Detailed information for compound 1542632

Basic information

Technical information
  • TDR Targets ID: 1542632
  • Name: ethyl 1-ethyl-3-furan-2-yl-5-methyl-4,6-dioxo -2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1- carboxylate
  • MW: 320.34 | Formula: C16H20N2O5
  • H donors: 1 H acceptors: 3 LogP: 0.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1(CC)NC(C2C1C(=O)N(C2=O)C)c1ccco1
  • InChi: 1S/C16H20N2O5/c1-4-16(15(21)22-5-2)11-10(13(19)18(3)14(11)20)12(17-16)9-7-6-8-23-9/h6-8,10-12,17H,4-5H2,1-3H3
  • InChiKey: FNQXFFKVMKUUJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 1-ethyl-3-(2-furyl)-5-methyl-4,6-dioxo-2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1-carboxylate
  • 1-ethyl-3-(2-furyl)-5-methyl-4,6-dioxo-2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester
  • 1-ethyl-3-(2-furyl)-4,6-diketo-5-methyl-2,3,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester
  • 1-Ethyl-3-furan-2-yl-5-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester
  • MLS000122207
  • SMR000119674
  • ASN 06209591

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0057 0.0059
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0692 0.2241
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0168 0.0168
Brugia malayi hypothetical protein 0.0123 0.0677 0.2371
Echinococcus multilocularis lamin 0.0027 0.0082 0.0082
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0019 0.0068
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0255 0.0894
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0168 0.0173
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1132 0.1132
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0149 0.6537
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.2854 0.2935
Schistosoma mansoni hypothetical protein 0.01 0.0534 0.0549
Brugia malayi hypothetical protein 0.0159 0.0897 0.3141
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0168 0.0173
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0168 0.0173
Brugia malayi nuclear receptor RXR 0.0019 0.0033 0.0116
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0135 0.3343
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0228 1
Schistosoma mansoni nuclear receptor 0.0019 0.0033 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0168 0.0589
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0033 0.0033
Trypanosoma brucei unspecified product 0.0016 0.0012 0.0546
Onchocerca volvulus Huntingtin homolog 0.0123 0.0677 0.7549
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0014 0.0044
Brugia malayi Coelomocyte uptake defective protein 5 0.0076 0.0385 0.1348
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.021 0.0679
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0048 0.021 0.0735
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0614 0.1988
Onchocerca volvulus 0.0041 0.0168 0.1874
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0534 0.0549
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0228 0.0737
Plasmodium falciparum thioredoxin reductase 0.0017 0.0019 0.0531
Brugia malayi latrophilin 2 splice variant baaae 0.0217 0.1256 0.4399
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.0534 0.0549
Brugia malayi AMP-binding enzyme family protein 0.0048 0.021 0.0735
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.0323
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0168 0.0589
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.021 0.0679
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0048 0.0049
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0228 0.0234
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0149 0.6537
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.0735
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0019 0.0531
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0183 0.5033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.021 0.3529
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0228 0.0234
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0168 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0048 0.0167
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0057 0.0963
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0057 0.0059
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0614 0.1988
Mycobacterium ulcerans L-lysine aminotransferase 0.0073 0.0364 0.118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0255 0.0262
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0073 0.0364 0.118
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0057 0.0185
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0057 0.0057
Brugia malayi glutaminase DH11.1 0.0287 0.169 0.592
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0168 0.0173
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0057 0.0185
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.002
Echinococcus multilocularis lamin dm0 0.0027 0.0082 0.0082
Plasmodium falciparum thioredoxin reductase 0.005 0.022 0.6044
Brugia malayi MAP kinase sur-1 0.0051 0.0228 0.0797
Echinococcus multilocularis expressed protein 0.0039 0.0155 0.0155
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0073 0.0364 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0057 0.0185
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0014 0.0597
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0183 0.0642
Brugia malayi nuclear receptor NHR-88 0.0019 0.0033 0.0116
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0033 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.021 0.9214
Schistosoma mansoni hypothetical protein 0.1584 0.9727 1
Brugia malayi hypothetical protein 0.0022 0.0048 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0168 0.0589
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0228 0.0737
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0168 0.0173
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0014 0.0597
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0692 0.2241
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0168 0.0168
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0048 0.0048
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0033 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0019
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0012 0.0516
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0073 0.0364 0.1276
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0168 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0255 0.0262
Plasmodium falciparum glutathione reductase 0.0017 0.0019 0.0531
Echinococcus granulosus intermediate filament protein 0.0027 0.0082 0.0084
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0155 0.0541
Brugia malayi Smad1 0.0017 0.0019 0.0068
Schistosoma mansoni Smad4 0.0017 0.0019 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0168 0.0168
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0168 0.0168
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0183 0.0594
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0082 0.0286
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1132 0.3966
Schistosoma mansoni smad 0.0017 0.0019 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0019 0.085
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0012 0.0323
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0033 0.0371
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0168 0.0173
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0057 0.0185
Plasmodium falciparum glutathione reductase 0.005 0.022 0.6044
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0183 0.0594
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0033 0.0034
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.002
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1132 0.1164
Brugia malayi nuclear hormone receptor 0.0019 0.0033 0.0116
Echinococcus multilocularis protein dispatched 1 0.0048 0.0211 0.0211
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0174 0.0609
Echinococcus granulosus mucolipin 3 0.0076 0.0385 0.0395
Onchocerca volvulus 0.0048 0.021 0.2339
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0019 0.085
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.021 0.0679
Trypanosoma brucei trypanothione reductase 0.005 0.022 0.9674
Brugia malayi nuclear hormone receptor 0.0041 0.0168 0.0589
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0546
Loa Loa (eye worm) DR-78 0.0019 0.0033 0.0116
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0033 0.0371
Entamoeba histolytica hypothetical protein 0.011 0.0594 1
Brugia malayi MH1 domain containing protein 0.0017 0.0019 0.0068
Schistosoma mansoni DNA polymerase eta 0.0023 0.0057 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Onchocerca volvulus 0.0019 0.0033 0.0371
Onchocerca volvulus 0.0027 0.0082 0.0911
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0135 0.0436
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0228 1
Brugia malayi hypothetical protein 0.011 0.0594 0.2082
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0183 0.3086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.2854 0.2854
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0183 0.0642
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0033 0.0033
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0183 0.0189
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0033 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0019 0.085
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0594 0.0611
Loa Loa (eye worm) glutaminase 2 0.0287 0.169 0.592
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0169
Brugia malayi MH2 domain containing protein 0.0252 0.1477 0.5176
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0183 0.0594
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0057 0.2515
Echinococcus granulosus dna polymerase eta 0.0023 0.0057 0.0059
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0513 0.3089 1
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0183 0.8056
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Onchocerca volvulus 0.0097 0.0513 0.572
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0168 0.0589
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0073 0.0364 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0014 0.0044
Schistosoma mansoni zinc finger protein 0.0019 0.0033 0.0034
Schistosoma mansoni survival motor neuron protein 0.0097 0.0513 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0155 0.05
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0019 0.085
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Brugia malayi nuclear receptor NHR-67 0.0019 0.0033 0.0116
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0135 0.0436
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0057 0.0185
Giardia lamblia DINP protein human, muc B family 0.0023 0.0057 0.182
Schistosoma mansoni alpha-glucosidase 0.0169 0.0962 0.0989
Entamoeba histolytica hypothetical protein 0.011 0.0594 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0317 0.1877 0.6577
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0168 0.0589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.021 0.0679
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0048
Plasmodium vivax ornithine aminotransferase, putative 0.0073 0.0364 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0014 0.0048
Onchocerca volvulus 0.0114 0.0618 0.6892
Echinococcus granulosus GPCR family 2 0.01 0.0534 0.0549
Mycobacterium tuberculosis Probable aminotransferase 0.0513 0.3089 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Trichomonas vaginalis rotamase, putative 0.0038 0.0149 0.0482
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0033 0.0034
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0174 0.0174
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0397
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.021 0.3529
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0614 0.1988
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0168 0.0589
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0149 0.6537
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0174 0.0563
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.01 0.0534 0.1872
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0019 0.0063
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0228 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0183 0.8056
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.021 0.0679
Echinococcus granulosus Aminotransferase class III 0.0073 0.0364 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0546
Brugia malayi AMP-binding enzyme family protein 0.0048 0.021 0.0735
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.021 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0168 0.0589
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0033 0.0033
Echinococcus multilocularis microtubule associated protein 2 0.0759 0.4613 0.4613
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Echinococcus granulosus dna polymerase kappa 0.0023 0.0057 0.0059
Schistosoma mansoni hypothetical protein 0.01 0.0534 0.0549
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.1477 0.5176
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0692 0.2241
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0275
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0019 0.0531
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0201
Onchocerca volvulus 0.0027 0.0082 0.0911
Onchocerca volvulus Huntingtin homolog 0.0123 0.0677 0.7549
Echinococcus multilocularis smad 0.0017 0.0019 0.0019
Mycobacterium tuberculosis Probable reductase 0.0113 0.0614 0.1988
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0286
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0019 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0168 0.0589
Mycobacterium ulcerans glutaminase 0.0287 0.169 0.5471
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0534 0.1872
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0228 0.6247
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0019 0.0063
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0003 0.0012
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0019 0.085
Mycobacterium ulcerans hypothetical protein 0.0513 0.3089 1
Brugia malayi glutathione reductase 0.005 0.022 0.0771
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0073 0.0364 0.118
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0019 0.0531
Brugia malayi Calcitonin receptor-like protein seb-1 0.0317 0.1877 0.6577
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0019 0.085
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0135 0.3696
Schistosoma mansoni lamin 0.0027 0.0082 0.0084
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0033 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0033 0.0034
Schistosoma mansoni alpha-glucosidase 0.0169 0.0962 0.0989
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0019 0.0063
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0019 0.0531
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0228 1
Brugia malayi intermediate filament protein 0.0027 0.0082 0.0286
Loa Loa (eye worm) hypothetical protein 0.0217 0.1256 0.4399
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Schistosoma mansoni microtubule-associated protein tau 0.0759 0.4613 0.4743
Schistosoma mansoni coup transcription factor 0.0041 0.0168 0.0173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0012 0.0012
Loa Loa (eye worm) glutaminase 0.0287 0.169 0.592
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0513 0.3089 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0534 0.1872
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0019 0.002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0516
Schistosoma mansoni hypothetical protein 0.01 0.0534 0.0549
Echinococcus multilocularis musashi 0.0027 0.0082 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0082 0.0286
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.022 0.0713
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0168 0.0589
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Echinococcus granulosus Smad4 0.0017 0.0019 0.002
Schistosoma mansoni rotamase 0.0039 0.0155 0.0159
Plasmodium vivax glutathione reductase, putative 0.005 0.022 0.6044
Echinococcus multilocularis Aminotransferase class III 0.0073 0.0364 0.0364
Brugia malayi hypothetical protein 0.0475 0.2854 1
Schistosoma mansoni mucolipin 0.007 0.0345 0.0355
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.021 0.0679
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0048 0.0167
Schistosoma mansoni nuclear receptor 0.0019 0.0033 0.0034
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0149 0.4084
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0228 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0033 0.0116
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0014 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) Smad1 0.0017 0.0019 0.0068
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0033 0.0116
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0513 0.3089 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0135 0.3696
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0019 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0168 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0168 0.0589
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0033 0.0116
Brugia malayi MH2 domain containing protein 0.0017 0.0019 0.0068
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0183 0.3086
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.021 0.0679
Loa Loa (eye worm) glutathione reductase 0.005 0.022 0.0771
Brugia malayi Latrophilin receptor protein 2 0.01 0.0534 0.1872
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0003 0.0012
Schistosoma mansoni hypothetical protein 0.0097 0.0513 0.0527
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0073 0.0364 0.118
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0048 0.0167
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0521 0.0536
Loa Loa (eye worm) mucolipin 1 0.0076 0.0385 0.1348
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0033 0.0116
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0033 0.0116
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0228 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0255 0.0255
Echinococcus multilocularis expressed conserved protein 0.0092 0.0484 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0168 0.0589
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0168 0.0173
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0168 0.0168
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0168 0.0173
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0168 0.0173
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0019 0.002
Brugia malayi hypothetical protein 0.0022 0.0048 0.0167
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0073 0.0364 0.118
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0228 0.0737
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0168 0.0173
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0472
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0168 0.0589
Loa Loa (eye worm) hypothetical protein 0.0159 0.0897 0.3141
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0168 0.0589
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0019 0.085
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0014 0.0229
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0228 0.0737
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0255 0.0262
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0168 0.1874
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0168 0.0589
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0073 0.0364 0.118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0183 0.0594
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0614 0.1988
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0033 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0019 0.0531
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0594 0.0594
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0317 0.1877 0.6577
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0033 0.0034
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.021 0.0679
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.0323
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0255 0.0262
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0168 0.0589
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0782 0.0782
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0019 0.0531
Treponema pallidum NADH oxidase 0.0017 0.0019 0.5
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0012 0.0012
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0019 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0168 0.0173
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1132 0.1132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0168 0.0173
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0594 0.0611
Echinococcus granulosus expressed protein 0.0039 0.0155 0.0159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0534 0.0534
Echinococcus multilocularis mucolipin 3 0.0076 0.0385 0.0385
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.0534 0.0534
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0033 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0057 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0168 0.0589
Brugia malayi isocitrate dehydrogenase 0.0016 0.0012 0.0041
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0033 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0168 0.0173
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0513 0.3089 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.021 0.9214
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0019 0.0063
Echinococcus granulosus ornithine aminotransferase 0.0073 0.0364 0.0375
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0228 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0073 0.0364 0.0375
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0228 1
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.022 0.9674
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0057 0.2515
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0168 0.0589
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0169
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0012 0.0041
Brugia malayi hypothetical protein 0.0019 0.0033 0.0116
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.022 0.0226
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0019 0.0019
Brugia malayi ecdysteroid receptor 0.0041 0.0168 0.0589
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0168 0.0589
Schistosoma mansoni mucolipin 0.0076 0.0385 0.0395
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0168 0.1874
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0782 0.0804
Brugia malayi Thioredoxin reductase 0.005 0.022 0.0771
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0228 0.0228
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0168 0.0173
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0014 0.0597
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.021 0.0679
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0516
Onchocerca volvulus 0.0159 0.0897 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0255 0.0894
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0019 0.0068
Entamoeba histolytica hypothetical protein 0.011 0.0594 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0012 0.0516
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0012 0.0012
Echinococcus multilocularis dna polymerase eta 0.0023 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0048 0.0049
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0174 0.0179
Trypanosoma brucei protein kinase, putative 0.0051 0.0228 1
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0073 0.0364 0.118
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0174 0.0179
Loa Loa (eye worm) hypothetical protein 0.0123 0.0677 0.2371
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.022 0.022
Echinococcus granulosus geminin 0.1584 0.9727 1
Schistosoma mansoni hypothetical protein 0.1584 0.9727 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0057 0.2515
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0012 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0255 0.0262
Loa Loa (eye worm) hypothetical protein 0.0317 0.1877 0.6577
Trichomonas vaginalis rotamase, putative 0.0039 0.0155 0.05
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0183 0.0183
Brugia malayi MH2 domain containing protein 0.0017 0.0019 0.0068
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0033 0.0116
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0033 0.0116
Leishmania major DNA polymerase eta, putative 0.0023 0.0057 0.2515
Schistosoma mansoni intermediate filament proteins 0.0027 0.0082 0.0084
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0057 0.2515
Schistosoma mansoni hypothetical protein 0.0041 0.0164 0.0169
Mycobacterium ulcerans acetylornithine aminotransferase 0.0073 0.0364 0.118
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0048 0.0049
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0513 0.1797
Brugia malayi nuclear receptor RXR 0.0022 0.0048 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0168 0.0589
Leishmania major trypanothione reductase 0.005 0.022 0.9674
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.0735
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0057 0.2515
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0073 0.0364 0.118
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0019 0.002
Echinococcus multilocularis ornithine aminotransferase 0.0073 0.0364 0.0364
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0033 0.0034
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0073 0.0364 0.118
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0228 0.0797
Echinococcus multilocularis ornithine aminotransferase 0.0073 0.0364 0.0364
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0168 0.0173
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.0735
Schistosoma mansoni alpha glucosidase 0.0044 0.0183 0.0189
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0057 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0073 0.0364 1
Echinococcus granulosus lamin 0.0027 0.0082 0.0084
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0073 0.0364 0.118
Echinococcus multilocularis Smad4 0.0017 0.0019 0.0019
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0019 0.085
Loa Loa (eye worm) hypothetical protein 0.0475 0.2854 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0057 0.0201
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0168 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Echinococcus granulosus microtubule associated protein 2 0.0759 0.4613 0.4743
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0168 0.1874
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0014 0.0597
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0521 0.8769
Loa Loa (eye worm) hypothetical protein 0.0052 0.0233 0.0815
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0168 0.0173
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0014 0.0044
Loa Loa (eye worm) thioredoxin reductase 0.005 0.022 0.0771
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0082 0.0286
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.021 0.3529
Echinococcus multilocularis protein patched 0.0042 0.0174 0.0174
Brugia malayi CHE-14 protein 0.0042 0.0174 0.0609
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0057 0.0201
Entamoeba histolytica hypothetical protein 0.011 0.0594 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1132 0.3966
Mycobacterium ulcerans hypothetical protein 0.0048 0.021 0.0679
Plasmodium vivax thioredoxin reductase, putative 0.005 0.022 0.6044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Schistosoma mansoni patched 1 0.0042 0.0174 0.0179
Schistosoma mansoni lamin 0.0027 0.0082 0.0084
Trichomonas vaginalis glutaminase, putative 0.0287 0.169 0.5471
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0546
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0057 0.0057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0397
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0692 0.2241
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0614 0.1988
Trypanosoma brucei unspecified product 0.0023 0.0057 0.2515
Echinococcus multilocularis GPCR, family 2 0.01 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0123 0.0677 0.2371
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0255 0.0255
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0019 0.0063
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0168 0.0168
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0019 0.085
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Brugia malayi MH1 domain containing protein 0.0017 0.0019 0.0068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.021 0.0679
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0073 0.0364 0.118
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0033 0.0034
Brugia malayi ecdysone receptor 0.0019 0.0033 0.0116
Schistosoma mansoni glutaminase 0.0287 0.169 0.1737
Onchocerca volvulus 0.0019 0.0033 0.0371
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0589
Brugia malayi steroid hormone receptor 0.0041 0.0168 0.0589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Echinococcus granulosus smad 0.0017 0.0019 0.002
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0012 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0516
Echinococcus granulosus expressed conserved protein 0.0092 0.0484 0.0498
Trypanosoma brucei unspecified product 0.0016 0.0012 0.0546
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0168 0.0173
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.021 0.9214
Loa Loa (eye worm) hypothetical protein 0.0042 0.0174 0.0609
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.1477 0.5176
Brugia malayi hypothetical protein 0.0019 0.0033 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0168 0.0589
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0155 0.0541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0183 0.8056
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0168 0.0173
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0019 0.0019
Echinococcus granulosus lamin dm0 0.0027 0.0082 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0167
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0019 0.0063
Brugia malayi nuclear receptor NHR-88 0.0041 0.0168 0.0589
Brugia malayi tailless protein 0.0019 0.0033 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0168 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0397
Trypanosoma brucei glucosidase, putative 0.0044 0.0183 0.8056
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.2515
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0168 0.0589
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0183 0.0594
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0019 0.085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0168 0.0589
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0614 0.1988
Schistosoma mansoni hypothetical protein 0.01 0.0534 0.0549
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0149 0.2504
Schistosoma mansoni hypothetical protein 0.0217 0.1256 0.1291
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0033 0.0116
Toxoplasma gondii thioredoxin reductase 0.005 0.022 0.6044
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.053 0.0545
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0098 0.0521 0.1826
Echinococcus multilocularis geminin 0.1584 0.9727 0.9727
Brugia malayi conserved hypotetical protein 0.0019 0.0033 0.0116
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0228 0.0234
Plasmodium falciparum ornithine aminotransferase 0.0073 0.0364 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0168 0.0589
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0057 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0168 0.0589
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0012 0.0041
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0149 0.6537
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0073 0.0364 0.118
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0521 0.1826
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0116
Schistosoma mansoni hypothetical protein 0.011 0.0594 0.0611

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.