TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 508.997 | Formula: C17H19ClN3O7S3-
H donors: 2 H acceptors: 8 LogP: 1.92 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: CCN(C1CC(C)S(=O)(=O)c2c1cc(s2)S(=O)(=O)N)C(=O)c1cccc(n1)C(=O)O.[Cl-]
InChi: 1S/C17H19N3O7S3.ClH/c1-3-20(15(21)11-5-4-6-12(19-11)16(22)23)13-7-9(2)29(24,25)17-10(13)8-14(28-17)30(18,26)27;/h4-6,8-9,13H,3,7H2,1-2H3,(H,22,23)(H2,18,26,27);1H/p-1
InChiKey: AHNZRIFOIBXRRK-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0404	0.1124	0.1122
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0021	0.0036	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0404	0.1124	0.1124
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.006	0.006
Brugia malayi	hypothetical protein	0.0187	0.0505	0.0504
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0021	0.0036	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0404	0.1124	0.1122
Onchocerca volvulus	Myosin regulatory light chain 2 homolog	0.005	0.0119	0.0058
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0404	0.1124	0.1122
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0137	0.1885
Echinococcus granulosus	glycine receptor subunit beta	0.0404	0.1124	0.3218
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.021	0.0572	1
Onchocerca volvulus		0.0218	0.0594	0.0537
Echinococcus granulosus	nAChR subunit	0.0218	0.0594	0.1699
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0187	0.0505	0.1444
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Schistosoma mansoni	cpg binding protein	0.0032	0.0066	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0218	0.0594	0.0593
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.021	0.0572	0.1635
Loa Loa (eye worm)	CYP4Cod1	0.003	0.006	0.006
Schistosoma mansoni	cpg binding protein	0.0032	0.0066	0.0087
Schistosoma mansoni	sodium/chloride dependent transporter	0.021	0.0572	0.1554
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0036	0.0034
Schistosoma mansoni	nAChR subunit	0.0404	0.1124	0.3152
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0187	0.0505	0.1444
Onchocerca volvulus		0.0187	0.0505	0.0447
Brugia malayi	Myosin regulatory light chain 1	0.005	0.0119	0.0117
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0979	0.2754	0.7891
Schistosoma mansoni	nAChR subunit	0.0404	0.1124	0.3152
Schistosoma mansoni	nAChR subunit	0.0404	0.1124	0.3152
Loa Loa (eye worm)	myosin Light Chain family member	0.005	0.0119	0.0119
Loa Loa (eye worm)	blistered cuticle protein 3	0.3532	1	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.021	0.0572	0.1635
Brugia malayi	Neuronal calcium sensor family protein 1	0.005	0.0119	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Echinococcus multilocularis		0.0021	0.0036	0.0096
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0979	0.2754	0.2754
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1238	0.3489	0.3488
Brugia malayi	RasGEF domain containing protein	0.005	0.0119	0.0117
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0021	0.0036	0.5
Schistosoma mansoni	neurotransmitter gated ion channel	0.0218	0.0594	0.1618
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0404	0.1124	0.3152
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0187	0.0505	0.0505
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0218	0.0594	0.1618
Loa Loa (eye worm)	hypothetical protein	0.1238	0.3489	0.3489
Trypanosoma cruzi	centrin, putative	0.005	0.0119	0.0132
Echinococcus granulosus	serotonin transporter	0.1238	0.3489	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.021	0.0572	0.057
Plasmodium falciparum	amino acid transporter, putative	0.021	0.0572	1
Onchocerca volvulus		0.0187	0.0505	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0979	0.2754	0.2754
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0404	0.1124	0.3218
Echinococcus granulosus	Myosin regulatory light chain	0.005	0.0119	0.0334
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0187	0.0505	0.1444
Brugia malayi	hypothetical protein	0.0187	0.0505	0.0504
Plasmodium falciparum	transporter, putative	0.021	0.0572	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0021	0.0036	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.021	0.0572	0.1554
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.003	0.006	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.021	0.0572	1
Entamoeba histolytica	hypothetical protein	0.0218	0.0594	0.2849
Onchocerca volvulus		0.0218	0.0594	0.0537
Loa Loa (eye worm)	hypothetical protein	0.005	0.0119	0.0119
Brugia malayi	Probable myosin regulatory light chain	0.005	0.0119	0.0117
Schistosoma mansoni	acetylcholine receptor-related	0.0187	0.0505	0.1361
Trypanosoma cruzi	cytochrome P450, putative	0.003	0.006	0.0038
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.021	0.0572	0.1554
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0404	0.1124	0.3152
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0404	0.1124	0.1122
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0404	0.1124	0.3218
Onchocerca volvulus		0.0404	0.1124	0.107
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.021	0.0572	0.1554
Onchocerca volvulus		0.0404	0.1124	0.107
Toxoplasma gondii	calcium binding protein precursor, putative	0.005	0.0119	0.1552
Brugia malayi	Cation transporter family protein	0.0404	0.1124	0.1122
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Trypanosoma cruzi	cytochrome P450, putative	0.003	0.006	0.0038
Echinococcus multilocularis	Myosin regulatory light chain	0.005	0.0119	0.0334
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0187	0.0505	0.0505
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.021	0.0572	0.057
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.021	0.0572	0.1554
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.006	0.006
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0021	0.0036	0.5
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0404	0.1124	0.3218
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0404	0.1124	0.1122
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0404	0.1124	0.1124
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0979	0.2754	0.7891
Onchocerca volvulus		0.0404	0.1124	0.107
Loa Loa (eye worm)	serotonin transporter b	0.1238	0.3489	0.3489
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0061	0.0061
Mycobacterium leprae	putative cytochrome p450	0.0021	0.0036	0.5
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0187	0.0505	0.0504
Onchocerca volvulus		0.021	0.0572	0.0515
Loa Loa (eye worm)	hypothetical protein	0.1238	0.3489	0.3489
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0404	0.1124	0.3218
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0002	0.0002
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0021	0.0036	0.5
Toxoplasma gondii	EF hand domain-containing protein	0.005	0.0119	0.1552
Brugia malayi	Cation transporter family protein	0.0404	0.1124	0.1122
Loa Loa (eye worm)	hypothetical protein	0.005	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0021	0.0036	0.5
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.021	0.0572	0.1635
Echinococcus multilocularis	serotonin transporter	0.1238	0.3489	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.021	0.0572	0.1635
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0404	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Schistosoma mansoni	sodium-dependent amino acid transporter	0.021	0.0572	0.1554
Giardia lamblia	Programmed cell death protein-like protein	0.005	0.0119	1
Echinococcus multilocularis	nAChR subunit	0.0218	0.0594	0.1699
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1238	0.3489	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.0572	0.0572
Onchocerca volvulus		0.005	0.0119	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0404	0.1124	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.021	0.0572	1
Trypanosoma brucei	cytochrome P450, putative	0.003	0.006	0.0038
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.021	0.0572	0.1635
Brugia malayi	hypothetical protein	0.0187	0.0505	0.0504
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0404	0.1124	0.3218
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.021	0.0572	0.5
Loa Loa (eye worm)	hypothetical protein	0.021	0.0572	0.0572
Schistosoma mansoni	neurotransmitter gated ion channel	0.0187	0.0505	0.1361
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0404	0.1124	0.1122
Loa Loa (eye worm)	myosin regulatory light chain 1	0.005	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.021	0.0572	0.0572
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0404	0.1124	0.1122
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0187	0.0505	0.1361
Schistosoma mansoni	nAChR subunit	0.0187	0.0505	0.1361
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.021	0.0572	0.057
Schistosoma mansoni	nAChR subunit	0.0404	0.1124	0.3152
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0187	0.0505	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Echinococcus granulosus	nAChR subunit	0.0404	0.1124	0.3218
Onchocerca volvulus		0.021	0.0572	0.0515
Trichomonas vaginalis	calcium binding protein, putative	0.005	0.0119	1
Onchocerca volvulus		0.0404	0.1124	0.107
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0404	0.1124	0.1122
Loa Loa (eye worm)	LGC-31 protein	0.0404	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Echinococcus granulosus	sodium and chloride dependent glycine	0.021	0.0572	0.1635
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0187	0.0505	0.0504
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0021	0.0036	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0979	0.2754	0.7891
Mycobacterium leprae	Conserved hypothetical protein	0.0021	0.0036	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.021	0.0572	0.057
Onchocerca volvulus		0.021	0.0572	0.0515
Echinococcus granulosus	calcyphosin protein	0.005	0.0119	0.0335
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0218	0.0594	0.0593
Schistosoma mansoni	neurotransmitter gated ion channel	0.0187	0.0505	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Brugia malayi	Cation transporter family protein	0.0404	0.1124	0.1122
Schistosoma mansoni	calmodulin-related	0.005	0.0119	0.0241
Loa Loa (eye worm)	acetylcholine receptor protein	0.0187	0.0505	0.0505
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.021	0.0572	0.1554
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0979	0.2754	0.2752
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0021	0.0036	0.5
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0404	0.1124	0.1122
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.021	0.0572	0.1554
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0187	0.0505	0.0504
Trypanosoma cruzi	centrin, putative	0.005	0.0119	0.0132
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0404	0.1124	0.1124
Echinococcus granulosus	cpg binding protein	0.0032	0.0066	0.0182
Loa Loa (eye worm)	ACC-1 protein	0.0404	0.1124	0.1124
Schistosoma mansoni	myosin regulatory light chain	0.005	0.0119	0.0241
Brugia malayi	Cytochrome P450 family protein	0.003	0.006	0.0058
Trypanosoma cruzi	ferric reductase transmembrane protein, putative	0.2236	0.6323	1
Trypanosoma brucei	caltractin, putative	0.005	0.0119	0.0132
Onchocerca volvulus	Mitochondrial Rho GTPase homolog	0.005	0.0119	0.0058
Plasmodium vivax	amine transporter, putative	0.021	0.0572	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Echinococcus multilocularis	glycine receptor subunit beta	0.0404	0.1124	0.3218
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0404	0.1124	0.3218
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0404	0.1124	0.3218
Schistosoma mansoni	nAChR subunit	0.0404	0.1124	0.3152
Schistosoma mansoni	nAChR subunit	0.0187	0.0505	0.1361
Onchocerca volvulus		0.1238	0.3489	0.3449
Echinococcus multilocularis	sodium and chloride dependent glycine	0.021	0.0572	0.1635
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Trypanosoma cruzi	centrin-3	0.005	0.0119	0.0132
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.021	0.0572	0.1635
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0404	0.1124	0.3218
Schistosoma mansoni	myosin regulatory light chain	0.005	0.0119	0.0241
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0021	0.0036	0.5
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0404	0.1124	0.3218
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0404	0.1124	0.1122
Onchocerca volvulus		0.0187	0.0505	0.0447
Loa Loa (eye worm)	hypothetical protein	0.021	0.0572	0.0572
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0979	0.2754	0.7891
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0404	0.1124	0.3218
Echinococcus multilocularis	glycine receptor subunit beta	0.0404	0.1124	0.3218
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.021	0.0572	0.0572
Toxoplasma gondii	centrin family protein	0.005	0.0119	0.1548
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0404	0.1124	0.1122
Trichomonas vaginalis	caltractin, putative	0.005	0.0119	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0979	0.2754	0.7891
Loa Loa (eye worm)	hypothetical protein	0.021	0.0572	0.0572
Echinococcus multilocularis	programmed cell death protein 6	0.005	0.0119	0.0335
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0021	0.0036	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0021	0.0036	0.5
Echinococcus multilocularis	programmed cell death protein	0.005	0.0119	0.0334
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0156	0.0349
Loa Loa (eye worm)	hypothetical protein	0.005	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Echinococcus granulosus	programmed cell death protein	0.005	0.0119	0.0334
Schistosoma mansoni	cpg binding protein	0.003	0.0061	0.0073
Echinococcus granulosus	Calcium binding protein	0.005	0.0119	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Echinococcus granulosus	sodium and chloride dependent glycine	0.021	0.0572	0.1635
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0187	0.0505	0.1444
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0021	0.0036	0.5
Echinococcus granulosus	cytochrome P450 2K1	0.0021	0.0036	0.0096
Brugia malayi	Cytochrome P450 family protein	0.003	0.006	0.0058
Onchocerca volvulus	Dual oxidase homolog	0.3532	1	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.1238	0.3489	1
Toxoplasma gondii	calmodulin CAM2	0.005	0.0119	0.1548
Echinococcus granulosus	glycine receptor subunit beta	0.0404	0.1124	0.3218
Leishmania major	ferric reductase, putative	0.2236	0.6323	1
Echinococcus granulosus	programmed cell death protein 6	0.005	0.0119	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0021	0.0036	0.5
Schistosoma mansoni	myosin light chain	0.005	0.0119	0.0241
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0218	0.0594	0.0593
Leishmania major	cytochrome p450-like protein	0.003	0.006	0.0038
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0021	0.0036	0.5
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1238	0.3489	0.3489
Echinococcus multilocularis	programmed cell death protein	0.005	0.0119	0.0334
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0404	0.1124	0.1122
Echinococcus multilocularis	calcyphosin protein	0.005	0.0119	0.0335
Echinococcus multilocularis	sodium and chloride dependent glycine	0.021	0.0572	0.1635
Loa Loa (eye worm)	norepinephrine transporter	0.1238	0.3489	0.3489
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0404	0.1124	0.1122
Trypanosoma cruzi	ferric reductase transmembrane protein, putative	0.2236	0.6323	1
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Onchocerca volvulus		0.0404	0.1124	0.107
Brugia malayi	Cytochrome P450 family protein	0.0116	0.0305	0.0303
Toxoplasma gondii	hypothetical protein	0.021	0.0572	1
Entamoeba histolytica	hypothetical protein	0.0639	0.1788	1
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Onchocerca volvulus	Putative nachr subunit	0.0979	0.2754	0.2709
Trypanosoma brucei	ferric reductase transmembrane protein, putative	0.2236	0.6323	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0404	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.021	0.0572	0.0572
Brugia malayi	hypothetical protein	0.0187	0.0505	0.0504
Brugia malayi	hypothetical protein	0.021	0.0572	0.057
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0119	0.0132
Trichomonas vaginalis	caltractin, putative	0.005	0.0119	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0021	0.0036	0.5
Brugia malayi	excitatory GABA receptor EXP-1A	0.0404	0.1124	0.1122
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0021	0.0036	0.5
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.021	0.0572	0.1554
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0187	0.0505	0.0504
Loa Loa (eye worm)	GABA receptor subunit	0.0218	0.0594	0.0594
Brugia malayi	cytochrome P450	0.0021	0.0036	0.0034
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0404	0.1124	0.1122
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0404	0.1124	0.3218
Onchocerca volvulus		0.0404	0.1124	0.107
Trypanosoma brucei	centrin-3	0.005	0.0119	0.0132
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0404	0.1124	0.3218
Loa Loa (eye worm)	cytochrome P450 family protein	0.0116	0.0305	0.0305
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0404	0.1124	0.3218
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0187	0.0505	0.0504
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0404	0.1124	0.1122
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0021	0.0036	0.5
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Loa Loa (eye worm)	hypothetical protein	0.021	0.0572	0.0572
Toxoplasma gondii	hypothetical protein	0.021	0.0572	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0187	0.0505	0.1444
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0404	0.1124	0.3152
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0404	0.1124	0.3218
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0979	0.2754	0.7891
Entamoeba histolytica	grainin 2	0.005	0.0119	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Brugia malayi	CXXC zinc finger family protein	0.003	0.0061	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0021	0.0036	0.5
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.021	0.0572	0.1554
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0404	0.1124	0.3218
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.1238	0.3489	0.3489
Loa Loa (eye worm)	hypothetical protein	0.1296	0.3653	0.3653
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.021	0.0572	0.0572
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0404	0.1124	0.3152
Echinococcus multilocularis	Calcium binding protein	0.005	0.0119	0.0335
Loa Loa (eye worm)	ACC-1 protein	0.0404	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Entamoeba histolytica	calmodulin, putative	0.005	0.0119	0.0001
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0218	0.0594	0.1618
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0404	0.1124	0.3152
Schistosoma mansoni	nAChR subunit	0.0404	0.1124	0.3152
Onchocerca volvulus		0.005	0.0119	0.0058
Loa Loa (eye worm)	cytochrome P450	0.0021	0.0036	0.0036
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.021	0.0572	0.1554
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0021	0.0036	0.5
Echinococcus multilocularis	cpg binding protein	0.0032	0.0066	0.0182
Treponema pallidum	sodium- and chloride- dependent transporter	0.1238	0.3489	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0218	0.0594	0.0593
Brugia malayi	hypothetical protein	0.0187	0.0505	0.0504
Echinococcus multilocularis	nAChR subunit	0.0404	0.1124	0.3218
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1124	0.1124
Schistosoma mansoni	nAChR subunit	0.0404	0.1124	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0594	0.0594
Toxoplasma gondii	calmodulin, putative	0.005	0.0119	0.1552
Plasmodium vivax	hypothetical protein, conserved	0.021	0.0572	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.021	0.0572	0.1635

Activities

Activity type	Activity value	Assay description	Source	Reference
Delta IOP (functional)	= 0 mmHg	In vivo fall of IOP of Glaucomatous rabbits after treatment with 1 drop(50 microL) of 2% solution of CA inhibitor with pH value 5.5 into the eye at 0 min	ChEMBL.	10411484
Delta IOP (functional)	= 3.5 mmHg	In vivo fall of IOP of normotensive rabbits after treatment with 1 drop(50 microL) of 2% solution of CA inhibitor with pH value 5.5 into the eye at 30 min	ChEMBL.	10411484
Delta IOP (functional)	= 6.5 mmHg	In vivo fall of IOP of Glaucomatous rabbits after treatment with 1 drop(50 microL) of 2% solution of CA inhibitor with pH value 5.5 into the eye at 30 min	ChEMBL.	10411484
Delta IOP (functional)	= 6.8 mmHg	In vivo fall of IOP of normotensive rabbits after treatment with 1 drop(50 microL) of 2% solution of CA inhibitor with pH value 5.5 into the eye at 60 min	ChEMBL.	10411484
Delta IOP (functional)	= 9.1 mmHg	In vivo fall of IOP of normotensive rabbits after treatment with 1 drop(50 microL) of 2% solution of CA inhibitor with pH value 5.5 into the eye at 90 min.	ChEMBL.	10411484
Delta IOP (functional)	= 9.9 mmHg	In vivo fall of IOP of Glaucomatous rabbits after treatment with 1 drop(50 microL) of 2% solution of CA inhibitor with pH value 5.5 into the eye at 60 min	ChEMBL.	10411484
Delta IOP (functional)	= 12.1 mmHg	In vivo fall of IOP of Glaucomatous rabbits after treatment with 1 drop(50 microL) of 2% solution of CA inhibitor with pH value 5.5 into the eye at 90 min.	ChEMBL.	10411484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 243930

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 147027