TDR Targets

Basic information

Technical information

TDR Targets ID: 1458796
Name: ethyl 4-[4-[(3-chloro-4-methylphenyl)carbamoy l]piperidin-1-yl]sulfonyl-2,5-dimethyl-1H-pyr role-3-carboxylate
MW: 481.993 | Formula: C22H28ClN3O5S
H donors: 2 H acceptors: 4 LogP: 3.2 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1c(C)[nH]c(c1S(=O)(=O)N1CCC(CC1)C(=O)Nc1ccc(c(c1)Cl)C)C
InChi: 1S/C22H28ClN3O5S/c1-5-31-22(28)19-14(3)24-15(4)20(19)32(29,30)26-10-8-16(9-11-26)21(27)25-17-7-6-13(2)18(23)12-17/h6-7,12,16,24H,5,8-11H2,1-4H3,(H,25,27)
InChiKey: RARGNQVQFHPHGK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 4-[[4-[(3-chloro-4-methyl-phenyl)carbamoyl]-1-piperidyl]sulfonyl]-2,5-dimethyl-1H-pyrrole-3-carboxylate
4-[[4-[[(3-chloro-4-methylphenyl)amino]-oxomethyl]-1-piperidinyl]sulfonyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
4-[[4-[(3-chloro-4-methyl-phenyl)carbamoyl]-1-piperidyl]sulfonyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
ethyl 4-[4-[(3-chloro-4-methyl-phenyl)carbamoyl]piperidin-1-yl]sulfonyl-2,5-dimethyl-1H-pyrrole-3-carboxylate
G070-0088
NCGC00128470-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Photinus pyralis	Luciferin 4-monooxygenase	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Entamoeba histolytica	acyl-coA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania donovani	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Entamoeba histolytica	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Get druggable targets OG5_126609	All targets in OG5_126609
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium berghei	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania braziliensis	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus		Get druggable targets OG5_126609	All targets in OG5_126609
Entamoeba histolytica	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium knowlesi	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Mycobacterium ulcerans	fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania donovani	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium yoelii	peroxisomal-coenzyme a synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium falciparum	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium vivax	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	494 aa	23.9 %
Trypanosoma brucei gambiense	fatty acyl CoA synthetase 4, putative	Luciferin 4-monooxygenase	550 aa	497 aa	23.7 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	476 aa	20.8 %
Trypanosoma congolense	fatty acyl CoA synthetase 2, putative	Luciferin 4-monooxygenase	550 aa	500 aa	22.4 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase	Luciferin 4-monooxygenase	550 aa	541 aa	22.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	522 aa	19.9 %
Leishmania donovani	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	500 aa	23.4 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	593 aa	22.1 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	586 aa	24.4 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	550 aa	20.9 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 5	Luciferin 4-monooxygenase	550 aa	458 aa	25.5 %
Onchocerca volvulus		Luciferin 4-monooxygenase	550 aa	502 aa	24.9 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	539 aa	22.1 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	542 aa	23.8 %
Trichomonas vaginalis	long-chain-fatty-acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	490 aa	23.3 %
Mycobacterium leprae	FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	533 aa	22.7 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.6 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	524 aa	24.0 %
Trypanosoma brucei gambiense	fatty acyl CoA synthetase 3	Luciferin 4-monooxygenase	550 aa	491 aa	23.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	18.3 %
Leishmania mexicana	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	483 aa	23.8 %
Trypanosoma cruzi	fatty acyl CoA synthetase 2, putative	Luciferin 4-monooxygenase	550 aa	495 aa	22.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	478 aa	21.1 %
Leishmania infantum	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	500 aa	23.4 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	480 aa	21.5 %
Echinococcus multilocularis	long chain fatty acid transport protein 4	Luciferin 4-monooxygenase	550 aa	476 aa	22.3 %
Toxoplasma gondii	propionate-CoA ligase	Luciferin 4-monooxygenase	550 aa	550 aa	21.1 %
Trichomonas vaginalis	long-chain-fatty-acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	466 aa	21.7 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	538 aa	21.8 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	497 aa	19.3 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	463 aa	23.5 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	545 aa	24.9 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase, FadD11	Luciferin 4-monooxygenase	550 aa	492 aa	24.6 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase FadD15	Luciferin 4-monooxygenase	550 aa	484 aa	26.0 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	527 aa	25.0 %
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Luciferin 4-monooxygenase	550 aa	518 aa	19.1 %
Dictyostelium discoideum	acetyl-CoA ligase	Luciferin 4-monooxygenase	550 aa	549 aa	22.2 %
Leishmania braziliensis	long-chain-fatty-acid-CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	504 aa	25.6 %
Trichomonas vaginalis	antibiotic synthetase, putative	Luciferin 4-monooxygenase	550 aa	577 aa	22.2 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	494 aa	24.3 %
Babesia bovis	long-chain acyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	445 aa	21.8 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	22.1 %
Brugia malayi	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	544 aa	21.5 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	531 aa	19.0 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	535 aa	22.6 %
Onchocerca volvulus	Lysine-specific histone demethylase 1A homolog	Luciferin 4-monooxygenase	550 aa	550 aa	22.5 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	18.3 %
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	Luciferin 4-monooxygenase	550 aa	509 aa	22.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	542 aa	22.1 %
Leishmania mexicana	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	559 aa	20.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	499 aa	19.2 %
Leishmania major	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	482 aa	23.2 %
Entamoeba histolytica	acyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	446 aa	22.0 %
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	Luciferin 4-monooxygenase	550 aa	476 aa	22.5 %
Cryptosporidium parvum	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	460 aa	25.7 %
Mycobacterium ulcerans	putative fatty-acid--CoA ligase	Luciferin 4-monooxygenase	550 aa	576 aa	20.8 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	537 aa	20.9 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	452 aa	26.1 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	442 aa	23.5 %
Babesia bovis	fatty acyl-CoA synthetase family protein	Luciferin 4-monooxygenase	550 aa	461 aa	23.4 %
Mycobacterium tuberculosis	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)	Luciferin 4-monooxygenase	550 aa	592 aa	20.4 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	539 aa	19.1 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferin 4-monooxygenase	550 aa	517 aa	24.8 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	554 aa	24.4 %
Leishmania braziliensis	long chain fatty Acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	496 aa	22.8 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	582 aa	22.3 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	526 aa	21.9 %
Echinococcus granulosus	long chain fatty acid transport protein 4	Luciferin 4-monooxygenase	550 aa	476 aa	22.3 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	535 aa	21.7 %
Theileria parva	long-chain fatty acid CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	507 aa	23.5 %
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	461 aa	22.3 %
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	Luciferin 4-monooxygenase	550 aa	535 aa	23.2 %
Mycobacterium leprae	PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	565 aa	22.8 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	484 aa	20.5 %
Neospora caninum	acetyl-coenzyme a synthetase, putative	Luciferin 4-monooxygenase	550 aa	549 aa	20.9 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	560 aa	21.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	558 aa	20.4 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	541 aa	21.6 %
Cryptosporidium hominis	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	460 aa	26.1 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	443 aa	26.4 %
Mycobacterium leprae	Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferin 4-monooxygenase	550 aa	484 aa	23.3 %
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	496 aa	24.2 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	539 aa	19.1 %
Schistosoma japonicum	ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative	Luciferin 4-monooxygenase	550 aa	466 aa	27.3 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	543 aa	24.5 %
Schistosoma mansoni	FAA1 Long-chain-fatty-acid--CoA ligase 1	Luciferin 4-monooxygenase	550 aa	494 aa	26.3 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	476 aa	23.5 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	493 aa	20.7 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	543 aa	24.5 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity.	Luciferin 4-monooxygenase	550 aa	487 aa	22.4 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 1	Luciferin 4-monooxygenase	550 aa	459 aa	27.0 %
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	Luciferin 4-monooxygenase	550 aa	493 aa	22.1 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	530 aa	23.8 %
Leishmania braziliensis	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	596 aa	21.1 %
Toxoplasma gondii	type I fatty acid synthase, putative	Luciferin 4-monooxygenase	550 aa	514 aa	19.8 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	529 aa	22.3 %
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	Luciferin 4-monooxygenase	550 aa	509 aa	21.8 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	480 aa	22.5 %
Trypanosoma cruzi	fatty acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	482 aa	24.7 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	601 aa	22.5 %
Trichomonas vaginalis	antibiotic synthetase, putative	Luciferin 4-monooxygenase	550 aa	581 aa	21.2 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	538 aa	21.8 %
Loa Loa (eye worm)	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	489 aa	23.3 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	475 aa	21.1 %
Candida albicans	similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase	Luciferin 4-monooxygenase	550 aa	478 aa	23.4 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	526 aa	22.4 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	Luciferin 4-monooxygenase	550 aa	558 aa	20.1 %
Dictyostelium discoideum	fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	501 aa	24.4 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase FadD15	Luciferin 4-monooxygenase	550 aa	482 aa	24.3 %
Schistosoma japonicum	ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative	Luciferin 4-monooxygenase	550 aa	541 aa	22.4 %
Cryptosporidium hominis	acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme)	Luciferin 4-monooxygenase	550 aa	549 aa	22.6 %
Cryptosporidium parvum	putative long chain fatty acyl CoA synthetase having a signal peptide	Luciferin 4-monooxygenase	550 aa	472 aa	24.8 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	617 aa	22.2 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 5	Luciferin 4-monooxygenase	550 aa	458 aa	25.8 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	Luciferin 4-monooxygenase	550 aa	502 aa	22.5 %
Onchocerca volvulus	Matrilysin homolog	Luciferin 4-monooxygenase	550 aa	466 aa	24.2 %
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD11	Luciferin 4-monooxygenase	550 aa	498 aa	23.5 %
Brugia malayi	AMP-binding enzyme family protein	Luciferin 4-monooxygenase	550 aa	497 aa	24.7 %
Dictyostelium discoideum	fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	462 aa	23.8 %
Cryptosporidium parvum	acetyl-coenzyme A synthetase	Luciferin 4-monooxygenase	550 aa	545 aa	22.8 %
Onchocerca volvulus		Luciferin 4-monooxygenase	550 aa	487 aa	23.8 %
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	496 aa	24.2 %
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	Luciferin 4-monooxygenase	550 aa	536 aa	24.4 %
Trypanosoma cruzi	fatty acyl CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	480 aa	25.2 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferin 4-monooxygenase	550 aa	554 aa	22.9 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferin 4-monooxygenase	550 aa	492 aa	23.6 %
Trypanosoma brucei	fatty acyl CoA synthetase 3	Luciferin 4-monooxygenase	550 aa	491 aa	23.6 %
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD9	Luciferin 4-monooxygenase	550 aa	463 aa	21.8 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	576 aa	19.8 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferin 4-monooxygenase	550 aa	504 aa	22.6 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	507 aa	20.9 %
Dictyostelium discoideum	hypothetical protein	Luciferin 4-monooxygenase	550 aa	522 aa	19.9 %
Leishmania braziliensis	acetyl-CoA synthetase, putative	Luciferin 4-monooxygenase	550 aa	603 aa	22.6 %
Trichomonas vaginalis	AMP dependent ligase, putative	Luciferin 4-monooxygenase	550 aa	445 aa	26.1 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferin 4-monooxygenase	550 aa	505 aa	28.1 %
Schistosoma japonicum	ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative	Luciferin 4-monooxygenase	550 aa	501 aa	24.6 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferin 4-monooxygenase	550 aa	539 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0411	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0017
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0738	0.0732
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0275	0.0275
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0411	0.0551
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0182	0.0176
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0284	0.302	0.2993
Schistosoma mansoni	hypothetical protein	0.0191	0.1993	0.1993
Onchocerca volvulus		0.0032	0.0253	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0017
Echinococcus granulosus	smad	0.001	0.0006	0.0006
Loa Loa (eye worm)	malate dehydrogenase	0.0284	0.302	0.3016
Schistosoma mansoni	cathepsin F (C01 family)	0.0039	0.0322	0.0322
Onchocerca volvulus		0.006	0.0554	0.1887
Loa Loa (eye worm)	malate dehydrogenase	0.0292	0.3106	0.3102
Onchocerca volvulus		0.0026	0.0182	0.0564
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0913	0.9921	0.9921
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0184	0.0178
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0322	0.0316
Chlamydia trachomatis	malate dehydrogenase	0.0292	0.3106	1
Entamoeba histolytica	malate dehydrogenase, putative	0.0612	0.6616	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Brugia malayi	Pre-SET motif family protein	0.0034	0.0275	0.0269
Leishmania major	malate dehydrogenase, putative	0.0264	0.279	0.2755
Echinococcus multilocularis	cathepsin L	0.002	0.0116	0.0116
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0411	0.1314
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0182	0.0182
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Schistosoma mansoni	carbonic anhydrase-related	0.0499	0.5369	0.5369
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0514	0.0509
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0049	0.0147
Schistosoma mansoni	L-lactate dehydrogenase	0.0264	0.279	0.279
Onchocerca volvulus		0.0039	0.0322	0.1063
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0275	0.0275
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0049	0.0043
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0072	0.0692	0.0656
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0022	0.0016
Schistosoma mansoni	ferritin light chain	0.001	0.0003	0.0003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0499	0.5369	0.5366
Echinococcus granulosus	tumor protein p63	0.0408	0.4376	0.4376
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0253	0.0247
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0023	0.0023
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0738	0.0738
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0023	0.0017
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0023	0.0023
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0584	0.0816
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0116	0.0078
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0093	0.0087
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Schistosoma mansoni	smad	0.001	0.0006	0.0006
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0014	0.0049	0.0147
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0049	0.0043
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0022	0.0022
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0292	0.3106	1
Onchocerca volvulus		0.0014	0.0049	0.0091
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0921	1	1
Toxoplasma gondii	cathepsin CPL	0.0039	0.0322	0.0416
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0023	0.0017
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0023	0.0023
Trypanosoma cruzi	cruzipain precursor, putative	0.0085	0.0832	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0612	0.6616	0.6614
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0023	0.0023
Echinococcus granulosus	cathepsin L cysteine protease	0.002	0.0116	0.0116
Schistosoma mansoni	lamin	0.0026	0.0189	0.0189
Echinococcus multilocularis	dnaJ subfamily B	0.0461	0.4954	0.4954
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0023	0.0017
Echinococcus granulosus	malate dehydrogenase	0.0284	0.302	0.302
Echinococcus multilocularis	cpg binding protein	0.0034	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0043
Entamoeba histolytica	malate dehydrogenase, putative	0.0292	0.3106	0.4655
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0281	0.0896
Trypanosoma cruzi	malate dehydrogenase, putative	0.0284	0.302	0.2993
Schistosoma mansoni	L-lactate dehydrogenase	0.0612	0.6616	0.6616
Schistosoma mansoni	ferritin	0.001	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0514	0.0509
Brugia malayi	lactate dehydrogenase.	0.0612	0.6616	0.6614
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0176
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0023	0.0023
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0014	0.0049	0.0147
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.026	0.0829
Schistosoma mansoni	ferritin light chain	0.001	0.0003	0.0003
Echinococcus granulosus	geminin	0.0191	0.1993	0.1993
Echinococcus multilocularis	ferritin	0.001	0.0003	0.0003
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0921	1	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.0921	1	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.0322	0.0416
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0014	0.0049	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0038	0.0032
Toxoplasma gondii	malate dehydrogenase MDH	0.0612	0.6616	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0049	0.0147
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0023	0.0023
Onchocerca volvulus		0.0014	0.0049	0.0091
Echinococcus granulosus	dnaJ subfamily B	0.0461	0.4954	0.4954
Trichomonas vaginalis	set domain proteins, putative	0.0268	0.2834	0.9123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0182	0.0576
Echinococcus granulosus	lamin	0.0026	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0043
Trypanosoma cruzi	cysteine peptidase, putative	0.0039	0.0322	0.0285
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0006	0.0006
Schistosoma mansoni	malate dehydrogenase	0.0612	0.6616	0.6616
Echinococcus granulosus	carbonic anhydrase	0.0499	0.5369	0.5369
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0116	0.011
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0054	0.0048
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0006	0.0006
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0014	0.0049	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0027
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0411	0.1314
Echinococcus multilocularis	lamin	0.0026	0.0189	0.0189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0093	0.0093
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0049	0.001
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0292	0.3106	0.3106
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0039	0.0322	0.0322
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0738	0.0732
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0023	0.0017
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0023	0.0023
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0039	0.0322	0.0322
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0023	0.0017
Plasmodium vivax	malate dehydrogenase, putative	0.0612	0.6616	1
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0292	0.3106	1
Toxoplasma gondii	lactate dehydrogenase LDH2	0.0612	0.6616	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0281	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0281	0.0275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Brugia malayi	ecdysteroid receptor	0.0011	0.0023	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0093	0.0087
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0023	0.0023
Leishmania major	cathepsin L-like protease	0.0039	0.0322	0.0274
Brugia malayi	Cathepsin L-like precursor	0.0013	0.0038	0.0032
Leishmania major	malate dehydrogenase	0.0284	0.302	0.2986
Echinococcus multilocularis	L lactate dehydrogenase B chain	0.0612	0.6616	0.6616
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Echinococcus granulosus	carbonic anhydrase	0.0499	0.5369	0.5369
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0049	0.0147
Echinococcus granulosus	lactate dehydrogenase a	0.0612	0.6616	0.6616
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0023	0.0023
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0023	0.0017
Schistosoma mansoni	malate dehydrogenase	0.0284	0.302	0.302
Plasmodium vivax	lactate/malate dehydrogenase, putative	0.0264	0.279	0.4183
Echinococcus granulosus	cathepsin l1	0.0026	0.0182	0.0182
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.002	0.0116	0.0068
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0189	0.0189
Plasmodium vivax	SET domain protein, putative	0.0034	0.0275	0.036
Leishmania major	cathepsin L-like protease	0.0039	0.0322	0.0274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Trypanosoma cruzi	cysteine proteinase, putative	0.002	0.0116	0.0078
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0499	0.5369	0.5366
Leishmania major	carbonic anhydrase-like protein	0.0921	1	1
Schistosoma mansoni	malate dehydrogenase	0.0292	0.3106	0.3106
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0049	0.0147
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0018	0.0093	0.0093
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0411	0.1314
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0189	0.0183
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Echinococcus multilocularis	lactate dehydrogenase protein	0.0612	0.6616	0.6616
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0014	0.0049	0.0147
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.002	0.0014
Schistosoma mansoni	cpg binding protein	0.0034	0.0273	0.0273
Brugia malayi	Pre-SET motif family protein	0.0235	0.2478	0.2474
Leishmania major	cytosolic malate dehydrogenase	0.0292	0.3106	0.3072
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0292	0.3106	0.3106
Echinococcus multilocularis	malate dehydrogenase	0.0284	0.302	0.302
Toxoplasma gondii	lactate dehydrogenase LDH1	0.0612	0.6616	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0049	0.0147
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0181	0.0572
Echinococcus multilocularis	carbonic anhydrase	0.0499	0.5369	0.5369
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0017
Onchocerca volvulus		0.0039	0.0322	0.1063
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0012	0.0028	0.008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0033	0.0027
Trypanosoma cruzi	cysteine proteinase, putative	0.002	0.0116	0.0078
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Echinococcus multilocularis	L lactate dehydrogenase	0.0349	0.3724	0.3724
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.002	0.0116	0.0116
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0017
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0023	0.0017
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0022	0.0022
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0017
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.0322	0.0416
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0023	0.0017
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0281	0.0275
Onchocerca volvulus		0.0039	0.0322	0.1063
Echinococcus granulosus	ferritin	0.001	0.0003	0.0003
Schistosoma mansoni	ferritin	0.001	0.0003	0.0003
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0319	0.0314
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0039	0.0322	0.0416
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0116	0.0103
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0181	0.0201
Echinococcus granulosus	intermediate filament protein	0.0026	0.0189	0.0189
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0049	0.0147
Trichomonas vaginalis	malate dehydrogenase, putative	0.0157	0.1623	0.5221
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0006	0.0006
Onchocerca volvulus		0.0039	0.0322	0.1063
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0039	0.0322	0.0416
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Schistosoma mansoni	coup transcription factor	0.0011	0.0023	0.0023
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0411	0.0405
Echinococcus granulosus	carbonic anhydrase II	0.0921	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0039	0.0322	0.0322
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0322	0.0316
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0023	0.0017
Wolbachia endosymbiont of Brugia malayi	malate dehydrogenase	0.0612	0.6616	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0254	0.0254
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0023	0.0023
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Schistosoma mansoni	ferritin	0.001	0.0003	0.0003
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0921	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0038	0.0032
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0411	0.1314
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0499	0.5369	0.5366
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0116	0.0365
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0023	0.0017
Brugia malayi	Probable malate dehydrogenase, mitochondrial precursor	0.0284	0.302	0.3016
Schistosoma mansoni	hypothetical protein	0.0038	0.0319	0.0319
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0039	0.0322	0.0316
Schistosoma mansoni	Smad4	0.001	0.0006	0.0006
Brugia malayi	cathepsin F-like cysteine proteinase	0.0013	0.0038	0.0032
Echinococcus multilocularis	lactate dehydrogenase a	0.0612	0.6616	0.6616
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0253	0.0247
Loa Loa (eye worm)	oxidoreductase	0.0014	0.0049	0.0043
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0292	0.3106	0.308
Leishmania major	malate dehydrogenase, putative	0.0612	0.6616	0.66
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0921	1	1
Brugia malayi	Malate dehydrogenase, cytoplasmic	0.0292	0.3106	0.3102
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Schistosoma mansoni	ferritin	0.001	0.0003	0.0003
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0554	0.0554
Plasmodium falciparum	lactate dehydrogenase, putative	0.0264	0.279	0.4174
Echinococcus granulosus	expressed protein	0.001	0.0003	0.0003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Echinococcus multilocularis	cathepsin L cysteine protease	0.0039	0.0322	0.0322
Schistosoma mansoni	cpg binding protein	0.0034	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0499	0.5369	0.5366
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0281	0.0354
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0411	0.0551
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0023	0.0023
Echinococcus multilocularis	malate dehydrogenase	0.0284	0.302	0.302
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0499	0.5369	0.5366
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0189	0.0183
Brugia malayi	TAR-binding protein	0.0076	0.0738	0.0732
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0039	0.0322	0.0316
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0153	0.0153
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0049	0.0147
Echinococcus granulosus	malate dehydrogenase	0.0284	0.302	0.302
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0411	0.1314
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0017
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0499	0.5369	0.5366
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0275	0.0275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Echinococcus granulosus	L lactate dehydrogenase	0.0349	0.3724	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0322	0.0316
Onchocerca volvulus	Cathepsin L homolog	0.0039	0.0322	0.1063
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0023	0.0023
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.002	0.0116	0.0068
Treponema pallidum	bacterioferrin (TpF1)	0.001	0.0003	0.5
Echinococcus granulosus	cpg binding protein	0.0034	0.0273	0.0273
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0322	0.0316
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0049	0.0147
Schistosoma mansoni	lamin	0.0026	0.0189	0.0189
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0411	0.1314
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0049	0.0147
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0738	0.0738
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0411	0.0551
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0014	0.0049	0.001
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0049	0.0147
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0182	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0049	0.0147
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0049	0.0147
Plasmodium vivax	vivapain-3	0.002	0.0116	0.0119
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0038	0.0032
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0039	0.0322	0.0416
Schistosoma mansoni	carbonic anhydrase-related	0.0499	0.5369	0.5369
Echinococcus granulosus	lactate dehydrogenase a	0.0612	0.6616	0.6616
Plasmodium vivax	unspecified product	0.002	0.0116	0.0119
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0235	0.2478	0.2474
Echinococcus multilocularis	geminin	0.0191	0.1993	0.1993
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0006	0.0006
Schistosoma mansoni	carbonic anhydrase	0.0499	0.5369	0.5369
Trypanosoma brucei	mitochondrial malate dehydrogenase	0.0284	0.302	0.2986
Trichomonas vaginalis	malate dehydrogenase, putative	0.0264	0.279	0.8982
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0039	0.0322	0.1027
Plasmodium vivax	vivapain-1	0.002	0.0116	0.0119
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.002	0.0116	0.0116
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Schistosoma mansoni	cathepsin s	0.0013	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0275	0.0269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0275	0.0275
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0275	0.0275
Loa Loa (eye worm)	fibroinase	0.0039	0.0322	0.0316
Echinococcus multilocularis	Smad4	0.001	0.0006	0.0006
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0014	0.0049	0.0147
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0181	0.0201
Schistosoma mansoni	carbonic anhydrase-related	0.0499	0.5369	0.5369
Plasmodium falciparum	cysteine proteinase falcipain 1	0.002	0.0116	0.0103
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0181	0.0201
Echinococcus granulosus	cysteine protease	0.002	0.0116	0.0116
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0176
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0049	0.0147
Leishmania major	glycosomal malate dehydrogenase	0.0284	0.302	0.2986
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0411	0.0405
Mycobacterium leprae	PROBABLE MALATE DEHYDROGENASE MDH	0.0292	0.3106	1
Schistosoma mansoni	hypothetical protein	0.0191	0.1993	0.1993
Schistosoma mansoni	hypothetical protein	0.0018	0.0093	0.0093
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0181	0.0143
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0014	0.0049	0.0049
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0281	0.0369
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0738	0.0738
Schistosoma mansoni	acetyl-CoA synthetase	0.0014	0.0049	0.0049
Brugia malayi	steroid hormone receptor	0.0011	0.0023	0.0017
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.0665	0.0665
Plasmodium falciparum	L-lactate dehydrogenase	0.0612	0.6616	1
Plasmodium falciparum	malate dehydrogenase	0.0612	0.6616	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0049	0.0147
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0054	0.0048
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0738	0.0732
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0738	0.0732
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0411	0.0405
Schistosoma mansoni	smad1 5 8 and	0.001	0.0006	0.0006
Onchocerca volvulus		0.0026	0.0189	0.0589
Schistosoma mansoni	smad1 5 8 and	0.001	0.0006	0.0006
Trypanosoma brucei	malate dehydrogenase-related	0.0264	0.279	0.2755
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0322	0.0316
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0093	0.0093
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0181	0.0175
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0411	0.1314
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0006	0.0006
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0181	0.0132
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0049	0.0043
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0039	0.0322	0.0322
Echinococcus multilocularis	cathepsin L cysteine protease	0.0039	0.0322	0.0322
Echinococcus multilocularis	expressed protein	0.001	0.0003	0.0003
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0275	0.0275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Echinococcus multilocularis	lactate dehydrogenase a	0.0612	0.6616	0.6616
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0023	0.0023
Echinococcus granulosus	Smad4	0.001	0.0006	0.0006
Trypanosoma cruzi	mitochondrial malate dehydrogenase, putative	0.0284	0.302	0.2993
Onchocerca volvulus	Cathepsin L homolog	0.0039	0.0322	0.1063
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0014	0.0049	0.0043
Onchocerca volvulus	Cathepsin F homolog	0.0039	0.0322	0.1063
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.0832	0.0797
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0738	0.0738
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0411	0.0364
Schistosoma mansoni	cathepsin F (C01 family)	0.0039	0.0322	0.0322
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0189	0.0183
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0116	0.0103
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.026	0.0829
Plasmodium falciparum	carbonic anhydrase	0.0499	0.5369	0.8101
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0026	0.0182	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0017
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.026	0.0829
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0017
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0014	0.0049	0.0147
Trypanosoma brucei	carbonic anhydrase-like protein	0.0921	1	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0182	0.0176
Trichomonas vaginalis	malate dehydrogenase, putative	0.0128	0.1307	0.4202
Echinococcus granulosus	lamin dm0	0.0026	0.0189	0.0189
Schistosoma mansoni	apoferritin-2	0.001	0.0003	0.0003
Brugia malayi	Flap endonuclease-1	0.0026	0.0181	0.0175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0116	0.0103
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0275	0.0275
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0014	0.0049	0.0147
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0023	0.0023
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0023	0.0017
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0049	0.0043
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.0322	0.0316
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0738	0.0738
Schistosoma mansoni	cpg binding protein	0.0032	0.0253	0.0253
Echinococcus multilocularis	carbonic anhydrase	0.0499	0.5369	0.5369
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0049	0.0147
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0023	0.0017
Leishmania major	cathepsin L-like protease	0.0085	0.0832	0.0787
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0322	0.0316
Leishmania major	cathepsin L-like protease	0.0085	0.0832	0.0787
Schistosoma mansoni	hypothetical protein	0.0499	0.5369	0.5369
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0049	0.001
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0116	0.0103
Echinococcus multilocularis	cysteine protease	0.0039	0.0322	0.0322
Entamoeba histolytica	malate dehydrogenase,cytoplasmic, putative	0.0292	0.3106	0.4655
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0116	0.011
Leishmania major	cathepsin L-like protease	0.0039	0.0322	0.0274
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0322	0.0316
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0014	0.0049	0.0147
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0039	0.0322	0.1027
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0023	0.0023
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0738	0.0738
Plasmodium vivax	vivapain-2	0.0039	0.0322	0.0431
Loa Loa (eye worm)	ctsf protein	0.0039	0.0322	0.0316
Plasmodium vivax	lactate dehydrogenase	0.0612	0.6616	1
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0014	0.0049	0.0049
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0292	0.3106	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.0832	0.0797
Onchocerca volvulus		0.0014	0.0049	0.0091
Echinococcus multilocularis	smad	0.001	0.0006	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0116	0.0365
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0411	0.1314
Loa Loa (eye worm)	hypothetical protein	0.0499	0.5369	0.5366
Toxoplasma gondii	hypothetical protein	0.0499	0.5369	0.8101
Onchocerca volvulus		0.0268	0.2834	1
Trypanosoma brucei	glycosomal malate dehydrogenase	0.0284	0.302	0.2986
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0023	0.0023
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.026	0.0829
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.0832	0.0797
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0049	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0023	0.0017
Brugia malayi	MH2 domain containing protein	0.0144	0.148	0.1475
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0023	0.0023
Schistosoma mansoni	smad1 5 8 and	0.001	0.0006	0.0006
Brugia malayi	RNA binding protein	0.0076	0.0738	0.0732
Echinococcus multilocularis	tumor protein p63	0.0408	0.4376	0.4376
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0292	0.3106	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0281	0.0275
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0023	0.0017
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0411	0.0364
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0411	0.1314
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0023	0.0017
Mycobacterium tuberculosis	Probable malate dehydrogenase Mdh	0.0292	0.3106	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0023	0.0017
Schistosoma mansoni	hypothetical protein	0.0018	0.0093	0.0093
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0921	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0176
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0181	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0023	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0281	0.0275
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0514	0.0509
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0023	0.0017
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0023	0.0023
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0023	0.0023
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Echinococcus multilocularis	carbonic anhydrase II	0.0921	1	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0049	0.0043
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0181	0.0181
Mycobacterium ulcerans	malate dehydrogenase	0.0292	0.3106	1
Echinococcus multilocularis	cysteine protease	0.0039	0.0322	0.0322
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0292	0.3106	0.308
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0049	0.0043
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.002	0.0116	0.0116
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0049	0.0147
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0181	0.0216
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0014	0.0049	0.0043
Onchocerca volvulus		0.0014	0.0049	0.0091
Echinococcus granulosus	GPCR family 2	0.0018	0.0093	0.0093
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0023	0.0023
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0014	0.0049	0.0147
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0023	0.0023
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0038	0.0038
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0023	0.0017
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0292	0.3106	0.3106
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0014	0.0049	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0023	0.0017
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0093	0.0087
Trypanosoma brucei	cytosolic malate dehydrogenase	0.0292	0.3106	0.3072
Brugia malayi	cathepsin L-like precursor	0.0026	0.0182	0.0176
Echinococcus granulosus	cathepsin l1	0.0039	0.0322	0.0322
Echinococcus multilocularis	musashi	0.0026	0.0189	0.0189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Onchocerca volvulus		0.0034	0.0275	0.0896
Leishmania major	cathepsin L-like protease	0.0039	0.0322	0.0274
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0499	0.5369	0.5366
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0499	0.5369	0.5366
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0319	0.0314
Schistosoma mansoni	hypothetical protein	0.0461	0.4954	0.4954
Leishmania major	cathepsin L-like protease	0.0039	0.0322	0.0274
Echinococcus granulosus	lactate dehydrogenase protein	0.0612	0.6616	0.6616
Onchocerca volvulus		0.0039	0.0322	0.1063
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0921	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0023	0.0023
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0013	0.0038	0.0032
Onchocerca volvulus		0.0026	0.0189	0.0589
Onchocerca volvulus		0.0047	0.0411	0.1379
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0189	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0281	0.0275
Leishmania major	mitochondrial malate dehydrogenase	0.0284	0.302	0.2986
Echinococcus granulosus	carbonic anhydrase	0.0499	0.5369	0.5369
Brugia malayi	intermediate filament protein	0.0026	0.0189	0.0183
Schistosoma mansoni	malate dehydrogenase	0.0292	0.3106	0.3106
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0023	0.0017
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0014	0.0049	0.0147
Plasmodium vivax	vivapain-2	0.0039	0.0322	0.0431
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0275	0.0344
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0023	0.0017
Echinococcus multilocularis	carbonic anhydrase	0.0499	0.5369	0.5369
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0738	0.0738
Onchocerca volvulus		0.0039	0.0322	0.1063
Schistosoma mansoni	apoferritin-2	0.001	0.0003	0.0003
Echinococcus granulosus	cathepsin L	0.002	0.0116	0.0116
Trypanosoma cruzi	malate dehydrogenase, putative	0.0264	0.279	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0411	0.0405
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.148	0.1475
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0023	0.0017
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0093	0.0093
Onchocerca volvulus		0.0039	0.0322	0.1063
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0023	0.0023
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0284	0.302	0.2993
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0023	0.0023
Leishmania major	cysteine peptidase A (CPA)	0.0039	0.0322	0.0274
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.148	0.1475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Leishmania major	cathepsin L-like protease	0.0085	0.0832	0.0787
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0023	0.0023
Loa Loa (eye worm)	cysteine protease	0.0039	0.0322	0.0316
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0411	0.1314
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0411	0.0364
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0023	0.0017
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0049	0.0147
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0487	0.045
Trichomonas vaginalis	malate dehydrogenase, putative	0.0292	0.3106	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0023	0.0017
Entamoeba histolytica	cysteine proteinase 2	0.002	0.0116	0.0103
Entamoeba histolytica	cysteine proteinase 1, putative	0.002	0.0116	0.0103
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0411	0.1314
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0411	0.1314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0182	0.0576
Echinococcus granulosus	L lactate dehydrogenase B chain	0.0612	0.6616	0.6616
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0023	0.0023
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0014	0.0049	0.001
Entamoeba histolytica	cysteine protease, putative	0.002	0.0116	0.0103
Trypanosoma cruzi	cysteine protease, putative	0.002	0.0116	0.0078
Schistosoma mansoni	hypothetical protein	0.0018	0.0093	0.0093
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0023	0.0023
Brugia malayi	nuclear hormone receptor	0.0011	0.0023	0.0017
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0514	0.0509
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0093	0.0087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0039	0.0322	0.1027
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0013	0.0038	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0038	0.0032
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0049	0.0147
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0049	0.0147
Giardia lamblia	Malate dehydrogenase	0.0292	0.3106	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.0832	0.0787
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.0322	0.0416
Echinococcus multilocularis	lamin dm0	0.0026	0.0189	0.0189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0322	0.1027
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0292	0.3106	0.3106
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0049	0.0147
Echinococcus multilocularis	lactate dehydrogenase a	0.0612	0.6616	0.6616
Loa Loa (eye worm)	hypothetical protein	0.006	0.0554	0.0548
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.002	0.0116	0.0078
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0014	0.0049	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0411	0.0405

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.01 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.0135 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	0.1122 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1476836

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1458796