0027 0.0026 0.0026
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0024 0.082
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0292 0.0499 0.0799
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0034 0.0032
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0008 0.0006
Leishmania major hypothetical protein, conserved 0.0037 0.0044 0.7025
Brugia malayi MH2 domain containing protein 0.0244 0.0413 0.0413
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0069 0.0069
Trichomonas vaginalis esterase, putative 0.0037 0.0044 0.0404
Echinococcus granulosus tar DNA binding protein 0.0065 0.0094 0.0092
Echinococcus multilocularis muscleblind protein 0.0306 0.0523 0.0521
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0034 0.0307
Schistosoma mansoni smad 0.0017 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Brugia malayi MH2 domain containing protein 0.0017 0.0008 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0044 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0044 0.4322
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Plasmodium falciparum heat shock protein 90, putative 0.0178 0.0295 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0056 0.1899
Schistosoma mansoni polycystin 1-related 0.002 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.006 0.0085 0.0085
Onchocerca volvulus Huntingtin homolog 0.0125 0.0202 1
Echinococcus granulosus heat shock protein 90 0.0047 0.0062 0.006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0542
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0044 0.0404
Echinococcus granulosus dnaJ subfamily B 0.0418 0.0723 0.0722
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0044 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0044 0.0404
Brugia malayi hypothetical protein 0.002 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0094 0.0092
Echinococcus multilocularis expressed conserved protein 0.0189 0.0315 0.0314
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0598 0.1043 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0044 0.0379
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0094 0.0094
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0008 0.0006
Leishmania major heat shock protein 83-1 0.0047 0.0062 1
Schistosoma mansoni hypothetical protein 0.0083 0.0127 0.0125
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0035
Echinococcus granulosus peroxidasin 0.0027 0.0026 0.0024
Echinococcus multilocularis lamin 0.0028 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.0044
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0062 0.6153
Echinococcus multilocularis heat shock protein 90 0.0047 0.0062 0.006
Echinococcus granulosus apoptotic protease activating factor 1 0.0032 0.0035 0.0033
Leishmania major importin beta-1 subunit, putative 0.0028 0.0029 0.447
Echinococcus multilocularis snurportin 1 0.0372 0.0641 0.0639
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0029 0.275
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0094 0.0092
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0029 0.0257
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.1236 0.1235
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0014 0.0481
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0024 0.082
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Onchocerca volvulus 0.002 0.0014 0.0704
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0029 0.0257
Plasmodium falciparum endoplasmin, putative 0.0034 0.0039 0.1318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0026
Treponema pallidum heat shock protein 90 0.0044 0.0057 0.037
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0062 0.0576
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0044 0.0044
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0013 0.1174

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.7016 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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