Detailed information for compound 153008

Basic information

Technical information
  • TDR Targets ID: 153008
  • Name: 1-[4-(4-fluoro-2-methylanilino)-8-[2-(2-hydro xyethoxy)ethoxy]quinolin-3-yl]butan-1-one
  • MW: 426.481 | Formula: C24H27FN2O4
  • H donors: 2 H acceptors: 3 LogP: 4.4 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)c1cnc2c(c1Nc1ccc(cc1C)F)cccc2OCCOCCO
  • InChi: 1S/C24H27FN2O4/c1-3-5-21(29)19-15-26-24-18(6-4-7-22(24)31-13-12-30-11-10-28)23(19)27-20-9-8-17(25)14-16(20)2/h4,6-9,14-15,28H,3,5,10-13H2,1-2H3,(H,26,27)
  • InChiKey: XOMOQJRCUFEINN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(4-fluoro-2-methyl-anilino)-8-[2-(2-hydroxyethoxy)ethoxy]-3-quinolyl]butan-1-one
  • 1-[4-(4-fluoro-2-methylanilino)-8-[2-(2-hydroxyethoxy)ethoxy]-3-quinolyl]-1-butanone
  • 1-[4-[(4-fluoro-2-methyl-phenyl)amino]-8-[2-(2-hydroxyethoxy)ethoxy]quinolin-3-yl]butan-1-one
  • 1-[4-[(4-fluoro-2-methylphenyl)amino]-8-[2-(2-hydroxyethoxy)ethoxy]quinolin-3-yl]butan-1-one
  • 1-[4-[(4-fluoro-2-methyl-phenyl)amino]-8-[2-(2-hydroxyethoxy)ethoxy]-3-quinolyl]butan-1-one
  • 1-[4-[(4-fluoro-2-methylphenyl)amino]-8-[2-(2-hydroxyethoxy)ethoxy]-3-quinolyl]butan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Potassium-transporting ATPase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 24.1 %
Drosophila melanogaster nervana 1 Potassium-transporting ATPase   290 aa 305 aa 23.9 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.6 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 306 aa 26.1 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 25.6 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 254 aa 23.6 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 265 aa 22.3 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Echinococcus granulosus nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.3 %
Loa Loa (eye worm) hypothetical protein Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Potassium-transporting ATPase   290 aa 258 aa 23.6 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Potassium-transporting ATPase   290 aa 258 aa 24.4 %
Onchocerca volvulus Glutamate carboxypeptidase 2 homolog Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 21.3 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta, putative Potassium-transporting ATPase   290 aa 256 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0101 0.122 0.5796
Schistosoma mansoni hypothetical protein 0.0087 0.1011 0.1011
Echinococcus multilocularis musashi 0.0026 0.0094 0.0107
Echinococcus multilocularis copper transporting ATPase 1 0.0032 0.0181 0.0206
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi EGF-like domain containing protein 0.0087 0.1011 0.1419
Chlamydia trachomatis metal transport ATPase 0.0032 0.0181 0.5
Schistosoma mansoni septate junction protein 0.0087 0.1011 0.1011
Trichomonas vaginalis cation-transporting ATPase, putative 0.016 0.2101 1
Brugia malayi AKH receptor 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi Calcium binding EGF domain containing protein 0.0087 0.1011 0.1419
Schistosoma mansoni hypothetical protein 0.0087 0.1011 0.1011
Toxoplasma gondii P-type ATPase PMA1 0.0064 0.0668 0.3162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Echinococcus multilocularis protein jagged 2 0.0087 0.1011 0.115
Schistosoma mansoni rab6-interacting 0.0101 0.1221 0.1221
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0943 0.0943
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0101 0.122 0.5796
Trypanosoma cruzi P-type H+-ATPase, putative 0.0064 0.0668 0.3162
Schistosoma mansoni hypothetical protein 0.0087 0.1011 0.1011
Schistosoma mansoni notch 0.0087 0.1011 0.1011
Brugia malayi Na,K-ATPase alpha subunit 0.0101 0.122 0.1713
Onchocerca volvulus 0.026 0.3615 0.5076
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Onchocerca volvulus Putative cubilin 0.0087 0.1011 0.1419
Loa Loa (eye worm) hypothetical protein 0.016 0.2101 0.295
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0494 0.7122 1
Onchocerca volvulus 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Schistosoma mansoni hypothetical protein 0.0494 0.7122 0.7122
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0764 0.3033
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0494 0.7122 0.7122
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0032 0.0036
Brugia malayi E1-E2 ATPase family protein 0.0032 0.0181 0.0255
Brugia malayi RE15519p 0.0494 0.7122 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0494 0.7122 0.7122
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0005 0.0006
Echinococcus granulosus phospholipid transporting ATPase VA 0.002 0.0005 0.0006
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0069 0.0733 0.103
Schistosoma mansoni amine GPCR 0.0494 0.7122 0.7122
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0081 0.0917 0.455
Echinococcus granulosus hypothetical protein 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0132
Echinococcus granulosus nervana 2 0.0026 0.0088 0.01
Schistosoma mansoni lipoxygenase 0.0604 0.8786 0.8786
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0494 0.7122 0.8106
Schistosoma mansoni hypothetical protein 0.0101 0.1221 0.1221
Schistosoma mansoni notch 0.0087 0.1011 0.1011
Brugia malayi Serotonin receptor 0.0494 0.7122 1
Echinococcus multilocularis neural cadherin 0.0087 0.1011 0.115
Echinococcus multilocularis cation transporting ATPase 13A3 0.0032 0.0181 0.0206
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0081 0.0917 0.7082
Schistosoma mansoni histamine h1 receptor 0.0494 0.7122 0.7122
Echinococcus granulosus cation transporting ATPase 13A3 0.0032 0.0181 0.0206
Echinococcus multilocularis allatostatin A receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Onchocerca volvulus 0.0494 0.7122 1
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0044 0.0365 0.1716
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0101 0.122 0.5411
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0032 0.0181 0.0206
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) G-protein coupled receptor 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Loa Loa (eye worm) calcium ATPase 0.0057 0.0557 0.0783
Onchocerca volvulus 0.0494 0.7122 1
Onchocerca volvulus 0.0494 0.7122 1
Brugia malayi Calcium binding EGF domain containing protein 0.0087 0.1011 0.1419
Schistosoma mansoni neuropeptide f receptor 76f 0.0494 0.7122 0.7122
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.026 0.3615 0.5076
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0494 0.7122 1
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0032 0.0181 0.0206
Echinococcus granulosus g protein coupled receptor 0.0494 0.7122 0.8106
Trypanosoma cruzi P-type H+-ATPase, putative 0.0064 0.0668 0.3162
Brugia malayi EGF-like domain containing protein 0.0087 0.1011 0.1419
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0088 0.0088
Echinococcus multilocularis calcium transporting atpase 0.0139 0.1798 0.2046
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Echinococcus granulosus g-protein coupled receptor 0.0494 0.7122 0.8106
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0032 0.0032
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0101 0.122 0.5411
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0266
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0044 0.0365 0.0513
Loa Loa (eye worm) melatonin receptor type 1A 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.026 0.3615 0.5076
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0088 0.01
Echinococcus granulosus neurogenic locus notch protein 0.0087 0.1011 0.115
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Schistosoma mansoni lamin 0.0026 0.0094 0.0094
Brugia malayi MAP kinase sur-1 0.0049 0.0443 0.0621
Echinococcus granulosus neurogenic locus notch protein 4 0.0087 0.1011 0.115
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Onchocerca volvulus 0.0494 0.7122 1
Schistosoma mansoni opsin-like receptor 0.0494 0.7122 0.7122
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0443 0.1615
Schistosoma mansoni ATPase 0.016 0.2101 0.2101
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0076 0.0838 0.0954
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0494 0.7122 0.8106
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0087 0.1011 0.1419
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) animal heme peroxidase 0.0269 0.3752 0.5268
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Schistosoma mansoni neuropeptide F-like receptor 0.0494 0.7122 0.7122
Brugia malayi Peroxidasin 0.0269 0.3752 0.5268
Echinococcus granulosus serotonin receptor 0.0494 0.7122 0.8106
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0032 0.0032
Echinococcus granulosus fibropellin Ia 0.0087 0.1011 0.115
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus granulosus neuropeptides capa receptor 0.0494 0.7122 0.8106
Brugia malayi Animal haem peroxidase family protein 0.0269 0.3752 0.5268
Echinococcus multilocularis g protein coupled receptor 0.0494 0.7122 0.8106
Plasmodium falciparum LCCL domain-containing protein 0.0101 0.1221 0.5416
Brugia malayi notch-like transmembrane receptor 0.0087 0.1011 0.1419
Echinococcus granulosus protein jagged 2 0.0087 0.1011 0.115
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0443 0.136
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus granulosus calcium transporting ATPase type 2C member 0.016 0.2101 0.2391
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0026 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.122 0.1713
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Schistosoma mansoni neuropeptide receptor 0.0494 0.7122 0.7122
Echinococcus granulosus 7tm_1 domain containing protein 0.0494 0.7122 0.8106
Echinococcus granulosus allatostatin A receptor 0.0494 0.7122 0.8106
Echinococcus multilocularis fat cadherin tumor suppressor 0.0087 0.1011 0.115
Brugia malayi Membrane calcium atpase protein 3 0.0081 0.0917 0.1287
Brugia malayi EGF-like domain containing protein 0.0087 0.1011 0.1419
Onchocerca volvulus Slit protein homolog 0.0087 0.1011 0.1419
Brugia malayi hypothetical protein 0.0269 0.3752 0.5268
Echinococcus multilocularis neurogenic locus notch protein 0.0087 0.1011 0.115
Echinococcus multilocularis neuropeptide receptor A26 0.0494 0.7122 0.8106
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0494 0.7122 0.7122
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Onchocerca volvulus 0.0494 0.7122 1
Schistosoma mansoni opsin-like receptor 0.0494 0.7122 0.7122
Echinococcus granulosus tm gpcr rhodopsin 0.0494 0.7122 0.8106
Schistosoma mansoni hypothetical protein 0.0349 0.495 0.495
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0107 0.1311 0.1841
Echinococcus granulosus neuropeptide receptor 0.0494 0.7122 0.8106
Trypanosoma brucei P-type H+-ATPase, putative 0.0064 0.0668 0.3011
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0076 0.0838 0.1177
Echinococcus granulosus translocator protein 0.026 0.3615 0.4115
Loa Loa (eye worm) neuropeptide F receptor 0.0494 0.7122 1
Echinococcus multilocularis serotonin receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi TspO/MBR family protein 0.026 0.3615 0.5076
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0044 0.0365 0.1716
Echinococcus multilocularis translocator protein 0.026 0.3615 0.4115
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0005 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0494 0.7122 0.8106
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0059 0.0583 0.7285
Onchocerca volvulus 0.0494 0.7122 1
Brugia malayi Animal haem peroxidase family protein 0.0269 0.3752 0.5268
Trypanosoma cruzi P-type H+-ATPase, putative 0.0044 0.0365 0.1716
Echinococcus granulosus neurogenic locus protein delta 0.0087 0.1011 0.115
Echinococcus granulosus sex peptide receptor 0.0494 0.7122 0.8106
Brugia malayi Doublecortin family protein 0.0101 0.1221 0.1714
Brugia malayi Tachykinin-like peptides receptor 99D 0.0494 0.7122 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0066 0.0688 0.0966
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0088 0.01
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0494 0.7122 0.8106
Echinococcus granulosus lipoxygenase domain containing protein 0.0101 0.1221 0.139
Brugia malayi EGF-like domain containing protein 0.0087 0.1011 0.1419
Echinococcus multilocularis neuropeptide Y receptor 0.0494 0.7122 0.8106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0122
Brugia malayi hypothetical protein 0.0494 0.7122 1
Brugia malayi Calcium binding EGF domain containing protein 0.0087 0.1011 0.1419
Onchocerca volvulus 0.0494 0.7122 1
Echinococcus multilocularis lamin dm0 0.0026 0.0094 0.0107
Brugia malayi G-protein coupled receptor 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi follicle stimulating hormone receptor 0.0494 0.7122 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0081 0.0917 0.435
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0139 0.1798 0.1798
Giardia lamblia High cysteine protein 0.0087 0.1011 0.7986
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0764 0.3033
Brugia malayi hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0101 0.122 0.5411
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0494 0.7122 0.8106
Echinococcus multilocularis serotonin receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) blistered cuticle protein 3 0.0269 0.3752 0.5268
Schistosoma mansoni opsin-like receptor 0.0494 0.7122 0.7122
Brugia malayi GnHR receptor homolog 0.0494 0.7122 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0081 0.0917 0.3832
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Onchocerca volvulus 0.0494 0.7122 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0101 0.122 0.1388
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0081 0.0917 0.1044
Echinococcus multilocularis g protein coupled receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0494 0.7122 0.7122
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0443 0.136
Echinococcus granulosus alpha 1A adrenergic receptor 0.0494 0.7122 0.8106
Schistosoma mansoni hypothetical protein 0.0087 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Echinococcus granulosus delta-like protein 1 0.0087 0.1011 0.115
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.016 0.2101 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0088 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0427 0.0599
Echinococcus granulosus peptide allatostatin:somatostatin 0.0494 0.7122 0.8106
Echinococcus multilocularis phospholipid transporting ATPase VA 0.002 0.0005 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0101 0.122 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0494 0.7122 0.8106
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0101 0.122 1
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0943 0.0943
Brugia malayi intermediate filament protein 0.0026 0.0094 0.0132
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0101 0.122 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0101 0.122 0.5411
Onchocerca volvulus 0.0026 0.0094 0.0132
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0081 0.0917 0.7082
Onchocerca volvulus 0.0101 0.1221 0.1714
Echinococcus granulosus Na:K ATPase alpha subunit 0.0081 0.0917 0.1044
Echinococcus granulosus neural cadherin 0.0087 0.1011 0.115
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0101 0.122 1
Schistosoma mansoni neuropeptide F-like receptor 0.0494 0.7122 0.7122
Schistosoma mansoni hypothetical protein 0.0087 0.1011 0.1011
Echinococcus granulosus tm gpcr rhodopsin 0.0494 0.7122 0.8106
Echinococcus granulosus geminin 0.0349 0.495 0.5634
Echinococcus multilocularis Polycystic kidney disease protein 0.0101 0.1221 0.139
Brugia malayi hypothetical protein 0.0494 0.7122 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0101 0.1221 0.139
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0494 0.7122 0.8106
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0081 0.0917 0.0917
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0032 0.0181 0.084
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0443 0.0504
Schistosoma mansoni neuropeptide receptor 0.0494 0.7122 0.7122
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0494 0.7122 0.8106
Onchocerca volvulus 0.0087 0.1011 0.1419
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.0255
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0494 0.7122 1
Echinococcus granulosus neuropeptide Y receptor 0.0494 0.7122 0.8106
Echinococcus multilocularis neurogenic locus protein delta 0.0087 0.1011 0.115
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus multilocularis geminin 0.0349 0.495 0.5634
Echinococcus multilocularis nervana 2 0.0026 0.0088 0.01
Loa Loa (eye worm) Notch2 0.0087 0.1011 0.1419
Onchocerca volvulus 0.026 0.3615 0.5076
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0032 0.0036
Brugia malayi EGF-like domain containing protein 0.0087 0.1011 0.1419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.016 0.2101 0.2391
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0081 0.0917 0.0917
Schistosoma mansoni polycystin 1-related 0.0101 0.1221 0.1221
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0403 0.0459
Echinococcus multilocularis neuropeptide receptor 0.0494 0.7122 0.8106
Schistosoma mansoni cation-transporting ATPase 0.0032 0.0181 0.0181
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0494 0.7122 0.8106
Echinococcus multilocularis neurogenic locus protein delta 0.0087 0.1011 0.115
Leishmania major calcium motive p-type ATPase, putative 0.0081 0.0917 0.3832
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0427 0.0599
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0494 0.7122 0.7122
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0032 0.0181 0.084
Echinococcus granulosus neurogenic locus notch protein 0.0087 0.1011 0.115
Schistosoma mansoni hypothetical protein 0.0494 0.7122 0.7122
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0139 0.1798 0.1798
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0494 0.7122 0.8106
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0032 0.0181 0.084
Brugia malayi hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0494 0.7122 1
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0443 0.2514
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0032 0.0181 0.0255
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0101 0.122 0.5411
Plasmodium falciparum calcium-transporting ATPase 0.0139 0.1798 0.8421
Echinococcus granulosus neuropeptide s receptor 0.0494 0.7122 0.8106
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0443 0.0504
Echinococcus multilocularis peroxidasin 0.0269 0.3752 0.427
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0044 0.0365 0.0513
Schistosoma mansoni hypothetical protein 0.0349 0.495 0.495
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0044 0.0365 0.1769
Schistosoma mansoni slit 0.0087 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0057 0.0557 0.362
Schistosoma mansoni peroxidasin 0.0269 0.3752 0.3752
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0494 0.7122 1
Schistosoma mansoni atpase class VI type 11c 0.002 0.0005 0.0005
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0494 0.7122 0.8106
Trypanosoma brucei calcium-transporting ATPase, putative 0.0048 0.043 0.1539
Echinococcus granulosus neuropeptides capa receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0494 0.7122 1
Brugia malayi Cadherin domain containing protein 0.0087 0.1011 0.1419
Schistosoma mansoni laminin gamma-3 chain 0.0087 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Schistosoma mansoni amine GPCR 0.0494 0.7122 0.7122
Brugia malayi larval opioid receptor 0.0494 0.7122 1
Brugia malayi calcium ATPase 0.0037 0.0254 0.0357
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0494 0.7122 0.7122
Leishmania major P-type ATPase, putative 0.0081 0.0917 0.3832
Echinococcus multilocularis neuropeptide Y receptor 0.0494 0.7122 0.8106
Onchocerca volvulus 0.0494 0.7122 1
Schistosoma mansoni hypothetical protein 0.0033 0.0197 0.0197
Onchocerca volvulus Peroxidase homolog 0.0269 0.3752 0.5268
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0443 0.2086
Schistosoma mansoni myosin xvIII 0.0494 0.7122 0.7122
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Onchocerca volvulus 0.0494 0.7122 1
Brugia malayi putative neuropeptide receptor 0.0494 0.7122 1
Schistosoma mansoni cell polarity protein 0.0087 0.1011 0.1011
Brugia malayi hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0365 0.0513
Schistosoma mansoni type V p-type atpase isoform 0.0032 0.0181 0.0181
Onchocerca volvulus Neuropeptide F receptor homolog 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Schistosoma mansoni biogenic amine (5HT) receptor 0.0494 0.7122 0.7122
Echinococcus multilocularis RUN 0.0101 0.1221 0.139
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.2086 0.2086
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0403 0.1156
Loa Loa (eye worm) animal heme peroxidase 0.0269 0.3752 0.5268
Onchocerca volvulus 0.0494 0.7122 1
Brugia malayi ORL1-like opioid receptor 0.0494 0.7122 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0604 0.8786 1
Echinococcus multilocularis cation transporting atpase worm 0.0032 0.0181 0.0206
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Trypanosoma brucei calcium-translocating P-type ATPase 0.0139 0.1798 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Echinococcus granulosus g protein coupled receptor 0.0494 0.7122 0.8106
Brugia malayi Delta serrate ligand family protein 0.0087 0.1011 0.1419
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0069 0.0733 0.1607
Echinococcus multilocularis protein jagged 1 0.0087 0.1011 0.115
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0124
Echinococcus multilocularis fmrfamide receptor 0.0494 0.7122 0.8106
Schistosoma mansoni lipoxygenase 0.0422 0.6053 0.6053
Brugia malayi putative neuropeptide receptor NPR1 0.0494 0.7122 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0494 0.7122 0.8106
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0494 0.7122 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0081 0.0917 0.435
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Brugia malayi Animal haem peroxidase family protein 0.0269 0.3752 0.5268
Echinococcus granulosus nervana 2 0.0026 0.0088 0.01
Treponema pallidum cation-transporting ATPase, P-type 0.0032 0.0181 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Brugia malayi hypothetical protein 0.0101 0.1221 0.1714
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0494 0.7122 0.7122
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Echinococcus multilocularis nervana 2 0.0026 0.0088 0.01
Leishmania major P-type H -ATPase, putative 0.0064 0.0668 0.2536
Loa Loa (eye worm) hypothetical protein 0.0091 0.107 0.1502
Brugia malayi calcium ATPase 0.0044 0.0365 0.0513
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0081 0.0917 0.435
Onchocerca volvulus 0.0087 0.1011 0.1419
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus granulosus copper transporting ATPase 1 0.0032 0.0181 0.0206
Onchocerca volvulus 0.0494 0.7122 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0081 0.0917 0.0917
Onchocerca volvulus 0.0087 0.1011 0.1419
Leishmania major calcium-transporting ATPase, putative 0.0081 0.0917 0.3832
Echinococcus granulosus peroxidasin 0.0269 0.3752 0.427
Echinococcus granulosus nervana 2 0.0026 0.0088 0.01
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0107 0.1311 0.1841
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0101 0.122 0.5411
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0069 0.0733 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0494 0.7122 0.8106
Schistosoma mansoni adenoreceptor 0.0494 0.7122 0.7122
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0005 0.0006
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0494 0.7122 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Schistosoma mansoni transmemberane protein 0.0026 0.0088 0.0088
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0081 0.0917 0.1044
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0026 0.0088 0.01
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0101 0.122 0.6425
Echinococcus granulosus g protein coupled receptor 0.0494 0.7122 0.8106
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0076 0.0838 0.1177
Echinococcus multilocularis sex peptide receptor 0.0494 0.7122 0.8106
Echinococcus multilocularis slit 2 protein 0.0087 0.1011 0.115
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Onchocerca volvulus Neurogenic locus notch homolog 0.0087 0.1011 0.1419
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0494 0.7122 1
Onchocerca volvulus 0.0269 0.3752 0.5268
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0139 0.1798 0.1798
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0443 0.136
Schistosoma mansoni hypothetical protein 0.0494 0.7122 0.7122
Echinococcus granulosus protein jagged 2 0.0087 0.1011 0.115
Brugia malayi G-protein coupled receptor 0.0494 0.7122 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0443 0.136
Loa Loa (eye worm) doublecortin family protein 0.0101 0.1221 0.1714
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0044 0.0365 0.1716
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Brugia malayi neuropeptide F receptor 0.0494 0.7122 1
Schistosoma mansoni notch 0.0087 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Schistosoma mansoni amine GPCR 0.0494 0.7122 0.7122
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0057 0.0557 0.362
Trypanosoma brucei protein kinase, putative 0.0049 0.0443 0.1615
Loa Loa (eye worm) hypothetical protein 0.0101 0.1221 0.1714
Echinococcus multilocularis orexin receptor type 2 0.0494 0.7122 0.8106
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0101 0.122 0.1388
Loa Loa (eye worm) E1-E2 ATPase 0.0064 0.0668 0.0938
Schistosoma mansoni lamin 0.0026 0.0094 0.0094
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0101 0.122 0.1713
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0443 0.136
Echinococcus multilocularis neuropeptide receptor 0.0494 0.7122 0.8106
Brugia malayi Cadherin domain containing protein 0.0087 0.1011 0.1419
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0443 0.2086
Loa Loa (eye worm) notch protein 0.0087 0.1011 0.1419
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0443 0.2086
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0494 0.7122 1
Onchocerca volvulus 0.026 0.3615 0.5076
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Echinococcus granulosus neuropeptide FF receptor 2 0.0494 0.7122 0.8106
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0087 0.1011 0.1419
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0081 0.0917 0.1044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0494 0.7122 0.7122
Brugia malayi G protein-coupled receptor F59B2.13 0.0494 0.7122 1
Brugia malayi Animal haem peroxidase family protein 0.0269 0.3752 0.5268
Echinococcus granulosus neuropeptide receptor A26 0.0494 0.7122 0.8106
Echinococcus multilocularis G protein coupled receptor 139 0.0494 0.7122 0.8106
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0494 0.7122 0.7122
Echinococcus multilocularis g-protein coupled receptor 0.0494 0.7122 0.8106
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Echinococcus granulosus nervana 2 0.0026 0.0088 0.01
Schistosoma mansoni loxhd1 0.0101 0.1221 0.1221
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.0255
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0494 0.7122 0.8106
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0032 0.0181 0.0255
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0494 0.7122 0.7122
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0032 0.0036
Schistosoma mansoni biogenic amine receptor 0.0494 0.7122 0.7122
Schistosoma mansoni cation-transporting atpase worm 0.0032 0.0181 0.0181
Trypanosoma cruzi Calcium ATPase SERCA-like 0.016 0.2101 1
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0005 0.0006
Brugia malayi Melatonin receptor type 1A 0.0494 0.7122 1
Echinococcus multilocularis neuropeptide s receptor 0.0494 0.7122 0.8106
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0403 0.1156
Brugia malayi EGF-like domain containing protein 0.0087 0.1011 0.1419
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0311 0.4382 0.6152
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0494 0.7122 0.7122
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0443 0.0504
Echinococcus granulosus histone acetyltransferase KAT2B 0.0154 0.2019 0.2298
Loa Loa (eye worm) hypothetical protein 0.0033 0.0197 0.0277
Echinococcus granulosus intermediate filament protein 0.0026 0.0094 0.0107
Onchocerca volvulus Dual oxidase homolog 0.0269 0.3752 0.5268
Echinococcus multilocularis nervana 2 0.0026 0.0088 0.01
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0494 0.7122 0.8106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Echinococcus granulosus dro:myosuppressin receptor 0.0494 0.7122 0.8106
Echinococcus multilocularis protein jagged 1 0.0087 0.1011 0.115
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Onchocerca volvulus 0.0494 0.7122 1
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0032 0.0181 0.084
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0443 0.0504
Brugia malayi Muscle positioning protein 4 0.0087 0.1011 0.1419
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0101 0.1221 0.139
Echinococcus multilocularis neuropeptides capa receptor 0.0494 0.7122 0.8106
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0048 0.043 0.2027
Brugia malayi hypothetical protein 0.0494 0.7122 1
Plasmodium vivax calcium-transporting ATPase, putative 0.016 0.2101 1
Loa Loa (eye worm) hypothetical protein 0.026 0.3615 0.5076
Echinococcus granulosus Polycystic kidney disease protein 0.0101 0.1221 0.139
Trichomonas vaginalis cation-transporting ATPase, putative 0.0064 0.0668 0.2536
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0088 0.0088
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0494 0.7122 0.8106
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0081 0.0917 0.1044
Onchocerca volvulus 0.0311 0.4382 0.6152
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Loa Loa (eye worm) animal heme peroxidase 0.0269 0.3752 0.5268
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0069 0.0733 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0494 0.7122 0.8106
Trypanosoma brucei P-type H+-ATPase, putative 0.0064 0.0668 0.3011
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0604 0.8786 1
Schistosoma mansoni phosphoserine phosphatase 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Mycobacterium ulcerans tryptophan-rich sensory protein 0.026 0.3615 1
Onchocerca volvulus Peroxidasin homolog 0.0269 0.3752 0.5268
Schistosoma mansoni notch 0.0087 0.1011 0.1011
Echinococcus granulosus 7TM GPCR rhodopsin 0.0494 0.7122 0.8106
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.026 0.3615 0.3615
Loa Loa (eye worm) hypothetical protein 0.0101 0.1221 0.1714
Leishmania major calcium-translocating P-type ATPase 0.016 0.2101 1
Brugia malayi Animal haem peroxidase family protein 0.0269 0.3752 0.5268
Loa Loa (eye worm) hypothetical protein 0.026 0.3615 0.5076
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0101 0.122 0.5411
Schistosoma mansoni cation-transporting atpase worm 0.0032 0.0181 0.0181
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0032 0.0044
Brugia malayi Dopamine receptor protein 1 0.0494 0.7122 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0494 0.7122 0.8106
Toxoplasma gondii EGF family domain-containing protein 0.0087 0.1011 0.4798
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.016 0.2101 1
Schistosoma mansoni hypothetical protein 0.0087 0.1011 0.1011
Brugia malayi Serotonin receptor 0.0494 0.7122 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0087 0.1011 0.115
Toxoplasma gondii P-type ATPase4, putative 0.0101 0.122 0.5796
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0088 0.01
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0087 0.1011 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Schistosoma mansoni notch 0.0087 0.1011 0.1011
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0026 0.0088 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0427 0.0599
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0494 0.7122 0.7122
Echinococcus multilocularis phosphoserine phosphatase 0.002 0.0005 0.0006
Brugia malayi Blistered cuticle protein 3 0.0269 0.3752 0.5268
Schistosoma mansoni growth hormone secretagogue receptor 0.0494 0.7122 0.7122
Echinococcus granulosus protein jagged 1 0.0087 0.1011 0.115
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.016 0.2101 0.2391
Schistosoma mansoni peroxidasin 0.0269 0.3752 0.3752
Echinococcus granulosus tachykinin peptides receptor 99D 0.0494 0.7122 0.8106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0494 0.7122 0.7122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Echinococcus multilocularis fibropellin Ia 0.0087 0.1011 0.115
Brugia malayi hypothetical protein 0.0494 0.7122 1
Schistosoma mansoni notch 0.0087 0.1011 0.1011
Brugia malayi G protein-coupled receptor 0.0494 0.7122 1
Echinococcus multilocularis lamin 0.0026 0.0094 0.0107
Echinococcus granulosus G protein coupled receptor 139 0.0494 0.7122 0.8106
Onchocerca volvulus 0.0101 0.122 0.1713
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Echinococcus granulosus slit 2 protein 0.0087 0.1011 0.115
Onchocerca volvulus 0.0026 0.0088 0.0124
Schistosoma mansoni copper ABC transporter ATPase 0.0032 0.0181 0.0181
Onchocerca volvulus 0.0087 0.1011 0.1419
Onchocerca volvulus 0.0494 0.7122 1
Onchocerca volvulus 0.0087 0.1011 0.1419
Loa Loa (eye worm) neuropeptide F receptor 0.0494 0.7122 1
Onchocerca volvulus 0.0026 0.0094 0.0132
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0057 0.0557 0.0783
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0197 0.0277
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.0255
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Schistosoma mansoni ATPase 0.016 0.2101 0.2101
Echinococcus multilocularis neurogenic locus notch protein 0.0087 0.1011 0.115
Echinococcus granulosus protein jagged 1 0.0087 0.1011 0.115
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus multilocularis notch 0.0087 0.1011 0.115
Schistosoma mansoni biogenic amine receptor 0.0494 0.7122 0.7122
Echinococcus granulosus RUN 0.0101 0.1221 0.139
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Onchocerca volvulus Chorion peroxidase homolog 0.0269 0.3752 0.5268
Onchocerca volvulus 0.0269 0.3752 0.5268
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Echinococcus multilocularis neuropeptide FF receptor 2 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi neuropeptide F receptor 0.0494 0.7122 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0345 0.0852
Brugia malayi Dopamine receptor protein 2 0.0494 0.7122 1
Onchocerca volvulus 0.0494 0.7122 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0494 0.7122 0.7122
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0403 0.1898
Echinococcus multilocularis neuropeptides capa receptor 0.0494 0.7122 0.8106
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0101 0.122 0.5796
Brugia malayi hypothetical protein 0.0101 0.1221 0.1714
Brugia malayi hypothetical protein 0.0494 0.7122 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0494 0.7122 1
Plasmodium vivax P-type ATPase4, putative 0.016 0.2101 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0101 0.1221 0.5416
Echinococcus granulosus calcium transporting atpase 0.0139 0.1798 0.2046
Echinococcus granulosus lamin dm0 0.0026 0.0094 0.0107
Loa Loa (eye worm) hypothetical protein 0.0037 0.0254 0.0357
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus granulosus fmrfamide receptor 0.0494 0.7122 0.8106
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.2086 0.2928
Onchocerca volvulus 0.0494 0.7122 1
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0494 0.7122 0.8106
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0101 0.122 1
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Echinococcus granulosus neuropeptide receptor 0.0494 0.7122 0.8106
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0443 0.136
Onchocerca volvulus 0.0101 0.1221 0.1714
Schistosoma mansoni hypothetical protein 0.0087 0.1011 0.1011
Echinococcus granulosus cation transporting atpase worm 0.0032 0.0181 0.0206
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0494 0.7122 0.7122
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus granulosus notch 0.0087 0.1011 0.115
Echinococcus granulosus neuropeptide Y receptor 0.0494 0.7122 0.8106
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0494 0.7122 0.8106
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0345 0.1574
Trichomonas vaginalis cation-transporting ATPase, putative 0.016 0.2101 1
Brugia malayi E1-E2 ATPase family protein 0.0064 0.0668 0.0938
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0403 0.1156
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0101 0.122 0.5411
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0427 0.0599
Loa Loa (eye worm) animal heme peroxidase 0.0269 0.3752 0.5268
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0101 0.122 0.6425
Onchocerca volvulus Peroxidasin homolog 0.0269 0.3752 0.5268
Loa Loa (eye worm) G-protein coupled receptor 0.0494 0.7122 1
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0139 0.1798 0.2524
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0345 0.1574
Loa Loa (eye worm) hypothetical protein 0.0048 0.043 0.0604
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0032 0.0181 0.0181
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0494 0.7122 0.8106
Schistosoma mansoni amine GPCR 0.0494 0.7122 0.7122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0494 0.7122 0.7122
Echinococcus multilocularis somatostatin receptor 0.0494 0.7122 0.8106
Schistosoma mansoni intermediate filament proteins 0.0026 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0269 0.3752 0.5268
Trypanosoma cruzi cation-transporting ATPase, putative 0.0032 0.0181 0.084
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0101 0.122 0.6425
Loa Loa (eye worm) TYRA-2 protein 0.0494 0.7122 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Brugia malayi GCC2 and GCC3 family protein 0.0087 0.1011 0.1419
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0095 0.1135 0.5392
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0088 0.01
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0443 0.2086
Echinococcus granulosus rhodopsin orphan GPCR 0.0494 0.7122 0.8106
Onchocerca volvulus Peroxidase homolog 0.0269 0.3752 0.5268
Echinococcus granulosus tm gpcr rhodopsin 0.0494 0.7122 0.8106
Brugia malayi Dopamine receptor 0.0494 0.7122 1
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0081 0.0917 0.1044
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0094 0.0132
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0403 0.1898
Leishmania major P-type H -ATPase, putative 0.0064 0.0668 0.2536
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Onchocerca volvulus 0.0269 0.3752 0.5268
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0094 0.0132
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.016 0.2101 0.2391
Echinococcus granulosus somatostatin receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0069 0.0733 0.103
Onchocerca volvulus 0.0026 0.0088 0.0124
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0101 0.122 0.122
Schistosoma mansoni biogenic amine receptor 0.0494 0.7122 0.7122
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0124
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi hypothetical protein 0.0311 0.4382 0.6152
Echinococcus multilocularis nervana 2 0.0026 0.0088 0.01
Echinococcus granulosus biogenic amine 5HT receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) acetyltransferase 0.0159 0.2086 0.2928
Onchocerca volvulus 0.026 0.3615 0.5076
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0443 0.2086
Schistosoma mansoni hypothetical protein 0.0494 0.7122 0.7122
Echinococcus multilocularis lipoxygenase domain containing protein 0.0101 0.1221 0.139
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0101 0.122 0.3024
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Schistosoma mansoni neuropeptide receptor 0.0494 0.7122 0.7122
Brugia malayi EGF-like domain containing protein 0.0087 0.1011 0.1419
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0094 0.0132
Brugia malayi sulfakinin receptor protein 0.0494 0.7122 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.2086 0.2374
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Echinococcus granulosus lamin 0.0026 0.0094 0.0107
Echinococcus multilocularis fmrfamide receptor 0.0494 0.7122 0.8106
Loa Loa (eye worm) hypothetical protein 0.0494 0.7122 1
Brugia malayi hypothetical protein 0.0105 0.1282 0.18
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0088 0.01
Loa Loa (eye worm) hypothetical protein 0.0087 0.1011 0.1419
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0443 0.0621
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.016 0.2101 0.559
Schistosoma mansoni amine GPCR 0.0494 0.7122 0.7122
Echinococcus multilocularis cation transporting ATPase 13A1 0.0032 0.0181 0.0206
Schistosoma mansoni neuropeptide receptor 0.0494 0.7122 0.7122
Brugia malayi hypothetical protein 0.0494 0.7122 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0101 0.122 0.5411
Echinococcus granulosus orexin receptor type 2 0.0494 0.7122 0.8106
Schistosoma mansoni rab6-interacting 0.0101 0.1221 0.1221
Echinococcus granulosus cation transporting ATPase 13A1 0.0032 0.0181 0.0206
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0076 0.0838 0.0954
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0443 0.0443

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 uM Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7 ChEMBL. 7629813
IC50 (binding) = 4 uM Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7 ChEMBL. 7629813
Inhibition (functional) = 49 % Inhibition of pentagastrin-stimulated gastric acid secretion at a single dose of 10 micromol/kg. ChEMBL. 7629813
Inhibition (functional) = 49 % Inhibition of pentagastrin-stimulated gastric acid secretion at a single dose of 10 micromol/kg. ChEMBL. 7629813

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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