Detailed information for compound 1462966

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.374 | Formula: C20H20F3NO
  • H donors: 1 H acceptors: 0 LogP: 5.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1cc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3)cc(c1)c1ccccc1)(F)F
  • InChi: 1S/C20H20F3NO/c21-20(22,23)15-8-14(13-4-2-1-3-5-13)9-18(10-15)25-19-11-16-6-7-17(12-19)24-16/h1-5,8-10,16-17,19,24H,6-7,11-12H2/t16-,17+,19-
  • InChiKey: NAZAMXVJDAUZNQ-IZZQQSIFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.0363 0.6
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.013 0.0332 0.0332
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0009 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0062 0.0062
Entamoeba histolytica vacuolar protein sorting 26 0.0066 0.016 1
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0292 0.0762 0.0762
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0009 0.0009
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.084 0.222 1
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0605 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0062 0.0062
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0002 0.0002
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0392 0.1028 0.1028
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0066 0.016 0.016
Brugia malayi GNT-I family protein 0.0109 0.0276 0.0276
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0066 0.016 0.016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0103 0.0103
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0022 0.0045 0.248
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0162 0.0417 0.1876
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0172 0.3573
Loa Loa (eye worm) hypothetical protein 0.0292 0.0762 0.0762
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0016 0.0028 0.148
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0009 0.0009
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0117 0.0117
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0066 0.016 0.016
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0022 0.0045 0.581
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0024 0.0049 0.101
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0087 0.1434
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.0762 0.0762
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0109 0.0276 0.0276
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0109 0.0276 0.0276
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0022 0.0045 0.248
Brugia malayi regulator of G-protein signaling egl-10 0.0008 0.0006 0.0006
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0117 0.0117
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0276 0.0276
Plasmodium falciparum histone acetyltransferase GCN5 0.0035 0.0078 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0605 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0022 0.0045 0.0933
Entamoeba histolytica hypothetical protein 0.0032 0.0071 0.4423
Toxoplasma gondii type I fatty acid synthase, putative 0.0016 0.0028 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Echinococcus granulosus o acyltransferase membrane bound domain 0.0066 0.016 0.016
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0117 0.0117
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0022 0.0045 0.248
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0066 0.016 0.016
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0117 0.0117
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0098 0.0098
Onchocerca volvulus Fatty acid synthase homolog 0.004 0.0093 0.0417
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0009 0.0009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0022 0.0045 0.0933
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0041 0.0041
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0006 0.0006
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0066 0.016 0.016
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0066 0.016 0.016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0018 0.0033 0.069
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0062 0.0062
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0015 0.0024 0.0107
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0037 0.0084 0.0377
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0117 0.0117
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0066 0.016 0.016
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0066 0.016 0.016
Brugia malayi ecdysteroid receptor 0.0009 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0109 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0063 0.0152 0.0152
Mycobacterium ulcerans fatty acid synthase Fas 0.0007 0.0004 0.0079
Giardia lamblia Histone acetyltransferase GCN5 0.0035 0.0078 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0009 0.0009
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0007 0.0003 0.0014
Echinococcus granulosus geminin 0.0348 0.0911 0.0911
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0009 0.0009
Brugia malayi MBOAT family protein 0.0066 0.016 0.016
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0066 0.016 0.016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0117 0.0117
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0009 0.0009 0.0366
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0029 0.0062 0.0062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0071 0.0071
Leishmania major glycerol uptake protein, putative 0.0066 0.016 0.0722
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0006 0.0006
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.084 0.222 1
Brugia malayi DIX domain containing protein 0.0008 0.0006 0.0006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0127 0.0322 0.0322
Brugia malayi nuclear receptor NHR-88 0.0009 0.0009 0.0009
Schistosoma mansoni dishevelled 0.0008 0.0006 0.0006
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0117 0.0117
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0013 0.0019 0.0949
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0038 0.0087 0.0391
Brugia malayi diacylglycerol acyltransferase family protein 0.084 0.222 0.222
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0022 0.0043 0.2371
Leishmania major hypothetical protein, conserved 0.0066 0.016 0.0722
Loa Loa (eye worm) hypothetical protein 0.0066 0.016 0.016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0009 0.0009
Mycobacterium ulcerans polyketide synthase MbtD 0.0007 0.0003 0.007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0009 0.0009
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0018 0.0033 0.069
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0009 0.0009
Trypanosoma cruzi GUP1, putative 0.0066 0.016 0.0722
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0605 1
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0186 0.048 0.048
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0172 0.0773
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0117 0.0117
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0172 0.3573
Mycobacterium ulcerans thioesterase TesA 0.0019 0.0035 0.0725
Schistosoma mansoni dep domain containing protein 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0066 0.016 0.016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0009 0.0009
Onchocerca volvulus 0.0008 0.0006 0.0027
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0066 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.016 0.2648
Loa Loa (eye worm) hypothetical protein 0.0063 0.0152 0.0152
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0009 0.0009
Brugia malayi Hhat protein 0.0066 0.016 0.016
Toxoplasma gondii type I fatty acid synthase, putative 0.0024 0.0049 0.0219
Brugia malayi Methyltransferase-like protein 4 0.0007 0.0003 0.0003
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0008 0.0006 0.0151
Schistosoma mansoni hypothetical protein 0.0348 0.0911 0.0911
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0009 0.0009
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0008 0.0006 0.0027
Echinococcus granulosus o acyltransferase membrane bound domain 0.0066 0.016 0.016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0009 0.0009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0009 0.0041
Toxoplasma gondii dgat2l1-prov protein 0.084 0.222 1
Brugia malayi MBOAT family protein 0.0066 0.016 0.016
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0022 0.0043 0.2371
Onchocerca volvulus 0.084 0.222 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0009 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0047
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0006 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0103 0.0103
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.3762 1 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0006
Echinococcus granulosus Pleckstrin G protein interacting region 0.0008 0.0006 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0066 0.016 0.016
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0011 0.0015 0.0069
Trypanosoma cruzi hypothetical protein 0.0006 0 0.0001
Toxoplasma gondii diacylglycerol acyltransferase 0.0186 0.048 0.2163
Schistosoma mansoni regulator of G protein signaling 0.0008 0.0006 0.0006
Echinococcus multilocularis cpg binding protein 0.0027 0.0058 0.0058
Loa Loa (eye worm) MBOAT family protein 0.0066 0.016 0.016
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0186 0.048 0.048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0009 0.0009
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0034 0.0074 0.4235
Mycobacterium ulcerans Type I modular polyketide synthase 0.0022 0.0045 0.0933
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0172 0.0172
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0392 0.1028 0.1028
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0066 0.016 0.016
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0392 0.1028 1
Loa Loa (eye worm) hhat protein 0.0066 0.016 0.016
Schistosoma mansoni cpg binding protein 0.0026 0.0054 0.0054
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0186 0.048 0.2163
Echinococcus granulosus mixed lineage leukemia protein mll 0.0006 0.0002 0.0002
Brugia malayi diacylglycerol acyltransferase 0.0392 0.1028 0.1028
Leishmania major glycerol uptake protein, putative 0.0066 0.016 0.0722
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0117 0.0117
Plasmodium falciparum amino acid transporter, putative 0.005 0.0117 0.1137
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0002 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0032 0.0071 0.4423
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0009 0.0009
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0117 0.0117
Brugia malayi MBOAT family protein 0.0066 0.016 0.016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0041 0.0041
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0009 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0009 0.0009
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0041 0.2247
Loa Loa (eye worm) DIX domain-containing protein 0.0008 0.0006 0.0006
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0022 0.0045 0.0933
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.013 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0117
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0034 0.0074 0.4235
Echinococcus granulosus microtubule associated protein 2 0.0623 0.1643 0.1643
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.016 0.2648
Schistosoma mansoni hypothetical protein 0.0369 0.0968 0.0968
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.0084
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0186 0.048 0.2163
Onchocerca volvulus 0.0026 0.0054 0.0243
Echinococcus granulosus dnaJ subfamily B 0.0369 0.0968 0.0968
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0024 0.0049 0.6337
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0186 0.048 0.2163
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0001 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0009 0.0009
Schistosoma mansoni methyltransferase-related 0.0007 0.0003 0.0003
Leishmania major glycerol uptake protein, putative 0.0066 0.016 0.0722
Loa Loa (eye worm) MBOAT family protein 0.0066 0.016 0.016
Schistosoma mansoni hypothetical protein 0.0348 0.0911 0.0911
Trypanosoma cruzi GUP1, putative 0.0066 0.016 0.0722
Brugia malayi hypothetical protein 0.0032 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0019 0.0035 0.4398
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.0762 1
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0605 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0605 1
Onchocerca volvulus 0.0066 0.016 0.0722
Schistosoma mansoni hypothetical protein 0.0029 0.0062 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0009 0.0009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0001 0.0008
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0001 0.0008
Echinococcus granulosus GPCR family 2 0.0029 0.0062 0.0062
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0009 0.0009
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0186 0.048 0.048
Plasmodium vivax hypothetical protein, conserved 0.005 0.0117 0.1137
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0117
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0066 0.016 1
Echinococcus multilocularis GPCR, family 2 0.0029 0.0062 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0103 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0092 0.0229 0.0229
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0001 0.0008
Loa Loa (eye worm) MBOAT family protein 0.0066 0.016 0.016
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0007 0.0004 0.0046
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0066 0.016 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0117
Echinococcus granulosus cpg binding protein 0.0027 0.0058 0.0058
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0186 0.048 0.2163
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0071 0.0071
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0024 0.0049 0.27
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.3762 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0605 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0009 0.0009
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0117 0.0527
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0006 0.0006
Brugia malayi hypothetical protein 0.005 0.0117 0.0117
Brugia malayi N-terminal motif family protein 0.0162 0.0417 0.0417
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0006 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0103 0.0103
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0172 0.0172
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0006 0.0006
Mycobacterium ulcerans polyketide synthase Pks9 0.0015 0.0025 0.0511
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0009 0.0009
Leishmania major diacylglycerol acyltransferase, putative 0.084 0.222 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0103 0.0103
Schistosoma mansoni microtubule-associated protein tau 0.0623 0.1643 0.1643
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0117 0.0117
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0117 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0009 0.0009
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0049 0.101
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.0124 0.0559
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0022 0.0045 0.0045
Schistosoma mansoni dishevelled 0.0008 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0605 1
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0605 1
Toxoplasma gondii hypothetical protein 0.005 0.0117 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0029 0.0062 0.0062
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0392 0.1028 0.4633
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0066 0.016 0.016
Schistosoma mansoni zinc finger protein 0.0066 0.016 0.016
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.0762 0.0762
Entamoeba histolytica hypothetical protein 0.0032 0.0071 0.4423
Schistosoma mansoni sterol O-acyltransferase 1 0.0066 0.016 0.016
Leishmania major glycerol uptake protein, putative 0.0066 0.016 0.0722
Onchocerca volvulus 0.0021 0.0041 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Echinococcus multilocularis microtubule associated protein 2 0.0623 0.1643 0.1643
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0066 0.016 0.016
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0006 0.0006
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0066 0.016 0.016
Trypanosoma cruzi glycerol uptake protein, putative 0.0066 0.016 0.0722
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0009 0.0009
Leishmania major diacylglycerol acyltransferase, putative 0.0186 0.048 0.2163
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0024 0.0049 0.27
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0015 0.0025 0.0511
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0066 0.016 0.016
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0 0.0001
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0006 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0172 0.3573
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0024 0.0049 0.27
Brugia malayi Calcitonin receptor-like protein seb-1 0.0092 0.0229 0.0229
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0117 0.0117
Brugia malayi hypothetical protein 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0018 0.0034 0.1833
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0117
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0117 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0009 0.0009
Loa Loa (eye worm) fatty acid synthase 0.0022 0.0044 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0103 0.0103
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0009 0.0009
Brugia malayi CXXC zinc finger family protein 0.0026 0.0054 0.0054
Echinococcus granulosus serotonin transporter 0.0292 0.0762 0.0762
Brugia malayi Pax transcription factor protein 2 0.0234 0.0608 0.0608
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0062 0.0062
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0009 0.0009
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0186 0.048 0.2163
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0062 0.0062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0054 0.0054
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0117 1
Loa Loa (eye worm) hypothetical protein 0.3762 1 1
Loa Loa (eye worm) hypothetical protein 0.0326 0.0853 0.0853
Brugia malayi steroid hormone receptor 0.0009 0.0009 0.0009
Schistosoma mansoni cpg binding protein 0.0027 0.0058 0.0058
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0009 0.0009
Echinococcus multilocularis sterol O acyltransferase 1 0.0066 0.016 0.016
Loa Loa (eye worm) hhat protein 0.0066 0.016 0.016
Toxoplasma gondii hypothetical protein 0.0091 0.0227 0.1023
Trichomonas vaginalis transmembrane protein nessy, putative 0.0066 0.016 0.2648
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0092 0.0229 0.0229
Schistosoma mansoni z-protein (S1r protein) 0.0008 0.0006 0.0006
Loa Loa (eye worm) serotonin transporter b 0.0292 0.0762 0.0762
Loa Loa (eye worm) acyl carrier protein 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0018
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0008 0.0006 0.0006
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.084 0.222 1
Echinococcus multilocularis geminin 0.0348 0.0911 0.0911
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0186 0.048 0.2163
Onchocerca volvulus 0.005 0.0117 0.0526
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0172 1
Onchocerca volvulus 0.005 0.0117 0.0526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Trypanosoma cruzi hypothetical protein 0.0006 0 0.0001
Brugia malayi hypothetical protein 0.0008 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0006 0 0.5
Trichomonas vaginalis helicase, putative 0.0006 0.0001 0.0008
Brugia malayi nuclear hormone receptor 0.0009 0.0009 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0009 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0001 0.0008
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0186 0.048 0.2163
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.3762 1 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0117 0.0117
Entamoeba histolytica hypothetical protein 0.0066 0.016 1
Onchocerca volvulus 0.0234 0.0608 0.2739
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0009 0.0009
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0008 0.0006 0.0006
Echinococcus granulosus o acyltransferase membrane bound domain 0.0066 0.016 0.016
Brugia malayi MBOAT family protein 0.0066 0.016 0.016
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0117 0.0117
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0009 0.0009
Toxoplasma gondii hypothetical protein 0.005 0.0117 0.0527
Loa Loa (eye worm) acetyltransferase 0.013 0.0332 0.0332
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0009 0.0009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0009 0.0009
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.0608 0.0608
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0117 0.0117
Mycobacterium leprae Polyketide synthase Pks13 0.0034 0.0074 1
Schistosoma mansoni cpg binding protein 0.0027 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.016 0.2648
Schistosoma mansoni hypothetical protein 0.0032 0.0071 0.0071
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0392 0.1028 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0066 0.016 0.0722
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0066 0.016 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0103 0.0103
Entamoeba histolytica hypothetical protein 0.0032 0.0071 0.4423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0009 0.0009
Trypanosoma brucei glycerol uptake protein, putative 0.0066 0.016 0.0722
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0066 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0085
Mycobacterium tuberculosis Probable thioesterase TesA 0.0019 0.0035 0.1888
Onchocerca volvulus 0.005 0.0117 0.0526
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0066 0.016 0.016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0002 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0009 0.0009
Plasmodium vivax amine transporter, putative 0.005 0.0117 0.1137
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0018 0.0033 0.4155
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0038 0.0087 0.0391
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0117
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0062 0.0062
Trichomonas vaginalis porcupine, putative 0.0066 0.016 0.2648
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0024 0.0049 0.6337
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0117 0.0527
Loa Loa (eye worm) hypothetical protein 0.0092 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) diacylglycerol acyltransferase 0.084 0.222 0.222
Onchocerca volvulus 0.0292 0.0762 0.3434
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0029 0.0062 0.0062
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0007 0.0003 0.0022
Mycobacterium ulcerans thioesterase 0.0019 0.0035 0.0725
Echinococcus multilocularis dnaJ subfamily B 0.0369 0.0968 0.0968
Echinococcus granulosus sterol O acyltransferase 1 0.0066 0.016 0.016
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0022 0.0045 0.581
Echinococcus granulosus histone acetyltransferase KAT2B 0.0038 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0066 0.016 0.016
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0117 0.0117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0001 0.0008
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0009 0.0041
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0117 0.0117
Toxoplasma gondii hypothetical protein 0.0066 0.016 0.0722
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0006 0.0002 0.0002
Onchocerca volvulus 0.0039 0.0089 0.0401
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0006 0.0006
Leishmania major glycerol uptake protein, putative 0.0066 0.016 0.0722
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.0762 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Mycobacterium ulcerans hypothetical protein 0.0186 0.048 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.0417 0.0417
Brugia malayi Glycosylation related protein 12, isoform 0.0037 0.0084 0.0084
Brugia malayi MBOAT family protein 0.0066 0.016 0.016
Mycobacterium ulcerans polyketide synthase 0.0022 0.0045 0.0933
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0172 0.0172
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0038 0.0087 0.1434
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0117 0.0117
Entamoeba histolytica acetyltransferase, GNAT family 0.0035 0.0078 0.4885
Onchocerca volvulus 0.0009 0.0009 0.0041
Plasmodium falciparum transporter, putative 0.005 0.0117 0.1137
Mycobacterium ulcerans polyketide synthase Pks13 0.0034 0.0074 0.1549
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0117 0.0527
Toxoplasma gondii hypothetical protein 0.0008 0.0006 0.0028
Leishmania major diacylglycerol acyltransferase, putative 0.0186 0.048 0.2163
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0001 0.0008
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0392 0.1028 0.1028
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0009 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0055 0.0131 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0001 0.0008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0172 0.0172
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0117 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0109 0.0276 0.0276
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.084 0.222 0.222
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0392 0.1028 0.4633
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0172 0.0773
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0009 0.0009
Brugia malayi acetyltransferase, GNAT family protein 0.013 0.0332 0.0332
Brugia malayi latrophilin 2 splice variant baaae 0.0063 0.0152 0.0152
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0009 0.0009
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0117 0.0117
Trypanosoma cruzi glycerol uptake protein, putative 0.0066 0.016 0.0722
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0117 0.0117
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0015 0.0025 0.2941
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0117 0.0117
Mycobacterium leprae Probable polyketide synthase Pks1 0.0024 0.0049 0.6337
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0117
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.0762 0.0762
Mycobacterium ulcerans polyketide synthase 0.0024 0.0049 0.101
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0038 0.0087 0.0845
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0009 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0009 0.0009
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0066 0.016 1
Echinococcus multilocularis serotonin transporter 0.0292 0.0762 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0008
Trypanosoma brucei glycerol uptake protein, putative 0.0066 0.016 0.0722
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0392 0.1028 0.1028
Schistosoma mansoni coup transcription factor 0.0009 0.0009 0.0009
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0006 0.0006

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 891 nM Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation counting ChEMBL. 21112782
IC50 (binding) = 4624 nM Inhibition of [3H]serotonin reuptake at SERT expressed in HEK293 cells scintillation counting ChEMBL. 21112782
IC50 (binding) > 10000 nM Inhibition of [3H]dopamine reuptake at DAT expressed in HEK293 cells scintillation counting ChEMBL. 21112782

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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