Detailed information for compound 1456372

Basic information

Technical information
  • TDR Targets ID: 1456372
  • Name: (5S)-1-[2-[3,5-bis(trifluoromethyl)phenyl]eth yl]-5-butan-2-yl-4,5-dihydroimidazol-2-amine
  • MW: 381.359 | Formula: C17H21F6N3
  • H donors: 1 H acceptors: 0 LogP: 4.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC([C@H]1CN=C(N1CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)N)C
  • InChi: 1S/C17H21F6N3/c1-3-10(2)14-9-25-15(24)26(14)5-4-11-6-12(16(18,19)20)8-13(7-11)17(21,22)23/h6-8,10,14H,3-5,9H2,1-2H3,(H2,24,25)/t10?,14-/m1/s1
  • InChiKey: JPJRQHSTSXMSNH-LNUXAPHWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5S)-1-[2-[3,5-bis(trifluoromethyl)phenyl]ethyl]-5-sec-butyl-4,5-dihydroimidazol-2-amine
  • [(5S)-1-[2-[3,5-bis(trifluoromethyl)phenyl]ethyl]-5-sec-butyl-4,5-dihydroimidazol-2-yl]amine
  • MLS000888843
  • SMR000462310

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0143 0.0134
Leishmania major cathepsin L-like protease 0.0066 0.0152 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0049 0.0043
Schistosoma mansoni hypothetical protein 0.0088 0.0216 0.0207
Loa Loa (eye worm) glutaminase 2 0.0291 0.0801 0.0801
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0025 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0142 0.014
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0025 0.1115
Echinococcus multilocularis cpg binding protein 0.0066 0.0152 0.0146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0012 0.0221
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0025 0.0023
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.04 0.7598
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0049 0.004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.0586 0.0585
Schistosoma mansoni hypothetical protein 0.0175 0.0467 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0012 0.0123
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0143 0.156
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0059 0.1188
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0859 1
Schistosoma mansoni microtubule-associated protein tau 0.0714 0.2019 0.2012
Loa Loa (eye worm) hypothetical protein 0.0066 0.0152 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0009 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0247 0.0241
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0083 0.0074
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0016 0.0015
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0065 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Loa Loa (eye worm) hypothetical protein 0.0088 0.0216 0.0215
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0025 0.0053
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0049 0.3114
Schistosoma mansoni tyrosine kinase 0.013 0.0335 0.0327
Echinococcus granulosus peregrin 0.0033 0.0056 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0012 0.0221
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0009 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1309
Echinococcus multilocularis 0.0017 0.0011 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0025 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0055 0.0046
Brugia malayi Protein kinase domain containing protein 0.0072 0.017 0.0163
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0012 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Brugia malayi Doublecortin family protein 0.002 0.0021 0.0015
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0136 0.0424
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0014 0.0002 0.0033
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0012 0.0003
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0088 0.0216 0.021
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.04 0.8016
Echinococcus granulosus geminin 0.0175 0.0467 0.0461
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0025 0.1553
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0012 0.0205
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0012 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0041
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0021 0.0232
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0006
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0185 0.0494 1
Echinococcus multilocularis geminin 0.0175 0.0467 0.0461
Trichomonas vaginalis rotamase, putative 0.0035 0.0062 0.0708
Brugia malayi hypothetical protein 0.0161 0.0426 0.042
Giardia lamblia GTOR 0.0022 0.0025 0.0044
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.0104 0.2096
Echinococcus multilocularis zinc finger protein 0.0024 0.0032 0.0026
Trypanosoma brucei unspecified product 0.0014 0.0003 0.0087
Schistosoma mansoni tyrosine kinase 0.0059 0.0133 0.0124
Schistosoma mansoni rab6-interacting 0.002 0.0021 0.0012
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0062 0.1259
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0003 0.0087
Loa Loa (eye worm) TK/EGFR protein kinase 0.0059 0.0133 0.0132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0019 0.0013
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0049 0.0132
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.1054 0.3 0.3003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.0859 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0021 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.3478 0.9985 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0012 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0143 0.156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Loa Loa (eye worm) hypothetical protein 0.0161 0.0426 0.0425
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0012 0.0006
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0132 0.0342 0.0337
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0049 0.0043
Schistosoma mansoni lipoxygenase 0.0122 0.0314 0.0305
Loa Loa (eye worm) TK/INSR protein kinase 0.013 0.0335 0.0334
Echinococcus multilocularis RUN 0.002 0.0021 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0859 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0143 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Echinococcus granulosus cathepsin l1 0.0017 0.0012 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0055 0.111
Schistosoma mansoni glutaminase 0.0291 0.0801 0.0793
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0072 0.0067
Leishmania major DNA polymerase eta, putative 0.0034 0.0059 0.3467
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0049 0.0549
Schistosoma mansoni hypothetical protein 0.0088 0.0216 0.0207
Treponema pallidum fructose-bisphosphate aldolase 0.0311 0.0859 1
Plasmodium falciparum phd finger protein, putative 0.003 0.0049 0.0971
Brugia malayi PHD-finger family protein 0.003 0.0049 0.0043
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0152 0.0479
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0012 0.0006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0302 0.6106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0188 0.0179
Giardia lamblia PHD finger protein 15 0.003 0.0049 0.033
Onchocerca volvulus 0.0246 0.0672 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0012 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0012 0.0006
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0062 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123
Schistosoma mansoni hypothetical protein 0.0175 0.0467 0.0458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0088 0.0216 0.0207
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0025 0.0154
Brugia malayi jmjC domain containing protein 0.0099 0.0247 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0062 0.3714
Echinococcus multilocularis expressed protein 0.0036 0.0065 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0021 0.0401
Schistosoma mansoni apoptosis regulator bax 0.0088 0.0216 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0059 0.0133 0.0127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0009 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0002 0.0002
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0021 0.0401
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0021 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0041
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0025 0.0019
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0205
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0152 0.0479
Brugia malayi Furin-like cysteine rich region family protein 0.0059 0.0133 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0859 1
Schistosoma mansoni DNA polymerase eta 0.0048 0.01 0.0091
Loa Loa (eye worm) hypothetical protein 0.0175 0.0465 0.0464
Schistosoma mansoni hypothetical protein 0.002 0.0021 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.001
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0062 0.0593
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0083 0.0077
Schistosoma mansoni cpg binding protein 0.006 0.0136 0.0127
Plasmodium vivax vivapain-2 0.0017 0.0012 0.0221
Schistosoma mansoni protein kinase 0.3483 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0025 0.0016
Echinococcus multilocularis peregrin 0.0033 0.0056 0.005
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0185 0.0494 0.6063
Mycobacterium ulcerans glutaminase 0.0291 0.0801 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0021 0.0858
Loa Loa (eye worm) doublecortin family protein 0.002 0.0021 0.0019
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.0133 0.0127
Plasmodium vivax SET domain protein, putative 0.0032 0.0055 0.109
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0055 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0143 0.936
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.002
Trypanosoma brucei unspecified product 0.0014 0.0003 0.0087
Onchocerca volvulus 0.006 0.0136 0.1877
Schistosoma mansoni rab6-interacting 0.002 0.0021 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0143 0.2894
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0021 0.0015
Brugia malayi Bromodomain containing protein 0.0041 0.008 0.0073
Schistosoma mansoni hypothetical protein 0.0022 0.0025 0.0016
Echinococcus granulosus zinc finger protein 0.0024 0.0032 0.0026
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0025 0.1115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123
Schistosoma mansoni rotamase 0.0036 0.0065 0.0056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0037 0.0028
Brugia malayi Pre-SET motif family protein 0.0217 0.0586 0.058
Schistosoma mansoni loxhd1 0.002 0.0021 0.0012
Schistosoma mansoni hypothetical protein 0.003 0.0049 0.004
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0025 0.1553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0083 0.0074
Echinococcus granulosus microtubule associated protein 2 0.0714 0.2019 0.2014
Brugia malayi Protein kinase domain containing protein 0.013 0.0335 0.0329
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0006
Brugia malayi Bromodomain containing protein 0.0033 0.0056 0.005
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.0133 0.0127
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0014 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0065 0.0736
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0334 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0012 0.0123
Plasmodium vivax hypothetical protein, conserved 0.003 0.0049 0.0971
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0062 0.4024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0859 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.0104 0.2096
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.0859 1
Echinococcus multilocularis dna polymerase eta 0.0048 0.01 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123
Schistosoma mansoni hypothetical protein 0.0088 0.0216 0.0207
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0012 0.001
Onchocerca volvulus 0.0032 0.0055 0.065
Echinococcus multilocularis ephrin type A receptor 4 A 0.0068 0.0157 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0041 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Trichomonas vaginalis set domain proteins, putative 0.0246 0.0672 0.7813
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0021 0.0015
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0025 0.0019
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0021 0.0012
Entamoeba histolytica hypothetical protein 0.0049 0.0104 0.1081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0049 0.0042
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.0078
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0059 0.0166
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.01 0.0303
Echinococcus granulosus RUN 0.002 0.0021 0.0015
Onchocerca volvulus 0.0175 0.0465 0.6868
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Leishmania major cathepsin L-like protease 0.0066 0.0152 1
Schistosoma mansoni polycystin 1-related 0.002 0.0021 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Onchocerca volvulus 0.002 0.0021 0.0134
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0155 0.0149
Schistosoma mansoni tyrosine kinase 0.0058 0.0128 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0003 0.0087
Echinococcus granulosus L aminoadipate semialdehyde 0.0175 0.0465 0.046
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0012 0.0006
Schistosoma mansoni cpg binding protein 0.0066 0.0152 0.0143
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0088 0.0216 0.0211
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0025 0.0053
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0025 0.0023
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0012 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trypanosoma brucei ISWI complex protein 0.0016 0.0009 0.0493
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0049 0.0991
Brugia malayi Pre-SET motif family protein 0.0032 0.0055 0.0049
Echinococcus multilocularis L aminoadipate semialdehyde 0.0175 0.0465 0.046
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0083 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0025 0.1553
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0025 0.1553
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0104 0.677
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.0104 0.1739
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0859 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1309
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.0133 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0052 0.0111 0.011
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0014 0.0009
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0025 0.1115
Loa Loa (eye worm) hypothetical protein 0.0075 0.0179 0.0178
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0019 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Loa Loa (eye worm) histone methyltransferase 0.002 0.0019 0.0018
Onchocerca volvulus Alhambra homolog 0.003 0.0049 0.0561
Plasmodium falciparum enoyl-acyl carrier reductase 0.0185 0.0494 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0311 0.0859 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0025 0.1115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0107 0.0098
Loa Loa (eye worm) cysteine protease 0.0017 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.007 0.0164 0.0163
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0021 0.0232
Entamoeba histolytica hypothetical protein 0.003 0.0049 0.0431
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0025 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0106
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0175 0.0465 0.0457
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0025 0.1553
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0005
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0025 0.0053
Brugia malayi ephrin receptor 1 precursor 0.0033 0.0057 0.005
Loa Loa (eye worm) TK/EPH protein kinase 0.0086 0.0209 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0021 0.011
Schistosoma mansoni protein kinase 0.3483 1 1
Brugia malayi PHD-finger family protein 0.003 0.0048 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Echinococcus multilocularis insulin receptor 0.013 0.0335 0.033
Leishmania major DNA polymerase kappa, putative 0.0021 0.0021 0.0858
Loa Loa (eye worm) ctsf protein 0.0017 0.0012 0.001
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0014 0.0009
Schistosoma mansoni ephrin receptor 0.0068 0.0157 0.0148
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0025 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0041
Toxoplasma gondii FATC domain-containing protein 0.003 0.0049 0.0982
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.04 0.486
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1054 0.3 1
Trichomonas vaginalis glutaminase, putative 0.0291 0.0801 0.9323
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.01 0.0093
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0185 0.0494 1
Loa Loa (eye worm) glutaminase 0.0291 0.0801 0.0801
Plasmodium vivax vivapain-2 0.0017 0.0012 0.0221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123
Schistosoma mansoni tyrosine kinase 0.0059 0.0133 0.0124
Echinococcus multilocularis cysteine protease 0.0017 0.0012 0.0006
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0025 0.1123
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0041 0.0032
Echinococcus granulosus dna polymerase eta 0.0048 0.01 0.0094
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0088 0.0216 0.0211
Schistosoma mansoni hypothetical protein 0.0859 0.2437 0.243
Trichomonas vaginalis hypothetical protein 0.0185 0.0494 0.5744
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0021 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0101
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0049 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0036 0.0091
Echinococcus granulosus insulin receptor 0.013 0.0335 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0049 0.004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0155 0.0149
Leishmania major cathepsin L-like protease 0.0066 0.0152 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0185 0.0494 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0019
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0025 0.0019
Echinococcus granulosus dna polymerase kappa 0.0021 0.0021 0.0015
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0185 0.0494 1
Loa Loa (eye worm) fibroinase 0.0017 0.0012 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0025 0.0053
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0041 0.0035
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0175 0.0465 0.0459
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0132 0.0342 0.0337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Schistosoma mansoni cpg binding protein 0.0066 0.0152 0.0143
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0025 0.0024
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0025 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0003 0.0087
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0152 0.0479
Loa Loa (eye worm) hypothetical protein 0.0048 0.01 0.0098
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0062 0.0178
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0015
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0314 0.0308
Brugia malayi jmjC domain containing protein 0.0042 0.0083 0.0077
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.3483 1 1
Leishmania major DNA polymerase eta, putative 0.0048 0.01 0.6321
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0055 0.0046
Brugia malayi hypothetical protein 0.002 0.0021 0.0015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0021 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0143 0.156
Onchocerca volvulus 0.002 0.0021 0.0134
Schistosoma mansoni tyrosine kinase 0.013 0.0335 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0185 0.0494 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0104 0.2078
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0314 0.0308
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0104 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Brugia malayi glutaminase DH11.1 0.0291 0.0801 0.0796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0049 0.0047
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.0133 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0859 1
Schistosoma mansoni tyrosine kinase 0.0058 0.0128 0.0119
Echinococcus multilocularis microtubule associated protein 2 0.0714 0.2019 0.2014
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0025 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0107 0.0101
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0021 0.0015
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0205
Brugia malayi hypothetical protein 0.002 0.0021 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0152 0.0479
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0006
Trypanosoma brucei unspecified product 0.0021 0.0021 0.1309
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0185 0.0494 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0025 0.1115
Brugia malayi Bromodomain containing protein 0.0083 0.0202 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Echinococcus granulosus expressed protein 0.0036 0.0065 0.0059
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0112 0.0343
Echinococcus granulosus dnaJ subfamily B 0.0859 0.2437 0.2433
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0067 0.0061
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2784 0.278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0012 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0143 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0143 0.2573
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0048 0.0042
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1054 0.3 1
Loa Loa (eye worm) apoptosis regulator protein 0.0088 0.0216 0.0215
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.3483 1 1
Echinococcus multilocularis cysteine protease 0.0017 0.0012 0.0006
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0014 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0859 0.2437 0.2433
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.0104 0.6602
Loa Loa (eye worm) hypothetical protein 0.1049 0.2985 0.2988
Schistosoma mansoni lipoxygenase 0.0085 0.0208 0.0199
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0088 0.0216 0.0211
Leishmania major cathepsin L-like protease 0.0017 0.0012 0.0205
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.0104 0.1054
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0088 0.0216 0.0211
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0107 0.0101
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0083 0.0077
Schistosoma mansoni zinc finger protein 0.0024 0.0032 0.0023
Echinococcus granulosus cpg binding protein 0.0066 0.0152 0.0146
Schistosoma mansoni tyrosine kinase 0.0059 0.0133 0.0124
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0025 0.0053
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0247 0.0241
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.01 0.6503
Loa Loa (eye worm) hypothetical protein 0.0043 0.0087 0.0086
Echinococcus granulosus serine protein kinase ATM 0.003 0.0049 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0859 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0107 0.0098
Brugia malayi Cathepsin L-like precursor 0.0017 0.0012 0.0006
Onchocerca volvulus 0.0161 0.0426 0.6275
Trichomonas vaginalis rotamase, putative 0.0036 0.0065 0.0736
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0053 0.0046
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0049 0.0991
Schistosoma mansoni tyrosine kinase 0.0058 0.0128 0.0119
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1309
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0012 0.0221
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0136 0.0134
Onchocerca volvulus 0.0066 0.0152 0.2119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0152 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0143 0.0137
Brugia malayi CXXC zinc finger family protein 0.006 0.0136 0.013
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0065 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.0859 1
Schistosoma mansoni bromodomain containing protein 0.0071 0.0166 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1309
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0072 0.0067
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0083 0.0077
Toxoplasma gondii cathepsin CPL 0.0017 0.0012 0.0243
Echinococcus granulosus ephrin type A receptor 4 A 0.0068 0.0157 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0025 0.0275
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0025 0.0054
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0047
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.0104 0.1054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0012 0.0123

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6611 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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