Detailed information for compound 1520051

Basic information

Technical information
  • TDR Targets ID: 1520051
  • Name: 3-chloro-1-propan-2-yl-6,7-dihydro-5H-cyclope nta[d]pyridine-4-carbonitrile
  • MW: 220.698 | Formula: C12H13ClN2
  • H donors: 0 H acceptors: 2 LogP: 3.53 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(Cl)nc(c2c1CCC2)C(C)C
  • InChi: 1S/C12H13ClN2/c1-7(2)11-9-5-3-4-8(9)10(6-14)12(13)15-11/h7H,3-5H2,1-2H3
  • InChiKey: JIWAAPORCIUBBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-1-isopropyl-6,7-dihydro-5H-cyclopenta[d]pyridine-4-carbonitrile
  • 3-chloro-1-isopropyl-2-pyrindan-4-carbonitrile
  • ZINC00521413
  • SMR000434284
  • STOCK3S-82703
  • MLS000769552
  • 3-Chloro-1-isopropyl-6,7-dihydro-5H-[2]pyrindine-4-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0121 0.0037
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1481 0.8753
Echinococcus multilocularis protein kinase c epsilon type 0.009 0.1236 0.1236
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0121 0.0067
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0517 0.2614
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5958 0.5958
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0121 0.0037
Brugia malayi Protein kinase domain containing protein 0.0052 0.0673 0.0741
Echinococcus granulosus cathepsin l1 0.0027 0.0289 0.0289
Plasmodium vivax vivapain-1 0.0039 0.0473 0.1535
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Echinococcus granulosus Diacylglycerol kinase theta 0.0037 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0441 0.0478
Schistosoma mansoni hypothetical protein 0.0037 0.044 0.044
Plasmodium vivax vivapain-2 0.0047 0.0592 0.2042
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0121 0.0121
Giardia lamblia Hypothetical protein 0.0019 0.017 0.038
Echinococcus granulosus twitchin 0.0013 0.0071 0.0071
Echinococcus granulosus protein kinase c epsilon type 0.009 0.1236 0.1236
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0121 0.0022
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0038 0.0457 0.0457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0135
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0289 0.0289
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0101 0.1406 0.3191
Loa Loa (eye worm) AGC/PKN protein kinase 0.0052 0.0673 0.0741
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0225 0.2633
Echinococcus granulosus cysteine protease 0.0039 0.0473 0.0473
Brugia malayi cathepsin L precursor 0.0019 0.017 0.0172
Giardia lamblia Cathepsin L precursor 0.0019 0.017 0.038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0049
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0037 0.044 0.044
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.017 0.038
Loa Loa (eye worm) hypothetical protein 0.0052 0.0673 0.0741
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0517 1
Brugia malayi Cathepsin L-like precursor 0.0047 0.0592 0.0649
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0039 0.0473 0.0889
Plasmodium vivax unspecified product 0.0039 0.0473 0.1535
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0559 0.1101
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Schistosoma mansoni tyrosine kinase 0.0191 0.2767 0.2767
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0225 0.0873
Schistosoma mansoni tyrosine kinase 0.0314 0.4636 0.4636
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0172
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0038 0.0457 0.0497
Entamoeba histolytica cysteine proteinase 1, putative 0.0039 0.0473 0.3292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Brugia malayi Protein kinase domain containing protein 0.0038 0.0458 0.0498
Plasmodium falciparum heat shock protein 90 0.0045 0.0559 0.1902
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0019 0.017 0.0172
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0121 0.0117
Plasmodium vivax SET domain protein, putative 0.003 0.0331 0.093
Plasmodium falciparum glutathione reductase 0.0016 0.0121 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0473 0.3292
Giardia lamblia Cysteine protease 0.0019 0.017 0.038
Echinococcus multilocularis protein kinase c iota type 0.0596 0.8909 0.8909
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0039 0.0473 0.0473
Brugia malayi Pre-SET motif family protein 0.003 0.0331 0.0354
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0121 0.0022
Brugia malayi Cathepsin L-like precursor 0.0047 0.0592 0.0649
Schistosoma mansoni cpg binding protein 0.003 0.0329 0.0329
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Echinococcus multilocularis GPCR, family 2 0.0031 0.0343 0.0343
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0019 0.017 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0592 0.4588
Trypanosoma brucei heat shock protein 84, putative 0.003 0.033 0.1683
Echinococcus granulosus cathepsin l cysteine peptidase 0.0047 0.0592 0.0592
Loa Loa (eye worm) glutathione reductase 0.0046 0.0581 0.0636
Echinococcus granulosus protein kinase c eta type 0.0037 0.044 0.044
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Onchocerca volvulus 0.0027 0.0289 0.0368
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0052 0.0673 0.0673
Giardia lamblia Cysteine protease 0.0019 0.017 0.038
Echinococcus multilocularis protein tyrosine kinase 0.0256 0.3755 0.3755
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0559 0.423
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0473 0.3292
Trypanosoma brucei heat shock protein, putative 0.0045 0.0559 0.3451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Echinococcus granulosus neuroglian 0.0012 0.0054 0.0054
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.046 0.0858
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0163 0.0124
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.166 1
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.046 0.0858
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0592 0.4588
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0172
Schistosoma mansoni unc-13 (munc13) 0.0039 0.0469 0.0469
Echinococcus multilocularis serine:threonine protein kinase 38 0.0052 0.0673 0.0673
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0799 0.0799
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0112 0.0112
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0592 0.0592
Echinococcus multilocularis cysteine protease 0.0047 0.0592 0.0592
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.017 0.038
Onchocerca volvulus 0.0038 0.0458 0.089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0473 0.1069
Echinococcus granulosus cathepsin b 0.0283 0.4165 0.4165
Schistosoma mansoni tyrosine kinase 0.0314 0.4636 0.4636
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0073 0.0979 0.2139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.017 0.0149
Trypanosoma brucei PB1 domain containing protein, putative 0.0037 0.0441 0.254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0037 0.044 0.0478
Brugia malayi Protein kinase domain containing protein 0.0038 0.0457 0.0497
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.017 0.017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0069 0.0069
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.2531 0.2531
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.166 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0135
Schistosoma mansoni cathepsin C 0.0019 0.017 0.017
Brugia malayi cathepsin B-like cysteine proteinase 0.0283 0.4165 0.4691
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0057 0.0044
Giardia lamblia Cathepsin B precursor 0.0101 0.1406 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.044 0.294
Echinococcus multilocularis cathepsin L 0.0019 0.017 0.017
Echinococcus granulosus myotubularin protein 13 0.0037 0.044 0.044
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0343 0.0343
Brugia malayi Cathepsin L-like precursor 0.0047 0.0592 0.0649
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0517 0.3128
Echinococcus granulosus cathepsin L cysteine proteinase 0.0047 0.0592 0.0592
Echinococcus multilocularis insulin receptor 0.0191 0.2767 0.2767
Echinococcus multilocularis Protein kinase C, brain isozyme 0.009 0.1236 0.1236
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.017 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0183
Plasmodium vivax serine-repeat antigen (SERA) 0.0019 0.017 0.0245
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0121 0.0067
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0037 0.044 0.0478
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Schistosoma mansoni tyrosine kinase 0.0319 0.4716 0.4716
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0658 0.1633
Echinococcus granulosus Protein kinase C brain isozyme 0.009 0.1236 0.1236
Plasmodium falciparum serine repeat antigen 1 0.0019 0.017 0.0245
Loa Loa (eye worm) hypothetical protein 0.0283 0.4165 0.4691
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0581 0.1995
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0274 0.0686
Echinococcus granulosus protein kinase c iota type 0.0596 0.8909 0.8909
Onchocerca volvulus 0.003 0.0331 0.0496
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0019 0.017 0.0245
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0019 0.017 0.017
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0457 0.0457
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Loa Loa (eye worm) hypothetical protein 0.0047 0.0592 0.0649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Giardia lamblia Cathepsin B precursor 0.0019 0.017 0.038
Echinococcus multilocularis Diacylglycerol kinase theta 0.0037 0.044 0.044
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0319 0.4716 0.4716
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1089 1
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0592 0.0592
Schistosoma mansoni hypothetical protein 0.0401 0.5958 0.5958
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0112 0.0112
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0559 0.1101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0123 0.007
Brugia malayi diacylglycerol kinase 0.0037 0.044 0.0478
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0581 0.0581
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0283 0.4165 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.0289 0.0307
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0331 0.0331
Echinococcus multilocularis serine:threonine protein kinase N2 0.0052 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0015 0.01 0.0092
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.1406 0.1406
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.009 0.0081
Brugia malayi Cathepsin L-like precursor 0.0047 0.0592 0.0649
Brugia malayi isocitrate dehydrogenase 0.0015 0.0112 0.0107
Loa Loa (eye worm) raf kinase 0.0037 0.044 0.0478
Brugia malayi fibroinase precursor 0.0019 0.017 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.017 0.0149
Trypanosoma brucei heat shock protein, putative 0.0045 0.0559 0.3451
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0372 0.0763
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0559 0.1101
Giardia lamblia Cysteine protease 0.0019 0.017 0.038
Giardia lamblia Cathepsin B precursor 0.0101 0.1406 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0051 0.0656 0.1627
Onchocerca volvulus 0.0037 0.044 0.0834
Plasmodium falciparum heat shock protein 90, putative 0.017 0.2459 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1481 0.8844
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.018 0.0183
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0121 0.0037
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0052 0.0673 0.0741
Brugia malayi cathepsin L-like cysteine proteinase 0.0019 0.017 0.0172
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0343
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0019 0.017 0.0245
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Toxoplasma gondii cathepsin CPC1 0.0019 0.017 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0473 0.2785
Giardia lamblia Cathepsin L precursor 0.0019 0.017 0.038
Onchocerca volvulus 0.0047 0.0592 0.1302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0121 0.0022
Trypanosoma brucei heat shock protein, putative 0.0045 0.0559 0.3451
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0558 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.017 0.0149
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.166 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0101 0.1406 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.017 0.0149
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.135 0.1507
Brugia malayi protein kinase C3,putative 0.0544 0.8131 0.9178
Schistosoma mansoni nephrin 0.0012 0.0054 0.0054
Plasmodium falciparum thioredoxin reductase 0.0016 0.0121 0.0037
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0191 0.2767 0.2767
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.033 0.1742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Schistosoma mansoni protein kinase C mu 0.0037 0.044 0.044
Leishmania major cathepsin L-like protease 0.0047 0.0592 0.3706
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0673 0.0673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Loa Loa (eye worm) acetyltransferase 0.0175 0.2531 0.2843
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0191 0.2767 0.2767
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Loa Loa (eye worm) cathepsin B 0.0101 0.1406 0.157
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0038 0.0457 0.0497
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Echinococcus multilocularis epidermal growth factor receptor 0.0592 0.8858 0.8858
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0331 0.0331
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.4165 0.4165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Echinococcus granulosus cathepsin L cysteine protease 0.0039 0.0473 0.0473
Toxoplasma gondii Hsp90 domain-containing protein 0.017 0.2459 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0065 0.086 0.1845
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0123 0.007
Echinococcus granulosus geminin 0.033 0.4882 0.4882
Echinococcus granulosus GPCR family 2 0.0031 0.0343 0.0343
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0015 0.01 0.0092
Brugia malayi Hsp90 protein 0.003 0.033 0.0353
Plasmodium vivax vivapain-3 0.0039 0.0473 0.1535
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0331 0.093
Loa Loa (eye worm) ctsf protein 0.0047 0.0592 0.0649
Leishmania major heat shock protein, putative 0.003 0.033 0.1683
Loa Loa (eye worm) TK/EGFR protein kinase 0.0592 0.8858 1
Plasmodium falciparum endoplasmin, putative 0.0033 0.0372 0.1106
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.2531 0.2531
Loa Loa (eye worm) hypothetical protein 0.0027 0.0289 0.0307
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0559 0.1101
Loa Loa (eye worm) AGC/NDR protein kinase 0.0052 0.0673 0.0741
Trypanosoma cruzi cruzipain precursor, putative 0.0093 0.1282 0.2886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0558 0.0558
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0225 0.2633
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.033 0.0494
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0137 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0331 0.0331
Giardia lamblia Cathepsin L precursor 0.0019 0.017 0.038
Echinococcus multilocularis serine threonine protein kinase 0.0052 0.0673 0.0673
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.2531 0.2843
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0121 0.0022
Echinococcus granulosus epidermal growth factor receptor 0.0319 0.4716 0.4716
Schistosoma mansoni cpg binding protein 0.003 0.0329 0.0329
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.018 0.0167
Onchocerca volvulus 0.0047 0.0592 0.1302
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0121 0.0067
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0592 0.0592
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Echinococcus multilocularis Rac GTPase activating protein 1 0.0037 0.044 0.044
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.044 0.294
Echinococcus granulosus N chimaerin 0.0037 0.044 0.044
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0273 0.0289
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0558 0.061
Brugia malayi Protein kinase domain containing protein 0.0191 0.2767 0.3109
Trypanosoma cruzi cysteine peptidase, putative 0.0093 0.1282 0.2886
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0559 0.3407
Echinococcus multilocularis lamin dm0 0.0026 0.0273 0.0273
Echinococcus granulosus intermediate filament protein 0.0026 0.0273 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0019 0.017 0.0245
Entamoeba histolytica protein kinase, putative 0.0052 0.0673 0.5476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.017 0.0149
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.033 0.033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0289 0.0511
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.017 0.0149
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0112 0.0107
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1481 0.8844
Giardia lamblia Cathepsin B precursor 0.0101 0.1406 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0047 0.0592 0.2042
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0121 0.0037
Loa Loa (eye worm) zinc finger protein 0.0037 0.0441 0.0478
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0592 0.0649
Schistosoma mansoni hypothetical protein 0.033 0.4882 0.4882
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0592 0.1431
Giardia lamblia Hypothetical protein 0.0019 0.017 0.038
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0121 0.0067
Loa Loa (eye worm) hypothetical protein 0.0097 0.135 0.1507
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0225 0.0602
Schistosoma mansoni tyrosine kinase 0.0191 0.2767 0.2767
Schistosoma mansoni cpg binding protein 0.0028 0.0305 0.0305
Loa Loa (eye worm) TK/FAK protein kinase 0.0259 0.38 0.4278
Plasmodium vivax serine-repeat antigen (SERA) 0.0019 0.017 0.0245
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0019 0.017 0.017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1481 0.8844
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0019 0.017 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0581 0.3025
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0121 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Trichomonas vaginalis heat shock protein, putative 0.0038 0.046 0.1032
Schistosoma mansoni serine/threonine protein kinase 0.009 0.1236 0.1236
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0273 0.0289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0558 0.0558
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0592 0.1302
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1481 0.8844
Brugia malayi Cathepsin L-like precursor 0.0047 0.0592 0.0649
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.052 0.052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Leishmania major cysteine peptidase A (CPA) 0.0047 0.0592 0.3706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0331 0.0331
Plasmodium falciparum serine repeat antigen 6 0.0019 0.017 0.0245
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0658 0.0658
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.4165 0.4165
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Schistosoma mansoni vav2 0.0037 0.044 0.044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0331 0.0331
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0658 0.1633
Loa Loa (eye worm) hypothetical protein 0.0031 0.0343 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.009 0.1236 0.1236
Echinococcus granulosus protein tyrosine kinase 0.0256 0.3755 0.3755
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.017 0.0149
Loa Loa (eye worm) cysteine protease 0.0047 0.0592 0.0649
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0473 0.0514
Echinococcus granulosus unc 13 munc13 0.0037 0.044 0.044
Onchocerca volvulus Tyrosine kinase homolog 0.0145 0.2076 0.5884
Echinococcus granulosus defective proboscis extension response 0.0009 0.0018 0.0018
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0343 0.0368
Loa Loa (eye worm) hypothetical protein 0.0026 0.0266 0.028
Echinococcus granulosus insulin receptor 0.0191 0.2767 0.2767
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0019 0.017 0.0149
Trypanosoma brucei rac serine-threonine kinase, putative 0.0052 0.0673 0.4337
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.017 0.0149
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0559 0.1902
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.044 0.044
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Echinococcus multilocularis Immunoglobulin 0.0009 0.0018 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0225 0.0235
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0037 0.044 0.044
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0112 0.0112
Schistosoma mansoni cell polarity protein 0.0037 0.0441 0.0441
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0473 0.0889
Entamoeba histolytica protein kinase, putative 0.0052 0.0673 0.5476
Plasmodium vivax glutathione reductase, putative 0.0046 0.0581 0.1995
Trypanosoma brucei heat shock protein, putative 0.0045 0.0559 0.3451
Echinococcus multilocularis heat shock protein 90 0.0038 0.046 0.046
Echinococcus granulosus lamin dm0 0.0026 0.0273 0.0273
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0121 0.0067
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0768 0.2792
Brugia malayi p70 ribosomal S6 kinase beta 0.0052 0.0673 0.0741
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0343 0.0343
Loa Loa (eye worm) PAR-6 protein 0.0037 0.0441 0.0478
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0039 0.0473 0.2785
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.017 0.0149
Giardia lamblia Cathepsin L-like protease 0.0019 0.017 0.038
Trypanosoma brucei cysteine peptidase C (CPC) 0.0101 0.1406 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0225 0.2633
Mycobacterium tuberculosis Probable reductase 0.0106 0.1481 0.8844
Onchocerca volvulus 0.0023 0.0225 0.0171
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0026 0.0026
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0019 0.017 0.038
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0658 0.2324
Echinococcus multilocularis Immunoglobulin 0.0009 0.0018 0.0018
Brugia malayi Ras association domain family 1 isoform A 0.0037 0.044 0.0478
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Echinococcus multilocularis cathepsin L 0.0039 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Echinococcus multilocularis 0.0183 0.2648 0.2648
Plasmodium vivax heat shock protein 90, putative 0.003 0.033 0.0928
Schistosoma mansoni heat shock protein 0.003 0.033 0.033
Toxoplasma gondii cathepsin B 0.0101 0.1406 0.551
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0183
Plasmodium vivax vivapain-2 0.0047 0.0592 0.2042
Echinococcus multilocularis serine:threonine protein kinase N2 0.0052 0.0673 0.0673
Schistosoma mansoni protein kinase C mu 0.0038 0.0457 0.0457
Brugia malayi RhoGAP domain containing protein 0.0037 0.044 0.0478
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0052 0.0673 0.0741
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Entamoeba histolytica hypothetical protein 0.0037 0.044 0.294
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0121 0.0022
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0052 0.0673 0.0741
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.017 0.0149
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0037 0.044 0.044
Trypanosoma brucei heat shock protein, putative 0.0045 0.0559 0.3451
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0441 0.2948
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.017 0.0149
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0047 0.0592 0.0649
Brugia malayi glutathione reductase 0.0046 0.0581 0.0636
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Toxoplasma gondii heat shock protein 75, putative 0.003 0.033 0.0928
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0658 0.2324
Brugia malayi Pleckstrin Homology Domain 0.0037 0.044 0.0478
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0121 0.0067
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0038 0.0458 0.0498
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Echinococcus multilocularis cpg binding protein 0.003 0.0329 0.0329
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0052 0.0673 0.0673
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Brugia malayi Protein kinase domain containing protein 0.0052 0.0673 0.0741
Entamoeba histolytica protein kinase, putative 0.0052 0.0673 0.5476
Brugia malayi Immunoglobulin I-set domain containing protein 0.0155 0.2226 0.2498
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0019 0.017 0.0245
Schistosoma mansoni lamin 0.0026 0.0273 0.0273
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0473 0.3292
Brugia malayi Endoplasmin precursor 0.0045 0.0559 0.0612
Echinococcus granulosus heat shock protein 90 0.0038 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0289 0.0307
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Loa Loa (eye worm) hypothetical protein 0.0023 0.0225 0.0235
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0331 0.0331
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Brugia malayi Hr1 repeat family protein 0.0052 0.0673 0.0741
Trypanosoma cruzi cysteine protease, putative 0.0039 0.0473 0.0889
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.017 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0592 0.1431
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0057
Treponema pallidum heat shock protein 90 0.0042 0.0517 1
Echinococcus multilocularis epidermal growth factor receptor 0.0319 0.4716 0.4716
Schistosoma mansoni heat shock protein 0.0045 0.0559 0.0559
Brugia malayi protein kinase C II. 0.009 0.1236 0.1378
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0019 0.017 0.0149
Schistosoma mansoni tyrosine kinase 0.0256 0.3755 0.3755
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0135
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0273 0.0289
Echinococcus multilocularis cysteine protease 0.0047 0.0592 0.0592
Leishmania major trypanothione reductase 0.0046 0.0581 0.362
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0884 0.098
Echinococcus multilocularis protein TFG 0.0037 0.0441 0.0441
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0582 0.8694 0.9815
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.1406 0.3907
Echinococcus granulosus lamin 0.0026 0.0273 0.0273
Schistosoma mansoni heat shock protein 0.0045 0.0559 0.0559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0064 0.0064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.017 0.017
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Brugia malayi Cathepsin L-like precursor 0.002 0.018 0.0183
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0517 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0038 0.0457 0.0457
Echinococcus granulosus cpg binding protein 0.003 0.0329 0.0329
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0137 0.0411
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0172
Onchocerca volvulus 0.0037 0.044 0.0834
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0283 0.4165 0.4165
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.009 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.017 0.0149
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0343
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0343 0.0368
Mycobacterium ulcerans hypothetical protein 0.0023 0.0225 0.2633
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0593 0.2047
Echinococcus multilocularis myotubularin protein 13 0.0037 0.044 0.044
Echinococcus granulosus cathepsin L 0.0039 0.0473 0.0473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0112 0.0112
Giardia lamblia Cysteine protease 0.0019 0.017 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.017 0.0149
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.046 0.2641
Trypanosoma brucei heat shock protein, putative 0.0045 0.0559 0.3451
Trypanosoma brucei trypanothione reductase 0.0046 0.0581 0.362
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0047 0.0592 0.2042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0121 0.0037
Giardia lamblia Cathepsin B precursor 0.0019 0.017 0.038
Leishmania major hypothetical protein, conserved 0.0037 0.0441 0.254
Toxoplasma gondii thioredoxin reductase 0.0046 0.0581 0.1995
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2981 0.3352
Giardia lamblia Cathepsin B precursor 0.0019 0.017 0.038
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0112 0.0112
Brugia malayi Protein kinase c protein 2 0.0038 0.0457 0.0497
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Onchocerca volvulus 0.0047 0.0592 0.1302
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0057 0.0044
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0069 0.0069
Brugia malayi intermediate filament protein 0.0026 0.0273 0.0289
Brugia malayi cathepsin Z-like cysteine proteinase 0.0019 0.017 0.0172
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0172
Leishmania major cathepsin L-like protease 0.0093 0.1282 0.9043
Echinococcus granulosus endoplasmin 0.0042 0.0517 0.0517
Echinococcus multilocularis partitioning defective protein 6 0.0037 0.0441 0.0441
Trypanosoma brucei heat shock protein, putative 0.0045 0.0559 0.3451
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.044 0.044
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0121 0.0056
Echinococcus granulosus protein TFG 0.0037 0.0441 0.0441
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0037 0.044 0.0478
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Trypanosoma cruzi cysteine peptidase, putative 0.0093 0.1282 0.2886
Echinococcus multilocularis musashi 0.0026 0.0273 0.0273
Onchocerca volvulus 0.0037 0.0441 0.0837
Schistosoma mansoni cathepsin S (C01 family) 0.0019 0.017 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0123 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0225 0.0602
Trypanosoma cruzi cysteine proteinase, putative 0.0039 0.0473 0.0889
Schistosoma mansoni intermediate filament proteins 0.0026 0.0273 0.0273
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.052 0.052
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Leishmania major cathepsin L-like protease 0.0047 0.0592 0.3706
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0112 0.0112
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0559 0.0612
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0225 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0019 0.017 0.0149
Brugia malayi diacylglycerol kinase 0.0037 0.044 0.0478
Brugia malayi RhoGAP domain containing protein 0.0037 0.044 0.0478
Entamoeba histolytica cysteine proteinase 2 0.0039 0.0473 0.3292
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0225 0.0873
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0225 0.2633
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.052 0.052
Giardia lamblia Cathepsin B precursor 0.0019 0.017 0.038
Brugia malayi cathepsin Z-like cysteine proteinase 0.0019 0.017 0.0172
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0289 0.1296
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0172
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0121 0.0067
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0019 0.017 0.0245
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Onchocerca volvulus Cathepsin F homolog 0.0047 0.0592 0.1302
Loa Loa (eye worm) heat shock protein 75 0.003 0.033 0.0353
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0037 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0225 0.0235
Plasmodium falciparum cysteine proteinase falcipain 3 0.0047 0.0592 0.2042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0558 0.0558
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0121 0.0022
Entamoeba histolytica cysteine protease, putative 0.0047 0.0592 0.4588
Schistosoma mansoni cathepsin B (C01 family) 0.0019 0.017 0.017
Toxoplasma gondii cathepsin CPL 0.0047 0.0592 0.2042
Echinococcus multilocularis neuroglian 0.0012 0.0054 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0225 0.073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0225 0.0602
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Brugia malayi cathepsin L-like precursor 0.0027 0.0289 0.0307
Schistosoma mansoni hypothetical protein 0.033 0.4882 0.4882
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0305 0.0324
Schistosoma mansoni endoplasmin 0.0045 0.0559 0.0559
Trypanosoma cruzi cruzipain precursor, putative 0.002 0.018 0.0167
Plasmodium falciparum serine repeat antigen 4 0.0019 0.017 0.0245
Plasmodium falciparum serine repeat antigen 9 0.0019 0.017 0.0245
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0009 0.0018 0.0018
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0009 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0473 0.1069
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Onchocerca volvulus 0.0026 0.0273 0.0319
Schistosoma mansoni tyrosine kinase 0.0314 0.4636 0.4636
Trichomonas vaginalis set domain proteins, putative 0.0233 0.3408 1
Leishmania major cathepsin L-like protease 0.0093 0.1282 0.9043
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0026 0.0026
Echinococcus granulosus roundabout 2 0.0015 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0135
Schistosoma mansoni atypical protein kinase C 0.0633 0.9473 0.9473
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.017 0.0149
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0305 0.0305
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0593 0.4601
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0052 0.0673 0.0741
Trypanosoma brucei heat shock protein, putative 0.0045 0.0559 0.3451
Loa Loa (eye worm) fibroinase 0.0047 0.0592 0.0649
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.017 0.0172
Plasmodium falciparum serine repeat antigen 7 0.0019 0.017 0.0245
Giardia lamblia Cathepsin L-like protease 0.0019 0.017 0.038
Echinococcus multilocularis unc 13 (munc13) 0.0037 0.044 0.044
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0517 0.2032
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0112 0.0107
Schistosoma mansoni vesicular amine transporter 0.0009 0.0018 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0121 0.0121
Giardia lamblia Grp94/Hsp90 0.0042 0.0517 0.3081
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0225 0.2633
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.017 0.0172
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0225 0.0235
Trypanosoma cruzi PB1 domain containing protein, putative 0.0037 0.0441 0.0811
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0037 0.044 0.044
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0559 0.3451
Leishmania major cathepsin L-like protease 0.0093 0.1282 0.9043
Echinococcus granulosus cathepsin L 0.0019 0.017 0.017
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0037 0.044 0.044
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0019 0.017 0.0245
Plasmodium falciparum serine repeat antigen 5 0.0019 0.017 0.0245
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1089 1
Echinococcus granulosus NDR protein kinase 0.0052 0.0673 0.0673
Schistosoma mansoni protein kinase C 0.0037 0.044 0.044
Echinococcus multilocularis roundabout 2 0.0015 0.01 0.01
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0658 0.2324
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0112 0.0112
Trypanosoma cruzi heat shock protein, putative 0.003 0.033 0.0537
Schistosoma mansoni rac gtpase activating protein 0.0037 0.044 0.044
Brugia malayi Pre-SET motif family protein 0.0205 0.2981 0.3352
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0343
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.135 0.1507
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0581 0.0581
Loa Loa (eye worm) endoplasmin 0.0045 0.0559 0.0612
Loa Loa (eye worm) hypothetical protein 0.0037 0.044 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0558 0.0558
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0331 0.0331
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Plasmodium falciparum glutathione reductase 0.0046 0.0581 0.1995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0052 0.0673 0.0673
Plasmodium falciparum cysteine proteinase falcipain 1 0.0039 0.0473 0.1535
Trypanosoma cruzi cysteine peptidase, putative 0.0093 0.1282 0.2886
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0592 0.0649
Echinococcus multilocularis N chimaerin 0.0037 0.044 0.044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0558 0.0558
Onchocerca volvulus 0.0028 0.0305 0.0415
Schistosoma mansoni tyrosine kinase 0.0319 0.4716 0.4716
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0121 0.0037
Onchocerca volvulus 0.0047 0.0592 0.1302
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0123 0.007
Trypanosoma cruzi PB1 domain containing protein, putative 0.0037 0.0441 0.0811
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0559 0.1902
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0592 0.1302
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0274 0.0464
Brugia malayi Thioredoxin reductase 0.0046 0.0581 0.0636
Loa Loa (eye worm) hypothetical protein 0.003 0.0331 0.0354
Echinococcus multilocularis cathepsin b 0.0283 0.4165 0.4165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0121 0.0022
Brugia malayi Partitioning defective-6 homolog alpha 0.0037 0.0441 0.0478
Loa Loa (eye worm) hypothetical protein 0.0027 0.0289 0.0307
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0052 0.0673 0.0673
Brugia malayi Cathepsin L-like precursor 0.0047 0.0592 0.0649
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0559 0.3451
Schistosoma mansoni serine/threonine protein kinase 0.009 0.1236 0.1236
Toxoplasma gondii diacylglycerol kinase, putative 0.0037 0.044 0.1397
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0019 0.017 0.0245
Toxoplasma gondii cathepsin CPC2 0.0019 0.017 0.0245
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0593 0.3672
Echinococcus granulosus protein kinase C gamma type 0.0052 0.0673 0.0673
Plasmodium vivax endoplasmin, putative 0.0045 0.0559 0.1902
Entamoeba histolytica protein kinase, putative 0.0052 0.0673 0.5476
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0019 0.017 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Leishmania major cathepsin L-like protease 0.0047 0.0592 0.3706
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0558 0.061
Giardia lamblia Cathepsin L precursor 0.0019 0.017 0.038
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0559 0.3451
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0559 0.423
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.018 0.0183
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0052 0.0673 0.0673
Brugia malayi Furin-like cysteine rich region family protein 0.0592 0.8858 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0121 0.0121
Brugia malayi C1-like domain containing protein 0.0038 0.0457 0.0497
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.033 0.033
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.017 0.0172
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0137 0.0106
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0225 0.2633
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0592 0.0592
Echinococcus granulosus epidermal growth factor receptor 0.0592 0.8858 0.8858
Schistosoma mansoni cell adhesion molecule 0.0012 0.0064 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0673 0.0673
Plasmodium falciparum serine repeat antigen 2 0.0019 0.017 0.0245
Echinococcus granulosus Immunoglobulin 0.0009 0.0018 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0673 0.168
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.2456 0.2456
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Leishmania major heat shock protein 83-1 0.0045 0.0559 0.3451
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.009 0.1236 0.1378
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.017 0.017
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0559 0.1902
Schistosoma mansoni cathepsin s 0.002 0.018 0.018
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0473 0.0514
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1481 0.8844
Plasmodium vivax unspecified product 0.0019 0.017 0.0245
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0183
Schistosoma mansoni endoplasmin 0.0045 0.0559 0.0559
Schistosoma mansoni tyrosine kinase 0.0592 0.8858 0.8858
Echinococcus multilocularis heat shock protein 0.0045 0.0559 0.0559
Echinococcus multilocularis endoplasmin 0.0042 0.0517 0.0517
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.002 0.018 0.0183
Echinococcus multilocularis lamin 0.0026 0.0273 0.0273
Echinococcus multilocularis heat shock protein 90 0.0045 0.0559 0.0559
Echinococcus multilocularis protein kinase c eta type 0.0037 0.044 0.044
Brugia malayi cathepsin F-like cysteine proteinase 0.0019 0.017 0.0172
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0121 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0289 0.0511
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.046 0.046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.017 0.017
Loa Loa (eye worm) AGC/AKT protein kinase 0.0052 0.0673 0.0741
Echinococcus multilocularis cathepsin b 0.0283 0.4165 0.4165
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0019 0.017 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0473 0.3292
Onchocerca volvulus Protein TFG homolog 0.0037 0.0441 0.0837
Loa Loa (eye worm) TK/INSR protein kinase 0.0191 0.2767 0.3109
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0019 0.017 0.0149
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.017 0.0172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0592 0.0592
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0039 0.0473 0.0473
Plasmodium vivax unspecified product 0.002 0.018 0.0288
Loa Loa (eye worm) histone methyltransferase 0.001 0.0026 0.0009
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0155 0.2226 0.2498
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0592 0.1182
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0592 0.0592
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0372 0.0763
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0019 0.017 0.0245
Schistosoma mansoni tyrosine kinase 0.0011 0.0039 0.0039
Onchocerca volvulus 0.0047 0.0592 0.1302
Brugia malayi Protein kinase domain containing protein 0.0259 0.38 0.4278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Giardia lamblia Cathepsin B precursor 0.0019 0.017 0.038
Onchocerca volvulus 0.0233 0.3408 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.166 1
Plasmodium falciparum serine repeat antigen 8 0.0019 0.017 0.0245
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0137 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Plasmodium vivax heat shock protein, putative 0.017 0.2459 1
Schistosoma mansoni lamin 0.0026 0.0273 0.0273
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.008 0.1089 0.1212
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0052
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0039 0.0473 0.0473
Brugia malayi RhoGEF domain containing protein 0.0037 0.044 0.0478
Echinococcus granulosus heat shock protein 90 0.0045 0.0559 0.0559
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0343 0.0343
Onchocerca volvulus 0.0137 0.196 0.5528
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0517 0.1204
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0581 0.0636
Brugia malayi Cathepsin L-like precursor 0.0027 0.0289 0.0307
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0121 0.0022
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0581 0.1155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0517 0.1204
Brugia malayi CXXC zinc finger family protein 0.0028 0.0305 0.0324
Schistosoma mansoni serine/threonine kinase 0.0052 0.0673 0.0673
Schistosoma mansoni hypothetical protein 0.0066 0.0884 0.0884
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.017 0.017
Echinococcus granulosus cathepsin l1 0.0047 0.0592 0.0592
Trypanosoma cruzi major cysteine proteinase, putative 0.0019 0.017 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0457 0.0457
Entamoeba histolytica cysteine protease, putative 0.0039 0.0473 0.3292
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0019 0.017 0.0172
Leishmania major cathepsin L-like protease 0.0047 0.0592 0.3706
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0225 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.1282 0.9043
Onchocerca volvulus 0.0037 0.044 0.0834
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0343
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5958 0.5958
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0283 0.4165 0.4165
Echinococcus granulosus Rac GTPase activating protein 1 0.0037 0.044 0.044
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0052 0.0673 0.0673
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.135 0.1507
Plasmodium falciparum thioredoxin reductase 0.0046 0.0581 0.1995
Onchocerca volvulus 0.0026 0.0273 0.0319
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.017 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0592 0.1431
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0673 0.0673
Leishmania major cathepsin L-like protease 0.0047 0.0592 0.3706
Schistosoma mansoni unc-13 (munc13) 0.0037 0.044 0.044
Trypanosoma cruzi cysteine proteinase, putative 0.0039 0.0473 0.0889
Plasmodium falciparum serine repeat antigen 3 0.0019 0.017 0.0245
Onchocerca volvulus 0.0047 0.0592 0.1302
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0137 0.0106
Toxoplasma gondii AGC kinase 0.0052 0.0673 0.239
Echinococcus granulosus heat shock protein 0.0045 0.0559 0.0559
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0559 0.1331
Echinococcus multilocularis microtubule associated protein 2 0.0668 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0225 0.2633
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0559 0.1101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0343 0.0368
Schistosoma mansoni microtubule-associated protein tau 0.0668 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0225 0.073
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.017 0.017
Echinococcus granulosus serine:threonine protein kinase N2 0.0052 0.0673 0.0673
Loa Loa (eye worm) RasGEF domain-containing protein 0.0037 0.044 0.0478
Giardia lamblia Cathepsin L precursor 0.0019 0.017 0.038
Toxoplasma gondii preprocathepsin c precursor, putative 0.0019 0.017 0.0245
Onchocerca volvulus 0.0047 0.0592 0.1302
Brugia malayi Cathepsin L-like cysteine proteinase 0.0027 0.0289 0.0307
Brugia malayi heat shock protein 90 0.0045 0.0559 0.0612
Brugia malayi Variant SH3 domain containing protein 0.0037 0.044 0.0478
Echinococcus granulosus cathepsin b 0.0283 0.4165 0.4165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0592 0.1431
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0024 0.0007
Giardia lamblia Encystation-specific protease 0.0019 0.017 0.038
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0019 0.017 0.0245
Echinococcus multilocularis geminin 0.033 0.4882 0.4882
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0289
Brugia malayi Protein kinase domain containing protein 0.0052 0.0673 0.0741
Loa Loa (eye worm) hypothetical protein 0.0066 0.0884 0.098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0343 0.0343
Giardia lamblia Cathepsin L precursor 0.0019 0.017 0.038
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0172
Loa Loa (eye worm) hypothetical protein 0.0023 0.0225 0.0235

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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