Detailed information for compound 1468474

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.427 | Formula: C19H24N5O+
  • H donors: 1 H acceptors: 0 LogP: 2.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[n+]1cccc(c1)COc1ccc(cc1)/C=N/NC(=N)N1CCCC1
  • InChi: 1S/C19H24N5O/c1-23-10-4-5-17(14-23)15-25-18-8-6-16(7-9-18)13-21-22-19(20)24-11-2-3-12-24/h4-10,13-14H,2-3,11-12,15H2,1H3,(H2,20,22)/q+1/b21-13+
  • InChiKey: BMAWRWIFEHASAB-FYJGNVAPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi steroid hormone receptor 0.0031 0.0184 0.0506
Trypanosoma brucei heat shock protein, putative 0.0033 0.021 0.1972
Schistosoma mansoni endoplasmin 0.0033 0.021 0.0248
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.0506
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0598 0.1647
Echinococcus granulosus microtubule associated protein 2 0.0693 0.848 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0632 0.0745
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0044 0.0413
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.848 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0127 0.0811
Onchocerca volvulus Alhambra homolog 0.0029 0.0168 0.0229
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0119 0.5653
Entamoeba histolytica hypothetical protein 0.0036 0.0254 0.357
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0184 0.0184
Echinococcus multilocularis zinc finger protein 0.004 0.0296 0.0296
Echinococcus multilocularis peregrin 0.0034 0.0228 0.0228
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0184 0.0217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0184 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0232 0.0274
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.021 0.0578
Brugia malayi nuclear receptor RXR 0.0016 0.0003 0.0009
Schistosoma mansoni hypothetical protein 0.0042 0.0323 0.0381
Echinococcus granulosus peregrin 0.0034 0.0228 0.0269
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0254 0.0299
Echinococcus multilocularis heat shock protein 0.0033 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0238 0.2775 0.7642
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0632 0.1739
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.1065 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0184 0.0506
Schistosoma mansoni lamin 0.0027 0.014 0.0166
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0156 0.1749 0.2062
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.021 0.1972
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0119 0.0119
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0119 0.014
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0184 0.0217
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0184 0.0217
Schistosoma mansoni heat shock protein 0.0033 0.021 0.0248
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0156 0.1749 0.1749
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0184 0.0217
Echinococcus multilocularis lamin 0.0027 0.014 0.014
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0119 0.1115
Giardia lamblia PHD finger protein 15 0.0029 0.0168 0.1214
Schistosoma mansoni hypothetical protein 0.0031 0.0188 0.0222
Brugia malayi Bromodomain containing protein 0.0077 0.0769 0.2118
Brugia malayi jmjC domain containing protein 0.0025 0.0119 0.0327
Loa Loa (eye worm) MBCTL1 0.0055 0.0484 0.1333
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0184 0.0506
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0184 0.0361
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0632 0.5928
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0003 0.0004
Echinococcus granulosus dna polymerase eta 0.0019 0.0044 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0168 0.0463
Onchocerca volvulus 0.0048 0.0401 0.217
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0371 0.0371
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0184 0.0506
Brugia malayi jmjC domain containing protein 0.0025 0.0119 0.0327
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0184 0.0217
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.104 0.1226
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0632 0.0745
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0484 0.0571
Brugia malayi MH2 domain containing protein 0.012 0.1303 0.3587
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0632 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0484 0.0484
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1303 0.3587
Echinococcus granulosus heat shock protein 0.0033 0.021 0.0248
Brugia malayi hypothetical protein 0.0123 0.1342 0.3696
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0184 0.0184
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0101 0.1065 0.2933
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0598 0.0705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0184 0.0506
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.0506
Schistosoma mansoni zinc finger protein 0.0031 0.0188 0.0222
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0119 0.0327
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0119 0.0327
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0598 0.0705
Trypanosoma brucei heat shock protein, putative 0.0033 0.021 0.1972
Trypanosoma brucei heat shock protein, putative 0.0033 0.021 0.1972
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.1065 0.1256
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0306 0.3632 0.4282
Schistosoma mansoni jumonji domain containing protein 0.0136 0.1502 0.1771
Schistosoma mansoni survival motor neuron protein 0.0048 0.0408 0.0481
Loa Loa (eye worm) hypothetical protein 0.0082 0.0831 0.2288
Brugia malayi ecdysteroid receptor 0.0031 0.0184 0.0506
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0044 0.0044
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.131 0.131
Trichomonas vaginalis heat shock protein, putative 0.002 0.0052 0.0079
Loa Loa (eye worm) hypothetical protein 0.0048 0.0401 0.1105
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0184 0.0217
Brugia malayi hypothetical protein 0.0016 0.0003 0.0009
Schistosoma mansoni zinc finger protein 0.004 0.0296 0.0349
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0371 0.0438
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0184 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0184 0.0506
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0167 0.0197
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0401 0.0401
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0127 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0184 0.0506
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0248 0.0682
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.104 0.1226
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.2165 0.2165
Toxoplasma gondii cathepsin B 0.0101 0.1065 1
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0282 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0232 0.0274
Brugia malayi cathepsin B-like cysteine proteinase 0.0306 0.3632 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.0506
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.021 0.0578
Echinococcus granulosus lamin dm0 0.0027 0.014 0.0166
Brugia malayi hypothetical protein 0.0036 0.0254 0.0699
Echinococcus multilocularis cathepsin b 0.0306 0.3632 0.3632
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0484 0.0571
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0044 0.0052
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0184 0.0217
Trypanosoma brucei heat shock protein, putative 0.0033 0.021 0.1972
Echinococcus multilocularis heat shock protein 90 0.0026 0.0127 0.0127
Echinococcus multilocularis musashi 0.0027 0.014 0.014
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0119 0.0119
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0184 0.0506
Giardia lamblia Cathepsin B precursor 0.0101 0.1065 1
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.021 0.0578
Echinococcus granulosus cathepsin b 0.0306 0.3632 0.4282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.0506
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0043 0.0117
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0127 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0184 0.0506
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.021 0.1972
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0184 0.0506
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0184 0.0184
Entamoeba histolytica hypothetical protein 0.0036 0.0254 0.357
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0121
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.014 0.0387
Echinococcus multilocularis lysine specific demethylase 5A 0.0095 0.0992 0.0992
Brugia malayi photoreceptor-specific nuclear receptor 0.0268 0.3153 0.8682
Plasmodium vivax endoplasmin, putative 0.0033 0.021 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0184 0.0506
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0003 0.0004
Trichomonas vaginalis heat shock protein, putative 0.0033 0.021 0.1626
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0052
Loa Loa (eye worm) hypothetical protein 0.0066 0.0629 0.1732
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0184 0.0506
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0632 0.0632
Leishmania major DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Plasmodium falciparum heat shock protein 90 0.0033 0.021 1
Loa Loa (eye worm) cathepsin B 0.0101 0.1065 0.2933
Loa Loa (eye worm) hypothetical protein 0.0034 0.0232 0.064
Brugia malayi jmjC domain containing protein 0.0156 0.1749 0.4816
Brugia malayi hypothetical protein 0.0016 0.0003 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0184 0.0506
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0558 0.1538
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0127 0.0811
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0119 0.1115
Echinococcus granulosus endoplasmin 0.0026 0.0127 0.015
Giardia lamblia Cathepsin B precursor 0.0101 0.1065 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.3632 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0119 0.0327
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0055 0.0484 0.1333
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0632 0.1739
Leishmania major DNA polymerase eta, putative 0.0019 0.0044 0.0413
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0127 0.5
Loa Loa (eye worm) endoplasmin 0.0033 0.021 0.0578
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0184 0.0184
Echinococcus multilocularis transcription factor eb 0.0108 0.1159 0.1159
Schistosoma mansoni endoplasmin 0.0033 0.021 0.0248
Echinococcus granulosus cathepsin b 0.0306 0.3632 0.4282
Brugia malayi RNA binding protein 0.0064 0.0598 0.1647
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2775 0.3273
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0184 0.0217
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0632 0.5928
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0184 0.0217
Loa Loa (eye worm) hypothetical protein 0.0077 0.0771 0.2123
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0184 0.0506
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0184 0.0217
Loa Loa (eye worm) heat shock protein 90 0.0033 0.021 0.0578
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0401 0.0473
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0044 0.0121
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0127 0.015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0168 0.0198
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0184 0.0184
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0401 0.0401
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0044
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0282 0.0332
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0184 0.0217
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0121
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0184 0.0506
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0632 0.1739
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0168 0.0463
Brugia malayi mbt repeat family protein 0.0048 0.0401 0.1105
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0167 0.0167
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0184 0.0361
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0268 0.3153 0.8682
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0232 0.0274
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0413
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0312 0.0367
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.104 0.1226
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Onchocerca volvulus Huntingtin homolog 0.0123 0.1342 1
Schistosoma mansoni hypothetical protein 0.0029 0.0168 0.0198
Loa Loa (eye worm) hypothetical protein 0.0123 0.1342 0.3696
Echinococcus multilocularis cathepsin b 0.0306 0.3632 0.3632
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0121
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0184 0.0217
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0598 0.1647
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.104 0.2864
Echinococcus granulosus tar DNA binding protein 0.0064 0.0598 0.0705
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.021 0.0578
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0119 0.014
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0184 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0184 0.0506
Loa Loa (eye worm) hypothetical protein 0.0108 0.1152 0.3173
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0484 0.0484
Schistosoma mansoni hypothetical protein 0.0291 0.3448 0.4066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0184 0.0184
Onchocerca volvulus 0.0048 0.0408 0.2226
Plasmodium vivax JmjC domain containing protein 0.0025 0.0119 0.5653
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.0506
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0254 0.0299
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0184 0.0217
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Echinococcus multilocularis geminin 0.017 0.1932 0.1932
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.021 0.0578
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0254 0.0254
Onchocerca volvulus 0.0031 0.0184 0.0361
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.848 0.848
Echinococcus granulosus lamin 0.0027 0.014 0.0166
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0003 0.0009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.3632 0.4282
Loa Loa (eye worm) hypothetical protein 0.0123 0.1342 0.3696
Echinococcus granulosus geminin 0.017 0.1932 0.2279
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0108 0.1152 0.3173
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0184 0.0506
Brugia malayi TAR-binding protein 0.0064 0.0598 0.1647
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0168 0.1577
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Schistosoma mansoni hypothetical protein 0.0048 0.0408 0.0481
Brugia malayi PHD-finger family protein 0.005 0.0431 0.1186
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0044 0.347
Brugia malayi hypothetical protein 0.0238 0.2775 0.7642
Schistosoma mansoni lamin 0.0027 0.014 0.0166
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0598 0.0705
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0184 0.0217
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0127 0.1191
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0108 0.1159 0.3191
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Brugia malayi jmjC domain containing protein 0.0099 0.104 0.2864
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0598 0.0705
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0232 0.0274
Brugia malayi mbt repeat family protein 0.0048 0.0401 0.1105
Giardia lamblia Grp94/Hsp90 0.0026 0.0127 0.0811
Brugia malayi intermediate filament protein 0.0027 0.014 0.0387
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0401 0.0473
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0168 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0598 0.0705
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0184 0.0361
Trypanosoma brucei heat shock protein, putative 0.0033 0.021 0.1972
Trypanosoma brucei heat shock protein, putative 0.0033 0.021 0.1972
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0184 0.0217
Onchocerca volvulus Huntingtin homolog 0.0123 0.1342 1
Leishmania major hypothetical protein, conserved 0.0025 0.0119 0.1115
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.014 0.0387
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.021 0.1972
Brugia malayi jmjC domain containing protein 0.0025 0.0119 0.0327
Loa Loa (eye worm) intermediate filament protein 0.0027 0.014 0.0387
Schistosoma mansoni heat shock protein 0.0033 0.021 0.0248
Schistosoma mansoni hypothetical protein 0.017 0.1932 0.2279
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0371 0.0438
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0127 0.0349
Loa Loa (eye worm) hypothetical protein 0.0143 0.1589 0.4374
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0184 0.0506
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0044 0.0413
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0119 0.014
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0184 0.0217
Schistosoma mansoni DNA polymerase eta 0.0019 0.0044 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0184 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0312 0.0312
Brugia malayi heat shock protein 90 0.0033 0.021 0.0578
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0119 0.0327
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0484 0.1333
Echinococcus granulosus intermediate filament protein 0.0027 0.014 0.0166
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0119 0.014
Echinococcus multilocularis dna polymerase eta 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.0506
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0401 0.0473
Echinococcus multilocularis lamin dm0 0.0027 0.014 0.014
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2775 0.2775
Giardia lamblia Cathepsin B precursor 0.0101 0.1065 1
Brugia malayi nuclear receptor NHR-88 0.0031 0.0184 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0119 0.014
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.021 0.1972
Plasmodium falciparum endoplasmin, putative 0.002 0.0052 0.2478
Trypanosoma brucei heat shock protein, putative 0.0033 0.021 0.1972
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.021 0.2827
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0127 0.0811
Loa Loa (eye worm) RNA binding protein 0.0064 0.0598 0.1647
Trypanosoma cruzi ISWI complex protein 0.0031 0.0188 0.0517
Brugia malayi Bromodomain containing protein 0.0151 0.1697 0.4672
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0709 0.0836
Trypanosoma brucei heat shock protein, putative 0.0033 0.021 0.1972
Brugia malayi PHD-finger family protein 0.0029 0.0168 0.0463
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.0506
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0101 0.1065 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0121
Brugia malayi jmjC domain containing protein 0.0025 0.0119 0.0327
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0127 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0184 0.0506
Schistosoma mansoni bromodomain containing protein 0.0128 0.1401 0.1652
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.3632 0.4282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0327
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0119 0.014
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0127 0.0811
Trypanosoma brucei unspecified product 0.0019 0.0044 0.0413
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0232 0.0274
Echinococcus multilocularis endoplasmin 0.0026 0.0127 0.0127
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0119 0.0119
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0484 0.0571
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0709 0.0709
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0408 0.1123
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.021 0.2827
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0401 0.217
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0127 0.0349
Entamoeba histolytica hypothetical protein 0.0036 0.0254 0.357
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.131 0.1545
Trypanosoma brucei ISWI complex protein 0.0031 0.0188 0.1764
Echinococcus granulosus transcription factor eb 0.0108 0.1159 0.1366
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0168 0.7995
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0184 0.0217
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0044 0.0121
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0168 0.1577
Schistosoma mansoni coup transcription factor 0.0031 0.0184 0.0217
Toxoplasma gondii heat shock protein HSP90 0.0033 0.021 0.1972
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.021 0.1626
Leishmania major hypothetical protein, conserved 0.0031 0.0188 0.1764
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0184 0.0506
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0387
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Plasmodium vivax heat shock protein 86, putative 0.0033 0.021 1
Brugia malayi nuclear hormone receptor 0.0031 0.0184 0.0506
Trichomonas vaginalis endoplasmin, putative 0.002 0.0052 0.0079
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0184 0.0217
Brugia malayi Endoplasmin precursor 0.0033 0.021 0.0578
Brugia malayi Bromodomain containing protein 0.0034 0.0228 0.0627
Treponema pallidum heat shock protein 90 0.0026 0.0127 0.5
Echinococcus multilocularis heat shock protein 90 0.0033 0.021 0.021
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0401 0.1105
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0044 0.347
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0121
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0184 0.0506
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0003 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Echinococcus granulosus heat shock protein 90 0.0033 0.021 0.0248
Schistosoma mansoni intermediate filament proteins 0.0027 0.014 0.0166
Schistosoma mansoni hypothetical protein 0.0036 0.0254 0.0299
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0119 0.014
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0306 0.3632 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0401 0.0473
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0632 0.1739
Echinococcus granulosus zinc finger protein 0.004 0.0296 0.0349
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0184 0.0217
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0044 0.0052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.3632 0.4282
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0598 0.1647
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0121
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0184 0.0506
Schistosoma mansoni hypothetical protein 0.017 0.1932 0.2279
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0323 0.0889
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0184 0.0217
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1303 0.3587
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0401 0.0473
Trypanosoma brucei cysteine peptidase C (CPC) 0.0101 0.1065 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0119 0.0327
Echinococcus granulosus phd:f box containing protein 0.0025 0.0119 0.014
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.2165 0.2553
Echinococcus granulosus heat shock protein 90 0.0026 0.0127 0.015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0413
Plasmodium falciparum phd finger protein, putative 0.0029 0.0168 0.7995
Echinococcus granulosus dna polymerase kappa 0.0019 0.0044 0.0052
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0232 0.0274
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0119 0.014
Trypanosoma cruzi ISWI complex protein 0.0031 0.0188 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0184 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0413
Entamoeba histolytica hypothetical protein 0.0036 0.0254 0.357
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0413
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0232 0.0232
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0003 0.0009
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0327
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0119 0.0119
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0119 0.1115
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0086 0.0879 0.2421
Leishmania major heat shock protein 83-1 0.0033 0.021 0.1972

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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